F30-02:Under this test conditions OCBC is inherently biodegradable.(99 % after 9 days with adaptation period of 6 days)
under test conditions no biodegradation observed
under test conditions, not readily biodegradable
Silicic acid, calcium salt (IUC4 DSN 82)
RD50 (50 % decrease of respiration rate)
Substance classification:|Sodium compounds|Carboxylic acid salts
triisooctyl 2,2',2''-[(methylstannylidyne)tris(thio)]triacetate (IUC4 DSN 34)
1,1,1,3,3,3-hexamethyldisilazane (IUC4 DSN 141)
Substance classification:|Alcohols|Sulphides, organic (thioethers)
slowly biodegraded under anaerobic conditions
Clariant Produkte (Deutschland) GmbH / Sulzbach am Taunus / Germany
50-00-0_Formaldehyde_TRA0001_CLN test substance_TST_DE00_REACH P3
bis(4-chlorophenyl) sulphone (IUC4 DSN 262)
1-Chloro-1,2,2,2-tetrafluoroethane (IUC4 DSN 92)
4-hydroxy-4-methylpentan-2-one (IUC4 DSN 32)
3,5,5-trimethylcyclohex-2-enone (IUC4 DSN 40)
N-(3-(trimethoxysilyl)propyl)ethylenediamine (IUC4 DSN 64)
2-ethylhexyl 4,4-dibutyl-10-ethyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate (IUC4 DSN 24)
not readily biodegradable according to guideline, but inherently biodegradable in the test
2,4-DNT completely degraded, intermittantly observed intermediates not detectable at the end of treatment
2,3-DNT, 2,4-DNT and 2,6-DNT mineralized by indigenous soil bacteria, 2,4-DNT and 2,6-DNT by isolated bacterial strains
2,4-DNT and 2,6-DNT are both primarily degradable in aquatic microcosms
biodegradable by three Burkholderia strains
2,4-DNT and 2,6-DNT were mineralized simultaneously
in methanogenic soil environment 2,4-DNT is degraded completely
Conditions of 2,4-DNT and 2,6-DNT mineralization elucidated
degradation of 2,4-DNT and 2,6-DNT to aromatic amines
Biotransformation products of 2,4-DNT and 2,6-DNT found
100 % of nitro compounds and 97 % of intermittantly formed amino compounds degraded
Removal of high levels of explosives by planted, non-planted, and non-planted UV-shielded wetlands
2,4-DNT and 2,6-DNT mineralized by soil bacteria and several isolated bacterial strains
2,4-DNT and 2 amino metabolites degraded, ammonia released
2,4-DNT and 2,6-DNT were mineralized (after adaption: half-life 2-4 d)
Dioxygenase from E. coli oxidizes 2,4-DNT and 2,6-DNT to catechols
Nitrite is released from 2,4-DNT under aerobic and anaerobic conditions
2,4-DNT and 2,6-DNT were mineralized by several bacterial strains
2,4-DNT and 2,6-DNT were mineralized (28 and 8 %, repectively) and biotransformed
2,4-DNT was cometabolized but not mineralized
biodegradation and photodegradation under field conditions observed
Burkholderia cepacia wildtype and genetically modified strain grow on 2,4-DNT as sole source of carbon (mineralization not qua
During degradation of 2,4-DNT nitroso and amino intermediates are formed which are completely degraded within 2 weeks of incub
Reductive biotransformation of both isomers within a few hours
2,4-DNT was degraded under cometabolic conditions
2-ethylhexyl mercaptoacetate (IUC4 DSN 11)
disodium 4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino]stilbene-2,2'-disulphonate (IUC4 DSN 135)
not expected to be readily biodegradable
Silicic acid, potassium salt (IUC4 DSN 146)
2-piperazin-1-ylethylamine (IUC4 DSN 184)
under test conditions (reduced contact time) poorly eliminated from water
under test conditions partly / moderately eliminated from water, mainly by biodegradation
under test conditions (reduced contact time) partly / moderately eliminated from water, mainly by biodegradation
2-(2-aminoethylamino)ethanol (IUC4 DSN 4467)
biodegradable (lag periods and complete degradation time varies)
diisooctyl 2,2'-[(dimethylstannylene)bis(thio)]diacetate (IUC4 DSN 31)
2-(1-phenylethyl)-p-xylene (IUC4 DSN 60)
2-(2-ethoxyethoxy)ethyl acetate (IUC4 DSN 66)
readily biodegradable (but not according to OECD criteria)
Amines, C12-14-alkyldimethyl (IUC4 DSN 67)
N,N''-(isobutylidene)diurea (IUC4 DSN 150)
benzene-1,2,4-tricarboxylic acid (IUC4 DSN 38)
2-(2-hexyloxyethoxy)ethanol (IUC4 DSN 68)
2,3-epoxypropyl methacrylate (IUC4 DSN 10)
N-1,3-dimethylbutyl-N'-phenyl-p-phenylenediamine (IUC4 DSN 80)
Based on BOD, ca. 2 % of 6PPD was biodegraded; based on HPLC, ca. 92 % fo 6PPD was degraded
Substance classification:|Carboxylic acid esters
(E)-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-one (IUC4 DSN 122)
diammonium peroxodisulphate (IUC4 DSN 40)
2,6-di-tert-butyl-p-cresol (IUC4 DSN 74)
3-aminomethyl-3,5,5-trimethylcyclohexylamine (IUC4 DSN 27)
under test conditions no significant ring cleavage detected
LOAEL(general tox., adult and offspring)
biodegradable with adapted microorganisms
alpha,alpha,alpha-trichlorotoluene (IUC4 DSN 21)
easily eliminated from water (mainly by biodegradation)
tris(2-hydroxyethyl)-1,3,5-triazinetrione (IUC4 DSN 36)
benzene-1,2,4-tricarboxylic acid 1,2-anhydride (IUC4 DSN 39)
[3-(2,3-epoxypropoxy)propyl]trimethoxysilane (IUC4 DSN 59)
potassium sodium 4,4'-bis[6-anilino-4-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl]amino]s tilbene-2,2'-disulphonate (IUC4 DSN 153)
easily eliminable from water, inherently biodegradable
octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate (IUC4 DSN 141)
dipotassium peroxodisulphate (IUC4 DSN 42)
poorly biodegradable, under test conditions
anaerobic biodegradation test. Degradation rate based on disappearance of test substance form the test solution.
biodegradation influenced by several soil-dependent factors
Calculated half-life in aquatic microcosm: 12 days (non-sterile)
6-phenyl-1,3,5-triazine-2,4-diyldiamine (IUC4 DSN 31)
N-tert-butylbenzothiazole-2-sulphenamide (IUC4 DSN 51)
3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate (IUC4 DSN 1194)
MWCNT with or without structural defects did not induce mesothelioma in this bioassay
Multi-Walled Carbon Nanotubes (MWCNT), synthetic graphite in tubular shape
4-aminotoluene-3-sulphonic acid (IUC4 DSN 55)
Substance classification:|Carboxylic acids
Acute bacterial toxicity (probably EC50)
2-Furanmethanol, tetrahydro- (IUC4 DSN 19)
under test conditions not readily biodegradable
3-methoxy-3-methylbutan-1-ol (IUC4 DSN 71)
1,2-dichloro-4-nitrobenzene (IUC4 DSN 22)
under denitrifying and methanogenic conditions 1,2-dichloro-4-nitrobenzene was removed from the medium
under denitrifying and methanogenic conditions 1,2-dichloro-4-nitrobenzene was rapidly removed from the medium (50 % / > 99 %)
about 31 % of initial substance was transformed to 3,4-dichloroaniline, another 36 % was further degraded
Substance classification:|Calcium compounds|Carboxylic acid salts
under test conditions no degradation observed
under test conditions elimination (primarily biodegradation) after lag phase, but not inherently biodegradable according to cr
Mean BOD*100/COD after 28 days: ca. 75%; mean DOC elimination after 28 days: ca. 67%
not readily biodegradable, under test conditions
methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate (IUC4 DSN 51)
5-ethylidene-8,9,10-trinorborn-2-ene (IUC4 DSN 37)
inherently biodegradable, missed ready biodegradability because of 10-day-window criterium
3,7,11,15-tetramethylhexadec-1-en-3-ol (IUC4 DSN 52)
4,5-dihydroxy-1,3-bis(hydroxymethyl)imidazolidin-2-one (IUC4 DSN 68)
3,4-dihydro-2-methoxy-2H-pyran (IUC4 DSN 73)
Knie, J. et al., Deutsche Gewaesserkundl. Mitt. 27 (3),|77-79 (1983)
Method: other: according to Tuempling v.W. (Fortschritte der Wasserchemie. 14 S: 205-213 (1972) using a Warburg apparatus
Toxicity to aquatic algae and cyanobacteria, IUC4#2/Ch.4.3
Elias, Z et al. (1996) Occupational Hygiene 2: 187-212.
Genetic toxicity in vitro, IUC4#11/Ch.5.5
Merkle J. And Zeller H. (1980). Arzneim. Forsch./Drug|Research, 30, 9:1557-1562.
Developmental toxicity / teratogenicity, IUC4#6/Ch.5.8.2
comparison of cell density at the end of test
in vivo cytogenicity / chromosome aberration study
CERI. (2004) Study on biodegradability of p-toluic acid. Unpublished data.
OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
Biodegradation in water: screening tests, IUC4#1/Ch.3.5
Östling CE and Lindgren SE (1993). Inhibition of|enterobacteria and Listeria growth by lactic, acetic and|formic acids. Journal of Applied Bacteriology 75, 18-24.
Toxicity to microorganisms, IUC4#24/Ch.4.4
Method: other: according Clive et al.: 1979
Genetic toxicity in vitro, IUC4#4/Ch.5.5
FMC Corporation, Acute inhalation toxicity study with|ammonium persulfate in the rat, Study no. I87-0969, 1989.
EPA OPP 81-3 (Acute inhalation toxicity)
Acute toxicity: inhalation, IUC4#1/Ch.5.1.2
WIL Research Laboratories, LLC (2006) A|REPRODUCTION/DEVELOPMENTAL TOXICITY SCREENING STUDY OF|METHYL ETHYL KETONE PEROXIDE IN RATS STUDY NUMBER|WIL-497004. 14 March 2006.
Repeated dose toxicity: oral, IUC4#1/Ch.5.4
Krivanek, N.D. et al.: "Skin initiation/promotion study with|formaldehyde in CD1 mice"; in: Clary, J.J. et al. (eds.):|"Formaldehyde, toxicology epidemiology and mechanisms",|Marcel Dekker, Inc.; New York, 159-172, (1983), No information
Repeated dose toxicity: dermal, IUC4#105/Ch.5.4
BASF AG, Dep. Ecology, unpublished data, Datenerhebung für|oekotoxikologische Untersuchungen vom 18.1.1988
Method: other: DIN 38412 Part 27 (draft)
Toxicity to microorganisms, IUC4#1/Ch.4.4
Leach CL, Abdo KM, Chou BJ, Roycroft JH, and Mellcik PW|(1989). 13-week inhalation toxicity study of formic acid in|rats and mice. The Toxicologist, 144. Society of Toxicology,|abstract of the 28th meeting, abstract No. 575.
OECD Guideline 413 (Subchronic Inhalation Toxicity: 90-Day)
Repeated dose toxicity: inhalation, IUC4#5/Ch.5.4
E.I. Du Pont de Nemours & Co. 1984. EPA/OTS, Doc #878221476; zitiert in: TOXALL (1991)
Acute toxicity: inhalation, IUC4#2/Ch.5.1.2
Thiem K-W, Sewekow B, Kiel W, Handschuh V (1979) Ullmanns|Encyklopaedie der technischen Chemie, 4th Edition (17)|Verlag Chemie, Weinheim, New York, 383, 393 - 397
Solubility in organic solvents / fat solubility, IUC4#7/Ch.2.6.1
Sabljic A, Guesten H, Verhaar H, Hermens J (1995) QSAR|Modelling of Soil Sorption. Improvements and Systematics of|log Koc vs. log Kow Correlations. Chemosphere 31 (11/12):|4489 - 4514
Adsorption / desorption, IUC4#10/Ch.3.3.2
Yoshida, S., S. Nawai, and K. Hiraga. Cytogenetic Studies of Acetaminophen and Its Related Compounds, Ann. Rep. Tokyo Metr. Res. Lab. Pub. Health 31(2), 102-108, 1980
LaLonde RT, Ramdayal F (1997) Mucochloric acid action on|phi-x174 DNA: a comparison to other chlorine-substituted|2(5H)-furanones. Chem Res Toxicol 10: 205-210
Method: other: chemical reactivity of MCA with PHIX174 DNA
Genetic toxicity in vitro, IUC4#16/Ch.5.5
Battersby, N.S. & Wilson, V., Appl. Environ. Microbiol. 55,|433-439 (1989)
Biodegradation in water: screening tests, IUC4#2/Ch.3.5
ATSDR (Agency for Toxic Substances and Disease Registry). 2005. Toxicological Profile for Tin and Tin Compounds. Department of Health and Human Services. Public Health Service. Available at: http://www.atsdr.cdc.gov/toxprofiles/tp55.html.
Phototransformation in air, IUC4#2/Ch.3.1.1
Anard D, Kirsch-Volders M, Elhajouji A, Belpaeme K and Lison|D (1997). In vitro genotoxic effects of hard metal particles|assessed by alkaline single cell gel and elution assays.|Carcinogenesis 18, 177-184.
Genetic toxicity in vitro, IUC4#3/Ch.5.5
Avery, S.V., M.E. Miller, G.M. Gadd, G.A. Codd, and J.J. Cooney. 1991. Toxicity of organotins towards cyanobacterial photosynthesis and nitrogen fixation. FEMS Microbiol. Lett. 84:205-210.
Toxicity to microorganisms, IUC4#4/Ch.4.4
Fischer L et al., Chemische Konstitution und|pharmakologische Wirkung der Glykole unter Berücksichtigung|von 1,3-butylenglykol Zeitschr. Ges. Experim Mediz 115:|22-39, 1949 (19)
Repeated dose toxicity: oral, IUC4#43/Ch.5.4
Plevan, R.E. (1991) Rationale Document for Trimethoxysilane.|Union Carbide. Cited in AIHAJ (1997) Workplace Environmental|Exposure Level Guides: Trimethoxysilane (1997)
Acute toxicity: inhalation, IUC4#6/Ch.5.1.2
Hatch, G. Anderson T., Elmore, E. and Nesnow, S.: Abstract|Cd-26 of the Fourteenth Annual Meeting of the Environmental|Mutagen Society March 3-6, 1983. Environmental Mutagenesis|5:422 (1983).
Method: other: in general conformance with OECD 476
Genetic toxicity in vitro, IUC4#8/Ch.5.5
Norsk Hydro ASA (2002). Revised Chemical Dossier for|Formi(TM) LHS, July 2002.
EPA (2008). AOPWIN v1.92. Estimation Programs Interface for Microsoft Windows (EPI Suite version 3.20, U.S. Environmental Protection Agency, Office of Pollution Prevention and Toxics, Washington, D.C.)
Method: other (calculated): The photodegradation was estimated with EPI Suite version 3.20.
Phototransformation in air, IUC4#1/Ch.3.1.1
Lipnick, R.L. et al., Environmental Toxicology and Chemistry|4, 281-296, (1985)
Short-term toxicity to fish, IUC4#8/Ch.4.1
Hudson RF (1947). The vapour phase hydrolysis of|non-metallic chlorides. International Congress of Pure and|Applied Chemistry (London) 11, 297-305.
Example Company 1 / Example city / Finland
McOmie, W.A. et al. (1949): J. Am. Pharm. Assoc. Sci. Ed.|38, 366 - 369
Chibanguza G (1985). Prufung von Leichte Calc. Soda im|Augenreiztest am Kaninchen. IBR Forschungs GmbH, projekt nr|3-3-395-85.
EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
Daikin Kogyo Co Ltd. Cover letter and short letter report. |1977.
Acute toxicity: inhalation, IUC4#3/Ch.5.1.2
Covance Laboratories (1998). Formi LHS. 13 week oral|(dietary administration) range-finding study in the mouse.|Unpublished final study report No. 1516/31-D6154 dated|October 1999. Sponsored by Hydro Nutrition, Oslo.
Method: other: range finding study, similar to OECD TG 408.
Repeated dose toxicity: oral, IUC4#3/Ch.5.4
OECD Guideline 473 (In vitro Mammalian Chromosome Aberration Test)
Tabak et al. (1964) Microbial Metabolism of Aromatic Compounds. Journal of Bacteriology 87(4):910-919.
Method: other: Determination of degradation from oxygen consumption
Biodegradation in water: screening tests, IUC4#6/Ch.3.5
Flickinger, CW (1976) The benzenediols: catechol, resorcinol and hydroquinone - a review of the industrial toxicology and current industrial exposure limits. American Industrial Hygiene Association Journal, 37:596-606.
Tamada, M. et al.: Bokin Bobei 6, 62-68 (1978), No information
Method: other: in vivo chromosomal aberrations - mammals (germ cells)
Genetic toxicity in vivo, IUC4#66/Ch.5.6
Dow Corning Corporation (1960) Dow Corning Corporation|Internal Report No. 1960-I0065-1129-01
Acute toxicity: inhalation, IUC4#10/Ch.5.1.2
Haskell Labs, Subchronic inhalation toxicity study of|o-chloronitrobenzene in rats, at the request of Dupont Chem|Co., OTS 0546562, 1992
Repeated dose toxicity: inhalation, IUC4#14/Ch.5.4
Li, S. et al. (1993). Chinese J. Pharmacol. Toxicol., 7, p. 73-77
Method: other: according to Maron, D.M. and Ames, B.B.: Mutat. Res., 113, 173-215, (1983)
Genetic toxicity in vitro, IUC4#2/Ch.5.5
BASF AG (2005). Safety data sheet according to 91/155/EEC.|FORMIC ACID 85%, last update 23 Jun 2005.
Angus DS (1984) Mutagenicity of seven polycyclic aromatic|hydrocarbon compounds in Drosophila. Heredith Edin 53:|562-563
Rosenblatt DH, Burrows EP, Mitchell WR, Parmer DL (1991)|Organic explosives and related Compounds. In: Hutzinger O|(ed.) The Handbook of Environmental Chemistry 3G, Springer,|Berlin, Heidelberg, pp. 195-237
Hecht SS, El-Bayoumy K, Rivenson A, Fiala E (1983) Bioassay|for carcinogenicity of ,2-dimethyl-4-nitrosobiphenyl,|o-nitrosotoluene, nitrosobenzene and the corresponing amines|in syrian golden hamsters. Cancer Lett 20: 349-354
Method: other: carcinogenicity see freetext TC
CITI (Chemicals Inspection and Testing Institute) (1992).|Biodegradation and bioaccumulation data of existing|chemicals based on the CSCL Japan, p 5-28. Japan Chemical|Industry Ecology-Toxicology & Information Center
Brusick, D. et al.: Environ. Mutagen. 2, 253 (1980);|abstract Ca-6, No information
Method: other: Sister chromatid exchange assay
Genetic toxicity in vitro, IUC4#153/Ch.5.5
Salmonella typhimurium (TA100, TA1535, TA98, TA1537); Escherichia coli (WP2uvrA)
Hooftman, R.N. and J.M. de Wolf. 2003. 1,3,2-Dioxastannepin-4,7-dione, 2,2-dibutyl- (dibutyltin maleate, CAS# 78-04-6): Semi-static acute toxicity test with the zebra fish Brachydanio rerio. TNO Report No. V4017/03. September 2003.
OECD Guideline 203 (Fish, Acute Toxicity Test)
Short-term toxicity to fish, IUC4#1/Ch.4.1
INSTITUT FRESENIUS (1997) N° 96TE103762.|iso-Octylthioglykolat.wasserloeslichkeit nach 92/69/EWG A.6|(Kolben-Methode)
Dow Corning Corporation (1965) REPORT TO DOW CORNING|CORPORATION TOXICITY STUDIES ON HEXAMETHYLDISILAZANE|((CH3)3SI)2NH (Z-6080); 5/28/65; EPA DOC. NO. 86940001059;|FICHE NO. OTS0556513; SUBMITTED BY INDUSTRY, MODIFIED.|Cited in NISC and BiblioLine (2009) BiblioLine -|www.nisc.com
Skin irritation / corrosion, IUC4#7/Ch.5.2.1
BASF AG, Department of Ecology, unpublished data on the|acute toxicity of Glyezin A to the water-flea Daphnia magna|Straus, Report No.: 1/0106/2/88-0106/88, 06.April 1988
Method: other: directive 79/831/EEC, C.2; 1984
Short-term toxicity to aquatic invertebrates, IUC4#1/Ch.4.2
Maeki-Paakkanen J, Laaksonen M, Munter T, Kronberg L,|Komulainen H (2001) Comparable DNA and Chromosome Damage in|Chinese Hamster Ovary Cells by Chlorohydroxyfuranones.|Environ Mol Mutagen 38: 297-305
Method: other: Method in general accordance with OECD method 473; however testing only without metabolic activation; unclear which level of cytotoxicity is reached in the highest concetration
Genetic toxicity in vitro, IUC4#38/Ch.5.5
KOWWIN Version 1.66. 2000.|(http://www.epa.gov/oppt/exposure/docs/episuitedl.htm)
Lu G, Jiang S, and Zhao Y (2001). Quantitative relationship|study for the structure and biodegradability of substituted|benzenes. http://www.chemistrymag.org/cji/2001/031003pe.htm
Method: other: Determination of biodegradation rate constant
Biodegradation in water: screening tests, IUC4#130/Ch.3.5
Sanyal, R. et al.: Mutagenesis 12 (4), 297-303 (1997);|cited in: RIFM database, location no. 31368
Genetic toxicity in vitro, IUC4#93/Ch.5.5
Tsai Y. L.; Tuovinen O. H.; Toxicity Assessment: An|International Journal, vol. 4, 199 - 207 (1989).
Toxicity to microorganisms, IUC4#2/Ch.4.4
Huls Troisdorf AG (1988) Report on the physical-chemical|characteristics of Isobutyl-triethoxy-silane. Report 3363/88| Degussa-Huls AG-Nr.: 88-0353-DKP October 14, 1988
OECD Guideline 103 (Boiling point/boiling range)
BASF AG, Sicherheitsdatenblatt Fixapret CP konz., 13.01.1999
OECD Guideline 201 (Alga, Growth Inhibition Test)
Toxicity to aquatic algae and cyanobacteria, IUC4#1/Ch.4.3
S. typhimurium TA 98, TA 100, TA 1535, TA 1537
Hazelton Laboratories America, Inc. (1993) Methyl Ethyl|Ketone Peroxide (CAS No. 1338-23-4) in Dimethyl Phthalate|(CAS No. 131-11-3) [45:55], Administered Topically to F344/N|Rats and B6C3F1 Mice. NTP Toxicity Report Series No. 18; NIH|Publication No. 93-3341. Study Date: February 1993.
OECD Guideline 411 (Subchronic Dermal Toxicity: 90-Day Study)
Repeated dose toxicity: dermal, IUC4#6/Ch.5.4
Mc Gregor D.F.,Tier II Mutagenic screening of 13 NIOSH|priority compounds:DMAC Rep N° 33 1981 PB83-13390-0
Method: other: Sex Linked Recessive Lethal Test
Bayer AG data, Report No. 14478, March 26 (1986)
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Skin irritation / corrosion, IUC4#10/Ch.5.2.1
Ministry of Health and Welfare (1999) Combined repeat dose|and reproductive/developmental toxicity screening test of|1-chloro-2 (chloromethyl)benzene in rats. Japan Toxicity|Testing Reports of Environmental Chemicals, 7, 492-502.
Method: T40-05:OECD Guideline 422, "Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test"
Toxicity to reproduction, IUC4#1/Ch.5.8.1
KEMI Report No. 11/94. 1994. Mono- and Di-Substituted Organotins Used as Plastic Additives. Volume 1. L. Freij (ed.). Environmental Hazard Assessment. The Swedish National Chemicals Inspectorate. p. 13.
Smyth, H.F., jr. & Carpenter, C.P. (1944) The place of the|range finding test in the industrial toxicology laboratory.|J. Ind. Hyg. Tox. 26, 269-273
Bayer AG (1994). Bestimmung von physikalisch-chemischen Stoffdaten - Dampfdruck. Report No. 94/121 B (unpublished).
Method: other (measured): Comparable to OECD Guideline 104 (1981) - vapor pressure balance
Fleming, C.J. and Forsyth, A. (1998), D5 patch test|reactions to menthol and peppermint, Contact Dermatitis 38,|337-365
Hüls AG (1993b). Internal communication concerning ecotoxicity and biodegradation of isophorone diisocyanate, 23.12.1993.
Method: other: OECD Guideline 301 E (1981) and Directive 84/449/EEC, C.3
Biodegradation in water: screening tests, IUC4#9/Ch.3.5
Nikkilae, O.E., Fette, Seifen, Anstrichmittel 57, 494-98|(1955)
Method: other: static, 22 degree C, pH 7
Bowers Jr JS (2002). Ullmann´s Encyclopedia of Industrial|Chemistry (2002 electronic release), Wiley-VCH Verlag GmbH &|Co. KGaA, Weinheim.
Bringmann G and Kuehn R (1978). Grenzwerte der Schadwirkung|wassergefaehrdender Stoffe gegen Blaualgen (Mycrocystis|aeruginosa) und Gruenalgen (Scenedesmus quadricauda) im|Zellvermehrungshemmtest. Vom Wasser 50, 45-60.
Method: other: Inhibition of cell reproduction according to Bringmann
Toxicity to microorganisms, IUC4#80/Ch.4.4
Martin, C.N. et al.: Cancer Res. 38, 2621-2627 (1978), No information
Method: other: Unscheduled DNA synthesis
Genetic toxicity in vitro, IUC4#169/Ch.5.5
Callas, M.M.R. and Duffaut, N. (1960) Sur la Preparation du|Trimethoxysilane. Bull. Soc. Chim. Fr., (1960) 1481.
MHLW, Japan (2006) Ministry of Health, Labour and Welfare: Micronucleus test of p-toluic acid in mice. [Unpublished study report]
OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
Koppers Company (1970) Internal Communication BIO-FAX Industial |Bio-Test laboratories report, internal records dated December 1970.
CITI, Japan: Report No. 80131K, Chemicals Evaluation and|Research Institute, (1998) unpublished data
Appearance/physical state/colour, IUC4#1/Ch.1.1.1
Eastman Kodac Co., Rochester, N.Y. (1984). Toxicity and|health hazard summary, NTIS/OTS Microfiche 0206524, Doc|878214399.
S. typhimurium TA 78, TA 100, TA 1535, TA 1538
Dawson GW, Jennings AL, Drozdowski D & Rider E, J. Hazard|Mater. 1, 303-318 (1977)
Short-term toxicity to fish, IUC4#4/Ch.4.1
CIBA-GEIGY (1974). Internal report FAT 65'019/A: Biologische|Elimination / Fischtoxizitaet / Klärschlammtoxizitaet of|C.I. Fluorescent Brightener 28/113 (17 % Na-salt),|1974-01-17.
Toxicity to microorganisms, IUC4#40/Ch.4.4
Kao,A.S., J. Air Waste Manage. Assoc.44, 683-696, (1994)
Phototransformation in air, IUC4#3/Ch.3.1.1
WHO (1979): Sulfur oxides and suspended particulate matter.|Environmental Health Criteria No. 8. Ed. by World Health|Organization, Geneva
Bayer AG (1970). Internal information card of C.I.|Fluorescent Brightener 28/113 (98 % free acid).
Biodegradation in water: screening tests, IUC4#60/Ch.3.6
Bayer AG (1959). 1,4-Dichlor-but-2-en und 3,4-Dichlor-but-1-en (Ht. Nr. 2104-5). Toxikologisches und gewerbehygienisches Laboratorium, unveroeffentlichter Bericht vom 20. Mai 1959.
Nakanishi, Y. and Schneider, E.L.: Mutat. Res. 60, 329-337|(1979)
Genetic toxicity in vivo, IUC4#18/Ch.5.6
Booth G (1991) Nitro Compounds, Aromatic. In: Ullmann´s|Encyclopedia of Industrial Chemistry (5th ed), Verlag|Chemie, Weinheim, vol 17, pp 411 - 422
Solubility in organic solvents / fat solubility, IUC4#2/Ch.2.6.1
Cronin MTD, Gregory BW, Schultz TW (1998) Quantitative|Structure-Activity Analyses of Nitrobenzene Toxicity to|Tetrahymena pyriformis. Chem Res Toxicol 11: 902 - 908
Izmerov, N.F. et al.: "Toxicometric Parameters of Indus-|trial Toxic Chemicals under Single Exposure", Moscow,|Centre of International Projects, GKNT, p. 92 (1982)
Zwart, A., 1988. acute inhalation study of methyl bromide in|rats. Zeist, The Netherlands, CIVO Institutes, TNO, 17 pp.|CIVO Report No. V88. 127/27.
Dunnick JK, Elwell MR, Bucher JR (1994) Comparative|toxicities of o-, m- and p-nitrotoluene in 13-week feed|studies in F344 rats and B6C3F1 mice. Fundam Appl Toxicol|22: 411-421
Repeated dose toxicity: oral, IUC4#10/Ch.5.4
BiblioLine(c) (1997-2006) NISC International, Inc. All|Rights Reserved.|www.nisc.com
Melting point/freezing point, IUC4#4/Ch.2.1
PPG Industries, Inc. (1999) Material Safety Data Sheet for|Neo-deacanoyl chloride.
BIBRA (1989) Report of a preliminary study to establish|dietary levels of thioglycolic acid 2-ethylhexylester to be|used in the 28-day study. Brief unpublished report.
Repeated dose toxicity: oral, IUC4#4/Ch.5.4
Szybalski W (1958). Special Microbiological Systems. II.|Observations on Chemical Mutagenesis in Microorganisms. Ann.|N.Y. Acad. Sci. 76, 475-489.
Method: other: Paper disk method with streptomycin-dependent E. coli
Melting point/freezing point, IUC4#40/Ch.2.1
Ministry of International Trade and Industry, Japan (1999): "Blue sheet"
OECD Guideline 111 (Hydrolysis as a Function of pH)
Gad, S. C. et al. (1986) Correlation of Ocular and Dermal|Irritancy of Studies, University of Wisconsin-Superior, USA.|Acute Toxicity of Industrial Chemicals, J. Toxicol.-Cut &|Ocular Toxicol., 5, 195-213.
England, D.C. und Cramer, D., Acute Flow-Through Toxicity |Exposure of Tributyl Phosphate to Gammarus pseudolimnaeus.|September 23, 1991, ABC Laboratories No. 39499, Columbia,|Missouri, USA
Short-term toxicity to aquatic invertebrates, IUC4#160/Ch.4.2
Laboratory of Pharmacology and Toxicology KG, Germany, LPT Report No. 9300/382/95 (1999).
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Ministry of Health and Welfare: Japan, Toxicity Testing|Reports of Environmental Chemicals 5, 359-385 (1997)
Mirsalis JC, Tyson CK, Steinmetz KL, Loh EK, Hamilton CM,|Bakke JP and Spalding JW (1989) Measurement of unscheduled|DNA synthesis and S-phase synthesis in rodent hepatocytes|following in vivo treatment: Testing of 24 compounds.|Environ Mol Mutagen, 14, 155-164.
Method: other: equivalent to draft OECD guideline "Unscheduled DNA synthesis test with mammalian liver cells in vivo
Salmonella typhimurium TA 100, TA 1535, TA 1538
Chemicals InspectionI and testing Institute, Japan (1999): report on physical and chemical properties
Saillenfait A. M., Gallissot F., Langonne I., Sabate J. P.,|Morel G. (2001). Developmental toxicity of|N-Methyl-2-Pyrrolidone administered by gavage or inhalation|to rats. Poster abstract, 29th Conference of the European|Teratology Society, 2-5 September 2001, , Balatonfüred,|Hungary
OECD Guideline 414 (Prenatal Developmental Toxicity Study)
Developmental toxicity / teratogenicity, IUC4#23/Ch.5.8.2
Kitano M (1978) Biodegradation and bioaccumulation test on chemical subsances. OECD Tokyo Meeting. Reference Book TSU-NO. 3 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Biodegradation in water: screening tests, IUC4#11/Ch.3.5
Liber HL (1985) Mutation tests with Salmonella using|8-azaguanine resistance as the genetic marker. Prog Mut Res|5: 213-216
Method: other: 8-Azaguanin-Resistenz-Test according Skopek et al., 1978
Genetic toxicity in vitro, IUC4#44/Ch.5.5
Urano, K. und Kato, Z., Journal of Hazardous Materials 13|(2), 135-145 (1986)
Haarmann & Reimer GmbH: Chemical Safety Data Sheet "Menthol|Liqu.", revision 17.4.2002
Lewis JL (ed.). 1993. Hawley's Condensed Chemical Dictionary|12th Edition Van Nostrand Reinhold Company, New York.
BASF AG, Abteilung Toxikologie; unveroeffentlichte|Untersuchung (XIX/401), 23.06.1970
Munch J.C.: IMS Ind. Med. Surg., 41, 31-33, (1972); cited in BG Chemie (ed.): 2-Methylpropanol-1, in: Toxicological Evaluations 1 - Potential Health Hazards of Existing Chemicals, Springer Verlag, Berlin, pp. 43-57, (1990) cited in IUCLID (2000).
Palitti F, Fiore M, DeSalvia R, Tanzarella C, Ricordy R,|Forster R, Mosesso P, Astolfi S, Loprieno N (1985) Tests for|the induction of chromosomal aberrations in Chinese hamster|ovary (CHO) cells in culture. Prog Mut Res 5: 443-450
Genetic toxicity in vitro, IUC4#103/Ch.5.5
Auergesellschaft (1988) Auertechnikum (12. ed.) Berlin
Wong, D.C.L, P.B. Dorn, and J.P. Salanitro. 1998. Aquatic|Toxicity of Four Oxy-Solvents. Equilon Enterprises, LLC|Technical Information Record WTC-3520.
Toxicity to aquatic algae and cyanobacteria, IUC4#10/Ch.4.3
Steinhaeuser, K.G., W. Amann, A. Spaeth, and A. Polenz. 1985. Untersuchungen zur aquatischen toxizitat zinnorganischer verbindungen. Vom Wasser. 65:203-214.
Roberts et al. (1975) J Fish Res Board Can, 32, 2525-28
Short-term toxicity to aquatic invertebrates, IUC4#33/Ch.4.2
King, E. F. and H. A. Painter, INSERM 106, 143-153 (1981)
Toxicity to microorganisms, IUC4#3/Ch.4.4
5-tert-butyl-2,4,6-trinitro-m-xylene (musk xylene)
Bayer AG (2003) Safety Data Sheet Vulkanox 4020 LG|(2003-07-10)
Budavari, S. (1996): The Merck Index, 12th ed., P 8835.|Whitehouse|Station, NJ
BASF AG, Department of Toxicology, unpublished study,|81/233, 22.02.1982
Method: other: Law No. 117, 1973, Order of the Japanese Prime Minister, the Minister of Heath and Welfare and the Minister of Int. Trade and Industry, No.1, Promulgated July 13, 1974
Bioaccumulation: aquatic / sediment, IUC4#4/Ch.3.7
Matsui S, Okawa Y, and Ota R (1988). Experience of 16 years´|operation and maintenance of the Fukashiba industrial|wastewater treatment plant of the Kashima petrochemical|complex - II. Biodegradability of 37 organic substances and|28 process wastewaters. Water Sci. Tech. 20 (10), 201-210.
Method: other: Activated sludge degradability test
Biodegradation in water: screening tests, IUC4#70/Ch.3.5
BASF AG: Abt. Toxikologie, unveroeffentlichte|Untersuchungen, (XVIII/29), 05.04.(1968)
Hoechst AG. 1972. Unveroeffentlichte Untersuchung [unpublished study(]21.02.1972)
Method: other: ETAD Fermentation tube method "Determination of damage to effluent bacteria by the Fermentation Tube Method"
Lendenmann U, Spain JC, and Smets BF (1998). Simultaneous|biodegradation of 2,4-dinitrotoluene and 2,6-dinitrotolune|in an aerobic fluidized-bed biofilm reactor. Environ.Sci.|Technol. 32, 82-87.
Method: other: aerobic degradation in fluidized-bed biofilm reactor
Biodegradation in water: screening tests, IUC4#80/Ch.3.5
BASF AG, Department of Toxicology, unpublished studies|(VII/310), 9 Dec. 1958
Acute toxicity: inhalation, IUC4#39/Ch.5.1.2
Homburger F, Friedell GH, Weisburger EK, Weisburger JH|(1972) Carcinogenicity of simple aromatic amine derivatives|in mice and rats. Toxicol Appl Pharmacol 22: 280-281
McKenna, M.J., Gushow, T. S., Bell, T.J., Blogg, C.D. and|Burek, J.D.: Toxicology Research Laboratory, Health &|Environ. Sciences, The Dow Chemical Company, Midland,|Michigan. (February, 1981b).
Repeated dose toxicity: inhalation, IUC4#9/Ch.5.4
Cascieri et al., Toxicologist 5, 97 (1985)
Method: other: U.S. EPA TSCA Subchronic Oral Toxicity Test Guideline
Repeated dose toxicity: oral, IUC4#20/Ch.5.4
Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA1538
Westendorf, J., H. Marquardt, and H. Marquardt. 1986. DNA Interaction and Mutagenicity of the Plastic Stabilizer Di-n-Octyltin Dichloride. Drug Res. 36:1263-1264.
Genetic toxicity in vitro, IUC4#12/Ch.5.5
Bio-Research Consultants, Inc. (1973): Carcinogenicity of chemicals present in man's environment, Final report, 31, 271-285 (Weisburger, E.K. et al.)
Cell line CCL 61 (Chinese hamster ovary cells)
Chang, J.C.F. et al.: Toxicol. Appl. Pharmacol. 61, 451-459|(1981), No information
Method: other: sensory irritation according to Alarie, Y.; (no further data)
Acute toxicity: inhalation, IUC4#11/Ch.5.1.2
S. typhimurium TA 1535, TA 1537, TA 1538
Vernot et al. (1977) Toxicol Appl Pharmacol, 42, 417-423
Acute toxicity: inhalation, IUC4#18/Ch.5.1.2
American Chemistry Council's Acetic Acid and Salts Panel|(2003) U.S. HIGH PRODUCTION VOLUME (HPV) CHEMICAL CHALLENGE|PROGRAM - ROBUST SUMMARIES for CARBOXYLIC FOOD ACIDS AND|SALTS CATEGORY. April 16, 2003.
Short-term toxicity to aquatic invertebrates, IUC4#3/Ch.4.2
Bringmann G and Kuehn R (1977). Grenzwerte der Schadwirkung|wassergefaehrdender Stoffe gegen Bakterien (Pseudomonas|putida) und Gruenalgen (Scenedesmus quadricauda) im|Zellvermehrungshemmtest. Z. Wasser- Abwasser-Forsch. 10,|87-98.
Method: other: Inhibition of cell reproduction acc. to Bringmann
Toxicity to microorganisms, IUC4#10/Ch.4.4
IUCLID (International Uniform ChemicaL Information Database) data set (Acetanilide; 103-84-4), June, 1998
Bignami M. et al (1980), Chem. Biol. Interactions, 30, 9-23.
Genetic toxicity in vitro, IUC4#17/Ch.5.5
Barnes, J.M. and H.B. Stoner. 1958. British Journal of Industrial Medicine. 15:15-22.
Roberts DW, Goodwin BFJ, Williams DL, Jones K, Johnson AW,|Alderson JCE (1983) Short Paper: Correlations between skin|sensitization potential and chemical reactivity for|p-nitrobenzyl compounds. Fd Chem Toxicol 21: 811-813
Method: other: according to Goodwin et al., Contact Dermatitis 7, 248 (1981)
Knie J, Haelke A, Juhnke I, Schiller W (1983) Ergebnisse der|Untersuchungen von chemischen Stoffen mit vier Biotests.|Deutsche Gewässerkundliche Mitteilungen 27 (3): 77 - 79
Method: other: Test according to Robra (O2-Consumption)
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Thamavit, W. et al. (1989): Cancer Lett. 45, 93 - 101
Method: other: Wide-Spectrum Initiation/Promotion Assay
Degussa AG (2003), unpublished Report. Combined Repeated|Dose Toxicity study with Reproduction/Developmental|Screening Test by Gavage with Dimethyl malonate in Wistar|Rats. Degussa AG REG. No. 2003-0146-DGT.
OECD Combined Repeated Dose and Reproductive / Developmental Toxicity Screening Test (Precursor Protocol of GL 422)
Rohm & Haas Co., TSCAT, OTS0570648, Doc. I.D. 88-920008034,|Bio/dynamics Inc., Project No. 79-2445, 07. April 1981
Repeated dose toxicity: inhalation, IUC4#11/Ch.5.4
Bjoerndal H, Duering L and Solyom P (1984). Miljoeeffekter|av tillsatskemikalier anvaenda vid papperstillverkning.|Swedish Environmental Research Institute, SSVL-85, Rapport|no. 16, IVL-publ. B 739, Stockholm 1984, 124 p.
Dow Corning Corporation Internal Report Number|1958-I0065-1167-01
Skin irritation / corrosion, IUC4#5/Ch.5.2.1
Richterich K and Muehlberg B (2001). Silicic acid, potassium|salt, Daphnia magna, acute toxicity. Final Report R-0100925,|Henkel KGaA.
Method: other: OECD Guide-line 202, part I
Short-term toxicity to aquatic invertebrates, IUC4#29/Ch.4.2
EI DuPont de Nemours & CO (1977) Toxic hazards evaluation of|five atmospheric pollutants form army ammunition plants.|AMRL-TR-77-25, ADA 043957: NTIS/OTS 0557145
Method: other: 4-NT was applied undiluted to the clipped back; kept in place by 8-ply gauze patches, latex rubber dental dam, elastoplast tape for 24 hrs; after removal tape, latex, and gauze rabbits observation for 14 d
Nellis A.A. (1956). DIMETHYLACETAMIDE. The Chemstrand Co.,|Alabama: 1-5
Salmonella typhimurium TA98 TA100 TA1535 TA1537 TA1538
Hamamoto M: Isobutylidene Diurea as a slow acting nitrogen|fertiliser and the studies in this field in Japan, The|Fertiliser Society, No. 40, 1-77 (1966)
Particle size distribution (Granulometry), IUC4#1/Ch.2.3.1
HSDB database (through 2006/06). Available online via TOXNET|at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB.
Biodegradation in water: screening tests, IUC4#22/Ch.3.5
Willford, W.A.: "Toxicity of 22 therapeutic compounds to|sixfishes"; in: "Investigation in fish control, No. 18;|Washington DC, U.S. Department of the Interior, Bureau of|Sport, Fisheries and Wildlife, 1-10, (1966);|cited in: IPCS Environ. Health Crit. 89, (1989), No information
Method: other: acute toxicity test; "static bioassay"
Short-term toxicity to fish, IUC4#36/Ch.4.1
Clariant GmbH (2000) : Dr. U. Noack Laboratorium für|Angewandte Biologie Study-No. RRA75351 (01.11.2000)
OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
Toxicity to soil macroorganisms except arthropods, IUC4#3/Ch.4.6.3
Pool, B.L. et al.: Carcinogenesis 5, 809-814 (1984), No information
Genetic toxicity in vitro, IUC4#20/Ch.5.5
Knie,J. et al., Deutsche Gewaesserkundliche Mitteilungen|27(3), 77-79, (1983)
Method: other: according Bringmann/Kuehn
van der Walle H.B. und Bensink T.: Cont. Dermat. 8,|376-382, (1982)
Cataldo DA, Ligotke MW, Harvey SD, Follows RJ, Li SW, Van|Voris P and Wentsel RS (1990). Acute Environmental Toxicity|and Persistence of DEM, A Chemical Agent Simulant: Diethyl|Malonate, NTIS/DE 91009248, 61 pp.; from: Energy Res. Abstr.|No. 13484
Toxicity to terrestrial plants, IUC4#1/Ch.4.6.2
Trochimowicz, H.J., Moore B.L. and Chiu, T. Subacute|inhalation toxicity study on eight fluorocarbons., Tox. app.|pharmacol., abstract from sixteenth annual meeting, 198-199,|1977.
Repeated dose toxicity: inhalation, IUC4#6/Ch.5.4
Helm AG (1999). Material safety data sheet according to|91/155/EEC, last update 16 Sep 1999.
Melting point/freezing point, IUC4#8/Ch.2.1
Salmonella typhimurium, TA 98, TA100, TA1537
Belyaev VA and Kuznetsov AV (1969) Hygienic standard for|3,4-dichloronitrobenzene vapor in the air of working|premises. Hyg Sanit 34: 211 - 214
Sugai S. et al. (1990). J. Toxic. Sci. 15,245.
Blum et al. (1991) A database of chemical toxicity to environmental bacteria and its use in interspecies comparisons and correlations. Journal of the Water Pollution Control Federation 63(3):196-207.
S. typhimurium TA 98, TA 100, TA 1535, TA 1537, E. coli WP2 uvrA.
BASF AG (1990). Department of Ecology,|Algenzellvermehrungshemmtest; unpublished study, (1108/87).|13 December 1990 [in German].
Method: other: Scenedesmus-Zellvermehrungs-Hemmtest, DIN 38412 Teil 9, Bestimmung der Hemmwirkung von Wasserinhaltsstoffen auf Gruenalgen
Tsulaya, V.R. et al.: Gig. Sanit., 5, 6-9, (1978) as cited in IUCLID.
Repeated dose toxicity: inhalation, IUC4#50/Ch.5.4
Tuazon E.C. and Atkinson, R., Tropospheric transformation|products of a series of hydrofluorocarbons and|hydrochlorofluorocarbons, J. Atmos. Chem. 17 (2), 179-199,|1993||Edney, D. and Driscoll, D.J., Chlorine initiated|photooxidation studies of hydrochlorofluorocarbons (HCFCs)|and hydrofluorocarbons (HFCs): Results for HCFC-22, HFC-41,|HCFC-124, HFC-125, HFC-134a, HCFC-142b and HFC-152a, J.|Atmos. Chem., 24, 1067-1081, 1992
Phototransformation in air, IUC4#5/Ch.3.1.1
Method: other: according Probst et al.: Environm. Mutagen 3, 11-32 (1981)
Genetic toxicity in vitro, IUC4#6/Ch.5.5
Bayer AG (1964). Toxikologische Untersuchungen mit|Laurinlactam, Wuppertal (unpublished)
Stamm, A. (1980): Der Einfluss von Sulfit auf das Wachstum|und die CO2-Fixierung einzelliger Grünalgen. Environ.|Pollut. (Ser. A) 22, 91-99
Toxicity to aquatic algae and cyanobacteria, IUC4#30/Ch.4.3
Cooney, J.J., L. de Rome, O. Laurence, and G.M. Gadd. 1989. Effects of Organotin and Organolead Compounds on Yeasts. J. Industr. Microbiol. 4:279-288.
BASF AG (1975): Unpublished results. Medizinisch-Biologische|Forschungslaboratorien. Gewerbetoxikologische Vorprüfung von|beta-Naphthol. Unveröffentlichter Bericht Nr. XXV/389 (in|German).
Sharpless, G.R., Sabol, M., Anthony, E.K. and Argetsinger,|H.L. (1942) Goitrogenic action of calcium and vitamin D. J.|Nutr., 25, 119-126.
Dow Corning Corporation (2004) Non-Regulated Study:|Seven-Day Range-Finding Toxicity Study of|Ethyltriacetoxysilane in Sprague-Dawley Rats. Study No.|9892-102, Sponsored by Silicone, Environmental Health|Council, Reston, VA 20190.
Developmental toxicity / teratogenicity, IUC4#1/Ch.5.8.2
Ouyang Guoshun, et al., Gongye Weisheng Yu Zhiyebing, 16|(1), 1-6 (1990)
BASF AG, Department of Toxicology, unpublished results,|Proj. No. 44RO544/90078, 07 July 1993
Method: other: Directive 87/302/EEC, part B, p. 24, 1988, OECD 414, EPA OTS 798.4900
Developmental toxicity / teratogenicity, IUC4#17/Ch.5.8.2
Dowden BF, Bennett HJ (1965). Toxicity of selected chemicals|to certain animals. Journal WPCF, 37, 1308-1316.
Method: other: according to Freeman (1953).
Short-term toxicity to fish, IUC4#3/Ch.4.1
ECOSAR model (v.0.99g). EPISUITE v. 3.11. U.S. Environmental Protection Agency, 2000
Short-term toxicity to aquatic invertebrates, IUC4#30/Ch.4.2
Hansch, C. et al. (1995) cited in KOWWIN version 1.65
Loeser, E., Bayer AG data, Untersuchungen zur Haut- und|Schleimhautvertraeglichkeit (1977)
Skin irritation / corrosion, IUC4#2/Ch.5.2.1
Cheng J.Y. and Antia N.J., Enhancement by glycerol of|phototrophic growth of marine planktonic algae and its|significance to the ecology of glycerol pollution, J. Fish.|Res. Board Can. 27 (2): 335-346, 1970 (100)
Toxicity to aquatic algae and cyanobacteria, IUC4#3/Ch.4.3
Nakamura, S. et al.: Mutat. Res. 192, 239-246 (1987);|cited in: RIFM database, location no. 6708
Genetic toxicity in vitro, IUC4#86/Ch.5.5
Guerra R (2001). Ecotoxicological and chemical evaluation of|phenolic compounds in industrial effluents. Chemosphere|44(8), 1737-1747.
Method: other: Rotifer Toxicity Screening Test for Estuarine and Marine Waters
Short-term toxicity to aquatic invertebrates, IUC4#15/Ch.4.2
Ciba (1989i). Terrestrial Plants: Growth Test with TK 10027.|Unpublished report # 894083. August 17, 1989.
OECD Guideline 208 (Terrestrial Plants Test: Seedling Emergence and Seedling Growth Test)
Toxicity to terrestrial plants, IUC4#2/Ch.4.6.2
Bringmann,G., Zeitschrift fuer Wasser- und|Abwasser-Forschung 11(6), 210-215, (1978)
Method: other: cell proliferation inhibition test
Toxicity to microorganisms, IUC4#20/Ch.4.4
Wang W (1986) Environ Pollut Ser B Chem Phys, 11, 1-14
Method: other: Aquatic plant toxicity test
Toxicity to aquatic algae and cyanobacteria, IUC4#16/Ch.4.3
Patty FA (ed.). Industrial Hygiene and Toxicology, 2nd edition, p. 1918, (1963); Patty, p. 2359-2375, (1981); Patty, p. 3068, (1994).
Skin irritation / corrosion, IUC4#3/Ch.5.2.1
Tsunogai S (1971) Oxidation rate of sulfite in water and its|bearing on the origin of sulfate in meteoric precipitation.|Geochemical Journal 5, 175-185
Bayer AG data, Report No. 12848: o-Nitrochlorbenzol:|Salmonella/Mikrosomem-Test zur Untersuchung auf|punktmutagene Wirkung, August 9, 1984
Genetic toxicity in vitro, IUC4#1/Ch.5.5
Annelin, R.B. and C.D. McKinney (1978). Dow Corning|Corporation, Report No. 1978-I0005-0589.
Dubick, M.A. and Majumdar, A.P.N.: Proc. Soc. Exp. Biol.|Med. 191 (2), 153-158 (1989);|cited in: RIFM database, location no. 13843
Repeated dose toxicity: oral, IUC4#5/Ch.5.4
TGD, 2003, Technical Guidance Document, European Commission,|May 2003
Method: other: calculated according to Veith et al. (1979) as cited in the TGD (2003)
Bioaccumulation: aquatic / sediment, IUC4#1/Ch.3.7
ECETOC Monograph. (1995). Technical Report No. 64. The toxicology of glycol ethers and its relevance to man. August 1995. European Centre for Ecotoxicology and Toxicology of Chemicals. Brussels, Belgium.
Clariant GmbH (2001): (Study-No. TNC75353, Dr. U.|Noack-Laboratorium für angewandte Biologie (03.05.2001)
Toxicity to terrestrial plants, IUC4#25/Ch.4.6.2
EPIWIN (1999). Estimation Program Interface for Windows,|version 3.04. Syracuse Research Corporation, Syracuse, NY,|USA.
Calvert, G.M., Mueller, C.A., Fajen, J.M., Chrislip, D.W.,|Russo, J., Briggle, T., Fleming, L.E., Suruda, A.J.,|Steenland, K., 1998. Health effects associated with sulfuryl|fluoride and methyl bromide exposure among structural|fumigation workers. Am. J. Public Health, 88(12):1774-1780.
Method: other: Micronuclei measured in peripheral lymphocytes and orogharyngeal cells
Grillo, C.A. & Dulout, F.N. (1995): Mutation Research 345,|73-78
Genetic toxicity in vitro, IUC4#288/Ch.5.5
Osterberg, R.E. et al.(1977), J. Toxicol. Environ. Health 3,|969-977.
Method: other: Federal Hazardous Substance Act Regulation 1973
BASF AG (2002). GKA Analytik. Physico-chemical properties of|formic acid. Report No. 02L00109, 27 Mar 2002, unpublished.
Method: other: OECD-Guideline for the Testing of Chemicals, Proposal for a new Guideline 121. Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High-Performance Liquid Chromatography (HPLC), January 2001.
Adsorption / desorption, IUC4#1/Ch.3.3.1
F. Hoffmann-La Roche Ltd, Internal Physical Properties|Database.
Method: other (measured): no data on method used
NIOSH (1992) Registry of toxic effects of chemical substances, STN online.
Skin irritation / corrosion, IUC4#6/Ch.5.2.1
Chung JW, Webster DA, Pagilla KR, Stark BC (2001).|Chromosomal integration of the Vitreoscilla hemoglobin gene|in Burkholderia and Pseudomonas for the purpose of producing|stable engineered strains with enhanced bioremediating|ability. J. Ind. Microbiol. Biotech. 27, 27-33.
Method: other: Batch degradation experiments
Biodegradation in water: screening tests, IUC4#160/Ch.3.5
Haworth, S., et al., Salmonella Mutagenicity Test Results|for 250 Chemicals, Environmental Mutagenesis, Supplement 1,|3-142, 1983 (103).
Merck-Schuchardt - Hohenbrunn, Germany. 2000. Safety Data Sheet. Trichloromethyltin for synthesis. The Merck Chemical Database - online. http://www.merck.de (accessed October 17, 2000).
BASF (2007) o-TDA - Determination of the inhibitory effect on the cell multiplication of unicellular green algae
Giddings (1980): Govt. Report Announce, Index Issue 18 US|NTIS Conf. 800223-2, 130
Toxicity to aquatic algae and cyanobacteria, IUC4#5/Ch.4.3
American Public Health Association (1971): Standart methods|for the examination of water and wastewater. 13th ed.,|American Public Health Association, Washington DC.
Method: other: American Public Health Association, 1971
Short-term toxicity to aquatic invertebrates, IUC4#13/Ch.4.2
Oldersma, H., A.O. Hanstveit, and J.M. de Wolf, Butyltrichlorostannane (CAS# 1118-46-3): Determination of the effect on the growth of the fresh water green alga Scenedesmus subspicatus. TNO Report No. V2494/04. September 2003.
Alabaster, J.S.: Int. Pest. Control 11, 29-35 (1969)|cited in: IPCS Environ. Health Crit. 89, (1989), No information
Short-term toxicity to fish, IUC4#41/Ch.4.1
Salmonella typhimurium strains TA92, TA1535, TA100, TA1537, TA94, TA98
Zissu D (1995). Histopathological changes in the respiratory|tract of mice exposed to ten families of airborne chemicals.|J. Appl. Toxicol. 15, 207-213.
Repeated dose toxicity: inhalation, IUC4#8/Ch.5.4
Mattson, V.R., J.W. Arthur, and C.T. Walbridge (1976) Acute|Toxicity of Selected Organic Compounds to Fathead Minnows.|Ecol Res Ser EPA-600/3-76-097, Environ Res Lab, US EPA,|Duluth, MN: 12; Reference Number: 719.
Short-term toxicity to fish, IUC4#6/Ch.4.1
Food and Drug Research Laboratories, Inc. (1972):|Teratologic Evaluation of FDA 71-41 (Hydrated calcium|silicate). Prep. for: FDA, U.S. Food and Drug|Administration; NTIS, National Technical Information|Service, U.S. Department of Commerce,|USA, PB 221 801, 29 Dec. 1972 [Degussa AG-No. 72-0023-FKR]
Laham et al., Drug Chem. Toxicol. 6, 363-377 (1983)
Repeated dose toxicity: oral, IUC4#80/Ch.5.4
Degussa AG (2002a). Unpublished calculation using standard|methods / equations.
Method: other (calculation): PCKowWin Version 1.66 as integrated in EpiWin Version 3.10 (first-order molecular connectivity index (1-MCI) method), Syracuse Research Center / U.S. EPA
Adsorption / desorption, IUC4#3/Ch.3.3.2
CIBA-GEIGY, Ltd. 1983. Sister chromatid exchange studies on somatic cells of Chinese hamsters. Report Nr. 830521. Basle, Switzerland. November 9, 1983.
Butterworth BE, Doolittle DJ, Working PK, Strom SC, Jirtle|RL, Michalopoulos G (1982) Chemically-induced DNA repair in|rodent and human cells. Banbury Report No 13, Vol 31:|101-114
Method: other: according to Mirsalis, Carcinogenesis 1, 621 (1980), 12 hrs after application of TS, hepatocytes were isolated, cultured in the presence of 3H-TdR; incorporation of label measured by quant. autoradiography, pos. and neg. control
IIT Research Institute. 1991. Acute Dermal|Irritancy/Corrosivity Study of Trimellitic Anhydride in|Rabbits. Study No. 1694
Skin irritation / corrosion, IUC4#1/Ch.5.2.1
Hilton, J. et al.: Food Chem. Toxicol., 34, 571-578, (1996), No information
Toxicity to reproduction, IUC4#8/Ch.5.8.1
Hazleton Laboratories America, Inc. (1983) In Vitro Sister|Chromatid Exchange in Chinese Hamster Ovary Cells with|Methyl Mercaptoprionate. Project No. 652-147.
Method: other: similar to OECD 479 and OPPTS 870.5900
Eastman Kodak (1981). BOD5 & COD of photographic chemicals|(Druckschr. J-41), 12 pp as cited in Janicke, W. (1983):|WaBoLu-Berichte 1/83, 3, 5, 7-31, 47.
Biodegradation in water: screening tests, IUC4#2/Ch.3.6
Salmonella Typhimurium TA1535, TA1537, TA1538, TA98, TA100
Fukushima S. et al.: Jpn. Cancer Res. 82, 642-649, (1991)
Method: other: Wide spectrum organ carcinogenesis model using F344 rats
LANGE's Handbook of chemistry (15th edition), table|1.15,1999 by McGraw-Hill
Melting point/freezing point, IUC4#1/Ch.2.1
Allium cepa, Chara zaylanca, Tulbaghia violacea
Pharmakon Research International, SanSebastian J (1988) In|Vivo Bone Marrow Cytogenetics Rat Metaphase Analysis PH|315-MO-001-87 (Monsanto PK 87-316), Santoflex 13.|Unpublished study of Monsanto Chemical Co. NTIS/OTS 546286,|EPA/OTS document # 88-920008736
Physical properties of glycerine and its solutions,|Glycerine Producers Association, 1955 (102).
Stankowski Jr., L.F. et al: Environ Mutagen. 9, 102 (1987);|abstract no. 264, No information
Genetic toxicity in vitro, IUC4#120/Ch.5.5
Cieszlak, FS and Crissman, JW (1991). Dowanol* PM glycol ether: An acute vapor inhalation study in Fischer 344 rats. Unpublished report of The Dow Chemical Company
Acute toxicity: inhalation, IUC4#7/Ch.5.1.2
O'neil, M.J., Smith, A. and Heckelman, P.E. (eds.) (2001)|The Merck Index, 13th ed., Merck & Co., Inc., Whitehouse|Station, NJ.
Melting point/freezing point, IUC4#10/Ch.2.1
BASF AG (1980). Department of Ecology, Biodegradation, Unpublished Report, 1 February 1980.
OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
Method: other: according to Heddle, J.A. et al.: in: Kilbey, B.J. et al. (eds): Handbook of Mutagenicity Test Procedures, 2nd ed., Amsterdam, Elsevier, 441-458, (1984)
An inhalation range-finding developmental toxicity study in|rabbits with HCFC-124. Bio/dynamics Inc., Millstone, New|Jersey, Project No 89-3513. June 1991. Study performed for|PAFT III.
Developmental toxicity / teratogenicity, IUC4#4/Ch.5.8.2
Simmon, V.F. (1979), "In Vitro Assays for Recombinogenic|Activity of Chemical Carcinogens and Related Compounds with|Saccharomyces Cerevisiae D3", J. Natl. Cancer Inst., Vol.|62, No. 4, pp. 901-909
Genetic toxicity in vitro, IUC4#9/Ch.5.5
Tomida, Yotsiyanag, Ikeda. (1978): Chem Pharm Bull 261,|2824-2831| transplacental transport of terephthalic acid in|Fischer-344 rats. Drug Metab Dispos 10, 486-490
Hoechst AG (1989): Produktinformation Natriumsulfit|wasserfrei der Abt. Verkauf Chemikalien (Juni 1989)
Melting point/freezing point, IUC4#30/Ch.2.1
BIBRA (1988) A 28-day study in rats with thioglycolic acid,|2-ethylhexyl ester including investigations of hepatic|peroxisomal activity. Report # 689/1/88.
Method: other: equivalent to OECD Guide-line 407
Repeated dose toxicity: oral, IUC4#2/Ch.5.4
Cieszak, FS et al. (1998) Propylene glycol monomethyl ether: A 2-year vapor inhalation chronic toxicity/oncogenicity study and evaluation of hepatic and renal cellular proliferation, P450 enzyme induction and protein droplet nephropathy in Fischer 344 rats. Unpublished report (in preparation) of The Dow Chemical Company (sponsored by the Chemical Manufacturers Association P-Series Glycol Ethers Panel, Arlington, VA.
OECD Guideline 453 (Combined Chronic Toxicity / Carcinogenicity Studies)
Auer Technikum/Auergesellschaft, Berlin, Ausg. 12 (1988), No|1001
Allyl chloride - Safety data (1989), Polymer and Chemical|Intermediates Manual PCI 3.1, May.
Saccharomyces cerevisiae D-3, see p. 123/124
Schmidt P, Fox G, Hollenbach K und Rothe R (1974) Zur|akuten Toxizität des Thioglykolsäure-2-äthylhexylesters im|Tierversuch, Zeitschrift fur die Gesamte Hygiene und ihre|Grenzgebiete, 20, 575-578.
Repeated dose toxicity: dermal, IUC4#5/Ch.5.4
Rowe VK et al. (1954) Arch Ind Hyg Occup Med, 9, 509-525.
Budavari, S. (ed.), The Merck Index. An encyclopedia of|chemicals, drugs, and biologicals. 11th ed., Rahway, New|Jersey, 1357 (1989)
Hinton, R.H. et al. (1990): Toxicologist 10, 297
Bertelo, C. 2001. Determining the solubility and rate of hydrolysis of organotin compounds. Internal industry report. ATOFINA Chemicals, Inc. November 30, 2001.
Gotoh H. et al. (1988). Mutation Res. 199, 55.
Chemicals Evaluation and Research Institute (CERI), Japan (2001). Unpublished report
Method: other (calculated): AOP WIN Ver. 1.90
BASF AG (2007). Spectroscopic characterization and|determination of physico-chemical properties of "Formic|acid". GKA Competence Center Analytics, Ludwigshafen/Rhein,|Germany, Study No. 07L00084, 06 Jul 2007 (unpublished).
Lead chromate molybdate sulphate red (C.I. Pigment Red 104)
Smyth HF JR, Carpenter CP, Weil CS, Pozzani UC, Striegel JA|(1962) Range-Finding Toxicity Data List VI. Am Ind Hyg Ass J|23: 95-107
Method: other: according to Draize et al., J.Pharmacol.Exper.Therap. 82, 377 (1944), see also freetext TC
KEMI Report No. 11/94. 1994. Mono- and Di- Substituted Organotins Used as Plastic Additives. L. Freij (ed.). Volume 1. Environmental Hazard Assessment. The Swedish National Chemicals Inspectorate. p. 13.
Bioaccumulation: aquatic / sediment, IUC4#2/Ch.3.7
Bayer AG 1979, Internal study 7900802-815: Biodegradation|p-Nitrochlorobenzene (Internal report written 2002.05.07)
Reported in AIDA (13/11/92)-ALSTOFF INFORMATION Date Bank|from BASF AG (312186), Analytical Laboratory-Unpublished|Data.
BASF AG (no date) Phys.-Anal. Laboratory, M 325,|determination of the Vapor Pressure, unpublished.
Litton Bionetics, Inc.: Mutagenic evaluation of compound FDA|71-41, calcium silicate. Prep. for: FDA, U.S. Food and Drug|Administration; NTIS, National Technical Information Servi-|ce, U.S. Department of Commerce, Springfield, VA, USA,|PB-245 457 (1974)
BASF AG (1985). Department of Ecology, report J.No.|18365/85, study No. 1277, 03 Dec 1985, unpublished.
Method: other: following OECD 302 B (Zahn Wellens Test)
IITRI. 1987. Dermal sensitization study of trimellitic|anhydride (TMA) in guinea pigs. Final Report. IITRI Project|No. L8100, Study No. 1196, Test Article No. 128.
Glauert HP, Wendy SK, Sattler GL, Pitot HC (1985) Assays to|measure the induction of unsheduled DNA synthesis in|cultered hepatocytes. Prog Mut Res 5: 371-373
Method: other: according Althaus et al., 1982, Cancer Res. 42, 3010
Genetic toxicity in vitro, IUC4#107/Ch.5.5
Sodemoto, Y. & Enomoto, M., J. Environ. Pathol. Toxicol. 4,|87-95 (1980)
Lomonova GV (1963). On the toxicity of cyclohexylamine and|dicyclohexylamine. Gig. Tr. Prof. Zabol 7, 51-56.
Method: other: single exposure to dicyclohexylamine in concentrations from 0.11 to 0.25 mg/l for probably 2 hours
Gigiena i Sanitaria 30, p.22 (1965). As cited in: The|Registry of Toxic Effects of Chemical Substances (RTECS).|2-Naphthol. RTECS# QL2975000. Update July 2000.
Repeated dose toxicity: oral, IUC4#7/Ch.5.4
Hoechst AG (1980): Unveroeffentlichte Untersuchung|(17.11.1980)
BASF AG, Abteilung Toxikologie; unveroeffentlichte|Untersuchung (VII/310), 21.07.1958
Acute toxicity: dermal, IUC4#22/Ch.5.1.3
Elf Atochem NA. 1999. Material Safety Data Sheet. Thermolite (R) 31 Stabilizer. Revision 2. Issued 22 October 1999.
Mailhes, J.B. et al.: Mutagenesis 11 (4), 395-399 (1996)
Method: other: according to Mailhes, J. and Yuan, Z.P.: Gamete Res. 17, 77-83
Genetic toxicity in vivo, IUC4#57/Ch.5.6
Bills, D. et al.: "Investigation in fish control. 73.|Formalin, its toxicity to nontarget aquatic organisms,|persistence and counteraction"; Washington DC, U.S.|Department of the Interior, Fish and Wildlife Service, 1-7,|(1977);, No information
Method: other: acute toxicity test; "flow through bioassay"
Short-term toxicity to fish, IUC4#13/Ch.4.1
Adema DMM, Canton JH, Slooff W, Hanstveit AO (1981).|Onderzoeknaar een geschikte combinatie toetsmethoden ter|bepaling van de aquatische toxiciteit van milieugevaarlijke|stoffen (Rapport nr.: CL 81/100, RIV 627905 001) [Adema DMM,|Canton JH, Slooff W, Hanstveit AO (1981) Research for a|Useful Combination of Test Methods to Determine the Aquatic|Toxicity of Environmentally Dangerous Chemicals. Consecutive|System of Rep.No.CL81/100, Natl. Inst. Public Health|Environ. Hyg., 107 pp.].
Method: other: according to a dutch national standard method: NEN 6504, 1980 (Wateronderzoek. Bepaling van de acute toxiciteit met Poecilia reticulata)
Long-term toxicity to fish, IUC4#9/Ch.4.5.1
Slesinski, R.S. and P.J. Guzzie. 1988. Organofunctional|Silane A-1120 In Vitro Gentoxicity Studies: CHO/HGPRT Gene|Mutation Test/Sister Chromatid Exchange Assay. Bushy Run|Research Center Project Report 51-51, August 15, 1988.
Method: other: EPA Health Effects Test Guidelines, HG-Gene Muta-Somatic cells, EPA Report No. 560-83-001, October 1983
Genetic toxicity in vitro, IUC4#13/Ch.5.5
Dolich. T. (2003), Hydrolysis as a function of pH of|Epsilon-caprolactone. BASF GKA Analytik, Study No. 03L00213
Union Carbide Corporation. 1992b. Ecological Effects Data on|Carbide Products and Process Chemicals. South Charleston,|WV. 25303. (6.12.92).
BioReliance (2006) In Vitro Mammalian Chromosome Aberration|Test with Trimethoxysilane (CAS Number 2487-90-3)|BioReliance Study Number AB34WR.331.BTL
Salmonella typhimurium TA98, TA100, TA1535, TA1538
Waalkens-Berendsen, D.H. 2004. Tetraoctylstannane (CAS # 3590-84-9): Combined oral repeated dose toxicity study with the reproduction/developmental toxicity screening test in rats. TNO Report V4905. 29 January 2004.
Crespi, C.L. et al., Prog. Mutat. Res. 5, 497-516 (1985)
Bayer AG (1976). Internal information card of C.I.|Fluorescent Brightener 28/113 (89 % free acid).
Biodegradation in water: screening tests, IUC4#40/Ch.3.6
Jenner P., et al., 1964, Food flavourings and compounds of related structure I. acute oral toxicity, Fd Cosmet. Toxicol. 2:327-343
"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold,|J., Prague, Czechoslovakia, Avicenum, p.1054 1986, in RTECS,|2001 version
Nair R.S., (1983), Ortho-nitroaniline 4-week inhalation|toxicity study in male rats: Unveroeffentichte Ergebnisse|der Monsanto; Zitert in:BUA-Stoffbericht Nr 28 (1988)
Repeated dose toxicity: inhalation, IUC4#1/Ch.5.4
EU Method C.2 (Acute Toxicity for Daphnia)
Short-term toxicity to aquatic invertebrates, IUC4#20/Ch.4.2
BASF AG, Department of Toxicology, Report on the study on|the corrosivity of Prenol after 1 and 4 exposure,|unpublished report (78/453), 23 April 1979
Korhonen et al. (1983) Acta Pharmacol. 52:95-99.
Developmental toxicity / teratogenicity, IUC4#7/Ch.5.8.2
Ishidate M Jr, Harnois MC, Sofuni T (1988) A comparative|analysis of data on clastogenicity of 951 chemical|substances tested in mammalian cell cultures. Mutat Res 195:|151-213
Method: other: chromosomal aberration test ( see freetext TC)
Genetic toxicity in vitro, IUC4#100/Ch.5.5
Verschueren K (1996) Handbook of Environmental Data on|Organic Chemicals (3. ed.) Van Nostrand Reinhold, New York,|1306 - 1307
Bringmann, G. & Kuehn, R., Z. Wasser Abwasser Forsch. 10|(1977), 161-166 (72).
Short-term toxicity to aquatic invertebrates, IUC4#2/Ch.4.2
Miller EG, Washington VH, Bowles WH, Zimmermann ER (1986)|Mutagenic potential of some chemical components of dental|materials. Dent Mater 2: 163-165
Method: other: according to Maron et al., Mutat. Res. 113, 173 (1983), plate incorporation methodology, DMSO as neg. contr., pos. contr: 4-nitroquinoline-N-oxide,2-aminofluorene
Genetic toxicity in vitro, IUC4#37/Ch.5.5
Comptes Rendus Hebdomadeires des Seances, Academie des Sciences (Paris, France). 1954. Vol 239, V. 1-261, 1835-1965.
USEPA. 2000. EPIWIN (Estimation Program Interface for Windows). Version 3.12. Office of Pollution Prevention Toxics (OPPTS) and Syracuse Research Corporation.
Snyder, R.D. and Van Houten, B.: Mutat. Res. 165, 21-30|(1986), No information
Method: other: Nick translation assay (DNA strand breaks)other: in vitro DNA damage - eukaryotes (mammalian cells/DNA strand breaks)
Genetic toxicity in vitro, IUC4#184/Ch.5.5
Salmonella typhimurium TA 1535, TA 1537, TA 1538, TA 98, TA 100
BASF AG (2003). Safety data sheet TRIPHENYLPHOSPHINE FLAKES, 04.11.2003
Melting point/freezing point, IUC4#3/Ch.2.1
Merck Index (2001). Budavari S. (ed.) - An Encyclopedia of|Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ,|Merck and Co., Inc., No. 283
American Chemistry Council (2001). Rubber and Plastic Additives Panel, HPV Chemical Challenge Program Submission, Sulfenamide Accelerators Category: Category Justification and Testing Rationale
Short-term toxicity to fish, IUC4#50/Ch.4.1
Ishidate, M. jr. and Yoshikawa, K.: Arch. Toxicol. 4, 41-44|(1980);|cited in: RIFM database, location no. 9350
Genetic toxicity in vitro, IUC4#79/Ch.5.5
Toze S, Patterson B, Zappia L, Power T, Davis GB (1999). The|effect of sorption and biodegradation on the migration of|munition compounds in groundwater and soil environments. In:|Proceedings of the Contaminated Site Remediation Conference,|Contaminated Site Remediation: Challenges Posed by Urban and|Industrial Contaminants. Freemantle, 375-381.
Method: other: as described by Patterson (1996)
Adsorption / desorption, IUC4#2/Ch.3.3.1
Hoechst AG (1980) Akute Toxizität von Nitro-o-dichlorbenzol|asym. an Goldorfen (Leuciscus idus f. melanotus) Unpublished|Internal Study 531/80
Method: other: DIN 38412 L 15 (Fish, short-time test)
Short-term toxicity to fish, IUC4#11/Ch.4.1
McGregor, D. B. et al.: Environ. Mutagen. 12, 85-154 (1988)
Genetic toxicity in vitro, IUC4#15/Ch.5.5
Fanelli, G.M. & Halliday, S.L., Arch. Int. Pharmacodyn.|144, 120-125 (1963)
Green W.J., Lee G.F., Jones R.A., Clay-soils permeability|and hazardous waste storage, Journal WPCF 53 (8) 1347-1354,|1981 (16)
Adsorption / desorption, IUC4#3/Ch.3.3.1
Dow Europe SA (1983) "Bacterial mutagenicity test on DOWANOL PM", unpublished report.
Brooks T.M. et al., Mutagenesis, 3, 227-232, 1988
Report No. EAI98002, Environment Agency, Japan (1999d):|unpublished report
Method: other: calculation, ECOSAR v0.99g
Long-term toxicity to aquatic invertebrates, IUC4#2/Ch.4.5.2
Annelin, R.B. and J.E. Cerro. 1978. Dow|Corning Corporation, Report No. 1978-I0005-0581.
Kurokawa, Y., Takayama, S., Konishi, Y., Hiasa, Y., Asahina,|S. Takahashi, M., Maekawa, A. and Hayashi, Y. (1986):|Long-term in vivo carcinogenicity tests of potassium|bromate, sodium hypochlorite and sodium chlorite conducted|in Japan. Env Health Perspectives, 69, 221-235.
Method: other: essentially the same as National Cancer Institute (1975). Bethesda, MD
Jaber HM, Mabey WR, Liu AT, Chou TW, Johnson HL, Mill T, Podoll RT, Winterle JS (1984). Data acquisition for environmental transport and fate screening. US EPA/NTIS PB84-243955, EPA-600/6-84-009, p. 208.
Phototransformation in air, IUC4#20/Ch.3.1.1
Motoyoshi K., Toyoshima Y, Sato M., et al., 1979, Comparative studies on the irritancy of oils and synthetic perfumes to the skin of rabbit, guinea pig, rat, miniature swine and man, Cosm. Toil. 94: 41-48
BASF AG, Department of Toxicology, unpublished data, details|on an eye irritation/corrosion study in rabbits, Glyecin A;|BASF Report XVI/109 (13.June 1966) and the original|laboratory raw data, 13. April 2004
Darroundi F, Natarajan AT (1983) Cytogenetic analysis of uman peripheral blood lymphocytes (in vitro) treated with resorcinol. Mutation Research 124:179-189.
Genetic toxicity in vitro, IUC4#32/Ch.5.5
Miller,D.C. et al., Arch. Environ. Contam. Toxicol. 19,|40-48, (1990)
Short-term toxicity to fish, IUC4#2/Ch.4.1
Union Carbide Corp. Bushy Run Research Center,|Project Report No.14-73. Export, PA. 1951.
Method: other: Internal Union Carbide method for inhalation exposure.
Defitraces (2003) Report No. 02-902003-064. Freezing point|of EHTG. April 3, 2003.
OECD Guideline 102 (Melting point / Melting Range)
BASF AG (1979). Department of Toxicology. Bericht über die Prüfung der Ätzwirkung von "AEEA-S" am Kaninchen nach 4- und 1-stündiger Einwirkungsdauer, (77/715), unpublished data, 23 Aug 1979.
Verschueren K. 1996. Handbook of Environmental Data on Organic Chemicals. 3rd Ed. John Wiley & Sons, Inc. p. 768.
Biodegradation in water: screening tests, IUC4#1/Ch.3.6
McKim, J.M. et al.: J. Water Pollut. Control Fed. 48,|1544-1620 (1976);|cited in: IPCS Environ. Health Crit. 89, (1989), No information
Short-term toxicity to fish, IUC4#70/Ch.4.1
Bringmann G, Kühn R (1977) Befunde der Schadwirkung|wassergefährdender Stoffe gegen Daphnia magna. Z Wasser|Abwasser Forsch 10 (5): 161 - 166
Short-term toxicity to aquatic invertebrates, IUC4#50/Ch.4.2
USEPA. 2000. MPBPWIN. Version 1.40. Estimation Programs Interface (EPI) Suite. Office of Pollution Prevention Toxics (OPPTS) and Syracuse Research Corporation.
Method: other (calculated): MPBPWIN v1.40
Research Triangle Institute, Project No. 60C-4652, August 10 (1992) (at the request of the Synthetic Organic Chemical|Manufacturers Association)
Toxicity to reproduction, IUC4#2/Ch.5.8.1
Eastman Kodak Company (1993) Material Safety Data Sheet and |Acute Toxicity Studies with Hexamethyldisilizane with Cover|Letter Dated 061493. Microfiche No. OTS0537734 Document ID|8690000298.
Monsanto (1977). Birch MD. Phosphorus trichloride acute oral|and dermal toxicity and skin and eye irritation. Younger|Laboratories inc. St Louis, Mo, USA. Project No Y-76-401; 17|Jan 1977 OTS 0534 845.
Callander RD (1982). 4,4' dichlorodiphenyl sulphone - An evaluation in the Salmonella/micosome mutagenicity assay. ICI PLC, Central Toxicology Laboratory, Report No. CTL/P/723.
Shamberger RJ (1971). Inhibitory effect of vitamin A on|carcinogenesis, J. Nat. Cancer Inst. 47, 667-673
TSCAT, OTS0540076; Doc 88-920003588; 16 Jun 1992. Skin|irratancy. With cover letter dated from 04 Jun 1992 and|attachment from Bushy Run Research Center, report dated 21|May 1990; Sponsor: Union Carbide Co., USA.
Acute toxicity: dermal, IUC4#10/Ch.5.1.3
Jones, et al. 1935. J. Chem. Soc. 41-45.
Butler MA, DeBord DG, Cheever KL, Werren, DM, Swearengin TF|(1993) Detection of DNA adduct formation in rats by the 32P|post-labelling assay following exposure to o-toluidine.|Carcinogenesis 34: 137
Genetic toxicity in vivo, IUC4#16/Ch.5.6
Takahashi, O. (1986) Arch. Toxicol. 58, 177-181
Repeated dose toxicity: oral, IUC4#47/Ch.5.4
CIBA-GEIGY Ltd. 1993. Report on the acute toxicity test of Irgastab 17M to Zebra-Fish (Brachydanio rerio). Test No.: 928307. Basle, Switzerland. 29/01/93.
Fukuhara, T. Fujii, N. Watanabe (1978c). Fujisawa|Pharmaceutical Co. Ltd, Central Laboratory. Teratogenicity|study of glucono-delta-lactone in mice (Oral dosing).
Bushy Run Research Center (1981) Organofunctional |Silane A-166: Acute Toxicity and Primary Irritancy |Studies, Bushy Run Research Center, Project Report|44-110, 12/21/81. Cited in NISC and BiblioLine (2009)|BiblioLine - www.nisc.com
Dow Chemical USA (1980). Acute toxicological properties and|skin sensitization potential of aminoethylethanolamine. R+D|report, TXT: K-4409-(3), 13 Nov 1980.
BASF AG, Labor Oekologie; unveroeffentlichte Unter-|suchung, (Ber.v.06.03.89)
Method: other: Test for Inhibition of Oxygen Consumption by Activated Sludge, ISO 8192
Dooms-Goossens, A. et al. (1977), Turpentine-induced|hypersensitivity to peppermint oil, Contact Dermatitis 3,|304-308
FMC Corporation, Acute toxicity of ammonium persulfate to|the water flea (Daphnia Magna), Study no. I92-1248, 1993.
EPA OPP 72-2 (Aquatic Invertebrate Acute Toxicity Test)
Kalinina, Gig. Tr. Prof. Zabol. 15, 30-33 (1971)
Suntio LR, Shiu WY, Mackay D, Seiber JN and Glotfelty D|(1988). Critical review of Henry's law constants for|pesticides. Rev. Environ. Contam. Toxicol. 103, 1-59.
Malorny G (1969). Die akute und chronische Toxizität der|Ameisensäure und ihrer Formiate. Zeitschrift|Ernährungswissenschaft 9, 332-339.
Genetic toxicity in vitro, IUC4#14/Ch.5.5
Schleyer WL and Blumberg JG (1982). Health, safety and|environmental aspects of soluble silicates. In Soluble|Silicates, Falcone JS (ed). ACS Symposium Series 194,|Chapter 4, 49-69.
Method: other: FHSA Draize method specified in 16 C.F.R. 1500.42
Safepharm Laboratories Ltd. (1992). Vestamin IPD: Metaphase|analysis in CHO cells in vitro. Project No. 395/11 (Hüls AG,|unpublished).
Method: other: OECD Guideline 473 (1981)
Rudzki, E. and Kleniewska, D. (1970), The Epidemiology of|Contact Dermatitis in Poland, Br. J. Derm. 83, 543-545
Huber, M.C. et al, Bull. Environ. Contam. Toxicol.|59,292-297 (1997)
Safety Data Sheet Bayer AG (zitiert nach EUCLID Data Sheet|vom 18.08.1994, Bayer AG)
Griffith JF. Fluorescent whitening agents. Tests for|skin-sensitizing potential. Arch. Dermatol. 107, 728-733,|1973.
Method: other: human repeat insult patch test (HRIPT)
Allied Corporate Medical Affairs (1979) Bacterial Mutagenicity of Four Toluene Diamine Isomers, (1979), EPA Document No. 40-8336132, Fiche No. OTS0506071. (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com)
Imai, S., Morimoto, J., Sekiya, N., Shima, M., Kiyozuka, Y.,|Nakamori, K., Tsubura, Y. (1986). Chronic toxicity test of|KCl and NaCl in F344/Scl rats. J. Nara Med. Ass. 37:115-127.
Dunlap MK, Kodama JK, Wellington JS, Anderson HH, Hine, CH|(1958). The toxicity of Allyl Alcohol, A.M.A. Archives of|Industrial Health 18, 303-311
Heyder J, Beck-Speier I, Ferron GA, Heilmann P, Karg E,|Kreyling WG, Lenz AG, Maier K, Schulz H, Takenaka S, Tuch T|(1992) Early response of the canine respiratory tract|following long-term exposure to a sulfur (IV) aerosol at low|concentration. I. Rationale, design, methodology, and|summary. Inhal Toxicol 4: 159-174
Method: other: specific investigation of respiratory lung function
Lonza AG, unpublished report, 1973, Acute oral toxicity mouse, rat, rabbit, Consultox Laboratories Ltd , Lonza Report No. 235
BASF Corp. (1997). Chemicals Division Product Catalog.
Appearance/physical state/colour, IUC4#3/Ch.1.1.1
Deichmann, W.B. et al. (1955): Arch. Ind. Health 11, |93 - 101
Bayer AG 1984, Internal Study, Bestimmung der letalen|Wirkung beim Zebrabärbling|Brachydanio rerio, Verfahrensvorschlag des UBA, Stand|1.6.1982
Sun, Ying; Chen, Huiping; Kelly, Donald V.; Reiter, Michael|R. (2002) Determination of the Approximate Molecular Weight|of|Acetoxysilane Hydrolysis Products in Gastric Juice|Simulant-Memo Report Submitted to the Silicones|Environmental, Health and Safety Council of North America|(SEHSC); Dow Corning Corporation Technical Report No.|2002-I0000-52204, 2002.
Method: other: Experimental - no recognized guideline available
Stoner GD, You M, Morgan MA, Superczynski MJ (1986) Lung|tumor induction in strain A mice with benzotrichloride.|Cancer Letters 33: 167 - 173
Method: other: carcinogenicity after repeated i.p. treatment
BASF AG, 1974, Technical instructions. Choline chloride|solution 70% and choline chloride powder 50%, unpublished|data, Sept. 1974
Bringmann G and Kuhn R (1959) Water Toxicological Studies with Protozoa as Test Organisms. TR-80-0058, English Translation, Literature Research Company:, TR-80-0058, English Translation, Literature Research Company: 13 p.; Gesund.-Ing. 80:239-242 (GERMAN); Chem. Abstr. 53: 22630D (cited in BiblioLine(c) 1997-2006, NISC International Inc. All Rights Reserved. www.nisc.com).
Short-term toxicity to aquatic invertebrates, IUC4#52/Ch.4.2
Ishikawa T, Ose Y, and Sato T (1979). Removal of organic|acids by activated sludges. Water Research 13, 681-685.
Biodegradation in water: screening tests, IUC4#29/Ch.3.5
Eastman Kodak (1958). Toxicity report. In: TSCATS|Doc#86-920000008: Letter from Eastman Kodak Company|to USEPA submitting enclosed Toxicity & Health Hazard|Summary, Material Safety Data Sheet & Toxicity Reports on|3-hydroxy-2-naphthoic acid, 01 Oct 1991
NTP (2001). NTP Technical Report on the Toxicology and Carcinogenesis studies of p,p'-Dichlorodiphenyl sulfone in F344/N rats and B6C3F1 Mice. National Toxicology program, September 2001, NTP TR 501, NIH Publication No. 01-4435.
Melting point/freezing point, IUC4#2/Ch.2.1
BASF AG, Department of Toxicology, Bericht über die Prüfung|von S 3 im Ames-Test, unpublished report |(79/192), 08 Aug. 1979
Genetic toxicity in vitro, IUC4#7/Ch.5.5
Kristiansen, E. & Scott, D., Mutat. Res. 224, 329-332 (1989)
Hoechst AG (1996): internal calculation, Abt. SU Umwelt/|Produktsicherheit (19.04.1996)
Method: other (calculated): Epiwin Version 2.0, Syracuse Research Corporation, Environmental Science Center Merill Lane, Syracuse, NY 13210, 1996
Phototransformation in air, IUC4#7/Ch.3.1.1
Calhoun, L.L., (1986) Propylene glycol phenyl ether 28-day dermal toxicity study in rabbits. Unpublished report.
Method: other: While a specific OECD or EPA Protocol guideline was not referenced, this study followed the requirements of EPA Protocol Guideline 870.3200 "21/28-Day dermal toxicity" and OECD 410: "Repeated Dose Dermal Toxicity: 21/28 day."
Repeated dose toxicity: dermal, IUC4#1/Ch.5.4
ExxonMobil Chemical Company (2001) TEST PLAN For The|NEOACIDS C5-C28 CATEGORY (CAS# 75-98-9: Propanoic acid,|2,2-dimethyl-CAS# 598-98-1: Propanoic acid, 2,2-dimethyl-,|methyl ester CAS# 95823-36-2: Carboxylic acid, C6-8 neo CAS#|26896-20-8: Neodecanoic acid CAS# 68938-07-8: Fatty acids,|C9-C13 neo CAS# 72480-45-6: Fatty acids, C9-C28 neo).|November 15, 2001 Revised December 19, 2002.
BASF (1961) Acute toxicity and skin/eye irritation (X/211;|X/329). BASF AG, Department of Toxicology, 13.02.1961|(unpublished data)
Clive, D., McCuen, R., Spector, J.F.S, Piper, C. and|Mavournin, K.H. (1983), "Specific gene mutations in L5178Y|cells in culture", Mutation Research, 115: pp. 225-51
Genetic toxicity in vitro, IUC4#5/Ch.5.5
Secara, S.R., 1990. Methyl Bromide - Octanol/Water Partition|Coefficient. Unpublished report from Bolsa Research|Associates, Inc. BR 172:90.
Method: other (measured): 40 CFR, 796.1550 and California Notice 87-6
Reported in HSDB-Data Bank from Geiger D.L. et al. (Eds.)|(1990). Acute toxicities of organic chemical to fathead|minnows (pimephales-promelas). Vol. V. Superior WI:133.
Short-term toxicity to fish, IUC4#7/Ch.4.1
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Fukuda K (1981) Experimental carcinogenesis by the chemicals|relating to benzoyl chloride production. Ochanomizu Igaku|Zasshi 29: 69 - 81
Repeated dose toxicity: dermal, IUC4#3/Ch.5.4
Roempp (1999). Roempp Lexikon der Chemie (Electronic|Version). Georg Thieme Verlag, Stuttgart.
Melting point/freezing point, IUC4#15/Ch.2.1
EPA (2004) EPIWIN Calculations Phenol, 4-(phenylamino)-
Method: other (calculated): LOGKOW version 1.66
BASF (1981): Bericht über die Prüfung der akuten Toxizität|von Natriumpyrosulfit auf die Regenbogenforelle (Salmo|gairdneri Rich.). BASF AG, Gewerbehygiene und Toxikologie,|Proj. No. 80/339, 06.01.1981
Method: other: DIN 38 412, Testverfahren mit Wasserorganismen (Gruppe L)
Short-term toxicity to fish, IUC4#30/Ch.4.1
Mobay Chemical Corporation (1987a). The evaluation of isophorone diisocyanate for mucous membrane irritation in rabbits. NTIS/OTS Microfiche 0515404, Doc 87-870001245.
Verschueren, K.: "Handbook of Environmental Data on Organic|Chemicals", 2nd ed., Van Nostrand, New York (1983), p.1310, No information
Society of Toxicology, Technical Committee of the Inhalation Specialty Section (1992). Recommendations for the conduct of acute inhalation limit tests. Fund. Appl. Toxicol. 18, 321-327.
Acute toxicity: inhalation, IUC4#99/Ch.5.1.2
The Chemical Daily Co., Ltd., Japan (2003) The 14303|chemical products, 403-404
Hoechst AG (1995): Unveröffentl. Unters. (93-0161-22)
Thompson C.Z., Hill L.E., Epp J.K., Probst G.S. (1983), The|induction of bacterial mutation and hepatocyte unscheduled|DNA synthesis by monosubstituted anilines: Env. Muta. 5,|803-811
BASF AG, Experimental Toxicology and Ecology, unpublished study, Isobutylacrylat - Determination of the inhibitory effect on the cell multiplication of unicellular green algae,|Project No. 01/0366/60/1, 15 February 2002
Fiddler, W. et al.: IARC Scientific Publication no. 57,|95-100 (1984), No information
Genetic toxicity in vitro, IUC4#55/Ch.5.5
Seifert G (1982a). FAT 65'023/L - Acute skin irritation|study|in the rabbit. Report GU roject No. 820602, November 3,|1982. GU2 Toxicology, Ciba-Geigy Ltd., Sisseln, Switzerland.
Skin irritation / corrosion, IUC4#20/Ch.5.2.1
Method: other: in accordance with OECD Guide-line 482, no detailed data available
Zhao YH, Cronin MTD, Dearden JC (1998) Quantitative|structure-activity relationships of chemicals acting by|non-polar narcosis-theoretical considerations. Quant|Struct-Act Relat 17, 131 - 138
Toxicity to microorganisms, IUC4#170/Ch.4.4
Emtiazi G and Knapp JS (1994). The biodegradation of|piperazine and structurally-related linear and cyclic|amines. Biodegradation 5, 83-92.
Method: other: Die-away study using natural water from the River Aire (UK)
Biodegradation in water: screening tests, IUC4#8/Ch.3.5
U.S. National Library of Medicine (2001) Hazardous Substances Data Bank (HSDB)
Occidental Chemical Corporation (1990)|Orthochlorobenzylchloride 28-day inhalation toxicity study|in rats with cover letter, EPA Doc# 88-900000192,|NTIS/OTS0526421.
OECD Guideline 412 (Repeated Dose Inhalation Toxicity: 28/14-Day)
Repeated dose toxicity: inhalation, IUC4#2/Ch.5.4
Smith, C.W. and Siegel, S.M. 1975. Differential Permiation|of Artemia Cysts and Cucumber Seeds in Alcohols. J.|Histochem. Cytochem.., 23(1): 80-83. As cited in World|Health Organization (WHO). 1987. Environmental Health|Criteria 65: Butanols - Four Isomers: 1-Butanol 2-Butanol|tert-Butanol Isobutanol. WHO.
Toxicity to terrestrial plants, IUC4#20/Ch.4.6.2
Ahlstrom, R.C. Jr. and J. M. Steele: Kirk-Othmer|Encyclopedia of Chem Tech., 5, 3rd Ed., 677-685 (1979).
Jakab, G.J.: Inhalation Toxicology 4, 325-342 (1992), No information
Repeated dose toxicity: inhalation, IUC4#22/Ch.5.4
Gocke, E. et al.: Mutat. Res. 90, 91-109 (1981), No information
Genetic toxicity in vitro, IUC4#51/Ch.5.5
Baer RL and Rosenthal STA (1972) Induction of|cross-tolerance for contact sensitivity by a non-immunologic|chemical. Feeding dichloronitrobenzene induces tolerance to|dinitrochlorobenzene. J Immunol 108: 706 - 710
Method: other: according to Maguire HC & Chase MW (1967) J Invest Dermatol 49, 460, see also freetext TC
Bal'yan VV, Petrosyan FR, Gizhlaryan MS (1983). Embryotoxic effect of 1,4-dichloro-2-butene in inhalation administration. Zh. Eksp. Klin. Med. 23, 118-121.
Developmental toxicity / teratogenicity, IUC4#2/Ch.5.8.2
Lindenschmidt, R.C. et al. (1986): Toxicology 38, 151 - 160
Olivier, P., Marzin, D. (1987). Study of the genotoxic|potential of 48 inorganic derivates with the SOS chromotest.|Mutation Res. 189:263-269.
BASF AG, Safety Data Sheet, METHYLHEPTENONE, 15.11.2001
Pyatnitzkaya LW et al. (1973): Toxicological Properties of|beta-naphthol during its chronic action. Gig Trud |Prof Zabol 6, 54-55 (in Russian)
Repeated dose toxicity: dermal, IUC4#11/Ch.5.4
diammonium 2,2'-dithiodiacetate (IUC4 DSN 3319)
Mead C and McKenzie J (2005) Diammonium dithioglycolate: Algal inhibition test. SPL Project No. 1158/049 (Bruno Bock Chemische Fabrik GmbH & Co KG unpublished study).
3-aminopropyldimethylamine (IUC4 DSN 66)
dos Santos, M.A. (2001) Menthol-Induced Asthma: A Case|Report, J. Investig. Allergol. Clin. Immunol. 11(1), 56-58
Ekman B, Stroembeck JP (1947) Demonstration of tumorigenic|decomposition products of 2,3-azotoluene. Acta Physiol Scand|14: 43-50
Repeated dose toxicity: oral, IUC4#6/Ch.5.4
Phys.-chem.Daten aus CRC Handbook of Chemistry and Physics, 70th ed. 1989-1990
Mullaney, T. 2004. Tetrabutyltin: Acute Oral Toxicity in the Rat - Acute Toxic Class Method. SafePharm Laboratories, Derbyshire, U.K. SPL Project Number: 445/450.
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
BASF AG (1988). Department of Analytical Chemistry, report|J.No. 127044/01, 01 Aug 1988 (unpublished).
Method: other (measured): following OECD 107
Bringmann,G., Kuehn,R., Vom Wasser 50, 45-60, 1978, No information
Method: other: Static Cell Multiplication Inhibition Test
Nippon Soda Co., LTD. (1973), unpublished report
Acute toxicity: inhalation, IUC4#9/Ch.5.1.2
Bacteria strain: Salmonella typhimurium strains TA 1535, TA 1537, TA 1538, TA 98, TA 100.|Yeast strains: Saccharomyces cerevisiae, strain D4
Kao,A.S., Air & Waste 44, 683-696, 1994, No information
Phototransformation in air, IUC4#9/Ch.3.1.1
Clark B., Chamblee T., Iacobucci G., 1989, Micellar-induced selectivity and rate enhancement in the acid-catalyzed cyclization and rearrangement of monterpenes. The solvolysis of linalyl and geranyl acetates, J. Org. Chem. 54 (5):1032-1036
Hexabromocyclododecane (HBCDD)_3194-55-6
Pereira, M.A. et al.: Environ. Mutagen. 4, 317 (1982);|abstract Ad-9, No information
Method: other: in vivo chromosomal aberrations - mammals (somatic cells)
Genetic toxicity in vivo, IUC4#59/Ch.5.6
BASF AG, unpublished calculation, EPISUITE, Level III Fugacity Model, 2002
Biodegradation in soil, IUC4#10/Ch.3.1.3
Bayer Industry Services (2004a). Vapor Pressure of 1,4-Dichloro-2-Butene. Unpublished Report, No. 04/010/01.
Randstroem, S.: Acta. Patholog. et Microbiolog. Scand. 111,|113-114 (1955);|cited in: Bruehl, E.M. and Einbrodt, H.J.; Wissenschaft und| Umwelt 3/1987, 167-170 (1987), No information
Developmental toxicity / teratogenicity, IUC4#20/Ch.5.8.2
Short-term toxicity to fish, IUC4#45/Ch.4.1
Smyth, H. F. Seaton J., and Fischer L. (1941).|The single dose toxicity of some glycols and derivatives.|J. Ind. Hyg. Toxicol. 23, 259-268, No information
Kakiichi,N. et al., J. Antibact. Antifung. Agents 23(11),|669-673, 1995, No information
Toxicity to microorganisms, IUC4#16/Ch.4.4
Martin FL, Cole KJ, Orme MH, Grover PL, Phillips DH, Venitt|S (1999) The DNA repair inhibitors hydroxyurea and cytosine|arabinoside enhance the sensitivity of the alkaline|single-cell gel electrophoresis (comet) assay in|metabolically-competent MCL-5 cells. Mut Res 445: 21-43
Method: other: alkaline single-cell gel electrophoresis (comet) assay according to Singh et al.,1988, Exp. Cell Res. 175, 184-191
Genetic toxicity in vitro, IUC4#115/Ch.5.5
Rat Oral Subchronic Toxicity Study of Normal Butanol|Toxicity Research Laboratories, Ltd. Muskegon, MI. TRL Study|#032-006 dated 1986.
Repeated dose toxicity: oral, IUC4#30/Ch.5.4
M&T Chemicals Inc., TSCAT, OTS0200247, Doc I.D. 8EHQ-1177-0015, 04 August 1978
Huls America (1991) Silicon Compounds: Register and Review,|5th. Ed. Huls America, Piscataway, NJ.
RCC Ltd. (2005) Determination of the Vapour Pressure of|3-mercaptopropanoic acid methyl ester (MMP). RCC Study|Number 858401. April 19, 2005.
OECD Guideline 104 (Vapour Pressure Curve)
Lewis RJ (1993). Hawley´s Condensed Chemical Dictionary. 12th ed. Van Nostrand Reinhold Company, New York, p. 379.
Rampy LW (1973) Product Safety Testing NBS-034. Unpublished|Dow report.
BASF AG (1971). Department of Toxicology, IRT rat, unpublished study, Study No. XXI/183, 22 December 1971.
Method: other: in accordance with Smyth, H.F. and Carpenter, C.P.: J. Ind. Hyg. Toxicol., 26, 269, 1944
RTECS, update 8912: Gig. Truda i Prof. Zabol. 31(12), 53|(1987)
SEHSC (2009) Personal Communication between T Hill, SEHSC|Scientific Programs Manager and SEHSC members (Clariant LSM,|Evonik, Dow Corning Corporation, Momentive, Bluestar|Silicones, Shin-Etsu Silicones of America and Wacker|Chemical Corporation)
Mitsuboshi Chemical Co., Ltd.: unpublished report
Mount, D.R., Gulley, D.D., Hockett, J.R., Garrison, T.D.,|Evans, J.M. (1997). Statistical models to predict the|toxicity of major ions to Ceriodaphnia dubia, Dpahnia magna|and Pimephales promelas (fathead minnows). Environmental|Toxicology and Chemistry 16(10):2009-2019.
Kitaeva, L.V. and Shvartsman, P.Y.: Gig. Sanit. 5, 75-76|(1988), No information
Genetic toxicity in vivo, IUC4#54/Ch.5.6
EPA, Chemical Hazard Information Profile, Draft Report,|4-Chloronitrobenzene (1983)
Short-term toxicity to aquatic invertebrates, IUC4#7/Ch.4.2
Method: other: according to German National Standard DIN 38412, part 8
Kirk-Othmer Encyclopedia of Chemical Technology (1982) 3rd|ed., Volumes 1-26. New York, NY: John Wiley and Sons,|1978-1984., p. V20 896 (1982)
Teresa M.V.M. et al. (2003): Effect of sodium metabisulphite|on germination, growth and yield of Vigna sinensis, Savi. J.|Environ. Biol. 24(4), 449-452
Toxicity to terrestrial plants, IUC4#40/Ch.4.6.2
BASF AG (2003), Department of Product Safety, unpublished|report, Test on the volatility in an algae, daphnia and fish|test, project no. 00/0274-2, 23 May 2003
Monsanto Study IR-79-263 as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Repeated dose toxicity: dermal, IUC4#80/Ch.5.4
BASF Corp. Internal Toxicology Report dated 9/10/91
Ministry of Health, Labour and Welfare(MHLW), Japan.(2003),|571-605
OECD Guideline 401 (Acute Oral Toxicity)
Monsanto study MO-77-615B. Biodegradation of Phosphate Esters. (1977)
Walsh, G.E., L.L. McLaughlan, E.M. Lores, M.K. Louie, and C.H. Deans. 1985. Effects of organotins on growth and survival of two marine diatoms, Skeletonema costatum and Thalassiosira pseudonana. Chemosphere. 14(3/4):383-392.
Toxicity to aquatic algae and cyanobacteria, IUC4#4/Ch.4.3
Dave, G. et al., Toxicity of 8 Solvent Extraction Chemicals|and of Cadium to Water Fleas, Daphnia Magna, Rainbow Trout,|Salmo Gairdneri, amd Zebrafish, Brachydanio Rerio. Comp.Biochem. Physiol. 69C (1), 83-98 (1981)
Short-term toxicity to aquatic invertebrates, IUC4#40/Ch.4.2
National Institute of Environmental Research (NIER), 2002. Calcium sulfate dihydrate: Skin sensitisation study in Guinea pigs (Test No. BO2113), Tested by Biotoxtech, Korea
Clary JJ (1977). Toxicity of chloroprene, 1,3-dichlorobutene-2, and 1,4-dichlorobutene-2. Environm. Health Perspect 21, 269-274.
Method: other: 6 animals/group tested; 3/6 sacrificed 1 day after the last exposure, 3/6 after an additional 14 d-recovery period; chamber atmosphere was examined in 1 h-intervals
primary liver cell cultures from adult male Sprague-Dawley rats
BASF AG (2007). Safety data sheet according to 91/155/EEC.|FORMIC ACID 99-100%, last update 27 Feb 2007.
Appearance/physical state/colour, IUC4#6/Ch.1.1.1
Method: other: Letale Wirkung beim Zebrabaerbling, UBA-Verfahrensvorschlag, Mai 1984, Letale Wirkung beim Zebrabaerbling Brachydanio rerio LC0, LC50, LC100, 48-96h
3-aminopropyltriethoxysilane (IUC4 DSN 46)
BASF (1964) Acute toxicity in rats (XIV/182-184). BASF AG,|Department of Toxicology, 22.09.1964 (unpublished data)
Method: other: Determination of the approximative median lethal dose
Eastman Kodak (1954). Toxicity report. In: TSCATS|Doc#86-920000008: Letter from Eastman Kodak Company|to USEPA submitting enclosed Toxicity & Health Hazard|Summary, Material Safety Data Sheet & Toxicity Reports on|3-hydroxy-2-naphthoic acid, 01 Oct 1991
BASF AG, Toxicology Research Department, study report dated|04.08.75 (1975)
6,10-dimethylundeca-3,5,9-trien-2-one (IUC4 DSN 60)
Tonogai Y and Ito Y (1984). Toxicity of organic nitrogen|compounds on fish - Syncopic effect of aniline derivatives|on fish. Seitai Kagaku 7 (1), 17-26.
Franke J. (2008) Hexamethyldisilazane (CAS No. 999-97-3)|Determination of the Freezing Point / Freezing Range. Harlan|Laboratories Study Number C07845. November 18, 2008
EU Method A.1 (Melting / Freezing Temperature)
Bioreliance. 2001. Mammalian erythrocyte micronucleus test.|Study No. AA41MJ.123.BTL for BP Amoco.
Schafer,E.W.et al Toxicol. Appl. Pharmacol. 1972, 21, 315.
de Groot, W.A. and Groeneveld, A.H.C. (1998) The acute|toxicity of sodium chloride and calcium chloride to Daphnia|magna. Solvay Pharmaceuticals Study No. C.SOL.51.112/Int.|Doc. No. 56834/45/98.
Short-term toxicity to aquatic invertebrates, IUC4#10/Ch.4.2
THOR database Pomona 89, MedChem Software 1989. Daylight,|Chemical Information Systems, Claremont, CA 91711, USA
BASF AG, 2003, Department of Product Safety, Laboratory of|Ecology, Hemmung der Algenzellvermehrung nach DIN 38412 L9:|"78% choline chloride dissolved in water", unpublished data,||reprint of report No. 09908 (06 Nov 1989), 16 Sept 2003
Method: other: according to DIN 38412 Part 9
BIA, Berufsgenossenschaftliches Institut für Arbeits-|sicherheit, GESTIS-Database (2nd Edition), Hauptverband der|gewerblichen Berufsgenossenschaften (HVBG) (Editor), Sankt|Augustin, 04.01.2002
Salmonella typhimurium TA98, TA100, TA1535, TA1537
IARC Monographs on the Evaluation of Carcinogenic Risks to|Humans, Vol. 62: "Wood dust and formaldehyde", Lyon (1995),|pp. 217-365, No information
Kuehn, R. und Birett, K., Merkblaetter gefaehrliche|Arbeitsstoffe, Ecomed-Verlagsgesellschaft, MB-Nr. N 051|(6/80)
Andrews JE, Ebron-McCoy M, Kavlock RJ, and Rogers JM (1993).|Lowering pH increases embryonic sensitivity to formate in|whole embryo culture. Toxicology In Vitro 7, 757-62.
Developmental toxicity / teratogenicity, IUC4#3/Ch.5.8.2
Liu J, Lang P (2000) Effect of monotoxicity and mixtoxicity|of nitroaromatics to the green algae, Scenedesmus obliquus.|J Environ Sci 12 (3): 367 - 368
Method: other: OECD Guide-line 201 (1981) and OJEC (1983)
Toxicity to aquatic algae and cyanobacteria, IUC4#90/Ch.4.3
RL 4 cells (epithelial-like cells from rat liver)
Marzulli, F.N. and Maguire, H.C.: Fd. Chem. Toxicol. 20,|67-74 (1982), No information
Suter W and Jaeger I (1982): Comparative evaluation of|different pairs of DNA repair-deficient and DNA|repair-proficient bacterial tester strains for rapid|detection of chemical mutagens and carcinogens. Mutation|Research 97, 1-18
Smyth HF et al. (1962) Amer Ind Hyg Assoc J, 23, 95-107.
BASF AG (1982). Internal Report: Acute toxicity of|o-toluidine to Leuciscus idus. (Internal substance no.|82/31).
Method: E03-05:DIN-Standard 38412 Part 15 (Fish, Acute toxicity test), Method of the German Standards Institution, Berlin, Germany
Donovan, S.M. et al.: Environ. Mutagen. 5, 476 (1983);|abstract Ee-19, No information
Ishidate, M. jr.: Chromosomal Aberration Test in vitro,|Realize Inc. (1977); p. 90
Chapin RE and Sloane RA (1997) Environ Health Perspect, 105 (Suppl 1), 233-234.
Paschin YV, Bakhitova LM, Benthen TI (1986) Increased antimutagenic activity of simple substituted phenols mixed with hindered phenolic antioxidant dibunol. Food and Chemical Toxicology 24(8):881-883.
Environmental Agency, Japan:(1998) unpublished report on|Daphnia sp., Acute Immobilisation Test and Reproduction Test|(No. 91907)
TSCAT, OTS0537575, Doc 88-920004594; 04 Aug 1992, with cover letter from Union Carbide Co. to EPA dated 28 Jul 1992, attached report no. 5670-89 from BioDynamics Inc., dated 11 Jul 1990; Sponsor: Union Carbide Co., USA.
BASF AG (1980). TUU/W 3, report No. 78/306 (unpublished).
Biodegradation in water: screening tests, IUC4#5/Ch.3.6
CIT (2003) Study number 24552. Water solubility of IOTG. May|22, 2003.
INBIFO (1974). 3-Month toxicity study with laurolactam and|caprolactam (reference substance) on beagles, oral|application. Report No. A 0405/1042 (unpublished)
Centre de Recherche et d'Elevage des Oncins (1975). Essais|de toxicité et de tolérance cutanée du produit Lactame 12|(Lauryl lactame, Report IC-DREB-R 751036 (unpublished)
Method: other: similar to OECD TG 405 (1981), for details see Test conditions
Method: other: 10 rats/sex/dose group, reproductive system evaluation
Toxicity to reproduction, IUC4#5/Ch.5.8.1
Rumyanstev A.P., Lobanova I.YA., Tiunova L.V. and Chernikova|V.V. Toxicology of Butyl Alcohol. Khim. Prom.-st. Ser.|Toksikol. Sanit. Khim. Plastmass. 2:24-26. 1979.
"An inhalation two-generation reproductive toxicity study of isobutanol in rats." WIL Research Laboratory Study Number WIL-186013, WIL Research Laboratories, Inc., 1407 George Rd, Ashland, OH 44805-9281, sponsored by the Oxo-Process Panel of the American Chemistry Council, 1300 Wilson Boulevard, Arlington VA 22209.2003
reproductive output, mortality, body length
APCI, Dabco Crystal Toxicity And Irritation Studies,|unpublished studies, APCI RRRS EXT-90/008, 14 Oct 1974
BASF AG (1989). Department of Analytical Chemistry, report|BRU 89.065, 10 Mar 1989 (unpublished).
Method: other (measured): test procedure according to an internal BASF standard, comparable to OECD Guideline No. 104
Patterson JW and Kodukala PS (1981). Biodegradation of|hazardous organic pollutants. Chem. Eng. Progr. 77, 48-55.
Biodegradation in water: screening tests, IUC4#110/Ch.3.5
Robinson,D.J.S., Perkins,E.J., Cumbria Sea Fish. Comm., Sci.|Rep. No.74/1, The Courts, Carlisle, England, 22 p., (1977),|zitiert nach AQUIRE (12/92)
Short-term toxicity to aquatic invertebrates, IUC4#70/Ch.4.2
Windholz (1983): The Merck Index, 10th ed. Rahway, NJ, Merck|& Co., Inc., 1381-1382
Bayer AG (2002b) Abiotic degradation of|4-Aminodiphenylamine. GLP Final Report. Unpublished study|(2002-09-19)
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
Material Safety Data Sheet of 4-ethyl morpholine (2004).|Nippon Nyukazai Co., Ltd.
Chemfinder Internet Database (2003). Data sheet for tungsten|carbide. http://chemfinder.cambridgesoft.com.
Adema,D.M.M., van den Bos Bakker,G.H., TNO-report|(No.R 86/326a), 6-13, (1986)
Short-term toxicity to aquatic invertebrates, IUC4#4/Ch.4.2
Bayer AG 1986f, Internal study: Life Cycle-Test with Daphnia|magna according to OECD 202 of 1984 (1986)
Method: other: OECD Guideline 202, part 2 (1984)
Long-term toxicity to aquatic invertebrates, IUC4#1/Ch.4.5.2
Allied Corporation (1994) Acute eye irritation study of|vinyl oximino silane (VOS). Internal study. Allied|Corporation Department of Toxicology, Morristown NJ. March|9, 1984
Method: other: CFR Title 16: Subchapter C- Federal Hazardous Substances Act, Part 1500.42, Revised Jan 1, 1978
Koenemann H (1981). Quantitative structure-activity relationships in fish toxicity studies. Part 1: Relationship for 50 industrial pollutants. Toxicology 19 (3), 209-221.
Method: other (calculated): Method of Rekker RF (1977). The Hydrophobic Fragmental Constant, Elsevier, Amsterdam was used.
Noack U (1995a). Laboratorium für angewandte Biologie. Fish,|acute toxicity test, 96 h (Zebra fish) of tungsten carbide|(WC) HCST product designation WC DS 100. Study-No. FAZ42411.
Short-term toxicity to fish, IUC4#10/Ch.4.1
GENERAL ELECTRIC (1981) PRIMARY EYE IRRITATION STUDY IN|RABBITS OF X-39381 DISILAZANE; 10/22/81, EPA 86940001698,|Fiche No. OTS0557979; Submitted by Industry
Ewell WS, Gorsuch JW, Kringle RO, Robillard KA, Spiegel RC (1986) Simultaneous evaluation of the acute effects of chemicals on seven aquatic species. Environmental Toxicology and Chemistry 5:831-840.
Hüls America Inc. (1990). 4-Hour acute inhalation toxicity study with 3-isocyanatomethyl-3,5,5-trimethylcyclohexylisocyanate in rats with cover letter. NTIS/OTS Microfiche 0530239, Doc 86-910000493.
Method: other: OECD Guideline 403 (1981)
Vickers (1975) Texaco (Jefferson) Chemical Company, Austin|Research Laboratory, Texas, USA 30/10/75.
Huels-Bericht Nr. AW 172. 1988. (unveroeffentlicht) cited in: IUCLID (1995) data sheet for n-butyl acetate
Algenwachstums-Hemmtest nach UBA 1984 (Vergahrensvorschlag Stand Februar 1984)
Toxicity to aquatic algae and cyanobacteria.001
Campiglio, R. et al. (1984), ASPETTI DELLA PATOLOGIA|ALLERGICA NELL'INDUSTRIA COSMETICA, Med. Lav. 75, 407-411
Environmental Health Bureau, The Japanese Ministry of Health|and Welfare: Report on one-generation reproduction toxicity|study of 2-hydroxy-3-naphthoic acid by oral administration|in rats. Hatano Research Institute, Food and Drug Safety|Centre, HRI Report No. 10-1636. Sep 4, 2000.
OECD Guideline 415 (One-Generation Reproduction Toxicity Study)
Lu G-H, Yuan X, Zhao Y-H (2001) QSAR Study on the Toxicity|of Substituted Benzenes to the Algae (Scenedesmus obliquus).|Chemosphere 44: 437 - 440
Method: other: OECD Guideline 201 (Algae, Growth inhibition test, 1981)
Toxicity to aquatic algae and cyanobacteria, IUC4#120/Ch.4.3
BASF AG: Department of Toxicology, unpublished study, Report on the study of the primary irritation to the intact skin of rabbits, (XII/248), October 04, 1962
CERI (2004). Vapour pressure study of Tetrahydrofurfuryl|alcohol: CAS No. 97-99-4. Test Number 805283. Unpublished|data.
Koiwa, Igatashi. (1979): Toyo Soda Kenkyu Hokoku 23, 35-39;|cited in: Chem. Abstr. 90, 182922r (1979)
Biodegradation in water: screening tests, IUC4#34/Ch.3.5
HSDB. Hazardous Substances Data Bank. National Library of|Medicine (1998).
Method: E12-06:Cell multiplication inhibition test
Repeated dose toxicity: inhalation, IUC4#17/Ch.5.4
Solvay (1992), "Chlorure d'allyle", Material Safety Data|Sheet, No. 79, Jul.
USEPA. 2000. PCKOCWIN, Version 1.66. Soil Adsorption Coefficient. EPIWIN (Estimation Program Interface for Windows). Version 3.12. Office of Pollution Prevention Toxics (OPPTS) and Syracuse Research Corporation.
Method: other (calculation): PCKOCWIN v1.66
Adsorption / desorption, IUC4#1/Ch.3.3.2
Zwart, A. et al.: Toxicology 51, 87-99 (1988), No information
Method: other: cell proliferation measurement
Repeated dose toxicity: inhalation, IUC4#54/Ch.5.4
Elf Atochem S.A. (1998) Isooctyl thioglycolate: Acute|toxicity to daphnia. Centre d'application de Levallois. |Etude n° 4177/95/B
Gage, J. C. (1970) Brit. J. Indust. Med.27, 1-18
Repeated dose toxicity: inhalation, IUC4#30/Ch.5.4
CERI (1999). Report No. 91534. Test on acute toxicity to|Oryzias latipes. Chemicals Evaluation and Research Institute|of Japan.
Engelhardt, D., and Hoffmann, H.D. Cytogenetic Study In Vivo|with n-butanol in the Mouse Micronucleus Test - Single Oral|Administration. (1998) Project No. 26M0346/974126,|Department of Toxicology, BASF Aktiengesellschaft, D-67056|Ludwigshafen/Rhein, FRG.
Genetic toxicity in vivo, IUC4#10/Ch.5.6
OECD Guideline 211 (Daphnia magna Reproduction Test)
Boettcher J, Popovic J (1992) TINOPAL DMS-Z: Report on the|acute toxicity (96h) to zebrafish. CIBA-GEIGY Ltd., CH-4002|Basel (Switzerland)
Cervinka O, Dudek V, Stihel Z, Zikmund J (1979). Optically|active heptamethylenecarbodiimide. Collect. Czech. Chem.|Commun. 44, 2843-2845
Maxwell, W.A. and Newell, G.W. (1974): Screening techniques|for environmental mutagens. In: Molecular and Environmental|Aspects of Mutagenesis (Prakash, L., Sherman, F., Lawrence,|C.W. & Taber, H.W., eds.), Charles C. Thomas Publisher,|Springfield, Illinois/USA; Chapter 14, pages 223-252
Genetic toxicity in vivo, IUC4#71/Ch.5.6
OECD TG 478 Genetic Toxicology: Rodent Dominant Lethal Test
Munro, N.B., Talmage, S.S., Griffin, G.D., Waters, L.C.,|Watson, A.P., King, J.F., Hauschild, V.: The source, fate,|and toxicity of chemical warfare agent degradation products.|Environ. Health Perspect. 107, 933-974 (1999)
Adsorption / desorption, IUC4#4/Ch.3.3.2
Lien E., et al. Dipolarity and Partition Coefficient of|Solvents, Drugs and Chemicals, Quant Struct-Act Relat|12:158-163, 1993
Klaine, Ward (1983): Environ. Toxicol. Chem. 2(2), 245-249
Toxicity to aquatic algae and cyanobacteria, IUC4#6/Ch.4.3
Rinehart, WE, Primary Dermal Irritation Study in Rabbits, |Toxicological Resources Unit, Bio/dynamics Inc., 1978.
Hoechst AG (1992): Unveröffentl. Unters. (Ber.-Nr. W88-0063|vom 11.11.1992)
Method: other: Zahn-Wellens-Test, DIN 38412, L25
Biodegradation in water: screening tests, IUC4#10/Ch.3.5
Kligerman AD, Wilmer JL, Erexson GL (1982). Session V:|Cytogenetics and sister chromatid exchange. Banbury Report|13, 277-291
Method: other: according to Kligerman A.D. et al., Environ. Mutagen.3, 531 (1981)
reported in NTP: Technical Report No. TR 343 (1989)
Chemicals Evaluation and Research Institute, Japan
Frank, J.F. (1948) The toxicity of sodium chlorate|herbicides. Can. J. Comp. Med., 12(8), 216-218.
Bayer AG data, Report No. 5800, January 5, 1976
Method: other: ear, dose: 500 mg/animal, undissolved TS, covered by cellulose pads and plaster, a rolled gauze pad was put on it, all together was bandaged, exposure time: 24 h, semi-occlusive, observation time 7 d
ACGIH (American Conference of Governmental Industrial Hygienists) (2004). TLVs and BEIs, Threshold Limit Values for Chemical Substances and Physical Agents, Biological Exposure Indices. Isophorone diisocyanate (2 pp). Cincinnati (OH, USA).
Unpublished Report (1992) Ames Salmonella Microsome, unpublished report number 91/AKL148/1163 January 28, 1992, as conducted by LSR |(Delamine).
OECD Guideline 471 (Bacterial Reverse Mutation Assay)
Patty's Industrial Hygiene and Toxicology (1994) 4th edition, Vol IID, John Wiley & Sons, New York (USA).
Repeated dose toxicity: oral, IUC4#90/Ch.5.4
Hayashi, M., Kishi, M., Sofuni, T. and Ishidate Jr., M|(1988): Micronucleus tests in mice on 39 food additives and|eight miscellaneous chemicals. Fd Chem Toxic, 26, 487-500.
Method: other: similar to OECD Guide-line 474
Chemical Inspection and Testing Institute, Japan (1999):|report on physical and chemical properties
CERI (2004). Partition Coefficient study of|Tetrahydrofurfuryl alcohol: CAS No. 97-99-4. Test Number|80528x. Unpublished data.
Krasavage WJ, Vlaovic MS. 1982. Comparative toxicity of nine glycol ethers: III. Six weeks repeated dose study. Eastman Kodak Company, Health Safety and Human Factors Laboratory, Report dated March 15, 1982.
Kimber, I. et al.: Toxicol. Lett. 55, 203-213 (1991), No information
Monarca S, Rizzi R, Pasquini R, Pool BL, De-Fusco R, |Biscardi D, Gervasoni M, Piatti E. (1989) Studies on|genotoxic properties of precursors of polyethylene|terephthalate plastics. Mutat Res 216, 314-315
Chemical Carcinogenesis Research Information System |(CCRIS) (1991) Record 2456. (http://toxnet.nlm.nih.|gov/cgi-bin/sis/search/r?dbs+ccris:@term+@rn+999-97-3)
Method: other: comparable to OECD TG 476
Drake, J.C. 1973. Geigy Pharamceuticals. Eye Irritation Test in Albino Rabbits with Compound TK 11339. 31.1.1973.
Method: other: U.S. Federal Hazardous Substances Labelling Act, Section 191.12
Rush, R.E. 1993. An acute dermal toxicity study in rabbits with [Mono/Di] methyltin chlorides solution. Springborn Laboratories, Inc. SLS Study No. 3255.11. July 26, 1993.
OECD Guideline 402 (Acute Dermal Toxicity)
Ward, T.J., J.P. Magazu, and R.L. Boeri. 1996. Acute toxicity of mixed methyltin chlorides to the fathead minnow, Pimephales promelas. T.R. Wilbury Laboratories, Inc. Study Number 855-MO. January 4, 1996.
Fregert, S., Tegner, E., Contact Dermatitis News Lett., 9,|200 (1971)
Ryan, B.M. 1988. Teratological evaluation of trimellitic|anhydride (TMA) in rats and guinea pigs. Submitted in|partial fulfilment of the requirements for the degree of|Master of Science in Biology in the School of Advanced|Studies of Illinois Institute of Technology, Chicago,|Illinois.
Atkinson,R., J. Phys. Chem. Ref. Data, Monograph 1, 130,|1989, No information
BASF AG, Department of product safety, unpublished|calculations (2002)
BASF (1989): Study of the acute toxicity of Kaliumsulfit to|Golden orfe. BASF AG, Department of Toxicology, Proj. No.|10F0640/885042, Jun 29, 1989
Method: other: DIN 38 412 Testverfahren mit Wasserorganismen (Gruppe L)
Morton International, Inc. 1996. Ames/Salmonella-E. coli Reverse Mutation Assay on Test Article 1706-152, Dimethyltin bis(2-ethylhexylthioglycolate). Study performed by Pharmakon USA. Study Number 0301EM01.001.
Method: other: comparable to guidelines established by OECD, USEPA, and USFDA
Tokyo Metropolitan Research Laboratory of Public Health|(1978): |In: Shell Oil Co. (1992): NTIS/OTS 0535892
Genetic toxicity in vivo, IUC4#37/Ch.5.6
Marhold, J. (1986) Prehled Prumyslove Toxikol. Org. Latky,|459-460.
Reported in AIDA (13/11/92)-ALSTOFF INFORMATION Date Bank |and in Kennedy G.L. (1986). CRC Crit. Rev. Toxicol.,|17:129-182 from Monsanto Co. - Unpublished Data: teratogenic|study, rabbits.
Procter & Gamble Co.(1992a) Up & Down procedure for estimating acute oral toxicity (LD50) of benzoic acid in rats. Hazleton Laboratories America, Inc. U.S.EPA/OPTS Public Files, Doc.I.D.88-920004921, OTS0542098.
Toze S and Zappia L (1999). Microbial degradation of|munition compounds in production wasterwater. Wat Res 33|(13), 3040 - 3045.
Method: other: Batch degradation experiments in aquatic microcosms
Biodegradation in water: screening tests, IUC4#37/Ch.3.5
Budavari, S. (ed.), The Merck Index, 11th ed. Rahway, Merck|& Co. 248 (1989)
Thyssen (1976). Bestimmung der akuten Toxizität (LD50), Substanz 3-Isocyanatomethyl-3,5,5-trimethylcyclohexylisocyanat (IPDI). Bayer AG short report, July 23, 1976 (unpublished).
Genetic toxicity in vitro, IUC4#70/Ch.5.5
Union Carbide Corp. (1968). Formic acid data sheet. Cited|in:|RTECS (2006). Register of Toxic Effects of Chemical|Substances, Update 200602.
Nixon GA, Tyson CA, Wertz WC (1975). Interspecies comparison|of skin irritancy. Toxicol. Applied Pharmacol., 31, 481-490.
Method: other: revised FHSA procedure proposed by FDA (1972)
Florin, I., Rutberg, L., Curvall, M. and C.R. Enzell, 1979,|Screening of tobacco smoke constituents for mutagenicity|using the Ames' Test, Toxicology, 15, 219-232, 1979
Method: other: nach Ames et al.: Mut. Res., 31, 347, 1975
Method: other: according to Anderson et al. (1948)
Short-term toxicity to aquatic invertebrates, IUC4#5/Ch.4.2
Ballantyne B, Myers RC. 1987. The comparative acute toxicity|and primary irritancy of the monohexyl ethers of ethylene|and diethylene glycol. Vet Human Tox 29:361-366.
Hüls AG (1992a). Bestimmung der biologischen Abbaubarkeit|von Vestamin IPD im mod. Coupled Units test. Report No.|MCU-10 (unpublished).
Method: other: OECD Guide-line 303 A (1981), modified according to DIN 38412, part 26
Biodynamic Inc., Project No. 89-3535, January 24 (1991)|(at the request of the Synthetic Organic Chemical Manu-|facturers Association Inc.)
Developmental toxicity / teratogenicity, IUC4#60/Ch.5.8.2
in vivo mammalian erythrocyte micronucleus study
TGD, 2003. Technical Guidance Document on Risk Assessment in|support of Commission Directive 93/67/EEC on risk assessment|of new notified substances, Commission Regulation (EC) No|1488/94 on risk assessment for existing substances and|Directive 98/8/EC of the European Parliament and of the|Council concerning the placing of biocidal products on the|market. Part III. European Commission Joint Research Centre.|EUR 20418 EN/3.
Method: other: calculated according to TGD (2003)
Bioaccumulation: aquatic / sediment, IUC4#3/Ch.3.7
Horger L.M. & Gerheim E.B. (1958). Proc. Soc. Exp. Biol. Med. 97 , 444.
Short-term toxicity to aquatic invertebrates, IUC4#6/Ch.4.2
Nagao M, Takahashi Y (1981) Mutagenic Activity of 42 Coded|Compounds in the Salmonella/Microsome Assay. Prog Mut Res 1:|302-313
Method: other: according to Ames et al., Mutat. Res. 31, 347 (1975) : preincubation methodology, solvent control, no positive control
Genetic toxicity in vitro, IUC4#33/Ch.5.5
He Y, Yang X, Zhong X, Deng L, Zhang J (1989). Approach to|long-term effects of phosphorus trichloride. Weisheng|Dulixue Zazhi 3, 37-40.
Arkhipova OG, Kochetova TA, Shinkarenko BN (1963) Toxic|properties and biotransformation of benzotrichloride. Gig|Sanit 28: 30 - 34
Method: other: shaved skin, 1ml/painting, 3 paintings/w
NTP (1995).|(http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=|npsearch.ntpstudiesforchemical&cas_no=107%2D18%2D6)
Lewis, R.J. Sr (Ed.): Hawley's Condensed Chemical|Dictionary. 12th ed. New York, NY: Van Nostrand Rheinhold|Co., 385(1993)
Appearance/physical state/colour, IUC4#2/Ch.1.1.1
Takahashi, O. et al., Food Cosmet. Toxicol. 18, 229-235|(1980)
Repeated dose toxicity: oral, IUC4#24/Ch.5.4
Allied Corporation. Analysis of Sister Chromatid Exchange|(SCE) Frequencies in|Peripheral Lymphocytes of Rabbits Exposed Subacutely to|[3-Glycidoxypropyltrimethoxysilane] (Allied Corporation|Report No. MA-168-81-9; Dow Corning Corporation internal|report number 1999-I0000-46219).
Genetic toxicity in vitro, IUC4#23/Ch.5.5
Bayer AG (1994) Berechnung des Dampfdruckes bei 25 °C für|6PPD (unpublished report)
RCC Research & Consulting Company Ltd. (1988). 3-Isocyanatomethyl-3.5.5-trimethylcyclohexylisocyanat - 4-hour acute inhalation toxicity study in rats. Report No. 094320 (Hüls AG, unpublished).
Method: other: OECD Guideline 403 (1981) and Sachsse et al. (1973, 1976)
Acute toxicity: inhalation, IUC4#4/Ch.5.1.2
Scheman, A.J., et al., Contact Dermatitis, 38, 332-336|(1998)
S. typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538
Schering AG. 1993. Study on the biodegradability of Di-n-butyltin dichloride in the modified Sturm Test. No. IC 4/92. Berlin, Germany. 29.04.1993.
OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
Tatara, C.P., Newman, M.C., McCloskey, J.T. and Williams,|P.L. (1997) Predicting relative metal toxicity with ion|characteristics: Caenorhabditis elegans LC50. Aqua.|Toxicol., 39, 279-290.
Short-term toxicity to aquatic invertebrates, IUC4#90/Ch.4.2
Hoechst AG (1992): Unpublished study. Betanaphthol. Testing|for sensitising properties in the Pirbright-White guinea pig|in the maximisation test. Report no. 92.0345, 19 May 1992
Bayer AG (1976). Internal Study: Toxicity of o-toluidine to|Escherichia coli and to Pseudomonas fluorescens.
Method: other: DIN-Standard 38412 Part 8 (Cell multiplication inhibition test)
BASF (1980) Corrosivity in rabbits (77/164). BASF AG,|Department of Toxicology, 06.05.1980 (unpublished data)
Method: other: in accordance with test guidelines of the US Department of Transportation, Paragraph 173.1200, Federal Register
Greene and Friedman (1979) Short term Mutagenicity and Cell Transformation Screening of Toluene Diamine. V. Chemical Transformation of Secondary Hamster Embryo Cells by Four Toluene Diamine Isomers. Report No. MA-12-77-16 dated May 1979.
Van Duuren B.L. et al, 1979, J. Nat. Canc. Inst., V63, NR6,|P.1423-39.
Stenger, EG et al., (1972) Arzneim. Forsch., 22, 569-574.
BASF AG: Abt. Toxikologie, unveroeffentlichte|Untersuchungen, 26.02.1940
Repeated dose toxicity: inhalation, IUC4#16/Ch.5.4
DeCeaurriz, J.C. et al.: Toxicol. Lett. 9, 137-143 (1981);|cited in: Schaper, M.: Am. Ind. Hyg. assoc. J. 54 (9),| 488-544 (1993), No information
Acute toxicity: inhalation, IUC4#8/Ch.5.1.2
Shimizu M., Yano E. (1986), Mutagenicity of|mono-nitrobenzene derivatives in the Ames test and rec|assay: Mutat. Res. 170, 11-22
Hoechst AG, Report no.492/75: Akute dermale Toxizität von|o-Nitrochlorbenzol an weiblichen SPF-Wistar-Ratten,|1975/oct./01
Method: other: 6 rats/dose, single application to the clipped intact skin, covered by alu and a plaster, exposure time: 24 h, then rinsing, postexposure observation time: 14 d
B. Nandi, 1977, Effect of some volatile aldehydes, ketones,|esters and terpenoids on growth and development of fungi|associated with wheat grains in the field and in storage, J.|Plant Diseas. Protect. 84, 114-128
Toxicity to microorganisms, IUC4#7/Ch.4.4
Foeldesi. 1965. Acta Chim. Acad. Sci. Hung. 45:237-241.
Zimmering S, Mason JM, Valencia R (1989) Chemical|mutagenesis testing in Drosophila. Results of 22 coded|compounds tested in larval feeding experiments. Environ Mol|Mutagen 14: 245-251
Method: other: according Zimmering, Environ. Mutagen. 7, 87 (1985): see also freetext ME
Elmore E, Nelmes AJ (1985) Summary report on the performance|of the inhibition of metabolic cooperation assay. Prog Mut|Res 5: 95-102
Method: other: according Yotti et al., 1979
Genetic toxicity in vitro, IUC4#133/Ch.5.5
Fischer, S.W., Stromberg, P., Bruner, K.A., Boulet, L.D.|(1991). Molluscicidal activity of potassium to the zebra|mussel, Dreissena polymorphia: toxicity and mode of action.|Aquatic Toxicology 20:219-234.
Long, F. (2006) Hydrolysis Rate Constants and Half Lives for|MEKP in Aqueous Solutions; The Industrial Division|Laboratory, Norac Inc, 405 S. Motor Ave, Azusa, CA, USA|11July2006
BASF AG, Department of Toxicology, unpublished data,|(XXV/436), 18 Aug. 1976
ETAD (1999). Turck PA. Prenatal developmental toxicity study|via oral gavage to rats. MPI Research Laboratory Study|Identification No. 795-003 dated 1999-12-02.
Method: other: Guideline OPPTS 870.3700 EPA (1997)
Stom DI, Zubareva LD (1993) Comparative Resistance of Daphnia and Epischura to Toxic Substances in Acute Exposure. Hydrobiological Journal, 30(3): 35-38; Gidrobiol J 29(2):31-34 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Short-term toxicity to aquatic invertebrates, IUC4#14/Ch.4.2
Greene, E. J; A. J. Salerno; M. A. Friedman (1981) Effect of 4 Toluene Diamine Isomers on Murine Testicular DNA Synthesis. Mutation Research, Vol. 91(1): 75-79. (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com)
Clariant GmbH, (1985) Unpublished testing report titled|"o-Chlorbenzylchlorid D, Prufung auf Hautreizung am|Kaninchen", Report No.: 85.0677, 14.07.1985, conducted by|HOECHST AG, Pharma Forschung Toxikologie.
Knacker et al., 1992. A Study of the Acute Immobilisation|to Daphnia of Trimellitic Anhydride. Study Number: |BE-EA-128-91-02-DAK-1.
FMC Corporation, Ammonium persulfate: primary eye irritation|study in rabbits, Study no. I87-0968, 1988.
National Toxicology Program (NTP) (1991) Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344/N Rats and B6C3F1 Mice. (Gavage Studies). Draft TR403.
Genetic toxicity in vivo, IUC4#13/Ch.5.6
Thayer, P.S. et al.: Mutat. Res. 12, 197-203 (1971);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Genetic toxicity in vitro, IUC4#41/Ch.5.5
Dow Corning Corporation (2006) Fate, Distribution, and|Transport of Trimethoxysilane (CAS 2487-90-3) in the|Environment as Predicted by Fugacity Modeling. Dow Corning|Study No: 9786-102
Auergesellschaft (1988). Auer Technikum. Berlin, 12th ed.
Method: other (measured): description of the method is not given
Chemicals Evaluation and Research Institute (2005). 4-Ethyl|morpholine. Calculation of|- Vapour pressure with MPBPWIN v.1.41, 2004|- Log Octanol-Water Partition Coefficient with KOWWIN v.|1.67, 2004|- Indirect Photodegradation with AOPWIN v. 1.91, 2004|- Henry�Ls Law Constant with HENRYWIN v. 3.10, 2004|- Soil Adsorption Coefficient with PCKOCWIN v. 1.66, 2004|- Bioconcentration Factor with BCFWIN v.2.15, 2004|- Water Solbility with WSKOW v1.41, 2004|- Partition Coefficient with KOWWIN v1.67, 2004|- Mackay-Distribution with Level III Fugacity Model, 2004.
Method: other: Estimated value with MPBPWIN v.1.41
BASF AG: Department of Toxicology, unpublished data,|(XII/248), August 14, 1963
EPA (2008). KOWWIN v1.67. Estimation Programs Interface for Microsoft Windows (EPI Suite version 3.20, U.S. Environmental Protection Agency, Office of Pollution Prevention and Toxics, Washington, D.C.).
Method: other (calculated): The partion coefficient was estimated with EPI Suite version 3.20.
Monsanto Company (1992) Initial submission: letter from|Monsanto Co submitting four toxicity studies with|o-chlorobenzyl chloride in rats and rabbits, EPA Doc#|88-920007143, NTIS/OTS0545482.
Method: T09-02:FIFRA Pesticide Assessment Guidelines, Subdivision F, Section 81-2; "Acute Dermal Toxicity Study "TSCA Health Effects Test Guidelines; " Acute Exposure, Dermal Toxicity"
Hahne R. 2002b. Acute Toxicity of the Water Accomodated Fraction (WAF) for 2-Ethylhexyl Acetate to the Water Flea Daphnia magna, Determined under Static Test Conditions. Report #46956 prepared by ABC Laboratories Inc., Columbia Missouri. May 02, 2002.
RCC Ltd, Benzenepropanoic acid,|3,5-bis(1,1-dimethylethyl)-4-hydroxy-, octadecylester:|primary biodegradability in a ready biodegradability test|according to OECD 301, 3 November 2006.
Method: other: primary biodegradability with procedures according to OECD 301
Biodegradation in water: screening tests, IUC4#3/Ch.3.5
Jongerius O., Jongeneelen F., Criteria document for an|occupational exposure limit value of: GLYCEROL, 1992 (4)
Cooney, J.J., L. de Rome, O. Laurence, and G.M. Gadd. 1989. Effects of organotin and organolead conpounds on yeasts. J. Industr. Microbiol. 4:279-288.
Eastman Chemical Company. 2004. Material Safety Data Sheet for "Eastman" DB Acetate
Wester, P.W., Canton, J.H., Dormans, J.A.M.A., 1988.|Pathologicals effects in freshwater fish Poecilia reticulata|(guppy) and Oryzias latipes (medaka) following methyl|bromide and sodium bromide exposure. Aquat. Toxicol.,|12:323-343.
Merck Schuchardt. 1999. Safety Data Sheet. Product No. 808278. Tetra-n-butyltin for synthesis. Date of issue: 08.09.1999.
Hoechst AG, Firmenschrift Aldehyde, Alkohole, Ester,|Acetale/Ether, Business Line Amine/Oxo-Derivate
Lijinsky W and Andrews AW (1980) Mutagenicity of Vinyl|Compounds in Salmonella Typhimurium, Teratogenesis,|Carcinogenesis, and Mutagenesis 1, 259-267
Hallinger, S., Wallnoefer, P. R., Goldbach, H. and Amberger,|A. (1990). Naturwissenschaften. 77, 332-334.
Bisessar, S. & McIlveen, W.D. (1992): Bull. Environ. Contam.|Toxicol. 49, 295-299.
(2-methoxymethylethoxy)propanol (IUC4 DSN 41)
Mellon Institute of Industrial Research (1961). Studies on|Carcinogenesis Completed in 1961. Union Carbide Chemicals Co|Report 24-117.
General Sciences Corporation (1986). Graphical Exposure|Modeling System [Pilotte, J.O. (1982). Fate of Atmospheric|Pollutants]
USEPA. 2000. KOWWIN. Version 1.67. EPIWIN (Estimation Program Interface for Windows). Version 3.11. Office of Pollution Prevention Toxics (OPPTS) and Syracuse Research Corporation.
Method: other (calculated): KOWWIN v1.67
Reported in Du Pont - Haskell Laboratory Internal DMAC|Review, Oct. 1988
Hoechst AG (1987): Unveroeffentlichte Untersuchung|(W 87-211)
Microbiological Associates, Inc. 1991. CHO/HGPRT Mutation|Assay with Confirmation. Laboratory Study Number|T9410.332001.
OECD Guideline 476 (In vitro Mammalian Cell Gene Mutation Test)
Maas-Diepeveen, J.L. and van Leeuwen, C.J., Aquatic toxicity|of aromatic nitro compounds and anilines to several|freshwater species, Report 86-42 (1986)
Short-term toxicity to fish, IUC4#5/Ch.4.1
Monsanto Co. (1978) Final report of several studies on|nitrated orthene with cover letter dated 112191. Younger|Lab. Inc., St. Louis (OTS0534363, 86-920000158)
Bartsch H, Sabadie N, Malaveille C, Camus A-M, Richter-Reichhelm HB (1978). Carcinogen metabolism with human and experimental animal tissues: Inter-individual and species differences. Proc. of 12th Int. Cancer Congr. 1978, Adv. Med. Oncol. Res., 179-187.
Method: other: plate incorporation assay
Szybalski W (1958) Special microbiological systems. II|Observations on chemical mutagenesis in microorganisms. Ann|N Y Acad Sci 76: 475-489
Genetic toxicity in vitro, IUC4#10/Ch.5.5
Zhao Y-H, Wang L-S (1995) Quantitative Structure-Activity|Relationships of Hydrophobic Organic Chemicals. Toxicol|Environ Chem 50: 167 - 172
Method: other: comparable to OECD 202 part 1 (Daphnia: Acute toxicity)
Bhattacharya,S.K., Parkin,G.F., JWPCF 60, 531-536, 1988, No information
Method: other: Anaerobic Degradation Test
CITI (1992). Biodegradtion and Bioaccumulation Data of|Existing Chemicals based on the CSCL Japan, compiled under|the Supervision of Chemical Products Safety Division. Basic|Industries Bureau MITI, CR-No 2-304, 2-47.
Short-term toxicity to fish, IUC4#14/Ch.4.1
TA98, TA100, in part also TA97 and TA1537 plus other, undefined strains
Naas, D.J., 1990. Acute Oral Toxicity Study in Beagle Dogs|with Methyl Bromide. Unpublished report from WIL Research|Laboratories, Inc., Project No. WIL-49006.
BASF AG, department of ecology, unpublished calculation,|30.10.2000
Method: other (calculated): AOP, vers. 1.87
Environment Agency of Japan (1997) unpublished report
Method: other: equivalent ot OECD Guide-line 401
Salmonella typhimurium TA1535, TAl537, TA1538, TA98, TA100
Wiegand H.J. et al.: Non-genotoxicity of acrylic acid and n-butyl acrylate in a mammalian cell system (SHE cells) Arch. Toxicol. 63, 250-251, (1989)i
USEPA. 2000. EPI Suite was developed by EPA's Office of|Pollution, Prevention and Toxics and Syracuse Research|Corporation. The EPI Suite and individual models included|within the software are owned by the U.S. Environmental|Protection Agency and are protected by copyright throughout|the world.
Method: other: calculated using ECOSAR (ver. 0.99g)
Kona K, Nakajima E. (1965) Effect of terephthalic acid on|the vicera of chickens II. Testis, thyroid gland and|auterior lobe of pituitory. Jap Poultry Sci 2(3). 205-209
Repeated dose toxicity: oral, IUC4#15/Ch.5.4
OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
cell density (fluorescence at 685 nm as a size for the biomass)
BASF AG, Labor Ökologie, unveröffentlichte Untersuchung|(1989)
Method: other: respirometric test (BASF-method)
Elf Atochem NA. 1999. Material Safety Data Sheet. Thermolite (R) 108 Stabilizer. Revision 2. Issued 2 August 1999.
Arnold, A.; Goble, F. C.; Cereal Chem., vol. 27, 375 (1950)|in: BIBRA report, Toxicity profile, 1st. ed (1988).
Torkelson et al (1959), Amer. Ind. Hyg. Assoc. J., 20,|217-23.
Method: other: glass-walled chamber of 160 l capacity
Shearer, W.L. (1978) Calcium chloride. In Kirk-Othmer|Encyclopedia of Chemical Technology, 3rd ed., John Wiley &|Sons, New York, Vol. 4, pp. 432-436.
Melting point/freezing point, IUC4#20/Ch.2.1
DuPont, Haskell Laboratory Report No. 96-67, unpublished data
Budavari S (ed) (2001)The Merck Index - An Encyclopedia of|Chemicals, Drugs, and Biologicals. 13th ed.,Merck & Co.,|Inc.,1644
Carpenter, C.P. et al.: Toxicol. Appl. Pharmacol. 28,|313-319 (1974)
Food and Drug Research Laboratoires, Inc. (1974) Teratologic|evaluation of FDA 71-87 (calcium chloride) in mice, rats and|rabbits. Report No. FDABF-GRAS-251. NTIS PB-234 879.
Developmental toxicity / teratogenicity, IUC4#10/Ch.5.8.2
Knie, J. et al., Ergebnisse der Untersuchungen von|chemischen Stoffen mit vier Biotests, Deutsche|Gewässerkundliche Mitteilungen 27 (3), 77-79 (1983)
Method: other: Bewertung toxischer Wasserinhaltsstoffe aus ihrer Inhibitorwirkung auf die Substratoxydation von Pseudomonas Stamm Berlin mit Hilfe polarographischer Sauerstoff-Messungen. Robra, K.H. gwf Wasser/Abwasser 117 (2), 80-86 (1976)
BIBRA: Toxicity Profile Benzyl Alcohol (1989)
Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538
Wright, H.N. Chronic Toxicity Studies of Analgesic and Antipyretic Drugs and Congeners. Tox. & Applied Pharmacology. 11, 280-292, 1967
Quast J.F., Henck,J.W., Dittenber, D.A., McKenna, M.J. (1982), Allyl chloride - acute studies. Results of single 6-hour inhalation exposure studies in laboratory rodents. Report for the Chem. Manuf. Ass. from DOW CHEM (USA), Apr 20.
Method: other: chamber of 14.5 m3 volume; air flow: 2000-3500 l/min
Repeated dose toxicity: inhalation, IUC4#26/Ch.5.4
Salmonella typhimurium strains: TA98, TA100, TA1535, TA1537 and TA1538
Reported by Kennedy G.L. (1986) CRC Crit. Rev. Toxicol.,|17:129-182 from Sherman H., Du Pont, Haskell Laboratory,|Unpublished Data:toxicity study, dieting feeding.
Sergeant EP, Dempsey B (1979) Ionisation Constants of|Organic Acids in Aqueous Solution. International Union of|Pure and Applied Chemistry (IUPAC). IUPAC Chemical Data|Series No. 23. New York, NY. Pergammon Press, Inc. p 43
Barley (Hordeum vulgare) caryopsis and growing root meristematic tips of onion (Allium cepa)
FDRL (1975). Teratological evaluation of FDA 73-78 (KCl) in|mice and rats. Final report prepared under DHEW. Contract|No. FDA 223-74-2176 by Food and Drug Research Laboatories|Inc. Waverly, New York.
Til, H.P. et al.: Fd. Chem. Toxic. 27, 77-87 (1989), No information
Repeated dose toxicity: oral, IUC4#32/Ch.5.4
Koopman, T.S.M. and Pot, T.E. (1986) Primary irritation|study of calcium chloride hexahydrate to the skin of the|male rabbit. Duphar Report No. 56645/32/86.
Skin irritation / corrosion, IUC4#30/Ch.5.2.1
Anderson, E.M. (1991), "Stability of Dicaprolactone and|Caprolactone in Aqueous systems", Bushy Run Research Centre,|report 54-104
E.I. Du Pont de Nemours & Co. / Union Carbide and Carbon|Corp., New York (1983). Isophorone data indicating relative|degree of hazard to animals, NTIS/OTS Microfiche 0205868,|Doc. 878211783.
Cincinnati Milacron Chemicals, Inc. 1978. Extended Acute Oral LD50 Studies of Nine Samples. Ref: 77-1094-21. Study conducted by Hill-Top Toxicology.
Cherkinskii SN, Faidysh EV, Daydova SG (1967) Prom|Zagryazneniya Vodoemov 8: 295-300: cited in Evaluation of|the sensitivity of immunological tests for hygienic|normalization of harmful substances in reservoir waters.|Chem Abstr 69: 12852s (1968)
Method: other: no further information given
Lewis, R. J. (1996), Sax's Dangerous Properties of|Materials. 9th ed. New York Van Nostrand reihold, 1905-1906
Schaubschlaeger, W.W. et al., Int. Arch. Allergy Appl.|Immunol. 96, 97-101 (1991)
BASF (DIN 52900) Safety Data Sheet - DIMETHYLACETAMIDE-June|1990.
BASF (1964) Skin irritation in rabbits (XIV/235-239; 247).|BASF AG, Department of Toxicology, 01.10.1964 (unpublished|data)
Skin irritation / corrosion, IUC4#12/Ch.5.2.1
Boutet, C., Chaisemartin, C. (1973). Propriétés toxiques|spécifiques des sels métalliques chez Austropotamobius|pallipes pallipes et Orconectes limosus. C.R. Soc. Bio.|167(12):1933-1938.
Salmonella Typhimurium: TA-1535, TA-1537, TA-98 and TA-100|; Escherichia coli: WP2 uvrA
Belly,R.T., Goodhue,C.T., International Biodegradation|Symposium (London), Proc. Int. Biodegrad. Symp. 3rd,|1103-1107, 1976, No information
Method: other: 14-C Degradation with synthetic photolaboratory effluent
Biodegradation in water: screening tests, IUC4#7/Ch.3.5
Lanxess (2005). Sicherheitsdatenblatt (Material Safety Data Sheet of) 1,4-Dichloro-2-butene. No. 013173/12, 2005-02-16.
Unpublished Report (1992) Gene Mutation Assay in Chinese|Hamster V79 Cells (HGPRT), unpublished report number 92/AKL149/0060. February 20, 1992 as conducted by LSR (Delamine).
Tomlinson, T.G., Boon, A.G. and Trotman, C. N. A. (1966). J.|appl. Bact. 29, 2, 266-291
Loprieno, N. et al.: Mutat. Res. 26, 83-87 (1974)
Genetic toxicity in vitro, IUC4#65/Ch.5.5
EUCLID-Datensatz Natriumpersulfat, CAS-Nr. 7775-27-1,|Degussa AG, Hanau vom 31.05.1994
Industrial Bio-Test Laboratories, Inc., Data Sheets|26-4/1973. As cited in: The Registry of Toxic Effects of|Chemical Substances (RTECS). 2-Naphthol. RTECS# QL2975000.|Update July 2000.
Sobti RC, Mundra P, Sharma M (1985) Effect of an aromatic|amine, o-toluidine on the chromosomes and sperm head of|mice: Chrom Inf Serv 39: 5-7
Genetic toxicity in vivo, IUC4#22/Ch.5.6
Mallette, F.S., von Haam, E. (1952): A.M.A. Arch. Ind. Hyg.|Occup. Med. 5, 311 - 317
Gloxhuber C, Hecht G, Kimmerle G (1962). Toxikologische|Untersuchungen mit Aufhellern (Blankophor-Typen). Archiv für|Toxikologie 19, 302-312.
VanderPloeg, LC. et al.: J. Environ. Pathol. Toxicol. Oncol.|11 (3), 177-189 (1992)
Institut Fresenius (2000) Study on the Acute Toxicity|towards Fish of 3-Mercaptopropionic Acid according to OECD|Test Guideline 203. Study Number IF-99/22017-00
European Chemicals Agency / Helsinki / Finland
Bracher M, Wisak J, Noser F (1981) Studies on the potential in vivo inducation of sister chromatid exchanges in rat bone marrow by resorcinol. Mutation Research 91:363-369.
Kirk-Othmer Encyclopedia of Chemical Technology (1995) Y.|LABAT, Fourth edition, Vol. 24, (1995), J. Wiley & Sons ,|Inc.
Bringmann G and Kuehn R (1959). Vergleichende|wasser-toxikologische Untersuchungen an Bakterien, Algen und|Kleinkrebsen. Gesundheits-Ingenieur 80 (4), 115-120.
Method: other: Cell multiplication inhibition test
Zijlstra, J.A. and Vogel, E.W.: Mutat. Res. 201, 27-38|(1988), No information
Method: other: SLRL test and Ring-X loss test
Genetic toxicity in vivo, IUC4#24/Ch.5.6
Stol, M. et al., Biomaterials 9, 273-276 (1988)
Schmelzpunkt, Dampfdruck aus Beilstein 1988-1999, CD-ROM
Reuzel, P.G.J. et al.: J. Toxicol. Environ. Health 29,|279-292 (1990), No information
DAUBERT,T.E.; DANNER, R.P.; PHYSICAL AND THERMODYNAMIC|PROPERTIES OF PURE CHEMICALS: DATA COMPILATION.; DESIGN |INSTITUTE FOR PHYSICAL PROPERTY DATA, AMERICAN INSTITUTE OF|CHEMICAL ENGINEERS. |HEMISPHERE PUB. CORP., NEW YORK, |NY., 4 VOL.; 1989
Method: other: chambers of 14.5 m3 volume; air flow: 2000-3500 l/min
Lide DR (1990). CRC Handbook of Chemistry and Physics, 71st|Edition. CRC Press, Boca Raton, 3-439.
Method: other (measured): according to OECD-guidelines of commission 67/548/EWG
BASF AG, Department of Toxicology, Ergebnis der|Gewerbetoxikologischen Vorprüfung (XX/174), unpublished|data, 16 Sep 1970
Spruit, W.E.T. 2004. Determination of the water solubility of Butyltrichlorostannane (Monobutyltin trichloride, MBTC, CAS # 1118-46-3). TNO Prins Maurits Laboratory. TNO report PML 2004-C133. November 23, 2004.
Verschueren K (1996). Handbook of Environmental Data on|Organic Chemicals, 3rd ed. New York, Van Norstrand Reinhold,|p 1793.
Dowden, B.F. and Bennett, H.J. (1965) Toxicity of selected|chemicals to certain animals. J. Water Pollut. Control Fed.,|37(9), 1308-1316.
Short-term toxicity to aquatic invertebrates, IUC4#140/Ch.4.2
Ewell W.S. et al., (1986): Simultaneous evaluation of the|acute effects of chemicals on seven aquatic species. Envir.|Toxicol. Chem. vol 5 pp 831-840
Short-term toxicity to fish, IUC4#52/Ch.4.1
Tonogai Y, Ogawa S, Ito Y, and Iwaida M (1983). Studies of|the syncopic effect of aniline derivatives on fish. I. The|problem concerning the determination of median lethal|concentration in fish. Eisei Kagaku 29(5), 280-285.
Bioaccumulation: aquatic / sediment, IUC4#6/Ch.3.7
Applegate VC, Howell JH, Hall JrAE, Smith MA (1957)|Toxicity of 4,346 Chemicals to Larval Lampreys and Fishes.|Spec Sci Rep Fish no. 207, Fish Wildl Serv, U.S.D.I.,|Washington DC, pp 157
Short-term toxicity to fish, IUC4#140/Ch.4.1
Kashkalda DA and Kolodub FA (1988) Impact of|para-nitrochlorobenzene and 2,4-dinitrochlorobenzene on the|state of carbohydrats and energy of metabolism in rats. Gig|Tr Prof Zabol 2: 48-49
RTECS, update 8910: Gig. Truda i Prof. Zabol. 27(5), 60|(1983)
OECD Guideline 403 (Acute Inhalation Toxicity)
BASF AG, Technische Entwicklung Verfahrenstechnik,|unpublished study, J.-No. 36-808, 24.07.1979
Method: other: titration to the point of turbidity; test procedure according to an internal BASF standard
Couch, D.B. et al.: Environ. Mutagen. 4, 336-337 (1982);|abstract Bh-7, No information
Genetic toxicity in vitro, IUC4#47/Ch.5.5
Prival MJ and Zeiger E (1998). Chemicals mutagenic in|Salmonella typhimurium strain TA1535 but not in TA10. Mut.|Res., 412, 251-260.
Spalding JW, Cifone MA, Irwin RD, Dunnick J (1991) A|comparative study of the induction of hepatic UDSs and|S-phase by three mono-nitrotoluene isomers following in vivo|treatment in F344 rats and B6CF1 mice. Environm Molec|Mutagen 17, Suppl 19: 70
Method: other: according to Mirsalis, Carcinogenesis 6, 1521-1524 (1985): 12 week old male rats, UDS measured in primary cultures of hepatocytes derived from rats 12 hrs after treatment
Struijs J, Stoltenkamp J (1986) Ultimate Biodegradation of|2-, 3- and 4-Nitrotoluene. Science Total Environ 57: 161 -|170
Method: other: modified test method described by Pitter in 1976 (similar to OECD302B)
BASF AG (1989). DUU/OU - Department of Ecology, unpublished|calculation, 09 Jan 1989.
Method: other (calculated): pro-logP (CompuDrug Ltd.)
Dieter M.P., Govt Reports Announcement & Index (GRA&I),|Issue 02, 1990
OECD Guideline 451 (Carcinogenicity Studies)
McCord CP (1932) The Toxicity of Allyl Alcohol, Journal of|the American Medical Association 98, 2269-2270
Matsui S. et al., Activated sludge degradability of organic|substances in the waste water of the Kashima petroleum and|petrochemical industrial complex in Japan, Progress in Water|Technology 7 (3/4): 645-659, 1975 (18)
BASF AG, Department of Toxicology, unpublished data,|(XIII/27), 17 Feb. 1964
Leach, C.L., Hatoum, N.S., Zeiss, C.R., and Garvin, P.J. |1989. Immunologic tolerance in rats during 13 weeks of|inhalation exposure to trimellitic anhydride. Fundamental|and Applied Toxicology. 12: 519-529.
Repeated dose toxicity: inhalation, IUC4#4/Ch.5.4
Laboratoire national de la Santé, EEC study BCO-P assay,|01.06.92
Method: other: Directive84/449/EEC, B.5 <<Acute Toxicity (eye irritation)>>
Gerike P, Fischer WK. (1979) A correlation study of|biodegradability determinations with various chemicals in|various tests. Ecotox Environ Safety 3, 159-73.
Biodegradation in water: screening tests, IUC4#16/Ch.3.5
Monsanto Co (1980a) A Teratogenic Study with|p-Nitrochlorobenzene in rats. Project No. 79-2416B|(BD-79-327), Final Report, Contractor: Bio/dynamics Inc.,|report submitted to: Monsanto Co., Date: June 4, 1980,|EPA-OTS0557073
Method: other: according to OECD Guide-line 414: 24 mated rats per group, see also freetoxt ME
National Institute of Environment Research(NIER), Korea(2001), Estimation of physical/chemical properties and environmental fate of SIDS chemical
Method: other: Method/guideline followed: Internal Union Carbide method for inhalation exposure.
Acute toxicity: inhalation, IUC4#20/Ch.5.1.2
Kim, J. and Levin, R.E.: Microbios 46, 15-20 (1986);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Greene and Friedman (1979) Short-Term Mutagenicity and Cell Transformation Screening of Toluene Diamine. Report No. MA-12-77-12. Allied Chemical Corporation.
Method: other: calculated: SRC-MPBWIN v1.40
Abe T, Saito H, Niikura Y, Shigeoka T, and Nakano Y (2001).|Embryonic development assay with Daphnia magna: Application|to toxicity of aniline derivatives. Chemosphere 45, 487-495.
Cairns et al. (1978): Effects of temperature on aquatic|organism sensitivity to selected chemicals. VA Water|Resource Center, Bulletin 106, Office of Water Res.|Technol., OWRT project B-084-VA, VA. polytech. Inst. State|Univ., Blacksburg, VA, 88 p.
Method: other: Invertebrate toxicity test
Short-term toxicity to aquatic invertebrates, IUC4#31/Ch.4.2
Method: other: Algal Photosynthesis Bioassay
Luecken J.J and Sullivan, A.B. (1981), Stability of Benzothiazole Sulfenamide Accelerators, Elastomerics, August, p34-44
Guillot, J.P. and Gonnet, J.F.: Curr. Prob. Dermatol. 14,|220-247 (1985), No information
Eller, H.; Dissertation: Beitrag zur Toxikologie|Technischer Weichmacher (1937)
Acute toxicity: inhalation, IUC4#70/Ch.5.1.2
Stoner G., Shimkin M., Kniazeff A., et al, 1973, Test for carcinogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A Mice, Cancer Research 33, 3069-3085
Videau et al.(1979): Preliminary results concerning effects|of chlorine on monospecific marine phytoplankton. J .Exp.|Mar. Biol. Ecol., 36(2), pp 111-123.
Toxicity to aquatic algae and cyanobacteria, IUC4#9/Ch.4.3
MHLW, Japan (2000). Ministry of Health, Labour and Welfare,|Toxicity Testing Reports of Environmental Chemicals, 8,|1087-1100. (The 28 days repeated dose toxicity test was|performed by the Safety Research Institute for chemical|Compounds Co., Ltd.)
OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity in Rodents)
Smyth, D. A., J. Plant Growth Regul. 11, 125-128 (1992)
You M, Hsu I-C, Morgan M, Stoner GD (1986) Induction of lung|adenomas in strain A mice and DNA strand breaks in human|bronchial epithelial cells with benzotrichloride.|Proceedings of AACR 27: 94
Andersen, K.E. et al.: Contact Dermatitis 10, 257-266 (1984), No information
Ballantyne B and Vergnes JS. 2001. In vitro and in vivo|genetic toxicology studies with diethylene glycol monohexyl|ether. J Appl Toxicol 21:449-460.
Method: other: internal company protocol
BASF AG, unpublished calculation data; 05. March 2004
Method: other (calculated): with AOP Program v1.90
RTECS update 8910: Gig. Truda i Prof. Zabol. 27(5), 60|(1983)
Acute toxicity: inhalation, IUC4#5/Ch.5.1.2
Zimmermann, F.K. and Mohr, A.: Mutat. Res. 270, 151-166|(1992), No information
Genetic toxicity in vitro, IUC4#147/Ch.5.5
Feron, V.J. et al.: Toxicol. Ind. Health 6, 637-639 (1990), No information
Bhalla, D.K. et al.: J. Toxicol. Environ. Health 33,|171-188(1991), No information
BASF AG, 1989, Analytical Laboratory, Bestimmung des|Verteilungskoeffizienten log Pow der Prüfsubstanzen in|1-Octanol/Wasser bei 25°C, unpublished study, J. No. |106288/13, 08 May 1989
Method: other (measured): Determination of the logPow using gas chromatographic methods
IRDC (1965) Acute Oral Toxicity (LD50) in the Albino|Rat. International Research and Development Corporation|(IRDC). Study #: 164-010. Study Date: November 19, 1965.
Method: other: Conforms with acute toxicity studies performed during the 60's and 70's; pre-dates OECD and GLP.
MRID# 42537801. Determination of Water Solubility of Methyl|Bromide. Literature Search Submission containing 3 studies.|October 30, 1992.
Schering AG. 1969. Systemische Verträglichkeitsprüfung bei einmaliger Verabreichung. DL50. Prot. Nr. 1303. 03.06.1969.
Corning Hazelton, CHV Study No. 16595-0-409, June 1995,|sponsored by Color Pigments Manufacturers Association
Method: other: Maron and Ames, Mutat. Res. 113, 173-215 (1983)
BASF (1988) Toxicity to Scenedesmus subspicatus (0040/88).|BASF AG, Department of Ecology, 10.06.1988 (unpublished|data)
Method: other: method corresponds in principle to DIN 38412, part 9, Determination of inhibitory effect on the cell multiplication (comparable to OECD 201)
Bayer AG, Internal studies: 1. Geschlossener Flaschen-Test|(1977), 2. Test on Leuciscus idus (1974), Oxygen consumption|inhibition test according to Robra (1983); no records|available
Method: other: Bestimmung der Wirkung von Wasserinhaltsstoffen auf Fische, DIN 38412 Teil 15
Stern ML, Brown TA, Brown RD, and Munson AE (1989). Contact hypersensitivity response to isophorone diisocyanate in mice. Drug Chem. Toxicol. 12, 287-296.
Method: other: based on the method described by Gad et al., Toxicol. App.l Pharmacol. 84, 93 (1986)
Munch, J.C. H.J. Pratt, L.M. Acetanilide studies I. Acute toxicity. J. Am. Pharm. Assoc., Sci. Ed. 30, 91-98, 1941
ICI Ltd (1970). Toxicological report: 4,4'dichlorodiphenyl sulphone. Report Number HO/IH/T/793.
Hooftman, R.N. and J.M. de Wolf. 2003. 1,3,2-Dioxastannepin-4,7-dione, 2,2-dibutyl- (dibutyltin maleate, CAS# 78-04-6): Static acute toxicity test with the crustacean species Daphnia magna. TNO Report No. V4017/04. September 2003.
Hamlin et al., 1971; available from EPA/OPTS Public Files,|Fiche # OTS0516114, Docket #86-870001211.
Khadzhieva, E.D., Gig.Tr. Prof. Zabol. 13, 22-25 (1969),|zitiert nach: IARC Monographs on the Evaluation of the|Carcinogenic Risk of Chemicals to Humans, Vol. 39,|International Agency for Re- search on Cancer, Lyon, 247-275|(1985)
Monsanto Company, A teratology study in rats with|o-nitrochlorobenzene and a modified teratology study in rats|with o-nitrochlorobenzene, EPA OTS0524332,1990
Method: other: 25 females/group, due to severe mat. tox. and mortality the 150 mg-level was terminated prior to scheduled sacrifice
Method: other (calculated): SRC-AOP, v 1.90
Wang, M. et al: Yiyao Gongye 17 (8), 349-354 (1986);|abstract;|cited in: RIFM database, location no. 5930
Developmental toxicity / teratogenicity, IUC4#25/Ch.5.8.2
von der Hude, W. et al. (1988): Mutat. Res. 203, 81 - 94
Genetic toxicity in vitro, IUC4#261/Ch.5.5
Bringmann, G. und Kuehn, R., Z. Wasser-Abwasser-Forschung|10(5), 161-166 (1977)
Sax, N.I. and R.J. Lewis, Sr. (eds.). 1987. Hawley's Condensed Chemical Dictionary. Eleventh Edition. Van Nostrand Reinhold Company. New York, NY. 1288p.
O'Donovan, M.R. and Mee, C.D.: Mutagenesis 8, 577-581 (1993), No information
Method: other: Maron and Ames, 1983, Mutation Research, 113, 173-215
Genetic toxicity in vitro, IUC4#241/Ch.5.5
Minihan A and Lovell A (2000). "Alkali Silicates". In:|Ullman's Encyclopedia of Industrial Chemistry, 6th Edition,|Electronic Release 2003, Wiley-VCH Verlag GmbH, Weinheim,|Germany.
Brusick, D.J. in: Gibson, J.E. (ed.): "Formaldehyde|Toxicity", Hemisphere Publishing Corp., Washington, New|York, London (1983), chapter 8, pp. 72-84, No information
Genetic toxicity in vitro, IUC4#152/Ch.5.5
Hommel G (ed.) (2005). Handbuch der gefährlichen Güter|(Handbook of Dangerous Goods), data sheet No. 25. Springer|Publishers Berlin - Heidelberg, Germany.
BASF AG (1988). Department of Ecology. Modified OECD|Screening Test, study No. 0048/88, 07 Apr 1988, unpublished.
Method: other: Directive 79/831/EEC, Annex V, Part C3
CERI (2004). Tetrahydrofurfuryl alcohol: CAS No. 97-99-4.|Calculation of|- Melting point with MPBPWIN v.1.41, 2000|- Boiling point with MPBPWIN v.1.41, 2000|- Vapour pressure with MPBPWIN v.1.41, 2000|- Log Pow with KOWWIN v.1.67, 2000|- Water solubility with WSKOW v1.40, 2000|- Indirect Photodegradation with AOPWIN v.1.91, 2000|- Henry's Law Constant with HENRYWIN v.3.10, 2000|- Distribution of tetrahydrofurfuryl alcohol based on|Fugacity model (Levell III) with EPIWIN|- Soil Adsorption Coefficient with PCKOCWIN v.1.66, 2000|- Bioconcentration Factor with BCFWIN v.2.15, 2000
Method: other: calculated by WSKOW v1.40. (2000)
Hossack DJN, Richold M and Richardson JC (1978b).|Micronucleus test on isophorone. Huntingdon Research Centre,|Huntingdon, England, Report UKM 52/78457.
LaLonde RT, Xie S, Bu L (1993). Test of chiral recognition|in the Salmonella typhimurium (TA 100) mutagenicity of|mucochloric acid-cysteine adducts. Environ Mol Mutagen 22:|181-187
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K,|Speck W (1987) Salmonella mutagenicity tests: III. Results|from the testing of 255 chemicals. Environ Mutagen 9, Suppl.|9: 1-110
Method: other: Preincubation assay as described by Haworth et al., Environ. Mutagen. 5 (Suppl. 1), 3-142 (1983)
Aarstad K. et al.: Arch. Toxicol., Suppl.8, 418-421, (1985) as cited in IUCLID.
Method: T26-16:Only the influence of isobutanol on the cytochrome P450 enzyme system was investigated.
Repeated dose toxicity: inhalation, IUC4#40/Ch.5.4
Draize, J. (1958): Dermal toxicity. In: Appraisal of the|Safety of Chemicals in Foods, Drugs and Cosmetics.|Association of Food and Drug Officials, Topeca, Kansas,|U.S., p. 46-59.
Bringmann G., Kühn R. Comparative Findings Concerning the|Harmful Effects of Water Pollutants on Bacteria Pseudomonas|Putida and Blue-Green Algae Microcystis Aeruginosa. GWF-Z.|Wasser Abwasser , 117(9):410-413. 1976.
methylsilanetriyl triacetate (IUC4 DSN 120)
ECETOC, Joint Assessment of Commodity Chemicals, Report No.|25, 1-chloro-1,2,2,2-tetrafluoroethane (HFC-124) CAS No|2837-89-0, 2003.
IRDC (Int. Research & Development Corp): unpubl. report No.|5701-1-307, July 15, 1983a (Short communication)
OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity in Rodents)
Yalkowsky, S.H., and R. M. Dannenfelser. 1992. AQUASOL Database of Aqueous Solubility. 5th Edition. University of Arizona, College of Pharmacy. Tuscon, AZ
US EPA (1994): Acute toxicity of [] containing sodium|bisulfite to rainbow trout (Salmo gairdneri) with cover|letter dated 05/19/94 (sanitized). OTS0556836
Short-term toxicity to fish, IUC4#20/Ch.4.1
International Research and Development Corp. (IRDC), No.|637-002, 17 Dec. 1991 (sponsored by Atrix Lab. Inc. and GAF|Chemicals Corp.)
Method: other: comparable to OECD Guide-line 414
McKenna, M.J., Burek, J.D., Henck, J.W., Whacker, D.L. and|Childs, R.C.: Toxicology Research Laboratory, The Dow|Chemical Company, Midland, MI 48640 (1981a).
Chemfinder (2003). Internet Database:|http://chemfinder/cambridgesoft.com.
Liu DHW, Spanggord RJ, Bailey HC, Javitz HS, Jones DCL|(1983). Toxicity of TNT Wastewaters to Aquatic Organisms,|Volume II. Acute toxicity of condensate wastewater and|2,4-dinitrotoluene. SRI International, Report LSU-4262,|Menlo Park California.
Method: other: EPA test method "Algal Assay Procedures: Bottle Test", 1971
Toxicity to aquatic algae and cyanobacteria, IUC4#40/Ch.4.3
Kawachi T, Yahagi T, Kada T, Tazima Y, Ishidate M, Saski M,|Sugiyama T (1980). Cooperative programme on short term|assays for carcinogenicity in Japan. IARC Sci. Publ. 27,|323-330.
Hill Top-Toxicology. 1978. Extended Acute Oral LD50 Studies of Nine Samples. Ref: 77-1094-21. 26.5.1978.
Applegate VC, Howell JH, Hall AE (1957). Toxicity of 4,346 chemicals to larval lampreys and fishes. Special Scientific Report - Fisheries No. 207, Washington, D.C.
Short-term toxicity to fish, IUC4#80/Ch.4.1
Isomaa, B. et al. (1995): The toxicity of the mutagen "MX"|and its analogue, mucochloric acid, to rainbow trout|hepatocytes and gill epithelial cells and to Daphnia magna,|Toxicology 100, 69 - 77
Method: other: calcein fluoresence intensity
Bringmann G, Kühn R (1981) Vergleich der Wirkung von|Schadstoffen auf flagellate sowie ciliate bzw. auf|holozoische bakterienfressende sowie saprozoische Protozoen.|Gwf Wasser-/Abwasser 122: 308 - 313
Method: other: cell multiplcation inhibition test
Toxicity to microorganisms, IUC4#90/Ch.4.4
Sax NI (1979). Dangerous Properties of Industrial Materials|5th Edition. Van Nostrand Reinhold Co. New York.
Litton Bionetics (1975) Mutagenic evaluation of compound FDA|73-43 sodium sulfite. LBI Project #2468. NTIS PB-245 488, p.|1-44
Method: other: mutagenicity testing by plate test and suspension test
BioReliance (1998) Mammalian erythrocyte micronucleus test|with ethylhexyl thioglycolate. BioReliance no. G98AZ23.123.
Bootman, J., (1986). Mutagenicity test. Metaphase analysis. Human peripheral lymphocytes. Chromosome aberration. Confid. Report NIPA Lab. Ltd. Life Science Res. Mid Clamorgen, GB-CF-38-25N, UK.
Clariant GmbH, (1987) Unpublished testing report titled|"o-Chlorbenzylchlorid D, Akute Aerosolinhalation an der|mannlichen und weiblichen SPF-Wistar Ratte, 4 Stunden -|LC50", Report No.: 87.1003, 14.09.1987, conducted by HOECHST|AG, Pharma Forschung Toxikologie und Pathologie.
Hoechst AG (1981) Acute Toxicity of Resorcin DS in Golden Ide (Leuciscus idus f. melanotus). Report number 200/81.
Method: other: follows all major guidelines
Method: other: Test for inhibition of oxygen consumption by Pseudomonas putida (Hüls Method), 5-6 h
Toxicity to microorganisms, IUC4#6/Ch.4.4
Smyth, H. F. et al.: Arch. Ind. Hyg. Occup. Med. 4, 119-120|(1951)
Melnick R, Sills R, Roycroft J, Chou B, Ragan H and Miller R|(1994). Isoprene, an endogenous hydrocarbon and industrial|chemical, induces multiple organ neoplasia in rodents after|26 weeks of inhalation exposure, Cancer Res., Vol. 54, pp.|5333-5339.
Repeated dose toxicity: inhalation, IUC4#3/Ch.5.4
CERI (2007) Estimation with BCFWIN v2.14.
Dreisbach (1961): Physical Properties of Chemical|Compounds-III, Advances in Chemistry Series No. 29,|Washington, DC, American Chemical Society, 357, 359, 360,|382
BASF AG, Department of Toxicology, unpublished study|(XVII/341), Nov 07, 1967
Method: other: as described by Smyth et al., Am. Ind. Hyg. Ass. J. 23, 95-107, 1962
OECD (2001) SIDS Initial Assessment Report "Disodium|disulphite", CAS-No. 7681-57-4. Prepared for SIAM 13, Bern,|6-9 November 2001
Bringmann, G. und Kuehn, R., Z. Wasser-Abwasser-Forschung|10 (3/4), 87-89 (1977)
Toxicity to microorganisms, IUC4#30/Ch.4.4
Laaksonen M, Maeki-Paakkanen J, Kronberg L, Komulainen H|(2003) Effects of chlorohydroxyfuranones on|3-methylcholanthrene-induced neoplastic transformation in|the two-stage transformation assay in C3H 10T1/2 cells. Arch|Toxicol 77: 594-600
Method: other: non validated method according to Laakson et al. 2001, Arch Toxicol 75: 613-617
Pool, B.L. et al: Fd. Chem. Toxic. 24, 685-691 (1986), No information
Klonne et al. (1987) Fund Appl Toxicol, 9, 557-572
Repeated dose toxicity: inhalation, IUC4#23/Ch.5.4
Ministry of International Trade and Industry (MITI) (1992):|Biodegradation and bioaccumulation data of existing|chemicals based on the Chemical Substance Control Law|(CSCL), Japan. Chemicals Inspection and Testing Institute|(CITI) (ed.); Japan Chemical Industry Ecology - Toxicology|and Information Center 1-27; 4-355
Salmonella typhimurium TA100, TA1535, TA98, TA1537, Escherichia coli WP2 uvrA
Union Carbide Silane A-1120, N(beta-Aminoethyl)|gamma-Aminopropyltrimethoxysilane: Range Finding Toxicity|Studies, Mellon Institute, Report 29-107; November 9, 1966.
Homma, Y. et al.: Cancer Lett. 32, 117-123 (1986), No information
Method: other: initiation-promotion study
Repeated dose toxicity: oral, IUC4#9/Ch.5.4
Method: other: DIN-Standard 38412 L11 (Daphnia short-time test)
Näser, K.-H. (1975): Physikalisch-chemische Rechenaufgaben.|VEB Verlag für Grundstoffindustrie, Leipzig
BASF AG, Department of Toxicology, unpublished data,|substance 77/146, 28.03.1978
Method: other: according to Federal Register 38, No. 187, § 1500.42, S. 27019, 27. Sept. 1973
BASF AG (2002). Experimental Toxicology and Ecology, Triphenylphosphin - Determination of the acute effect on the swimming ability of the water flea Daphnia magna STRAUS, Unpublished Report, Study No. 99/0479/50/1, 30 July 2002.
Method: other: OECD TG 202 (1984), EEC Directive 92/32/EEC (1992)
Alexeeff, G.V., Kilgore, W.W., Munoz, P., Watt, D. 1985.|Determination of acute toxic effects in mice following|exposure to methyl bromide. J. Toxicol. Environ. Health, 15:|109-123.
Wakabayashi, M. et al., Tokyo-to Kankyo Kagaku Kenyusho|Nenpo, 126-128 (1988)
Short-term toxicity to aquatic invertebrates, IUC4#150/Ch.4.2
NTP (1984) In vitro cytogenetic studies with choline|chloride. NTP unpublished results, 28. Sept. 1984
Method: other: see freetext, comparable to OECD Guide-line 479
Gabrielyan, N.J. et al., Gig. Tr. Ptof. Zabol. 10, 40-42|(1975), zitiert nach: IARC Monographs on the Evaluation of|the Carcino- genic Risk of Chemicals to Humans, Vol. 39,|International Agency for Research on Cancer, Lyon, 247-275|(1986)
Method: other: according to Uno Y. et al., Toxicol. Lett. 63, 191-199, 201-209 (1992)
Wegener H., Über die Fortpflanzungsfähigkeit der Ratte nach|Einwirkung von Diäthylenglykol, Arch exper Path u Pharmakol,|220:414-417, 1953
Ciba-Geigy Ltd., Report on the test for acute toxicity of TK|10044 to daphnia magna, Project No. 840055, 12.4.1984.
Bayer AG (2003). Dinitrotoluene 80/20. Calculation of |- Log Octanol-Water Partition Coefficient with KOWWIN|v.1.66, 2000|- Henry´s Law Constant with HENRYWIN v.3.10, 2000|- Indirect Photodegradation with AOPWIN v.1.90, 2000|- Soil Adsorption Coefficient with PCKOCWIN v.1.66, 2000|- Vapour Pressure with MPBPWIN, v.1.40, 2000|- Mackay-Distribution Level I according to Mackay D., 1991.
Method: other (calculation): PCKOCWIN v1.66 (2000)
Adsorption / desorption, IUC4#40/Ch.3.3.2
Method: other: 15 rats/dose group, 7 doses dissolved in polyethylenglycol 400, given by gavage, observation time: 14 d
RCC Ltd. (2006) Methyl 3-Mercaptopropionate: Combined |Repeated Dose Toxicity Study with the Reproduction/|Developmental Toxicity Screening Test in the Rat. |RCC Study Number A74698.
OECD Preliminary Reproduction Toxicity Screening Test (Precursor Protocol of GL 421)
KEMI Report No. 11/94. 1994. Mono- and Di- Substituted Organotins Used as Plastic Additives. L. Freij (ed.). Volume 1. Environmental Hazard Assessment. The Swedish National Chemicals Inspectorate. p. 11.
BASF AG, Department of Toxicology, unpublished data on the|prenatal toxicity of Glyecin A in Wistar rats after oral|administration (2nd study), Report Project No.:|30R0811/89118, 27. Nov. 1995
Method: other: OECD Guide-line 414, 1981
Bigger, C.A. and Sigler, C.I. 1991. CHO/HGPRT mutation|assay with confirmation. Final Report. Microbiological|Associates, Inc. Laboratory Study Number TA039.332001.
Riddick JA, Bunger WB, and Sakano TK (1986). Techniques of|Chemistry. Volume 2: Organic Solvents. 4th edition, Wiley|Interscience, New York, 666.
Callahan MA, Slimak MW, Gabel NW, May IP, Fowler CF, Freed|JR, Jennings P, Durfee RL, Whitmore FC, Maestri B, Mabey WR,|Holt BR and Gould C (1979). Water-related environmental fate|of 129 priority pollutants Vol. 1. U.S. EPA Report No.|440/4-79-029a.
BASF AG, Experimental Toxicology and Ecology, unpublished study, Micronucleus Assay in Bone Marrow Cells of the Mouse with Iso-butylacrylate. (26M0366/019009) November 13, 2001
Method: other: OECD Guideline 474 (1997)
Budavari, S. (ed.): The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ, Merck and Co., Inc., No. 9613(2001)
Ishidate, M.,Jr. et al., Prog. Mutat. Res. 5, 427-432 (1985)
Genetic toxicity in vitro, IUC4#31/Ch.5.5
Putnam, D.L. and Morris, M.J. 1991. Chromosome aberrations|in chinese hamster ovary (CHO) cells. Final Report. |Microbiological Associates, Inc. Laboratory Study Number|TA039.337100.
Hill Top Research. 1969a. Thirteen week dietary|administration of trimellitic anhydride to rats. S-192.
Repeated dose toxicity: oral, IUC4#12/Ch.5.4
Zeiger E. et al.: Salmonella Mutagenicity Tests: III. Results from the Testing of 255 Chemicals, Env. Mutag. 9, Suppl. 9, 1-110, (1987)Z
Method: other: according to Haworth et al.; Environ. Mutagen.,5 (Suppl.1), 3-142, (1983)
BASF AG, department of toxicology, unpublished data,|substance nr. 93/231, 01-15-1997
EU Method B.31 (Prenatal Developmental Toxicity Study)
Stula E.F. et al.(1973). Du Pont - Haskell Laboratory -|Unpublished Data: Pathology Report No. 60-73.
Pohl E (1975). Biological elimination of TINOPAL DMS h. c.|114%. Ciba-Geigy AG Basel (Dyes and Chemicals Division),|Switzerland; Summary data sheet from 16.05.1975.
OECD Guideline 303 A (Simulation Test - Aerobic Sewage Treatment. A: Activated Sludge Units)
Biodegradation in water and sediment: simulation tests, IUC4#3/Ch.3.5
Honma, T., Miyagawa, M., Sato, M., Hasegawa, H. 1985.|Neurotoxicity and metabolism of methyl bromide in rats. |Toxicol. Appl. Pharmacol., 81:183-191.
Waggy GT. 1987. Glycol ethers: Summary of available ecological fate and effects data. Union Carbide Corporation File No. 35931.
Fukuhara, T. Fujii, N. Watanabe (1978b). Fujisawa|Pharmaceutical Co. Ltd, Central Laboratory. Teratogenicity|study of glucono-delta-lactone in rat (Oral dosing).
Developmental toxicity / teratogenicity, IUC4#5/Ch.5.8.2
Forward MV, Bowden ST and Jones WJ (1949). Physical Properties of Triphenyl Compounds of Group Vb Elements, J. Chem. Soc., 5, p. S121 - S126.
Dow Corning Corporation (1966) TOXICOLOGICAL PROPERTIES OF|HEXAMETHYLDISILAZANE (Z-6080, LOT 6); 1/12/66; EPA DOC. NO.|86940001071; FICHE NO. OTS0556525; SUBMITTED BY INDUSTRY,|MODIFIED. Cited in NISC and BiblioLine (2009) BiblioLine -|www.nisc.com
Chemicals Evaluation and Research Institute (CERI), Japan|(2003). Unpublished data.
Infracor GmbH, Degussa Group (2002). Determination of the|growth of the green algae Scenedesmus subspicatus. Report|No. AW 495 (unpublished)
Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537
Lee, K.P. & Allen, H.E.: Environmental transformation|mechanisms of thiodiglycol. Environ. Tox. Chem. 17,|1720-1726 (1998)
Salmonella typhimurium/strains TA-1535, TA-1537, TA-1538, TA-98, TA-100; Escherichia coli/ WP2uvr A
Meinck, F. et al., Industrie-Abwaesser, p. 41 (1968)
Kuehne R, Ebert R-U, Keint D, Schmidt G, Schüürmann G (1995)|Group Contribution Methods to Estimate Water Solubility of|Organic Compounds. Chemosphere 30 (11): 2061 - 2077
Melting point/freezing point, IUC4#6/Ch.2.1
Short-term toxicity to fish, IUC4#47/Ch.4.1
O'Connor, B.J. and D.M. Mullee. 2004. Tetrabutyltin (CAS No. 1461-25-2): Determination of General Physico-Chemical Properties. SafePharm Laboratories, Derbyshire, U.K. SPL Project Number: 445/448.
Wantanabe et al. (1991) Eisei Kaguku 37:512-521.
Short-term toxicity to fish, IUC4#60/Ch.4.1
OECD Guideline 204 (Fish, Prolonged Toxicity Test: 14-day Study)
Fortman,L., Rosenberg,A., Chemosphere 13, 53-65, (1984)
Biodegradation in water: screening tests, IUC4#12/Ch.3.5
Matsuda T, Yano T, Maruyama A, and Kumagai H (1994).|Antimicrobial activities of organic acids determined by|minimum inhibitory concentration at different pH ranged from|4.0 to 7.0. Nippon Shokuhin Kogyo Gakkaishi 41(10), 687-702.
Toxicity to microorganisms, IUC4#17/Ch.4.4
CIT (2005) Evaluation of Skin Sensitization Potential in Mice Using the Local Lymph Node Assay (LLNA). CIT, Evreux, France. Study number: 26940 TSS. Study sponsor: L'Oreal.
CEES (2003). Soluble Silicates. Chemical, toxicological,|ecological and legal aspects of production, transport,|handling and application. Centre Européen d'Etude des|Silicates, Brussels, Belgium.
HSDB database (through 2004/11). Available online via TOXNET|at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB.
DeSerres, F.J. and Brockman, E. : Prog. Clin. Biol. Res.|209A, 209-218 (1986), No information
Genetic toxicity in vitro, IUC4#63/Ch.5.5
Working, P.K., Doolittle, D.J., Smith-Oliver, T., White,|R.D., and Butterworth, B.E.: Mutat. Res., 162:219-224|(1986).
Method: other: in general conformance with OECD 482
Covance Laboratories (2005) In vivo rat micronucleus assay in Resorcinol (AO11). Study number 6182-114. Genetic toxicology assay number 26557-0-454 OECD. Study sponsor: L'Oreal.
Berol Nobel AB (1993) Unpublished report. The Acute Toxicity of|Aminoethylpiperazine to Daphnia Magna Project Number|142/125. Performing Laboratory: Safepharm Laboratories|Limited, Derby, UK. 1993
Bayer AG (2003). o-Toluidine, CAS-No. 95-53-4. Calculation|of|- Log Octanol-Water Partition Coefficient with KOWWIN v.|1.67, 2000|- Henry´s Law Constant with HENRYWIN v. 3.10, 2000|- Henry´s Law Constant according TGD, 2003|- Indirect Photodegradation with AOPWIN v. 1.91, 2000|- Soil Adsorption Coefficient with PCKOCWIN v. 1.66, 2000|- Soil Adsorption Coefficient according TGD, 2003|- Bioconcentration factor with BCFWIN v.2.15, 2000|- Mackay-Distribution Level I according to Mackay D., 1991.
Method: other (calculated): with AOPWIN v. 1.91 (2000)
Color Index (2002). Colour Index International, Society of|Dyers and Colourists and American Association of Textile|Chemists and Colourists.
Levy et al., 1983, Induction of cytogenetic effects in human|fibroblast cultures after exposure to formaldehyde or|X-rays, Mut. Res. 119, 309 - 317, No information
Genetic toxicity in vitro, IUC4#348/Ch.5.5
Hoechst AG (1974): Unveroeffentlichte Untersuchung|(18.01.1974)
Hoechst AG (1975) Haut- und Schleimhautvertraeglichkeit von|Nitro-o-dichlorbenzol-4,1,2 an Kaninchen (unpublished report|no. 501/75). Hoechst AG, Frankfurt
Method: other: according FDA directive: Federal Register 38, No. 187, see also freetext ME
Przytocka-Jisiak, M. et al, ACTA MICROBIOLOGICA|POLONICA,26(2), 185-197 (1977)
De Flora S, Camoirano A, Zanacchi P, Bennicelli C (1984)|Mutagenicity testing with TA97 and TA102 of 30 DNA-damaging|compounds, negative with other Salmonella strains. Mutat Res|134: 159-165
Method: other: liquid micromethod procedure
Bemis, Dindorf, Harwood, Samans. (1982) Kirk-Othmer|Encyclopedia of Chemical Technology 3rd Ed Vol 17, 734
Poznak, A.V. and Artusio Jnr, J.F. Anesthetic properties of|a series of fluorinated compounds. Toxicol Appl Pharmacol,|Vol 2, 363-373, 1960.
De Groot WA (2003). The toxicity of bis(4-chlorophenyl) sulfone to the alga Selenastrum Capricornutum. Solvay Pharmaceuticals Int. Doc. No. 7810/0032/2003.
BASF AG, 2003, Department of Product Safety, unpublished|calculation, SRC MPBPWIN v1.40, 25 June 2003
Method: other (calculated): using MPBPWIN v1.40 (Modified Grain Method)
Salmonella typhimurium TA 98, TA 1535, TA 1537, TA 1538, G46, TA1000, C3076, D3052, Escherichia coli WP2 and WP2uvrA-
National Institute of Technology and Evalauation (1993)|Biodegradation and Bioconcentration|of Existing Chemical Substances|under the Chemical Substances Control|Lawhttp://www.safe.nite.go.jp/data/hazkizon/pk_e_kizon_data_|rsult.home_data
Bentley, K.S., (1994). Detection of single strand breaks in|rat testicular DNA by alkaline elution following in vivo|inhalation exposure to methyl bromide. Unpublished report|from E.I. DuPont Haskell Laboratories Project no. 9714-001:|MBIP/21/ALK/HASK:999.
Method: other: Testicular DNA Alkaline Elution
MOE, Japan (2003): Unpublished data, Acute and chronic|eco-toxicity tests of 2-Furanmethanol, tetrahydro- to a|freshwater alga, daphnids and fish
Verrett, M.J. et al., Toxicol. Appl. Pharmacol. 56, 265-273|(1980)
Grafstrom, R.C. et al.: Prog. Clin. Biol. Reports 209A,|255-265 (1986), No information
Method: other: alkaline elution assay (DNA-protein crosslinks)
Genetic toxicity in vitro, IUC4#211/Ch.5.5
Oda, Y. et al.: Mutat. Res. 130, 375 (1984); abstract no. 44, No information
Genetic toxicity in vitro, IUC4#141/Ch.5.5
Pohl, J.: Zur Kenntnis des Dicyandiamids, J. Parkt. Chem.,|15, 534(1923)
Kobayashi H, Ichikawa H, Kamiya N, Yoshida S, Hiraga K|(1976) The results on the acute toxicities of food|additives. Ann Rep Tokyo Metr Res Lab PH 27-2: 159-160
Zhao, Y.-H. et al., Quantitative Structure-Activity|Relationships of Nitroaromatic compounds to Four Aquatic|Organisms, Chemosphere, Vol. 34, 8, 1837-1844 (1997)
Method: other: comparable to OECD 202 part I (Daphnia, Acute Toxicity, 1984)
Monsanto (1979) Environmental Persistance Screening of|Selected Rubber Chemicals. Unpublished study ES-78-SS-28
Method: other: Monsanto Laboratory protocol; see test conditions
Bayer Industry Services (2005). Dicyclohexylamine (neutral|and protonated form) CAS-No. 101-83-7. Calculation of|- Water Solubility with WSKOW v.1.41, 2000|- Vapour Pressure with MPBPWIN v.1.41, 2000|- Melting Point with MPBPWIN v.1.41, 2000 |- Log Octanol-Water-Partition Coefficient with KOWWIN v.|1.67, 2000|- Henry's Law Constant with HENRYWIN v. 3.10, 2000|- Indirect Photodegradation with AOPWIN v. 1.91, 2000|- Soil Adsorption Coefficient with PCKOCWIN v. 1.66, 2000|- Bioconcentration Factor with BCFWIN v. 2.15, 2000|- Mackay-Distribution Level I according to Mackay D., 1991.
Method: other: (calculated) SRC-BCFWIN v2.15
Bioaccumulation: aquatic / sediment, IUC4#10/Ch.3.7
BASF AG, Department of toxicology, unpublished study, Chronic Toxicity and Oncogenicity of Inhaled Methyl|Acrylate and n-Butyl Acrylate in Sprague-Dawley Rats,|(77/1023), 03-01-1985
FMC Corporation, Acute toxicity of sodium persulfate to|rainbow trout (Onchorhynchus mykiss), Study no.|I92-1251, 1993.
Hanstveit, R. 2003. Tetraoctylstannane (CAS# 3590-84-9): Determination of the ready biodegradability in a Manometric Respiration Test. TNO Report No. V4102/01. October 2003.
CIBA-GEIGY, Ltd. 1973. Acute Oral LD50 of TK-11287 in the Rat. Project No. Siss 2503. 09.01.1973.
Clayton, W.R. and Reid, E.E.: Some Esters of thiodiglycol.|J. Am. Chem. Soc. 64, 908-909 (1942)
Hulzebos E.M., et al., Phytotoxicity Studies with Lactuca|sativa in Soil and Nutrient Solution, Environmental|Toxicloegy and Chemistry 12, 1079 - 1094 (1993)
Toxicity to terrestrial plants, IUC4#3/Ch.4.6.2
Hustert K and Parlar H (1981) Ein Testverfahren Zum|Photchemischen Abbau Von Umweltchemikalien in der Gasphase.|Chemosphere 10(9), 1045-1050
Weese H.: Arch. Exp. Pathol. Pharmacol., 135, 118-130, (1928) as cited in IUCLID.
Repeated dose toxicity: inhalation, IUC4#100/Ch.5.4
Pickering Q and Henderson C (1966). Acute toxicity of some|important petrochemicals to fish, J. Water Pollut. Cont.|Fed., Vol. 38, No. 9, pp. 1419-1429.
Masschelein WJ. (1979). Chlorine dioxide - Chemistry and Environmental Impact of Oxychlorine Compounds. Ann Arbor Science.
Method: T16-04:FIFRA Pesticide Assessment Guidelines, subdivision F, Section 81-4, "Primary Eye Irritation Study" TSCA Health Effects Test Guidelines, "Acute Exposure, Primary Eye Irritation"
Budavari, S. (ed.): The Merck Index - An Encyclopedia of|Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ,|Merck and Co., Inc., No. 544(2001)
BASF AG, Safety data sheet 2-METHOXY-2,3-DIHYDRO-4H-PYRAN,|13.02.2003 (30037092)
BASF (1981) Zahn-Wellens test (mucochloric acid; adapted|inoculum). BASF AG, Dpt. of Ecology (unpublished raw data of|14.08.1981 + unpublished reprint of 05.07.2002)
Method: other: static test according to Zahn-Wellens test method (later adapted as OECD Guideline 302B)
Wilmer, J.W.G.M. et al.: J. Appl. Toxicol. 7 (1), 15-16|(1987), No information
Repeated dose toxicity: inhalation, IUC4#117/Ch.5.4
Degussa-Huls AG (1994) Determination of the acute |effects of DYNASYLAN HMDS On the growth of |Scenedesmus subspicatus 86.81.SAG (algae growth|test per Guideline 92/69/EEC). Final Report AW-367.|Degussa-Huls AG-Nr.: 95 0231 DGO. 3/10/1995.
Motoyoshi, K. et al.: Cosmet. Toiletries 94, 41-48 (1979)
Skin irritation / corrosion, IUC4#8/Ch.5.2.1
Canton, J.H. et al., Regul. Toxicol. Pharmacol. 5, 123-131|(1985)
Method: other: according to OECD Proposal (1979: ) Report on the Assessment of Potential Environmental Effects of Chemicals
Biodegradation in water: screening tests, IUC4#4/Ch.3.5
Corning Hazelton, CHV STUDY No. 16595-0-431, Apr. 1996,|sponsored by Color Pigments Manufacturers Association
Method: other: Clive et al., Mutat. Res. 189, 143-156 (1987)
Blunck, J. M. and Crowther, C. E. Enhancement of azo dye carcinogenesis by dietary sodium sulphate. Europ. J. Cancer. 11, 23-31, 1975
BASF AG (2005). Safety data sheet according to 91/155/EEC.|FORMIC ACID 94%, last update 04 Feb 2005.
Schneider, B.A.: "Toxicology Handbook: Mammalian and|aquaticdata. Book 1, Toxicology data"; Washington DC, U.S.|Environmental Protection Agency (Report no.|EPA-540/9-79-003A). NTIS PB-90-196876 (1979);|cited in: IPCS Environ. Health Crit. 89, (1989), No information
Short-term toxicity to fish, IUC4#57/Ch.4.1
Velsicol Chem. Corp. (1979): Acute Toxicity Studies in|Rabbits and Rats. Report 163-661. 13 February 1979. As|submitted to U.S. EPA under TSCA on 20 Nov. 1980, U.S. EPA|TSCA FYI-OTS-1180-0107 IN.
Method: other: 0.5 ml/rabbit, 3 rabbits/sex, examination after 4, 24, 48, 72 h.
Skin irritation / corrosion, IUC4#4/Ch.5.2.1
Marking LL and Bills TD (1976) Invest Fish Control, 72, 11|p.
USEPA (2009) Estimations Programs Interface (EPI) Suite®,|version 4.00.
Hoechst AG (1989): Produktinformation beta-Naphthol der Abt.|Verkauf Feinchemikalien (Maerz 1989)
Muermann P. 1990. Huls Bericht [Report] Number 1752. Prufung auf haustensibilisierende Wirkung am Meerschweinchen von Ethyldiglykilacetat [Test for skin sensitization effect on guinea pigs of diethylene glycol ethyl ether acetate], dated July 24, 1990.
Salmonella typhimurium TA1530, TA1535, TA1538
BASF AG, Abteilung Toxikologie; unveroeffentlichte|Untersuchung (VII/310), 09.12.1958
Procter & Gamble Co (1992). Bingham E, Nord PJ, Stemmer K.|Effect of fluorescent whitening agents on the carcinogenic|activity of ultraviolet radiation II (No date). As submitted|to U.S. EPA under TSCA on Aug. 31 1992, U.S. EPA TSCA;|OTS-538118.
Cesarone CF, Bolognesi C, Santi L (1983) DNA damage induced|in vivo in various tissues by nitrochlorobenzene|derivatives. Mutation Reseach 116: 239-246
Method: other: 12 mice/group, 4 hrs post injection mice were killed, brain, liver and kidney removed: alkaline elution procedure coupled with a microfluorometric method for DNA assay
Pedersen F (1999). Immobilization test of Selected Organic|Amines with the Crustacean Daphnia magna. Report to Danish|EPA, Copenhagen, Denmark, 52.
Method: other: EPA (1992) Daphnid acute toxicity test. 40 CFR Ch. 1 (7-1-92 Edition). § 797.1300, comparable to OECD TG 202
Mashkina OH, Bathisina GS (1971) Toxicology and hygienic|standards for mucochloric acid in the air of a working zone.|Gig Tr Prof Zabol 6: 139-143 (in Russian with English|abstract)
Kusakabe H. et al. (2002). Relevance of chemical structure|and cytotoxicity to the induction of chromosome aberrations|based on the testing reults of 98 high production volume|industrial chemicals. Mutation Research, Vol. 517, 187-198.
Method: other: Guidelines for screening mutagenicity of chemicals (Japan)
EPIWIN (2000). Estimation Program Interface for Windows,|version 3.11. Syracuse Research Corporation, Syracuse, NY,|USA.
BASF (1960) Acute toxicity and skin/eye irritation (X/221).|BASF AG, Department of Toxicology, 09.09.1960 (unpublished|data)
Jenkinson PC and Anderson D (1990) Malformed Foetuses and|Karyotype Abnormalities in the Offspring of Cyclophosphamide|and Allyl Alcohol-Treated Male Rats, Mutation Research 229,|173-184
Toxicity to reproduction, IUC4#3/Ch.5.8.1
Ministry of the Environment(MOE), Japan.(2001), Unpublished|data.
Johnson, W.W. et al. (1980). Handbook of acute toxicity of |chemicals to fish and aquatic invertebrates. Resour. Publ. |137, Fish. Wildl. Serv., U.S.D.I., Washington, D.C.
US National Toxicology Program: Technical Report No. TR 343|(1989)
Ministry of Health & Welfare, Japan (1999b): Toxicity Testing Reports of Environmental Chemicals, vol 7, 262-266, "In Vitro Chromosomal Aberration Test of 2,4-Diamino-6-phenyl-s-triazine on Cultured Chineze Hamster Cells".
Genetic toxicity in vitro, IUC4#30/Ch.5.5
Mueller D, Fritz H, Langauer M, Strasser FF (1975). Nucleus|anomaliy test and chromosomal analysis of bone marrow cells|of the Chinese hamster and dominant lethal test with male|mice after treatment with fluorescent whitening agents.|Environmental Quality Safety 4, 247-263.
Thursby GB, Steele RL and Kane ME (1985). Effect of organic|chemicals on growth and reproduction in the marine red alga|Champia parvula. Environ. Toxicol. Chem. 4, 797-805.
Toxicity to aquatic algae and cyanobacteria, IUC4#20/Ch.4.3
Dean BJ (1985) Summary Report on the performance of|cytogenetic assays in cultured mammalian cells. Prog Mut Res|5: 69-83
Chemicals Evaluation and Research Institute (2004).|Partition Coefficient Study of 4-ethylmorpholine. Report|Number 805290.
Monsanto (1979) Santoflex 13 - Aquatic Toxicity to Fathead|Minnows. Unpublished study No. AB-78-121B
Method: other: Methods for Acute Toxicity Tests with Fish, Macroinvertebrates and Amphibians (US-EPA 1975)
Styles JA and Cross MF (1983). Activity of|2,4,6-trinitrotoluene in an in vitro mammlian gene mutation|assay. Cancer Letters 20, 103-108.
Verschueren K (1996) Handbook of Environmental Data on|Organic Chemicals, 3rd Ed., John Wiley & Sons Inc. New York
Roehrborn, G.: Z. Ernaehrungswissenschaft Suppl. 14, 54-67|(1972);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Genetic toxicity in vivo, IUC4#33/Ch.5.6
Method: other: Validated literature review/calculations
Roth und Daunderer, Giftliste, T 57, 92. Erg. Lfg. 6/2002
Purchase I.H.F.: S. Afr. Med. J., 54, 795-798, (1969); cited in BG Chemie (ed.):2-Methylpropanol-1, in: Toxicological Evaluations 1 - Potential Health Hazards of Existing Chemicals, Springer Verlag, Berlin, pp. 43-57, (1990) cited in IUCLID (2000).
Wide M (1984). Effect of short-term exposure to five|industrial metals on the embryonic and fetal development of|the mouse. Environ Res 33, 47-53.
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test)
Epona Associates, LLC. 2006. IUCLID Data Set: 2-Ethylhexyl Mercaptoacetate [CAS No. 7659-86-1]. 30.05.2006.
Method: other: equivalent to OECD Guide-line 401
Method: other: FHSA test specified in 16 C.F.R. 1500.41 et.seq.
Hooftman, R.N. and J.M. de Wolf. 2003. Butyltrichlorostannane (CAS# 1118-46-3): Static acute toxicity test with the crustacean species Daphnia magna. TNO Report No. V2494/02. August 2003.
Bayer AG: Loeser E (1978). Dicyclohexylamin, akute orale|Toxizitaet. Short report, 30.10.1978.
Method: other: single oral appl. by gavage, undiluted TS., 5 doses, observation time 14 d, determination of signs of intoxication, stat. method: probit analysis.
Sleight BH and Macek KJ (1972). Acute toxicity of FA 10,|FA11, FA12 to rainbow trout (Salmo gairdneri) and channel|catfish (Ictalurus punctatus). Bionomics Inc., 790 Main|Street, Wareham, Massachusetts (USA).
Method: other: Standard Methods (USPHA) 1970 edition
Bayer AG 1984, Internal Study, Toxicity of BHT to bacteria|(Pseudomonas putida)
Method: other: Bewertung toxischer Wasserinhaltsstoffe aus ihrer Inhibitorwirkung auf die Substratoxydation von Pseudomonas Stamm Berlin mit Hilfe polarographischer Sauerstoffmessungen. Robra, K.H.: gwf wasser/abwasser 117 (2), 80-86 (1976)
Hazelton Laboratories America, Inc. 1976. LC50 of Dioctyltin Dichloride in Rats. Final Report. 02.11.1976.
BFR (2005). CHEMIS-CIVS database, online research at|http://bfr.zadi.de/civs/index.cfm, 07 Feb 2005.
Redmond, J.M. and Stebbins, K.E. (1998) |Aminoethylpiperazine: Dermal probe and 28-day repeated|dermal study of systemic toxicity in Fischer 344 rats.|Unpublished Dow Chemical Company report.
Repeated dose toxicity: dermal, IUC4#2/Ch.5.4
Repeated dose toxicity: inhalation, IUC4#60/Ch.5.4
Method: other: Test performed according to the method of Schultz (1997) Toxicol. Methods, 7, 289-309
Fahrig R.: J. of environmental Pathology, Toxicology and|oncology, 16 (4): 273-279, (1997)
Genetic toxicity in vitro, IUC4#73/Ch.5.5
Method: other: according to Smyth, H.F. et al., Am. Ind. Hyg. Ass. J. 23, 95-107 (1962)
Bayer AG (1982) Internal Study 7900256-332 (1982-10-04) |- Acute toxicity test with Brachydanio rerio according to|UBA-Proposal of 1982.06.01 |- Toxicity to Pseudonomas putida according to Robra test |- Biodegradation of 3,4-Dichlornitrobenzene according to|OECD 301D
Biodegradation in water and sediment: simulation tests, IUC4#88/Ch.3.5
Thursby GB and Steele RL (1986). Comparison of short- and|long-term sexual reproduction tests with the marine red alga|Champia parvula. Environ. Toxicol. Chem. 5, 1013-1018.
Toxicity to aquatic algae and cyanobacteria, IUC4#60/Ch.4.3
Miltenburger, H.G. et al.: "Lokale Gentoxizitaet des|Formaldehyd", Schriftenreihe der Bundesanstalt fuer|Arbeitsschutz (1991), No information
Genetic toxicity in vitro, IUC4#85/Ch.5.5
Yamaguchi N, Ohmori H, Welikala N, and Nasu M (1997).|Biodegradability of chemical compounds in newly developed|modified river Die-away Test. Jpn. J. Toxicol. Environ.|Health 43 (4), 209-214.
Method: other: modified river die-away test (TOC-HANDAI)
Method: other: method of Stephens (1967)
IPCS (1999): Isobutylidenediurea, no. 1279, March 1998.
Ullmann's encyclopedia of industrial chemistry (1987).|Cyclododecanol, cyclododecanone, and laurolactam. 5th ed.,|Vol. A8, p. 202-203, VCH Verlagsgesellschaft, Weinheim
Kato, N., Morinobu, S., Ishizu, S. 1986. Subacute inhalation|experiment for methyl bromide in rats. Ind. Health|24:87-103.
Toxicity to reproduction, IUC4#7/Ch.5.8.1
BASF AG (1994) ABT Toxikologie, unpublished report 88/290, 25.01.1989
Method: other: according to guideline DIN 38412
Akademie der Landwirtschaftswissenschaften der DDR, Institut|fuer Pflanzenschutzforschung, Kleinmachnow; Bergmann, H. et|al.; Patentschrift, DD, 221 058 A1 (1985).
Method: other: irrigation (soil covered)
BASF AG, Analytisches Labor, unveröffentlichte Untersuchung,|Bericht zu J.Nr.: 130239/02, 28.10.1988
Garberg, P. and Bolcsfoldi, G.: Environ. Mutagen. 7, 73|(1985); abstract, No information
Method: other: alkaline unwinding assay (DNA strand breaks)
Genetic toxicity in vitro, IUC4#180/Ch.5.5
Tice R, Boucher R, Luke C, Paquette D, Melnick R and Shelby|M (1988). Chloroprene and isoprene: cytogenetic studies in|mice. Mutagenesis 3 (2), 141-146.
APCI, 1,4-Diazabicyclo[2.2.2]Octane: Determination of Ready|Biodegradability: Carbon Dioxide (CO2) Evolution Test|(Modified Sturm Test) (OECD 301B), unpublished study, APCI|RRRS EXT-99/098, 11 Feb 2000
NTP (National Center for Toxicologial Research): Acute|Toxicity Report On Caffeine|(3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione) in Fischer|344 Rats, Final Report, NCTR Techn. Rep. for Expt. No. 374|(NTP Expt. No. 0501102) (1982a)
Method: other: National Toxicology Program (NTP)
Hoechst AG (1992): Unveröffentl. Unters. (Ber.-Nr. 92.1212|vom 22.01.1993)
Sigma-Aldrich Chemie GmbH (2004). Safety data sheet, formic|acid 88-91 %, update 22 Nov 2004.
BASF AG, Laboratory of Ecology and Environmental Analytics,|unpublished data (1023/88)
Method: other: Scenedesmus Cell Multiplication Inhibition Test, DIN 38412 part 9 (draft)
Loarca, F.P. et al.: Environ. Mol. Mutagen. 14, suppl.15,|117 (1989); abstract no. 336, No information
Genetic toxicity in vivo, IUC4#51/Ch.5.6
Method: other: Federal Hazardous Substances Labeling Act (FHSLA), Federal Register Aug. 12, 1961, p 7333-7341, Part 191 "Hazardous Substances Definitions and Procedural and Interpretative Regulations, Final Order"
Method: other: Estimated using MPBPWIN (ver. 1.40)
Walles SA (1992) Mechanisms of DNA damage induced in rat Hepatocytes by quinones. Cancer Letters 63:47-52.
Genetic toxicity in vitro, IUC4#42/Ch.5.5
MHLW(Ministry of Health, Labour and Welfare),Japan,Toxicity|Testing Reports of Environmental Chemicals,9,413-442(2002)
Dow Corning Corporation (1981) Dow Corning Corporation|Internal Report No 1981-I0005-0899
Nichols HP, Ebron-McCoy MT, Andrews JE (1996). The effects|of formate on cd-1 mouse limb bud development. Teratology|53, 118-119.
Tanii H. und Hashimoto K.: Toxicol. Lett. 11, 125-129,|(1982)
MITI (Ministry of International Trade and Industry)(1992)|Biodegradation and Bioaccumulation Data of Existing|Chemicals Based on the Chemical Substances Control Law|(CSCL). Japan. Chemicals Inspection and Testing Institute|(CITI, ed.); Japan Chemicals Industry Ecology-Toxicology and|Information Center 3 - 45
Method: other: Japanese Guideline by MITI of 1974; corresponds to OECD 301C Modified MITI Test
Biodegradation in water: screening tests, IUC4#20/Ch.3.5
Daubert, T.E., R.P. Danner. Physical and Thermodynamic|Properties of Pure Chemicals Data Compilation. Washington,|D.C.: Taylor and Francis, 1989., p. cited in HSDB 21 Sep|2006
RTECS (2001) Registry of Toxic Effects of Chemical|Substances. RTECS No. AS7700000, Update through 2001/01
NIOSH (2003). International Chemical Safety Cards Phosphorus|Trichloride (WHO/IPCS/ILO). National Institute for|Occupational Safety and Health|http://www.cdc.gov/niosh/ipcsneng/neng0696.html.
Bayer AG (1984) Internal Study 8001531-1093 (1984-03-30) |- Acute toxicity test with Brachydanio rerio according to|UBA-Proposal of 1982.06.01 |- Toxicity to Pseudonomas putida according to Robra test |- Biodegradation of 3,4-Dichloronitrobenzene according to|OECD 301D
Biodegradation in water: screening tests, IUC4#90/Ch.3.5
BASF AG, Labor Oekologie; unveroeffentlichte Untersuchung [ Ecology Laboratory, unpublished study], (1221/89)
Method: other: Daphnien-Kurzzeittest [Daphnia short-time test], DIN 38412 Teil [Part] 11, Bestimmung der Wirkung von Wasserinhaltsstoffen auf Kleinkrebse [Determination of the effect of water contaminants on small crustaceans]
Chemicals Evaluation and Research Institute (CERI), Japan|(1999a). Unpublished report
BASF AG (1969) Acute oral toxicity of choline chloride 50%|powder. Department of Toxicology, unpublished results, Study|No. XIX/271, 14.08.1969
Calhoun LL and Johnson KA (1984) "Propylene glycol monomethyl ether (PGME): 21-day dermal study in New Zealand white rabbit", unpublished study of the Dow Chemical Company.
Repeated dose toxicity: dermal, IUC4#16/Ch.5.4
CIBA-GEIGY, Ltd. 1988. Report on the Test for Acute Toxicity of TK 10976 to Daphnia magna. Project No.: 884107. 22 March 1988.
Seegert, G.L., Brooks, A.S. (1978); The effects of|intermittent chlorination on coho salmo, alewife, spottail|shiner and rainbow trout; Trans. Am. Fish. Soc., 107(2),|346-353.
Bruce, W.R., Heddle, J.A. (1979): Can. J. Genet. Cytol. 21,|319 - 334
Genetic toxicity in vitro, IUC4#293/Ch.5.5
Mazayev, V.T., A.A. Korolev, and I.N. Skhachkova. 1971. Experimental investigation of the toxic effect of tetraethyltin and dichlorobutyltin on the animal organism. J. Hyg. Epidemiol. Microbiol. Immunol. 15:115-120.
Report to National Toxicology Program, Assessment of Contact|Hypersensitivity to Butyl Acrylate in Female B6C3F1 Mice.,|Protocol BAC-3-1-TO (Imm95005).
Fukushima, S. et al. (1987): Cancer Lett. 34, 83 - 90
Method: other: Bladder Carcinogenesis Promotion Assay
Hellmer, L. and Bolcsfoldi, G.: Mutat. Res. 272, 145-160|(1992), No information
Genetic toxicity in vitro, IUC4#231/Ch.5.5
Huang, G., H. Sun, and S. Dai. 1997. Quantitative structure-activity relationship study for toxicity of organotin compounds on algae. Bull. Environ. Contam. Toxicol. 58:299-304.
Method: other: Quantitative Structure-Activity Relationship (QSAR)
RCC Ltd. (2008) 3-Mercaptopropionic Acid: Determination |of the Water Solubility. Study Number B57881.
Dutertre-Catella H (1976). Contribution a l'etude analytique|toxicologique et biochimique de l'isophorone. Thesis,|Universite Rene Descartes, Paris.
Combined chronic toxicity/oncogenicity study with HCFC-124. |Two-year inhalation study in rats. E.I du Pont de Nemours|and Company, Haskell Laboratory for Toxicology and|Industrial Medicines, Delaware, HLR No., 60-95, August 1995.| ||Malley, L.A., Frame, S.R., Elliott, G.S., Bentley, K.S.,|Brock, W.J., Trochimowicz, H.J. and Rusch, G.M. Chronic|toxicity, oncogenicity, and mutagenicity studies with|chlorotetrafluoroethane (HCFC-124). Drug and Chem Toxicol,|Vol 21 (4), 417-447, 1998.
Method: other: EPA OTS 798.3320 and OECD test guidelines 453
Maibach HI. Draize type sensitization study FDA optical|brighteners. 1971. One page summary.
Method: other: Human Repeat Insult Patch Test
Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA1538, G46, C3076, D3052, Escherichia coli WP2, WP2 uvrA
Tschernikowa W.W. et al.: Khim. Prom. St. Ser.; Toksikol.|Sanit. Khim. Plastmass 2, 22-24, (1979)
Repeated dose toxicity: inhalation, IUC4#21/Ch.5.4
National Cancer Institute (NCI) (1979) Bioassay of|o-Toluidine Hydrochloride for possible carcinogenicity.|Technical Report Series No. 153. NIH Publication No.|79-1709.
Method: other: Carcinogenesis bioassay see also freetext TC
Lee KP, Chromey NC, Culick R, Barnes JR, Schneider|AP (1987). Toxicity of N-methyl-2-pyrrolodone (NMP):|Teratogenic, subchronic, and two-year inhalation studies,|Fundam. Appl. Toxicol., 9, 222-235
Degussa AG (2003), unpublished report. Estimation of the|Photodegradation of Diethyl malonate CAS-No.: 105-53-3 by|Quantitative Structure Activity Relationship (QSAR-Method =|Calculation) Degussa AG-Reg-No. 2003-0444-DKB.
Method: other (calculated): AOPWIN (AOP(c)) Program, Version 1.90, Syracuse Research Corporation, Merrill Lane, Syracuse, New York, 13210, U.S.A., 2000
Environmental Agency, Japan (1999a) Unpublished testing|report on toxicity of o-chlorobenzyl chloride to Selenastrum|capricornutum, Test No. 10041, conducted by Japan Food|Research Laboratories.
ACIMA AG. Akute Bakterientoxizitat. Zellvermehrungshemmtest mit Pseudomonas putida. Testsubstanz: Monobutylzinntrichlorid. Code Nr. 8502/1. 22.2.1985.
Eastman Kodak Co. data from 1959 and 1968, NTIS Doc. No.|86860000118, Michrofiche OTS0510265 (1986)
Blaha L, Damborsky J, Nemec M (1998). QSAR for acute toxicity of saturated and unsaturated halogenated aliphatic compounds. Chemosphere 36 (6), 1345-1365.
Exilie, M.P. et al.: Toxicol. Lett., Special Iss. 1, 246|(1980); abstract;|cited in: RIFM database, location no. 7747
Genetic toxicity in vitro, IUC4#74/Ch.5.5
Deneer JW, van Leeuwen CJ, Seinen W, Maas-Diepeveen JL,|Hermens JLM (1988). The Toxicity of Aquatic Pollutants:|QSARs and Mixture Toxicity Studies, Chapt. II. A QSAR study|of the toxicity of nitrobenzene derivatives towards Daphnia|magna, Chlorella pyrenoidosa and Photobacterium phosphoreum.|Dissertation, University of Utrecht.
Method: other: Dutch Standard Organisation NEN 6501 (1980)
Short-term toxicity to aquatic invertebrates, IUC4#110/Ch.4.2
Schulz R, Schwanitz G, Winterhoff H (1982) Investigations on the mutagenic and clastogenic activity of resorcin/cytogenetic findings from different types of human cells. Arzneimittelforschung 32(5):533-536.
Brooke D., Crookes M.J. Quarterman P., Dungey S.: Draft|Environmental Risk Assessment Report: Complex Alkylphenols.|UK Environment Ageny. September 2004
Bringmann, G. 1978. Determination of the biological effect|of water pollutants on protozos. Part II. Bacteriovorous|flagellates (model organism: Entosiphon sulcatum Stein). Z.|Wasser Abwasser Forsch., 11: 210-215.
Monsanto (1983). Coate WB. Acute (LC50) Inhalation Toxicity|Study in Rats - Phosphorus Trichloride. Report HL-82-0136;|21 Nov 1983.
Carpenter CP and Smyth HF, Jr. 1946. Chemical burns of the rabbit cornea. Am J Ophthalmol 29:1363-1372.
Safepharm Laboratories (2002) SPL Project number 1254/041,|EHTG: Determination of vapour pressure.
Method: other (measured): Method A4 specified in Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC).
Vickers (1975) Texaco (Jefferson) Chemical Company,|Austin Reseaerch Laboratory, 18/2/75.
Daniel F., Condie L., Robinson M., Stober J., York R., Olson G. & Wang S. (1990). Comparative Subchronic Toxicity Studies of Three Disinfectants. Journal of the American Water Works Association, October, 61-69.
MITI (Ministry of International Trade and Industry)(1992).|Biodegradation and Bioaccumulation data of Existing|Chemicals Based on the Chemical Substances Control Law|(CSCL). Japan. Chemicals Inspection and Testing Institute|(CITI, ed.); Japan Chemicals Industry Ecology Toxicology and|Information Center 3-97.
Deneer JW, van Leeuwen CJ, Seinen W, Maas-Diepeveen JL,|Hermens JLM (1989) A QSAR study of the toxicity of|nitrobenzene derivatives towards Daphnia magna, Chlorella|pyrenoidosa and Photobacterium phosphoreum. Aquatic|Toxicology 15: 83-98
Method: other: NEN 6502: Determination of chronic toxicity to Daphnia magna (1980)
Long-term toxicity to aquatic invertebrates, IUC4#95/Ch.4.5.2
Schneider P., Pappritz G., Muller-Peddinghaus R., Bauer M., Lehmann H., Ueberberg H., Trautwein G.
Fifteen dogs were administered diets providing 800 mg/kg day for 14 and 38 weeks. An unspecified number of control dogs were included in the study. All dogs were examined clinically at regular intervals. At the end of the experiments the animals were kil
Melting point/freezing point, IUC4#7/Ch.2.1
Ann Arbor Technical Services, Inc.: Hydrolysis of|Chloromethane as a Function of pH Following TSCA Test|Standard 796.3500; sponsored by Methyl Chloride Industry|Association (1989).
Method: F09-03:in general conformance with USEPA TSCA Test standard 796.3500
Hulzebos, E.M. et al., Environ. Toxicol. Chem. 12 (6),|1079-1094 (1993)
Method: other: OECD Guide-line 208 (1984)
Silicic acid, aluminum sodium salt (IUC4 DSN 81)
Morton International, Inc. 2000. Environmental risk assessment of methyltin chlorides from heat stabilizers in PVC. TNO Report No. TNO-MEP-R 2000/080. 3 March 2000.
Hoechst AG. 1985. Unveroeffentlichte Untersuchung [unpublished study] (W 85-546)
Method: other: Daphnien-Kurzzeittest [short term test] DIN 38412 Teil [Part] 11, Bestimmung der Wirkungvon Wasserinhaltsstoffen auf Kleinkrebse [Determination of the effect of water contaminants on small crustacean]
Ciba-Geigy Ltd., Report on the test for acute toxicity of TK|10044 to bluegill, Project No. 840057; 18.5.1984.
Milano JC, Guibourg A, Vernet JL (1988). Evolution non biologique dans l'eau de composes organohalogenes a trois et quatre atomes de carbone: hydrolyse et photolyse. Non biological evolution, in water, of some three- and four-carbon atoms organohalogenated compounds: hydrolysis and photolysis. Water Res. 22 (12), 1553-1562.
Degussa AG, unpublished report, 1993, Mouse Micronucleus Test ip. Degussa Report No. 93-0057-DGT
Toksikologicheskii Ventnik, 4, 39-44(1998)
The Merck Index Online (SM), Feb. 20. 2001
Freitag D, Lay JP and Korte F (1984). Environmental Hazard|Profile - Test Results as Related to Structures and|Translation into the Environment. QSAR Environ. Toxicol.,|111-136.
Heddle, J.A. and Bruce W.R. in: Hiatt, H.H. et al. (eds.):|Origins of Human Cancer, CSH Press, Cold Spring Harbor, NY|(1977); pp. 1549-1557
Deener J. W. et al. Ecotoxicol. Environ. Safety 15, 72-77|(1988)
Method: other: The concept NEN report 6502 (Dutch Standard Organization)
Merck Index (2001). Merck & Co Inc. Whitehouse Station, New|Jersey, USA, 13th Ed., catchword Phosphorus trichloride.
Solubility in organic solvents / fat solubility, IUC4#40/Ch.2.6.1
ACGIH (2001). Formic acid, product information. American|Conference of Governmental Industrial Hygienists,|Cincinnati, Ohio, USA.
Burleigh-Flayer, H.D., Gill, M.W., Strother, D.E., Masten, L.W., McKee, R.H., Tyler, T.R., and T. Gardiner
Szybalski, W.: Ann. NY Acad. Sci 76 (3), 475-489 (1958);|cited in: RIFM database, location no. 3403
Genetic toxicity in vitro, IUC4#95/Ch.5.5
Chibanguza G (1985). Prufung von leichte calc. soda im|hautreiztest am kaninchen. IBR Forschung GmbH, Projekt nr.|1-3-391-85.
EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
Degussa-Huls AG (1994) Determination of the acute |effects of DYNASYLAN HMDS On the swimming behavior |of Daphnia magna (in accordance with EG 92/69/EEC). |Final Report DK 591. Degussa-Huls AG-Nr.: 94 0859 |DGO. 5/26/94.
EnviroTIPS (1984): Chlorine. Environment Canada,|Environmental Protection Service, Ottawa, Ontario.
Method: other: Microorganism toxicity test
Le Curieux F, Nesslany F, Munter T, Kronberg L, Marzin D|(1999) Genotoxic activity of chlorohydroxyfuranones in the|microscale micronucleus test on mouse lymphoma cells and the|unscheduled DNA synthesis assay in rat hepatocytes. Mutagen|14: 457-462
Hisgen (2003), "Epsilon-Caprolactone - Determination of the|acute effect on the swimming ability of the water flea|Daphnia magna Straus", BASF Experimental Toxicology and|Ecology Project No. 03/0034/50/1
Huels AG, 1978, Abschlussbericht GF-108. Bestimmung der|biologischen Abbaubarkeit von Isobutanol im Geschlossenen|Flaschentest (OECD-method 301D), Marl, Germany.
Biodegradation in water: screening tests, IUC4#40/Ch.3.5
Scientific Committee on Consumer Products (SCCP) (2008) As cited in Scientific Committee on Consumer Products Opinion on Resorcinol, COLIPA no. A11 (SCCP/1117/07) dated April 15, 2008.
Bayer AG (1978 b) Benzotrichlorid akute toxikologische|Untersuchungen. Study report No. 7839 dated September 29,|1978
Method: other: single exposure for 0.5, 1.0, 3.0 or 7.0 h
Acute toxicity: inhalation, IUC4#14/Ch.5.1.2
BASF AG (1979 a), Department of Toxicology: "Bericht ueber die Bestimmung der akuten Inhalationstoxizitaet LC50 von i-Butanol bei 4stuendiger Exposition an Sprague-Dawley-Ratten", unpublished report, (78/306), 03.12.1979 as cited in IUCLID.
Acute toxicity: inhalation, IUC4#40/Ch.5.1.2
Leung, H.-W. (1994). Evaluation of the genotoxic potential of alkyleneamines. Mut. Res. 320, 31-43.
Method: other: comparable to OECD guide-line 482
Mortelmans K, Haworth St, Lawlor T, Speck W, Tainer B,|Zeiger E (1986). Salmonella mutagenicity tests: II. Results|from the testing of 270 chemicals. Environ. Mutagen. 8|[Suppl. 7], 1-119.
Method: other: preincubation method according to Haworth, Environ.Mutagen.5[Suppl.1], 3 (1983); preliminary dose setting experiments, S-9 mix from rat and hamster livers, see also freetext ME.
BASF AG, Safety data sheet 3-METHYLBUTEN-2-AL-1, 14.11.2001
Canton JH, Slooff W, Kool HJ, Struys J, Pouw TJM, Wegman|RCC, Piet GJ (1985) Toxicity, Biodegradability and|Accumulation of a Number of Cl/N-Containing Compounds for|Classification and Establishing Water Quality Criteria.|Regulatory Toxicol Pharmacol 5: 123 - 131
Method: other: Analogy with the OECD proposal to short-term toxicity tests performed on fish (Poecilia reticulata) (1979)
Salmonella typhimurium (see freetext TC)
National Institute of Environmental Research (NIER), 2002. Calcium sulfate dihydrate: Combined Repeated Dose Toxicity with the Reproduction/Developmental Toxicity Screening Test (Test No. S506), Tested by LG Life Science/Toxicology Center, Korea
Method: other: OECD TG No. 422 "Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test"
Stangenberg, M. (1975) The influence of the chemical|composition of water on the pike perch (Lucioperca|lucioperca L.) fry from the lake Goplo. Limnologica, 9(3),|421-426.
Salmonella typhimurium TA 97, TA 98, TA 100, TA 102
BASF AG, Analytisches Labor, unveroeffentlichte|Untersuchung, Bericht zu J.Nr. 101025, 10.10.1988
IIT Research Institute. 1990. Acute Dermal Toxicity Study|of Isophthalic Acid in Rabbits. IITRI Project No. L08100,|Study Number 1554.
Hawley. G.G. (ed) (1981). The Condensed Chemical Dictionary.|10th Ed. Van Nostrand Reinhold, New York, p. 847.
BASF AG, Department of Toxicology, Bericht über die|gewerbetoxikologische Grundprüfung, unpublished report|(78/452), 22 Aug. 1979
Liu, Wang, Chen, Li, Yu (1996): Bull. Environ. Contam.|Toxicol. 57(3), 421-425
Short-term toxicity to fish, IUC4#31/Ch.4.1
NTP (1982) National Toxicology Program, Carcinogenesis|bioassay of 11 aminoundecanoïc acid in F 344 rats and B6C3F1|mice. Technical report series N°216.
The nine volume 2nd edition of the CRC Handbook of Data on|Organic Compounds
Hermens, J., H. Canton, N. Steyger and R. wegman (1984):|Joint effects of a mixture of 14 chemicals on mortality and|inhibition of reproduction of Daphnia magna, Aquatic|Toxicology, (5): 315 - 322.
reduction of the maximum density (yield) of Chlorella pyrenoidosa
Type of cell used: Chinese hamster lung(CHL/IU) cells
Vertraete W, Claes M, De Backere R, Voets JP (1974). The|influence of Crotodur, Isodur and Nitroform on some soil|microbiological populations and processes. Z.|Pflanzenernaehrung Bodenkunde 135 (3), 258-266.
Toxicity to soil microorganisms, IUC4#3/Ch.4.4
MHW, Japan (1997) Ministry of Health and Welfare, Toxicity Testing Reports of Environmental Chemicals, Vol 5 (158-159)
CIBA-GEIGY Ltd. 1981. Report on Acute Oral LD50 in the Rat of TK 11638. Project No.: 811185. 03.11.1981.
Method: other: similar to OECD Guideline 401
BASF AG, 2003, Product Safety, SRC AOP v1.90, data|assessment, 01 July 2003
Method: other (calculated): using SRC AOP v1.90
Phototransformation in air, IUC4#10/Ch.3.1.1
Didenko G.G., Gupalovic T.D., Petrovskaja O.G.: Possible|carcinogenic properties of isobutylidene diurea. Vopr.|Pitan. 37(2), 72-73, 1979 (in Russian)
Kimmerle G (1968). Isophorondiisocyanat - toxikologische Untersuchungen. Report 908 (unpublished). Bayer AG (Wuppertal).
Ministry of Economy, Trade and Industry (METI, former MITI),|Japan (1998) unpublished data, conducted by Chemicals|Evaluation and Research Institute (CERI), Japan
Method: other: 20 rats, no further information
Dow Corning Corporation Internal Report Number|1977-I0005-524
Patty FA (1967) Industrial Hygiene and Toxicology. 2nd rev.|ed., Vol. II, Interscience Publ., New York, p. 1975-1979
BASF AG, Material Safety Data Sheet, Butyl acrylate, 01-30-2002
Toxicity to microorganisms, IUC4#13/Ch.4.4
Method: other: according Fox 1982, McMillan and Fox 1979
Zacherl, B. and Amberger, A. (1990). Fertilizer Research 22,|137-139
BASF AG, 1989, Analytical Laboratory, Bestimmung des|Verteilungskoeffizienten log Pow der Prüfsubstanz in|1-Octanol/Wasser bei 25°C, unpublished study, J. No. |106288/13, 03 May 1989
Method: other (measured): according to EEC Directive 79/831, Annex V, Part A: Methods for Determination of Physical-Chemical-Properties.
Matsui et al. (1975): Prog. Water Technol., Vol. 7,|Nos. 3/4, 645-659
Method: other: activated sludge simulation test
Nakamura, S. et al.: Mutat. Res. 192, 239-246 (1987), No information
Genetic toxicity in vitro, IUC4#143/Ch.5.5
Kiplinger, G.R., 1994. Acute Oral Toxicity Comparison Study|of Microencapsulated Methyl Bromide and Liquid Methyl|Bromide in Albino Rats. Unpublished report from WIL Research|Laboratories, Project No. WIL-49011.
Method: other: 81-1 (EPA FIFRA Pesticide Assessment Guidelines, Subdivision F: Hazard Evaluation: Human and Domestic Animals, Section 81-1) and the TSCA Health Effects Test Guidelines, 40 CFR 798.1175.
BASF AG (2007) Department of Experimental Toxicology and|Ecology. Natriumformiat (sodium formate) - Acute dermal|toxcity study in rats. Study No. 11A0123/0310833|(unpublished), dated January 15, 2007
Kamata et al., 1997, The Journal of Toxicological Sciences,|22, 239-254, No information
Repeated dose toxicity: inhalation, IUC4#20/Ch.5.4
MacKenzie, K. and M. Schoffman (1958) U.S. Patent|US2866800.
Method: other: in general conformance with OECD 478
Genetic toxicity in vivo, IUC4#11/Ch.5.6
Lanxess (2005). Material Safety Data Sheet of|Dicyclohexylamine. No. 019260/15, 2005-02-08.
Powell, D.E. (2003) Fate, distribution, and transport of|ethyltriacetoxysilane (CAS 17689-77-9) in the environment as|predicted by fugacity modeling. Silicones Environmental,|Health and Safety Council (SEHSC), final report, Project|Number 01-014, August 2003.
USEPA. 2000. MPBPWIN. Version 1.41. Estimation Programs Interface (EPI) Suite. Office of Pollution Prevention Toxics (OPPTS) and Syracuse Research Corporation.
Method: other (calculated): MPBPWIN v1.41
Degussa AG (1979). Department of Toxicology. Akute Toxizität|an der Ratte nach oraler Verabreichung. Summary, dated|February 07. 1979, with attached study report summary.
Degussa AG (2003). Unpublished calculation using standard|methods / equations
Method: other: calculation with BCFWIN v2.14 as integrated in EPIWIN v3.10, Syracuse Research Center / U.S. EPA
Amacher, D.E. & Turner, G.N., Prog. Mutat. Res. 5, 487-496|(1985)
Sasaki, M., Sugimura, K., Yoshida, M. et al. (1980):|Cytogenetic effects of 60 chemicals on cultured human and|Chinese hamster cells. La Kromosomo, 20, 574-584.
SPARC on line calculator|(http://ibmlc2.chem.uga.edu/sparc/index.cfm)
Gaffney PE and Ingols RS (1961). Nitrate as the nitrogen|source in BOD dilution water. Water & Sewage Works, March|1961, 91-95.
Method: other: "Standard methods for the Examination of Water, Sewage, and Industrial Wastes", 11th ed. (U.S. method)
Barbin, A. G. et al (1978) Mutation Research 53, 150.
CIBA-GEIGY, Ltd. 1988. Investigation of the Potential for Covalent Binding of DOTC to Rat Liver and Thymus DNA. Report Nr.: GU24-07881. 8.8.1988.
Hillbom M.E. et al.: Japan J. Stud. Alcohol., 9, 101-108, (1974); cited in WHO: Environmental Health Criteria 65, pp. 93 ff., (1987), as cited in IUCLID.
Repeated dose toxicity: oral, IUC4#70/Ch.5.4
BASF AG, Department of Ecology, Bakterienwachstumshemmtest,|unpublished study, 01/88/0550, 17 Dec. 1990
Method: other: Pseudomonas Cell-Multiplication Inhibition Assay according to DIN 38412, part 8 (Draft; Bestimmung der Hemmwirkung von Wasserinhaltsstoffen auf Bakterien)
Zijlstra, J.A. and Vogel, E.W.: Mutat. Res. 198, 73-83|(1988), No information
Method: other: in vivo gene mutations - eukaryotes (non-mammalian/Drosophila)
Genetic toxicity in vivo, IUC4#23/Ch.5.6
SCR PhysProp Database. 2001.|htt/://esc.syrres.com/interkow/webprop.exe?CAS=528-44-9
Laughlin, R.B. Jr., R.B. Johannesen, W. French, H. Guard, and F.E. Brinchman. 1985. Structure-activity relationship for organotin compounds. Environmental Toxicology and Chemistry. 4:343-351.
MacKellar, D.G.: Food and Drug Research Lab., Report No.|ICD/T-76-16, January 30 (1976) at the request of FMC
Acute toxicity: dermal, IUC4#20/Ch.5.1.3
Dow Corning Corporation (1958) Report No. 1958-I0030-1713.
BASF AG (2005). Safety data sheet according to 91/155/EEC,|N-Methylpyrrolidon dest., revised 04 Feb 2005.
Haruki, M. (1999) Effects of deicing materials on plants and|soil animals in north Japan. Cold Region Technol. Conf.|1999, 824-830. (in Japanese)
Toxicity to terrestrial plants, IUC4#70/Ch.4.6.2
Martin, C.N. & Campbell, J., Prog. Mutat. Res. 5, 375-379|(1985)
OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
Allyl Alcohol Consortium (2005c) AOPWIN v1.91 Calculations,|Unpublished Data
Method: other (calculated): AOPWIN v1.91
Helleday T, Tuomine KL, Bergman A, Jenssen D (1999). Brominated flame retardants induce intragenic recombination in mamamalian cells. Mutation research Vol.439 2, p. 137-147.
Carpenter C.P. et al. (1974). Tox. Appl. Pharm., 28, p. 313-319.
Method: other: acc. to Smyth, H.F. et al., Amer. Ind. Hyg. Assoc., 23, 95-107, 1962
Okada et al. (1985): Sensitization test of Naphthol AS on|guinea pigs. Nippon Hifuka Gakkai Zasshi, 95,|1487-1489 (in Japanese)
Method: other: OECD guideline 406 with modifications
Deneer JW, Sinnige TL, Seinen W, Hermens JLM (1987).|Quantitative structure-activity relationships for the|toxicita and bioconcentration factor of nitrobenzene|derivates towards the guppy (Poecilia reticulata). Aquatic|Toxicol. 10, 115-129.
Chem Systems (1997). Routes to Pyrrolidones 94/95S1,|technical leaflet, Chem Systems Inc., Tarrytown, New York,|USA.
Melting point/freezing point, IUC4#24/Ch.2.1
Canton HJ, Adema DMM, de Zwart D (1984). Onderzoek naar een|geschikte cominatie toetsmethoden ter bepaling van de|aquatische toxiciteit van milieugevaarlijke stoffen, Bijlage|1: Onderzoek naar de bruikbaarheid van een drietal|eierleggende vissoorten in routine toxiciteitsonderzoek|(Rapport nr.: C1 81/100A, RIVM 668114 002)
BASF AG (1981). Department of Toxicology. The Acute Oral Toxicity (LD50) and Neurotoxic Effects of TPP to the Domestic Hen, Internal No. 79/355, study performed by Huntingdon Research Centre, Unpublished Report, HRC Report No. BSF 329/81403, 24 July 1981.
Method: other: US EPA 163, 81-7 "Acute delayed neurotoxicity study", Fed. Reg. , Part II, pp. 37362-37363, 22 Aug. 1978
BioReliance (2008) Mouse Bone Marrow Erythrocyte Micronucleus Test Following Intraperitoneal Administration of OS-2000 (Draft report). Study Number AC14PM.123.BTL.
Daubert, T.E. and R.P. Danner. 1989. Physical and Thermodynamic Properties of Pure Chemicals. Data Compilation. Hemisphere Publishing Corp. New York, NY.
Patty, F.A. 1982. Industrial Hygiene and Toxicology, 3rd|ed., New York, Chichester, Brisbane, Toronto, Singapore,|Wiley-Interscience. IIC: 4571-4578. As cited in World Health|Organization (WHO). 1987. Environmental Health Criteria 65:|Butanols - Four Isomers: 1-Butanol 2-Butanol tert-Butanol|Isobutanol. WHO.
Devillers J, Chezeau A, Poulsen V and Thybaud E. 2003. Effects of glycol ethers on the reproduction of Ceriodaphnia dubia. Chemosphere 50: 373-376.
LeCurieux, F. et al.: Mutat. Res. 319, 223-236 (1993), No information
Genetic toxicity in vitro, IUC4#138/Ch.5.5
Ciba Speciality Chemicals Inc (1998). RCC Cytotest Cell|Research GmbH Project 619900. Salmonella typhimurium and|Escherichia coli reverse mutation assay with FAT 65´019/I.|Study No. 619900 reported from RCC Cytotest Cell Research|GmbH to Ciba-Geigy AG dated 1998-12-23.
Pyatnitskaya LV (1973): Irritating action of beta-naphthol.|Gig Sanit 37(12), 97-99 (in Russian)
E.I. du Pont de Nemours and Company (1987). Mouse sensory irritation. NTIS/OTS Microfiche 0514930, Doc 86-870001028.
Marhold, J.V. (1972) Institut Pro Vychovu Vedoucicen|Pracovniku Chemickeho Prumyclu, Praha, Czechoslovakia, p.|66.
Ministry of Health and Welfare: Japan (1997) Toxicity|Testing Reports of Environmental Chemicals 5, 697-725.
US Environmental Protection Agency (1978). In-Depth Studies|on Health and Environmental Impact of Selected Water|Pollutants. Contract No.68-01-4646, US EPA 9.
Toxicity to aquatic algae and cyanobacteria, IUC4#28/Ch.4.3
Bayer AG (2003). alpha,alpha,alpha-Trichlorotoluene, CAS-No.|98-07-7. Calculation of |- Log Octanol-Water Partition Coefficient with SRC-KOWWIN|v1.66, 2000.|- Indirect Photodegradation with SRC-AOPWIN v1.90, 2000.
Method: other (calculated): with SRC-KOWWIN v1.66, 2000
Toksikologiya Novykh Promyshlennykh Khimicheskikh|Veshchestv. (1979). Toxicology of New Industrial Chemical|Substances. (Izdatel'stvo Meditsina, Moscow USSR) No.1-1961,|15, 116.
Molodkina NN (1974). Comparative toxicity of the chloride|compounds of phosphorus (POCl3, PCl3, PCl5) in single and|repeated exposures. Toksikologiya Novykh Promyshelennykh|Khimicheskikh Veshchestv 13, 107-114.
Dow Corning Corporation Internal Report Number|1963-I0065-1167-02
Ashford's Dictionary of Industrial Chemicals (2001), 2nd|Edition, p. 634. Wavelength Publicaitons.
Capuzzo, J.M., Davidson, J.A., Lawrence, S.A., Libini, M.|(1977): The differential effects of free and combined|chlorine on juvenile marine fish. Estua. Coast. Mar. Scie.,|5, 733-741.
Short-term toxicity to fish, IUC4#24/Ch.4.1
INERIS-L.E.T.E. Study No. 95017 (1996). Test substance: Chlorine Dioxide. Final Report. Study of acute toxicity of chlorine dioxide administered to rats by vapour inhalation. Determination of the 50% lethal concentration (LC50 / 4 hours).
Landsteiner K and Jacobs J (1935) Studies on the|sensitization of animals with simple chemical compounds. J|Exp Med 61: 643-657
Simmon, V.F., Kauhanen, K., Tardiff, R.G. 1977. Mutagenic|activity of chemicals identified in drinking water. In:|Scott D, Bridges BA, & Sobels FH, ed. Progress in genetic|toxicology. Amsterdam, Elsevier/ North-Holland Biomedical|Press, pp 249-258.
Dasgupta PK, Duvall TR (1980) Study of bisulfite and|metabisulfite aerosol generation systems. Am Ind Hyg Assoc J|41: 666-671
Method: other: measurement of depression of respiratory rate
USEPA. 2000. BCFWIN. Version 2.15. BCF Estimate from Log Kow. EPIWIN (Estimation Program Interface for Windows). Version 3.12. Office of Pollution Prevention Toxics (OPPTS) and Syracuse Research Corporation.
Method: other: (calculated) BCFWIN v2.15
Escherichia coli WP2 (repair proficient), WP67 (uvrA- polA-), CM871 (uvrA-, recA-, lexA-)
Von Oettingen W.F. The aliphatic alcohols, their toxicity|and potential dangers in relation to their chemical|constitution and their fate in metabolism. U.S. Public|Health Service., Public Health Bulletin., No. 281.|U.S.Government Printing Office., Washington D.C. 1943.
BASF (1981) Report on the study of Mucochlorsaeure techn.|trocken (80/408) in the Ames test. BASF AG, Department of|Toxicology, 14.07.1981 (unpublished data)
Method: other: in accordance with Ames B.N. et al.: Proc.Nat.Acad.Sci USA, 70, 70, 2281-2285 (1973) and Ames B.N. et al.: Mut.Reg., 31, 347-364 (1975)
Salmonella typhimurium TA1538, TA1537, TA1535, TA98 and TA100
Long-term toxicity to fish, IUC4#2/Ch.4.5.1
Hine C. Comparative toxicity of synthetic and natural|glycerin, Arch Ind Hyg Occup Med 7:282-291, 1953 (47)
Johnson PR (1992). Fish toxicity of neoprene intermediates and additives with cover letter dated 101592. EPA/OTS Doc#88-920010291, NTIS Order No.: NTIS/OTS0571687.
Eustis, S.L., Haber, S.B., Drew, R.T., Yang, R.S.H. 1988.|Toxicology and pathology of methyl bromide in F344 rats and|B6C3F1 mice following repeated inhalation exposure, Fund.|Appl. Toxicol. 11:594-610.
Toxicity to reproduction, IUC4#6/Ch.5.8.1
Huntingdon Research Centre Ltd. (1990) Dynasylan IBTEO:|Acute inhalation toxicity study in rats 4-hour exposure.|Report DNN 53/90393. Degussa-Huls AG-Nr.: 90-0219-DGT May|25, 1990
Method: other: comparable to OECD TG 403
Cuthbert JA and Carr SMA (1985). 12 alkaline silicates: a|skin irritation investigation. Inveresk Research|International, Report no. 3325.
Yoshioka, Y. et al., Testing for the Toxicity of Chemicals|with Tetrahymena pyriformis, The Science of the Total|Environment, 43, 149-157 (1985)
Wickramarathne, G.A. de S.: Teratogen, Carcinogen. Mutagen.|7 (1), 73-83 (1987);|cited in: RIFM database, location no. 5057
Method: Chernoff-Kavlok teratogenicity screening test
Developmental toxicity / teratogenicity, IUC4#27/Ch.5.8.2
Andersen, K.E. and Volund, A.: Report for the Nordic|Chemicals Group, Nordiske Seminar og Arbejdsrapporter, 570|(1993), No information
Short-term toxicity to fish, IUC4#54/Ch.4.1
Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger|E, 1986 Salmonella Mutagenicity Tests: II Results from the|Testing of 270 Chemicals. Environ Mutagen. 8(Suppl 7):|1-119.
Serjeant, E.P. et al. (1979). Ionisation constants of |organic acids in aqueous solution. IUPAC Chemical Data |Series N. 23. New York, NY, Pergamon Press, p. 989.
Smyth HF, Carpenter CC, Weil CS, Pozzani UC, Striegel JA and|Nycum JS (1969). Range-Finding Toxicity Data: List VII. Am.|Ind. Hyg. Assoc. J. 30, 470-476.
Method: other: as described by Smyth et al., Amer. Ind. Hyg. Assoc. J. 23, 95-107
CIBA-GEIGY, Ltd. 1988. Report on the Alga, Growth Inhibition Test with TK 10976. Project No.: 884108. 16 March 1988.
SafePharm Laboratories (2007)|Vinyltris(methylethylketoximino)silane (CAS No. 2224-33-1):|Characterisation and Determination of Melting Point/Melting|Range and Boiling Point. SPL Project Number 2383/0009.
Method: other: calculated using OECD TG 104
Riess G (2002). Phosphorus compounds, inorganic. 2.|Phosphorus halogen compounds. In: Ullmann´s Encyclopedia of|Industrial Chemistry (electronic version). Wiley-VCH Verlag|GmbH & Co. KGaA.
Flaningam O.L. and A.L. Smith (1994) Dow|Corning Corporation, Report No. 1994-I0000-39053.
DeSerres FJ, Ashby J (1981) Evaluation of short-term tests|for cancerogens. Progress Mutation Research 1: 1-827
Djalali-Behzad, G., Hussain, S., Ostermann-Golker, S.,|Segerbaeck, D. 1981. Estimation of genetic risks of|alkylating agents. VI. Exposure of mice and bacteria to|methyl bromide. Mutat. Res., 84: 1-9.
Nakai Y, Hirabayshi K, Takahashi Y, Miura D, Kasahara Y,|Morita K, Izawa Y (1994) The genetic toxicology of|o-toluidine with special reference to its non-clastogenicity|in vivo. MMS Com 2: 99-108
Method: other: alkaline elution technique as described Stout and Becker, 1982, Analytical Biochemistry 127, 302-307,see freetext ME
Genetic toxicity in vitro, IUC4#118/Ch.5.5
Shlomi, E.R. et al., Microb. Ecol. 4, 249-261 (1978)
Method: other: anaerobic degradation, static, parameter: gasproduction by GC, 39degree C, pH 6.7
Method: other: Federal Register of August 12, 1961 pages 7333-7341
ETAD (2000). Turck PA. Prenatal developmental toxicity study|via oral gavage to New Zealand White rabbits. MPI Research|Laboratory Study Identification No. 795-004 dated|2000-01-27.
Beilstein (2003). Handbook Register Number: 605923; Entry|date: 1988/11/28; Update date: 2003-01-18.
Fluck, E. R. et al.: Chem.-Biol. Interactions 15, 219-231|(1976)
Kawachi T et al. (1980): Cooperative Programme on Short-Term|Assays for Carcinogenicity in Japan. IARC Sci Publ 27,|323-330
IPC-Environmental Health Criteria 112, p. 40, Tri-n-butyl phosphate, WHO, Geneva 1991
Genetic toxicity in vitro, IUC4#36/Ch.5.5
Thyssen, J.: Bayer AG data, short report, 2. 1. 1979
Skin irritation / corrosion, IUC4#13/Ch.5.2.1
Fiedler H, Hutzinger O, Giesy JP (1990) Utility of the QSAR|Modeling System for Predicting the Toxicity of Substances on|the European Inventory of Existing Commercial Chemicals.|Toxicol Environ Chem 28: 167 - 188
McMahon RE, Cline JC, Thompson CZ (1979). Assay of 855 test|chemicals in ten tester strains using a new modification of|Ames test for bacterial mutagens. Cancer Res. 39, 682-693.
Lemke AE (1983). Interlaboratory comparison of continuous|flow, early life stage testing with fathead minnows. U.S.|EPA 600/3-84-005, NTIS PB 84-129493.
Method: other: Flow-Through Early Life Stage Test, US EPA proposal
Long-term toxicity to fish, IUC4#40/Ch.4.5.1
Rusch, G.M. et al.: Toxicol. Appl. Pharmacol. 68, 329-343|(1983), No information
Zeiger E et al.: Salmonella Mutagenicity Tests: III. Results|from the Testing of 255 Chemicals. Environ. Mutag. 9:|Supplement 9, 1-110 (1987)
Method: other: preincubation according to Haworth et el. (1983)
Beilstein (2003). Handbook Registry Number: 773917,|Dicyclohexylamine, Last Update: 2003-01-18.
IRDC (1973) Primary Skin Irritation and Corrosive Hazard|Test in Albino Rabbits. International Research and|Development Corporation (IRDC). Study #: 328-004. Study|Date: October 31, 1973.
Method: other: Federal Hazardous Substances Act, Chapter II, Title 16 CFR, pre-dates GLP
Degussa AG, Safety Data Sheet: Ammonium persulphate|(13-09-2000), 2000.
Salmonella typhimurium TA 100, TA 1535, TA 1537, TA 1538, TA 98, Escherichia coli WP2uvrA
Smyth, H.F., C.P. Carpenter, C.S. Weil and Pozzani, U.C.
The vapor (approaching saturation) was produced when dried air was passed through a fritted disc gas washing bottle. The resultant concentrated vapours were flushed into a 9-liter dessicator that served as an inhalation chamber for six rats. Nominal co
NTP (1983) National Toxicology Program. Fiscal year 1983|annual plan, page 82
Life Science Research-RTC (1989): Unpublished Study.|Beta-Naphthol. 4 Week oral Toxicity Study in Rats followed|by a 4 week recovery period. Rep. No.212-0-197-002/T/043/89|(HOE 89.1882), 16 Nov 1989
Method: other: similar to OECD Guide-line 407 (1981)
BASF AG (1988). Department of Ecology. Algae test report,|project No. 2/0290/88, 09 Sep 1988, unpublished.
Method: other: closely following German Industrial Standard DIN 38412, Part 9
Monsanto Chemical Co. (1987) unpublished study Project MSL|No. 6346 1/87. Cited in letter from BGVV 06.05.1996
Haruki, M., Tokura, S. and Ueno, Y. (1997) Environmental|effects of deicers in Hokkaido, Japan. Proc. Cold Region|Technol. Conf. 1997, 725-730. (in Japanese)
Toxicity to terrestrial plants, IUC4#50/Ch.4.6.2
Juhnke I and Luedemann D (1978). Ergebnisse der Untersuchung|von 200 chemischen Verbindungen auf akute Fischtoxizitaet|mit dem Goldorfentest. Z. Wasser- Abwasser Forsch. 11 (5),|161-164.
BASF AG (1989). Department of Ecology, unpublished data, project No. 1035/88, 30 Oct 1989
Method: other: following German Industrial Standard DIN 38412 Part 9
Garner RC (1985) Summary Report on the performance of gene|mutation assays in mammalian cells in culture. Prog Mut Res|5: 85-94
Method: other: according Clive et al., 1979, Mutation Res. 59, 61-108
Huels AG (1996d). Bestimmung der Auswirkungen von Isophoron|auf das Wachstum von Scenedesmus subspicatus, Report No.|AW-146 (unpublished).
Method: other: Growth Inhibition Test according to a proposal of the Umweltbundesamt, Germany
SHOWA DENKO K.K. (2003). Material Safety Data Sheet, Allyl|Alcohol (AAL, No. OC-001)
Method: other: cell transformation assay
George Washington University (1951) The Toxicity, Mechanism of Action, and Metabolism of Hydroquinone with Attachment EPA Doc. No. 40-5169110, Fiche No. OTS0517910 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Hoechst AG (1981) Unveröffentl. Unters. Ber. 81.0198 Unpublished investigation.
Method: other: Internal guideline for Hoechst AG
Short-term toxicity to fish, IUC4#18/Ch.4.1
Sun, Ying; Chen, Huiping; Kelly, Jeffrey D.; Eldred, Donald|V.; Reiter, Michael R., "Determination of the Approximate|Molecular Weight of Alkoxysilane Hydrolysis Products in|Gastric Juice Simulant-Memo Report Submitted to the|Silicones Environmental, Health and Safety Council of North|America (SEHSC)"; Dow Corning Corporation Technical Report|No. 2001-I0000-50783, 2001.
Savina, V.P. and Anisimov, B.V. 1987. Kosm. Biol. Aviakosm.|Med. 21:79. Cited in BIBRA (1993)
Reported in Du Pont - Haskell Laboratory - Internal DMAC|Review, Oct. 1988 from Horn H.J., Hazelton Laboratories,|Unpublished Summary of Data, 7/20/59.
Morigami S, Nisimura I (1940) Experimental studies on|aniline bladder tumors. Gann Jpn J Cancer Res 34, 146-147;|cited Toxikolog.-arbeitsmed. Begruendung von MAK-Werten, VCH|(1986)
Richardson LT (1968) Selective Vapor Phase Activity of|Chloronitro- and Chlorobenzenes in Soil. Phytopathology 58:|316 - 322
Toxicity to soil microorganisms, IUC4#9/Ch.4.4
Cosma, G.N. and Marchok, A.C.: J. Cell. Biol. 103, 173A|(1986); abstract no. 640, No information
Genetic toxicity in vitro, IUC4#207/Ch.5.5
Budavari, S. (ed.): The Merck Index - An Encyclopedia of|Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ,|Merck and Co., Inc., No. 510(2001)
Meinema, H.A., T. Berger-Weirsma, G. Versluis-de Haan, and E.C. Gevers. 1978. Environ. Sci. Technol. 12:288. IN The Handbook of Environmental Chemistry. 1990. O. Hutzinger (ed.). Vol. 3, Part E. Anthropogenic Compounds. Springer-Verlag. Berlin, Germany.
FMC Corporation, Acute toxicity of ammonium persulfate to|grass shrimp (Palaemonetes pugio), Study no. I92-1249, 1993|.
EPA OPP 72-3 (Estuarine/Marine Fish, Mollusk, or Shrimp Acute Toxicity Test)
Celanese GmbH (1997): EG-Sicherheitsdatenblatt Natriumsulfit|wasserfrei (10.07.1997)
RTECS, update 8912: Gig. Truda i Prof. Zabol. 27(5), 60|(1983)
Silicic acid, sodium salt (IUC4 DSN 147)
Hill Top Research, Inc. 1971. Acute toxicity and irritation studies on sample TM-181. Report: VA-73. Study conducted for Cincinnati Milacron Chemicals, Inc. 16.3.1971.
Method: other: Federal Hazardous Substances Act
Reference: Reported in Du Pont - Haskell Laboratory - |Internal DMAC Review, Oct. 1988 from Weiss L.R. and R.A.|Orzel (1967), Toxicol. Appl. Pharmacol., 11:546-557.
Kurokawa, Y. et al., Studies on the promoting and complete|carcinogenic activities of some oxidizing chemicals in skin|carcinogenesis. Cancer Letters, vol. 24, 299 - 304 (1984).
EPIWIN (Syracuse Research Corporation Calculated) values,|EPA, 2001
BASF AG, safety data sheet isovaleraldehyde, 16.03.1999
Union Carbide (1968). Cited in: Water quality|characteristics of hazardous materials (1979). Vol 1-4.
Rost E, Franz F (1913) Vergleichende Untersuchung der|pharmakologischen Wirkungen der organisch gebundenen|schwefligen Säuren und des neutralen schwefligsauren|Natriums. Arb Kaiserl Gesundheitsamt 43: 187-303 (In German)
EPISUITE v.3.10, U.S. Environmental Protection Agency (2000)
Method: other (calculation): Calculated using EPISUITE v.3.10 and PCKOCWIN v.1.66 using structural features of the molecule
Adsorption / desorption, IUC4#2/Ch.3.3.2
Lheritier, M. Hazelton France (1992). Test to Evaluate the|Acute Toxicity Following a Single Oral Administration (LD50)|in the Rat. Report No. 203308. Study conducted for Wacker|Chemie, GmbH, 4 August, 1992.
Hasegawa R, Nakaji Y, Kurokawa Y, Tobe M (1989). Acute|toxicity tests on 113 environmental chemicals. Sci. Rep.|Res. Inst. Tohoku Univ. -C, 36, 10-16.
Method: other: calculation of LD50 according to Litchfield and Wilcoxon (1949)
BUA (1987). GDCh-Advisory Committee on Existing Chemicals of|Environmental Relevance (BUA) Report 12, Dinitrotoluenes,|VCH Verlagsgesellschaft, Weinheim.
Smith, A.M., Rigler, E., Kwok, E.S.C. and R. Atkinson, |1996, Kinetics and products of the gas-phase reactions of|6-Methyl-5-hepten-2-one and trans-cinnamaldehyde with OH and|NO3 Radicals and O3 at 296+/-2K, Environ. Sci. Technol. 30,|1781-1785
Hoels-Herpertz (1987) Mutation Research 182:283-284.
Genetic toxicity in vitro, IUC4#24/Ch.5.5
Method: other: Calculated using EPISUITE v.3.10 and BCFWIN v.2.14 with a log Kow of 0.79
Cassella Aktiengesellschaft (1995). Determination of the|water solubility of tungsten carbide, Report No. B 034/94.
Method: other: Directive 92/69/EEC, A.6, comparable to OECD TG 105
Subchronic inhalation toxicity - 90-day study with HCFC-124|in rats, E.I. du Pont de Nemours and Co., Haskell Laboratory|for Toxicology and Industrial Medicine, USA, Haskell|Laboratory Report No 79-91, 1991||Malley, L.A, Carakostas, M., Elliott, G.S., Alvarez, L.,|Schroeder, R.E., Frame, S.R., Van Pelt, C. Tromchimowicz,|H.J. and Rusch, G.M. Subchronic toxicity and teratogenicity|of 2-Chloro-1,2,2,2-tetrafluoroethane (HCFC-124), Fundam.|Appl. Toxicol., Vol 32, 11-22, 1996
CIBA-GEIGY, Ltd. 1986. Final Report. TK 11638/1. Acute Oral Toxicity in the Rat. GU Project No. 86013. 17.11.1986.
Chiou CT and Schmedding DW (1982). Partitioning of organic|compounds in octanol-water systems. Environ.Sci.Technol. 16,|4-10.
Method: other: see below test conditions
Degussa AG, unpublished, Report: Degussa AG - US-IT-Nr.:|79-0017-DKT (1979)
Dave, G. et al., J. Chem. Technol. Biotechnol. 29 (4),|249-257 (1979)
Short-term toxicity to fish, IUC4#120/Ch.4.1
ATOFINA Chemicals, Inc. Material Safety Data Sheet. Monobutyltin trichloride. Revision 2. Issued 16.06.2000.
Amoco Corporation. 1997. Material Safety Data Sheet|(www.vetmed.ucdavis.edu/msds/mf/Amoco/files/01260000.html)
Wu H, Chen Y, Zhang X, Zhang Y (2000). Effect of|dinitrotoluene (DNT) on immune function of red cells in|rats. Gongye Weisheng Yu Zhiyebing 26, 88-89.
Bayer AG (1978). Bomhard E and Loeser E. Blankophor BBH|(Farbsaeure). Chronische toxikologische Untersuchungen an|Ratten (Fuetterungsversuch ueber 2 Jahre). Study report No.|7396 dated 1978-03-23.
Monsanto Study No. XX-87-9007 (B.F. Goodrich report) as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Genetic toxicity in vitro, IUC4#50/Ch.5.5
E. coli WP2; WP67 uvrA polA; CM871 uvrA recA lexA
METI Japan (1996) Ministry of Economy, Trade and Industry (former MITI), test report conducted by Chemicals evaluation and Research Institute (CERI, Japan) Test No. 81219K
Method: other: Chromosome Aberration Test, BrdUrd-labelling technique
Genetic toxicity in vitro, IUC4#263/Ch.5.5
Method: other: not specified (range finding study)
BASF AG (1979 b), Department of Toxicology: "Bericht ueber die Pruefung der akuten Inhalationsgefahr (akutes|Inhalationsrisiko) von i-Butanol, Prod Nr. 00902 an Sprague-Dawley-Ratten", unpublished report, (78/306), 03.12.1979 BASF AG, Department of Toxicology: Unpublished report (77/668), 10.27.1978 as cited in IUCLID.
Method: T06-03:exposure according to method of Smyth, et al., Am. Ind. Hyg. Assoc. J. 23:95-107, 1962
Acute toxicity: inhalation, IUC4#80/Ch.5.1.2
Salmonella typhimurium TA1535, TA100, TA1537, TA98
Inversk Resarch International(IRI).(1991a), Primary skin|irritation test in rabbits. Report No.6915, Unpublished|report
Schnuch, A. and Geier, J. (1995), Epikutantestung mit dem|DKG-Analblock, Dermatosen 43, 81-82
Yoshimura H, Katayama H, Takemoto K, Matsushita S (1979)|Experimental lung tumors induced by exposure to|benzotrichloride (2). Proc of Japan Assoc of Ind Health 332|- 333. TSCA 8e Submission 8EHQ-0980-0360 Document No.|86-8000116, Washington, DC: Office of Toxic Substances, U.S.|Environmental Protection Agency
Method: other: carcinogenicity induced by repeated inhalation
Repeated dose toxicity: inhalation, IUC4#10/Ch.5.4
Method: other: according to principles of Draize test
triisooctyl 2,2',2''-[(octylstannylidyne)tris(thio)]triacetate (IUC4 DSN 29)
Springborn Smithers Laboratories (2004) Trimethoxysilane -|Toxicity to the Freshwater Green Algae Pseudokirchneriella|subcapitata. Wareham, MA. Report No. 12023.6143.
Witco Corporation (1996) A-166, Material Safety Data |Sheet Number 03921, 01/22/96.
Eastin WC,Haseman JK, Mahler JF, Bucher JR (1998) The National Toxicology Program Evaluation of Genetically Altered Mice as Predictive Models for Identifying Carcinogens. Toxicology Pathology 26(4):461-473.
Crutzen, P.J., Krasnec, J.P. and McAfee:. J. Geophys. Res.|83:345-363 (1978).
Method: other (calculated): Arrhenius equation
Phototransformation in air, IUC4#6/Ch.3.1.1
Hamasaki, T., T. Sato, H. Nagase, and H. Kito. 1992. The genotoxicity of organotin compounds in SOS chromotest and rec-assay. Mutation Research. 280:195-203.
Karegoudar, Pujar. (1984): J. Karnatak Univ. Sci. 29, 69-73;|cited in: Chem. Abstr. 104, 39094z (1986)
Bosch, Vaerenbergh van (1978): Doc.-Eur. Sewage Refuse Symp.|EAS, 4th, 272-286; Abwassertech.
Method: other: slightly modified OECD system (confirmatory Test Procedure)
Monsanto (1977) Acute (96-hour) Toxicity of Santoflex 13 to|Rainbow trout and Bluegill. Unpublished study No. BN-76-256
Short-term toxicity to fish, IUC4#210/Ch.4.1
Svobodova, Z., Machova, J., Faina, R., Stanek, P.,|Schneedorfer, J. (1983). Acute Toxicity of Peroxidisulphates|to Aquatic Organisms. Buletin VURH Vodnany, 4, 17-24.
MITI Japan (1992). Biodegradation and bioaccumulation data |of existing chemicals based on the CSCL Japan, ed. by |chemicals inspection & testing institute Japan, 2-42.
Hüls AG (1985). Prüfung der akuten Augen- und|Schleimhautreizwirkung von Laurinlactam. Report No. 0354|(unpublished)
Method: other: OECD Guideline 405 "Acute Eye Irritation/Corrosion" (1981)
Huntingdon Research Centre Ltd. (1988) Assessment of ready|biodegradability of Dynasylan IBTEO Kondersat. Report DNN|28(a)/88668. Degussa-Huls AG-Nr.: 88-0329-DGO August 15,|1988
Atkinson,R., Carter,W.L., Chem. Rev.84, 437-470, 1984, No information
Phototransformation in air, IUC4#11/Ch.3.1.1
Hoechst AG (1978): Unpublished results (4/78)
BASF AG: Department of Toxicology, unpublished study, Report on industrial hygiene tests (Gewerbetoxikologische Vorprüfung), (XII/248), October 04, 1962
Aeschbacher, H.U. et al.: Mutat. Res. 174, 53-58 (1986)
Method: other: according to Allen, J.W. et al.: Somat. Cell. Genet. 4, 393-406
Genetic toxicity in vivo, IUC4#43/Ch.5.6
AOPWIN. Version 1.90. Atmospheric Oxidation. EPIWIN v.3.10|(Estimation Program Interface for Windows). US.|Environmental Protection Agency (2000)
Method: other (calculated): AOPWIN v1.90
Yoshimi N., Sugie S., Iwata H., Niwa K., Mori H., Hashida|C., Shimizu H (1988): The genotoxicity of a variety of|aniline derivaties in a DNA repair test with primary|cultures rat hepatocytes; Mut. Res. 206(2), 183-191
Genetic toxicity in vitro, IUC4#21/Ch.5.5
Wong, P.T.S., Y.K. Chau, O. Kramar, and G.A. Bengert. 1982. Structure-toxicity relationships of tin compounds on algae. Can. J. Fish. Aquat. Sci. 39:483-488.
Basic Acrylic Monomer Manufacturers. Study on the Soil Adsorption Ricerca, Inc. Department of Environmental Sciences. Project Identification No. 88-0215. Painesville, OH. 1991
Randall DJ and Bannister RM (1990) Acute toxicologic|evaluation of Santoflex' 13 antiozonant. Acute Toxicity Data|1: 67-68
Call DJ, Brooke LT, Ahmad N, Vaishnav DD (1981). Aquatic|Pollutant Hazard Assessments and Development of a Hazard|Prediction Technology by Quantitative Structure-Activity|Relationships. Center for Lake Superior Environmental|Studies, University of Wisconsin.
Short-term toxicity to fish, IUC4#9/Ch.4.1
Pitter, P., Determination of biological degradability of|organic substances, Water Res. 10, 231-235, 1976 (28).
RBM study report no. 950102 (1996).|Istituto di Recerche Biomediche, Via Ribes 1, 10010|Colleretto Giacosa, Italy||Sponsor (and substance provided by) Industrie Chimche|Caffaro.
Merck (1990) Institut f. Toxikologie, unveroeffentlichter|Bericht Nr. 40/133/90.
BASF AG (1972). Department of Toxicology, acute oral toxicity rabbit/dog, unpublished report, Study No. XXI/183, 19 October 1972.
Hoechst AG (1993): Sicherheitsdatenblatt|o-Nitrochlorbenzol TTR (26.03.1993); document not available
Dill, D.C., (1978). Evaluation of Dowanol PPH (propylene|glycol phenyl ether) in the aquatic environment. Dow Report|No. ES-259. November 7, 1978. Unpublished report.
Rost E, Franz F (1904) Vergleichende Untersuchung der|pharmakologischen Wirkungen der organisch gebundenen|schwefligen Säuren und des neutralen schwefligsauren|Natriums. Arb Kaiserl Gesundheitsamt 21: 312-371 (In German)
Liu J and Lang P (1995). Toxicities of nitroaromatic|compounds to Scenedesmus obliquus and toxic symptoms.|Huanjing Keyue 16 (2), 7-10.
Method: other: OECD-Guideline 201 (algae, Growth inhibition test, 1981)
Toxicity to aquatic algae and cyanobacteria, IUC4#80/Ch.4.3
Gizhlaryan, M. S. et al. (1986) Gig. Sanit. 7, 77-78.
Repeated dose toxicity: oral, IUC4#50/Ch.5.4
BASF AG, Toxicology Research Department, study report,|23.11.1979
Boublik et al. (1984) cited in EPIWIN 3.1
Duprat and al. (1974): Pouvoir irritant sur la peau et|l'oeil du lapin de l'eau de Javel.,I.N.R.S., Revue Med. vet.|125, 6, 879-895.
Biodynamic Inc., Project No. 89-3536, January 24 (1991)|(at the request of Synthetic Organic Chemical Manufacturers|Association Inc.).
Developmental toxicity / teratogenicity, IUC4#40/Ch.5.8.2
Guzzie, P.J. and E.R. Morabit. 1988. Organofunctional Silane|A-1120 Salmonella/Microsome (Ames) Bacterial Mutagenicity|Assay. Bushy Run Research Center Project Report 51-30, May|23, 1988.
Method: other: EPA Health Effects Test Guidelines, HG-Gene Muta-S. typhimurium, EPA Report 560/6-84-002, 1984
Repeated dose toxicity: oral, IUC4#104/Ch.5.4
Method: other: German Standard DIN 38412 part 15
Method: other (calculated): MPBPWIN, vers. 1.28
Nakai SA and Siebert KJ (2003). Validation of bacterial|growth inhibition models based on molecular properties of|organic acids. International Journal of Food Microbiology|86, 249-255.
Method: other: method of Hsiao & Siebert (1999)
Reported in HSDB-Data Bank from Lyman W.J. et al. (1982)|Handbook of chemical property estimation methods. NY:McGraw|-Hill Chapt. 4, 5 & 15 and from Taft R.W. et al. (1985).|Nature, 313:384-386.
Industrial Health Foundation Inc. (1977) Final Report on 90 day Inhalation-Thyroid Exposure to Resorcinol; Industrial Health Foundation Inc. Feb 1977 American Industrial Hygiene Assoc. 37, Oct. 1976 (conducted for Koppers Company).
Method: other: not conducted to any guidelines
Repeated dose toxicity: inhalation, IUC4#12/Ch.5.4
Daubert, T.E., and R.P. Danner (1989) (Data from MPBPWIN|v1.40 database in EPIWIN Suite.)
Schering AG, Experimentelle Toxikologie. 1998. Acute immobilization test of di-n-butyltin bis(2-ethylhexylthioglycolate) (ZK 26386) with Daphnia magna. Research Report No. IC15. Berlin, Germany.
Method: other: comparable to OECD Guideline 202 and EC Guideline 92/69/EEC
Schering. 1989. ZK 24.942. Evaluation in the Ames Salmonella/microsome mutagenicity test with preincubation. Bericht Nr. IC 09/89. 02.03.1989.
Method: other: Ames et al. (1975); Maron and Ames (1983)
Flaningam, O. (1995) Trimethoxysilane. Dow Corning|Corporation. Midland, Michigan. Private Communication.|July 31, 1995.
Galloway, S.M. et al.: Environ. Mutagen. 7, 1-51 (1986), No information
Genetic toxicity in vitro, IUC4#346/Ch.5.5
Goldsworthy TL and Popp JA (1986). The hepatocarcinogenicity|of dinitrotoluenes. CIIT Activities 6, 1-5.
Method: other: initiation-promotion liver foci assay
Korth W., Ellis J. and Bowmer K., 1992, The stability of|geosmin and MIB and their deuterated analogues in surface|waters and organic solvents, Water Sci. Technol. 25, 115-122
Method: other: biodegradation test using spiked river water
Exxon Biomedical Sciences (1991). Project No. 236535, 26 Nov 1991 (sponsored by GAF Corp., Wayne, USA)
Method: other: comparable to OECD Guide-line 416 and EPA OTS 798.4700
Smyth H.F., Carpenter, C.P., Weil, C.S. and Pozzani, U.C.|(1953), "Range-finding Tests on Epsilon-caprolactone",|University of Pittsburgh, Report No. 16-59
Wells Laboratories, Inc. 1973. Report on Inhalation LC50 Testing Using Monomethyltin Trichloride. 12.7.1973.
Method: other: USDA Regulation 362.8, Title 7, Chapter III, Part 362.
Ministry of International Trade and Industry (MITI). 1992. Biodegradation and bioaccumulation data of existing chemicals based on the Chemical Substances Control Law|(CSCL), Japan. Chemical Industry Ecology - Toxicology and Information Center 1-27, 2-73
Diploid human embryonic lung cells (WI-38) in tissue culture
Salmonella typhimurium TA98 TA100 TA1535 TA1537
Weast, R.C. (ed.) Handbook of Chemistry and Physics. 64th|ed. Boca Raton, Florida: CRC Press Inc., 1983-1984., p. B-79
Eckert JW (1962) Fungistatic and Phytotoxic Properties of|Some Derivaties of Nitrobenzene. Phytopathology 52: 642 -|649
Hüls AG (1989). Prüfung auf hautsensibilisierende Wirkung am|Meerschweinchen von Laurinlactam. Report No. 1473|(unpublished)
Method: other: OECD Guideline 406 "Skin Sensitization" (1981)
Bucher JR, Huff J and Kluwe WM (1986). Toxicology and|carcinogenesis studies of isophorone in F344 rats and B6C3F1|mice. Toxicology 39, 207-219.
Method: other: Repeated Dose Toxicity, U.S. NTP
Jaekel K (1992) FAT 65'023/N: Partition Coefficient.|Ciba-Geigy Ltd., CH-4002 Basel (Switzerland)
Bringmann G and Kühn R (1959). Vergleichende|wasser-toxikologische Untersuchungen an Bakterien, Algen und|Kleinkrebsen. Gesundheits-Ingenieur 80(4), 115-120.
Daubert TE, Danner RP (1989). Physical and thermodynamic|properties of pure chemicals. Data Compilation,|Dicyclohexylamine. Taylor and Francis, Washington, DC.
BASF AG (2005). Department of Product Safety. Unpublished calculations. Epiwin. 05 September 2005.
Method: other: calculated with MPBPWIN v1.41
Monsanto Material Safety Data Sheet, Santoflex 13,|Antiozonant, 4/86
BIBRA International (1993) Toxicology profile: Acetic acid|and its common salts. BIBRA International
Sunwin Chemicals Co., Ltd. (2006). Product data sheet, 23|Oct 2006.
Bermudez, E. et al.: Environ. Mol. Mutagen. 11, 13 (1988),|abstract no. 28, No information
Genetic toxicity in vitro, IUC4#90/Ch.5.5
Method: other: revised FHSA procedure proposed by FDA (US)
Infracor Degussa Group (1993) Final Report AW 321: DYNASYLAN|GLYMO Determination of the growth of the green algae|Scenedesmus subspicatus (Algal growth inhibition test)|(English translation of the German Final Report dated|26.07.1993). Degussa AG-Nr.: 93-0201-DGO.
FMC Corporation, Material Safety Data Sheet: Potassium|persulfate (02-05-01: date approved), 2001.
Poon R, Lecavalier P, Chu I, Yagminas A, Nadeau B, Bergman A, Larsson C. (1999). Effects of bis(4-chlorophenyl) sulfone on rats following 28-day dietary exposure. J Toxicol Environ Health A. 1999 Jun 11;57(3):185-98.
Crosby, R.M. et al.: Environ. Mol. Mutagen. 12, 155-166|(1988), No information
Jain PC and Agrawal SC (1978). Growth responses of some|keratinophilic fungi by volatile substances. Trans. mycol.|Soc. Japan 19, 293-297.
Toxicity to microorganisms, IUC4#22/Ch.4.4
Genetic toxicity in vitro, IUC4#78/Ch.5.5
Union Carbide Corp. (1987). Isophorone diisocyanate - 1-Isocyanato-3-isocyanatomethyl-3,5,5-trimethylcyclohexane - range finding toxicity studies. NTIS/OTS Microfiche 0515604, Doc 86-870001442.
Budavari S., O'Neil M., Smith A., Heckelman P. and Kinneary J. (1996). The Merck Index. An Encyclopedia of Chemicals, Drugs and Biologicals. 12th Edition. Merck & Co., Inc. Whitehouse Station, NJ.
Obe G, Hille RJ, Schmidt S, Thenhaus U (1985) Tests for the|induction of sister-chromatid exchange in human peripheral|lymphocytes in culture. Prog Mut Res 5: 439-442
Genetic toxicity in vitro, IUC4#126/Ch.5.5
Rakhmanin (1965): Gig. Sanit. 30(9), 22-28. As cited in: The|Registry of Toxic Effects of Chemical Substances (RTECS).|2-Naphthol. RTECS# QL2975000. Update July 2000.
Mikami, N. et al., Chemosphere 5, 311-315 (1979)
Janssen P., de Rooy C., Evaluation of the toxicity and|metabolism of glycerine, polyglycerines and polyglycerine|esters, Solvay-Duphar (Weesp) (5)
Wiles A.J. and J.K. Narcisse (1971). Am. Ind. Hyg. Assoc. |J. 32:539-545.
BASF AG (1977). Department of Ecology. 5th VCI ringtest 1977|(unpublished).
Method: other: according to Zahn-Wellens (later OECD Guide-line 302 B)
Biodegradation in water: screening tests, IUC4#31/Ch.3.5
Carpenter CP & Smith HF (1946) Chemical burns of the rabbit|cornea. Am J Ophthal 29: 1363-1372
Koopman, T.S.M. and Pot, T.E. (1986) Acute oral toxicity|study with calcium chloride dihydrate in male rabbits.|Duphar Report No. 56645/51/86.
Gamer, A.O., Kirsch, P., Freisberg, K.O., (1991). Study on|the Acute Inhalation Toxicity LC50 of Protectol PP as a|Liquid Aerosol in rats, 4-hour exposure. BASF|Akteingesellschaft. Study No. I3I0634/907055, August 30,|1991. Unpublished.
Akatsuka, K., Hashimoto, T. and Takeuchi, K. (1977)|Pharmacological studies on Ca meso-tartrate I. Acute and|subacute toxicity tests. Ouyou-Yakuri, 14, 963-975. (in|Japanese)
Adema DMM, de Zwart D (1984). Onderzoek naar een geschikte|combinatie toetsmethoden ter bepaling van de aquatische|toxiciteit van milieu-gevaarlijke stoffen, Bijlage 2:|Onderzoek naar de bruikbaarheid van Lemna minor (eendekroos)|voor routine toxiciteitsonderzoek en vergelijking van deze|waterplant met eencellige groenalgen (Rapport nr.: CL|81/100b, RIVM 668114 003)
Toxicity to aquatic algae and cyanobacteria, IUC4#23/Ch.4.3
Cambridge Soft Corporation. (2004). Chemfinder on-line.|http://chemfinder.cambridgesoft.com/
Oldersma, H., A.O. Hanstveit, and H.P.M. de Haan. 2004. Dibutyltin bis (2-ethylhexylmecaptoacetate) (CAS# 10584-98-2) (DBT(EHMA)): Determination of the effect on the growth of the fresh water green alga Scenedesmus subspicatus. TNO Chemistry. Report V5310/02. May 18, 2004 (revised final June 2, 2004).
Izmerov, N.F., et al. (1982) Toxicometric Parameters of|Industrial Toxic Chemicals under single Exposure. United|Nations Environment Programme (UNEP), International Register|of Potentially Toxic Chemicals (IRPTC). Moscow, Centre of|International Projects, GKNT, 64
Ema, M., R. Kurosaka, H, Amano, and Y. Ogawa. 1995. Comparative developmental toxicity of butyltin trichloride, dibutyltin dichloride, and tributyltin chloride in rats. J. Applied Toxicol. 15(4):297-302.
BASF AG, Laboratory of Ecology, unpublished data, (1200/87)
Method: other: "Algentest in Anlehnung UBA"
M&T Chemicals Inc., TSCAT, OTS0200247, Doc I.D. 88-8400561,|Bio/dynamics Inc.: Project No. 81-7534 A, 01 Dec. 1982, 11 Oct. 1983
Tuazon E.C., Atkinson, R. and Corchnoy, S.B. Rate constants|for the gas-phase reactions of Cl atom with a series of|hydrofluorocarbons and hydrochlorofluorocarbons at 298 +/-|2K Int J Chem Kinet, Vol 24, 639-648, 1992
MITI, Japan (Ministry of International Trade and Industry of|Japan) (1992). published data, Screening biodegradability|test
Hazleton U.K. (1989): Acute inhalation toxicity study - LC50 rats, Report No. 5907-556/4, April 1989
Repeated dose toxicity: oral, IUC4#13/Ch.5.4
OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
BASF AG, department of ecology, unpublished data (1282/88),|16.12.1988
Method: other: according to DIN 38412, part 9
Ward, T.J., P.L. Kowalski, and R.L. Boeri. 1995. Acute toxicity of the water accommodated fraction (WAF) of alkyltin MA to the freshwater alga, Selenastrum capricornutum. T.R. Wilbury Laboratories, Inc. T.R. Wilbury Study Number 865-MO.
Dambleff J (1908). Beiträge zur Kenntnis der gifitigen|Wirkung nitrierter Benzole und Toluole insbesondere von der|Haut aus. Inaugural-Dissertation. Würzburg.
Weiner M.L., Salminen W.F., Larson P.R., Barter R.A., Kranetz J.L., Simon G.S.
Kashima, R. et al.: Contact Dermatitis 28, 235-242 (1993), No information
Bornmann G., Grundwirkungen der Glykole und ihre Bedeutung|fuer die Toxizitaet, Arzneim Forsch 4: 643-646, 1955 (20)
Xie D.Y. et al., Biomed.Environ.Sci., 3(3), 281-289 (1990b)
Bringmann G, Kühn R (1977) Grenzwerte der Schadwirkung|wassergefährdender Stoffe gegen Bakterien (Pseudomonas|putida) und Grünalgen (Scenedesmus quadricauda) im|Zellvermehrungshemmtest. Z Wasser Abwasser Forsch 10: 87 -|98
Toxicity to aquatic algae and cyanobacteria, IUC4#95/Ch.4.3
Sasaki, Y. and Endo, R.: Mutat. Res. 54, 251-252 (1978);|abstract no. 27, No information
Genetic toxicity in vitro, IUC4#46/Ch.5.5
Deneer, J.W. et al.: Aquatic Toxicol. 12, 185-192 (1988)
Method: other: according to Alabaster, J.S. and Abrams, F.S.H.: Adv. Water Poll. Res., Proc. 2nd Int. Conf. Tokyo, Vol 1, Pergamon Press, Oxford (1964)
CIIT (1983) Chronic Dietary Administration Of Terephthalic|Acid. CIIT Docket 20124
Method: other: germination and growth of seedlings in sand
BASF AG (1979). Stoffdatenservice GCT/D - L443, 20 Feb 1979.
Exxon Biomedical Sciences (1992). Project No. 136534, 05 Jun 1992 (sponsored by GAF Corp., Wayne, USA)
Method: other: comparable to OECD Guide-line 414, EPA OTS 798.4900
Developmental toxicity / teratogenicity, IUC4#24/Ch.5.8.2
BASF AG, Department of Toxicology, Ergebnis der|Gewerbetoxikologischen Vorprüfung, unpublished report|(XX/24), 20 July 1970
Salmonella typhimurium TA1535, TA1537, TA 1538
Woutersen, R.A. et al.: J. Appl. Toxicol. 7 (1), 43-49|(1989), No information
Repeated dose toxicity: inhalation, IUC4#81/Ch.5.4
Ministry of Environment, Japan (1999c): unpublished report on toxicity to algae
Abdernalden`s Handbuch der Biologischen Arbeitsmethoden 4,|p. 1289. Leipzig (1935). As cited in: The Registry of Toxic|Effects of Chemical Substances (RTECS). 2-Naphthol. RTECS#|QL2975000. Update July 2000.
CH1-L (fibroblasts from the liver of Chinese hamster)
Blakey DH., Maus KL., Bell R., Bayley J., Douglas GR.,|Nestmann ER. (1994). Mutagenic activity of industrial|chemicals in a battery of in vitro and in vivo tests. Mutat.|Res. 320(4), 273-283
Bayer AG (1989) Grunddatensatz für Altstoffe über 1000 JATO|vom 30.08.1989, 1 - 6
Cannon Laboratories, Inc. (1974) The acute dermal LD50 of Vicinal Isomer mix in New Zealand Albino Rabbits. Reading PA. Report No. 4E-4018. Air Products and Chemicals Inc.
Ullmann L. Contact hypersensitivity to FAT 65'023/L in|albino Guinea pigs (Maximization test). Report RCC project|No. 288494, April 2, 1991; RCC, Itingen Switzerland.
Olson, K., Unpublished report of The Dow Chemical Company|(1960)
National Institute of Environmental Research (NIER), Korea.
Test on stability of DKP in algae OECD medium. This study was not conducted according to the OECD TG 111.
Short-term toxicity to fish, IUC4#46/Ch.4.1
National Toxicology Program: Annual Plan for Fiscal|Year 1984. NTP-84-023 (1984)
Rogan, E. G. et al.: Chem.-Biol. Interactions 58, 253-275|(1986)
Thompson ED, Coppinger WJ, Valencia R and Iavicoli J. 1984. Mutagenicity testing of diethylene glycol monobutyl ether. Environ Health Perspect 57:105-112
Springer W, Rast HG (1988) Biologischer Abbau mehrfach|halogenierter mono-und polyzyklischer Aromaten. GWF Wasser|Abwasser 129: 70 - 75
Cairns J.Jr. et al. (1990): Evaluation of joint toxicity of|chlorine and ammonia to aquatic communities. Aquatic|Toxicology, 16(2), 87-100
Lewis RJ (2000) Sax's Dangerous Properties of Industrial Materials. Wiley Interscience Publication, New York, 10th ed., 2145-2146.
Kramer VC (1983). Relative toxicity of organic solvents to|Aedes aegypti Larvae. Journal of Invertebrate Pathology 42,|285-287.
Short-term toxicity to aquatic invertebrates, IUC4#19/Ch.4.2
Rowe EH and Tullos Jr. LF (1980). Lube solvents no threat|to waste management. Hydrocarb. Proc. October 1980, 63-65.
Method: other: WWTP simulation unit, continuous-flow, retention time 18 h
Younger Labs, Toxicological investigation of|o-nitrochlorobenzene, at the request of Monsanto Co.,|EPA-OTS0534828, 1991
Method: other: 0.5 ml/rabbit, warmed, observation time: 168 hours (no further information)
US EPA, Chemical hazard information profile BHT, draft|report (1984)
BASF AG, Department of Ecology, unpublished study,|2/0012/88, 15.07.1988
Method: other: German National Standard: DIN 38412, Part 9, Determination of inhibitory effect on the cell multiplication
INRS (Institut national de recherche et de sécurité), Paris (1988). Diisocyanate d'isophorone. Fiche Toxicologique 166, 1-4.
Anon (1988) Dangerous Properties of Industrial Materials|Report 8, 68-71
Union Carbide Data Sheet (12/29/71); zitiert in cited in: RTECS (1991)
Abu-Hijleh, G. et al.: FASEB J. 12 (4 Pt 1), A318 (1998);|abstract no. 1852
Developmental toxicity / teratogenicity, IUC4#13/Ch.5.8.2
Rosenberg M.R. et al. (1985). Cancer Res. 45, 809.
Klecak, G. et al.: J. Soc. Cosmet. Chem. 28, 53-64 (1977)
Dabrock B., Bahl H. & Gottschalk G., Parameters affecting|solvent production by Clostridium pasteurianum, Appl.|Environ. Microbiol. 58 (4): 1233-1239, 1992 (88).
Purchase I et al. (1978): An Evaluation of 6 short-term|tests for detecting organic chemical carcinogens. Br. J.|Cancer 37, 873-903
Method: other: according to the method described by Ames (1975)
Method: other: see freetext; comparable to OECD Guide-line 473
Barrow CS and Steinhagen WH (1982) Toxicol Appl Pharmacol,|65, 383-389
Acute toxicity: inhalation, IUC4#16/Ch.5.1.2
Wells Laboratories, Inc. 1976. Report on inhalation LC50 in rats using dioctyltin dichloride. Laboratory No. G-1406. 28.01.1976.
Henderson D.S. and T.A. Griglatti: Mutagenesis 7, 399-405,|(1992)
Ananie, D. and Y. Huang. 2001. Effects of exposure to dibutyltin dichloride on sperm density, viability and morphology in male mice. Applied Organometallic Chemistry. 15:727-732.
BASF AG Unpublished report ZST_ Nr XXIII/236-2. 24|.11.1977
Nelson, B.K., Brightwell, W.S., Robertson, S.K., Kahn, A.,|Krieg, E.F., Jr. and Massari, V.J. Behavioral Teratology|investigation of 1-Butanol in Rats. Neurotoxicology and|Teratology. 11(3): 313-315, 1989a.
BASF AG, (1978c) Cytogenetic investigation in the bone marrow of rats after 4-day inhalation, Dept. of Toxicology, unpublished study, (XXVI/352), May.12, 1978
Method: other: OECD 475; and the method of Schmid and Staiger (1969).
LPT, Hamburg (1999). Acute eye irritation study of|calciumformiat technisch by instillation into the|conjunctival sac of rabbits. Unpublished study report No. R|7507, dated September 22, 1999. Sponsored by Bayer AG,|Wuppertal. Bayer study No. T5067228.
McCann, J. et al.: Proc. Natl. Acad. Sci. USA 72, 5135-5139|(1975);|cited in: RIFM database, location no. 4023
McKinney, R.E., Jeris, J.S. (1955) Metabolism of low|molecular weight alcohols by activated sludge. Sewage Ind.|Wastes, 27(6):728-735.
Riddick, Bunger, and Sakano (1986). Organic Solvents|Physical Properties and Methods of Purification, 4th|Edition, Volume II. P. 201.
Janssen, P.J.M. (1991), "Primary irritation study of|epsilon-caprolactone to the eye of male rabbits", Solvay|Duphar Int. Doc. No. 56645/106/91
HSE (Health & Safety Executive): N-Methyl-2-pyrrolidone -|Risk assessment document. UK, 1997
Developmental toxicity / teratogenicity, IUC4#11/Ch.5.8.2
RBM study report no. 950101 (1996).|Istituto di Recerche Biomediche, Via Ribes 1, 10010|Colleretto Giacosa, Italy||Sponsor (and substance provided by) Industrie Chimche|Caffaro.
Dow Corning Corporation (1980) Acute static toxicity of Dow|Corning Z-6075 Silane to Daphnia, bluegill, rainbow trout|and two species of algae. Dow Corning Corporation, Report|No. 1980 I0005 0743, 14 May 1980.
Method: other: Biological field and laboratory methods. The algal assay procedure: bottle test. United States Environmental Protection Agency, EPA 670/4 73 00, 1973
Rinehart, WE, Acute Dermal Toxicity Study in Rabbits, |Toxicological Resources Unit, Bio/dynamics Inc., 1978.
IARC Monographs on the Evaluation of the Carcinogenic Risk|of Chemicals to Humans. Some Halogenated Hydrocarbons and|Pesticide Exposures. International Agency for Research on|Cancer, World Health Organization, ISBN 92 832 1241X, ISSN|0250-69555 (1986).
Hooftman, R.N. and J.M. de Wolf. 2003. Dichlorodioctylstannane (CAS # 3542-36-7): Semi-static acute toxicity test with the zebra fish Brachydanio rerio. TNO Report No. V2497/03. September 2003.
Auergesellschaft: AUER Technikum, Ausgabe 12 (1988), p. 195
Brauwers, C. (1982): Effects of brief exposure to H2SO3 on|growth of Chlorella pyrenoidosa. Bull. Soc. R. Bot. Belg.|115(1), 69-77
Toxicity to aquatic algae and cyanobacteria, IUC4#110/Ch.4.3
Emmett E. A. et al, Allergic Contact Sensitization to The Toluic Acids, The Journal of Investigate Dermatology, 61|(5), 282-285, 1973
Matlou, S.M., Isles, C.G., Higg, A., Milne, F.J., Murray, G.D., Schultz, E., Starke, I.F. (1996). Potassium supplementation in blacks with mild to moderate essential hypertension. J. of Hypertension 4:61-64.
Method: other: Shake-flask method comparable to Gledhill method listed in U.S.E.P.A. 40 CFR Ch 1 subpart D paragraph 796.3100.
Liu DHW, Bailey HC, Pearson JG (1983). Toxicity of a complex|munitions wastewater to aquatic organisms. Aquatic|Toxicology Hazard Assessment, 6th symposium, 135-150.
Gladenko I.N., Zajceva L.D. and Sevcova G.N.: Toxicity of|Isobutylidene diurea. Veterinariya (Moscow) (57)10, 60-61|(1980) (in Russian)
Method: other: no data or see Test Conditions
Druckrey, H. (1968): Chlorinated drinking water, toxicity|studies on seven generations of rats. Food Cosmet Toxicol,|6, 147-154.
Ingle AO, Purohit HJ, Daginawala HF (1983) Studies on the Biodegradation of Resorcinol by Indigenously Isolated Bacteria, Mold and Yeast, Department Department of Biochemistry and Microbiology, Nagpur University, Nagpur-440 010, India.
Biodegradation in water: screening tests, IUC4#13/Ch.3.5
Jaworska JS, Hunter RS, Gobble JR, Schultz TW (1997)|Structure-activity relationships for diesters: aquatic|toxicity to Tetrahymena. pp. 277-283.
Eastman Kodak Company (2008) Response to|3-Mercaptoproprionic Acid Data Request October 27, 2008.|Letter from Deborah Rice Gordon, M.S., DABT Eastman Kodak|Company Worldwide Toxicology, 1999 Lake Avenue, Rochester,|NY 14650-2206 to Darrell Bradfield, Kodak Service and|Support, 4020 Stirrup Creek Drive, Suite 100, Durham, NC|27703.
DuPont (1983). Haskell Laboratory. Literature review of 1,4-dichloro-2-butene. Unpublished Data.
Chemicals Evaluation and Research Institute (CERI), Japan|(2000), Report number 80015BK, Unpublished data.
Mesch, K.A. and T.G. Kugele. 1992. Use of Organotin Stabilizers - Risk Assessment Analysis. J. Vinyl Tech. 14:131-134.
Ministry of Health, Labour and Welfare (MHLW), Japan (2001) Toxicity Testing Reports of Environmental Chemicals, 8, 837-865.
Genetic toxicity in vitro, IUC4#40/Ch.5.5
Huls (1993) Final Report SK-93/22 Determination of bacterium|toxicity of DYNASYLAN GLYMO in the Oxygen Consumption Test|(Huls method). Degussa AG-US-IT-NR. 93 0205 DGO.
Ishidate Jr., M.: Test Courts Cancerog. Quo Vadis (Symp.|1981), 57-79 (1983), No information
Genetic toxicity in vitro, IUC4#135/Ch.5.5
Dow Corning Corporation Internal Report Number|1982-I0005-4122-09
American Cyanamid|unpublished data|cited in Burg et al. 1977
Foureman P. et al., Environm. Molec. Mutagen. 23, 208-227|(1994)
BASF AG (2005). Department of Product Safety, data|assessment, EPIWIN (v3.12), 16 Mar 2005 (unpublished).
Method: other: calculated with WATERNT Program (v1.01)
Arnold, L.L. et al, Fundamental and Applied Toxicology,|40,247-255 (1997)
Voelskow, H., Bakterienkulturen zum Abbau substituierter|Aromaten, Vom Wasser 63, 87 - 92 (1984)
Method: other: various adaptation technologies (see test condition)
Biodegradation in water: screening tests, IUC4#5/Ch.3.5
Briggs, G.G. Theoretical and Experimental relationships between soil adsorption, octanol-water partition coefficients water solubilities, bioconcentration factors and the parachor. J. Agric. Food Chem. 29, 1050-9, 1981
Biodegradation and Bioaccumulation Data of Existing|Chemicals Based on the CSCL Japan, Compiled under the|Supervision of Chemical Products Safety Division, Basic|Industries Bureau MITI, Ed. by CITI, October 1992. Published|by Japan Chemical Industry Ecology-Toxicology & Information|Center (1992)
Method: other: Japanese Guideline by MITI of 1974; corresponds to OECD 302C Modified MITI Test II
Maas-Diepeveen JL and van Leeuwen CJ (1986). Aquatic|toxicity of aromatic nitro compounds and anilines to several|freshwater species. Laboratory for Ecotoxicology, Institute|for Inland Water Management and Waste Water Treatment,|Ministry of Transport and Public Works (DBW/RIZA Report|86-42, tvl1296/84).
BASF AG, Department of Toxicology, Ames-Test (Standard Plate|Test and Preincubation Test with Salmonella typhimurium),|unpublished study, Project-No. 40M0445/884130, 12 Oct. 1988
Method: other: OECD guideline 471 (1983)
Bills, D. et al.: "Investigation in fish control. 73.|Formalin, its toxicity to nontarget aquatic organisms,|persistence and counteraction"; Washington DC, U.S.|Department of the Interior, Fish and Wildlife Service, 1-7,|(1977);|cited in: IPCS Environ. Health Crit. 89, (1989), No information
Short-term toxicity to fish, IUC4#73/Ch.4.1
Kondo M et. Al., (1988) Biodegradation Test of Chemicals by|Cultivation Method, EISEI KAGAKU 34, 188 - 195
Ciba (1987). Internal report. Additives Division. July 3,|1987.
Ciba-Geigy Ltd., Final report TK10044, Lifetime|carcinogenicity study in mice, Project No 784333, 11.1.1982.
Toxicity to soil macroorganisms except arthropods, IUC4#10/Ch.4.6.3
United States Environmental Protection Agency (2000) Office of Pollution Prevention and Toxics and Syracuse Research Corporation, 2000. EPISuite v 3.12 (October 2006).
Handbook of Environmental Data on Organic Chemicals (2001)|4th Edition; John Wiley and Sons.
BASF (1983). Loesungsmittel PM: Ames test, with cover sheet dated 061289, BASF Corp. EPA/OTS; DOC#86-8900007694, OTS 0521200.
CRC Handbook of Chemistry and Physics. 1979. R.C. Weast (ed.). 60th ed. CRC Press, Inc. Boca Raton, FL. p. C-716.
Hawley's Condensed Chemicals Dictionary, 15th edtion, John Wiley & Sons, Inc., 2007.
Yoshimura, Machida, Masuda (1980): JAOCS 7, 238-241
Stasenkow, K.P. and Kotschekov, T.A., Toksikol. Nerykh Prom.|Khim. Veshchestr., 7, 27-38, 1965
Dow Corning Corporation (1987) Dow Corning Internal report|No. 1987-I0005-1606
Tanii H and Hashimoto K: Structure-Toxicity Relationship of|Acrylates and Methacrylates. Toxicology Letters 11, 125-129|(1982)
Mutagenicity Evaluation of FDA 75-86 Niacinamide, Litton Bionetics, 09/77, Brusick D. J., for FDA
Biosphere Research Center Inc. (1981). Dermal sensitization study of compound number 11583B15 and isophorone diisocyanate. Report No. 81-149. American Cyanamid Company Wayne (NJ, USA).
Method: other: Standard Operating Procedures of Biosphere Research Center, Inc., 216 Congers Road, New City, New York 10956
BASF AG: Department of Toxicology, unpublished data, Report on the study of the acute oral toxicity of Isobutylacrylat in the rat, (XII/248), October 04, 1962
BG Chemie. Micronucleus Assay in Bone Marrow Cells of the|Mouse with Isobutylidenediurea. RCC-CCR Project 597 300. Nov|05, 1999
Takahashi A and Ono H (1993). Mutagenicity assessment in 44|epoxy resin hardeners in Salmonella typhimurium. Chem.|Express, 8, 785-788.
Method: other: Ames, B.N., McCann, J. and Yamasaki, E. (1975) Mutation Res., 31, 347-364.
Spain JC, Nishino SF, Greene MR, Forbort JE, Nogalski NA,|Unterman R, Riznychok WM, Thompson SE, Sleeper PM, Boxwell|MA (1999) Field demonstration of FBR for treatment of|nitrotoluenes in groundwater. In: Proceedings of the 5th|International in Situ and on-Site Bioremediation Symposium,|Bioremediation of nitroaromatic and haloaromatic compounds,|Battelle Press, Columbus, OH, pp 7 - 14
Koltoff I. and Miller I K (1951). The chemistry of|persulfate. I. The kinetics and mechanism of the|decomposition of the persulfate ion in aqueous medium. J.|Am. Chem. Soc., 73, 3055-3059.
FMC Corp. data prepared for the US EPA (1985) cited in|Environmental Health Criteria 112, World Health|Organization (1991)
CERI (2004) Database of Biodegradation and|Bio-Accumulation Data of Existing Chemicals. Chemicals|Evaluation and Research Institute, Japan. Available at|http://qsar.cerij.or.jp/cgi-bin/DEGACC/index.cgi?E
Ema, M. and A. Harazono. 2000. Adverse effects of dibutyltin dichloride on initiation and maintenance of rat pregnancy. Reproductive Toxicology. 14:451-456.
National Toxicology Program (1999). Toxicology and|Carcinogenesis Studies of Isoprene (CAS No. 78-79-5) in|F344/N Rats (Inhalation Studies). NTP TR-486. NIH|Publication No. 99-3976.
Repeated dose toxicity: inhalation, IUC4#7/Ch.5.4
BASF AG (2005). Department of Product Safety, data|assessment, EPIWIN (v3.12), 12 Jan 2005, unpublished.
Method: other: calculated with BCFWIN (v2.15)
Raake, W. and A. Schmid (1973) Toxicological Testing of|Trimethoxysilane [Letter Report from the University of|Munich to Dr Riedle, Walker Chemical Company., Munch,|Germany] July 1973. Cited in AIHA (1997) Workplace|Environmental Exposure Level Guides: Trimethoxysilane|(1997).
BASF AG, Labor Oekologie; unveroeffentlichte Unter-|suchung, (0903/88)
Wehner, E. and Brendel, M.: Mutat. Res. 289, 91-96 (1993), No information
Method: other: Yeast gene mutation assay
Genetic toxicity in vitro, IUC4#57/Ch.5.5
BASF AG, Department of Toxicology, unpublished studies|(78/623), 14 Feb. 1979
Acute toxicity: inhalation, IUC4#41/Ch.5.1.2
Sax NI (1979). Dangerous Properties of Industrial Materials|(5th ed.). New York, Van Norstrand Reinhold Company, 913.
Bringmann G. et al (1980), Z. vom Wasser, 50, 45-60.
JAPAN: Guidelines for Screening Mutagenicity Testing Of Chemicals
BASF AG, unpublished calculations, Mackay Level I, V 2.11 Model, EPIWIN V 3.10, ECOSAR V 0.99, AOP V 1.87, Hydrowin V 1.67, KOWWIN V 1.60, Henrywin V 3.10, BCFWIN V 2.14, 2002
Method: other (calculated): Hydrowin v1.67
B. subtilis strains M45 (rec-) and H17 (rec+)
Pennington DW (2001). Relationship of approaches and a|tiered methodology for screening chemicals in the context of|long-range transport. Chemosphere 44, 1617-1631.
Reported in AIDA (13/11/92)-ALSTOFF INFORMATION Date Bank |from Applegate V.C. et al. (1957). Special Sci. Report|Fishes, No. 207.
Anon., Farmatsevtichnii Zhurnal (Kiev) (V/O Mezhdunarodnaya Kniga. 113095 Moscow, Russia) Vol (6) page 56 1977.
Dutch Ass. of Safety Experts, Dutch Chemical Industry Ass.|and Dutch Safety Institue.,(1998). Handling Chemical, 13th|ed.
Salmonella typhimurium TA98, 100, 1535, 1537, 1538
Herbes SE, Beauchamp JJ (1977) Toxic interaction of mixtures of two coal conversion effluent components (resorcinol and 6-methylauinoline) to Daphnia magna. Bulletin of Environmental Contamination and Toxicology 17(1):25-32.
Becci PJ, Gephart LA, Koschier FJ, Johnson WD (1983)|Subchronic feeding study in Beagle dogs of|N-Methylpyrrolidone, J. Appl. Toxicol., 3, 83-86
Method: other: comparable to OECD Guide-line 409
Repeated dose toxicity: oral, IUC4#8/Ch.5.4
Okada T et al. (1985): Sensitization test of Naphthol AS on|guinea pigs. Nippon Hifuka Gakkai Zasshi 95, 1487-1489 (in|Japanese)
Smith, D.F. et al.: Cancer Res. 50, 5049-5054 (1990);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Genetic toxicity in vivo, IUC4#28/Ch.5.6
S. typhimurium TA102 and TA2638; E. coli WP2/pKM101 and WP2 uvrA/pKM101
Engelbrecht RS and McKinney RE (1957). Activated sludge|cultures developed on pure organic compounds. Sewage and|Industrial Wastes 24, 1350-1362.
Biodegradation in water: screening tests, IUC4#26/Ch.3.5
Huels AG (1995). unpublished report PF-043. Bestimmung der|Auswirkungen von Malonsäurediethylester auf das Wachstum|terrestrischer Pflanzen (Pflanzenwachstumshemmtest nach|OECD-Testguideline 208). Degussa AG-Reg-Nr.: 95-0322-DGO
Toxicity to terrestrial plants, IUC4#5/Ch.4.6.2
Principe P, Dogliotti E, Bignami M, Crebelli R, Falcone E,|Fabrizi M, Conti G, Comba P (1981) Mutagenicity of Chemicals|of Industrial and Agricultural Relevance in Salmonella,|Streptomyces and Aspergillus, Journal of the Science of Food|and Agriculture 32, 826-832
Dunster JS (2008). 4,4-Dichlorodiphenyl sulfone: Oral (gavage) Reproduction/Development Toxicity Screening Test in the Rat. Safepharm Laboratories Limited, Shardlow, United Kingdom. Sponsored by Solvay Advanced Polymers L.L.C.
Huels AG (1996e). Bestimmung der Bakterientoxizitaet von|Isophoron nach Bringmann und Kuehn, Report No.|ABBK-Isophoron (unpublished).
Method: other: Bringmann and Kuehn, Z. Wasser Abwasser Forsch. 10, 87-98 (1977)
Zsolnai T (1961) Versuche zur Entdeckung neuer|Fungistatika-II Nitro-Verbindungen. Biochem Pharmacol 5: 287|- 304
Toxicity to microorganisms, IUC4#58/Ch.4.4
Wilmer, J.W.G.M. et al.: Toxicol. Lett. 47, 287-293 (1989), No information
Repeated dose toxicity: inhalation, IUC4#75/Ch.5.4
Slesinski, R.S., Gaunt, M.W., Guzzie, P.J. and Hengler, W.C.|(1981), "In Vitro Mutagenesis Studies: 3-Test Battery",|Bushy Run Research Center, Project Report 43-125
Carere A, Bellincampi D, Conti G, Conti L, Crebelli R,|Gualandi G, Morpurgo G (1985) Genotoxic activity of selected|carcinogens in Aspergillus nidulans. Mut Res 147:|287-288
Method: other: growth-mediated technique
Genetic toxicity in vitro, IUC4#76/Ch.5.5
Devillers et al. (1987) Chemosphere 16:1149-1163.
Kott Y. and EDLIS J., 1969 . Effects of halogens on algae|Water Res. , 3(4), 251-256
Bermudez, E. and Delehanty, L.L.: Environ. Mutagen. 8, 11|(1986); abstract no. 26, No information
Genetic toxicity in vitro, IUC4#217/Ch.5.5
N.T.I.S. US Department of Commerce. Teratological evaluation|of glycerin in mice, rats and rabbits. Report No. PB-234876,|1974 (82)
Patty FA (1963). Industrial Hygiene and Toxicology, 2nd|revised ed..Vol.2, Interscience Publishers 1491-1492.
International Chemical Safety Card (ICSC 0853),|http://www.cdc.gov/niosh/ipcsngrm/ngrm0853.html, 2004
Method: other (calculated): EPIWIN Suite, 1997
BASF AG, Report on the study of the subacute toxicity of n-butyl acrylate in the 13-week inhalation study on Sprague-Dawley rats, Dept. of Toxicology, unpublished study (XXVI/352), May 30, 1978
Method: other: Chromosome Aberration Test
Genetic toxicity in vitro, IUC4#265/Ch.5.5
Gras, G. and J.-A. Rioux. 1965. Relation entre la Structure Chimique et l'Activite Insecticide des Composes Organiques de l'Etain (Essai sur les Larves de Culex pipiens pipiens L.). Arch. Inst. Pasteur Tunis. 42:9-22.
De Groot WA (2004). The chronic toxicity of bis(4-chlorophenyl) sulfone to Daphnia magna. Solvay Pharmaceuticals Int. Doc. No. 7811/0005/2004.
Seeberg, A.H., Mosesso, P., Forster, R. (1988).|High-dose-level effects in mutagenicity assays utilizing|mammalian cells in culture. Mutagenesis 3(3):213-218.
Method: other: Resembling OECD 473 (CHO), OECD 476 (V79) and OECD 482 (HeLa)
BASF AG, Department of Ecology, unpublished results, E-No.|905, J.-No. 23566, 12.12.1984
Method: other: Activated Sludge Respiration Inhibition Test following to OECD 209
Galloway S, Armstrong M, Reuben C, Colman S, Brown B, Cannon|C, Bloom A, Nakamura F, Ahmed M, Duk S, Rimpo J, Margolin B,|Resnick M, Anderson B and Zeiger E (1987). Chromosome|aberrations and sister chromatid exchanges in Chinese|hamster ovary cells: evaluations of 108 chemicals, Environ|Mol. Mutagen, Vol. 10, pp. 1-175.
Gonnet, J.F. and Guillot, J.P. (1987) Test to evaluate acute|ocular irritation and corrosivity, in the rabbit. Test|article Chlorure de neodecanoyle. Hazleton Institut Francais|De Toxicologie Rapport No 701383, dated January 26, 1987.
Steinhaueser, K.G., W. Amann, A. Spaeth, and A. Polenz. 1985. Untersuchungen zur aquatischen toxizitat zinnorganischer verbindungen. Vom Wasser. 65:203-214.
Cesarone, C.F. et al.: New Toxicology for Old, Arch. |Toxicol., Suppl. 5, 355-359 (1982)
Method: other: 8 mice, 4 h post appl. nuclei were isolated from liver and kidney cells, DNA damage was evaluated by alkaline elution technique was used, coupled with a microfluorometric method for DNA assay
Monsanto (1978) Acute Toxicity of Santoflex 13|(BN-78-1384316) to the Freshwater Alga Selenastrum|capricornutum. Unpublished study No. BN-78-362
Method: other: Algal Assay Procedure: Bottle Test (US-EPA 1971)
Lide, D.R. (ed.) CRC Handbook of Chemistry and Physics. 75th|edition. Boca Raton, FL: CRC Press, Inc., 1994-1995, in HDSB|(2001)
Bayer AG (1988). Institute of Environmental Analysis and|Evaluation. Acute fish toxicity of calcium formate tech.,|study report No. 88100359, authorized revised version dated|2 Sep 1988, unpublished.
Method: other: Draft proposal of German UBA: "Lethal effects towards zebra fish Brachydanio rerio (LC0, LC50, LC100; 48-96 h)"
BASF AG, Department of Toxicology, unpublished data,|(XXV/436), 10 Nov. 1976
Method: other: acc. to Roehrborn and Vogel, 1967
Slooff W, Canton JH (1983) Comparison of the susceptibility|of 11 freshwater species to 8 chemical compounds II.|(Semi)Chronic toxicity tests. Aquat Toxicol 4: 271 - 282
Long-term toxicity to aquatic invertebrates, IUC4#15/Ch.4.5.2
Roembke J, Bauer C, Brodesser J, Brodsky J, Danneberg G,|Heimann D, Renner I, Schallnass H-J (1995). Grundlagen fuer|die Beurteilung des oekotoxikologischen|Gefaehrdungspotentials von Altstoffen im Medium Boden -|Entwicklung einer Teststrategie (Basis for the Assessment of|the Ecotoxicological Potential of "Old Chemicals" in the|Terrestrial Environment - Development of a Testing|Strategy). Research Report UBA-FB 106 04 103, UBA Texte|53/95.
Method: other: BBA Nr. IV-4-1 part 2 adopted Dec. 1986 "Leaching in soil"
NTP (1983) Annual Plan for Fiscal Year 1983, NTP-82-119: 82
Fishman, W.H. (1940), Studies on ß-Glucuronidase, J. Biol.|Chem. 136, 229-236
Degussa AG (2006). Unpublished calculations using standard methods / equations.
Method: other: calculation with BCFWIN v2.15 as integrated in EPIWIN v3.11, Syracuse Research Center / U.S. EPA
Seinen, W. and A.H. Penninks. 1979. Immune suppression as a consequence of a selective cytotoxic activity of certain organometallic compounds on thymus and thymus-dependent lymphocytes. Ann. N.Y. Acad. Sci. USA. 320:499-517.
Method: other: Test according to Bringmann and Kuehn (cell multiplication inhibition test)
Lakhanisky Th, Hendrickx B (1985) Induction of DNA|single-strand breaks in CHO cells in culture. Prog Mut Res|5: 367-370
Method: other: alkaline sucrose sedimentation
Genetic toxicity in vitro, IUC4#119/Ch.5.5
Air Products and Chemicals (2007) MSDS on o-TDA, version 2.0 dated 4/11/2007
Melting point/freezing point, IUC4#5/Ch.2.1
Hüls AG (1984a). Akute dermale Toxizität von Isophorondiisocyanat (IPDI) für Ratten. Report No. 0289 (unpublished).
Method: other: OECD Guideline 402 (1981)
Hoechst AG (1984) Internal study No.W84-0485: Tests on|biodegradability, fish toxicity and bacteria inhibition
Toxicity to microorganisms, IUC4#210/Ch.4.4
Anon (1972). Sb. Vysledku Toxikologickeho Vyseteni Latek A|Prinpravku. P. 8. (cited in RTECS and ECDIN).
Hoechst AG (1988): Unveröffentl. Unters. (Ber.-Nr. 88.0437)
Gorzinski S.J. et al.: Butyl and Methyl Acrylate; 13-week oral toxicity studies in CDF Fischer 344 rats, Toxicologist, 2, 33, (1982)
Method: other (calculated): with the CLOGP program (Pomona College, USA)
Salmonella typhimurium TA 97, TA 98, TA 100, TA 1535, TA 1537
Foureman, P., Mason, J.M. et al., Environ. Molec. Mutagen.,|23, 51-63 (1994)
Method: other: single generation of an aerosol (0.4 ccm in ethanol, 400 l-chamber)
Daubert TE, Daner RP, Sibul HM, Stebbins CC (1984-1987).|Physical and Thermodynamic Properties of Pure Chemicals Part|4.
Melting point/freezing point, IUC4#45/Ch.2.1
Salmonella typhimurium TA 98, TA 100, TA 1535
Gelest, Inc. 1993. Material Safety Data Sheet. Tetraoctyltin - SNT7730. Issue Date: 02/05/93.
Bringmann G. & Kuehn R., Comparison of the toxicity|tresholds of water pollutants to bacteria, algae, and|protozoa in the cell multiplication inhibition test, Water|research 14, 231-241, 1980 (76)
Lagerspetz,K. et al., Comp. Biochem. Physiol.105C(3),|393-395, 1993, No information
Short-term toxicity to aquatic invertebrates, IUC4#11/Ch.4.2
Melnick R, Roycroft J, Chou B, Ragan H and Miller R (1990).|Inhalation toxicology of isoprene in F344 and B6C3F1 mice|following two-week exposures, Environ. Health Perspect.,|Vol. 86, pp. 93-98.
Bayer Industry Services (2005). Tungsten carbide (CAS-No.|12070-12-1).|Calculation of|- Vapour pressure with MPBPWIN v1.41, 2000|- Log Octanol-Water Partition Coefficient with KOWWIN v1.67,|2000 |- Henry's Law Constant with SRC-HENRYWIN v3.10, 2000|- Indirect Photodegradation with AOPWIN v1.19, 2000|- Soil Adsorption Coefficient with PCKOCWIN v1.66, 2000|- Bioconcentration Factor with BCFWIN v2.15, 2000.|- Biodegradation with BIOWIN v4.02, 2000.|- Mackay-Distribution Level I according to Mackay D., 1991.
Himejima, Kubo (1991) J. Agric. Food Chem. 39:418-421.
Ministry of Health & Welfare: Japan, Toxicity Testing Reports of Environmental Chemicals 4, 537-546 (1996)
Method: other: Comparable to OECD Test Guideline 301C, Modified MITI Test (I) (1981)
Weedon et al. (1940), cited in Environmental Health Criteria|21, WHO (1982)
Acute toxicity: inhalation, IUC4#26/Ch.5.1.2
Henne A.L., Greenlee K.W.: Am. Soc. 67, 484 (1945)
HMR Deutschland, upublished results, report No. 97.0590, |Sept. 25, 1998 (sponsored by BG Chemie Germany)
Meylan W. and Howard P. 1999. EPIWin Modeling Program.|Syracuse Research Corporation. Environmental Science Center,|6225 Running Ridge Road, North Syracuse, NY 13212-2510
Method: other (calculated): AOP Program (v1.89)
Darroudi F. & Natarajan A. T . (1985). Mutation Res. 143, 263.
Daubert TE, Danner RP (1989). Physical and Thermodynamic|Properties of Pure Chemicals: Data Compilation. Design|Insstitute for Physical Property data, American Institute of|Chemical Engineers. Hemisphere Pub. Corp, New York, NY, 4|vol.
BASF AG (1991). Department of Toxicology, sensitizing potential guinea pig, unpublished study, Project No. 30H0083/902191, 09 July 1991.
Ingram, A.J. and Grosso, P.: J. Appl. Toxicol. 5(2), 53-60|(1985);|cited in: RIFM database, location no. 2452
Repeated dose toxicity: dermal, IUC4#7/Ch.5.4
Hartenstein R (1982) Effect of aromatic compounds, humic acids and ligins on growth of the earthworm Eisena foetida. Soil Biology and Biochemistry. 14:595-599.
Toxicity to soil macroorganisms except arthropods, IUC4#1/Ch.4.6.3
Aluminosilicate Refractory Ceramic Fibres
Peripheral blood lymphocytes of Fanconi's anemia (FA) patients. FA cells show an abnormal sensitivity to the clastogenic effect of DNA cross linking agents and an increased G2 chromosomal radio sensitivity.
Hughes, T.J. et al.: Environ. Mutagen. 9, 49 (1987);|abstract 123, No information
Handbook of Environmental Data on Organic Chemicals (2001).|Fourth Edition, John Wiley & Sons Inc., New York.
Developmental toxicity / teratogenicity, IUC4#8/Ch.5.8.2
Harrington RM, Shertzer HG and Bercz JP (1986). Effects of chlorine dioxide on thyroid function in the African Green Monkey and the rat. Journal of Toxicology and Environmental Health, 19, 235-242.
Short-term toxicity to fish, IUC4#55/Ch.4.1
Jenner, P.M., Hagan, E.C., Taylor, J.M., Cook, E.L. and Fitzhugh, O.G. 1964. Food flavourings and compounds of related structure. I. Acute oral toxicity. Food and Cosmetics Toxicology 2, 327-343. Cited in: Clayton, G.D. and Clayton, F.E. (eds). 1981. Patty’s Industrial Hygiene and Toxicology, 3rd Edition, Volume IIA: Esters, p.2270
Syracuse Research Corporation. Data from SRC PhysProp Database. http://esc.syrres.com/interkow/webprop.exe?CAS=1118-46-3 (accessed December 11, 2000).
ICI Chemicals & Polymers Limited Product Safety Data: Pure|Terephthalic Acid Jan 1991
Carpenter CP et al.: Range-Finding Toxicity Data: List VIII.|Toxicol. Appl. Pharmacol. 28, 313-319 (1974)
Acute toxicity: inhalation, IUC4#12/Ch.5.1.2
Last, J. A. et al.; Inhalation Toxicology of Ammonium|Persulfate, an Oxidant Aerosol, in Rats. Toxicology and|Appl. Pharmacology, vol. 63; 257 - 263 (1982).
Meylan, M, SRC (1994-1999). AOPWIN is contained in the|computer program EPIWIN (Estimate ver.3.04), available from|Syracuse Research Corporation, Syracuse, NY, USA. Modelling|performed by ExxonMobil Biomedical Sciences, Inc.
Method: other (calculated): Calculated by AOPWIN ver.1.89
National Institute of Environmental Research (NIER), 2002, Micronucleus test of Calcium sulfate dihydrate in mouse (No. ICRC/2002/006), Tested by KOSHA, Korea.
Salmonella typhimurium TA1535, TA1537, TA1538, TA98, TA100; Saccharomyces cerevisiae D4
Cannon Laboratories Inc. (1974) The acute oral toxicity of vicinal isomer mix in rats. Reading PA Report No. 4E-4017 Air Products and Chemicals, Inc.
BASF AG, Product Safety, Cytogenetic study in vivo with|beta-Ionon R in the mouse micronucleus test, single|intraperitoneal administration, unpublished report, project|no. 26M0449/024134, 02/0449-1, 09 December 2003
FMC Corporation, Micronucleus cytogenetic assay in mice|(sodium persulfate), Study no. I90-1120, 1990.
Bates RC and Hurlbert RE (1970). The effect of acetate on|Euglean gracilis var. bacillaris as a function of|environmental conditions. J. Protozool. 17(1), 134-138.
Toxicity to microorganisms, IUC4#19/Ch.4.4
Short-term toxicity to aquatic invertebrates, IUC4#47/Ch.4.2
BASF AG (2005). Department of Product Safety,|SPARC-calculations, 22 Jun 2005, unpublished.
Natarajan, A.T. et al.: Mutat. Res. 122, 355-360 (1983), No information
Genetic toxicity in vitro, IUC4#159/Ch.5.5
FMC Corp. data, submitted to EPA June 8 (1990)
Repeated dose toxicity: oral, IUC4#120/Ch.5.4
Miller, A.J. et al.: Mutat. Res. 157, 129-134 (1985), No information
Genetic toxicity in vitro, IUC4#19/Ch.5.5
Watts J.C. (1978) Du Pont Company Data, Haskell Laboratory,|Unpublished Data:Report nø 69-79-MR nø 3025-002.
BASF AG (1968). Gewerbehygienisch-pharmakologisches|Institut. Gewerbetoxikologische Vorprüfung. Unpublished|report No. XVIII 75, dated 06 May 1968.
Atkinson,R., J. Phys. Chem. Ref. Data, Monograph 1 (1989)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer,|B., Zeiger, E. (1986). Salmonella mutagenicity tests: II.|Results from the testing of 270 chemicals. Env. Mutagenesis|8(7):1-119.
Method: other: Salmonella preincubation assay (NTP modified standard plate incorporation assay)
BASF AG (2006). Department of Product Safety, data|assessment, EPIWIN (v3.12), 06 Jan 2006, unpublished.
Fisher, T., et al, J. gen. Microbiol. 14, 238-247 (1956)
Waggy GT and Payne JR. Environmental impact produce analysis. Acute aquatic toxicity testing. Union Carbide Corporation, Research and Development Department. Project No 910F44, dated January 25, 1974.
Method: other: as described in Standard Methods for the Examination of Water and Wastewater, 13th edition, 1971.
ATOFINA Chemicals, Inc. (2001) Product bulletin for|LUPERSOL ketone peroxides.
DuPont (1974). Internal review of studies conducted both by Haskell Laboratory and other laboratories and the published literature. Submitted to Bayer AG (1974).
ABC Laboratories. Vapor Pressure of Tributyl Phosphate.|ABC Project No. 38557. (1990) (At the request of Synthetic|Organic Chemical Manufacturers Association Inc.)
Yamanaka T, Aso I, Togashi S, Tanigawa M, Shoji K, Watanabe|T, Watanabe N, Maki K, and Suzuki H (2002). Corrosion by|bacteria of concrete in sewerage systems and inhibitory|effects of formates on their growth. Water Research 36,|2636-2642.
Kenndatentabelle über Fettamine und Folgeprodukte der|Hoechst AG, Verkauf TH (Januar 1980)
Shein, S.M. et al., Anion-Radicals in Reaction of|p-Nitrochlorobenzene With Nucleophilic Reagents, Bull. Acad.|Sci. USSR Div. Chem. Sci. (Engl. Translation) 22, 1543 -|1547 (1973)
Vasil'eva, L.N. et al. (1985) Gig. Tr. Prof. Zabol., 16-19.
Bayer AG, Loeser E (1979b) Akute orale Toxizität. Short|report, October 31, 1979
Method: other: 10 rats/dose, single oral appl. by gavage, observation time: 14 days, statistical analysis
Method: other: calculated using ECOSAR (ver.0.99g)
Degussa AG (2004). Safety Data Sheet, "Diethylmalonat|(DEM)". Version 4.4, Revision date 08.07.2004, Printing date|26.07.2004
DiNardo JC, Picciano JC, Schnetzinger RW, Morris WE, Wolf BA (1985) Teratological assessment of five oxidative hair dyes in the rat. Toxicology and Applied Pharmacology 78:163-166.
Environmental Health Criteria (1987) No.74. Diaminotoluenes. WHO, Geneva. Referenced from: Buist, 1970; CRC, 1975)
Smyth H.F. Jr. et al.: AMA Arch. Ind. Hyg. Occup. Med., 10, 61-68, (1954) as cited in IUCLID.
Burrows EP, Rosenblatt DH, Mitchell WR, Parmer DL (1989).|Organic explosives and related compounds: Environmental and|health considerations. US Army Biomedical Research and|Development Laboratory, Fort Detrick, Frederick, MD.
Adsorption / desorption, IUC4#6/Ch.3.3.2
Hansch CA, Leo A, Hoeckman D (1995) Exploring QSAR|Hydrophobic, Electronic and Steric Constants. ACS|Professional Reference Book, Washington, D.C.: American|Chemical Society
CRC Handbook of Chemistry and Physics. 1979. R.C. Weast (ed.). 60th ed. CRC Press, Inc. Boca Raton, FL. p. C-713.
Chemicals Evaluation and Research Institute (CERI), Japan|(2000), Report number 20015B, Unpublished data.
Reyna MS. Two-year chronic oral toxicity study with FA 15 in|Albino rats. Report IBT No. B516-B, December 28, 1973.|Industrial Bio-Test Laboratories Inc., Northbrook, IL, USA.
Chrusciel (2005) Canadian Journal of Chemistry 83 (5):508-516)
Bayer AG: Institute of Toxicology, unpublished data, report|No. 15882, (1987)
Method: other: Richtlinine 84/449/EWG (Amtsblatt der Europaeischen Gemeinschaften Nr. L 251)
BASF AG (1979) Abt Toxikologie, unpublished report 78/186. 19.07.1979.
Soares ER and Lock LF (1980). Lack of an indication of|mutagenic effects of dinitrotoluenes and diaminotoluenes in|mice. Environ Mutagen 2, 111-124.
Method: other: evaluation within 48 hours
NTP (1992). Technical report on toxicity studies of Formic|Acid. Toxicity Report Series No. 19, NIH publication|92-3342, dated July 1992.
Ikawa M., Sasner J.J. and Haney J.F., 2001, Activity of|cyanobacterial and algal odor compounds found in lake waters|on green alga Chlorella pyrenoidosa growth, Hydrobiologia|443, 19-22
Method: other: paper disk-agar plate method
Dallas , C.E. et al.: J. Appl. Toxicol. 12, 199-203 (1992), No information
Genetic toxicity in vivo, IUC4#173/Ch.5.6
Dow Corning Corporation Internal Report Number|1982-I0065-4122-01
ACIMA AG. Akute Bakterientoxizitat. Zellvermehrungshemmtest mit Pseudomonas putida. Testsubstanz: Monooctylzinntrichlorid. 27.2.1985.
Marhold J (1986). Prehled Prumyslove Toxikol. Org. Latky,|468.
Method: other: 10 rats/dose, application of a 2 % solution, observation time 14 d, criterium: survival rate, LD50 was calculated by probit method according to Bliss, perished rats were autopsied.
CRC Handbook of chemistry and physics (1986). Weast RC (ed).|66th edition, CRC Press, Inc, Boca Raton, Florida, B.142.
BASF AG (2002). Experimental Toxicology and Ecology,|prenatal developmental study, unpublished report, Project|No. 30R0208/99142, 17 December 2002.
Benyajati, C. et al: Mutat. Res. 111, 1-7 (1983), No information
Genetic toxicity in vivo, IUC4#14/Ch.5.6
NN (1984) Phosphorus trichloride. in Henschler D.|(ed.), MAK values - harmful chemicals - toxicological and|occupational medicinal statements (original:|Gesundheitsschädliche Arbeitsstoffe -|toxikologische-arbeitsmedizinische Begründung von|MAK-Werten) Verlag Chemie Weinheim: 1 - 9|DFG (2003) Deutsche Forschungsgemeinschaft/Senatskommission|zur Prüfung gesundheitsschädlicher Arbeitsstoffe. Mitteilung|39 MAK- und BAT-Werte-Liste 2003. Wiley-VCH, Weinheim.|DFG (2000) Deutsche Forschungsgemeinschaft/Senatskommission|zur Prüfung gesundheitsschädlicher Arbeitsstoffe. Nachtrag|zur MAK-Begründung, 30. Lieferung.
Litton Bionetics Inc., Mutagenic evaluation of compound FDA|71-37, Sodium Benzoate, Food and Drug Administration,|Washington, D.C., PB 245453, 95 S. (1974)
Bushy Run Research Center (1995) Trimethoxysilane Y-4398|(TMS): Ninety-Day Vapor Exposure in Rats. Laboratory Project|ID 93N1313. January 6, 1995
Great Lakes Corporation, 1986. Data submission from Chemical|Manufacturers Association to EPA for methyl bromide. Methyl|bromide Field Dissipation Study conducted by Great Lakes|Corporation according to EPA-negotiated protocol.
Peters, P.W.J., Verhoef, A., De Liefde, A., Van Velsen,|F.L., Van Soolingen, J., De Geus, D., Danse, L.H.J., Van|Logten, M.J., 1982. Teratogenicity study of methyl bromide|by oral administration. Bilthoven, National Institute for|Public Health and Environmental Protection (RIVM report No.|618102 002) (in Dutch).
BASF AG, Material Safety Data Sheet, 1988
Sisa M, Magosh L, Ionda D, Katzi I (1959) A study of the|toxic action of p-nitrotoluol, p-nitrobenzaldoxime,|p-nitrobenzaldhyde and p-nitrophenylserine. Gig Sanit 24:|15-20
Method: other: according to Deichmann, LeBlanc, J. Industr. Hyg. Toxicol. 25, 415 (1943)
BASF AG, Department of Toxicology, unpublished data,|(XIII/27), 26 May 1964
Method: other (calculation): EPIWIN PCKOC
Adsorption / desorption, IUC4#5/Ch.3.3.2
Yalkowsky SH and Dannenfelser RM (1992) as quoted in: SRC|PhysProp Database, 17.06.2003
Salmonella typhimurium TA98, TA100, TA1535, TA1537 and Escherichia coli WP2uvrA
Chilworth Technologies, Inc (2001) PHYSICAL PROPERTIES|DETERMINATION of SILANES. Report No: R/3116RP/0201/DY K Date|February 7, 2001
Siegel H and Eggersdorfer M (1990).|3,3,5-Trimethyl-2-cyclohexen-1-one. In Ullmann's|encyclopedia of industrial chemistry, 5th Ed., Vol. A15, p.|88, VCH Verlagsgesellschaft, Weinheim.
Schoeberl (no first initial listed). 1990. Huls AbschluBberich AM-90/23 [Huls Final Report AM-90-23]. Bestimmung der Mutagen itat von Ethyldiglykolacetat im Salmonella/Sauger-Microsomen-Mutagenitatstest nach Ames Mutagenitatstest der Richtline 84/449/EWG B. 14. [Determination of the mutagenicity of diethylene glycol ethyl ether acetate in Salmonella/mammalian microsome mutagenicity test following Ames and Protocol 84/449/EWG. B.14], dated Sept. 26, 1990.
Sidgwick NV (1924). The behaviour of the simple halides with|water. J. Chem. Soc. 125, 2672-2674.
Method: other: Description of the method is not given
OECD Guideline 301 A (new version) (Ready Biodegradability: DOC Die Away Test)
Elnabarawy MT, Welter AN, Robideau RR. 1986. Relative|sensitivity of three daphnid species to selected organic and|inorganic chemicals. Environ Toxicol Chem 5: 393-398.
Hüls AG (1985). Akute dermale Toxizität von Isophorondiisocyanat (IPDI) für Ratten. Report No. 0385 (unpublished).
Monsanto Comp. data, TSCA 8d submission 86860000103 (1986)|cited in Chem. Reg. Reporter 11-13-87, 1244-1322 (1987)
Short-term toxicity to fish, IUC4#49/Ch.4.1
GESTIS - Substance Database (Information system on hazardous substances of the Berufsgenossenschaften), 14.07.2005
Eckert, J.W., Fungistatic and Phytotoxic Properties of Some|Derivatives of Nitrobenzene, Phytopathology, 52, 642-649|(1962)
Union Carbide, Chemicals and Plastics Physical Properties,|1969, No information
Walton BT, Anderson TA, Hendricks MS, Talmage SS (1989). Physicochemical properties as predictors of organic chemical effects on soil microbial respiration. Environmental Toxicology and Chemistry 8, 53-63.
Method: other: microbial respiration test
Toxicity to soil microorganisms, IUC4#20/Ch.4.4
BUA Report No. 2, o-Chloronitrobenzene, VCH, Weinheim,|October 1985
Ballantyne B (1998). In vitro genetic toxicology|investigations with 5-ethylidene-2-norbornene. Toxic|Substance Mechanisms 17, 133-151.
Hüls AG (1996). Bestimmung der akuten Wirkungen von Vestanat IPDI gegenüber Fischen. Report No. FK 1369 (unpublished).
Eastman Kodak Co. (1950) Toxicity report mucochloric acid,|August 8, 1950 (submitted to OTS by Dupont Chem. Co. with|cover letter dated 15.10.1992). Eastman Kodak Co.,|Laboratory of Industrial Medicine (unpublished data)
Brown-Woodman PDC, Huq F, Hayes L, Herlihy C, Picker K, and|Webster WS (1995). In vitro assessment of the effect of|methanol and the metabolite, formic acid, on embryonic|development in the rat. Teratology 52, 233-243.
Clariant GmbH (2001): (Study-No. TNC75353, Dr. U.|Noack-Laboratorium für angewandte Biologie) (03.05.2001)
Toxicity to terrestrial plants, IUC4#16/Ch.4.6.2
Test No. 850623, V79 CHINESE HAMSTER POINT MUTATION TEST,|CIBA-GEIGY LIMITED, unpublished report
Massaro, E.J. and Massaro, T.F. (1987) Low level lead|exposure during neonatal development perturbs cognitive|function. J. Am. Coll. Toxicol. 6(4):441-450. Cited in BIBRA|(1993)
Repeated dose toxicity: oral, IUC4#14/Ch.5.4
Report to Montefibre from May K. (1989). Dimethylacetamide:|assessment of muthagenic potential in histidine auxotrophs|of Salmonella Typhimurium (the Ames test). LSR Report|89/MTR089/0568:1-28.
Caspers N, Müller G (1993). Untersuchungen zum ökologischen|Verhalten von TINOPAL DMS. Bayer AG, Leverkusen (Germany).
Hazelton Laboratories America, Inc. (1983) sponsored |by Phillips Petroleum Company. Report No. 652-150, |Acute (LC50) Inhalation Toxicity Study in Rats, |07/06/83.
Method: other: Essentially follows OECD guideline 403
Younger FM (1962) Toxicological investigation of CP 22423 -|N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine. Younger|Laboratories, Certificate of Analysis, November 7th 1962
BASF AG, Analytical department, unpublished report, J.Nr.|6-443, 27.07.1973
Stober, Q.J., Dinnel, P.A., Hurlburt, B.F., DiJulio, D.H.|(1980); Acute toxicity and behavioural responses of coho|salmo and shiner perch to chlorine in heated sea water;|Water Res., 14, 347-354.
National Toxicology Program (1995) Salmonella Study ID|A99835 http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?|fuseaction=salmonella.salmonellaData&endpointlist=SA&|study%5Fno=A99835&cas%5Fno=999%2D97%2D3&activetab=detail
Waggy, G.T. and Payne, J.R. (1974), "Environmental Impact|Analysis Product Biodegradability Testing", Research and|Development Department, Chemicals and Plastics Union Carbide|Corporation, South Charleston, West Virginia, Report No.|910F44.
Bayer AG 1994, Internal Study, Acute toxicity of BHT to|Daphnia magna, test report 466 A/94
Method: other: Directive 67/548/EEC, C.2 "Acute Toxicity for Daphnia" (1992)
Falbe J. & Regitz M., Römpp Lexikon Chemie, 10. Edition,|Volume 6, p. 4522, (1999)
Method: other: Federal Hazardous Substance Labeling Act (FHSLA), Federal Register Aug 12, 1961, p 7333-7341, Part 191 "Hazardous Substances Definitions and Procedural and Interpretative Regulations, Final Order"
Ministry of Health and Welfare (1999) Reverse mutation test|of 1-chloro-2 (chloromethyl)benzene on bacteria. Japan|Toxicity Testing Reports of Environmental Chemicals,|7,503-508.
BASF AG, department of ecology, unpublished data|(00/0359/60/1), 30.03.2001
Beilstein Handbook of Organic Chemistry (1950-1959) E IV 4/5|p. 4014.
Chemical Industry Institute of Toxicology. Toxicology data|assessment report. Executive summary. [Summary of audit|report prepared for the CIIT by Experimental Pathology|Laboratories, CIIT Docket]. CIIT, Research Triangle Park,|NC. (1983).
Method: other: in general conformance with OCD 453
Bartlett et al.. (1981) "Evaluation of the toxicity of DOWANOL* PM to representative aquatic organisms", unpublished report of the Dow Chemical Company.
Boublik T, Fried V, Hala E (1984) The Vapour Pressures of|Pure Substances; Selected Values of the Temperature|Dependence of the Vapour Pressures of some Pure|Substances in the Normal and Low Pressure Region. Amsterdam,|New York, Elsevier Scientific Pub. Co.
Method: other: 2-stage (initiator/promoter) carcinogenesis test
Eastman Chemical Company 2004 Product Data Sheet for diethylene glycol butyl ether acetate (DGBEA) on line at www.eastman.com.
Short-term toxicity to fish, IUC4#15/Ch.4.1
Klopman G, Namboodiri K, and Schochet M (1985). Simple|method of computing the partition coefficient. J.|Computational Chem. 6(1), 28-38.
Ishikawa, S. et al., Suishitsu Odaku Kenkyo Tokyo 8, 799-807 (1985)
BASF AG, Laboratory of Ecology, unpublished data, 05.04.1979, No information
Method: other: Toximeter experiments (model WWTP)
Toxicity to microorganisms, IUC4#12/Ch.4.4
Biodegradation and Bioaccumulation Data of Existing|Chemicals Based on the CSCL Japan, Compiled under the|Supervision of Chemical Products Safety Division, Basic|Industries Bureau MITI, Ed. by CITI, October 1992.|Published by Japan Chemical Industry Ecology-Toxicology|& Information Center
Moodie RB, Stephens RJ (1987) Electrophilic Aromatic|Substitution. Part 33. Kinetics and Products of Aromatic|Nitrations in Solutions of Dinitrogen Pentaoxide in Nitric|Acid. J Chem Soc Perkin Trans 2: 1059 - 1064
Suzuki J, Koyama T, Suzuki S (1983) Mutagenicities of|mono-nitrobenzene derivatives in the presence of norharman.|Mut Res 120: 105-110
Method: other: according to Yahagi, Tanpakushitsu Kakusan Koso 29, 1178 (1975)
Dow Corning Corporation Internal Report Number|1982-I0065-4122-09
Adsorption / desorption, IUC4#4/Ch.3.3.1
Huels AG (1989). Unpublished study report #1580. Cited in:|ECB IUCLID 2000.
FMC Corp. Data, TSCA 8d Submission 86860000116 (1976) cited|in Chem. Reg. Reporter 11-13-87, 1244-1322 (1987) and cited in BIBRA Toxicity Profile (1991).
Acute toxicity: inhalation, IUC4#50/Ch.5.1.2
BASF AG, Analytical Department; unpublished data (Fixapret |CPN 45%); (J.Nr. 12501; 22.07.74)
EU Method C.5 (Degradation: Biochemical Oxygen Demand)
CIIT (1993) A chronic inhalation toxicity study of chlorine|in female and male B6C3F1 mice and Fisher 344 rats, Report,|December 1993
Method: other: essentially follows Combined Chronic Toxicity/Carcinogenicity Study Guideline
Spivack, J.L., E.R. Pohl, and P. Kochs. 1997. |Organoalkoxysilanes, organosilanols, and organosiloxanols,|in G. Chandra (ed.), The Handbook of Environmental|Chemistry, Vol. 3, Part H, Organosilicon Materials. |Springer-Verlag, Berlin, p 105.
Geigert, J., Lee, T. D., Dalietos, D. J., Hirano, D. S.,|Neidleman, S. L. (1986). Epoxidation of alkens by|chloroperoxidase catalysis. Biochem. and Biophysi. Res. Com.|136, 778-782
Dutch Institute for Working Conditions (1993/1994); chemistry cards, data for safe work with chemicals, 9th Edition.
Ciba-Geigy Ltd., Acute aerosol inhalation toxicity in the|rat of TK 10044, Project No 444278; 11.9.1978.
Method: other: Sachsse et al. Proc. Europ. Soc. for the study of drug toxicity, 1973, and Chemische Rundschau, 1976
Tsuda, T., H. Nakanishi, S. Aoki, and J. Takebayashi. 1988. Bioconcentration and metabolism of butyltin compounds in carp. Wat. Res. 22(5):647-651.
Gupta RL, Gupta AK, Pathak DP, and Juneja TR (1987)|Mutagenic Studies of o-toluidine and its potential|metabolites. Indian J Exp Biol 25: 618-622
Method: other: according to Ames et al., Mutat. Res. 31, 347 (1975)
Genetic toxicity in vitro, IUC4#22/Ch.5.5
Litton Bionetics (1977) Mutagenic evaluation of compound FDA|75-69.000067-48-1, choline chloride, FCC. Report No. PB-266|891, Mar. 1977
Method: other: comparable to OECD Guide-line 471
Kitaeva, L.V. et al.: Tsitologia (Moskva) 32, 1212-1216|(1990)(translated from Russian), No information
Method: other: in vivo chromosomal aberrations - mammals (bone marrow cells and embryos)
Genetic toxicity in vivo, IUC4#65/Ch.5.6
Letz, G., Wugofski, L., Cone, J.E., et al. 1987. |Trimellitic anhydride exposure in a 55-gallon drum|manufacturing plant: clinical, immunologic, and industrial|hygiene evaluation. American Journal of Industrial|Medicine. 12: 407-417.
Schering AG. 1989. Genetic Toxicology: In vitro Mammalian Cell HGPRT Test - Fh-ITA Study No. G89/1. Study conducted by Fraunhofer-Gesellschaft Institut fur Toxikologie und Aerosolforschung. 31.05.1989.
Method: E12-06:Growth inhibition test according to Bringmann-Kühn; DIN 38412/8 (Draft)
Myhr, B.C., Caspary, W.J. (1988). Evaluation of the L5178Y|mouse lymphoma cell mutagenesis assay: Intralaboratory|results for sixty-three coded chemicals tested at Litton|Bionetics, Inc. Env. Molecular Mutagenesis. 12(13):103-194.
Short-term toxicity to fish, IUC4#59/Ch.4.1
Ishidate, Jr. M. et al., Primary mutagenicity screening of|food additives currently used in Japan, Fd. Chem. Toxic.|22(8), 623-636, 1984 (85).
Genetic toxicity in vitro, IUC4#68/Ch.5.5
Hoechst AG (1975) Akute dermale Toxizitaet von|Nitro-o-dichlorbenzol-4,1,2 an weiblichen SPF-Wistar-Ratten|(unpublished report no. 500/75). Hoechst AG, Frankfurt
Gocke E, King MT, Eckhardt K, Wild D (1981) Mutagenicity of cosmetics ingredients. Mutation Research 90:91-109.
Merck chemical catalogue 1992/1993, S. 246.
Acute toxicity: dermal, IUC4#28/Ch.5.1.3
BASF AG (2006). Department of Product Safety, data|assessment, EPIWIN (v3.12), 05 Jan 2006, unpublished.
Method: other (calculated): KOWWIN (v1.67)
Wellborn, T.L.Jr.: Prog. Fish Cult. 31, 27-32 (1969), No information
Short-term toxicity to fish, IUC4#172/Ch.4.1
Genetic toxicity in vitro, IUC4#110/Ch.5.5
USEPA. 2000. KOWWIN. Version 1.67. Estimation Programs Interface (EPI) Suite. Office of Pollution Prevention Toxics (OPPTS) and Syracuse Research Corporation.
Rampy, L.W. (1973) Environmental Health Services Project|Number NBS-034. Unpublished Dow Chemical Company Report
BASF AG, Safety data sheet Sicotan Gelb L 2011, 02.10.2000
US Environmental Protection Agency (1991) Registration|eligibility document (RED). Sodium Diacetate. US|Environmental Protection Agency.
BASF AG, Department of Toxicology, unpublished study|(XVI/299), 20.12.66
Merck; The Merck Index; 10 ed.; Merck and Co., Inc., Rahway,|New Jersey (1983).
Method: other: according to Federal Register 38, No. 187, § 1500.41, S. 27019, 27. Sept. 1973
GESTIS (2006). Database (Gefahrstoffinformationssystem der|gewerblichen Berufsgenossenschaften). Available online at|http://biade.itrust.de/biade/lpext.dll?f=templates&fn=main-h|.tm, request of 05 Oct 2006.
Appearance/physical state/colour, IUC4#5/Ch.1.1.1
Malek DE, Malley LA, Slone TW, Elliott GS, Kennedy GL,|Mellert W, Deckardt K, Gembardt C, Hildebrand B, Murphy SR,|Bower DB, Wright GA (1997) Repeated dose toxicity study (28|Tags) in rats and mice with N-Methylpyrrolidone (NMP), Drug|Chem Toxicol, 20, 63-77
Method: other: Directive 92/69/EEC, B.7 and OECD 407
Method: other: 10 mice/sex/dose group, observed for mortality, body weight, clinical signs, feed consumption; complete necropsy performed on all rats
OECD Guideline 112 (Dissociation Constants in Water)
Kuehn R, Pattard M, Pernak KD, Winter A (1988)|Schadstoffwirkungen von Umweltchemikalien im|Daphnien-Reproduktions-Test als Grundlage fuer die Bewertung|der Umweltvertraeglichkeit in aquatischen Systemen. UFOPLAN|Nr. 10603052 des BMU
Method: other: Provisional procedure proposed by the Federal Environmental Agency for extended toxicology with Daphnia magna (01.01.1984)
Chemicals Evaluation and Research Institute (CERI). (2002).|Biodegradation Study on MMB, Report Number 13847.|Unpublished Report.
OECD Guideline 302 C (Inherent Biodegradability: Modified MITI Test (II))
Wellens, H.: Z. Wasser-Abwasser Forsch. 15, 49 (1982)|cited in: IPCS Environ. Health Crit. 89, (1989), No information
Short-term toxicity to fish, IUC4#37/Ch.4.1
Flyvholm, M.-A., Menne, T. (1990): Contact Dermatitis 23,|341 - 345
Vighi M, Gramatica P, Consolaro F, Todeschini R (2001) QSAR|and Chemometric Approaches for Setting Water Quality|Objectives for Dangerous Chemicals. Ecotox Environ Safety|49: 206 - 220
Method: other: tested with standard EEC or OECD methods or comparable
Short-term toxicity to fish, IUC4#130/Ch.4.1
Novogrodsky A. et al. Hydroxyl radical scavengers inhibit|lymphocyte mitogenesis. Proc. Natl. Acad. Sci. USA,|79:1171-1174, 1982 (111).
Klimmer OR (1965). Toxikologische Prüfung von IPD und TMD,|Institut für Pharmakologie der Universität, Bonn|(unpublished study report for Scholven-Chemie AG).
Method: other: The undiluted substance was applied to the depilated back skin, massaged into the skin by means of a glass rod and covered with gauze and adhesive tape ("Leukoplast") (duration of the occluded exposure not reported).
Hoff N. 28-day oral toxicity (gavage) study with FAT|65'023/L in the rat. Report RCC Project No. 288505,|September 26, 1991. RCC Research & Consulting Company AG,|Itingen Switzerland.
Anderson, R.C. et al., Toxicological Studies On Synthetic|Glycerin, J. of the Am. Pharm. Ass. 39, 583-585, 1950 (30).
Bayer AG data, Report No. 19232, 6. 7. 1990
Chemicals Evaluation and Research Institute (2005). 4-Ethyl|morpholine. Calculation of|- Vapour pressure with MPBPWIN v.1.41, 2000|- Log Octanol-Water Partition Coefficient with KOWWIN v.|1.67, 2000|- Indirect Photodegradation with AOPWIN v. 1.91, 2000|- Henry�Ls Law Constant with HENRYWIN v. 3.10, 2000|- Soil Adsorption Coefficient with PCKOCWIN v. 1.66, 2000|- Bioconcentration Factor with BCFWIN v.2.15, 2000|- Water Solbility with WSKOW v1.41, 2000|- Stability in Water with HYDROWIN v1.67|- Mackay-Distribution with Level III Fugacity Model, 2000.
Method: other (calculated): Estimated value with AOPWIN v. 1.91
de Wolf, J.M. and R. Schilt. 2005. Abiotic degradation of butyltrichlorostannane (MBTC, CAS # 1118-46-3) according to OECD Test guideline 111 - a preliminary test (Tier 1). TNO Quality of Life. TNO Report V6017. February 8, 2005.
Appel, M.J. and D.H. Waalkens-Berendsen. 2004. Trichloromethylstannane [CAS # 993-16-8]: Sub-chronic (13-week) oral toxicity study in rats, including a reproduction/developmental screening study. TNO Nutrition and Food Research. TNO Report V4929, July 2004.
Emmons, W. W., Marks, J. G.: Contact Dermatitis 13, 258-265|(1985)
Nagasawa H, Fujimoto M. (1973) Experimentia 29, 89. Cited in|BIBRA Toxicity Profile 1995
Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537
Younger Laboratories Inc. (1977). Toxicological|investigation of dicyclohexylamine (at the request of|Monsanto CO). EPA OTS 0545785.
Method: other: 4 dose groups; 5 rats/group (158, 251 mg/kg: 2 males and 3 females; 200, 316 mg/kg: 3 males and 2 females); TS undiluted; post application observation period: 14 days, record of signs of intoxications, gross autopsy
Method: other: substantially saturated vapor inhalation
Tulhoff H (2000). Carbides. Metal like carbides of|industrial importance. Ullmann´s Encyclopedia of Industrial|Chemistry (electronic edition). Wiley-VCH Verlag, Weinheim.
Solubility in organic solvents / fat solubility, IUC4#20/Ch.2.6.1
Zeiger, E. et al., Environ. Mutagen. Molec. Mutagen. |16 (Suppl. 18), 1-14 (1990)
Microbiological Assoc. data, Project No. T9145.105011,|August 20 (1991) (At the repuest of Synthetic Organic|Chemical Manufactureres Association Inc.)
Method: other: U.S. EPA TSCA Test Guideline 798.5385
Blondeel, A. et al. (1978), Contact allergy in 330|dermatological patients, Contact Dermatitis 4, 270-276
Method: other: Fregert et al, Epidemiology of contact dermatitis. Transactions of the St. John´s Hospital Dermatological Society 55, 17-35, 1969.
Das, A.: Mycopathol. Mycolog. Appl. 49, 205-207 (1973), No information
Genetic toxicity in vitro, IUC4#62/Ch.5.5
Du Pont (1988), DIMETHYLACETAMMIDE: Properties, Uses,|Storage and Handling. Printed in U.S.A.:1.
Genetic toxicity in vivo, IUC4#60/Ch.5.6
BASF AG (1999) Department of Toxicology, project No.|17F0504/965150, 16 Feb 1999, unpublished.
Metaphase analysis of Chinese hamster ovary (CHO) cells
BGVV/UBA (Eds.) (1995). Bewertung der Gefaehrdung von Mensch|und Umwelt durch ausgewaehlte Altstoffe. Umweltbundesamt,|UBA Texte 38/95.
Zhao Y-H, Yuan X, Ji G-D, Sheng L-X, Wang L-S (1997)|Quantitative Structure-Activity Relationships of|Nitroaromatic Compounds to Four Aquatic Organisms.|Chemosphere 34 (8): 1837 - 1844
Method: other: comparable to OECD 202 part 1 (Daphnia: Acute toxicity, 1984)
Miyakawa, Y. et al. (1986): Toxicol. Lett. 34, 99 - 105
Repeated dose toxicity: dermal, IUC4#29/Ch.5.4
CIBA-GEIGY Limited. 1981. Report on Acute Dermal LD50 in the Rat of TK 10.701. Project No. 810905. September 17, 1981.
Method: other: similar to OECD Guide-line 402
Knezovich JP and Crosby DG (1985). Fate and metabolism of|o-toluidine in the marine bivalve olluscs Mytilus edulis and|Crassostrea gigas. Environ. Tox. Chem. 4, 435-446.
Solubility in organic solvents / fat solubility, IUC4#0/Ch.2.6.1
ELF ATOCHEM S.A.(1995a) Thioglycolate d'isooctyle,|détermination de la biodégradabilite facile, essai de|dégagement du CO2. Centre d'Application de Levallois, étude|n° 4177/95/A, 19/12/1995.
ACIMA AG. 1985. Akute Bakterientoxizitat. Zellvermehrungshemmtest mit Pseudomonas putida. Testsubstanz: Dioctylzinndichlorid. 26.2.1985.
Hoechst AG (1992) Mitteilung der Abt. UWS-Ökologie (28.08.1992); nachträglich erstellte Untersuchungsberichte über unveröffentlichte Untersuchungen aus den Jahren 1975, 1980 und 1982.
Method: other: Zahn-Wellens-Test in accordance with DIN 38412, Part 25
Biodegradation in water: screening tests, IUC4#15/Ch.3.5
Method: other: 20 mg or more were applied to rabbit skin. No further details
Gentile J.H. et al., (1976): Power plants, chlorine and|estuaries, Ecol. Res. Ser., EPA-600/3-76-055,|Env.Res.Lab.Govt. Rep. Announce. Index 76(21), US NTIS PB|255 957, US EPA , Narragansett, RI : 39pp.
BASF AG, department of ecology, unpublished data (1313/89),|21.12.1989
Method: other: 79/831/EWG, Annexe V, p. C
Smith, E.R.B. (1942) A comparison of the effects of large|doses of calcium gluconate-idonate, calcium gluconate, and|calcium chloride. J. Lab. Clin. Med., 25, 1018-1021.
Allied Chemical: Report No. MA-03-77-4, Februar 1979
Food & Drug Research Laboratories (1973). Teratologic|evaluation of FDA 71-72 (glucono-delta-lactone). Unpublished|data, contract No FDA71-260, FDRL, Maspeth,NewYork, USA.
Hoechst AG (1983): Unpublished study. BONS TTR. Prüfung auf|akute Reizwirkung / Ätzwirkung am Auge beim Kaninchen (in|German) (Ber.-Nr. 83.0515), 6 Oct 1983
SRC. 2001. Atmospheric Oxidation Program for Microsoft|Windows (AOPWIN). Syracuse Research Center.
Method: other (measured): Estimated - AOPWIN
Stober, Q.J., Hanson, C.H. (1974); Toxicity of chlorine and|heat to pink (O. gorbuscha) and chinook salmon (O.|tshawytscha); Trans. Amer. Fish. Soc., 3, 569-576.
Short-term toxicity to fish, IUC4#33/Ch.4.1
Becci, P.J., Knickerbocker M.J. , Reagan E.L., Parent R.A.,|Burnette L.W. (1982) Teratogenicity study of|N-methylpyrrolidone after dermal application to|Sprague-Dawley rats, Fundam. Appl. Toxicol., 2, 73-76
Kuhn EP and Suflita JM (1989). Anaerobic biodegradation of|nitrogen-substituted and sulfonated benzene aquifer|contaminants. Haz. Waste Haz. Mat. 6(2), 121-133.
Method: other: according to Kuhn and Suflita. Haz. Waste Haz. Mat. 6(2), 121-133
Biodegradation in water: screening tests, IUC4#180/Ch.3.5
Hoechst AG. 1992. Interne Berechnung der Abt. [Internal determination in the division] UCV (11.05.1992)
Method: other (calculated): according to Atkinson
Appelman, L. M., Woutersen, R. A., Zwart, A., Falke, H. E.,|and Feron, V. J. (1988). One-year inhalation toxicity study|of formaldehyde in male rats with a damaged or undamaged|nasal mucosa. J. Appl. Toxicol., 8, 85-90., No information
Salmonella typhimurium TA98, TA 100, TA 1535, TA 1537, TA 1538
Mitsubishi Gas Chemical Company, Inc. (2002) Material Safety Data Sheet
MOE (Ministry of the Environment), Japan. (2003) |Ecotoxicities of p-Toluic acid to freshwater organisms (freshwater fish, daphnids and algae). Unpublished Data
Lide DR (2003). CRC Handbook of Chemistry and Physics. 84th|Edition. CRC Press Boca Raton, London, New York, Washington,|2003-2004.
Krul, C.A.M., Bacterial reverse mutation test with Butyltrichlorostannane. Report V 3405/23. Department of Biomolecular Sciences, TNO Nutrition and Food Research, 3700AJ Zeist, The Netherlands. 28 March 2002.
Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B and|Zeiger E (1986). Salmonella Mutagenicity Tests: II. Results|from the testing of 270 chemicals. Environmental Mutagenesis|8, Suppl. 7, 1-119
Method: other: according to Haworth et al. (1983) and Zeiger and Drake (1980)
Kamiya, A. and Ose, Y.: Sci. Total Environ. 78, 131-145|(1989)
Method: other: according to Kamiya, A. and Ose, Y.: Sci. Total Environ. 65, 109-120 (1987)
Ishidate M Jr, Sofuni T (1985) The in vitro chromosomal|aberration test using Chinese hamster lung fibroblast cells|in culture. Prog Mut Res 5: 427-432
Method: other: Chromosomal aberration test according Ishidate and Odashima 1977
Steffensen IL, Paulsen JE, Alexander J (1997) Induction of|aberrant crypts in mouse, but not in rat colon by|mucochloric acid, a genotoxic hydroxyfuranone found in|chlorinated drinking water. Proc American Assoc Cancer Res. |Carcinogenesis 38: 469
Method: other: Detection of aberrant crypt foci and intestinal tumours after initiation with 1,2-dimethylhydrazine and treatment with MCA
Melting point/freezing point, IUC4#18/Ch.2.1
Gizhlaryan, M. S. et al. (1984) Gig. Tr. Prof. Zabol., 0, 45-47.
Ema, M., T. Itami, and H. Kawasaki. 1992. Susceptible period for the teratogenicity of di-n-butyltin dichloride in rats. Toxicol. 73:81-92.
Juhnke I. & Luedemann D., Ergebnisse der Untersuchung von|200 chemischen Verbindungen auf akute Fischtoxizitaet mit|dem Goldorfentest, Z.f. Wasser- unde Abwasser-Forschung 11|(5) 161-164, 1978 (71)
Gerike,P., Gode,P., Chemosphere 21, 799-812, 1990, No information
Method: other: Respiration Inhibition Test, modified
Toxicity to microorganisms, IUC4#14/Ch.4.4
Chou CC, Que H, and Shane S (1992). Microtox EC50 values for|drinking water by-products produced by ozonolysis.|Ecotoxicology and Environmental Safety 23(3), 355-363.
METI, Japan (2000). Ministry of Economy, Trade and Industry (formerly MITI), unpublished data, conducted by Chemicals Evaluation and Research Institute (CERI, Japan) Test No.: 53426, 5265, 20132
EPA (1985) "Ambient Water Quality Criteria for Chlorine -|1984", Environmental Protection Agency, EPA 440/5-84-030
Short-term toxicity to fish, IUC4#56/Ch.4.1
Meier et al. (1985). Evaluation of chemicals used for|drinking water disinfection for production of chromosomal|damage and sperm-head abnormalities in mice. Environ.|Mutagen., 7,p 201-211.
Aftring RP, Chalker BE, Taylor BF. (1981) Degradation of|phthalic acids by dentrifying mixed cultures of bacteria.|Appl Environ Microbiol 41, 1177-83
Biodegradation in water: screening tests, IUC4#49/Ch.3.5
Griffith JF (1973). Fluorescent whitening agents. Tests for|skin-sensitizing potential. Arch. Dermatol. 107, 728 - 733.
Bayer AG: Safety Data Sheet (2001-07-19)
Satler, S.D., and Thimann, K.V. 1980. The Influence of|Aliphatic Alcohols on Leaf Senecences. Plant Physiol., 66:|395-399. As cited in World Health Organization (WHO). 1987.|Environmental Health Criteria 65: Butanols - Four Isomers:|1-Butanol 2-Butanol tert-Butanol Isobutanol. WHO.
Toxicity to terrestrial plants, IUC4#30/Ch.4.6.2
CERI. (2004) Measurement of melting point of p-toluic acid.
Ross, W.E. and Shipley, N.: Mutat. Res. 227-283 (1980), No information
Genetic toxicity in vitro, IUC4#215/Ch.5.5
Monsanto Co (1977b) Unpublished data: cited in ACGIH (1986)|Documentation of TLVs, 5th ed., pp. 432.1-432.2
The Merck Index, Tenth Edition, p. 604, 1983, No information
Bayer AG (1986). 2,4-Dinitrololuene, 2,5-Dinitrololuene,|2,6-Dinitrololuene: Calculated vapour preasures. Unpublished|report 682162.
Method: other (measured): vapour pressure weighing machine
Howard PH (1989) Handbook of Environmental Fate and Exposure|Data. Vol. 1 Large Production and Priority Pollutants,|73-77. Lewis Publ. Chelsea
Smyth H.F. Jr et al. (1951) Archs Ind Hyg (4) 119. Cited in|BIBRA (1993)
Bringmann G, Kühn R (1980) Bestimmung der biologischen|Schadwirkung wassergefährdender Stoffe gegen Protozoen II.|Bakterienfressende Ciliaten. Z Wasser Abwasser Forsch 1980|(1): 26 - 31
Toxicity to microorganisms, IUC4#45/Ch.4.4
BASF AG, (1979) n-Butyl Acrylate: Prenatal inhalation toxicity in the rat, Dept. of Toxicology, unpublished study, (78/638), July 30, 1979
Method: other: Guidelines for reproduction studies for safety evaluation of drugs for human use, FDA, Jan., 1966 and Guidance on reproduction studies from the Association of the British Pharmaceutical Industry, 1975
Ciba (1991a). Growth Inhibition Test of Metilox (TK 10027)|to Green Algae (Scenedesmus subspicatus). Unpublished report|# 918011. March 18, 1991.
Chou BJ, Leach CL, Miller RA, Horstman MG, Ragan HA, Bucher|JR, Roycroft JH (1991) 13-week subchronic inhalation|toxicity of 4-chloronitrobenzene (4-DCB) in rodents. The|Toxicologist 11: 87 Abstr. 262
Method: other: 10 mice/sex/group, whole body exposure, see also freetext ME
Kretzschmart HJ, Neyen V (1992) HPLC-Analyse von|N-Phenyl-N´-(1.3-dimethylbutyl)-p-phenylendiamin (6PPD) im|Migrat von Gummi-Bedarfsgegenstaenden. Deutsche|Lebensmittel-Rundschau 88 (12): 387 - 390
Chapin, R.E., White, R.D., Morgan K.T., and Bus, J.S.:|Toxicol. Appl. Pharmacol. 76:328-343 (1984).
MOE, Japan (1996) Ministry of Environment: unpublished report of reproduction inhibition study of N-tert-butyl-2-benzothiazonylsulphenamide to Daphnia magna.
Adsorption / desorption, IUC4#5/Ch.3.3.1
BASF AG, Product Safety, 6-Methylhept-5-en-2-one|(methylheptenon) - Prenatal developmental toxicity study in|Wistar rats, oral administration (gavage), unpublished|report, project no. 30R0874/00111, 00/874, 29 Oct. 2002
Syracause Research Corporation, Environmetal Science Center (2002)
Kirk-Othmer Encyclopedia of Chemical Technology, 4th|edition, 1991
BASF AG (1994). Department of Analytical Chemistry, report|BRU 94.296, 24 Jun 1994, unpublished.
Moskalenko (1966): Vopr. Kommunal. Gig. 6: 89-94
Sato K, Ichimasa M, Kiyahara K, Shiomi M, Nishimura Y and|Ichimasa Y (1999). Radioprotective effects of sodium|tungstate on hematopoietic injury by exposure to|60Co-gamma-rays in Wistar rats. J Radiat Res 40, 101-113.
Heukelekian,H., Rand,M.C., JWPCA 27, 1040-1053, 1955, No information
BOD5 Method: other: Standard Dilution Method
Scopas Technology Company (1984). Mutagenicity evaluation of|chlorine dioxide in the mouse bone marrow cytogenetic assay.| Litton Bionetics Inc, report n°= 22202.
EPA OTS 798.5385 (In Vivo Mammalian Cytogenetic Tests: Bone Marrow Chromosomal Analysis)
Merck AG (2004). Material safety data sheet according to|91/155/EEC, last update 02 Feb 2004.
Genetic toxicity in vivo, IUC4#63/Ch.5.6
NCR "Formaldehyde: An assessment of its health effects";|Washington DC, National Research Council Report|NAS/ACT/P-881A, (1980);|cited in: IPCS Environ. Health Crit. 89, (1989), No information
Method: other: calculated with SRC - BCFWIN v2.15
Shimizu et al. (1985): The results of microbial mutation|test for forty-three industrial chemicals. Sangyo Igaku|(Jpn. J. Ind. Health) 27, 400-419
BASF AG, Analytical Institute, unpublished data, Determination of the partition coefficient log Pow of n-butyl acrylate, (J.Nr.129304/03), 08-29-1988
Chemicals Evaluation and Research Institute (CERI). (2001).|Report of Water Solubility Measurement of MMB, Report Number|81948. Unpublished Report.
BUA (1991). Chemical Report No. 81, August 1991: Formic|acid, formates. Edited by Beratergremium für umweltrelevante|Altstoffe|(BUA) der Gesellschaft Deutscher Chemiker. VCH Publishers,|Weinheim, Germany.
Method: other: German Industrial Standard DIN 38412, part 15
Gvozdak, L.I. et al., The Microbial Removal of|p-Nitrochlorobenzene From Water Under Anaerobic Conditions,|Khimiya i Tekhnologiya Vody 4, 473-474 (1982)(english|translation from 1983)
Method: other: anaerobic flow-through apparatus
BASF AG, Labor Oekologie; unveroeffentlichte Unter-suchung cited in IUCLID (2000)
U.S. National Library of Medicine, 2006. Hazardous Substance Data Bank (HSDB). http://toxnet.nlm.nih.gov/cgi-bin/sis/search
Moffitt AE, Clary JJ, Lewis TR, Blanck MD, Perone VB. (1975)|Absorption, distribution, and excretion of terephthalic acid|and dimethyl terephthalate. Amer Ind Hyg Assoc J 36, 633-641
National Institute of Environmental Research (NIER), Korea, Growth Inhibition Test of Calcium sulfate dihydrate to algae (Report No. EG02079, tested by KRICT), 2003
Toxicity to aquatic algae and cyanobacteria, IUC4#19/Ch.4.3
Biesinger, K., Christensen, G.L. (1972). Effects of various|metals on survival, growth, reproduction and metabolism of|Daphnia magna. J. Fish. Res. Bd. Canada 29:1691-1700.
TSCATS: OTS 0535413, Doc.I.D. 86-920000855S, 3/20/92, Letter submitting multiple studies on multipel chemicals required for docket OPTS-82036 with attachments,DOW CHEM CO, 1992
Repeated dose toxicity: inhalation, IUC4#18/Ch.5.4
Carere, A. et al., Prog. Mutat. Res. 5, 307-312 (1985)
Bandman et al. (1993). Vrednie chemichescie veshestva.|Neorganicheskie seodinenia elementov V-VII groopp (Hazardous|substances. Inorganic substances containing V-VII goup|elements) Chimia 1989 P. 71.
BASF AG, Department of Toxicology, Ergebnis der|gewerbetoxikologischen Vorprüfung, unpublished report|(XXIII/401), 04 Sept. 1974
Cesarone CF, Fugassa E, Gallo G, Voci A, Orunesu M (1984)|Influence of the culture time on DNA damage and repair in|isolated rat hepatocytes exposed to nitrochlorobenzene|derivatives. Mutation Research 131: 215-222
Method: other: alkaline elution assay, (1) cell culture 1.5 hrs, then 3 hrs treatm.(5,50 uM), determ. of elution rate (ER) 3, 24 and 48 hrs post treatm.; (2) cell culture: 24 hrs, then 3 hr- treatm.(50uM), ER 3, 24 and 48 hrs post treatm.
Obe, G. and Beek, B.: Drug and Alcohol Dependence 4, 91-94|(1979), No information
Genetic toxicity in vitro, IUC4#160/Ch.5.5
Yamamoto, R.S., Frenkel H.H, Weisburger. Effects of isomers of acetotoluidide and aminobenzoic acid on the toxicity and carcinogenicity of N-2-fluorenylacetamide. Tox. Appl. Pharm. 17, 98-106, 1970
Maurer, T. et al.: Toxicology 69, 209-218 (1979), No information
ABC Lab Inc. (1990). Acute flow-through toxicity of sodium|formate to fathead minnow (Pimephales promelas). Analytical|Biochemistry Laboratories Inc., report No. 38313 for Hoechst|Celanese Corp., 16 March 1990, unpublished.
EPA OTS 797.1400 (Fish Acute Toxicity Test)
Myers R.C. & Ballantyne B. (1997). Comparative acute toxicity|and primary irritancy of various classes of amines. |In: Toxic Substance Mechanisms, Vol. 16, 151-193, Taylor &|Francis (1997).
FMC Corporation, Acute toxicity of sodium persulfate to|bluegill (Lepomis macrochirus), Study no. I92-1250, 1993.
APCI, Dabco Catalyst; Toxicity Studies On, unpublished|studies, APCI RRRS EXT-80/014, 27 May 1980
Worksafe Australia (1995) NATIONAL INDUSTRIAL CHEMICALS|NOTIFICATION AND ASSESSMENT SCHEME FULL PUBLIC REPORT|ISOBUTYLTRIETHOXYSILANE File No: NA/246 Date: 8 March 1995
Feron, V.J. et al.: Cancer Lett. 39, 101-111 (1988), No information
Repeated dose toxicity: inhalation, IUC4#13/Ch.5.4
BASF AG, Experimental Toxicology and Ecology, unpublished study, Isobutylacrylat - Determination of the biodegradability in the CO2-Headspace Test, 01/0366/27/1, 06 September 2001
Method: other: CO2 headspace test (ISO 14593)
Liden, L.W., Burton, D.T. (1980): Effects of|chlorobrominated and chlorinated cooling waters on estuarine|organisms. J. WPCF, 52(1), 173-182.
Long-term toxicity to fish, IUC4#3/Ch.4.5.1
Bakhishev, G.N.: Farmakol. Toksikol. 8:140-2 (1973).
Waggy, G.T. and Raghuram, M. (1991) Ecological fate and|effects data on selected amine products. Unpublished UCC|report.
CIT (2003) Study number 24184. Determination of the abiotic|degradation (hydrolysis as function of pH) with IOTG.
Brown-Woodman PDC, Webster WS, Huq F, Herlihy C, Hayes LC,|and Picker K (1995). Induction of birth defects by exposure|to solvents: an in vitro study. Teratology 51: 288.|(Presented to the Australian Teratology Society, Melbourne,|1994).
Flury F. and Zernik F. (1931): Harmful Gases, Vapours, Fok,|Smoke and Dust Varieties. J. Springer Publishing House,|Berlin, 117-121
Acute toxicity: inhalation, IUC4#29/Ch.5.1.2
Long-term toxicity to aquatic invertebrates, IUC4#11/Ch.4.5.2
BASF AG, Product Specification THIODIGLYCOL ULTRA,|17.06.2002
Plank JB. 90-day subacute oral toxicity study with FA-15 in|Albino rats. Report IBT No. B9451, June 22, 1971. Industrial|Bio-Test Laboratories Inc., Northbrook, IL, USA.
Chen LC, Schlesinger RB (1983) Response of the bronchial|mucociliary clearance system in rabbits to inhaled sulfite |and sulfuric acid aerosols. Toxicol Appl Pharmacol 71:|123-131
Method: other: specific investigation of effect on particle clearance
BASF AG (1980). Department of Toxicology. Prüfung der akuten dermalen Toxizität an der Ratte (77/213), unpublished data, 05 May 1980.
DuPont Chem (1973) Department of transportation skin|corrosion test on rabbit skin with p-nitrotoluene,|technical. November 11, 1973: NTIS/OTS 0572884
Monsanto report AB-84-X128 as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Brooks AL, Seiler FA, Hanson RL, Henderson RF. (1989) In|vitro genotoxicity of dyes present in colored smoke|munitions. Environ Mol Mutagen 13, 304-313
Hansch, Leo, and Hoekman (1995). Exploring USAR,|Hydrophobic, Electric, and Steric Constance. ACS|Professional Reference Book, American Chemical Society,|Washington DC.
Mineshita, T., Okino, I., Yui, Y., Furukawa, S. and Wakabayashi, K. (1978) p-Toluic acid no kyusei dokusei shiken, Kiso to Rinsho, 12(8), 79-90. (in Japanese)
Matthews EJ, Spalding JW and Tennant RW (1993).|Transformation of BALB/c-3T3 cells: V. transformation|responses of 168 chemicals compared with mutagenicity in|Salmonella and carcinogenicity in rodent bioassays. Environ.|Health Perspect. Suppl. 101, 347-482.
Hoechst AG (1981) Inhalationstoxizität im Zeitsättigungstest|von p-Nitrochlorbenzol an männlichen und weiblichen|SPF-Wistar Ratten. Unveroeffentl. Unters. Bericht: 81.0389,|8. Juli 1981
Method: other: 6 rats/sex, nose-only-exposition, 7 hours, post exposure observation time: 14 days, pathological examination
Toxicity to microorganisms, IUC4#44/Ch.4.4
Environmental Health Criteria 74 (1987) Diaminotoluene, World Health Organization, Geneva 1987. (Buist, 1970 and CRC, 1975)
Bringmann,G., Kuehn,R., Zeitschrift Wasser Abwasser|Forschung 15(1), 1-6, 1982, No information
Method: other: Static Acute Toxicity Test (Open System)
Short-term toxicity to aquatic invertebrates, IUC4#17/Ch.4.2
Toxicity to terrestrial plants, IUC4#10/Ch.4.6.2
Camilleri, Watts, Boraston (1988): J. Chem. Soc., Perkin|Trans. 2(9), 1699-1707
Method: other (measured): shake-flask method
Gerhold,R.M., Malaney,G.W., JWPCF 38(4), 562-579, 1966, No information
Method: other: Respirometric Test (Warburg)
Carls N, Schiestl RH (1994) Evaluation of the yeast DEL|assay with 10 compounds selected by the international|program on chemical safety for the evaluation of short-term|tests for carcinogens. Mut Res 320: 293-303
Genetic toxicity in vitro, IUC4#59/Ch.5.5
Tsutsumi S, Yamaguchi T, Komatsu S and Tamura S (1969). On|the teratogenic effects of vitamin A-like substances. Proc.|Congenital Anomalies Res. Assoc., Annual Report No. 9, 27.
Roche, data compilation, ecotoxicological evaluation,|beta-ionone, unpublished data, E-29/89, 02 Aug. 1989
Flaningam, O.L. 1979. Dow Corning Corporation Internal|Report No. 1979-I0039-11.
BASF AG (1966) Study on teratogenic effects of choline|chloride in the mouse after i.p. injection. Department of|Toxicology, Report No. XIV/156, 14.10.1966
Dietschy A (1992). FAT 65'023/N: Report on the modified|Zahn-Wellens-Test on inherent biodegradability. CIBA-GEIGY|Ltd., CH-4002 Basel (Switzerland)
OECD Guideline 302 B (Inherent biodegradability: Zahn-Wellens/EMPA Test)
BASF AG (1989). Department of Ecology, Acute toxicity of triphenylphospine for Daphnia magma, Unpublished Report, Study No. 1/1165/2/88, 23 March 1989.
Alexandrov, V.A., Novikov, A.I., Zabezhinsky, M.A.,|Stolyarov, V.I., and Petrov, A.S. (1989) The stimulating|effect of acetic acid, alcohol, and thermal burn injury on|esophagus and forestomach carcinogenesis induced by|n-nitrososarcosin ethyl ester in rats. Cancer Lett.|47:79-185. Cited in BIBRA (1993)
Huels AG (1989). Unpublished study report #1581. Cited in:|ECB IUCLID 2000.
Etzel JE and Grady CPL (1972). Effects of dyes on an|anaerobic system. Chapter VII in: Dyes and the environment,|Vol. I, American Dye Manufacturers Institute Inc.
Biodegradation in water: screening tests, IUC4#20/Ch.3.6
Vernot EH, MacEwen JD, Haun CC, Kinkead ER (1977) Acute|toxicity and skin corrosion data for some organic and|inorganic compounds and aqueous solutions. Toxicol Appl|Pharmacol 42: 417-423
Method: other: according to Smyth et al., Am. Ind. Hyg. Ass.J. 23: 95-107 (1962): no further details given
Anderson, B.G., Sewage Works J. 18, 82-87 (1946)
BASF AG, Department of Toxicology, Bericht über die Prüfung|der akuten dermalen Toxizität von "AEEA-S" an der Rückenhaut|weißer Kaninchen (77/715), unpublished data, 23 Aug 1979.
Sato, H. et al. (1987): Cancer Lett. 38, 49 - 56
Method: other: Initiation/Promotion Assay
Eastman Chemical Company. 2005. Product Data Sheet for "Eastman" DE Acetate on line at www.eastman.com.
Salmonella typhimurium (TA 1535, TA 1537, TA 1538, TA 98, and TA 100)
Freeman, L. & Fowler, I. (1953): Toxicity of combinations of|certain inorganic compounds to Daphnia magna straus. Sewage|Ind. Wastes 25(10), 1191-1195
Short-term toxicity to aquatic invertebrates, IUC4#60/Ch.4.2
Neeper-Bradley T, Ballantyne B, Losco P, Pritts I and Neptun|D (1995). Investigation of the developmental toxicity|potential of 5-ethylidene-2-norbornene vapor in the CD rat.|International J. of Occupational Medicine and Toxicology 4,|371-381.
Method: other: Developmental toxicity (Teratogenicity) study
L5178Y mouse lymphoma cells (strain TK+/- 3.7.2c)
Fujisawa,S., Masuhara,E., J. Biomed. Mat. Res.15, 787-793,|(1981)
Bioaccumulation: aquatic / sediment, IUC4#5/Ch.3.7
Jagannath, D.R. (1978) Mutagenicity evaluation of G-105 in|the Ames Salmonella/microsome plate test. Unpublished|report of The Dow Chemical Company.
Method: other: Ames Salmonella/Microsome Plate Test
FMC, Toxicology department, Princeton, letter of March 8,|1994 (1994).
Guzzie, P.J. 1988. Organofunctional Silane A-1120 In Vivo|Mouse Micronucleus Study. Bushy Run Research Center Project|Report Number 51-55, October 14, 1988.
Method: other: EPA Health Effect Test Guidelines, EPA Report 560/6-83-001
Method: other: according Carpenter CP and Smyth HF Jr (1946) Chemical Burns of the Rabbit Cornea. Am J Ophthal 29:1363, see also freetext TC
Salmonella typhimurium TA 98, TA 100, TA 1535, and TA 15375
Hoechst AG (1980) Internal study: Akute Toxizität von|para-Nitrochlorbenzol an Goldorfen (Leuciscus idus f.|melanotus). Unveroeffentl. Unters. Bericht: 80.0564
Method: other: alkaline elution assay (DNA strand break)
Genetic toxicity in vitro, IUC4#194/Ch.5.5
Biodegradation in water: screening tests.001
Bayer AG (1959). Kimmerle G. Short report dated 1959-04-22.
Bushy Run Research Center (1988) Trimethoxysilane (Silane|Y-11072) Acute Toxicity and Primary Irritancy Studies.|Project Report 51-26. April 6, 1988
BASF AG, Department of Toxicology, Report on the study of|3-methylbuten-2-al-1 (ZST test substance No.: 88/363) in the|liquid suspension assay, modified Salmonella /|mammalian-microsome mutagenicity test (Ames preincubation|test), unpublished report, project no. 41M0363/884496, 23|Sep. 1991
Brooks, A.S., Seegert, G.L. (1977); The effects of|intermittent chlorination on rainbow trout and yellow|perch.; Trans. Amer. Fish. Soc., 106, 278-286.
Short-term toxicity to fish, IUC4#22/Ch.4.1
Hoechst AG, Report No. 491/75: Akute orale Toxizität von|o-Nitrochlorbenzol an männlichen SPF-Wistar-Ratten,|1975/oct/01
Method: other: 10 rats/dose, males were more sensitive in a pre-test, starved 16 hrs prior appl. and 2 hrs post appl., 4 doses, dissolved in sesame oil, single application by gavage, observation time: 14 d
BASF AG, Analytik; unveroeffentlichte Untersuchung (BRU 91.369 vom 26.04.1991)
Method: other (calculation): Estimation using PCKOCWIN (ver. 1.66)
Genetic toxicity in vitro, IUC4#26/Ch.5.5
Dunn, Johnson. (1983) Plank Struct Act Relat 2 156-163
European Chemicals Bureau (2004) IUCLID Dataset,|1,1,1,3,3,3-Hexamethyldisilazane (999-97-3) (2000 CD-ROM|edition). Available from the database query page:|http://ecb.jrc.it/esis/esis.php as of March 15, 2004.|Cited in NISC and BiblioLine (2009) BiblioLine - |www.nisc.com
Saillenfait A.M. et al.:"Relative Developmental|Toxicities of Acrylates in Rats Following Inhalation|Exposure", Toxicological Sciences, 48, 240-254, (1999)
Waggy, Payne. 1974. Union Carb. Corp. DOC I.D. 40-8485035, NTIS/OTS 0521550
Bayer AG 1979a, Internal study: Toxicity to Leuciscus idus|(1979.11.19)
Kozuka et al. (1980): Pigmented contact dermatitis from azo|dyes. Contact Dermatitis 6, 330-336
primary rat- and hamster hepatocytes in vitro
Alkanes, C10-13, chloro (Short Chain Chlorinated Paraffins)
Method: other: alkaline sucrose sedimentation assay (DNA strand breaks)
Genetic toxicity in vitro, IUC4#183/Ch.5.5
Tsuji, S. et al., Eisei Kagaku 32, 46-53 (1986)
Toxicity profile benzoic acid and its common salts (1989).|BIBRA UK.
Swenberg, J.A. et al.: In Formaldehyde - Toxicology,|Epidemiology and Mechanismus, ed Clary, JJ., NY, pp 225 -236|(1983), No information
Repeated dose toxicity: inhalation, IUC4#57/Ch.5.4
Wikström P, Hägglund L, Forsman M (2000) Structure of a|Natural Microbial Community in a Nitroaromatic Contaminated|Groundwater Is Altered during Biodegradation of Extrinsic,|but Not Intrinsic Substrates. Microb Ecol 39: 203 - 210
Lecat (1928). Nouveaux Azeotropes Binaires. Ann. Soc.|Scient. Bruxelles 48 I, 113-126.
Handbook of Environmental Data on Organic Chemicals (1996).|3rd edition, Van Nostrand Reinhold Co.
NTP (1992): Toxicology and carcinogenesis studies of|chlorinated water and chloraminated water in F344/N rats and|B6C3F1 mice, NTP Technical Report 392, NIH publication no.|92-2847.
Method: other: : generally followed OECD 453 Combined Chronic Tox/Carcinogenicity Study.
Method: other: application in tricaprylin (mice killed at 24 wk)
Malysheva MV, Saitzeva EP, Ivanov YuV (1983) Effects after|dermal application with o-toluidine in rats. Gig Tr Prof|Zabol 9: 47-49
Douglas, G.R. et al., Prog. Mutat. Res. 5, 359-366 (1985)
Syracuse Research Corpration, Environmental Science Center|http://esc.syrres.com/interkow/physdemo.htm
O'Neil MJ, et al. (eds.) (2001). The Merck Index - An|Encyclopedia of Chemicals, Drugs, and Biologicals.|Thirteenth Edition. Merck Research Laboratories, Merck &|Co., Inc. Whitehouse Station, NJ, USA.
IITRI. 1988b. Acute inhalation toxicity study of|trimellitic acid in rats. Final Report. IITRI Project No.|L8100, Study No. 1423, Test Article No. 228C.
Allied Biochemical Toxicology Dept. (1979) Short-Term Mutagenicity and Cell Transformation Screening of Toluene Diamine, III. Enhancement of Viral Transformation of Primary Hamster Embryo Cells by Four Toluene Diamine Isomers. EPA Document No. 40-8236059, Fiche No. OTS0506457. (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com)
Harris, C.C. et al.: In Vitro Toxicol. 2, 183-196 (1988), No information
Genetic toxicity in vitro, IUC4#213/Ch.5.5
Lewis RJ (1996). Sax's dangerous properties of industrial|materials. 9th edition, Van Nostrand Reinhold, p. 2952.
Umemura T, Katahira K, Tamura K, Katsumata T (1999).|Preliminary reproduction toxicity sreening test of|dicyclohexylamine by oral administration in rats. Ministry|of Health and Welfare (MHW, Japan) Toxicity Testing Reports|of Environmental Chemicals Vol.7, 355-365, 717-725.
Method: other: OECD TG 421: preliminary reproduction screening test
APCI, Dabco Triethylenediamine Skin Sensitization Study,|unpublished study, APCI RRRS EXT-92/018, 16 Dec 1991
Short-term toxicity to aquatic invertebrates, IUC4#8/Ch.4.2
Vasilenko et al; (1974): Gig. Sanit. (8), 103-104
BASF (2002) Calculation of soil sorption coefficient with|PCKOCWIN v 1.66. BASF AG, Product Safety, Regulations,|Toxicology and Ecology 24.07.2002 (unpublished data)
Method: other (calculation): PCKOWIN, v1.6
Adsorption / desorption, IUC4#11/Ch.3.3.2
Duraiswami, P. K.: Bull. John Hopkins Hosp. 95, 57-67 (1954)
CIIT (1977). CIIT Docket 22397. A thirty day toxicology|study in Fischer 344 rats given dinitrotoluene, technical|grade, Chemical Industry Institute of Toxicology, Research|Triangle Park, USA
Repeated dose toxicity: inhalation, IUC4#150/Ch.5.4
Farkas, A., Mills, G., Erner, W., and Maerker, J.,|Triethylenediamine Physical, Chemical, and Catalytic|Properties, J. Chem. Eng. Data, 4, 334, 1959
ECT (2007). Sodium formate, BCFWIN v.2.17 calculations. ECT Oekotoxikologie GmbH, Flörsheim/Main, Germany, 01 Aug 2007, (unpublished).
Method: other: calculated Bcfwin (v2.17)
Huntingdon Research Centre Ltd. (1987) Acute oral toxicity|to rats of Isobutyltriethoxysilane. Report 87414D/DNN 11/AC.|Degussa-Huls AG-NR.: 87-0269-FGT May 13, 1987
KM Lab (1998). Biodegradation of sodium formate in seawater|- Closed Bottle Test. Final report No. R 127-98, prepared|for Perstorp AB, 03 Dec 1998, unpublished.
OECD Guideline 306 (Biodegradability in Seawater)
Biodegradation in water and sediment: simulation tests, IUC4#0/Ch.3.5
Kilbey BJ and Zetterberg LG. Mutagenicity assays on|fluorescent whitening agents using microorganisms. in:|Anliker R and Müller G, guest eds., Fluorescent whitening|agents. EQS Environmental Quality and Safety, Suppl. Vol.|IV, 264-277, Georg Thieme Verlag, Stuttgart, 1975.
FMC Corporation, Ammonium persulfate: acute dermal toxicity|study in rats, Study no. I91-1200, 1991.
Bayer AG (1975). Thyssen J. Untersuchung zur Haut- und|Schleimhautvertraeglichkeit. Short report dated 1975-02-20.
NIOSH (1985) Registry of Toxic Effects of Chemical|Substances (RTECS), 1983-84 Supplement, Vol. 2: 1818
Bacillus subtilis H17 (rec+), H45 (rec-)
Curtis, M.W. and Ward, C.H., Journal of Hydrology 51,|359-367 (1981)
Short-term toxicity to aquatic invertebrates, IUC4#24/Ch.4.2
Angerhofer RA, Michie MW, Leach GJ, Aberdeen Proving Ground,|MD: U.S. Army Center for Health Promotion and Preventive|Medicine, Subchronic oral toxicity of thiodiglycol in rats,|Report No. 6415-38-97-05-01, 4. Dec. 1997 (1997)
Method: other: Toxicology Programs SOP 17.97, Approximate lethal dose procedures, USACHPPM, 1997
Ciba-Geigy Ltd., Report on the test for the chemical oxygen|demand of Irganox 1076, Project No 92 8139; 09.06. 1992.
EU Method C.6 (Degradation: Chemical Oxygen Demand)
Thyssen J (1979a) Bayer AG data, Untersuchung zur Haut- und|Schleimhautverträglichkeit, march/19/1979
Shamilov T.A. et al (1973), Tr. Azerb. Nauchno-Issled Inst.|Gig. Tr. Prof. Zabol., 8, 12-15.
Repeated dose toxicity: inhalation, IUC4#25/Ch.5.4
Hazleton Laboratories America, Inc. (1983) Acute Oral|Toxicity Study in Rats. Methyl Mercaptoprionate. Project|No. 652-152.
Method: other: similar to OECD 401 and OPPTS 870.110
Chemicals Evaluation and Research Institute (CERI). (2001).|Report of Hydrolysis rate of MMB, Report Number 81949.|Unpublished Report.
Vohr HW (1993). Isophorondiisocyanat - Untersuchungen auf hautsensibilisierende Wirkung bei Meerschweinchen (Maximierungstest nach Magnusson und Kligman). Bayer AG (Wuppertal) Report No. 22645 (unpublished).
Method: other: OECD Guideline 406 (1992) and Directive 84/449/EEC, B.6
Herbold B (2006). Isophorone diisocyanate - micronucleus test on the male mouse after inhalative exposure for 6 hours. Bayer HealthCare Report No. AT03075 (unpublished).
Kramer JB (1992). Fluorescent whitening agents. In:|Hutzinger O (ed.). The Handbook of Environmental Chemistry|3F. Springer Publishers, Berlin-Heidelberg, 351-366.
Hansch, C., Leo, A., D. Hoekman.: Exploring QSAR -|Hydrophobic, Electronic, and Steric Constants, vol. 2,|Washington, DC, American Chemical Society., 4 (1995)
Bayer Chemicals (Lanxess) (2004). Material Safety Data Sheet|of C.I. Fluorescent Brightener 28/113, MSDS-No. 122738.
Ullman's Encyclopedia of Industrial Chemistry (1999). 6th|Edition.
Merck (1990) ZUS/Analytik, Bericht Nr. 04/03/90 (1990)
MHW Japan (1999), Ministry of Health and Welfare, Toxicity Testing Reports of Environmental Chemicals 6, 297 - 322, 1999.
Guzzie, P.S., Slesinski, R.S. and Frank, F.R. (1987)|N-aminoethylpiperazine Salmonella/microsome (Ames) bacterial|mutagenicity assay. Unpublished report of Union Carbide|Corporation.
Bartsch W, Sponer G, Dietmann K, Fuchs G (1976) Acute|toxicity of various solvents in the mouse and rat. LD50 of|ethanol, diethylacetamide, dimethylformamide,|dimethylsulfoxide, glycerine, N-methylpyrrolidone,|polyethylene glycol 400, 1,2-propanediol, and Tween 20|(German), Arzneimittelforschung 26, 1581-1583
Method: other: based on OECD Guide-line 401
BASF AG, dept. of toxicology, unpublished data,|(26M0231/934206), 12-15-1995
Zhao Y, Wang L, Gao H, Zhang Z (1993) Quantitative Structure|- Activity Relationships - Relationship between Toxicity of|Organic Chemicals to Fish and to Photobacterium phosphoreum.|Chemosphere 26 (11): 1971 - 1979
Toxicity to microorganisms, IUC4#205/Ch.4.4
National Institute of Environmental Research (NIER), 2003. Acute oral toxicity of Calcium sulfate dihydrate (Report No. G02082), Tested by KRICT, Korea
OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
Anon. (undated). National Technical Information Service,|OTS0533574, as cited in RTECS 1998
Rushbrook, C. J.: (Task Directive 13) Final Report (draft)|prepared for Health Research Division, Office of|Toxic-Substances, EPA, Contract No. 68-01-5079. SRI|International, Menlo Park, CA (October 1982).
Torkelson, T.R., and Rowe, V.K.: Patty's Industrial Hygiene|and Toxicology, Third Revised Edition, Vol 2B, Toxicology,|Chapter 48, pp. 3436-3442. Edited by G.D. Clayton & F.E.|Clayton (1981).
Alexander, Lustigman (1966) J. Agr. Food Chem. 14:410-413.
Biodegradation in water: screening tests, IUC4#14/Ch.3.5
Escherichia coli PQ37 (sulA::lacZ, Pho(c))
Method: other: Estimation of the maximum tolerated dose to select doses for cancerogenesis bioassay (see also freetext TC)
Wallen, I.E., Greer, W.C. and Lasater, R. (1957) Toxicity to|Gambusia affinis of certain pure chemicals in turbid waters.|Sewage Ind. Wastes, 29(6), 695-711.
Zhang J-Z, Millero FJ (1991): The rate of sulfite oxidation|in seawater. Geochimica et Cosmochimica Acta 55, 677-685
Hansch, C. Leo, A. 1979. Substituent constants for|correlation in chemistry and biology. New York, Chichester,|Brisbane, Toronto, John Wiley & Sons, p.173.
Sziza M and Magos L (1959) Toxikologische Untersuchung|einiger in der ungarischen Industrie zur Anwendung|gelangenden aromatischen Nitroverbindungen. Arch Gewerbepath|Gewerbehyg 17: 217-226
Method: other: according to Draize et al., J. Pharm.(Lond.) 82, 377 (1944), observation period: at least 96 h
Carter, D. V. et al.: J. Pharmacol., Suppl. 10, T149-T159|(1958)
APCI, Dabco Catalyst; Acute Oral Toxicity Of (Repeat Study),|unpublished study, APCI RRRS EXT-80/024, 29 Aug 1980
Stankowski Jr., L.F. et al.: Environ. Mutagen. 8, 81|(1986),abstract no. 217, No information
Genetic toxicity in vitro, IUC4#91/Ch.5.5
Niederer C, Behra R, Harder A, Schwarzenbach RP, Escher BI (2003). Mechanistic approaches for evaluating the toxicity of reactive organochlorines and epoxides in green algae. Environ. Tox. Chem. 23, 697-704.
Method: other: growth recovery test, fluorescence assay and glutathione assay
Toxicity to aquatic algae and cyanobacteria, IUC4#15/Ch.4.3
Frosch, P.J., Kligman, A.M. (1976). The|chamber-scarification test for irritancy. Contact Dermatitis|2:314-324.
Method: other: Chamber scarification test
Vernot, E.H. et al.: Toxicology and Applied Pharmaco-|logy 42, 417-423 (1977)
Method: other: according to Smyth, Am. Ind. Hyg. Ass. J. 30, 470 (1962)
Working PK, Butterworth BE (1984) An assay to detect|chemically induced DNA repair in rat spermatocytes. Environ|Mutagen 6: 273-286
Method: other: Preparing a cell suspension composed of post-s-phaser primary spermatocytes and spermatids, incubation with test substance for 18 hrs
BASF AG, Labor Oekologie; unveroeffentlichte Unter-suchung, (Original registration No. 1901210, Date: 02.11.1990)
OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
Biodegradation in water: screening tests, IUC4#30/Ch.3.5
Pratt, J. R., Bowers, N. J., Niederlehner, B. R., Cairns, J.|Jr. (1988): Environmental Toxicology and Chemistry, vol. 7,|679-687.
Short-term toxicity to fish, IUC4#71/Ch.4.1
Carpenter C.P. et al (1946), Amer. J. of Ophtalmology, 29,|1363.
BASF AG (1989). Department of Toxicology, Acute toxicity Golden Orfe, Unpublished Report, Study No. 10F0654/885044, 26 May 1989.
Method: other: DIN 38412 part 15 (1982), similar to OECD TG 203 "Fish, Acute Toxicity Test"
Ciba-Geigy Ltd., Dominant Lethal study on TK 10044, mouse,|No. of experiment 327540, 11.9.1975.
Bayer Industry Services (2005b). 1,4-Dichloro-2-butene (CAS 764-41-0), cis-1,4-dichlorobut-2-ene (CAS 1476-11-5), and trans-1,4-dichlorobut-2-ene (CAS 110-57-6). Calculation of |- log Octanol-Water Partition Coefficient with KOWWIN v1.67, 2000|- Henry's Law Constant with HENRYWIN v.3.10, 2000|- Henry's Law Constant with HLC-formula (vapour pressure/water solubility)|- Indirect Photodegradation with AOPWIN v1.19, 2000|- Soil Adsorption Coefficient with PCKOCWIN v1.66, 2000|- Bioconcentration Factor with BCFWIN v2.15, 2000|- Mackay-Distribution Level I according to Mackay D., 1991.
Method: other (calculated): with AOPWIN v1.91, 2000
Salmonella typhimurium TA92, TA135, TA100, TA1537
Biodegradation in water: screening tests, IUC4#47/Ch.3.5
Flavor and Extract Manufacturers' Association of the United|States, DC (1979), Scientific literature review of alicyclic|compounds of carbon, hydrogen and oxygen in flavor use - 4th|supplement, prepared for US Food and Drug Administration,|PB-298385, April 1979
BASF AG, Department of Toxicology, unpublished study Report on the study of the subacute toxicity of n-butyl acrylate in the 13-week inhalation study on Sprague-Dawley rats, (XXVI/352), May 30, 1978
Waller, D.L., Rasch, J.J., Cope, W.G., Marking, L.L. (1993).|Toxicity of candidate molluscicides to zebra mussels|(Dreissena polymorpha) and selected nontarget organisms. J.|Great Lakes Res. 19(4):695-702.
Ishida, R. et al.: Cell Struct. Function 10, 405-409 (1985);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
George J and Kuttan R (1996) Lack of induction of chromosome|aberrations and micronuclei by|N-(1,3-dimethylbutyl)-N-phenylparaphenylenediamine in mouse|bone marrow cells. Mutat Res 370: 191-194
Takasago International Corporation (1999). Beta-Ionone|(CAS-no.: 14901-07-6). Toxicology studies in the Guinea pig.|Final report. Acute dermal irritation / photoxicity study,|skin sensitisation: Magnusson and Kligman Maximisation,|unpublished report (test no. P-4908), English description,|August 4, 1999
Method: other: Morikawa F et al. (1974). Techniques for evaluation of phototoxicity and photoallergy in laboratory animals and man, Sunlight and Man, University of Tokyo Press, Japan, 529-557
CHEMICALS INSPECTION & TESTING INST.-JAPAN. Biodegradation|and Bioaccumulation DATA of EXISTING CHEMICALS BASED on the|CSCL JAPAN. Published by Japan Chemical Industry|Ecology-Toxicology & Information Center, October 1992.
Bayer Chemicals (2004). Internal report: Thermoanalysis of|C.I. Fluorescent Brightener 28/113 (K/Na-salt).
Method: other: DSC821 Standard (Differential Scanning Calorimetry)
Short-term toxicity to fish, IUC4#16/Ch.4.1
Watrous RM and Schulz HN (1950) Cyclohexylamine,|p-Chlornitrobenzene, 2-Aminopyridine: Toxic effects in|industrial use. Ind Med Surg 19: 315-320
PTB-Laboratorium 3.31 (2003). Empfohlene|Sicherheitstechnische Kenngrössen. Data base PTB Lab. 3.31.|Cited in: CHEMSAFE (C) DECHEMA e.V. (update 03 Aug 2004).
Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA1538, Escherichia coli WP2 uvrA
Matsui S, Murakami T, Sasaki T, Hirose Y, and Iguma Y|(1975). Activated sludge degradability of organic substances|in the wastewater of the Kashima petroleum and|petrochemical industrial complex in Japan. Prog. Water Sci.|Technol. 7, 645-659.
Bayer AG (2002a) Report on 4-Aminodiphenylamine.|Investigation on stability in aqueous test solutions.|Unpublished study (2002-09-30)
Method: other: test design comparable to OECD Guideline 111
Curtis MW et al. (1978) Proc. Natl. Conf. Contr. Haz. Mater. Spills, 99-103.
Method: other: Methods for Acute Toxicity Tests with Fish, Macroinvertebrates, and Amphibians, EPA-660/3-75-009, 1975
Method: other: according to Koenemann (1981)
Hansch C, Leo A and Hoekman D (1995). Exploring QSAR,|Hydrophobic, Electronic and Steric Constants. ACS|Professional Reference Book, American Chemical Society,|Washington, DC.
Combined chronic toxicity/oncogenicity study with HCFC-124. |Two-year inhalation study in rats. E.I du Pont de Nemours|and Company, Haskell Laboratory for Toxicology and|Industrial Medicines, Delaware, HLR No., 60-95, August 1995.||Malley, L.A., Frame, S.R., Elliott, G.S., Bentley, K.S.,|Brock, W.J., Trochimowicz, H.J. and Rusch, G.M. Chronic|toxicity, oncogenicity, and mutagenicity studies with|chlorotetrafluoroethane (HCFC-124). Drug and Chem Toxicol,|Vol 21 (4), 417-447, 1998.
Kramers, P.G.N., Voogd, C.E., Knaap, A.G.A.C., Van der|Heijden, C.A., 1985a. Mutagenicity of methyl bromide in a|series of short-term tests. Mutat. Res., 155: 41-47.
ISO 8192 (Test for Inhibition of Oxygen Consumption by Activated Sludge)
Salmonella typhimurium strains TA1535, TA100, TA1537, TA1538, TA98
Smyth Jr. HF, Carpenter CP, Weil CS (1951). Range-finding toxicity data: List IV. Arch. Ind. Hyg. Occup. Med. 4, 119-122.
Method: other: 0.005 ml of the undiluted material was applied to the centre of the cornea. After 18 to 24 h the injury was scored.
Hazelton UK (1988) Neodecanoyl chloride: Acute inhalation|toxicity study - LC50 rats (4 hour exposure). Hazleton UK|Report No. 5743-532/4 for Societe Nationale des Poudres et|Explosifs, Toulouse, France, dated Sept. 1988.
Mochizuki, M. (1995). A toxicity study of sodium gluconate|(FR2531) by single oral administration in rats. Final|report No. BOZO/B-2965 from Gotemba Laboratory, Bozo|Research Center, Inc., Setagaya-Ku, Tokyo 156, Japan.
BASF AG, Department of Toxicology; unpublished study|(XXII/230), 23.01.73
Bodes E, Nakamura J, Swenberg JA (2003) SOT Annual Meeting|Abstract No. 994.
Method: other: indirect assay for poly(ADP-ribose) polymerase (PARP) activation (formation of intracellular NAD(P)H)
Genetic toxicity in vitro, IUC4#43/Ch.5.5
Salmonella typhimurium TA 98, TA100, TA1535, TA1537, TA102, TA104 Escherichia coli WP2urA, WP2urA/pKM101
Degussa (1999). Material safety data sheet according to|93/112/EC, update 18 Jan 1999.
Litton Bionetics, Rundell JO (1982) Evaluation of 8048-69-5|WTR No. 2 6PPD in the in vitro transformation of BALB/3T3|cells assay, final report. Litton Bionetics Inc. Project|No.: 20992, unpublished study of Goodyear Tire & Rubber Co
Verhaar H. J. M., Mulder W., and Hermens J.L.M.; (1995)|QSARs for ecotoxicity. In: overview of structure-activity|relationships for environment endpoints, Part 1: General|outline and procedure; Hermens J.L.M (ed.), Report prepared|within the framework of the project "QSAR for Prediction of|Fate and Effects of Chemicals in the Environment", an|international project of the Environmental Technolog|Programme (DGXII/D-1) of the European Commission under|contract number EV5V-CT92-0211.
Thain, J.E., M.J. Waldock, and M.E. Waite. 1987. Toxicity and Degradation Studies of Tributyltin (TBT) and Dibutyltin (DBT) in the Aquatic Environment. In: Proc. Intern. Organotin Symp. Oceans 87 Conf. Halifax, N.S. Sept. 29-Oct. 1. 4:1398-1404.
Long-term toxicity to aquatic invertebrates, IUC4#6/Ch.4.5.2
de Roode, D.F. and H.P.M. de Haan. 2004. 8-Oxa-3,5-dithia-4-stannatetradecanoic acid, 10-ethyl-4-[[2-(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-methyl-7-oxo-, 2-ethylhexyl ester [Methyltin tris(2-ethylhexylmercaptoacetate), CAS No. 57583-34-3]: Daphnia magna, reproduction test (semi-static). NOTOX Project 375031. December 3, 2004.
Short-term toxicity to fish, IUC4#51/Ch.4.1
Purchase I.H.F. Studies in Kaffir Corn Malting and Brewing.|XXII. The Acute Toxicity of Some Fusel Oils Found in Bantu|Beer. So. Afr. Med. Jor. 43(25):795-798. 1969.
Method: other: single dose, stomach tube
Knacker et al., 1993. A Study of the Toxcity to Algae|(Scenedesmus subspicatus) of Trimellitic Anhydride. Study|Number: BE-EA-128-91-02-ALG-1.
Hill Top-Toxicology. 1978. Extended Acute Oral LD50 Studies of Nine Samples. Ref: 77-1094-21. 25.5.1978.
Barratt MD (1995): Quantitative structure activity|relationships for skin corrosivity of organic acids, bases|and phenols. Toxicol Letters 75, 169-176
Indspec Chemical Corporation (1998) The Resorcinol Handbook.
Fischer et al. (1976) Phytochemistry 15:1078-1079.
Method: other: Growth inhibition test (test parameter: colony formation)
Boettcher J, Popovic J (1992) TINOPAL DMS-E: Report on the|acute toxicity (96h) to zebrafish. CIBA-GEIGY Ltd., CH-4002|Basel (Switzerland)
Izmerov NF, Sanotsky IV, Sidorov KK (1982) Toxicometric|parameters of industrial toxic chemicals under single|exposure. Centre of International Projects, GKNT, Moscow, p.|24
Sasaki, K. et al., Bull. Environ. Contam. Toxicol. 27,|775-782 (1981)
OECD Guideline 305 D (Bioaccumulation: Static Fish Test)
Koopman, T.S.M. and Pot, T.E. (1986) Primary irritation|study of calcium chloride 33% to the eye of the male rabbit.|Duphar Report No. 56645/45/86.
Bayer AG (2003). Properview Database, data sheet for|dinitrotoluene (CAS 25321-14-6).
Butjagin PW (1904). Experimentelle Studien ueber den Einfluß|technisch und hygienisch wichtiger Gase und Daempfe auf den|Organismus. Teil XII: Studien ueber Phosphortrichlorid.|Arch. Hygiene 49, 307-335.
Barbera, J.J. (2005): Sulfites, Thiosulfates, and|Dithionites. In: Ullmann´s Encyclopedia of Industrial|Chemistry. Wiley-VCH Verlag GmbH & Co KGaA.
Ebisuno, T. and Takimoto, M.: Examination on the|Biodegradability of Guanyl Compounds, EISEI KAGAKU, 27(3),|156-162(1981)
Matsubara,H.et al. (1975): Nippon Nogei Kagaku Kaishi 49, 505-511
Kaczur JJ. & Cawlfield DW. (1993). Kirh-Othmer Encyclopedia of Chemical Technology, 4th Ed., 5: 968-997
Howard, P.H., 1989. Handbook of Environmental Fate and|Exposure Data for Organic Chemicals, Volume I: Large|Production and Priority Pollutants. Pp 386-393, Lewis|Publishers, Chelsea, Michigan.
Stauber JL, Florence TM (1987) Mechanism of toxicity of ionic copper and copper complexes to algae. Marine Biology 94:511-519.
Method: other: Determination of Cell Division Rate; investigation not performed to guideline "Cellmultiplication-inhibition Test"
Toxicity to aquatic algae and cyanobacteria, IUC4#42/Ch.4.3
Salmonella typhimurium TA98, TA100, TA1537
Beekhuijzen MEW (2002): One-generation reproduction toxicity|study with Isophytol administered by oral gavage in Wistar|rats. NOTOX Project 340987, unpublished; study performed on|behalf of F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Method: other (calculated): KOWWIN v1.66
Tarras, A. E. et al.: Mutagenicity assay with Salmonella|typhimurium Revealing Biotransformation of Antiphytoviral|Substances by Cell-Plant Extract, Zentralbl. Mikrobiol.,|144, 197-202(1989)
Bayer MaterialScience AG (2006). Bayer isophorone diisocyanate exposure questionnaire (unpublished).
Type of cell used: Chinese hamster lung(CHL) cell
EPA (2008). MPBPWIN v1.42. Estimation Programs Interface for Microsoft Windows (EPI Suite version 3.20, U.S. Environmental Protection Agency, Office of Pollution Prevention and Toxics, Washington, D.C.).
Method: other: The melting point was estimated with EPI Suite version 3.20. The weighted value was used.
Hackett, P.L., M.G. Brown, R.L. Buschbom, M.L. Clark, R.A.|Miller, R.L. Music, S.E. Rowe, R.E. Schirmer, and M.R.|Sikov. 1982. Teratogenic Study of Ethylene and Propylene|Oxide and n-Butyl Acetate. Prepared by the U.S. Department|of Health and Human Services. Public Health Service. Center|for Disease Control. National Institute for Occupational|Safety and Health. Division of Biomedical and Behavioral|Science. Experimental Toxicology Branch, Cincinnati, Ohio|45266. NTIS PB83-258038.
Ministry of International Trade and Industry (MITI)|(1992):Biodegradation and bioaccumulation data of|existingchemicals based on the Chemical Substance Control|Law(CSCL), Japan. Chemicals Inspection and Testing|Institute(CITI) (ed.); Japan Chemical Industry Ecology -|Toxicologyand Information Center 1-27; 4-355
Japanese Ministry of Labour, 1992. Toxicology and|carcinogenesis studies of methyl bromide in F344 rat and BDF|mice (inhalation studies). Tokyo, Industrial Safety and|Health Association, Japanese Bioassay Laboratory, 197 pp|(Unpublished report).
Budavari S (2001). The Merck Index. An Encyclopedia of|Chemicals, Drugs and Biologicals. 13th Edition, p. 1372
Schroeder H A and Mitchener M (1975). Life-term studies in|rats: Effects of aluminium, barium, beryllium and tungsten.|J Nutr 105, 421-427.
Cosma, G.N. and Marchok, A.C.: Toxicology 51, 309-320 (1988), No information
Genetic toxicity in vitro, IUC4#412/Ch.5.5
Graves, R.J. et al.: Carcinogenesis 15, 991-996 (1994), No information
Genetic toxicity in vitro, IUC4#446/Ch.5.5
DuPont- Haskell Laboratory - internal DMAC review, Oct. 1988
Repeated dose toxicity: inhalation, IUC4#19/Ch.5.4
potassium hydroxyoctaoxodizincatedichromate(1-)
BASF AG (2005). Sodium formate - Prenatal developmental|toxicity study in Wistar rats. Unpublished study report No-|30R0123/03036, dated March 23, 2005.
Industrial Health Foundation, Final Report Study No.:|95-6095, March 27, 1997 (Huntington Life Science)
Method: other: according to guidelines described by TSCA, EPA September 1985 and May 1989
Calculation UWS-Produktsicherheit, Bayer AG 1991
Genetic toxicity in vitro, IUC4#53/Ch.5.5
Laboratory of Industrial Medicine, Eastman Kodak Co., 1956
Tokyo Metropolitan Research Laboratory of Public Health|(undated): Chronic toxicity, teratogenicity and|mutagenicity tests with Dibutyl hydroxy toluene; Cytogenetic|studies and dominant lethal test in mice and rats after|long-term administration of dibutylhydroxytoluene (BHT) (no|further bibliographic data)
Genetic toxicity in vitro, IUC4#106/Ch.5.5
Fox M, Delow GF (1985) Tests for mutagenic activity at the|HGPRT locus in Chinese hamster V79 cells in culture. Prog|Mut Res 5: 517-523
Method: other: as described by McMillan and Fox (1979)
Bower EA and Kaji H (1986): Characterization of Human IMR-90|Fibroblasts as a Model System for the Study of Chemical|Carcinogenesis in vitro. J Toxicol Environ Health 19,|165-172
Lisicki Z and Jamroz ME (2000). (Solid + liquid)|equilibria in (polynuclear aromatic + tertiary amide)|systems. J. Chem. Thermodynamics 32, 1335 - 1353.
Method: other: calorimetric measurements
Melting point/freezing point, IUC4#11/Ch.2.1
Method: other: calculated Bcfwin (v2.15)
Genetic toxicity in vitro, IUC4#34/Ch.5.5
General|Electric, physical properties database.
Zinkernagel R (1973). FWA:s and the Water System. NFR|Swedish Natural Science Research Council, Stockholm, |141-148.
Short-term toxicity to aquatic invertebrates, IUC4#9/Ch.4.2
Cesarone CF, Bolognesi C, Santi L (1980) Funzione della|struttura e delle proprieta' chimico-fisiche degli agenti|chimici nell'induzione di alterazioni sul dna:|nitrochlorobenzeni. Boll Soc It Biol Sper 56: 1680-1686
Method: other: other: 4 hrs post appl. mice (number not mentioned) were sacrificed, DNA damage was evaluated by the alkaline elution technique coupled with a microfluorometric method for DNA assay
Method: other: according to Draize et al., J. Pharm.(Lond.) 82, 377 (1944), observation up to 96 hours, no further details of the study available4
Devillers J et al. 2002. Ecotoxicity of ethylene glycol monobutyl ether and its acetate. Toxicol Mech Methods 12:255-263.
Method: E07-04:ISO Guideline 6341 (ISO 1996)
Bushy Run Research Center (1994) Trimethoxysilane: Nine-Day|Vapor Inhalation Study on Rats. Laboratory Project ID|91U0021. September 14, 1994
Cieszlak FS et al. (1996) Propylene glycol monomethyl ether: A 13-week vapor inhalation study to evaluate hepatic and renal cellular proliferation, P450 enzyme induction in B6C3F1 mice. Unpublished report of The Dow Chemical |Company.
BASF AG: Zeller H, Oettel H (1965). Dicyclohexylamin rein,|Gewerbetoxikologische Vorpruefung. Short report XV/273,|7.12.1965.
Method: other: application to the ear, dose: no data, exposure time: 20 hrs, reading: 24 hours and day 8 post exposure
BIBRA (1992) A seven-day toxicity study with thioglycolic|acid 2-ethylhexylester (Thioglykolsäure-2-ethylhexylester,|CAS-No. 7659-86-1, BG-No. 83) Unpublished report no.|932/3/92.
Zewdie T, Furman G, Roberts A, Schatz R (1990) Structure|activity realtionship of toluene, p-xylene, p-nitrotoluene|(PNT) and p-chlorotoluene (PCT) on rat lung and liver|microsomal function and composition. The Toxicologist 10:|120
BASF AG, Physikalische Chemie, unpublished study, BRU|93.264, 05.05.1993
Method: other: dynamic (argon atmosphere); test procedure according to an internal BASF standard, comparable to OECD 104
Bringmann G. (1975), Gesungheits-Ingenieur, 96(9), 238-41.
Hoechst AG, Internal studies: |1. Zahn-Wellens-Test (1982), 2. Respirometer Test (1982), 3.|Toxicity on Bacteria, Anaerobic (1982); no records available
Bayer Health Care AG (2008) 3-Mercaptopropionic Acid Acute|Inhalation Toxicity in Rats (Exposure 1 x 4 hours followed|by a postexposure period of 2 weeks). Report Number AT04704.
Manulkin. 1944. Zh. Obshch. Khim. 14:1049.
CIVS, Chemikalieninformationssystem zu verbraucher-|relevanten Stoffen, (2003). DIMDI Bundesinstitut für|Risikobewertung (BfR), Berlin, Revision date 29.12.2000,|Printing date 30.04.2003
Hawley, G. (Ed.), The Condensed Chemical Dictionary, Van|Nostrand Reinhold, 1981, 416-417 (106).
Harada, Koiwa. (1977): J. Ferment. Technol. 55, 97-102;|cited in: Chem. Abstr. 87, 2191h (1977)
Biodegradation in water: screening tests, IUC4#33/Ch.3.5
Amacher, D.E. and Zelljadt, I.: Mutat. Res. 136, 137-145|(1984);|cited in: IARC Monographs on the Evaluation of Ccarcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
MOE Japan (1999). Ministry of Environment, Chronic toxicity|study of choline chloride on the freshwater invertebrate|Daphnia magna, unpublished study, No. 1998-15
Hazelton Laboratories America, Inc. 1976. Acute Inhalation Toxicity Study in Rats. 80% Mono- 20% Di-Methyltin Chloride. Final Report. 9.2.1976.
Jaeger FM (1917). Über die Temperaturabhängigkeit der|molekularen freien Oberflächenenergie von Flüssigkeiten im|Temperaturbereich von -80 bis +1650 °C. Zeitschrift fuer|Anorganische und Allgemeine Chemie 101, 1-214.
Sukhanov, V.V., Petul'ko, S.N., Bolonova, L.N. and Yulish,|N.R. (1990) Toxicological assessment of calcium chloride and|calcium chloride-containing products. Gigiena Truda I|Professional'nye Zabolevaniya (Labor Hygiene and|Occupational Diseases), 34(5), 51-52.
Chrisman, B.B. (1978), Menthol and Dermatitis, Arch.|Dermatol. 114, 286
Florence TM, Stauber JL (1986) Toxicity of Copper Complexes to the Marine Diatom Nitzschia closterium. Aquatic Toxicology, 8(1): 11-26 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Gostinskii V (1965). Toxicity of isoprene and maximal safe|concentration of the vapour in the air, Fed. Proc. (Transl.|Suppl.), Vol. 24, pp. 1123-1126.
KBwS (1985). Data Sheet No. 210 for evaluation of hazardous|aquatic substances. Kommission Bewertung wassergefährdender|Stoffe, Germany.
Biodegradation in water and sediment: simulation tests, IUC4#19/Ch.3.5
BASF AG, Department of Toxicology, unpublished results,|Proj. No. 36I0587/89045, 19 May 1995
Method: other: based on OECD guide-line 412
Mosinger, M. 1975. Centre D'Exploitations et de Recherches Medicales, Marseille. Final Report Advastab TM 181 FS (Cincinnati-Milacron).
DuPont Haskell Laboratory (1997). H-22361: Two-week|inhalation toxicity study in male rats. Report No.|HL-1997-00236 (unpublished).
Newton, P.E. 1994b. A four-week inhalation toxicity study|of methyl bromide in the dog. Unpublished report from|Pharmaco LSR Project number 93-6068.
OECD Draft Guideline: Acute Dermal Photoirritation Dose-Response Test, February 1995
Hoechst AG unpublished data (Report No. W 82-053)(1982)
Toxicity to microorganisms, IUC4#5/Ch.4.4
Degussa AG, Acute toxicity study with Poecilia reticulata|exposed to ammoniumperoxydisulfat, Study no. 88-0016-DGO,|1988.
Brennan RJ, Schiestl RH (1999) The aromatic amine|carcinogens o-toluidine and o-anisidine induce free radicals|and intrachromosomal recombination in S.cerevisiae. Mut Res|430: 37-45
Genetic toxicity in vitro, IUC4#82/Ch.5.5
Gaunt IF, Colley J, Grasso P, Landsdown ABG, Gangolli SD.1968. Short-term toxicity of diethyleneglycol monoethylether in the rat, mouse and pig. Food Cosmet Toxicol 6:689-705.
Wodzinski, R.S. et al. (1977): Toxicity of SO2 and NOx:|Selective Inhibition of Blue-Green Algae by Bisulfite and|Nitrite. J. Air Pollut. Control Assoc. 27(9), 891-893
Toxicity to microorganisms, IUC4#60/Ch.4.4
Method: other: according to Collins, T.F.X. et al.: Regul. Toxic. Pharmac. 1, 355
Developmental toxicity / teratogenicity, IUC4#28/Ch.5.8.2
Hagan EC et al. (1967). Food flavourings and compounds of|related structure: II. Subacute and chronic toxicity. Food|Cosmet. Toxicol., 5, 141-157, cited in Toxicological|Evaluation of Certain Food Additives, Joint FAO/WHO Expert|Committee on Food Additives, Geneva, WHO Food Additives|Series, No. 19, alpha- and beta-ionone, 72-74, 1984
Loeb, Kellys (1963): U.S. Fish. Wildl. Serv., Sp. Sci., |Rep.-Fish. No. Washington, D.C.: 124
Food and Drug Research Laboratories, Inc. (1978) |Report Submitted to General Electric Co. Approximate |Acute Oral Toxicity (LD50) in Rats, Laboratory |No. 5547. September 23, 1977.
Method: other: a modified procedure in "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics, Published by the Association of Food and Drug Officials of the U.S. (1959).
BASF AG, Department of Toxicology, Bericht über die Prüfung|der akuten Toxizität an der Goldorfe (Leuciscus idus L.,|Goldvariante), unpublished study, 10F0363/885029, 20 March|1989
Method: other: according to DIN 38412, part 15
Sora, S., Luisa, M., Carbone, A., Pacciarini, M. and Magni,|G.E. (1986) Disomic and diploid meiotic products induced in|Saccharomyces cerevisiae by the salts of 27 elememts.|Mutagenesis, 1(1), 21-28.
Genetic toxicity in vitro, IUC4#80/Ch.5.5
Method: other (calculation): application of TGD Koc-formula for anilines
Adsorption / desorption, IUC4#7/Ch.3.3.2
Dawson TAJ, Black RJ, Strang WC, Millership JS, Davies I. 1989. Delayed and immediate hypersensitivity to Carbitols. Contact Derm 21:52-53.
Kirk-Othmer Encyclopedia of Chemical Technology. 4th ed.|Volumes 1: New York, NY. John Wiley and Sons, 1991-present.,|p 4 (92) 277
Hoechst AG, Report No. 493/75: Haut- und|Schleimhautverträglichkeit von o-Nitrochlorbenzol an|Kaninchen, 1975/oct./01
Method: other: appl. to intact and abraded skin, flank, test substance diluted in sesame oil, dose: 0.5 ml/animal, observation time: 72 hrs, reading: 24, 48 and 72 hours, evaluated according Fed.Reg.38, No.187, p.27019, 1973, § 1500.41
Hoechst AG (1988): Unveröffentlichte Untersuchung (88.0432)
Chemical Economics Handbook (CEH) Marketing Research Reports|(1999). SRI International, p. 764.1000 H.
Nidiry, E. S. J. (1998), Structure-Fungitoxicity|Relationships of the Monoterpenoids of the Essential Oils of|Peppermint (Mentha piperita) and Scented Geranium|(Pelargonium graveolens), J. Essent. Oil. Res. 10, 628-631
Method: other: Smyth-Carpenter, Am. Ind. Hyg. Anal. (1962) 27, 95 on which OECD TG 403, Annex 5 was based.
Ansell JM and Fowler JA (1988) The acute oral toxicity and|primary ocular and dermal irritation of selected|N-alkyl-2-pyrrolidones, Fd. Chem. Toxicol. 26, 475-479
Taylor and al. (1985). Effects on chlorine dioxide on|neurobehavioral development of rats. In Jolley R.L. et al.|eds. Water chlorination: chemistry, environmental impact and|health effects. Chelsea, MI, Lewis publications, p355-364.
Beilstein Handbook of Organic Chemistry (Online). Last|updated May 1999. Searched data 31.07.2003.
Smith, S.E. et al.: Fd. Chem. Toxic. 25 (2), 125-133 (1987);|cited in: RIFM database, location no. 5043
BASF AG, (1980) Study on the acute inhalation toxicity LC50 of Butyl Acrylate as a vapor in rats 4-hour exposure, Dept. of Toxicology, unpublished study, (78/623), Feb. 1, 1980
Norppa, H. & Jaerventaus, H., Mutat. Res. 224, 333-337|(1989)
Davis HC and Hidu H (1979) Effects of Pesticides on|Embryonic Development of Clams and Oysters and on Survival|and Growth of the Larvae, Fish Bulletin 67, 393-404
Method: other: in accordance with OECD Guideline 476
Teratogenicity study of HCFC-124 in rats. E.I du Pont de|Nemours and Company, Haskell Laboratory for Toxicology and|Industrial Medicines, Delaware, HLR No., 482-90, October|1991.
Method: other: EPA OTS 798.4900 and OECD Guide-line 414
Kirk-Othmer (1996). Encyclopedia of Chemical Technology, 4th|ed., Vol. 18, 755-768. New York, John Wiley and Sons.
Crosby, R.M. et al.: Environ. Mutagen. 9, 26 (1987),|abstract no. 63, No information
Genetic toxicity in vitro, IUC4#89/Ch.5.5
Mobay Chemical Corporation (1984b). Sensory irritation with isophorone diisocyanate (IPDI) in rats. Report No. 540. NTIS/OTS Microfiche 0515439, Doc 86-870001280.
Method: other: The concentration associated with a 50 % decrease in respiration rates was determined (RD50).
Park Y-S and Park S-J (2000). Determination and|Prediction of Octanol/Water Partition Coefficients and|Air/Water Partition Coefficients for Environmental Toxic|Chemicals. J. Korean Ind. Eng. Chem. 11(7), 773-779.
Method: other (measured): slow stirring method
Huff, J., Environ. Health Perspect. 45, 199-200 (1982)
GESTIS - Substance Database (Information system on hazardous substances of the Berufsgenossenschaften), 13.10.2005
Appearance/physical state/colour, IUC4#4/Ch.1.1.1
Ishidate M Jr, Sofuni T, Yoshikawa K, Hayashi M, Nohmi T,|Sawada M, Matsuko A (1984) Primary mutagenicity screening of|food additives currently used in Japan. Food Chem Toxicol|22:623-636
BASF AG 1992. Technisches Merkblatt [Technical data sheet] Butyldiglykolacetat (12/92)
Beilstein Handbook, Registry Number: 1906911, Last Update:|2002-07-19
Cosma, G.N. et al.: Proc. Am. Assoc. Cancer Res., Annu.|Meet., 28, 117 (1987); abstract no. 464; 78th Annual|Meetingof the American Association for Cancer Research,|Georgia, USA, No information
Genetic toxicity in vitro, IUC4#206/Ch.5.5
RTC (Research Toxicology Centre) (2003). IPDI chromosome aberrations in Chinese hamster ovary cells in vitro. Report No. 8148 (unpublished). RTC (Rome).
Method: other: OECD Guideline 473 (1997) and Directive 2000/32/EC, B.10
BASF AG (1970) Results of a preliminary base testing.|Department of Toxicology, unpublished report No. XX/242,|Sept. 24, 1970
Günzel P and Richter KD (1968a). Isophorone: acute oral|toxicity, rats - single administration (LD50). Schering AG,|Berlin / Bergkamen, Report No. T 5.
Sitarek, K., Berlinska, B., and Baranski, B. Assessment of|the Effect of n-Butanol Given to Female Rats in Drinking|Water on Fertility and Prenatal Development of Their|Offspring. Int. J. of Occupational Medicine and|Environmental Health, 7(4):365-370, 1994.
Toxicity to reproduction, IUC4#40/Ch.5.8.1
Moreno OM (1982): Acute toxicity studies. Report to RIFM,|unpublished. RIFM-FEMA Database, location 1689.
Nahum, A. and C. Horváth, J. Chromatography 192, 315-322|(1980)
BASF (1988): Kalium-Disulfit, Wachstumshemmtest in Anlehnung|an Bringmann-Kühn. DUU/OO - A 520. File No. 9/0896/88,|29.07.1988
Bornmann, G. & Loeser, A., Arzneimittel-Forsch. 9, 9 (1959)|zitiert nach: Henschler, D. (Hrsg.), Gesundheitsschaedliche|Arbeitsstoffe. Toxikologisch-arbeitsmedizinische Begruendung|von MAK-Werten: Caprolactam (1975), 1.-17. Lfg., Verlag|Chemie (1991)
MOE, Japan (1996) Ministry of Environment: unpublished report of prolonged toxicity study of N-tert-butyl-2-benzothiazonylsulphenamide to Medaka (Oryzias latipes).
Helms, D.R.: Prog. Fish Cult., 29, 43-47 (1967);|cited in: IPCS Environ. Health Crit. 89, (1989), No information
Short-term toxicity to fish, IUC4#81/Ch.4.1
BASF AG (1952). Department of Toxicology, toxicity studies,|unpublished study, (R 82 = I/312 = II/196), 17 June 1952
Schering AG. 1990. ZK 22.663. Evaluation of the Clastogenic Potential in the Human Lymphocyte Test. Report No. IC 1/90. 08.08.1990.
Method: other: similar to OECD Guideline 473
toxicity threshold - cell multiplication (growth) inhibition test.
Hatoum, N. and Johnson, W. 1991. Primary eye irritation|study of trimellitic anhydride in rabbits. IITRI Study No.|1693, Test Article No. 128H.
Burg AW, Rohovsky MW, Kensler CJ (1977). Current status of|human safety and environmental aspects of fluorescent|whitening agents used in detergents in the United States.|CRC Crit. Rev. Environ. Control 7, 91 - 120.
Applegate, V.C. et al., Special Scientific Report-Fisheries|No. 207, Washington, D.C., March 1957
Spence, J.W., Hanst, P.L., and Gay, B.W. Jr.: J. of the APCA|26:994-996 (1976).
Reported in Du Pont-Haskell Laboratory- Internal DMAC|Review, Oct. 1988 from BASF, Unpublished Data, 4/6/76.
Barrett J and Livesey PJ (1982) Neurobehav Toxicol Teratol|4, 105. Cited in BIBRA (1993)
Bringmann G. et al (1981), GWF-Wasser/Abwasser, 122(7),|308-12.
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Bayer AG (1975). Bomhard E. Akute orale Toxizitaet (LD50) an|weiblichen Ratten. Short report dated 1975-02-25.
SRC (1988) Syracuse Research Corporation Calculated Values (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com)
Serjeant EP, Dempsey B (1979) Ionisation constants of|organic acids in aqueous solution. IUPAC Chemical Data|Series No. 23, Pergamon Press, Oxford, 1st ed., p. 81
Salmonella typhimrium TA98, TA100, TA1535, TA1537
BASF AG, Product Safety, In vivo unscheduled DNA synthesis|(UDS) assay with 3-methyl-2-butenal in rat hepatocytes,|single oral administration, unpublished report project no.|80M0680/004115, 28 Aug. 2001
OECD Guideline 486 (Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo)
in vitro L1578Y mouse lymphoma TK +/- cells
MOE, Japan (2003): Unpublished data, Acute and Chronic|Ecotoxicity Tests of Allyl Alcohol to a Freshwater Alga,|Daphnids and Fish.
Shell Chemical Corporation. Industrial Hygiene Bulletin No|SD 57-80 Allyl Chloride. New York, Shell Chem. Corp., April,|1958
Wells Laboratories, Inc. 1976. Report on Inhalation LC50 in Rats Using 80% Mono/20% Dimethyltin Chloride. Laboratory No. G-1405. 20.1.1976.
Dow Corning Corporation Internal Report Number|1982-I0065-4122-05
USEPA. 2000. PCKOCWIN, Version 1.66. Soil Adsorption Coefficient. EPIWIN (Estimation Program Interface for Windows). Version 3.11. Office of Pollution Prevention Toxics (OPPTS) and Syracuse Research Corporation.
Wiessler, M. et al.: Carcinogenesis 4, 867-871 (1983)
BASF AG (1974), Technisache Entwicklung Verfahrenstechnik, TET - L 540, unpublished report No. 8-505, 19 Jul 1974
Lewis RJ (1993). Hawley´s Condensed Chemical Dictionary|(12th ed.). Van Nostrand Reinhold, New York, p. 1159.
Toxicity to aquatic algae and cyanobacteria.002
CIBA-GEIGY, Ltd. Skin Irritation in the Rabbit after Single Application of TK 11386. Project No.: Siss 2844. 16.05.1973.
Method: other: US Association of Food and Drug Officials (AFDO); Appraisal of the Safety of Chemicals in Food, Drugs and Cosmetics.
Jenner, P. M. et al.: Fd. Cosmet. Toxicol. 2, 327-343 (1964)
Clark, A.M. and Clark, E.G.: Mutat. Res. 6, 227-234 (1968)
Genetic toxicity in vivo, IUC4#40/Ch.5.6
Abe S, Sasaki M|Chromosome aberrations and sister chromatid exchanges in|chinese hamster cells exposed to various chemicals|J. Natl. Cancer Inst. 58, 1635-1641 (1977)
Kitano M. (1978) Biodegradation and bioaccumulation test on|chemical substances. OECD Tokyo meeting reference book|TSU-No 3
Method: other: calculated: BCFWIN v. 2.14
BASF AG (2005). Safety data sheet according to 91/155/EEC,|N-(2-Aminoethyl)ethanolamine, revised 27 Apr 2005.
Price et al. 1974. J. Water Pollut. Control Fed. 46, 63-77
Method: other: BSB-Method according to Standard Methods for the Examination of Water and Wastewater, APHA (1985)
Hurtt, M.E., Morgan, K.T., Working, P.K., 1987.|Histopathology of acute toxic responses in selected tissues|from rats exposed by inhalation to methyl bromide. Fundam.|Appl. Toxicol., 9:352-365.
Schering AG. 1989. Local dermal tolerance test in rabbits after single application. Bericht Nr. IC 29/89. 20.12.1989.
Winer A.M., Atkinson R. (1987), "Lifetimes and fates of|toxic chemicals in California's atmosphere", California Air|Ressources Board, Final report, Contract no. A5-104-32, Aug.
Huntingdon Research Centre Ltd. (1988) The acute toxicity of|Dynasylan IBTEO Kondersat to rainbow troup (Salmo|gairdneri). Report DNN 28(c)/88373. Degussa-Huls AG-Nr.:|88-0333-DGO August 18, 1988
Ishidate M. and Yoshikawa K. Arch. Toxicol. Suppl. 4:41-44|(1980)
Blabaum and Nichols (1958), cited in Environmental Health|Criteria 21, WHO (1982)
Repeated dose toxicity: oral, IUC4#28/Ch.5.4
Galloway SM et al. (1987). Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Mol. Mutagen. 10 (Suppl. 10), 1-175.
BASF AG (1993). Department of Analytical Chemistry, report|BRU 93.211, 20 Jan 1993, unpublished.
Method: other (measured): comparable to OECD 104
Maruyama H, Amanuma T, Nakae D, Tsuitsumi M, Konda S, Tsujiuchi T, Denda A, Konishi Y (1991) Effects of catechol and ts analogy on pancreatic carcinogenesis initiated by N-nitrosobis(2-oxopropyl)amine in Syrian hamsters. Carcinogenesis 12(7):1331-1334.
Boyd, E.M. and Seymour, K.G.W. (1946) Ethylenediamine|dihydrochloride or "chlor-ethamine". Exp. Med. Surg., 4,|223-227.
Safepharm Laboratories (2003) Neodecanoyl chloride:|Determination of Hydrolysis as a function of pH. SPL Project|No 1683/010
Katz, A.J., 1985. Genotoxicity of methyl bromide in somatic|cells of Drosophila larvae. Environ. Mutagen., 7:13|(abstract)
Clastogenic activity in cultured Human lymphocytes
Method: other: Methods for acute toxicity tests with fish, macroinvertebrates, and amphibians. United States Environmental Protection Agency, EPA 660/3 75 009, 1975
Berufsgenossenschaft der chemischen Industrie,|Salmonella/Mammalian-Microsome Mutagenicity Test|(Preincubation Procedure) With Triethylenediamine, APCI RRRS|EXT-03/014, 17 Dec 1986
Price, K.S., G.T. Waggy, and R.A. Conway. 1974. Brine Shrimp|Bioassay and Seawater BOD of Petrochemicals. J. Water|Pollut. Contr. Fed. 46:63-77.
Dill, D.C. (1980) Evaluation of isooctyl thioglycolate|(IOTG) in the aquatic environment. Unpublished Dow report.
BASF (2006) Physico-chemical properties of "ortho-Toluenediamine (o-TDA), Study no. 06L00183.
short-term test program sponsored by the division of Cancer|Etiology, National Cancer Institute (USA), Dr. David|Longfellow, Project Officer, p. Y91
Timmermans MJ, Delcourt Y (1934). Travaux du Bureau|International D'Etalons Physico-Chimiques|VI Etude des Constantes Physiques de Vingt Composes|Organiques. Journal de Chimie Physique et de Physico-Chimie|Biologique 31, 85-124.
SafePharm Laboratories Limited (1992) Dynasylan IBTEO:|Ninety day sub-chronic (nose-only) inhalation toxicity study|in the rat. Project number 395/6. Degussa-Huls AG-Nr.:|92-0263-DGR December 10, 1992
Ferretti JJ, Wuan LU, Mong-Bing L (1977) Mutagenicity of|benzidine and related compounds employed in the detection of|hemoglobin. Am J Clin Pathol 67: 526-527
Stasenkova KP (1970) Toxic properties of certain stabilisers|for vulcanisates. Sov Rubber Technol 29: 25-26
Rohm and Haas Co. Sub-chronic (90-day) Toxicity Study with Compound 1130-100 in Rats. Report No. R 5226. Study conducted for Cincinnati Milacron Chemicals, Inc. by Centraal Instituut voor Voedingsonderzoek (TNO), Zeist/Netherlands. December 1976.
Salmonella trphimurium TA92, TA94, TA98, TA100, TA1535, TA1537
Litton Bionetics (1983). Evaluation of C-443 in the In Vitro|Transformation of|BALB/3T3 Cells Assay; Litton Bionetics, Inc., LBI Project|No. 20992, March 1983.
Dow Corning Corporation Internal Report Number|1984-I0005-1180.
Method: other: human lymphoblast gene-locus mutation assay, according Thilly et al. (1976), Chem.-Biol. Interact 15, 33-50
National Technical Information Service, Springfield,|VA22161, Formerly U.S. Clearinghouse for Scientific and|Technical Information, AD691-490.
Yakel HO and Kociba RJ (1979) A 10-day repeated inhalation|toxicity study of isooctyl thioglycolate in rats.|Unpublished Dow report.
Method: other: cell transformation assay according Pienta et al., 1977
Haruki, M. (2000) Effects of deicing materials on evergreen|plants in north Japan. Proc. Cold Region Technol. Conf.|2000, 601-605. (in Japanese)
Toxicity to terrestrial plants, IUC4#80/Ch.4.6.2
Miretskaya, L.M. and Shvartsman, P.Y.: Tsitologiya 24,|1056-1060 (1982), No information
Genetic toxicity in vitro, IUC4#131/Ch.5.5
Reported in Du Pont-Haskell Laboratory- Internal DMAC|Review, Oct. 1988 from Anon. (1979). Zhonghua Yufanggixue|Zazhi, 13:39.
LC50 of G124 in rats, Hazelton Laboratories America, |Project No 165-163, October 1976.
BASF AG (1963) Toxicity of choline chloride 70% in water;|skin irritation after exposure to choline chloride.|Department of Toxicology, unpublished results, Study No.|XIII 9, 01.03.1963
According to the 24 hour cuff method (Draize, et al.,). Groups of four male albino New Zealand rabbits (2.5 to 3.5 kg) had the fur removed from the entire trunk by clipping. The administered dose was retained beneath an impervious plastic film. The an
Hardin B.D. et al, 1987, Terat. Carc. Mutagen., V7,|P.29-48 and 85-94.
Foureman P. et al.: Env. Molec. Mutagenesis 23, 51-63,|(1994)
Genetic toxicity in vivo, IUC4#21/Ch.5.6
Dore, M., Brunet, N., Legube, B. (1974) Participation de|differérents composés organiques à la valeur des critè
Biodegradation in water: screening tests, IUC4#50/Ch.3.5
Suk WA, Humphreys JE (1985) Assay for the carcinogenicity of|chemical agents using enhancement of anchorage-independent|survival of retrovirus-infected Fischer rat embryo cells.|Prog Mut Res 5: 673-683
Method: other: Anchorage-independent survival assay according Suk et al., 1984
Genetic toxicity in vitro, IUC4#84/Ch.5.5
Patty's Industrial Hygiene and Toxicology (1982), 3rd|Edition. Volume 2C, p. 4578. John Wiley and Sons.
Drottar, K.R., Swigert, J.P., 1993. Methyl Bromide: A|96-Hour Static Acute Toxicity Test with the Rainbow Trout|(Oncorhynchus mykiss), Final Report. Unpublished report from|Wildlife International, Ltd. Project No. 264A-105A.
Bayer AG, Herbold BA (1992) p-Choronitrobenzene, Sister|chromatid exchange in bone marrow of chinese hamsters in|vivo. Report No. 21020, January 28, 1992
EPA OTS 798.5915 (In Vivo Sister Chromatid Exchange Assay)
Basketter DA, Sanders D, Jowsey IR (2007) The skin sensitization potential of resorcinol: experience with the local lymph node assay. Contact Dermatitis 56:196-200.
Hoy, C.A. et al.: Mutat. Res. 130, 321-332 (1984), No information
Method: other: differential cell killing (DNA damage)
Genetic toxicity in vitro, IUC4#226/Ch.5.5
Brown D and Laboureur P (1983). The aerobic biodegradability|of primary aromatic amines. Chemosphere 12 (3), 405-414.
Method: other: according to Hera, C. and Pueyo, C.: Mutagenesis 1, 267-273
Davidenko AV, Vasil ev AN, Kucherenko-N-E. (1984)|(Functioning of the systems of neuromediator inactivation in|the brain terminals of rats chronically exposed to|terephthalic acid and its dimethyl ester). Biol Nauki ISS 1|31-4
Kutzman R S and Drew R T (1986). A study of Fischer-344 rats|and B6C3F1 mice exposed to cobalt and/or tungsten carbide|dusts for three months. Conducted for the National|Toxicology Program at Brookhaven National Laboratory,|Unpublished Report No. BNL 37570; February 1986.
Xiong J, Minagawa J, Crofts A, and Govindjee (1998). Loss of|inhibition by formate in newly constructed photosystem II D1|mutants, D1-R257E and D1-R257M, of Chlamydomonas|reinhardtii. Biochimica et Biophysica Acta 1365, 473-491.
Toxicity to aquatic algae and cyanobacteria, IUC4#8/Ch.4.3
Covance Laboratories (1998). LHS Super. Skin sensitisation|study in the Guinea pig. Unpublished final study report No.|1516/22-1032 dated January 1998. Sponsored by Hydro|Nutrition, Oslo.
HSDB (2002): Sodium Sulfite. Hazardous Substances Data Bank,|Last revision 11/08/2002.
BASF AG, Department of Toxicology, unpublished data,|(XIII/27), 11 Apr. 1963
Sorbe, Sicherheitstechnische Kenndaten chemischer Stoffe, p.|490, 80. Erg. Lfg. 2/2001
Scopas Technology Company (1986). Mutagenicity of chlorine|dioxide in an in vitro cytogenetic assay measuring|chromosome aberration frequencies in Chinese Hamster Ovary|(CHO) cells. Litton Bionetics Inc, report n°= 20990.
EPA OTS 798.5375 (In Vitro Mammalian Chromosome Aberration)
Report to Montefibre from Biffi (1995). DMAC: |Biodegradation by modified MITI test. Biolab Report n.|94/20164:1-8.
Method: other: Directive 92/69/EEC, part 7, pag. 216 (MITI I)
Patty's Toxicology (2001). Fifth Edition, Volume 5, edited|by Bingham E, Cohrssen B, and Powell CH. Joh Wiley & Sons|Inc., New York, USA, 691.
Data from isobutanol in vivo genetic toxicity studies have been included in this section. Data from isobutanol is useful when assessing the hazard associated with isobutyl isobutyrate exposure due to the rapid and complete hydrolysis of isobutyl isobutyrate to isobutanol in vivo. There are no in vivo genetic toxicity studies conducted with isobutyric acid. The toxicokinetics of the metabolism is documented and explained further in the Toxicokinetics Section (5.10.B).
Heck, H. d'A., and Tyl, R.W. (1985) The induction of bladder|stones by terephthalic acid, dimethyl terepthalate, and|melamine (2,4,6-triamino-s-triazine and its relevance to|risk assessment. Regul. Toxicol. Pharmacol. 5, 294-313.
Institut Fresenius (2000) Study on the Acute Toxicity|towards Daphnia of 3-Mercaptopropionic Acid according to|OECD Test Guideline 202 Part I (1984). Study Number|IF-99/21946-00
Dearman R.J., Basketter D.A., Evans P., and Kimber I.|(1999). Comparison of cytokine secretion profiles provoked|in mice by glutaraldehyde and formaldehyde. Clin.Exp.Allergy|29, 124-132., No information
Purchase IFH, Longstaff E, Ashby J, Styles JA, Anderson D,|Lefevre PA, Westwood FR (1978). An evaluation of 6|short-term tests for detecting organic chemical carcinogens.|Br. J. Cancer 37, 873-903.
Method: other: the tetrazolium reduction test, see also freetext ME
BASF AG, Safety data sheet 2-Methyl-3-butin-2-ol, 17.09.1996
Dorman DC, Bolon B, Struve MF, LaPerle KMD, Wong BA, Elswick|B, and Welsch F (1995). Role of formate in methanol-induced|exencephaly in CD-1 mice. Teratology 52, 30-40.
Hellmer L, Bolscfoldi G (1992) An Evaluation of the E.coli|K-12 uvrB/rec DNA repair Host-Mediated Assay. Mut Res 272:|145-160
Kerns, W.D. et al.: Cancer Res. 43, 4382-4392 (1983), No information
Hall, 1979, Unpublished report from McCormick & Co. Inc. to the flavor and extracts manufacturers' association of the United States, McCormick & Co. Inc. to the flavor and extracts manufacturers' association of the United States, Washington DC, US
H. C. Starck (2004). Material Safety Data Sheet of Tungsten|carbide DS 80 (475223/01).
Method: other: Liquid Preincubation Test
Genetic toxicity in vitro, IUC4#258/Ch.5.5
Sleight BH, Macek KJ (1972) TINOPAL AMS: Exposure of fish to|FA-13: Accumulation, Distribution and Elimination of|Residues. Bionomics Inc., 790 Main Street, Wareham,|Massachusetts (USA)
Method: other: Mount DI, Brungs WA; Simplified Dosing Apparatus for Fish Toxicology Studies. Water Research 1:21 (1967)
Bioaccumulation: aquatic / sediment, IUC4#11/Ch.3.7
BASF AG (1972). Department of Technical Development, report|No. 172.296.1, 21 Jun 1972, unpublished.
Lyman W.J.; Reehl W.F.; Rosenblatt D.H.: Handbook of|Chemical Property Estimation Methods. American Chemical|Siciety, Washington, DC (1990).
Monsanto Chemical Co. (1976) unpublished study Project LBI|No. 2683 12/76 (BIO-76-227). Cited in letter from BGVV|06.05.1996
Gelest, Inc. 1999. Material Safety Data Sheet. Di-n-Butyl (Maleate) Tin - SND3320. http//www.gelest.com/gelest/gelest1/msds.asp?SND3320 (accessed December 2, 1999).
Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA1538; Escherichia coli WP2 uvrA
Bayer AG, Internal study: Identity and Material Balance of|o-Chloronitrobenzene (25.08.89)
Faed, M.J.W. and Mourelatos, D.: Mutat. Res. 49, 437-440|(1978);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Salmonella typhimurium strains TA 1535, TA 1537, TA 1538, TA 98, TA 100
Shirai, T. et al. (1982): Food Chem. Toxicol. 20, 861 - 865
Vogel E (1976). Mutagenicity of carcinogens in Drosophila as function of genotype-controlled metabolism. In: De Serres FJ, Fouts JR, Bend JR, Philpot RM (Eds.), In Vitro Metabolic Activation in Mutagenesis Testing, Elsevier North-Holland Biomedical Press, Amsterdam, 63-79.
Method: other: test substance dissolved in DMSO and diluted in 5 % sucrose solution
Koreshkova S.V. et al.: Russian J. Genetics 31, 736-739,|(1995)
Genetic toxicity in vitro, IUC4#69/Ch.5.5
Wuergler, F.E. et al., Prog. Mutat. Res. 5, 325-340 (1985)
Christ, RA: Die Wirkung von Organischen Substanzen|(Losemitteln) in der Gasphase auf hohere Planzen.|Gefahrstoffe - Reinhaltung der Luft, 56: 345-350 (1996).
Takahashi, O., Hiraga, K. (1978): Toxicol. Appl. Pharmacol.|43, 399 - 406
Repeated dose toxicity: oral, IUC4#23/Ch.5.4
Ewell, W.S. et al., Environ. Toxicol. Chem. 5, 831-840|(1986)
Suzuki J et al.: Formation of Mutagens by Photochemical|Reaction of 2-Naphthol in Aqueous Nitrite Solution (1988).|Chem Pharm Bull 36, 2204-2211.
Method: other: preincubation method (Maron and Ames, Mutat Res 113, 173, 1983)
Genetic toxicity in vitro, IUC4#39/Ch.5.5
Rank, J. and Nielsen, M.H.: Mutat. Res. 312, 17-24 (1994), No information
Method: other: Anaphase-telophase test aberrations - eukaryotes (plants)
Genetic toxicity in vitro, IUC4#99/Ch.5.5
Lyman WF, Reehl WF, and Rosenblatt DH (1990). Handbook of|Chemical Property Estimation Methods. American Chemical|Society, Washington DC.
Salmonella typhimurium TA97, TA98, TA100, TA102, TA104, TA 2638, UTH8413, UTH 8414
Rohm & Haas Co.,"Teratological Evaluation o n-Butyl Acrylate|in CD-1 Mice", Research Triangle Institue, Contract No.|N01-ES-6-2127, Sept. 13, 1982
Marhold JV (1972). Sbornik Vysledku Toxikologickeho|Vysetreni Latek A Pripravku, Institut Pro Vychovu Vedoucich|Pracovniku Chemickeho Prumyslu, Praha, Czechoslovakia, 68.
BUA report 108 Tributyl Phosphate GDch-Advisory committee on Existing Chemicals (BUA): S. Hirzel Verlag
OECD Guideline 305 E (Bioaccumulation: Flow-through Fish Test)
Bioaccumulation: aquatic / sediment, IUC4#60/Ch.3.7
Method: other: (calculated): Epiwin Version 2.0, Syracuse Research Corporation, Environmental Science Center Merill Lane, Syracuse, NY 13210, 1996
Amoco Corporation (1975) Eye Irritation Test with|Terephthalic Acid in Rabbits. IBT Study #601-06339
Monsanto (1981) Environmental Fate Screening of Santoflex|13. Unpublished study ES-81-SS-52
Method: other: River die-away in Mississippi River water
Salmonella typhimurium (strains TA 98, TA 100, TA 1535 and TA 1537) and Escherichia coli WP2 uvrA
Hecht SS, El-Bayoumy K, Rivenson A, Fiala E (1982)|Comparative carcinogenicity of o-toluidine hydrochloride and|o-nitrosotoluene in F344 rats. Cancer Lett 16: 103-108
Dowd, M.A. et al.: Environ. Mutagen. 6, 441 (1984);|abstractFd-7, No information
Genetic toxicity in vitro, IUC4#111/Ch.5.5
Short-term toxicity to fish, IUC4#43/Ch.4.1
BASF AG, Department of Toxicology, Ergebnis der|gewerbetoxikologischen Grundprüfung, unpublished report|(XXI/56), 23 Jul. 1971
McGregor D.B. (1981), IRI report to NIOSH NTIS no.|PB86-239845, Jul 1.
Crompton GmbH. 2001. Melting points and boiling points of organotin mercaptides. Personal communication from P. Schultze (Crompton) to Parametrix, Inc. 23.10.01.
Boatman RJ and Knaak JB. 2001. Ethers of ethylene glycol and derivatives. Chapter 86 in Volume 7 of Patty's Toxicology, Fifth Ed. (ed. E. Bingham, B. Cohrssen, and CH Powell), John Wiley and Sons, Inc. New York.
Sicherheitsdatenblatt, Peroxid-Chemie GmbH, Ausgabe 2/95
Deneer JW, Sinnige TL, Seinen W, Hermens JLM (1987)|Quantitative Structure-Activity Relationships for the|Toxicity and Bioconcentration Factor of Nitrobenzene|Derivatives Towards the Guppy (Poecilia reticulata). Aquat|Tox 10: 115 - 129
Elf Atochem (1978) Acute toxicity tests on rats oral and|percutaneous administration, IFREB report no. 801264, 26|january 1978.
Method: other: equivalent to OECD Guide-line 402
Mellon Institute of Industrial Research (1962).|Range-Finding Tests of Glycidoxy Propyltrimethoxysilane,|Report 25-52; June|22, 1962.
Brown B. et al.: J. Pharmacol. Exp. Ther. 115, 230-239,|(1955); |cited in: BG Chemie, Datenkatalog Nr. 205
Shibuya T. et al., Hatano Research Institute, Food and Drug Safety Center, Japan (1996). Micronucleus test of N-(aminoethyl)ethanolamine on mice. |In: Ministry of Health and Welfare, Japan (1996) Toxicity|Testing Reports of Environmental Chemicals, Vol. 4, 371-376.
Doolittle D., The genotoxic activity of glycerol in an in|vitro test battery, Fd Chem Toxic 26(7): 631-635, 1988 (39)
BASF AG (1979) Bericht über die gewerbetoxikologische|Grundprüfung. Unveroeffentlichte Untersuchung der Abt.|Toxikologie (77/448, 06.09.1979)
Method: other: Draize Test according Fed. Reg. 38, No. 187, §1500.42, p. 27019, 1973 see also freetext ME
BASF (2003) Calculation of photodegradation in air. BASF AG,|Department of Ecology, 05.08.2003 (unpublished data)
Phototransformation in air, IUC4#12/Ch.3.1.1
Innes JRM, Ulland BM, Valerio MG, Petrucelli L, Fishbein L,|Hart ER, Palotta AJ, Bates RR, Falk HL, Gart JJ, Klein M,|Mitchell I, Peters J (1969) Bioassay of pesticides and|industrial chemicals for tumorigenicity in mice: a|preliminary note. J Nat Canc Inst 42: 1101-1114
Method: other: modification of the method described by Zimmermann (1975)
Ciba-Geigy Ltd., TK 10044, 21 days aerosol inhalation study|in rats, Project No 441678, 9.7.1979.
Method: other: Sachsse et al. (1973,1976)
Developmental toxicity / teratogenicity, IUC4#22/Ch.5.8.2
Loeser E (1978a). Bayer AG data, Akute orale Toxizität,|November/09/1978.
BASF AG, Department of Toxicology, unpublished results,|(XIX/422), 02 Dec. 1971
Method: other: Guideline for Reproduction Studies for Safety Evaluation of Drugs, FDA/USA, 1966
Developmental toxicity / teratogenicity, IUC4#14/Ch.5.8.2
Method: other: OECD Proposal (1979: Report on the Assessement of Potential Environmental Effects of Chemicals I
Heisler E and Dickhaus S (1990). Augenreiztest am Kaninchen|mit dem Produkt Betolin K28 - 100% - nach Draize. Pharmatox|Beratung und Forschung GmbH, Report no. 1-3-35-90.
FMC, Toxicology Department, Princeton; letter of March 8,|1994 (1994).
Ministry of Health and Welfare, Japan: Toxicity Testing|Reports of Environmental Chemicals, 6, 381-398(1998)
Verschueren Handbook of Environmental Data on Organic|Chemicals, 3rd Ed.
Nolen GA, Gibson WB, Benedict JH, Briggs DW and Schardein JL. 1985. Fertility and teratogenic studies of diethylene glycol monobutyl ether in rats and rabbits. Fund Appl Toxicol 5: 1137-1143.
Enslein, K. et al.: QSAR envir. Toxic. Proc. 11, 91 (1987)|cited in BIBRA Toxicity Profile (1991)
Bayer AG (2001) Material Safety Data Sheet|1,2-Dichloro-4-nitrobenzene (2001-11-06)
Allied Corporate Medical Affairs (1979) Mammalian Cell Mutagenicity of Four Toluene Diamine Isomers. EPA Document No. 40-8336132, Fiche No OTS0506071. (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com)
Yamamoto T., M. Wakazono, and K. Katsuyama. 1992. Yoshitomi Pharmaceutical Ind. Ltd. A List of Organotins Toxicity Data. 19.11.1992. (unpublished report)
Maurer, T. and Hess, R.: Fd. Chem. Toxic. 27, 807-811|(1989);|cited in: IPCS Environ. Health Crit. 89, (1989), No information
Kinkead E, et al. (1971). The mammalian toxicity of|ethylidenenorbornene [5-Ethylidenebicyclo(2,2,1)hept-2-ene].|Toxicol. Appl. Pharmacol. 20, 250-259.
Monsanto Study SA-44, April 1954, Scientific Associates Lab. as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Method: other (calculated): modified Grain method (MPBPWIN v1.41.)
Parry JM (1985) Summary Report on the performance of the|yeast cell and Aspergillus assays. Prog Mut Res 5: 25-46
Genetic toxicity in vitro, IUC4#66/Ch.5.5
BASF (1981) Zahn-Wellens test (mucochloric acid). BASF AG,|Dpt. of Ecology, 07.05.1981 (unpublished data; Reprint|05.07.2002)
Biodegradation in water: screening tests, IUC4#25/Ch.3.5
Elmore E, Korytynski EA, Smith MP (1985) Evaluation of three|"difficult to test" carcinogens in the Chinese hamster V79|inhibition of metabolic cooperation assay. Environ Mutag 7:|3, 61
Genetic toxicity in vitro, IUC4#132/Ch.5.5
Genetic toxicity in vivo, IUC4#56/Ch.5.6
Graham RC, Snyder SW, Montgomery RR (1982) Toxicity summary|of p-Nitrochloro-benzene, compiled by DuPont Haskell|Laboratory: cited in US EPA Chemical Hazard Information|Profile Draft Report|4-Chloronitrobenzene, June 13, 1983, Office of Toxic|Substances, EPA, USA
Bathe R (1980) FAT 65'023/K: Report on oral LD50 in the rat.|CIBA-GEIGY Ltd., CH-4002 Basel (Switzerland)
Method: other: internal method of CIBA-GEIGY
NTP (1993) 2-Chloronitrobenene and 4-Chloronitrobenzene:|Administered by inhalation to F344/N rats and B6C3F1 mice.|Toxicity Report Series No. 33, NIH Publication, 93-3382,|July/1993
Method: other: feeding: 4 day old males (24 hrs old for feeding, 72 hrs exposure) were mated; injection: 1-3 d old; 24 hrs after exposure mated, primarily post-meiotic germ cells were tested.
Daniel MR, Dehnel JM (1981) Cell transformation test with|baby hamsterkidney cells. Prog Mut Res 1: 626-637
Method: other: according Styles, 1977, Br. J. Cancer 36, 558
Jenner, P.M. et al. (1964), Food Flavourings and Compounds|of Related Structure I. Acute Oral Toxicity, Fd Cosmet.|Toxicol. 2, 327-343
Marshall, T.C. et al.: "Subchronic inhalation exposure of|guinea pigs to formaldehyde", Inhalation Toxicology|ResearchInstitute Annual Report, LMF-102, UC-48 (1982), pp.|423-427, No information
Method: other: exposure period 24 hours, no further data
Skin irritation / corrosion, IUC4#70/Ch.5.2.1
Hoechst AG (1995): EG-Sicherheitsdatenblatt beta-Naphthol|flüssig (06.06.1995)
Hoechst AG (1978): Unveröffentl. Unters. (Ber.-Nr. 78.0497)
Chemicals Evaluation and Research Institute (CERI), Japan.|(2005). Study Note of 4-Ethyl morpholine.
Mellon Institute of Industrial Research (1962) Special|Report: Range Finding Tests on Trimethoxysilane. Report|25-22 April 3, 1962
Bringmann G and Kuehn R (1977). Grenzwerte der Schadwirkung|wassergefaehrdender Stoffe gegen Bakterien (Pseudomonas|putida) und Gruenalgen (Scenedesmus quadricauda) im|Zellvermehrungshemmtest. Z. Wasser- Abwasser-Forsch. 10|(3/4), 87-98.
SKW Trostberg AG: SUMMARY DATA SHEET "P-SDS" (Nov.09.2000)
Industrial Biology Laboratories Inc, Shelanski MV (1964 c)|Repeated insult patch test. Study report Project No.|SH-64-4. Unpublished study of Monsanto Chemical Co
Cannon Laboratories, Inc. 1979. Acute Oral Toxicity of: 1185-13 (Dioctyltin Dichloride), 28G082, 28HO47, 1185-114, 1219-21 (Dimethyltin Dichloride), 1185-150, 1185-119 and 1185-138 in Weanling Sprague-Dawley Rats. 21.3.1979.
König GM, Wright AD, de Nys R (1999): Halogenated|monoterpenes from Plocamium costatum and their biological|activity. J Nat Prod 62: 383-385.
Ishidate, M., Sofuni, T., Yoshikawa, K. (1981): Chromosomal|aberration tests in vitro as a primary screening tool for|environmental mutagens and/or carcinogens. Monograph on|Cancer research, 27, 95-108.
Bringmann,G., Kuehn,R., Zeitschrift fuer Wasser- und|Abwasser-Forschung, 10(3/4), 87-98, (1977)
Lewis,S.J.et al. (1983): Quant. Struct. Act. Relat. 2, 100-111
Method: other (measured): Flask shaking Method
Degussa AG (1978). Prüfung von Calciumformiat im|Augenreiztest am Kaninchen. Degussa AG -US -IT-Nr. 0016 DKT.
Method: other: cultivation methode (Screeningtest)
Yoshioka, Y. and Ose, Y., Environmental Toxicology and|Water Quality: An International Journal 8(1), 87-101|(1993)
Dupont, 1976, cited in HEDSET by ISP Europe, April 1994
Flick EW. (ed.). 1991. Industrial Solvents Handbook 4th Ed.|Noyes Data Corporation., Park Ridge, NJ., p. 564.
Dawson, G.W., Jennings, A.L., Drozdowski, D., Rider, E.|1975/77. The acute toxicity of 47 industrial chemicals to|fresh and saltwater fishes. J. Hazard. Mater., 1: 303-318.
He Y, Zhou J, Zhong X, Yang X, Ou P, Zhang Y, Liang Y|(1989). Toxicity of phosphorus trichloride. Weishieng|Dulixue Zazhi 3, 215-218.
Hardin, B.D., Bond, G.P., Sikov, M.R., Andrew, F.D.,|Beliles, R.P., Niemeier, R.W., 1981. Testing of selected|workplace chemicals for teratogenic potential. Scand. J.|Work Environ. Health 7:66-75.
McGregor DB and Ainsworth L. Lack of mutagenic|activity in Salmonella typhimurium of four optical|brighteners. Mutation Research, 40:169-172, 1976.
Reported in HSDB-Data Bank from Atkinson R. (1987).|Int. J. Chem. Kinet., 19:799-828.
Weigand M., Mayer D.,(1977), Haut- und Schleimhautvertäg von|Echtorange GR Base. Bericht (77.0610), unveröffentlitche|Ergebnisse der Hoechst AG.Hoechst AG (1977):|Unveröffentlichte Untersusuchung (77.0610)
Levi-Minzi R, Saviozzi A, and Riffaldi R (1994). Organic|acids as seed germination inhibitors. Journal of|Environmental Science and Health, Part A: Environmental|Science and Engineering A29(10), 2203-2217.
Burg AW, Rohovsky MW, and Kensler CJ. Current status of|human safety and environmental aspects of fluorescent|whitening agents used in detergents in the United States.|CRC Critical Reviews in Environmental Control, April 1977.
Garner R.C., Nutman C.A. (1977), Testing of some azo dyes|and their reduction products for mutagenicity using|Salmonella typhimurium TA1538: Mut. Res. 44, 9-19
Data Sheet No. 230 (1992). Kommission Bewertung|wassergefährdender Stoffe. Bundesgesundheitsamt, P.O. Box|330013, D-14191 Berlin
Tegner, E., Acta Derm. Venereol. (Stockholm), 65, 254-257|(1985)
Fukuda K and Takemoto K (1980) Species difference and|concentration-effect relationship in cancers inducet by|inhalation of benzotrichloride (BTC). The 44th General|Meeting of the Japanese Cancer Association
Danse, L.H.J.C., Van elsen, F.L., Van der Heijden, C.A.,|1984. Methyl bromide: carcinogenic effects in the rat|forestomach. Toxicol. Appl. Pharmacol., 72: 262-271.
Salmonella typhimurium TA100, TA1535, TA1537, TA98
Kramer JB (1996). Photodegradation of fluorescent whitening|agents in sunlit natural waters. Env. Sci. and Technol.|Dissertation submitted to the Swiss Federal Institute of|Technology Zurich, 123 pp.
Biodegradation in water: screening tests, IUC4#200/Ch.3.5
BASF AG (1989). Department of Analytical Chemistry, report|BRU 89.025, 06 Feb 1989, unpublished.
Method: other (measured): comparable to OECD 107
Bayer AG (1991). Anaerobic degradation of DNT according to|EPA-guideline 796.3140, Unpublished Report (No 174 A/90).
Method: other: according to EPA Test Guideline (§ 796.3140 "Anaerobic biodegradability of organic chemicals")
Kimmerle G and Solmecke B (1972). Isopren-Akute Toxizit,|tsuntersuchungen. Bayer AG, unveroffentlichter Bericht Nr.|3373.
MHLW (Ministry of Health, Labour and Welfare), Japan (2005)|Unpublished data performed by An-pyo Center (Exp.No. 7818|(115-183).
Method: T37-15:OECD Guideline 474 "Mammalian Erythrocyte Micronucleus Test"
Leo AJ (1978). Report on the Calculation of Octanol/Water|Log P Values for Structures in EPA Files. as quoted in|ISHOW (2003). CIS, Printing date 04.08.2003
Food and Drug Research Laboratories Inc, Shelanski MV (1972)|Evaluation of dermal effects. Unpublished data of American|Cyanamid Co. NTIS/OTS 206438, EPA/OTS document 878213691|(1983)
Method: other: experiment performed in roller bottles, treatment time: 4 days, metabolic activation by cocultivation with irradated primary Syrian hamster embryo cells
Genetic toxicity in vitro, IUC4#87/Ch.5.5
BASF AG, Department of Toxicology, Report on the study of AEEA in the AMES TEST. Unpublished study no. 40M0233/894484, 18 Apr 1991.
Marhold JV(1972). Sbornik Vysledku Toxixologickeho Vysetreni|Latek A Pripravku, 138
Leopold, W.R., Miller, J.A. and Miller, E.C. (1982) |Comparison of some carcinogenic, mutagenic and biochemical|properties of S-Vinylhomocysteine and ethionine. Cancer|Research 42:4364-4374.
Spencer, W.P., Stern, C., 1948, Genetics 33:43.
Method: other: None specified (this study predates published protocols). No references for methodology were given.
Canton, J.H. et al., Toxicity, Biodegradability and|Accumulation of a Number of Cl/N-Containing Compounds for|Classification and Establishing Water Quality Criteria,|Regulatory Toxicology and Pharmacology 5, 123-131 (1985)
Gonsior SJ and West RJ (1995) Environ Toxicol Chem 14:1273-1279.
Cincinnati Milacron Chemicals, Inc. 1979. Acute Oral Toxicity of: 1185-13, 28G082, 28HO47, 1185-114, 1219-21, 1185-150, 1185-119, and 1185-138 in Weanling Sprague-Dawley Rats. Study conducted by Cannon Laboratories.
Ciba (1989a). Internal report. Analytical Chemistry.|September 21, 1989
Method: other: Ciba internal method IA-123/1
Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA1538, TA97
Bayer AG 1986b, Internal Study, Test on water solubility|(1986-11-12)
Okui, T. and Katakura, Y.: Hokkaidoritsu Eisei Kenkyushoho|39, 110-112 (1989), No information
Method: other: ex vivo (in vitro/in vivo) chromosomal aberrations - eukaryotes (mammalian cells)
Cairns MA and Nebeker AV (1982). Toxicity of acenaphthene|and isophorone to early life stages of fathead minnows.|Arch. Environ. Contam. Toxicol. 11, 703-707.
Long-term toxicity to fish, IUC4#10/Ch.4.5.1
Method: other: Estimated value with PCKOCWIN v. 1.66
Celanese Chemical Company (1976). Product Bulletin on Formic|Acid. Celanese Chemical Company, NY, USA.
Rao K.S. et al.: Drug. Chem. Toxicol. 4, 331-351, (1981)
Method: other: in compliance with Maguire H. C.: J. Soc. Cosmet. Chem. 24, 151, 1973
APCI, Dabco Crystal Toxicity And Irritation Studies,
Geiger, D.L. et al., Acute Toxicities of Organic Chemicals|to Fathead Minnows (Pimephales promelas) Volume III. Center|of Wisconsin-Superior Environmental Studies, University of|Wisconsin-Superior ISBN 0-9614968-2-7 (1986)
Short-term toxicity to fish, IUC4#200/Ch.4.1
BASF AG, Technische Entwicklung Verfahrenstechnik,|Löslichkeitsgleichgewicht, unpublished study, J.No. 19-748,|05 Nov. 1973
Ward, J.B. et al.: Mutat. Res. 130, 417-424 (1984), No information
Repeated dose toxicity: oral, IUC4#45/Ch.5.4
(±)-dihydro-3-hydroxy-4,4-dimethylfuran-2(3H)-one (IUC4 DSN 125)
Dooley, C.A. and P. Kennis. 1987. Response of Bioluminescent Bacteria to Alkyltin Compounds. In Proc. Intern. Organotin Symp. Oceans 87 Conf., Halifax, N.S., Canada. Sept. 28-Oct 1. 4:1517-1524.
Rothkopf GS, Bartha R (1984). Structure-biodegradability|correlations among xenobiotics. Journal of the American Oil|Chemists Society (JAOCS), 61 (5), 977-980.
Salmonella typhimurium; TA1535 TA100 TA1537 TA98
Hoffmann-LaRoche Inc (1967). Acute toxicity, eye and skin|irritation tests on aromatic compounds, unpublished results,|16 Nov. 1967
Method: other: comparable to Draize method
Ashby J, Burlinson B, Lefevre PA, Topham J (1985).|Non-genotoxicity of 2,4,6-Trinitrotoluene (TNT) to the mouse|bone marrow and the rat liver: Implications for its|carcinogenicity. Arch Toxicol 58: 14-19.
Method: other: mainly according to OECD Guide-line 474
2-ethylhexyl 10-ethyl-4,4-dimethyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate (IUC4 DSN 36)
Smyth HF, Jr., Seaton J, Fischer L. 1941. The single dose toxicity of some glycols and derivatives. J Ind Hyg Toxicol 23:259-268.
Ciba (1981) Bioelimination of TK 10027 in the simulation|test - aerobic sewage coupled units test
Biodegradation in water and sediment: simulation tests, IUC4#2/Ch.3.5
Acute toxicity: inhalation, IUC4#23/Ch.5.1.2
Atkinson,R. et al., J. Phys. Chem.88, 1210-1215, 1984 |1989, No information
BASF AG; Abteilung Toxikologie; Unveroeffentlichte Untersuchung (87/556), 06.10.87 cited in IUCLID (2000)
Method: other: according to Ishidate (1985Progress in Mutatio Res. 5, pp,427: see freetext TC
RCC Research and Consulting Company AG (1986). 13-week oral|toxicity (drinking water) study with IPD in the rat. Project|No. 052288 (Hüls AG, unpublished).
Method: other: OECD Guideline 408 (1981)
San and Wagner. 1991. Salmonella/Mammalian-Microsome Plate|Incorporation Mutagenicity Assay (Ames Test) with a|Confirmatory Assay. Microbiological Associates, Inc. |Laboratory Study Number TA039.501014.
Fernandez, M. et al.: Mutat. Res. 292, 83-99 (1993), No information
Method: other: in vivo chromosomal aberrations - eukaryotes (non-mammalian)
Genetic toxicity in vivo, IUC4#34/Ch.5.6
Koopman, T.S.M. and Pot, T.E. (1986) Primary irritation|study of anhydrous calcium chloride to the skin of the male|rabbit. Duphar Report No. 56645/30/86.
Method: other: calculated MPBPWIN (v1.41)
van der Walle H. et al.: Sensitizing potential of 14 mono (meth) acrylates in the guinea pig, Contact Dermatitis, 8, 223-235, (1982)
CIT (1994) Acute eye irritation in rabbits - Isooctylthioglycolate, Centre International de Toxicologie, Report no. 10271 TAL, January 1994.
Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical|Dictionary. 12th ed. New York, NY: Van Nostrand Rheinhold|Co., 1993, p. 779. cited in HSDB 21 Sep 2006
Solubility in organic solvents / fat solubility, IUC4#12/Ch.2.6.1
Method: other: Guideline for Screening Mutagenicity Testing of Chemicals(Chemical Substances Control Law of Japan) and OECD Test Guideline 471
Juhnke, J. and Luedemann, D.: Z. Wasser-Abwasser Forsch.|11,161-164 (1978);|cited in: IPCS Environ. Health Crit. 89, (1989), No information
Short-term toxicity to fish, IUC4#69/Ch.4.1
Method: other: 0.1 ml/rabbit, warmed, observation time: 168 hours
BASF AG (2002). Department of Experimental Toxicology and|Ecology. Formic acid - Buehler test in Guinea pigs.|Unpublished study report on project No. 32H0102/022005,|dated May 29, 2002.
BASF AG (2005). Safety data sheet according to 91/155/EEC,|Formi, revised 05 Sep 2005.
Sax N.I. and Lewis R.J. sr., Dangerous Properties of|Industrial Materials, Seventh Edition, Volume III, p. 3258,|Van Nostrand Reinhold, New York (1989)
CKWitco GmbH. Determination of the Water Solubility of Mono-n-octyltin trichloride. Schering AG. Report No. VE 08/89. 26.04.1989.
Heitmuller PT, Hollister TA, and Parrish PR (1981). Acute|toxicity of 54 industrial chemicals to sheepshead minnows|(Cyprinodon variegatus). Bull. Environ. Contam. Toxicol. 27|(5), 596-604.
Short-term toxicity to fish, IUC4#100/Ch.4.1
Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA1538, 1530, hisG46
Bills,T.D. et al., Invest. Fish Contr. No.73, U.S.D.I. 1-7,|1977, No information
CIBA-GEIGY Ltd. 1992. Report on the test for ready biodegradability in the Modified Sturm Test of Irgastab T 22 M. Test No.: 928294. Basel, Switzerland. 18/09/92.
EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
Rat: hepatocytes, spermatocytes, tracheal epithelial cells
Hoechst AG (1989) Unveröffentlichte Untersuchung (89.0483).
Ministry of Economy, Trade and Industry (METI), Japan. Unpublished report
BASF (1960) Acute toxicity and skin/eye irritation (X/211).|BASF AG, Department of Toxicology, 09.09.1960 (unpublished|data)
Clark, R.L. et al.: Toxicol. Appl. Pharmacol. 91, 371-385|(1987);|cited in: RIFM database, location no. 6084
Developmental toxicity / teratogenicity, IUC4#18/Ch.5.8.2
Reported by Kim S.N.(1988). Drug Metab. Rew., 19:345-368|from Stula E.F. and W.C. Krauss (1977), Toxicol. Appl.|Pharmacol., 41:35.
Ciba-Geigy Ltd., The effect of TK 10044 on selected|biochemical liver parameters following 4-week oral|administration to male and female rats, Laboratory Report|No. CB 90/27 BY, 11.11.1991.
Method: other: mainly according to OECD 407
Bringmann G and Kuehn R (1981). Vergleich der Wirkung von|Schadstoffen auf flagellate sowie ciliate bzw. auf|holozoische bakterienfressende sowie saprozoische Protozoen.|GWF-Wasser/Abwasser 122 (7), 308-313.
Reported by Kennedy G.L. (1986) CRC Crit. Rev. Toxicol.,|17:129-182 from Horn H.J. (1961). Toxicol. Appl. Pharmacol.|3:12-24.
Repeated dose toxicity: dermal, IUC4#8/Ch.5.4
Atkinson,R., Inter. J. Chem. Kinet. 19, 799-828, (1987)
Canadian Centre for Occupational Health and Safety (2001). ChemInfo report for propylene glycol phenyl ether.Record number 197. May 2001
Environmental Protection Service Ottawa (1984) Calcium|chloride; environmental and technical information for|problem spills.
Litton Bionetics, Inc. Project No. 2838; Dow Corning|Corporation internal report no. 1977-I0065-1167-04.
Degussa-Huls AG (1994) Determination of bacterium |toxicity of DYNASYLAN HMDS In Oxygen Consumption |Test (Huls method). Final Report SK-94/15. |Degussa-Huls AG-Nr. 94-0263-DGO 9/16/94.
Method: other: Oxygen consumption test (Huls method)
Ballantyne B, Myers R and Klonne D (1997). Comparative acute|toxicity and primary irritancy of the ethylidene and vinyl|isomers of norbornene. J. Applied Toxicicology 17, 211-221.
Ciba (1989c). Internal report. Physical chemistry. March 2,|1989.
BASF AG, Laboratory of Ecology, unpublished data, |(1988)
Graf, U. and Wuergler, F.E.: Fd. Chem. Toxic. 24 (8),|835-842 (1986)
Method: other: according Fed.Reg.38, No.187, 1973: undissolved test substance, dose: 100 mg/animal, observation time: 24 hrs
Ni, Z. et al. (1993). J. West China Univ. Med. Sci., 24, 82-86.
BASF AG, Department Toxicology, unpublished study,|(XXV/436), 22 May 1978
Method: other: comparable to OECD guideline 407
Andersen, K.E., Hamann, K., Contact Dermatitis, 8, 64-67|(1982) [cited from Hatch and Maibach (1986) and BG Chemie|(1990)]
Toxicity to reproduction, IUC4#4/Ch.5.8.1
BASF AG, 2002, Product Safety, data assessment, SRC PCKOCWIN|v1.66, 16 July 2002
Method: other: calculated using SRC PCKOCWIN v1.66
Monsanto Study No. BO-76-181 as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Anjaneyulu Y, Rekha TM (2000) Studies on the dynamics of|certain persistent hazardous organics (halo and nitro|aromatics) on various types of soils and their in-situ|biodegradation. Res J Chem Environ 4 (3): 45 - 61
Monsanto Co (1983a) Acute dermal toxicity (albino rabbits)|p-Nitrochlorobenzene. (Test# YO-83-017), 29.08.1983,|EPA-OTS0557080
Method: other: 2 rabbits /sex/dose, single dermal application, exposure: 24 hours, 14 day post exposure observation, gross necropsy
Buehler, E.V.: Arch. Dermatol. 91, 171-177 (1965), No information
Kirk-Othmer Encyclopedia of Chemical Technology. 4th ed.|Volumes 1: New York, NY. John Wiley and Sons, 1991-Present.,|p. V20 (96) 714. cited in HSDB 21 Sep 2006
Union Carbide Corporation.1941. Unpublished data.
IIT Research Institute. 1991. Acute Oral Toxicity Study of|Trimellitic Anhydride in Rats. IITRI Project No. L08100,|Study No. 1699.
Bringmann G and Kuehn R (1980). Bestimmung der biologischen|Schadwirkung wassergefaehrdender Stoffe gegen Protozoen II.|Bakterienfressende Ciliaten. Z. Wasser Abwasser Forsch. 1,|26-31.
Method: other: Inhibition of cell reproduction acc. to Bringmann & Kühn
OECD Guideline 479 (Genetic Toxicology: In Vitro Sister Chromatid Exchange Assay in Mammalian Cells)
Pozzani, U.C., C.S. Weil and C.P. Carpenter
CIT (1993) Acute dermal irritation in rabbits with|2-ethylhexyl thioglycolate, CIT study no. 10266 TAL, 31|December 1993.
BASF AG, Safety data sheet BUTYL ACRYLATE, 27.07.2005
Patrick, , R., Cairns, Jr., J., Scheier, A. (1968). The|relative sensitivity of diatoms, snails and fish to twenty|common constituents of industrial wastes. Prog. Fish-Cult.|30(3):137-140.
M&T Chemicals, Inc. 1978. Acute oral toxicity study in rats - Thermolite 15, JCRDY-611K, 4201. Project Number 4542-77. Study conducted by Bio/Dynamics, Inc. Toxicological Resources Unit. January 4, 1978.
BASF (1989) Partition coefficient. BASF AG, Analytical|laboratory, 09.01.1989 (unpublished data)
Method: other (calculated): Increment method by Rekker with computer programme of firm CompuDrug Ltd.
Kane, L.E. and Alarie, Y.: Am. Ind. Hyg. Assoc. J. 3,|509-522 (1977);|cited in: Schaper, M.: Am. Ind. Hyg. assoc. J. 54 (9),| 488-544 (1993), No information
Fassett, D.W. (S.1968): Industrial Hygiene and Toxicology,|Ed. Patty, F.A. New York-London-Sidney (1962)
Ema, M., R. Kurosaka, H. Amano, and Y. Ogawa. 1996. Comparative developmental toxicity of di-, tri-, and tetrabutyltin compounds after administration during late organogenesis in rats. Journal of Applied Toxicology. 16(1):71-76.
Auer (1989). Auer-Technikum, Ausgabe 12, 380-385. Auer-Gesellschaft mbH, Berlin.
Directive 87/302/EEC, Part C, page 89-94 Algal inhibition test
Furukawa A, Ohuchida A (1991) Mutagenicity test of polyploid|inducers. Mutat Res 252: 86-87
BASF (1983) "Bericht ueber die Pruefung von Loesungsmittel PM in AMES test (Standard plate test mit Salmonella typhimurium)", unpublished report.
Givaudan, 1994, Corporate Safety & Environmental Affairs,|Partition coefficient n-octanol/water of IONONE BETA SYNT|according to OECD Guideline No. 117, unpublished study, 02|Nov. 1994
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.10,61,1954. as cited in IUCLID.
Acute toxicity: inhalation, IUC4#60/Ch.5.1.2
Auletta CS, Schroeder RE, Krasavage WJ, Stack CR. 1993. Toxicology of diethylene glycol butyl ether. 4. Dermal subchronic/reproduction study in rats. J Am Coll Toxicol.|12: 161-168.
Union Carbide Corporation. Chemical Hygiene Fellowship. |Project Report No. 34-41. Export, PA. 1971.
Dunlop, M. and Court, J.M.: Biol. Neonat. 39, 178-184|(1981);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Weast, R..C. Handbook of Chemistry and Physics. The Chemical|Rubber Co., 18901 Cranwood Parkway, Cleveland, Ohio, 44128.|1970-1971
ETAD (1998). Breslin WJ. A pilot prenatal developmental|toxicity study via oral gavage to rats. MPI Research|Laboratory Study Identification 795-001, August 18, 1998.
Matsui S, Okawa Y, and Ota R (1988). Experience of 16 yearsoperation and maintenance of the Fukashiba industrial|wastewater treatment plant of the Kashima petrochemical|complex - II. Biodegradability of 37 organic substances and|28 process wastewaters. Water Sci. Technol. 20, 201-210.
Biodegradation in water: screening tests, IUC4#24/Ch.3.5
Salanitro, J.P. et al., Water Sci. Technol. 20, 125-130|(1988)
Rasmuson, A. and Larsson, J.: Mutagenesis 7, 219-223 (1992), No information
Method: other: unstable zeste-white test
Turck PA. Prenatal developmental toxicity study of C.I.|Fluorescent Brightener 220 administered via oral gavage to|rats. Report Laboratory Study No. 795-003, December 2, 1999.|MPI Research, Mattawan, USA.
EPA OPPTS 870.3700 (Prenatal Developmental Toxicity Study)
Bringmann,G., Kuehn,R., Z. Wasser Abwasser Forschung 1,|26-31, 1980, No information
Bringmann G., Kühn R. Comparison of the Toxicity Thresholds of Water Pollutants to Bacteria, Algae and Protozoa in the Cell Multiplication Inhibition Test. Water Research 14:231-241. 1980.
Toxicity to aquatic algae and cyanobacteria, IUC4#50/Ch.4.3
Food and Drug Research Laboratories, Inc., Teratologic|evaluation of FDA 71-37 (Sodium benzoate). East Orange, New|Jersey, Food and Drug Administration, Washington, D.C., PB|221777 (1972)
Aldrich Chemical Co., Inc. Product No. 201057 (Butyltin trichloride, 95%). Material Safety Data Sheet. 11.1999-01.2000. The Sigma-Aldrich Catalog - Online. http://www.sigma-aldrich.com/sacatalog.nsf/productlookup/Aldr201057?OpenDo cument/Applogic+MSDSInfo.ReturnMSDS?ProductNo2157 (accessed December 3, 1999).
Microbiological Associates Inc., Study No. T9145.337,|July 17 (1990) (at the request of Synthetic Organic|Chemical Manufacturers Association Inc.).
Short-term toxicity to aquatic invertebrates, IUC4#48/Ch.4.2
Skin irritation / corrosion, IUC4#11/Ch.5.2.1
Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E (1983)|Salmonella mutagenicity test results for 250 chemicals.|Environ Mutagenesis 5, Suppl 1: 3 - 142
Method: other: preincubation methodology according to Ames BN et al. (1975) Mutat Res 31, 347-364 and Yahagi, Cancer Lett.1, 91 (1975), see also freetext ME
Rudio J (1999): Ready biodegradability of Isophytol rect.|according to OECD Guideline No. 301 F. Test report No.|99-E72, 14 September 1999. Givaudan Roure SA, CH-1214|Vernier/Geneva, Switzerland, unpublished.
Veith, G.D. et al. (1979) J.Fish Res.Board Can., 36, 1040-1048.
BASF AG (1963) Toxicity of choline chloride 70% in water;|eye irritation. Department of Toxicology, unpublished|results, Study No. XIII 9, 01.03.1963
S. typhimurium TA 100, TA 1535, TA 1537, TA 9
Slaga TJ, Triplett LL, Smith LH, Wischi, HP (1985)|Carcinogenesis of nitrated toluenes and benzenes, skin and|lung tumor assays in mice. Oak Ridge National Labortory|Report No AD-A 155723, ORNL/TM 9645
Method: other: tumor initiation promotion test
Wang Y, Wang Z, Wang C, Wang W (1998) Uptake of Weakly|Hydrophobic Nitroaromatics from Water by semipermeable|Membrane Devices (SPMDs) and by Goldfish (Carassius|auratus). Chemosphere 38 (1): 51 - 66
Lomonova, G.V. & Preobrazhenskaya, A.A., zitiert nach:|Questions of Working Hygiene and Clinic of Occupational|Diseases, Gorky, 34-40 (1961). In: Izmerov, N.F. (ed.),|IRPTC, Vol. 35: Caprolactam, Centre of International|Projects, Moscow (1983)
Leonard TB, Graichen ME, Popp JA (1987). Dinitrotoluene|isomer-specific hepatocarcinogenesis in F344 rats. JNCI 79,|1313-1319.
Method: other: bioassay for hepatocarcinogenicity
Degussa AG, unpublished report, 1979, Acute oral toxicity in rats. Degussa Report No. 79-0038-DKT
USEPA (2009) Estimations Programs Interface (EPI) Suite™ for Microsoft Windows®, v4.00. United States Environmental Protection Agency, Washington, DC, USA.
Method: other (calculated): AopWin v1.92
Dow Corning Corporation (2001) Physical properties database.
Method: other: Extrapolation of lower, ebulliometric boiling points
Schwanitz (1979) Persoenliche Mitteilung; cited in: Luepke, Preusser (1979): Aerztl. Kosmetol. 9:341-346.
Genetic toxicity in vitro, IUC4#25/Ch.5.5
Trénel, J. and Kühn, R., Bewertung wassergefaehrdender|Stoffe im Hinblick auf Lagerung, Umschlag und Transport und|Untersuchung zur Abklaerung substanz- und|bewertungsmethodenspezifischer Grenzfaelle bei der Bewertung|wassergefaehrdender Stoffe. Umweltforschungsplan des|Bundesministers des Innern, Forschungsbericht. Institut fuer|Wasser-, Boden- und Lufthygiene des Bundesgesundheitsamtes,|1-47, Berlin (1982)
Method: other (calculated): MPBPWIN v. 1.40 in EPIWIN suite
Cornford, E. M., J. Membrane Biol. 64, 217-224 (1982)
Willhite CC (1986). Structure-activity relationships of|retinoids in developmental toxicology. II. Influence of the|polyene chain of the Vitamin A molecule, Toxicol. Appl.|Pharmacol. 83, 563-575
Method: other: Willhite (1986). Toxicol. Appl. Pharmacol. 83, 563-575
Kenaga E.E. and C.A.I. Goring, Relationship between water|solubility, soil sorption, octanol-water partitioning, and|concentration of chemicals in biota, ASTM STP 707, pp|78-115, 1980
BASF (1981) Zahn-Wellens test (mucochloric acid). BASF AG,|Dpt. of Ecology, 10.12.1981 (unpublished data; Reprint|05.07.2002)
Matsushima, Y. et al.: Subchronic Oral Toxicity Study of|Cyanoguanidine in F344 Rats, Eisei Shikensho Hokoku, 109,|61-66(1991)
Krul, C.A.M. 2002. Bacterial reverse mutation test with 2,2-dibutyl-1,3,2-dioxastannepin-4,7-dione (dibutyltin maleate). Report V4405/04. Department of Biomolecular Sciences, TNO Food and Nutrition Research, 3700 AJ Zeist, The Netherlands. 15 July 2002.
Scopas Technology Company (1984). Mutagenicity evaluation of|chlorine dioxide in the sister chromatid exchange assay in|vivo in mouse bone marrow. Litton Bionetics Inc, report n°=|22204.
Hoet, P., Buchet, P-J., Sempoux, C., Nomiyama, T., Rahier,|J. and Lison, D. Investigation on the liver toxicity of a|blend of HCFC-123 (2,2,-dichloro-1,1,1-trifluoroethane) and|HCFC-124 (2,chloro-1,1,1,2-tetrafluoroethane) in|guinea-pigs. Arch Toxicol, Vol 75, 274-283, 2001
Clarke, C.H. and Wade, M.J.: Mutat. Res. 28, 123-125|(1975);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Clariant GmbH (1997) EG-Sicherheitsdatenblatt Resorcin DS|(29.07.1997)
Hüls AG (1988). Daphnientest nach DIN 38412 Teil 11, Produkt Isophorondiisocyanat. Report No. D-310a (unpublished, 1 p).
Method: other: German Standard DIN 38412 part 11
Method: other: based on Draize, modified
Advanced Chemistry Development (2009) (ACD/Labs) Software Solaris V 4.67.
Bruno Bock Chemische Fabrik GmbH. (2000) Determination of|the boiling point
Syracuse Research Corporation calculated values SRC Report|1988
Bayer AG (2000). Investigation of the ecological properties of DESMODUR I. Bayer AG (Leverkusen) Report No. 860 A/99 with attachments (unpublished).
Salmonella typhimurium TA100, TA1535, TA98, TA1537, Escherichia coli WP2 uvr A
Craft et al., 1987, Formaldehyde mutagenesis and formation|of DNA-protein crosslinks in human lymphoblasts in vitro,|Mut. Res. 176, 147 - 155, No information
Genetic toxicity in vitro, IUC4#301/Ch.5.5
Weisburger, E.K. et al. (1978) J. Environ. Pathol. Toxicol.,|2, 325-356.
Method: other: According to the method described in Russfield, A. U. et al. (1975) Toxicol. Appl. Pharmacol., 31, 47-54
Stutz G, Petschel R (1991) FAT 65'023/N: Report on Melting|point / Melting range. Ciba-Geigy Ltd., CH-4002 Basel|(Switzerland); Test No. FC-90/30 T.
RTECS, Registry of toxic effects of chemical substances;|update 01/2001: Union Carbide Data Sheet, 11-03-71
Zieger J (1903) Studien ueber die Wirkung von Nitrobenzol,|Dinitrobenzol, Nitrotoluol, Dinitrotoluol von Lunge und Haut|aus. Dissertation, Wuerzburg 1903
Senczuk W and Rucinska H (1984). Toxicodynamic properties of|toluidines. Part V: Methaemoglobin-genic action of|toluidines. Bromat. Chem. Toksykol. 17, 241-243.
Method: other: single application by gavage, blood taken from heart or tail vein, immediately examination for methemoglobin according to the method of Evelyn-Malloy
Bus JS, Popp JA (1987) Perspectives on the mechanismof|action of the splenic toxicity of analine and|structurally-related compounds. Fd Chem Tox 25: 619-626
Lu B. et al (1982), Ecotox. Environ. Safety, 6, 19-27.
Method: other: glass-walled hexagonal chamber (5 m3, 1500l/min)
BASF Canada Inc. (1996). Material Safety Data Sheet provided|to Canadian Centre for Occupational Health and Safety, Issue|99-2, May 1999, date revised 15 Aug 1996.
Long-term toxicity to aquatic invertebrates, IUC4#10/Ch.4.5.2
Short-term toxicity to fish, IUC4#26/Ch.4.1
BASF AG, Product Safety, data assessment, SRC MPBPWIN v1.40,|25 Oct. 2002
Method: other: calculated via MPBPWIN v1.40
Bayer AG 2001e, Calculation with SRC-KowWIN v1.66 (2000)
Quillardet, P. et al.: Mutat. Res. 147 (3), 79-95 (1985);|cited in: RIFM database, location no. 15541
Genetic toxicity in vitro, IUC4#92/Ch.5.5
Niacinamide and Niacin, CIR report, scientific literature review, 2001
Method: other: comparable to OECD guideline 401
Probst GS, Hill LE, Thompson CZ (1982) The Identification if|Genotoxins in Urine of Chemically Treated Rats. Environ|Mutagen 4: 327-328
Genetic toxicity in vitro, IUC4#113/Ch.5.5
Method: other (calculated): Log Kow(version 1.65 estimate)
Odeigah P.G.C. (1997). Sperm head abnormalities and dominant|lethal effects of formaldehyde in albino rats. Mutation|Research 389, 141-148., No information
Alexander M and Lustigman BK (1966). Effect of chemical|structure on microbial degradation of substituted benzenes.|J. Agr. Food Chem. 14, 410-413.
Method: other: photometrical measurement of ring cleavage; method according to Alexander M & Aleem MIH (1961). J. Agr. Food Chem. 9, 44.
BASF (1985) Report on the study of Mucochlorsaeure techn.|rein (84/212) in the Ames test. BASF AG, Department of|Toxicology, 13.05.1985 (unpublished data)
Tanooka, H. Development and Applications of Bacillus subtilis Test Systems for Mutagens, involving DNA-Repair Deficiency and Suppressible Auxotrophic Mutations. Mutation Research. 42, 19-32, 1977
Merck-Schuchardt - Hohenbrunn, Germany. 2000. Safety Data Sheet. Dibutyltin dichloride for synthesis. 04.2000. The Merck Chemical Database - online. http://www.merck.de (accessed October 17, 2000).
Method: other: Federal Register 38, No. 187, p. 27019, § 1500.41
Salmonella typhimurium TA98, TA100, TA 1535, TA1537,|TA1538 and Escherichia coli WP2uvrA
Salmonella typhimurium: TA-1535, TA-1537, TA-98, |TA-100; Escherichia coli: WP2 uvr A
Method: other: NTP board EPA/FDA guidelines
Toxicity to microorganisms, IUC4#9/Ch.4.4
Ashby J, Tennant RW (1988). Chemical Structure, Salmonella|mutagenicity and extent of carcinogenicity as indicators of|genotoxic carcinogenesis among 222 chemicals tested in|rodents by the US NCI/NTP. Mut. Res. 204, 17-115.
Method: other: preincubation method according to Ames, Mutat. Res. 31,347(1975); Maron, Mutat. Res.113,173(1983), see also freetext TC
Hüls AG (1993b). Bestimmung der Auswirkungen von Vestamin|IPD auf das Wachstum von Scenedesmus subspicatus. Report No.|AW-266 (unpublished).
Back K.C. et al, Reclassification of materials listed as|tranportation Health hazard, Report No. TSA 20-72-3, Medical|Aerospace Research Laboratory (AFSCS), Wright-Patterson Air|Force Base, OHIO, Final Report, August 1972, At the request|of Department of Transporation , Washington, D.C., PB214-270
Method: other: observation time: 14 d (no further information)
Hüls AG (1985). Akute orale Toxizität von Laurinlactam für|Ratten. Report No. 0352 (unpublished)
Method: other: OECD Guideline 401 "Acute Oral Toxicity" (1981)
Method: other: SCE Test, BrdUrd-labelling technique
Genetic toxicity in vitro, IUC4#264/Ch.5.5
Repeated dose toxicity: inhalation, IUC4#98/Ch.5.4
Salmonella typhimurium strains TA 98, 100, 1535, 1537, 1538
Report No. EDI98002, Environment Agency, Japan (1999b):|unpublished report
FAO/WHO Techn. Rep. Ser. No. 539, (1974) Cited in United|States Environmental Protection Agency (1991)
Kommission Bewertung wassergefaehrdender Stoffe (KBwS), Datenblatt 785, Stoffname Benzoguanamin, vom 06.11.1991
Bazzon, M and Hervouet, G., (1989). Determination of Acute|Toxicity of HCFC 141b to Brachydanio. IRCHA Study B.7073,|IRICHA. Boite Postale No. l, 91710 Vert-le-Petit, France.
Method: other: ISO Standard 7346/1 (1984); OECD Method 203 4 April 1984 and EEC Directive 84/449, Method C1
Reinert K.H.: Regul. Toxicol. Pharmacol. 7, 384-389, (1987)
Koshi K and Fukuda K (1986) Cytogenetic and morphological|findings in rats exposed to benzotrichloride. Mutat Res 164:|272
Method: other: cytogenetic assay with peripheral blood lymphocytes after inhalation exposure of test animals
Air Products & Chemicals Inc., Allentown PA, USA|(1975) zitiert in HEDSET von Anchor Chemical (UK)|Ltd., 27.04.94
BASF AG (2003). Experimental Toxicology and Ecology, Neurotoxicity screening study, unpublished report, Project No. 31S0208/99147, 4 February 2003.
Rowe VK and Wolf MA (1962) in Patty FA (ed). Industrial|hygiene and toxicology, 2nd edition, 1722-1724 and|1763-1765.
Method: other: Acute Inhalation Toxicity; Whole body exposure
Bayer AG (1976). Leuschner F. Blankophor BA 200 %=PSG 125 %|Schleimhautvertraeglichkeit am Kaninchenauge bei einmaliger|Applikation. Study reported from Laboratorium für|Pharmakologie und Toxikologie to Bayer AG dated 1976-06-26.
Method: other: FDA, Washington 1965, HAZARDOUS SUBSTANCES Part 191, Section 11
Salmonella typhimurium TA 97, TA 100, TA 102, TA 104
Johannsen et al., Toxicol. Appl. Pharmacol. 41, 291-304 (1977)
Trenel, J. and Kuehn,R. (1982) Bewertung wassergefaehrdender|Stoffe im Hinblick auf Lagerung, Umschlag und Transport und|Untersuchung zur Abklaerung substanz- und|bewertungsmethodenspezifischer Grenzfaelle bei der Bewertung|wassergefaehrdender Stoffe, UFOPLAN des Bundesministers des|Innern im Auftrag des Umweltbundesamtes, Juli 1982.
Cotruvo, J.A. et al.: Ann. NY Acad. Sci. 298, 124-140|(1977);|cited in: RIFM database, location no. 3815
Genetic toxicity in vitro, IUC4#71/Ch.5.5
Hydrotox GmbH (2001b). Anaerobic Degradation of sodium|D-gluconate, according to DIN EN ISO 11734. Unpublished,|sponsored by Jungbunzlauer S.A., Marckolsheim,|France.
BASF AG, Department of Toxicology, unpublished results,|(I/71), 23 Oct. 1951
Long-term toxicity to aquatic invertebrates, IUC4#3/Ch.4.5.2
Carnegie-Mellon Institute of Research (1975). Silicone|A-187: 7-Day Rabbit Skin Inunction During 17|Calendar Days, Report 38-50, May 5, 1975.
Repeated dose toxicity: dermal, IUC4#4/Ch.5.4
Reported in Du Pont-Haskell Laboratory-Internal DMAC |Review, Oct. 1988 from Anon. (1979). Zhonghua Yufangyixue|Zazhi, 13: 29.
Thayer, P.S. and Kensler, C.J.: Toxicol. Appl. Pharmacol.|25, 169-179 (1973);|cited in: Anon.: Toxicology 79, 117 (1973)
Bengtsson, B.-E. (1978) Use of a harpacticoid copepod in|toxicity tests. Mar. Pollut. Bull., 9, 238-241.
Short-term toxicity to aquatic invertebrates, IUC4#100/Ch.4.2
Rippen, Handbuch Umweltchemikalien, 35. Erg. Lfg., 8/96, No information
Takahashi, O. (1992): Food Chem. Toxicol. 30, 89 - 97
Repeated dose toxicity: oral, IUC4#36/Ch.5.4
Patty`s Industrial Hygiene and Toxicology, Third Revised|Edition, Vol. 2C, pg. 4639 (1982), John Wiley and Sons
Hüls AG (1983b). Prüfung der akuten Augen- und|Schleimhautreizwirkung von Isophorondiamin. Report No. 0175|(unpublished).
Method: other: OECD Guideline 405 (1981)
McCann et al. (1975) Proceedings of the National Academy of Sciences USA 72:5135-5139.
Hohreiter D. W., Rigg D. K., Derivation of ambient water|quality criteria for formaldehyde, Chemosphere 45 (2001) 471|- 486, No information
Lide DR (1995). CRC Handbook of Chemistry and Physics 76th|ed. CRC Press Inc., 3-24.
Yasuo K, Fujimoto S, Katoh M, Kikuchi Y, Kada T (1978)|Mutagenicity of benzotrichloride and related compounds.|Mutat Res. 58: 143 - 150
Method: other: close to OECD guideline 471
Hüls AG investigation (unpublished) as cited in ECB IUDLID|2000.
Hüls AG (1975). Product information, Nov 1975, unpublished.
SafePharm Laboratories (2008) 3-Mercaptopropionic acid:|L5178Y TK +/- Mouse Lymphoma Assay. SPL Project Number|1158/0082.
Zhao, Yuan, Ji, Sheng (1997): chemosphere. 34 (8), 1837-1844
BASF AG, Sicherheitsdatenblatt Caprolactam Tabletten,|26.05.2000
Elf Aqutaine Production Research Laboratory (1995) VAPOR|PRESSURE CURVE JULY 1995
Raw Material Data Handbook, Vol.1.: Organic Solvents, p21,|1974
Bringmann,G., Kuehn,R., Zeitschrift fuer Wasser- und|Abwasser-Forschung, 15(1), 1-6, (1982)
Method: other: according to DIN 38412 part 11
Novartis Services AG (1997). Internal report No. N 061 13:|Determination of the inherent biodegradability of C.I.|Fluorescent Brightener 28/113 (22 % Na-salt):|Zahn-Wellens/EMPA-Test, OECD 302B, 1997-03-21.
Bishun, N. et al.: Mutat. Res. 26 (2), 151-155 (1974);|cited in: RIFM database, location no. 7110
S. typhimurium TA1535, TA100, TA1537, TA1538, TA98|S. cerevisiae D4
Casanova, M. et al.: Fund. Appl. Toxicol. 23, 525-536 (1994), No information
Genetic toxicity in vivo, IUC4#172/Ch.5.6
CIBA-GEIGY (1996). Internal report No. N 084 14: Acute|toxicity of C.I. Fluorescent Brightener 28/113 (90 %|Na-salt) to Daphnia magna. Ciba-Geigy Ltd., Product Ecology,|Basel, CH, 1996-10-16.
Sharp, D.W., The sensitization potential of some perfume|ingredients tested using a modified Draize procedure,|Toxicology, 9, 262-271, 1978
Method: other: modified Draize (1959) technique
Pickering Q.H. et al (1966), J. Water Pollut. Control Fed.,|38(9), 1419-29.
Method: T31-18:Chemical Substances Control Law of Japan and OECD Test Guideline 473
Hoechst AG (1982) Internal Study W 82-084:|- Biodegradability according to Respirometer test.|- Acute toxicity to Daphnia magna
Method: other: Static test in open system
Bates, H.K., McKee, R.H., Bieler, G.S., Gardiner, T.H., Gill, M.W., Strother, D.E., and Masten, L.W.
Developmental toxicity / teratogenicity.003
Hanstveit, R. Trichlorooctylstannane (CAS# 3091-25-6): Determination of the ready biodegradability in a Manometric Respiration Test. TNO Report No. V2496/01. July 2003.
Schroeder HA and Mitchener M (1975). Life-term effects of|mercury, methyl mercury, and nine other trace metals on|mice. J. Nutr. 105, 452-458.
Monsanto Co (1981a) 90-day study of p-Nitrochlorobenzene|administered to male and female rats via gavage. ML-79-014,|EPA-OTS0538501 and EPA-OTS0557084
Method: other: according to OECD Guide-line 408, see also freetext ME
Dilling et al.. (1976) Env Sci Res 10, 351-356.
Akzo Chemicals BV (1989) Toxicity of methyl ethyl ketone|peroxide for activated sludge. Study/Project#: CRL F891120;|Project T89-6-1.9. Study Date: 11/30/89.
Method: OECD Guide-line 209 (Activated Sludge, Respiration Inhibition Test)
Toxicity to soil microorganisms, IUC4#1/Ch.4.4
Ide, F. et al.: J. Cancer Res. Clin. Oncol. 102 (2), 115-126|(1981);|cited in: RIFM database, location no. 12008
Smyth HF, Carpenter CP, Weil CS (1951) Range-finding|toxicity data: list IV. Arch Ind Hyg Occup Med 4: 119 - 122
Method: other: according to Smyth HF and Carpenter CP J Ind Hyg Toxicol: 30, 63-68 (1948)
Hoffmann-LaRoche, Acute toxicity, eye and skin irritation|test of fragrance materials, unpublished results, 1967 cited|in RIFM-FEMA data base, Oct. 2002
Dow Corning Corporation (1966)TOXICOLOGICAL PROPERTIES OF|HEXAMETHYLDISILAZANE (Z-6080, LOT 6); 1/12/66; EPA DOC. NO.|86940001071; FICHE NO. OTS0556525; SUBMITTED BY INDUSTRY,|MODIFIED. Cited in NISC and BiblioLine (2009) BiblioLine - |www.nisc.com
BASF AG (1977). Department of Ecology. 2nd VCI ringtest|1976/77 (unpublished).
Hayashi M et al.: Fd. Chem. Toxic., 26, 487-500, (1988)
Monsanto Study No. ML-82-253 as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Method: other: Monsanto Laboratory method
Repeated dose toxicity: oral, IUC4#40/Ch.5.4
Method: other: 0.1 ml/eye/rabbit, into the cupped conjunctival sac
JETOC Newsletter (1985) Jetoc Newsletter No. 4: 14-20: cited|in GDCh (1988) m-Chlornitrobenzol/p-Chlornitrobenzol.|BUA-Stoffbericht: 11
Atkinson,R. et al., Atmospheric Environment 26A(7),|1187-1230, 1992, No information
EPIWINNT Version 3.10, 2000 U.S. Environmental Protection Agency (April, 2001)
Edney, D. and Driscoll, D.J., Chlorine initiated|photooxidation studies of hydrochlorofluorocarbons (HCFCs)|and hydrofluorocarbons (HFCs): Results for HCFC-22, HFC-41,|HCFC-124, HFC-125, HFC-134a, HCFC-142b and HFC-152a, J.|Atmos. Chem., 24, 1067-1081, 1992
Yoshioka Y, Ose Y and Sato T (1985). Testing for the|toxicity of chemicals with Tetrahymena pyriformis. Sci.|Total Environ. 43, 149-157.
Short-term toxicity to fish, IUC4#68/Ch.4.1
Forbis, AD. Acute Toxicity of Butyl Acrylate to Selenastrum|Capricornitum Printz. Testing Facility: Analytical|Bio-Chemistry Laboratories, Inc., Columbia, MO. Project|Identification No. 37341. Study Date: 1990.
Method: other: OECD Guide-line 201 (Algae, Growth Inhibition Test), results given as nominal concentration
CIIT (1982). CIIT Docket 10992. Teratological and postnatal|evaluation of dinitrotoluene in Fischer 344 rats. Chemical|Industry Institute of Toxicology, Research Triangle Park,|USA, NTIS OTS 221.
Graf, U. et al.: Environ. Mol. Mutagen. 16, 255-237 (1990), No information
Method: other: Wing SMART = Wing Somatic Mutation and Recombination Test
Szabad, J. et al.: Mutat. Res. 113, 117-133 (1983), No information
Genetic toxicity in vivo, IUC4#19/Ch.5.6
Kanwar, Nanda (1986) Biologia Plantarum (praha) 28(3):202-206.
Zeiger, E., Anderson, B. et al., Environ. Mutagen., 9|(Suppl. 9), 1-110 (1987)
Method: other: as described by Haworth et al.: Environ. Mutagen. 6 [Suppl. 1] 3-142, (1983)
Hazelton Laboratories, Inc. (1966) Acute Oral Administration|- Rats; Primary Skin Irritation - Rabbits; Acute Eye Irritation|- Rabbits - Methyltrimethoxysilane, Triethoxysilane, Trimethoxysilane, Tetramethoxysilane. Final|Report. Project No. 349-128. April 19, 1966.
Lang, Ma, Lu, Wang, Bian (1996) Chemosphere. 32(8),|1547-1552
McFarlane, M. et al. (1997): Food Chem. Toxicol. 35,|753-767
Toxicity to reproduction, IUC4#9/Ch.5.8.1
BASF, A.G. (1989) Unpublished study No. 78/650, 21.05.1980.|In European Commission. 1996. Acetic acid. International|Uniform Chemical Information Database; cited in American|Chemistry Council's Acetic Acid and Salts Panel (2003) U.S.|HIGH PRODUCTION VOLUME (HPV) CHEMICAL CHALLENGE PROGRAM -|ROBUST SUMMARIES for CARBOXYLIC FOOD ACIDS AND SALTS|CATEGORY. April 16, 2003.
Salmonella typhimurium TA 1535, TA 100, TA 1537, TA 98
Hommel G (ed.) (2001). Handbuch der gefährlichen Güter|(Handbook of Dangerous Goods), 2001. Springer-Verlag Berlin|Heidelberg, data sheet No. 1330.
BASF AG (1994) Department of Toxicology. Study on the acute|inhalation toxicity LC50 of Neodecansäurechlorid as a vapor|in rats 4-hour exposure. Project No. 13I0379/927015.|Unpublished study report dated Feb 9, 1994.
Chow ST and Ng TL (1983). The Biodegradation of|N-Methyl-2-Pyrrolidone in water by sewage bacteria. Water|Res. 17, 117-118.
Method: other: Semi-continuous Activated Sludge Test according to ASTM (Method D2667-70, 1975)
Biodegradation in water: screening tests, IUC4#23/Ch.3.5
LISEC (1999). Biodegradation Study of|5-Ethylidene-2-Norbornene -Headspace CO2 Evolution Test.|Report No. WB-13-013. LISEC, Craenevenne, Genk, Belgium.
Method: other: ISO/TC 147/SC 5/WG 4 N 182 (1995)
Ichikawa, H. et al. (1976): Ann. Rep. Tokyo Metr. Res. Lab.|Public Hlth. 27, 93 - 99
Documentation of the Threshold Limit Values for Substances|in Workroom Air, supplements. (1982).
Falcone JS (1997). Silicon compounds - Synthetic inorganic|silicates. In: Kirk-Othmer Encyclopedia of Chemical|Technology, 4th ed. Wiley, New York, USA. 22, 1-30.
Koopman, T.S.M. and Pot, T.E. (1986) Primary irritation|study of calcium chloride dihydrate to the eye of the male|rabbit. Duphar Report No. 56645/43/86.
Monsanto Chemical Co. (1976) Teratogenicity study in albino|rabbits with Santoflex 13. Study report BTL-76-146 of|Monsanto Chemical Co. NTIS/OTS 0524068, EPA/OTS document #|88-900000138 (1990)
Industrial Hygiene and Toxicology. 1989. F. Patty (ed.). 2nd ed. Volume II: Toxicology. Interscience Publishers. New York, NY. P. 1866.
Collett, A.R. and J. Johnston (1926)|Solubility relations of isomeric organic compounds VI.|Solubility of the nitroanilines in various liquids.|J Phys. Chem. 30, 70-82.
Schering AG. 1992. The temperature dependence of the vapour pressure of ZK 22663. Study No. 91/178. Report Nr. APC 18/92. 06.03.1992.
Gelbke, HP (1983) Personal communication on basis of studies by BASF AG, Ludwigshafen, 1978-1983.
CERI (1995) Chemicals Evaluation and Research Institute|(Kurume, Japan) Test No. 51203A
Landry TD et al. (1983) Fund Appl Toxicol , 3, 627-630.
Nalbandyan TI, Gizhlaryan MS (1985). Effect of 1,4-dichloro-2-butene and 3,4-dichloro-1-butene on chromosomes of albino rats. Zh. Eksp. Klin. Med. 25, 335-339.
Journal of the American College of Toxicology (1990), Part B, Vol 1, p 104-105.
Berufsgenossenschaft der chemischen Industrie, Primary Eye|Irritation Study With Triethylenediamine in Rabbits, APCI|RRRS EXT-03/013, 11 Feb 1987
Baudouin, M.F. and Scoppa, P. (1974) Acute toxicity of|various metals to freshwater zooplankton. Bull. Env. Contam.|Toxicol., 12(6), 745-751.
Herve-Bazin B, Gradiski D, Duprat P, Marignac B, Foussereau|J, Chevalier C, Bieber P (1977) Occupational eczema from|N-isopropyl-N' phenylparaphenylenediamine (IPPD) and|N-dimethyl-1,3 butyl-N'-phenylparaphenylenediamine (DMPPD)|in tyres. Contact Dermatitis 3: 1-15
Method: other: according to Magnusson & Kligman (1969)
APCI, 1,4-Diazabicyclo[2.2.2]Octane: Determination of the|Hydrolysis as a Function of pH (OECD 111), unpublished|study, APCI RRRS EXT-99/102, 7 Jan 2000
Kunze, E. et al.: Urol. Int. 42, 108-114 (1987);|cited in: RIFM database, location no. 7124
Shell Research Limited 1982, Butylated hydroxy toluene:|Acute toxicity to Salmo gairdneri, Daphnia magna, and|Selenastrum capricornutum; Document Number: SBGR.82.157
Method: other: acc. to Miller & Green (1978): The Selenastrum capricornutum (Prinz) algal assay bottle test. EPA-60/9-78-018
de Zwart, D. and Slooff, W. (1987) Bull. Environ. Toxicol. 38, 345-351
Salmonella tester strains TA98, TA100, TA1535, TA1537 and TA15|38
Yen J-H, Lin K-H, Wang Y-S (2002) Acute lethal toxicity of|environmental pollutants to aquatic organisms. Ecotoxicol|Environ Safety 52: 113 - 116
Short-term toxicity to fish, IUC4#27/Ch.4.1
Bayer AG 1986e, Internal study: Toxicity to Leuciscus idus|(1986)
Simmons, D.M. et al.: Environ. Mutagen. 8, 78 (1986);|abstract no. 210, No information
BUA (1991). Chemical Report No. 81, August 1991: Formic|Acid. Edited by Beratergremium für umweltrelevante Altstoffe|(BUA) der Gesellschaft Deutscher Chemiker. VCH Publishers,|Weinheim, Germany.
Method: other: Hungate serum bottle technique
Method: other: according Hollstein et al., 1979
Genetic toxicity in vitro, IUC4#72/Ch.5.5
Ciba-Geigy Ltd. 1974. Acute Dermal LD50 of TK-11692 in the Rat. Project No.: Siss 3985. 7.5.1974.
Method: other: not reported (OECD 402 compliant)
Genetic toxicity in vitro, IUC4#98/Ch.5.5
Shelby et al.: Environm. Molec. Mutagenesis 21, 160-179,|(1993)
Short-term toxicity to fish, IUC4#40/Ch.4.1
Meier JR, Ringhand HP, Coleman WE, Schenck KM, Munch JW,|Streicher RP, Kaylor WH, Kopfler FC (1986) Mutagenic|by-products from chlorination of humic acid. Environ Health|Persp 69: 101-107
Method: other: according to Maron and Ames: Mut. Res., 113, 173-215 (1983)
Hallas, Alexander (1983): Appl. Environ. Microbiol. 45, |1234-1241
Biodegradation in water: screening tests, IUC4#53/Ch.3.5
Kozuka T et al. (1980): Pigmented contact dermatitis from|azo dyes. Contact Dermatitis 6, 330-336
Ishidate, M., Jr. et al., Food Chem. Toxicol. 22, 623-636|(1984)
Harris JC (1990). Rate of Hydrolysis. In: Lyman WJ, Reehl WF, Rosenblatt DH (eds.) Handbook of Chemical Property Estimation Methods. American Chemical Society, part 7.
Donlon, Razo-Flores, Field, Lettinga (1995): Appl. Environ.|Microbiol. 61(11), 3889-3893
Method: other: methane production measurement by gas chromatography
Toxicity to microorganisms, IUC4#21/Ch.4.4
Kato, H.: Exp. Cell Res. 88 (2), 239-247 (1974);|cited in: RIFM database, location no. 7198
Pollard, I. et al.: J. Develop. Physiol. 13, 59-65 (1990)
Developmental toxicity / teratogenicity, IUC4#15/Ch.5.8.2
BASF (1995): Acute toxicity study on the zebra fish|(Brachydanio rerio HAM. and BUCK.) of Potassium|metabisulfite in a static system. BASF AG, Department of|Toxicology, Proj. No. 17F0167/925041, Aug 01, 1995
Krul, C.A.M. 2003. Tetrabutylstannane [CAS# 1461-25-2]: Micronucleus test in bone marrow cells of mice. Report V4404/04. Department of Biomolecular Sciences, TNO Chemistry, 3700AJ Zeist, the Netherlands. 2 April 2003.
Basch et al. (1971) Chlorinated municipal waste toxicities|to rainbow trout and fathead minnows. Water Pollut. control|Res. Ser., EPA-18050-GZZ-10/71, Res. and Monit., US EPA, US|NTIS, PB-209 890, 53 p.
Short-term toxicity to fish, IUC4#32/Ch.4.1
Van den Heuvel et al. (1990) Food Chem. Toxic. 28:469-482.
Qatibi A-I., Bories A. & Garcia J-L., Sulfate reduction and|anaerobic glycerol degradation by a mixed microbial culture,|Curr. Microbiol. 22: 47-52, 1991 (105)
CERI. (2004) Measurement of partition co-efficient of p-toluic acid. Unpublished data.
Method: other: dose finding study for cancerogenesis bioassay
Timson, J.: Mutat. Res. 15 (2), 197-201 (1972);|cited in: RIFM database, location no. 7196
Genetic toxicity in vitro, IUC4#96/Ch.5.5
Method: other: ORIGINAL-MITI-Test, Biodegradability and Bioaccumulation Test of Chemical Substances (C-5/98/JAP) 1978
BASF AG, 2003, Product Safety, SRC BCFWIN V2.14, data|assessment, unpublished calculation, 4 Dec. 2003.
Method: other: calculated using SRC BCFWIN v2.14
Shell Research Group Report (1984). Report # SGBR.84.032,|Sittingbourne Research Centre, Sittingbourne, Kent, England.
Dawson, G.W. et al., Journal of Hazardous Materials 1,|303-318 (1975/77)
McLeese et al. (1979): Chemosphere 8, 53-57
Laughton PM and Robertson RE (1959). Solvolysis in hydrogen|and deuterium oxide. Can. J. Chem. 37, 1491-1497.
Method: other: hydrolysis in light and heavy water
Boublík, T. et al., Physical sciences data 17, Elsevier,|1984, No information
Abernethy DJ and Couch DB (1982). Cytotoxicity and|mutagenicity of dinitrotoluenes in Chinese Hamster ovary|cells. Mutat. Res. 103, 53-59.
Method: other: according to O'Neill J.P. et al., Mutat. Res. 45, 91 (1977)
TKL Research, Inc., Study No. 9471; TKL Study No. DS105100;|Dow Corning Corporation internal report no.|2001-I0000-49736, 2001.
Safepharm Laboratories Ltd. (1993). Study conducted for|Berol Nobel AB, project No. 142/123, 19 Mar 1993,|unpublished report.
BASF AG, Department of Ecology, unpublished study, Determination of the acute effect of Isobutyl acrylate on the swimming ability of the water flea Daphnia magna STRAUS, |1/90/1929/50/1. January 1991
Method: other: Directive 79/831/EEC, annex 5, C
Escherichia coli PQ37 (uvrA-) and GC4415 (uvrA-)
Alexander M, Lustigman BK. (1966) Effect of chemical|structure on microbial degradation of substituted benzenes.|J Agric Food Chem 14, 410-3
Biodegradation in water: screening tests, IUC4#18/Ch.3.5
Hoechst AG (1989) Nitro-o-dichlor-benzol. Chromosome|aberrations in vitro in V79 Chinese hamster cells|(unpublished report no 89.0815). Hoechst AG, Frankfurt
BASF AG. 1989. Hauptprufung fur Journal Nr 09950, prufung auf okotoxizitat: Hemmung der Algen-Zellvermehrung nach DIN 38412 L 9, butylglycolacetat, dated 18.09.1989. [Main test for study for ecotoxicity; algal cell reproduction inhibition according to DIN 38412 L 9, butylglycolacetate.
Method: other: Scenedesmus-cell reproduction inhibition test DIN 38412 L 9
AUTHOR (1980) Archives of Toxicology Vol. 43:249 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com)
Hommel G (1998). Handbuch der gefährlichen Güter, 5th Ed.|1998, Springer-Verlag (Berlin), Merkblatt 783.
Voogd, C.E. and van der Vet, P.: Experientia 25, 85-86|(1969);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Genetic toxicity in vitro, IUC4#29/Ch.5.5
BASF (1999) Safety data sheet Mucochlorsaeure techn. rein,|06.01.1999, BASF AG
Melting point/freezing point, IUC4#50/Ch.2.1
BASF AG (2007). Physico-chemical properties of|"Ameisensäure 85%". BASF AG, GKA Competence Center|Analytics, Ludwigshafen/Rhein, Germany, Study No. 07L00172,|31 Jul 2007 (unpublished).
Albanese V, Milano JC, Vernet JL (1987). Etude de l'evaporation de quelques hydrocarbures halogenenes de faible masse moleculaire dissous a l'etat de traces dans l'eau. Environ. Technol. Lett. 8, 657-668.
Method: other (measured): see test conditions
Marion CV and Malaney (1963). The oxidation of aliphatic|compounds by Alcaligenes faecalis. J. Water Pollut. Contr.|Fed. 35, 1269-1284.
Davydova SG (1967) A comparison of the properties of|nitrochlorobenzene isomers for the determination of their|permissible concentrations in water bodies. Hyg Sanit 32(8):|161-166
Lide DR (1991). Handbook of Chemistry and Physics. CRC|Press, Boston, 72nd Edition, 4-109.
Plesner, H.B. and Hansen, K.H.: Carcinogenesis 4, 457-459|(1983), No information
Van den Heuvel, M.J., D.G Clark, R.J. Fielder, P.P. Koundakjian, G.J.A.Oliver, D.Pelling, N.J.TomLinson, A.P,Walker. The International validation of a fixed-dose procedure as an alternative to the classical LD50 test. Food Chem. Tox. 28(7), 469-482, 1990
Back KC, Thomas AA, MacEwen JD (1972) Reclassification of|materials listed as transportation health hazards. Final|Report: Report No. TSA-20-72-3, Aerospace Medical Research|Laboratory Aug/1972
Bruner, L.B. (1959) Dow Corning Corporation, Report No.|1959-I0030-1794.
Chemicals Evaluation and Research Institute (2004). Melting|Point of 4-ethylmorpholine. Report Number 805288.
He Z, Spain JC (2000) Reactions Involved in the Lower|Pathway for Degradation of 4-Nitrotoluene by Mycobacterium|Strain HL 4-NT-1. Appl Environ Microbiol 66 (7): 3010 - 3015
Cronin MTD, Zhao YH, and Yu RL (2000). pH-dependence and|QSAR analysis of the toxicity of phenols and anilines to|Daphnia magna. Environ. Tox. 15(2), 140-148.
Method: other: according to a Dutch national standard method: NEN 6506, 1979 (Water-Bepaling van de toxiciteit met behulp van algen)
Toxicity to aquatic algae and cyanobacteria, IUC4#7/Ch.4.3
OECD Guideline 421 (Reproduction / Developmental Toxicity Screening Test)
Nagorny et al.: Gig. Truda Profzabol. 7, 27-30 (1979);|(tranlated from Russian), No information
Thomulka,K. et al., J. Environ. Sci. and Health A28,|2153-2166, 1993, No information
Method: other: Bioluminescent Direct Assay
Hohensee F., Faserforschung und Textiltechnik 8, 299-303,|(1951)
Meylan W. and Howard P. 1999. EPIWin Modeling Program.| Syracuse Research Corporation. Environmental Science|Center,| 6225 Running Ridge Road, North Syracuse, NY 13212-2510
Method: other: (calculated) MPBPWIN (v1.31) Program ; Adapted Stein and Brown Method
West RC. (1969) CRC Handbook of Chemistry and Physics 50th|Edn CRC Press Inc. Cleveland Ohio
Genetic toxicity in vivo, IUC4#15/Ch.5.6
Vorlaeufige Ergebnisse des F + E-Vorhabens "Bewertung|wassergefaehrdender Stoffe", zit. in: Datenblaetter zum|Katalog wassergefaehrdender Stoffe, KBwS, Nr.80, (1985)
US DHEW, US Department of Health, Education and Welfare, Washington DC, (1978); cited in WHO: Environmental Health Criteria 65, WHO, Geneva, pp. 93 ff., (1987) cited in IUCLID (2000).
Hicks SL. 2002. Toxicity of 2-Ethylhexyl Acetate to the |Unicellular Green Alga, Selenastrum capricornutum. Report #46957 prepared by ABC Laboratories Inc., Columbia Missouri. May 01, 2002
Bayer AG (2002) p-Nitrotoluol eingegossen,|reproduction/developmental toxicity screening test in rats|after oral administration. Report No At0021, Sept/17/2002
Method: other: in compliance with OECD 421, additional evaluation: liver, spleen, kidney, pituitary gland, uterus, uterine cervix and vagina, mammary gland, seminal vesicle and prostate
Bandman A.L. et al., (1994) Hazardous substances. Galogen|and oxygen containing substances), Chimia 1994. -:529, 1994
BASF AG, Analytical department, unpublished report, J.Nr. PH|6764
Goodwin, B.F.J. et al.: Contact Dermatitis 7, 248-258 (1981), No information
Fostel, J., Allen, P.F., Bermudez, E., Kligerman, A.D.,|Wilmer, J.L., and Skopek, T.R.: Mutat. Res. 155:75-81|(1985).
CIIT (1982) CIIT Docket 12362, 104 week toxicology study in|rats,|dinitrotoluene, final report, Chemical Industry Institute of|Toxicology, Research Triangle Park, USA
SKW Trostberg Aktiengesellschaft, Firmenprospekt ueber|Dicyandiamid (1985)
Hüls AG (1991). Determination of the mutagenicity of lauryl|lactam. Report No. AM-91/6 (unpublished)
EU Method B.13/14 (Mutagenicity - Reverse Mutation Test Using Bacteria)
Pliss GB (1958). The carcinogenic activity of|dicyclohexylamine and its nitrite salt. Vopr. Onkol. 3,|659-668.
BASF AG, Department of Toxicology; Study of|3-methylbuten-2-ol-1 in the Ames test (standard plate test|and preincubation test with Salmonella typhimurium),|unpublished report (88/360), project no. 40M0360/884306, 24|Feb. 1989
Kobayashi, T. et al., Water Sci. Technol. 21, 55-65 (1989)
Method: other: anaerobic degradation, static, 37 degree C, analytical control ofconcentration, pH 6.7-6.9
Cannon Laboratories Inc. (1974) The acute LC50 inhalation study of vicinal mix in rats. Reading PA. Report No. 4E-4015 and 4E-4022. Air Products and Chemicals Inc.
Masalitinova TN, Oleinikova TP, Ryadnenko VL, Kiseleva NN,|Lebedeva ND (1982) Thermal Effects of the Hydrogenation of|Chloronitrobenzenes. J Appl Chem USSR (Engl. Transl.) 54|(8): 1551 - 1554
Bayer AG (1990). Internal study: Toxicity to Bacteria of|Dicyclohexylamine (Study No. 90111907).
Hoechst AG (1995): EG-Sicherheitsdatenblatt beta-Naphthol DS|(19.12.1995)
Ames, B.N., J. McCann, and E. Yamasaki. 1975. Mutation Research. 31:347-364.
Method: other: equivalent to MET/MHLW/MAAF guidelines (Japan); OECD Guide-line 471; Directive 2000/32/EC, method B13/14; and U.S. EPA TSCA/OPPTS harmonized guidelines
Chinese hamster ovary cells (XRCC1-proficient and -deficient)
Genetic toxicity in vivo, IUC4#35/Ch.5.6
Method: other: Methods for Acute Toxicity with Fish, Macroinvertebrates and Amphibians EPA-600/3-75-009 (1975)
Isogai et al. 1972. SCI PAP COLL GEN EDUC, UNIV TOKYO 22|(2): 129
Fernandez M, Gauthier L, Jaylet A (1989) Use a newt larvae|for in vivo genotoxicity testing of water. Mutagen 4: 17-26
BASF AG, 1989, Analytical Laboratory, Bestimmung der|Löslichkeit der Prüfsubstanz in Wasser bei 25°C, unpublished|study, 106288/13, 02 May 1989
Yoshioka, Y. et al., Ecotox. Environ. Saf. 12 (3), 206-212|(1986)
Gusten, H., Klasinc, L., and Maric, D. J. : Atmos. Chem.|2:83-94 (1984).
Moje W.; Martin J.P.; Baines R.C.: Structural effects of|some organic compounds on soil organisms and citrus|seedlings grown in an old citrus soil. J. Agric. Food Chem.|5, 32-6 (1957)
MOE, Japan (1996) Ministry of Environment: unpublished report of acuite toxicity study of N-tert-butyl-2-benzothiazonylsulphenamide to Medaka (Oryzias latipes).
Degussa-Huls AG #: 88-0299-FGM Study to determine the|ability of nineteen compounds to induce mutation in three|Histidine-requiring strains of Salmonella typhimurium.
Miller RG, Kopfler FC, Condie LW, Pereira MA, Meier JR, Ringhand HP, Robinson M and Casto BC (1986). Results of toxicological testing of Jefferson Parish pilot plant samples. Environmental Health Perspectives, 69, 129-139.
Method: other: "rec-assay" according to Kada T, Tutikawa K, Sadaie Y (1972) In vitro host-mediated "rec-assay" procedures for screening chemical mutagens; and phloxine, a mutagenic red dye detected. Mutat Res 16: 165 - 174
Kloepffer, W. and Daniel, B.: full reference not available|(1990).
Method: other (calculated): APOWIN (ver.1.55), Syracuse Research
Acute toxicity: inhalation, IUC4#13/Ch.5.1.2
Kanabur, Banu Sangli (2000) Geobios 27:188-190.
Griese M, Winzinger G, Schams A, Josten M, Ziesenis A, Maier|K (1999) Health effects of sulfur-related environmental air|pollution: the pulmonary surfactant system is not disturbed|by exposure to acidic sulfate and neutral sulfite aerosols.|J Aerosol Med 12: 37-44
Honma M. et al. (1999). Evaluation of the mouse lymphoma tk|assay (microwell method) as an alternative to the in vitro|chromosomal aberration test. Mutagenesis, 14(1), 5-22.
Hulzebos EM, Adema DMM, Dirves-van Breemen EM, Henzen L, van|Dis WA, Herbold HA, Hoekstr JA, Baerselman R, van Gestel CAM|(1993) Phytotoxicity Studies with Lactuca sativa in Soil and|Nutrient Solution. Environ Toxicol Chem 12: 1079 - 1094
Tsuchimoto T. and Matter B.E.: Arch. Toxicol 42, 239-248,|(1979)
Method: other: According Schmid 1975; Tsuchimoto and Matter 1977
Takamutsu M. et al. (1998). Test on the degree of|bioaccumulation of CG31-1017 in carp, Cyprinus carpio, |Institute of Ecotoxicology Gakushuin University, September|30, 1998
IRDC (1976) Acute Oral Toxicity in Male Albino Rats.|International Research and Development Corporation (IRDC).|Study #: 378-001. Study Date: July 15, 1976.
Method: other: Similar to a guideline study
Hallas L, Alexander M (1983) Microbial Transformation of|Nitroaromatic Compounds in Sewage Effluent. Appl Environ|Microbiol 45 (4): 1234 - 1241
Bayer Industry Services (2004a). 4,4´-bis|[(4-Anilino-6-bis(2-hydroxyethyl)amino-s-triazin-2-yl)amino]|2,2´-stilbenedisulfonic acid, K/Na-salt (CAS 70942-01-7).|Calculation of|- Log Octanol-Water Partition Coefficient with KOWWIN v.1.67|(2000)|- Indirect Photodegradation with AOPWIN v.1.91 (2000)|- Bioconcentration factor with BCFWIN v.2.15 (2000)|- Soil Adsorption coefficient with PCKOCWIN v.1.66 (2000).
Klimmer, O.R. von. 1969. Die anwendung von Organozinn-Verbindungen in experimentell-toxikologischer Sicht. Arzneimittel-Forsch. 19:634-638.
Schulz KH and Wulf K (1957) Klinische und experimentelle|Untersuchungen zur Frage der Vertraeglichkeit optischer|Aufheller fuer die Haut. Arzneimittelforschung 7: 402 - 404
BASF AG, 2003, Department of Product Safety, unpublished|calculation, SRC WSKOW v1.40, 25 June 2003
Method: other: calculated via WSKOW v1.40
Ministry of Environment (MOE), Korea(2001), Combined Repeated Dose Toxicity with the Reproduction /Developmental Toxicity Screening Testing of Acetanilide in Rats(test No.G00154, tested by KRICT)
Kawane, H. (1996), Menthol and aspirin-induced asthma,|Respir. Med. 90, 247
Hermens J, Leeuwangh P, and Musch A (1984). Quantitative|structure-activity relationships and mixture toxicity|studies of chloro- and alkalylanilines at an acute lethal|toxicity level to the guppy (Poecilia reticulata).|Ecotoxicol. Environ. Safety 8, 388-394.
NOTOX (1995). Daphnia magna, Reproduction Test with TK 10027|(Meti-lox). NOTOX B.V., 's-Hertogenbosch, The Netherlands.|Unpublished re-port # 128767. April 11, 1995.
Degussa AG, unpublished report, 1985, Hautreizung Kaninchen. Degussa Report No. 85-0071-DKT
Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538; Escherichia coli WP2uvrA
O'Neill MJ (2001) in The Merck Index An Encyclopedia of Chemicals, Drugs and Biologicals, 13th ed., Merck & Co., Inc., Whitehouse Station, NJ, p. 146.
CIT (1995) Reverse Mutation Assay on Bacterial Salmonella typhimurium with isooctyl thioglycolate. CIT report no. 12571 MMO, 19th July 1995.
Garry, V.F., Nelson, R.L., Griffith, J., Harkins, M., 1990.|Preparation for human study of pesticide applicators: Sister|chromatid exchanges and chromosome aberrations in cultured|human lymphocytes exposed to selected fumigants, Teratog.|Carcinog. Mutag. 10:21-29.
Method: other: Exposure in aqueous solution
Sperling, F. and Ewenike, H.K.U. (1972), Changes in Ld50 of|Parathion and Heptachlor Following Turpentine Pretreatment,|Environmental Research 5, 164-171
Repeated dose toxicity: oral, IUC4#11/Ch.5.4
Van Duuren BL, Goldschmidt BM (1976) Co-carcinogenic and tumor-promoting agents in tobacco carcinogenesis. Journal of the National Cancer Institute 56(6):1237-1242.
Stankowski, L.F.: Salmonella-Escheria coli/|mammalian-microsome reverse mutation assay with a|confirmatory assay with 2,2'-thiodiethanol. Covance Study|No. 22283-0-409OECD, Covance Laboratories Inc., Vienna, VA|(2001); submitted to U.S. Army Center for Health Promotion|and Preventive Medicine, Aberdeen Proving Ground, MD;
Method: other: OECD Guide-line 471, 1997
Hirose M, Yamaguchi S, Fukushima S, Hasegawa R, Takahashi S, Ito N (1989) Promotion of dihydroxybenzene derivatives of N-methyl-N-nitro-N-nitrosoguanidine-induced F344 rat forestomach and glandular stomach carcinogenesis. Cancer Research 49:6015-6018.
Method: other: Two-stage carconogenesis study
Cairns J. Jr et al. (1976): Invertebrate response to thermal|shock following exposure to acutely sub-lethal|concentrations of chemicals. Arch. Hydrobiol., 77(2),|164-175
Yoshioka Y, Nagase H, Ose Yand Sato T (1986). Evaluation of|the test method "Activated sludge, respiration inhibition|test" proposed by the OECD, Ecotoxicol. Environ. Safety 12,|206-212.
Method: other: OECD Guideline 209 "Activated Sludge, Respiration Inhibition Test", Draft 1.8.83
BASF AG (2003). Agricultural Center Limburgerhof, Octanol/Water Partition Coefficient, unpublished data, study code 71995_2, BASF DocID 2003/1021971, 16 December 2003.
Method: other (measured): OECD Draft Guideline (September 2002) "Partition Coefficient (n-octanol/water): Slow-Stirring Method"
Bomhard E and Löser E. Blankophor MBBH (Natrium Salz):|Chronische toxikologische Untersuchungen an Ratten. Report|No. 7234, January19, 1978. Institute of Toxicology, Bayer|AG, Wuppertal, Germany.
Method: other: internal method Bayer chronic toxicity/carcinogenicity
Hawley's Condensed Chemical Dictionary (1977). 9th ed.
Grant, W.M. (1962). Toxicology of the eye. Charles C. Thomas|Springfield, IL
S. typhimurium LT-2 (hisC117, hisG46, TA1530, hisD3052, TA1531, TA1532)
BASF AG, 2003, Calculation of recovery rates of 100 mg and|200 mg 6-methylhept-5-en-2-one from its volatility in an|algae, daphnia and fish test, data assessment, 07 July 2003
Method: other: algal growth inhibition test according to DIN 38412/9
Smyth, H.F. et al., (1962) Range-finding toxicity data List VI. Am Ind Hyg Assoc J, 23:95-107.
BASF (2001) Prenatal developmental toxicity study in|Sprague-Dawley rats after oral administration, Report No.:|30R0345/999062. BASF AG, Product Safety, 12.11.2001|(unpublished data)
Hoechst AG, EG-Sicherheitsdatenblatt Acetanilide, 26, 01, 1994
Method: other: National Environmental Research Center (1974): Methods for Acute Toxicity Tests with Fish, Macroinvertebrates, and Amphibians, U.S. Environmental Protection Agency, Corvallis, OR 63 pp.
NIOSH (2007). International Chemical Safety Card for NMP|(ICSC 0513), available online at|www.cdc.gov/niosh/ipcsneng/neng0513.html, request dated 16|Mar 2007.
Degussa (1994). 94-0355-DGM, Mouse Micronucleus test on|Dynasylan GLYMO.
IPCS (International Programme on Chemical Safety). (2002).|N-ethylmorpholine, No.0480.
Skin irritation / corrosion, IUC4#101/Ch.5.2.1
Simmon, V.F. (1979), "In Vitro Mutagenicity Assays of|Chemical Carcinogens and Related Compounds with Salmonella|typhimurium", J. Natl. Cancer Inst., Vol. 62, No. 4, pp.|893-899
BRRC, study report no. 93U1227 A, 09 Feb. 1995 (sponsored by|Union Carbide Corporation)
Method: other: Similar to OECD 474 using peripheral blood
TGD, 2003, Technical Guidance Document on Risk Assessment,|European Chemicals Bureau, Chapter 4 "Use of (quantitative)|structure activity relationshiipsa ((Q)SARS) in risk|assessment"
Method: other: calculated according to TGD
Huntsman Corp. (2001). Ethyleneamines. Technical Leaflet,|Houston, Texas.
Genetic toxicity in vitro, IUC4#27/Ch.5.5
Ciba-Geigy Ltd., Report on eye irritation in the rabbit|after single application of TK 10044, Project No 811494,|1.3.1982.
Lu GH, Wang C, and Bao GZ (2003). Quantitative|structure-biodegradation rates of substituted benzenes by|river bacteria. Environ. Tox. Chem. 22 (2), 272-275.
Atkinson,R., Environ. Toxicol. Chem.7, 435-442, (1988)
BASF AG, Laboratory of Ecology, unpublished data, 20.02.1979, No information
BASF AG: Department of Toxicology, unpublished study, Report on the study of the acute oral toxicity of Isobutylacrylat in the mouse, (XII/248), October 04, 1962
Penninks, A.H., M. Bol-Schoenmakers, M. Gielen, and W. Seinen. 1989. Comparative study with di-n-butyltin dichloride and various Sn-O bonded di-n-butyltin derivatives on the macromolecular synthesis of isolated thymocytes and the in vitro and in vivo antitumor activity. Journal Not Specified. XII:1-15.
Hafsah Z, Tahara S, Mizutani J (1984) Fungal Metabolism of|Dichloronitrobenzenes. J Pesticide Sci 9: 117 - 123
Salmonella typhimurium strains TA98, TA100, TA1535, TA1537, and TA1538
Method: other: see Method and Test conditions
Bayer AG (1976) 4-Nitrotoluol Untersuchungen zur akuten|Toxizität. Bayer Report No: 5803, January/05/1976
Method: other: exposure to dust, post exposure observation time: 7 days
NISSAN CHEMICAL INDUSTRIES, LTD. Unpublished report
Method: other: Estimated value with WSKOW v1.41
Hansch C and Leo A (1979). Substituent Constants for|Correlation Analysis in Chemistry and Biology. Pomona|College. John Wiley and Sons, New York.
Rodriquez-Arnaiz RR, Aranda JH (1994) Activity of aromatic|amines in the eye: w/w+ somatic assay of Drosophila|melanogaster. Environm. Mol. Mutagen. 24: 75-79
Method: other: w/w+ assay according Vogel et al., 1991, Mutat. Res. 250, 291; statistical evaluation: chi-square for proportions
Genetic toxicity in vivo, IUC4#29/Ch.5.6
Alexander, Lustigman (1966): J. Agr. Food Chem. 14, 410-413
Longstaff E (1978). The implant test. Br. J. Cancer 37,|954-958.
Short-term toxicity to aquatic invertebrates, IUC4#37/Ch.4.2
BASF AG, Fine Chemicals Product Database, status 22.07.2002
Eckert, J.W., Fungistatic and Phytotoxic Properties of Some|Derivaties of Nitrobenzene, Phytopathology 52, 642 - 649|(1962)
EPA's ECOSAR model (v. 0.99f). EPISUITE v.3.10, U.S.|Environmental Protection Agency (2000).
human xeroderma pigmentosum cell lines (XP19, XP20)
Method: other: carcinogenicity study (see chap. 5.7)
Trénel J and Kuehn R (1982). Bewertung wassergefaehrdender|Stoffe im Hinblick auf Lagerung, Umschlag und Transport und|Untersuchung zur Abklaerung substanz- und|bewertungsmethodenspezifischer Grenzfaelle bei der Bewertung|wassergefaehrdender Stoffe. Umweltforschungsplan des|Bundesministers des Innern, Forschungsbericht. Institut fuer|Wasser-, Boden- und Lufthygiene des Bundesgesundheitsamtes,|1-47.
Method: other: Bringmann and Kuehn (1980)
Mitsubishi Chemical Safety Institute Ltd. (2002a). Acute|toxicity of sodium gluconate with Daphnia magna. Study|number A010388. Study sponsored by Fujisawa|Pharmaceutical Co., Ltd.
Chemfinder (2006). Internet database, available online at|http://chemfinder.cambridge.com, request 05 Jan 2006.
Yuan X, Lu G, Lang P (1997) QSAR Study of the Toxicity of|Nitrobenzene to River Bacteria and Photobacterium|phosphoreum. Bull Environ Contam Toxicol 58: 123 - 127
Method: other: Bacterial growth inhibition test according to the protocoll from Alsop et al. (1980)
Toxicity to microorganisms, IUC4#190/Ch.4.4
Mesch, K.A. and T.G. Kugele. Morton International, Inc. 1992. Use of Organotin Stabilizers - Risk Assessment Analysis. J. Vinyl Tech. 14:131-134.
BASF AG, Laboratory of Ecology, unpublished data,(No.1067) |(Fixapret CP; 28.08.80)
Method: other: Short term respiration test
Method: T31-18:Guideline for Screening Mutagenicity Testing of Chemicals(Chemical Substances Control Law of Japan) and OECD Test Guideline 473
Kanitz, S., Franco, Y., Patrone, V., Caltabellotta, M.,|Raffo, E., Riggi, C., Timitilli, D. and Ravera, G. (1996):|Association between drinking water disinfection and somatic|parameters at birth. Environ Health Perspectives, 104,|516-520.
Hatano Research Institute (1999) N-(1,3-|Dimethylbutyl)-N'-phenyl-p-phenylenediamine - Summary. Tox|Testing Rep Environ Chemicals 7: 513-516
Method: other: OECD Guide-line 473, Guidelines for Screening Toxicity Testings of Chemicals (Japan)
Stull, D.R.: Vapor pressure of pure substances. Organic|compounds. Ind. Engin. Chem. 39, 517-540 (1947)
Yoo, Y. S.: Osaka-shi Igakkai Zasshi 34, 267-288 (1985)
BASF AG, Department of Product Safety, unpublished|calculation, 25.06.2001
Method: other: calculated with PCKOCWIN v1.63
Deneer JW, van Leeuwen CJ, Seinen W, Maas-Diepeveen JL,|Hermens JLM (1988) The Toxicity of Aquatic Pollutants: QSARs|and Mixture Toxicity Studies, Chapt. II. A QSAR study of the|toxicity of nitrobenzene derivatives towards Daphnia magna,|Chlorella pyrenoidosa and Photobacterium phosphoreum.|Dissertation, University of Utrecht
Method: other: OECD Guideline 201 (1984)
Salmonella tryphimurium TA98,TA100,TA1535,TA1537,TA1538, Escherichia coli WP2uvrA
Beilstein (2003). Handbook Register Number: 741981, Last|Update: 2003-04-17.
Method: other (measured): ebulliometric method in water
Zhang A, Dongbin W, Liansheng W (2000) QSAR Research on|Toxicity of Chlorinated Aromatic Compounds to Green Algae|based of Molecular Connectivity Indices. Huanjing Huaxue 19|(3): 220 - 224
Dressler: Dissertation Wuerzburg 1910: cited in Flury, F.|and Zernik, F.: Schaedliche Gase, Berlin (1931)
Schering AG. 1995. The temperature dependence of the vapour pressure of DBTO (ZK 26 385). Study No. 91/135. Report Nr. APC 20/94. 23.05.1995.
Toxicity to terrestrial plants, IUC4#4/Ch.4.6.2
Method: other: according Moreau et al., 1976
Repeated dose toxicity: oral, IUC4#26/Ch.5.4
Ismail, Salama, Ouf, Ouf (1988) Egypt. J. Microbiol. 23(1):29-41.
IRDC (1973) Eye Irritation in the Albino Rabbit.|International Research and Development Corporation (IRDC).|Study #: 328-004. Study Date: October 31, 1973.
Method: other: Federal Hazardous Substances Act, Chapter II, Title 16 CFR
Chemfinder. 2001. http://chemfinder.camsoft.com
BASF AG, Abteilung Toxikologie, unveroeffentlichte|Untersuchung, (XIX/401), 23.06.1970
BASF AG, Physikalisch-chemische Konstanten,|unveröffentlichte Untersuchung, BRU 77.126, 02.12.1977
Lonza AG, unpublished report, 1990, Verteilungskoeffizient, Lonza Report No. 1592
Ishidate M. et al. (1984). Fd Chem. Toxic. 22, 623.
Wang Z (2002) Simulation of the accumulation and degradation|of nitroaromatics in fish by a biomimetic sampling|technology. Acta hydrobiologica sinica 26 (3): 209 - 214
Amlacher, E. and C. Rudolph (1981) Arch.|Geschwulstforschung, 51(7), 605-610.|Amlacher, E. and C. Rudolph (1983) Acta histochemica|Suppl.-Band XXVII, 155-162.
Chen et al. (1988): Acta Microbiol. Sin. 28(4), 313-318
MERCK KGaA, 2000, Safety Data Sheet, Choline Chloride,|17 Oct. 2000
Solubility in organic solvents / fat solubility, IUC4#8/Ch.2.6.1
Method: other: in general conformance with OECD 479
Fleig I, Zober A (1989) The use of cytogenetic monitoring in|occupational medicine: a summary of choromosome analyses.|Poster presented at: Biomonitoring and carcinogen risk|assessment, Queen's College, Cambridge, England, 27-28 July|1989
Genetic toxicity in vivo, IUC4#20/Ch.5.6
Schaper M and Brost MA, 1991. Respiratory Effects of|Trimellitic Anhydride Aerosols in Mice. Arch Toxicol. 65(8):|671-677.
Method: other: Aerosol dissolved in acetone
KEMI Report No. 11/94. 1994. Mono- and Di- Substituted Organotins Used as Plastic Additives. Volume 1. L. Freij (ed.). Environmental Hazard Assessment. The Swedish National Chemicals Inspectorate. p. 12.
Younger Laboratories Inc. (1972). Toxicological|investigation of dicyclohexylamine (at the request of|Monsanto CO). EPA OTS 545735.
Method: other: 24-hour exposure; 0.5 ml applied undiluted, observed for 72 hours, evaluated according to F.H.S.A. = Federal Hazardous Substances Act
Zhao, Y.-H. et al., Quantitative structure-activity|relationships of nitroaromatic compounds to four aquatic|organisms, Chemosphere 34 (8), 1837-1844 (1997)
Method: other: comparable to OECD Guideline 203 (Fish: Acute Toxicity Test, 1992)
National Cancer Institute (1979): NTIS/PB 298539
MITI (Ministry of International Trade and Industry)(1992).|Biodegradation and Bioaccumulation Data of Existing|Chemicals Based on the Chemical Substances Control Law|(CSCL). Japan. Chemicals Inspection and Testing Institute|(CITI, ed.); Japan Chemicals Industry Ecology-Toxicology and|Information Center 3-44.
Method: other: OECD TG 305C "Bioaccumulation: Test for the Degree of Bioconcentration in Fish"
LPT-Report 5918/90, 13. April 1994, unveröffentlicht
EC2290 and X-188 resins with cover letter, OTS84003A (1982)
Gabridge, M.G. and Legator, M.S.: Proc. Soc. Exp. Biol. Med.|130, 831-834 (1969)
Heukelekian H and Rand MC (1955). Biochemical oxygen demand|of pure organic compounds. J. Water Pollut. Contr. Assoc.|27, 1041.
Reinert KH: Aquatic Toxicity of Acrylates and Methacrylates:|Quantitative Structure-Activity Relationships Based on Kow|and LC50. Reg. Toxicol. Pharmacol. 7, 384-389 (1987)
Method: other: according to American Society for Testing and Materials (ASTM, 1980)
Method: other: according to Gabridge and Legator, Proc. Soc. Exp. Biol. Med. 130, 831 (1969)
Genetic toxicity in vivo, IUC4#157/Ch.5.6
FMC Corporation Material Safety Data Sheet: Ammonium|persulfate (19-07-01: date approved), 2001.
Vogel, E.W. and Zijlstra, J.A.: Mutat. Res. 182, 243-264|(1987), No information
Method: other: SMART = Somatic mutation and recombination test
Genetic toxicity in vivo, IUC4#75/Ch.5.6
FMC Corporation, Acute toxicity of sodium persulfate to the|water flea (Daphnia Magna), Study no. I92-1252, 1993.
Basler A, v. d. Hude W, and Scheutwinkel-Reich M (1985).|Formaldehyde-induced sister chromatid exchanges in vitro and|the influence of the exogenous metabolizing systems S9 mix|and primary rat hepatocytes. Arch. Toxicol. 58, 10-13.
CIT (Centre International de Toxicologie) (2001). Lauryl|lactam: Preliminary study of prenatal development toxicity|by oral route (gavage) in rats. Report No. 20870 RSR|(unpublished)
Ruhoff JR (1933) The Nitration of o-Dichlorobenzene. J Amer|Chem Soc 55: 3470 - 3471
Melting point/freezing point, IUC4#9/Ch.2.1
Method: other: according to Clive et al., 1979, Mutation Res. and Brusick, 1980
Genetic toxicity in vitro, IUC4#94/Ch.5.5
Hildenbrand M, Rilke D, Luckner L (1998) Umweltverhalten und|numerische Simulationsmöglichkeiten des Schadstofftransports|sprengstofftypischer Verbindungen am Beispiel Standort|Torgau-Elsnig. In: Statusseminar Biologische Verfahren zur|Bodensanierung, pp 92 - 98
Adsorption / desorption, IUC4#8/Ch.3.3.1
Krichevskaya I.M. Gig Sanit 33, 24-28, (1968)
SafePharm Laboratories Limited (1991) Dynasylan IBTEO: Oral|gavage teratology study in the rat. Project number 395/2.|Degussa-Huls AG-Nr.: 91-0243-DGR May 29, 1991
Method: other: Dutch Standard Organisation NEN 6502 (1980)
Long-term toxicity to aquatic invertebrates, IUC4#4/Ch.4.5.2
Pauluhn J (2004a). Analysis of bronchoalveolar-lavage following acute inhalation toxicity in rats (exposure: 1 x 6 hours). Bayer HealthCare AG Report No. AT01428 (unpublished).
Method: other: OECD Guideline 403 (1981), adjusted to fulfill 92/69/EEC;93/21/EEC B.2 and FIFRA § 81-2 (1984)
Degussa AG (1978). Prüfung von Calciumformiat im|Hautreiztest am Kaninchen. Degussa AG -US -IT-Nr. 0015 DKT.
Dixon D, Rissmann E (1985). Physical-Chemical Properties and Categorization of RCRA Wastes according to Volatility. US EPA-450/3-85-007.
Genetic toxicity in vivo, IUC4#12/Ch.5.6
BASF AG, Safety data sheet BETA-IONON R, 27 Aug. 2004
Temenak, J.J. et al.: Environ. Mol. Mutagen. 15, 59 (1990);|abstract no. 222, No information
Genetic toxicity in vivo, IUC4#49/Ch.5.6
Ministry of Health & Welfare, Japan (1999): Toxicity Testing|Reports of Environmental Chemicals, vol.7 p163-171,|"Preliminary Reproduction Toxicity Screening Test of|2-Amino-5-methylbenzenesulfonic acid by Oral Administration|in Rats".
BHK21 cells (Baby Hamster Kidney fibroblast)
Buchbauer G., Jirovetz L., Jäger W., 1991, Aromatherapy: evidence for sedative effects of the essential oil of lavender after inhalation, Z. Naturforsch. 46c: 1067-1072
Method: other (calculated): with SRC-KOWWIN v1.67, 2000
Union Carbide Corporation. Mellon Institute of Industrial|Research. Project Report No. 13-54. Export, PA. 1950.
Hoechst AG (1991): Unveröffentlichte Untersuchung (W 88-062)
Probst GS, McMahon R., Hill L, Thompson C, Epp J, Neal S (1981) Chemically induced unscheduled DNA synthesis in primary rat hepatocyte cultures: a comparison with bacterial mutagenicity using 318 compounds. Environmental Mutagenesis 3:11-32.
Clariant GmbH, (2003b) Unpublished testing report titled|"o-Chlorobenzyl chloride Mammalian Erythrocyte Micronucleus|Test in Male and Female Sprague Dawley Rats", Report No:|PT02-0413, 04-Mar-2003, conducted by Aventis Pharma|Deutschland GmbH.
Moreno, O.M., Report to RIFM, 2 July 1977 cited in Fd.|Cosmetic. Toxicol. 17 (Suppl.), 895 (1979)
Mitchell AD (1993). Does the in situ approach yield a more|accurate assessment of induced mutation frequencies than the|standard L5178Y tk+/- mouse lymphoma assay? Environ. Molec.|Mutagen. Abstr. 21 Suppl. 22, 49.
Method: other: calculated using ECOSAR (ver. 0.99 g)
Nagasawa H, Fujimoto M. (1973) Experimentia 29, 89. Cited in|BIBRA Toxicity Profile
Harvey JS, Howe JR, Lynch AM, Rees RW (2005) The results of five coded compounds: genistein, metaproterenol, rotenone, p-anisidine and resorcinol tested in the pH 6.7 Syrian hamster embryo cell morphological transformation assay. Mutagenesis 20(1):51-56.
Method: other: OECD, FDA and MHLW methods
BASF AG, Department of ecology; unpublished report (7.11.88)
BioReliance (2002) Bacterial Reverse Mutation Assay with an|Independent Repeat Assay, Study No. AA49NY.502001.BLT,|Project No. 01-020, February 27, 2002.
Hoechst AG (1975b) Akute orale Toxizität von|4-Chlor-1-nitrobenzol an weiblichen SPF-Wistar Ratten.|Unveroeffentl. Unters. Bericht: 75.0485, 14. Oct. 1975
Method: other: 10 rats/dose,TS dissolved in sesame oil, observation time 14 days, pathologic examination, statistical analysis
University of Wisconsin. EPA/OTS Document 400-83 20709|(ATSDR/OTS 0511305) (1982a).
Method: other: in general conformance with OECD 477
Skin irritation / corrosion, IUC4#22/Ch.5.2.1
Casto, B.C. et al.: Chem. Biol. Interact. 13, 105-125|(1976);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Method: other: comparable to OECD Guide-line 301 D
Salmonella typhimurium TA1535, TA1537, TA98, TA100
Grafstrom, R.C.: Mutat. Res. 238, 175-184 (1990), No information
Genetic toxicity in vitro, IUC4#195/Ch.5.5
Tonogai Y., Ogawa S., Ito Y. and M. Iwaida (1982).|J. Toxical. Sci., 7:193-203
Method: other (measured): OECD Guide-Line 1979
Ullmann's Encyclopedia of Industrial Chemistry, 6th edition,|2000
MHLW, Japan (2004c) Ministry of Health, Labour and Welfare: Reverse mutation test of 4-Methylbenzoic acid in bacteria. Japan Toxicity Testing Reports of Environmental Chemicals, 11, 229-233.
Method: other: OECD Test Guideline 471 and Japanese test guideline
Repeated dose toxicity: oral, IUC4#16/Ch.5.4
Grant, W.M., Schuman, J.S., 1993. Toxicology of the Eye,|Fourth Edition. Charles C. Thomas, Springfield.
Biodynamics Inc. data, Project No. 98-3531, July 29, 1991 (at the request of Synthetic Organic Chemical Manufacturers Association)
Repeated dose toxicity: oral, IUC4#140/Ch.5.4
Zissu D, Binet S and Limasset JC (1998). Cutaneous sensitization to some polyisocyanate prepolymers in guinea pigs. Contact Dermatitis 39, 248-251.
Hoechst AG (1991): Unveroeffentlichte Berechnung des log Pow|(08.06.1991)
Method: other (calculated): Leo, Hansch: Medchem-Software CLOGP3, Release 3.42, PomonaCollege, Clermont CA
BASF AG, Department of Toxicology, unpublished data|(XXIII/533), 10/3/1974
BASF AG, Labor fuer Umweltanalytik; unveroeffentlichte|Untersuchung (09.01.1989)
Method: other (calculated): Inkrementenmethode von Rekker mit Computerprogramm der Firma CompuDrug Ltd.
IARC (1992) Sulfur dioxide and some sulfites, bisulfites and|metabisulfites. IARC Monograph 54: 131-188
American Cyanamid Co. (1987a). A closed-patch repeated insult dermal sensitization study in guinea pigs with TDI, MDI, p-TMXDI, IPDI, m-TMXDI, HMDI and m-TMI, Project No. 4971-84. NTIS/OTS Microfiche 0515234, Doc 86-870000795.
Method: other: Closed patch test; modified Buehler method, Buehler EV (1965). Arch. Dermatol 91, 171-175; Ritz HL and Buehler EV (1980). In: Drill VA and Lazar P (eds.): Current Concepts in Coutaneous Toxicity, Academic Press, 25-40.
Ciba (1994). Cytogenetic Test on Chinese Hamster Cells in|vitro. Unpub-lished report # 944071. December 12, 1994.
CIBA-GEIGY, Ltd. 1980. Report on Skin Irritation in the Rabbit after Single Application of TK 10701. Project No.: 801410. 21.08.1980.
Method: other: EPA, §163.81.5, Federal Register Vol. 43, No. 163.
Method: other: comparable to OECD Guide-line 408
Dow Chemical Company, unpublished report (1991). Cited in|attachment 1 to a letter from DOW dated 17 May 1994.
Figge, K., Koch, J., 1973, NATEC, Gesellschaft fur naturwissenschaftliche Dienste mbH. Migration of the Methyltin Stabilizer Advastab TM-181-FS from Rigid PVC in the Fat Simulant HB 307. April 1973.
BASF AG (1979) Department of Toxicology. Bericht über die|gewerbetoxikologische Grundprüfung. Unpublished report No.|77/807, dated Jan 15. 1979.
Method: other: According to Draize (FR 38, No. 187, §1500.42 p. 27019 (1973)
Chemicals InspectionI and testing Institute, Japan (1998): report on biodegradability
Biodegradation in water and sediment: simulation tests, IUC4#1/Ch.3.5
Pharmakon Research International, Barfknecht TR (1984 a)|Ames Salmonella/microsome plate test (EPA/OECD) PH|301-UN-002-84 Flexzone 7F. Unpublished study of Uniroyal|Chemical Co.
Ministry of Health and Welfare: Japan, Toxicity Testing Reports of Environmental Chemicals 4, 547-556 (1996)
Ziegenbein W, Lang, W (1962). Undecyl- und Laurinlactam aus|Cycloundecan- und Cyclododecancarbonsäure. Angew. Chem. 74,|943
Hammond, P.D., Kirk-Othmer Encyclopedia, 3 (1949) 840.
Method: other: Fuetterungsversuch [feeding study]
Toxicity to terrestrial arthropods, IUC4#1/Ch.4.6.4
Florin, I. et al.: Toxicology 15, 219-232 (1980)
Kushi A and Yoshida D (1987): Antimutagenic Effects of|Phenols on MNNG-induced Mutagenesis in Escherichia coli.|Agric Biol Chem 61(5), 1439-1440.
TNO (1984) Primary Dermal Irritation/Corrosive Test with|Butanox M-50 in Albino Rabbits. Central Institute for|Nutrition and Food, TNO. Study #: V84.155/240061; Project|No. B84-0061/3. Study Date: May, 1984.
Method: other: EEC Directive 79/831, Annex V, Part B
Dow Corning Corporation Internal Report Number|1979-I0005-676. Mutagenicity Evaluation of|[3-Glycidoxypropyltrimethoxysilane] in the Ames Bacterial|Assay.
BASF AG, Department of Ecology, unpublished calculation,|Dec 18, 1998
OECD Guideline 410 (Repeated Dose Dermal Toxicity: 21/28-Day Study)
Hanstveit AO, Kappers FI, and Canton JH (1985). Research for|a Useful Combination of Tests Methods to Determine the|Aquatic Toxicity of Environmentally Dangerous Chemicals|Rep.No.R85/083, Natl. Inst. Public Health Environ. Hyg., 26|pp (DUT).
Toxicity to aquatic algae and cyanobacteria, IUC4#140/Ch.4.3
Couch DB, Allen PF, Abernethy DJ (1981). The mutagenicity of|dinitrotoluenes in Salmonella typhimurium. Mutat Res 90,|373-383.
Method: other: according to Ames B.N. et al., Mutat. Res. 31, 347-364 (1975)
IOMC (2001). N-Methyl-2-pyrrolidone. Concise international|chemical assessment document No. 35, first draft.
Boczek, J. et al.; J. Georgia Entomol. Soc., vol. 19, 235 -|248 (1984).
Method: other: Ammoniumpersulfate was mixed with a wheat germ diet; tests were conducted at 25 degree C and 85 % relative humidity; control group: yes
Yonkos LT, Fisher DJ, Wright DA and Kane AS (2000). Pathology of fathead minnows (Pimephales promelas) exposed to chlorine dioxide and chlorite. Marine Environmental Research, 50, 267-271.
Roederer, G., Testung wassergefaehrdender Stoffe als|Grundlage fuer Wasserqualitaetsstandards.|Fraunhofer-Institut fuer Umweltchemie und Oekotoxikologie,|5948 Schmallenberg, UFOPLAN-Nr. 116 08 071/01, 79 p. (1990)
Method: other: OECD Guide-line 203 (1984)
Salmonella typhimurium strains TA98 and TA100
Damgard Nielsen G., Hougaard K.S., Larsen S.T., Hammer M.,|Wolkoff P., Clausen P.A., Wilkins C.K., and Alarie Y.|(2001). Acute airway effects of formaldehyde and ozone in|BALB/c mice. Hum.Exp.Toxicol. 18, 400-409., No information
Method: other: sensory irritation test according to Alarie
Acute toxicity: inhalation, IUC4#15/Ch.5.1.2
Horton, A. W. et al.: J. Nat. Cancer Inst., 30, 31-43,|(1963) cited in: Pepelko, W. E.: Environmental Research 33,|144-188, (1984), No information
Atkinson (1987) : Intern. J. Chem. Kin. 19, 799-828
Hansch C, Leo A, and Hoekman D (1995). Exploring QSAR. Hydrophobic Electronic and Steric Constants. ACS (American Chemical Society) Professional Reference Book. Washington D.C, 14, 35, 201.
Yamano, Y., 1991. Experimental study on methyl bromide|poisoning in mice. Acute inhalation study and the effects of|glutathione as an antidote. Jpn. J. Ind. Health 33:23-30 (in|Japanese).
Weast, R.C. (1986), "CRC Handbook of Chemistry and Physics,|66th edition"
BASF AG (1986). Department of Toxicology, study No. 85/289,|05 Feb 1986 (unpublished).
Method: other: German Industrial Standard DIN38412 Part 15
Lyman WJ, et al. (1990) Handbook of Chemical Property Estimation Methods Washington, DC: Amer. Chem. Soc., p. 4-9.
Adsorption / desorption, IUC4#20/Ch.3.3.1
Repeated dose toxicity: oral, IUC4#25/Ch.5.4
Monsanto Co (1980b) Salmonella mutagenicity assay of CP6560.|Report DA-79-0258, 22. April 1980, EPA-OTS0557082 and|EPA-OTS0543012
Method: other: according to Ames et al., Mutat. Res. 31: 347 (1975) and MRC's Standard Operating Procedure for S. typhimurium, Rat S9-mix, Mouse S9-mix
Genetic toxicity in vitro, IUC4#28/Ch.5.5
Flaks A. und Clayson B.D.: Br. J. Cancer, 31, 585-587,(1975)
IITRI. 1989. Thirteen-week inhalation toxicity study of|trimellitic acid (TMLA) in rats. Final Report. IIT Project|No. L8100, Study No. 1424, Test Article No. 228C.
Method: other: Thirteen-week inhalation toxicity study
Bringmann, G. and Kuhn, R. (1978) Testing of Substances for|Their Toxicity Threshold: Model Organisms Microcystis|(Diplocystis) aeruginosa and Scenedesmus quadricauda.|International Association of Theoretical and Applied|Limnology. Communications, 21: 275-284.
Luijten JGA and Klimmer OR (1973) A toxicological evaluation|of the organotin compounds, Tin Research Institute.
Defitraces (2003) Report No. 02-902003-064. Boiling point of|EHTG. April 3, 2003.
Houpt JT, Reddy G, Crouse LC (2003). Developmental toxicity|of thiodiglycol in rats. Toxicologist 2003, 72 (S-1): 341
Nakano, Y. :Allergicity of Epoxy Resins, Acrylic Resins and|their Hardeners, Osaka-furitsu Koshu Eisei Kenkyusho|Hokokku, Rodo Eisei Hen, 15, 33-36(1977)
EPI Suite v3.12 (August 17, 2004) U.S. Environmental|Protection Agency.
BASF AG, Laboratory of Ecology, unpublished data (1980)
Biodegradation in water: screening tests, IUC4#3/Ch.3.6
Grade R, 1993, Report on the acute toxicity of linalylacetat on daphnia (Daphnia magna Strauss 1820), Ciba-Geigy Ltd.
International Labour Organization. (2002). ICSC: 0480.
Bailey HC, Spanggord RJ, Javitz HS, Liu DHW (1984). Toxicity|of TNT wastewaters to aquatic organisms, Vol. IV. Chronic|toxicity of 2,4-dinitrotoluene and condensate water|(AD-A153536). SRI International, Menlo Park, California,|USA: 80 pp.
Method: other: Early life stage test, see TC
Long-term toxicity to fish, IUC4#25/Ch.4.5.1
Daubert, Danner. (1983) Data Compilation Tables of|Properties of Pure Comp., AICHE/DIPPR
Chemicals Evaluation and Research Institute (CERI), Japan.|Product data sheet. MPBPWIN v1.40, 31.07.2003.
BASF AG, Department of Toxicology, unpublished data on the|study of Glyezin A in the Ames test, Report Project No.:|40M1018/884405, 20. March 1989
Method: other: OECD Guide-line 471, 1983
Monsanto Study No. SR-81-46 as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Genetic toxicity in vitro, IUC4#140/Ch.5.5
Golub NI, Kolesnichenko TS, Shabad LM (1974) Oncogenic|action of some nitrogen compounds on the progeny of|experimental mice. Byull Eksp Biol Med 78: 62-65; English|translation Bull Exp Biol Med 78: 1402-1404
Method: other: tumor development in progeny
Kuehn R, Pattard M, Pernak K-D, Winter A (1988). Damaging|Effects of Environmental Chemicals in the Daphnia|Reproduction Test as a Basis for Evaluation of Environmental|Hazard in Aquatic Systems. Report of Umweltbundesamt,|UFOPLAN Nr. 106 03 052.
Method: other: DIN-Standard 38 412 L11 (Daphnia, Short-time toxicity test)
Dow Corning Corporation (2007) An Acute Whole Body|Inhalation Toxicity Study of Hexamethyldisilazane in|Sprague-Dawley Rats. Report Number: 2007-I0000-57886|(sponsored by the Silicone Environmental Health and Safety|Council).
Norris, J.M. (1971) Eye and skin irritation properties of|DOWFLAKE calcium chloride. Unpublished Dow Chemical Company|report.
Method: other: US Federal Hazardous Labeling Act. procedures recommended by the FDA CFR, Part 191, Chapter 1, Title 21, January 1, 1970.
Skin irritation / corrosion, IUC4#60/Ch.5.2.1
Pohl, E (2008) Hydrolysis Modeling of Octyltriethoxysilane|and Isobutyltriethoxysilane. Unpublished Study report for|SEHSC. October 23, 2008.
Hawley's Condensed Chemical Dictionary. 1987. N.I. Sax and R.J. Lewis, Sr. (eds.). 11th ed. Van Nostrand Reinhold Co. New York, NY. p. 192.
BASF AG (2001). Department of Experimental Toxicology and|Ecology, unpublished data, project No. 00/0969/51/1, 25 Jul 2001
Hoechst AG (1981). Department of toxicology.|Inhalationstoxizität im Zeitsättigungstest von Ameisensäure|z. Analyse, min. 98% (Merck 264) an männlichen und|weiblichen SPF-Wistar-Ratten. Unpublished study report No.|602/81, dated 12 Nov. 1981.
EPA (2003) EPIWIN Calculations 1,4-Benzenediamine,|N-(1,3-dimethylbutyl)-N´-phenyl-
Winters G, Geoffroy A (1991). FAT 65'023/N: Vapour pressure|curve. CIBA-GEIGY Ltd., CH-4002 Basel (Switzerland); Test|No. FC-90/30 T.
Bloom A, Galloway S, Nakamura FT, Teteviri A, Armstrong M,|Lavappa KL, Duk S, Ahmed MA (1982) Comparison of results for|SCE and chromosome aberrations for eleven compounds tested|in two laboratories by standardized methods. Environm|Mutagen 4: 397
Latven A. et al., Comparison of the toxic, hypnotic And|irritating properties of 8 organic solvents, J. Pharm. Exp.|Ther., 65:89-94, 1939 (51)
Huntingdon Research Centre Ltd. (1987) Acute dermal toxicity|to rats of Isobutyltriethoxysilane. Report 87380D/DNN 12/AC.|Degussa-Huls AG-Nr.: 87-0271-FGT May 21, 1987
Elf Atochem NA. 1993. An acute oral toxicity study in rats with [mono/di] methyltin chlorides solution. Study conducted by Springborn Laboratories, Inc. SLS Study No. 3255.10. July 26, 1993.
Method: other: similar to EPA TSCA Guideline No. 798.1175 and OECD Guideline 401
Devillers J, Chezeau A, Poulsen V and Thybaud E. 2003.|Effects of glycol ethers on the reproduction of Ceriodaphnia|dubia. Chemosphere 50: 373-376.
Degussa-Huls Ag (1995) Determination of the acute effects of|DYNASYLAN ATAC On the growth of Scenedesmus subspicatus|86.81.SAG (algae growth test per Guideline 92/69/EEC). Final|Report AW-415.|Degussa-Huls AG-Nr.: 95 0215. DGO. 8/21/1995.
Weisburger, E.K. et al.: Journal of Environmental Pathol-|ogy & Toxicology 2, 325-356 (1978)
de Vogel, N. 2003. Trichloromethylstannane [CASRN 993-16-8]: Micronucleus test in rat bone marrow cells. Report V3404/13. Department of Biomolecular Sciences, TNO Food and Nutrition Research, 3700AJ Zeist, The Netherlands. 14 January 2003.
BASF AG, Product Safety, unpublished data, 08B0598/006027,|15.11.2000
Method: other: measured: hydrolysis of 3,4-dihydro-2-methoxy-2H-pyran under simulated physiological conditions; test procedure according to an internal BASF standard
Method: other: OECD Guideline 201 (Algae, Growth inhibition test, 1984)
Toxicity to aquatic algae and cyanobacteria, IUC4#130/Ch.4.3
Kato, H.: Exp. Cell Res. 82, 383-390 (1973);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Deshpande SD, Chakrabarti T, Subrahanyam PVR, Sundaresan BB (1985) Biological treatability of m-aminophenol plant wastewater containing structural isomers of benzene with different substituents. Water Research 19:293-8 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
BASF AG (2006). Stoffdatenservice, ZAT/D - M325, unpublished|database extract, 31 Jan 2006.
Baglay A.K., Gurariy L.L. and Kuleshov G.G., 1988, Physical|properties of compounds used in vitamin synthesis, J. Chem.|Eng. Data, 33, 512-518
Method: other (measured): static method with a glass membrane as a null manometer
Union Carbide Corporation. Material Safety Data Sheet. |1998.
CIT (2006) Acute Oral Toxicity in Rats (Fixed dose method), Study number 26937 TAR. Study sponsor: L'Oreal.
Staples R., Gastrointestinal irritant effects of glycerin as|compared with sorbitol and propylene glycol in rats and|dogs, J. Pharm. Sci., 56(3):398-400, 1967 (66)
Bayer AG (2003). Internal Study: Acute Daphnia Toxicity.|Study No. 1290 A/03 D.
FMC Corporation, Ammonium persulfate: acute toxicity to the|freshwater green alga, Selenastrum capricornutum, under|static test conditions, Study no. I97-2227, 1998.
Bringmann G and Kuehn R (1980). Bestimmung der biologischen|Schadwirkung wassergefaehrdender Stoffe gegen Protozoen II.|Bakterienfressende Ciliaten. Z. Wasser- Abwasser Forsch. 1,|26-31.
Method: other: cell multiplication inhibition test according to Bringmann (1978)
Morita, T. et al., Chem. Pharm. Bull. 37, 407-409 (1989)
BASF AG, Product Safety, data assessment, SRC AOP v1.90, 25|Oct. 2002
TNO (1982) Examination of Butanox LPT for Mutagenic Activity|in the Ames Test. CIVO Institutes TNO. Study #: V|82.059/220064; Project No. B 82-0064/4. Study Date: March,|1982.
Method: other: Pre-dates OECD test guideline 471. Procedure followed Ames et al. (1975).
Stoner, G.D. et al. (1973), Test for Carcinogenicity of Food|Additives and Chemotherapeutic Agents by the Pulmonary Tumor|Response in Strain A Mice, Cancer Research 33, 3069-3085
BASF AG, Department of Ecology, Bestimmung der biologischen|Abbaubarkeit von 3-Methylbuten-2-al-1, unpublished study,|01.0569/87, 08 Dec. 1987
EU Method C.9 (Biodegradation: Zahn-Wellens Test)
Genetic toxicity in vitro, IUC4#173/Ch.5.5
Ullmann´s Encyclopedia of Industrial Chemistry, Sixth|Edition (2001)
Eastman Kodak (1964). In: TSCATS Doc#86-920000008: Letter|from Eastman Kodak Company to USEPA submitting enclosed|Toxicity & Health Hazard Summary, Material Safety Data Sheet|& Toxicity Reports on 3-hydroxy-2-naphthoic acid, 01 Oct|1991
Carpenter C.P. (1956). Range finding tests on|N-(2-aminoethyl)piperazine Unpublished UCC report 19-22.
EC, Technical guidance document in support of the Commission|Directive 93/67/EEC on risk assessment for new notified|substances and the Commission Regulation (EC) 1488/94 on|risk assessment for existing substances. European Chemicals|Bureau, Ispra, Italy (1996)
Adsorption / desorption, IUC4#20/Ch.3.3.2
DETERMINATION OF THE WATER SOLUBILITY|OF CAS RN: 2082-79-3 RCC Project No: A04803, 2006
Jones H. R., Environmental Control in the Organic and|Petrochemical Industries. Noyes Data Corp. 1971.
BASF AG, Safety data sheet FORMALDEHYDE 49-2015, 04.10.2002|(30034696) (contains approx. 49% formaldehyde in aqueous|solution), No information
Repeated dose toxicity: oral, IUC4#22/Ch.5.4
Magna-Schwencke, N. et al.: Mutat. Res. 50, 181-193 (1978), No information
Method: other: DNA damage and repair assay
Genetic toxicity in vitro, IUC4#150/Ch.5.5
Short-term toxicity to aquatic invertebrates, IUC4#21/Ch.4.2
Mast T, Evanoff J, Stoney K, Westerberg R and Rommereim R|(1989). Inhalation developmental toxicology studies:|teratology study of isoprene in mice and rats. Final report.|Govt. Rep. Announce. Index 14.
CIT (1993) Acute dermal irritation in rabbits with 2-ethylhexyl thioglycolate, CIT study no. 10266 TAL, 31 December 1993.
Method: other: according Kada et al. (1978)
Genetic toxicity in vitro, IUC4#56/Ch.5.5
I'Institut National de Recherche et de Securite (INRS) (2000). Fiche Toxicologique No. 178 on Resorcinol, Edition 2000.
Covance Laboratories (2005) Resorcinol (AO11) Reverse mutation in|five histidine-requiring strains of Salmonella typhimurium. Study number 413/67-D6171. Study Sponsor: L'Oreal.
Environmental Agency, Japan:(1998) unpublished report on|Fish, Acute Toxicity Test (No. 91909)
GESTIS Stoffdatenbank|5-Methyl-2-(1-methylethyl)cyclohexanol,|http://www.hvbg.de/d/bia/fac/zesp/zesp.htm (Print|25.03.2002)
DuPont, Gerber KM (1994) Urinary bladder toxicity - 14-day|feeding study with o-tuluidine in rats. Report DuPont HLR|699-93, OTS0557449
Method: other: Urinary bladder toxicity (see also freetext TC)
Schott CD and Worthley EG (1974) The toxicity of TNT and|related wastes to an aquatic flowering plant, Lemna|perpusilla Torr. Edgewood Arsenal, Report-No.EB-TR-74016
Method: other: according to Worthley (1971)
Monsanto Chemical Co. (1993) A combined chronic (24 month)|oral toxicity and oncogenicity study with Santoflex® 13 in|the rat via dietary admixture Study/Project No.|BD-87-151/Project No. 87-3178, unpublished report, cited|from BUA Report 208, 1996
Occidental Chemical Corporation (1990) Letter from|Occidental Chem Corp to US EPA submitting studies on|orthochlorobenzylchloride with attachments, EPA Doc#|89-900000417, NTIS/OTS0526421-1
Moriya, M., Ohta, T., Watanabe, K., Miyazawa, T., Kato, K.,|Shirasu, Y. 1983. Further mutagenicity studies on pesticides|in bacterial reversion assay systems. Mutat. Res., 116:|185-216.
Noda, T., T. Yamano, M. Shimizu, M. Saitoh, T. Nakamura, A. Yamada, and S. Morita. 1992. Comparative teratogenicity of di-n-butyltin diacetate with n-butyltin trichloride in rats. Arch. Environ. Contam. Toxicol. 23:216-222.
Mitsubishi Gas Chemical Co. USA, MSDS in English, 1998
Gansewendt, B., Foest, U., Xu, D., Hallier, E., Bolt, H.M.,|Peter, H., 1991. Formation of DNA adducts in F-344 rats|after oral administration of inhalation of [14C]methyl|bromide. Food Chem. Toxicol. 29:557-563.
Barnes, J.M. and H.B. Stoner. 1958. Toxic properties of some dialkyl and trialkyl tin salts. British Journal of Industrial Medicine. 15:15-23.
Monsanto Co. (1984) Nitrated orthene. A range-finding|methemoglobin study in pregnant rats (report no.|ML-84-106/840029). Monsanto Co., St. Louis (OTS0534379,|86-920000174)
Bringmann,G., Kuehn,R., Zeitschrift Wasser Abwasser|Forschung 10(3/4), 87-98, 1977, No information
Toxicity to microorganisms, IUC4#26/Ch.4.4
Shimizu M, Yano E (1986) Mutagenicity of mono-nitrobenzene|derivatives in the Ames test and rec assay. Mut Res 170:|11-22
Method: other: a pour-plate method according to Ames et al., Proc. Natl. Acad. Sci.(USA) vol.70, 782 (1973), pos. and neg. and solvent control, tested up to toxic effect, all tests performed in duplicate, repeated at least 3 times
FMC Corporation, FMC study no.: I79-326 (1979).
Bayer AG (2003) Dinitrotoluene 80/20 Material Safety Data|Sheet (2003-01-17)
Monsanto Co. (1987) Nitrated orthene. A methemoglobin study|in pregnant rats. Monsanto Co., St. Louis (OTS0534376,|86-920000171)
Greenlee. T.W. (1969) Dow Corning Corporation, Report No.|1969-I0030-3562.
Hoechst AG (1978): Unveröffentl. Unters. (Ber.-Nr. 78.0496)
Allied Corporation (1984) ORAL LD50 STUDY OF VINYL OXIMINO|SILANE. Internal Study. Allied Corporation Department of|Toxicology, Morristown, NJ. October 1, 1984
MOE, Japan (1996) Ministry of Environment: unpublished report of growth inhibition study of N-tert-butyl-2-benzothiazonylsulphenamide to algae (Selenastrum capricornutum)
BASF AG (1965) Abt Toxikologie, unpublished report XV/225-XIV/257, 31.12.1965.
Thomann P and Krüger L (1974a). FAT 65'023/C - Skin|irritation to rabbits upon single application. Report Exp.|No. 377/82, December 10, 1974. Toxicology/Pathology,|Parmaceuticals Division, Ciba-Geigy Ltd., Basel,|Switzerland.
Zielenska, M. and Guttenplan, J.B.: Mutat. Res. 202, 269-276|(1988), No information
Krötlinger F (1994). Isophorondiisocyanat, study for skin irritation/corrosion in rabbits. Report No. 22961 (unpublished). Bayer AG (Wuppertal).
Method: other: OECD Guideline 404 (1981)
ISO DIS 9509 (Method for Assessing the Inhibition of Nitrification of Activated Sludge Microorganisms by Chemicals and Waste Waters)
Bächtold H (1980): Toxicity report, Internal Communication|no 9027, Jun 16, 1980. F.Hoffmann-La Roche Ltd, Basle, Dept|TKA, unpublished internal report.
Method: other: former Roche gavage oral toxicity test
Brungs WA (1973) "Effects of residual chlorine on aquatic|life", J Water Pollut Cont Fed, 45, 2180-2193
Short-term toxicity to fish, IUC4#65/Ch.4.1
Bringmann, G. und Kuehn, R., Mitt. Internat. Verein.|Limnol. 21, 275-284 (1978)
Rusakov, N.V. et al.: Gig. Sanit. No. 3, 13-16 (1973)
Method: other: 3 drops of a 1 % solution to the clipped area of the skin for 5 d; on the 7th d 3 drops of the 1 % solution to an untreated area of the skin; reading time not mentioned
Mazaev, V.T., Troenkina, L.B. and Gladun, V.E. (1986) Effect|of aliphatic amines on reproductive function of animals. Gig|Sanit 51:66-68, October.
MITI (Ministry of International Trade and Industry) (1992).|Biodegradation and Bioaccumulation Data of Existing|Chemicals Based on the Chemical Substances Control Law|(CSCL). Japan. Chemicals Inspection and Testing Institute|(CITI, ed.); Japan Chemicals Industry Ecology-Toxicology and|Information Center 5 - 40.
Gafieva, Z.A. and Chudin, V.A.: Gig. Sanit 9, 81 (1986)
Ministry of Health & Welfare, Japan (1996) Toxicity Testing Reports of Environmental|Chemicals, Vol. 4, 529.
Liu DHW, Spanggord RJ and Bailey HC (1976) Toxicity of TNT|Wasterwater (Pink water) to aquatic organisms.|DAMD17-75-C-5056
Kuraray Co., Ltd.(2004), Material Safety Data Sheet on|3-Methoxy-3-methyl-1-butanol
MITI, Biodegradation and Bioaccumulation Data of Existing|Chemicals Based on the CSCL Japan, Compiled under the|Supervision of Chemical Products Safety Division, Basic|Industries Bureau MITI, Ed. by CITI, October 1992.|Published by Japan Chemical Industry Ecology-Toxicology|& Information Center
Draize JH, Woodard G, Calvery HO. 1944. Methods for the study of irritation and toxicity of substances applied to the skin and mucous membranes. Pharmacol Exp Ther 82:377-390.
Hüls AG (1988). Algenwachstumshemmtest nach UBA (Stand Feb. 1984) - Scenedesmus subspicatus, Produkt Isophorondiisocyanat. Report No. AW 145/1+2 (unpublished, 1 p).
Method: other: German Umweltbundesamt draft procedure (1984)
Onodera, H. et al., Eisei Shikenjo Hokoku 96, 47-55 (1978)
Blum, D.J.W. and Speece, R.E.: Ecotoxic. Environ. Safety|22:198-224 (1991b).
Woodruff RC, Mason JM, Valencia R, Zimmering S (1985)|Chemical mutagenesis testing in Drosophila. V. Results of 53|coded compounds tested for the National Toxicology Program.|Environ Mutagen 7: 677-702
Method: other: according to Woodruff RC et al. (1984) Environ Mutagen 6, 189-202, see also freetext ME
SRC (2006). Search results on formic acid, Chemfate|database, available online at|http://www.syrres.com/esc/chemfate.htm, request 05 Jan 2006.
Method: other: Bestimmung der Wirkung von Wasserinhaltsstoffen auf Fische, [Determination of the effect of water contaminants on fish] DIN38412, Teil [Part] 15
Honma M, Hayashi M, Shimada H, Tanaka N, Wakuri S, Awogi T,|Yamamoto KI, Kodani NU, Nishi Y, Nakadate M and Sofuni T|(1999a). Evaluation of the mouse lymphoma tk assay|(microwell method) as an alternative to the in vitro|chromosomal aberration test. Mutagenesis 14, 5-22.
John J.A. et al, 1983, Fundam. Appl. Toxicol., V3, P.437-42.
Preat, V. et al. (1986): Carcinogenesis 7, 1025 - 1028
Method: other: Initiation-Selection/Promotion Assay
Bayer A 1994, Acute toxicity of BHT to the alga Scenedesmus|subspicatus, test report 466 A/94
Method: other: Directive 67/548/EEC, C.3 "Algal inhibition test" (1992)
Method: other: Draize Test according to the US Food and Drug Administration, Federal Register No. 191-11
Linscombe, V. and Engle, K., Unpublished report of The Dow|Chemical Company (CHO/HPGRT assay) (1995)
Lead sulfochromate yellow (C.I. Pigment Yellow 34)
Method: other: OECD Guideline 201 (1984) with slight modifications (Van Leeuwen et al. 1985b)
National Institute of Technology and Evaluation (2002). Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law. Data on 4,4'-dichlorodiphenylsulfone. See: http://www.safe.nite.go.jp/english/kizon/KIZON_start_hazkizon.html
CIT (1994) Acute eye irritation in rabbits -|Isooctylthioglycolate, Centre International de Toxicologie,|Report no. 10271 TAL, January 1994.
Munk, R., Kirsch, P, (1988). Report on the Study of the|Acute Toxicity (in the Golden Orfe, Leuciscus idus l. of|Solvenon PP). BASF Aktiengesellschaft. Study No.|10F0406/875079, August 23, 1988. Unpublished report.
Method: other: Specific guidance not referenced. However, OECD Guideline 203 "Fish, Acute Toxicity Test" followed.
Fendrich, C., Degradation of glucose, glycerol and acetate|by aerobic bacteria in surface water of Great Salt Lake,|Utah, USA, System. Appl. Microbiol. 11, 94-96, 1988 (109).
Battelle Europe. 1993. A Study of the Acute Immobilisation|to Daphnia of Isophthalic Acid. Study Number: |BE0EA-128-91-02-DAK-2.
BASF AG, department of ecology, unpublished calculation,|07.07.2000
Method: other: calculated with HYDROWIN V 1.64
Steffensen IL, Paulsen JE, Engeset D, Kronberg L, Alexander|J (1999) The drinking water chlorination by-products|3,4-dichloro-5-hydroxy-2[5H]-furanone (mucochloric acid) and|3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone do not|induce preneoplastic or neoplastic intestinal lesions in|F344 rats, Balb/cA mice or C57BL/6J-Min mice. Pharmacol|Toxicol 85: 56-64
Demerec, M. et al.: Am. Nature 85 (821), 119-136 (1951);|cited in: RIFM database, location no. 3774
CIT (1993) Acute dermal toxicity in rats, 2-ethylhexyl|thioglycolate, CIT study no. 10265 TAR, 28 December 1993.
Florin I. et al. (1980). Toxicology 18, 219
BASF AG (1985). Department of Analytical Chemistry, report|BRU 85.15, 23 Jan 1985 (unpublished).
Method: other: determination of vapour pressure similar to OECD Guideline No. 104
Huntingdon Life Sciences Ltd. (1999). Tungsten carbide|powder - Pure. Eye irritation to the rabbit. Unpublished|Report No. ITU 017/982713/SE, September 8, 1999.
Piontek M (1999). Use of a planarian Dugesia tigrina Girard|in the studies of acute toxicity of organic substances. Pol.|Arch. Hydrobiol. 46 (3-4), 331-338.
Amoco Chemicals Co. (1993) A Study of the Acute|immobilisation to Daphnia of Terephthalic Acid. Conducted by|Battelle Europe; Study # BE-EA-128-91-02-DAK-3;
Hüls AG (1996a). Bestimmung der Auswirkungen von|Isophorondiamin auf das Schwimmverhalten von Daphnia magna.|Report No. DK-159 (unpublished).
Loeser E (1982). Bayer AG data, 2,4-Dinitrotoluol rein,|Untersuchungen zur akuten kutanen Toxizität an männlichen|und weiblichen Wistar-Ratten, August/12/1982.
Method: other: according to Noakes and Sanderson, Br. J. Ind. Med. 26, 59, 1969
Hamilton CM and Mirsalis JC (1987). Factors that affect the|sensitivity of the in vivo-in vitro hepatocyte DNA repair|assay in the male rat. Mutat Res 189, 341-347.
Method: other: according to Mitchell A.D., J.C. Mirsalis in : A.A. Ansari and F.J. de Serres (eds.)Single-Cell Mutation Monitoring Systems, Plenum, New York, 1984, p. 165-216
Bringmann G and Kuehn R (1980). Bestimmung der biologischen|Schadwirkung wassergefaehrdender Stoffe gegen Protozoen III.|Saprozoische Flagellaten. Z. Wasser- Abwasser Forsch. 13(5),|170-173.
Method: other: cell multiplcation inhibition test according to Bringmann (1978)
Zdravko, B.I. et al., Gigiena i Sanitariya, 0(2), 67-69|(1985)
Method: other (measured): at 25 degrees C
APCI, 1,4-Diazabicyclo[2.2.2]Octane: Fresh Water Algal|Growth Inhibition Test (OECD 201), unpublished study, APCI|RRRS EXT-00/031, 28 Feb 2000
Monteiro-Riviere, N.A. and Popp, J.A.: Fundam. Appl.|Toxicol. 6, 251-262 (1986), No information
Tsuda, T., H. Nakanishi, S. Aoki, and J. Takebayashi. 1986. Bioconcentration of butyltin compounds by round crucian carp. Toxicol. Environ. Chem. 12:137-143.
Chinese hamster fibroblast cell line CHL
Kronberg L, Sjöholm R, Karlsson S (1992) Formation of|3,N4-ethenocytidine, 1,N6-ethenoadenosine, and|1,N2-ethenoguanosine in reactions of mucochloric acid with|nucleosides Chem Res Toxicol 5: 952-855
Genetic toxicity in vitro, IUC4#54/Ch.5.5
Biosafety Reseach Center (2001) Preliminary reproduction|toxicity screening test of|N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine by oral|administration in rats. Tox Testing Rep Environ Chemicals 8|(2): 795-807
Taniguchi S, Yamada A, Morita S, Mizunoya Y (1981) Absence|of synergistic toxicity of two food additives, anhydrous|sodium sulfite and sodium propionate, in rats treated orally|for 3 months. (Studies on synergistic toxicity of food|additives. I). J Food Hyg Soc Japan 22: 351-365
Huls AG (1994). Final Report DDA 85. Determination of the|biodegradability of DYNASYLAN DAMO-T in DOC-DIE AWAY TEST.|November 3, 1994.
Short-term toxicity to aquatic invertebrates, IUC4#12/Ch.4.2
Biosafety Research Center, Tanaka R, Moriyama T, Iga T,|Yamamoto Sh (2001) Preliminary reproduction toxicity|screening test of|N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine by oral|administration in rats. Tox Testing Rep Environ Chemicals 8|(2): 795-807
Strobel R, Lambert AH (1998): Isophytol (Ro 02-8825/000):|28-Day oral (gavage) toxicity study in the rat with a 14-day|treatment-free period (Study 962I96; Quintiles Project no.|HRE/39/C). Study performed at Quintiles England Ltd,|Ledbury, UK, on behalf of F.Hoffmann-La Roche Ltd, Basle,|unpublished.
Method: other: pretest to 28-day OECD 407 subchronic study
Kozerski, G., Ziemelis, M., Gallavan, R. "Determination of|3-glycidoxypropyl-trimethoxysilane Hydrolysis Kinetics Using|Liquid Chromatography and Inductively Coupled Plasma|Emission Spectroscopy"; final report to the Silicones|Environmental Health and Safety Council of North America|(SEHSC); SEHSC: Reston, VA, 2000.
Yam, J., Reer, P. J. and Bruce, R.D. Comparison of the up and down method and the fixed-dose procedure for acute oral toxicity testing. Food. Chem. Toxicol. 29, 259-263, 1991
Stumm-Tegethoff BFA (1969). Formaldehyde-induced mutations|in Drosophila melanogaster in dependence of the presence of|acids. Theor Appl Genetics 39, 330-334.
Monsanto (1992) Toxicology Profile Santoflex 13 Antiozonant|(unpublished data compilation)
OHMTADS Data Bank (1989) in: Solvay and Cie, unpublished,|file no.: 372 (1991).
Foussereau, J, et al (1983) Allergy to MBT and its derivatives.|Contact Dermatitis, 9, p514-516
Bryant PJ, Sang JH (1968): Physiological genetics of|melanotic tumors in Drosophila melanogaster. VI. The|tumorigenic effects of juvenile hormone-like substances.|Genetics 62: 321-336.
Mitchell AD (1925). The hydrolytic decomposition of|phosphorus trichloride. J. Chem. Soc. 127, 336-342.
BASF AG, 2003, Department of Product safety, unpublished|calculation, SRC BCFWIN v2.14, 25 June 2003
Method: other: calculated via SRC BCFWIN v2.14
BASF AG, department of toxicology, Pruefung der akuten|oralen Toxizitaet an der Ratte (englisch), unpublished|results (85/209), 10-07-85
Henninghausen G, Tiefenbach B, Dietrich C (1974)|Untersuchungen über toxikologische und pharmakologische|Eigenschaften von Chlorcholinchlorid und N,N-Dimethyl-|(2-bromethyl)-hydraziniumbromid. Acta Biol Med Germ 33:|89-98
Placke M, Persing R, Cox T, Griffis L, Bus J and Bird M.|Inhalation oncogenicity study of isoprene in B6C3F1 mice.|(Study not yet published.)
Method: other (calculated): KOWWIN v.1.66
Nair RS, Johannsen FR, Schroeder RE (1985) Evaluation of|Teratogenic Potential of Para-Nitroaniline and|Para-Nitrochlorobenzene in Rats and Rabbits. In: Toxicity of|Nitroaromatic Compounds (Rickert, D.E. ed.): pp. 61-85,|Hemisphere Publishing Corporation, New York
Method: other: pilot study to set dose levels, 5 mated rats/group, the rats were sacrified on d 20 of gestation
BASF AG, Experimental Toxicology and Ecology, unpublished study, Isobutylacrylat - Determination of the inhibition of the oxygen consumption by activated slude in the activated sludge respiration inhibition test, 01/0366/08/1, 2 October 2001
Method: other (calculated): SRC-MPBPWIN v1.40
Sumitomo Chemical Co. data, September 24, 1981 (reported to Bayer AG) as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Genetic toxicity in vitro, IUC4#60/Ch.5.5
BASF AG, Laboratory of Ecology, 1988, Pruefbericht ueber|eine Untersuchung der Wirkung von beta-Ionon auf die|Atmungsaktivitaet von Belebtschlamm, No. 01.0429,|unpublished study, 1988
Method: other: ISO/DIS 8192, Part B: Water quality - Test for inhibition of oxygen consumption of activated sludge. Draft, 1984
Dill, D.C., Davis, J.W., (1997). Environmental assessment of the Dowanol glycol ethers P-series product family. Dow Chemical Company Study ID ES-3186. August 12, 1997. Unpublished Report.
Chemfirst Inc (1997) Delayed contact hypersensitivity study|in guinea pigs (Buehler Technique), paranitrotoluene (at the|request of First Mississippi Corporation), January 14, 1997|NTIS/OTS 0559506
BASF AG, Department of Product Safety, unpublished study,|00/0598/50/2, February 2003
Biodegradation in water: screening tests, IUC4#19/Ch.3.5
FMC Corp. data (1976), EPA OTS 86860000116 cited in BIBRA|Toxicity Profile (1991)
Haskell laboratory, Inhalation median lethal|concentration toxicity study with orthochloronitrobenzene in|rats, at the request of Dup0nt de Nemour, EPA OTS 0540655,|1992
Method: other: 10 male rats/conc., head-only exposure, 6 conc., heated vapour was diluted with humidified and O2-enriched air and thus converted to a mixture of vapour and liquid aerosol, post exposure observation time: 14 d
BASF (1988) Toxicity to Pseudomonas putida (0040/88). BASF|AG, Department of Ecology, 01.03.1988 (unpublished data)
Method: other: DIN 38412, part 8, Determination of the inhibitory effect on the cell multiplication
Grigg, G.W. et al.: J. Bacteriol. 107 (3), 599-609 (1971);|cited in: RIFM database, location no. 12050
Genetic toxicity in vitro, IUC4#77/Ch.5.5
Dube, Shukla, Tribathi (1988) Pesticides 22(3):11-12.
Toxicity to microorganisms, IUC4#8/Ch.4.4
BASF AG, Department of Toxicology, unpublished results,|Proj. No. 36I0794/87088, 03 Jan. 1989
Method: other: based on OECD guideline 412
Method: other: 2 rabbits, 500 mg/rabbit, to the hairless side of the ear, kept in place by adhesive plaster, time of reading when the wrapping was removed, 24 hrs and daily up to 7 days
Best EPH, Miller JL, and Larson SL (2001). Tolerance towards|explosives, and explosives removal from groundwater in|treatment wetland mesocosms. Water Sci. Technol. 44 (11-12),|515-521.
Biodegradation in water and sediment: simulation tests, IUC4#180/Ch.3.5
BASF AG (2007). Expert judgement: Formic acid 99-100 % -|materials compatibility and odor. BASF AG, Department|E-CZS/PC, 12 July 2007 (unpublished).
Appearance/physical state/colour, IUC4#8/Ch.1.1.1
ALLIED CHEM CORP (1979) SHORT-TERM MUTAGENICITY AND CELL TRANSFORMATION SCREENING OF TOLUENE DIAMINE IV EFFECT OF FOUR TOLUENE DIAMINE ISOMERS ON MURINE TESTICULAR DNA SYNTHESIS. U.S. EPA/OPTS Public Files Fiche No. 0206440 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com)
BASF AG (1969) Toxicity of choline chloride 50% powder; eye|irritation. Department of Toxicology, skin laboratory,|unpublished results, Study No. XIX/271, 28. 07.1969
Adema, D.M.M. (1988) Aminoethylpiperazine: acute toxicity|evaluation with Daphnia magna. Unpublished Dow Chemical|Company report.
Ishidate M. Jr. et al.: Fd. Chem. Toxic., 22, 623-636,(1984)
Brasch, J. et al., Dermatosen 41, 71-76 (1993)
Bauer, H. & Burschkies, K.: Sättigungsdrucke einiger Senföle|und Sulfide. Berichte d. Deutschen Chem. Gesellschaft/A 68,|1238-1243 (1935)
DuPont (1956). Toxicity studies of dichlorobutene products. Haskell Laboratory, Medical Research Project MR-195 / Report No. 44-56 dating from 12/03/1956 (NTIS OTS 555504).
Salmonella typhimrium TA98, TA100, TA1535, TA1537, TA102
BASF AG, 1977, Analytical Laboratory, Dampfdruckmessung von|2-Methylbuten-2-ol-1 und 2-Methylhepten-2-on-6, unpublished|study, BRU 77.8, 21 Jan. 1977
Method: other (measured): method unknown
Millemann et al. (1984): Trans. Am. Fish Soc. 113(1), 74-85
Method: other (calculation): QSAR Estimation Method: PCKOCWIN v. 1.66 (2000)
BASF AG, Toxicology Research Department, study report dated |21 Jan. 1980
Method: other: Bioaccumualtion to Crassius auratus in continuous-flow
Dow Chemical Company (2005). EH&S Toxicology & Environmental|Research & Consulting, test data communicated to BASF AG on|27 Oct 2004 and specified on 11 Jan 2005, unpublished.
Method: other: acute toxicity test according to Dow SOP
CERI (2004). Report of phicical-chemical properties of|Tetrahydrofurfuryl alcohol: CAS No. 97-99-4. Test Number|805258. Unpublished data.
Mapes, D.A., 1972. Solubility of Methyl Bromide in Water at|20ºC. Unpublished report from Dow Analytical Laboratories.|Report 40-844.
Method: other: No specific protocol guideline number was included with the report although methodology is described.
Huyskens P, Mullens J, Gomez A, and Tack J (1975).|Solubility of alcohols, phenols and amines in water. Bull.|Soc. Chim. Belg. 84 (3), 253-262.
Schultz TW (1999) Structure-Toxicity Relationships for|Benzenes evaluated with Tetrahymena pyriformis. Chem Res|Toxicol 12: 1262 - 1267
Rop, D.A. (1979) Acute Inhalation LC50 Determination in Rats -|4 Hours - 14 Days on Dow Corning TX-1747 (Cut 1). Mattawan,|Mich.: IRDC, Dec 1979. Cited in AIHAJ (1997) Workplace|Environmental Exposure Level Guides: Trimethoxysilane (1997)
EPA OTS 798.5100 (Escherichia coli WP2 and WP2 UVRA Reverse Mutation Test)
BioDynamics Inc. (1990). Dermal irritation study - C-1261. |Unpublished study report to project No. 5071-88, dated|February 8, 1990. Sponsored by Hoechst Celanese Corporation,|Somerville, New Jersey.
Bosma TNP, Ballemans EMW, Hoekstra NK, te Welscher RAG,|Smeek JGMM, Schraa G, Zehnder AJB (1996) Biotransformation|of Organics in Soil Columns and in Infiltration Area. Ground|Water 34 (1): 49 - 56
Method: other: Laboratory column experiment with river sediment
Biodegradation in water: screening tests, IUC4#95/Ch.3.5
Thompson CZ, Hill LE, Epp JK, Probst GS (1983) The Induction|of Bacterial Mutation and Hepatocyte Unsheduled DNA|Synthesis by Monosubstituted Anilines. Environ Mutagen 5:|803-811
Method: other: preparation of hepatocytes: according to Williams et al. 1977, In Vitro 13, 809-817; autoradiographic assay according to Probst et al. 1981, Environ. Mutagen 3, 11-32
BASF AG, Technische Entwicklung Verfahrenstechnik,|Stoffwertmessungen am System 3-Methyl-3-buten-1-al (I-MBA),|3-Methyl-2-buten1-al (MBA), Wasser und Ameisensäure,|unpublished study, 186.0610.1, 15 July 1986 (Sub-Report 10|Oct. 1985)
Method: other (measured): dynamic with nitrogen
Sax and Lewis, Sr. 1989. Dangerous Properties of Industrial|Materials. 7th edition, p. 2020. Van Nostrand Reinhold.
Loveday, K. et al. (1990) Environ. Mol. Mutagen., 16, 272-303.
ExxonMobil Biomedical Sciences, Inc. (2004). Ready|Biodegradability, Manometric Respirometry. Study #177294A.
BASF AG, 2003, Department of Product Safety, unpublished|calculation, SRC KOWWIN v1.66, 25 June 2003
Method: other (calculated): via SRC KOWWIN v1.66
Nagahara N., Modification by Glycerol of the Initial process|of Pulmonary Tumorigenesis Induced by 4-Nitroquinoline|1-Oxide in Mice, Yokohama Med Bull, 38(5-6): 141-150 (112).
CERI (2004). Boiling point study of Tetrahydrofurfuryl|alcohol: CAS No. 97-99-4. Test Number 805282. Unpublished|data.
NIOSH (National Institute for Occupational Safety and|Health), Washington, DC:|http://www.cdc.gov/niosh/ipcs/icstart.html (01 Jun 2002).
Dow Corning Corporation Internal Report Number|1981-I0005-841
BASF AG, Department of Toxicology, unpublished data,|(XXV/436), 10 Sept. 1976a
Developmental toxicity / teratogenicity, IUC4#12/Ch.5.8.2
Schütz E., Effects of organic liquids on the skin,|Arzneimittel-Forsch. 10, 1027-29, 1960 (HSE translation)
Velsicol Chem. Corp. (1980) Benzotrichlorid: three-week|dermal toxicity study in rabbits. Report No 163-673. 4 April|1980. As submitted to U.S. EPA under TSCA on 20 Nov 1980,|U.S. EPA TSCA FYI-OTS-1180-0107 IN.
Trenel J and Kuhn R (1982) Bewertung Wassergefahrdender|Stoffe im Hinblick auf Lagerung, Umschlag und Transport,|Umweltforschungsplan des Bundesministers des Innern (OECD|Data File)
Hoechst AG, Unpublished reports. Ber. 90, 1295, 1991
Ashby, J. and Lefevre, P. in: Gibson, J.E. (ed.):|"Formaldehyde toxicity", Hemisphere Publishing Corp.,|Washington, New York, London (1983), chapter 9, pp. 85-97, No information
Gilbert P, Saint-Ruf G, Poncelet F, Mercier M (1980) Genetic|effects of chlorinated anilines and azobenzenes on|Salmonella typhimurium. Arch Environ Contam Toxicol 9,|533-541
Method: other: according to Green MHL et al. (1977) Mutat Res 48, 287-294: bacterial fluctuation test, incubation 72 hours, solvent: ethanol abs., triplicates
Izmerov, N.F., et al. (1982) Toxicometric Parameters of Industrial|Toxic Chemicals under Single Exposure, Centre of|International Projects, GKNT, Moscow.
San, H.C. and Clarke, J.J. (1997), "In Vitro Mammalian Cell|Gene Mutation Test with an Independent Repeat Assay",|Microbiological Associates Inc., Study No. G96CJ23.782001
Elf Atochem UK (1992). Safety Data Sheet. November 1992.
Springborn Smithers Laboratories (2004) Resorcinol - Full Life Cycle Toxicity Test with Water Fleas, Daphnia magna Under Flow-through Conditions. Lab ID Number: Study No. 13048.6404.
Comet assay - human lung carcinoma epithelial A549 cells, V79 Chinese hamster fibroblasts, and human peripheral blood cells. Micronucleus assay - V79 Chinese hamster fibroblasts, HPRT-gene mutation assay - V79 Chinese hamster fibroblasts.
SafePharm Laboratories (2007) 3-Mercaptopropionic |acid: Chromosome Aberration Test in Human Lymphocytes |In Vitro. SPL Project Number 1158/0051
Ishidate, M., Jr., Sofumi, T., Yoshikawa, K., Hayashi, M.,|Nohmi, T., Sawada, M. and Matsuoka, A. (1984) Primary|mutagenicity screening of food additives currently used in|Japan. Fd Chem. Toxic., 22, 623-636.
Tremain, S.P. (2004), "E-Caprolactone: Determination of|vapour pressure", SafePharm Laboratories Ltd Project Number|1524/004
Repeated dose toxicity: inhalation, IUC4#52/Ch.5.4
Freitag D, Lay JP, and Korte F (1984). Environmental Hazard|Profile - Test Results as related to Structures and|Translation into the Environment. In: KLE Kaiser (ed.). QSAR|in Environmental Toxicology. Proceedings of the Workshop on|Quantitative Structure-Activity Relationships (QSAR) in|Environmental Toxicology, Macmaster University, Hamilton,|Ontario, Canada, August 16-18, 1983. D. Reidel Publ.,|Dordrecht, 111-136.
BASF AG, personal communication department CAD, 10.06.2003
BASF Aktiengesellschaft. 2000. Determination of the Biodegradability of TZ 03498 in the Manometric Respirometry Test. Project No. 99/0606/26/1. Ludwigshafen, Germany. 06.11.00.
Method: other: Directive 92/69/EEC, C.4-D [corresponds to OECD Guideline 301 F (1993) and ISO Standard 9408 (1999)]
Hoechst AG (1989): Product Information beta Hydroxynaphthoic|acid, Sales Department Fine Chemicals
Keetelaar-Jansen, W.A.J. and Thus, J. (1993), "Determination|of the biodegradability of epsilon-caprolactone in a|modified Sturm test", Solvay Duphar Int. Doc. No. 56835/2/93
Infracor Degussa Group (1993) Final Report DK 565: DYNASYLAN|GLYMO Determination of the immobilisation of Daphnia magna|STRAUS (Acute Immobilisation Test) (English translation of|the German Final Report dated 26.07.1993). Degussa AG-Nr.:|93-0203-DGO.
Hamasaki, T., S. Takahiko, H. Nagase, and H. Kito. 1993. The mutagenicity of organotin compounds as environmental pollutants. Mutation Res. 300:265-271.
Bushy Run Research Center (1988) Trimethoxysilane: Acute|Vapor Inhalation Toxicity Study in Rats. Project Report|50-147
Vedula, U. et al., Unpublished report of The Dow Chemical|Company (inhalation teratology test) (1996)
BASF AG, 2000, Safety Data Sheet, Choline Chloride powder|60%, 20 March 2000
Lonza AG, unpublished report, 1990, Ready Biodegradability, Lonza Report No. 1543
EU Method C.4-B (Determination of the "Ready" Biodegradability - Modified OECD Screening Test)
Chemicals Inspection and Testing Institute (1992) Biodegradation and Bioaccumulation Data of Existing Chemicals based on the CSCL Japan. ISBN 4-89074-101-1
Method: other: carcinogenicity after repeated inhalation exposure
Schering AG. 1989. Determination of the Water Solubility of Di-n-Octyltin Dichloride. Report No. VE 07/89. 11.04.1989.
Allyl Alcohol Consortium (2005b) BCFWIN v2.14 Calculations,|Unpublished Data
Hatch GG, Anderson TM (1985) Assays for enhanced DNA viral|transformation of primary Syrian hamster embryo cells. Prog|Mut Res 5: 629-638
Method: other: Adenovirus (SA7) transformation assay as prescribed by Casto, B.C. (1973): Progr. Esp. Tumor Res. 18, 166-198
Lyman, WJ, WF Reehl, and DH Rosenblatt (1982) Handbook of|Chemical Property Estimation Methods. McGraw-Hill Book|Company, New York, NY, USA.
Japanese Ministry of the Environment, Government of Japan|(2001)
Casanova, M. et al.: Fund. Appl. Toxicol. 17, 409-428 (1991), No information
Genetic toxicity in vivo, IUC4#171/Ch.5.6
Blum, M.S. and J.J. Pratt, Jr. 1960. Relations between structure and insecticidal activity of some organotin compounds. Journal of Economic Entomology. 53:445-448.
Bayer AG (1976). Biodegradability of Benzotrichloride.|Unpublished Report, written 2001-02-28.
Genetic toxicity in vitro, IUC4#58/Ch.5.5
Pharmakon Research Int., Inc., Micronucleus Test (MNT) OECD,|PH 309A-UN-001-84, Flexzone 7F, unpublished study of|Uniroyal Chemical Co., 1984
Report No. A79-146. May 25, 1979. Toxicity Data Report. Animal Industry R/D, Agricultural Division, American Cyanamid Co. P.O. Box 400, Princeton, NJ 08540
Thornton, M. et al. (1989): Carcinogenesis 10, 407 - 410
Ford GP, Butler WH, Hooson S, Gaunt IF and Hawkins IF|(1983). The short-term (90 days) toxicity of alpha- and|beta-ionone in rats. Unpublished report from the British|Industrial Biological Research Association, cited in WHO|Food additives Series No. 19, 72-74, March 1984
Weast RC and Grasselli JG (1989). CRC Handbook of Data on|Organic Compounds, 2nd Edition. CRC Press, Inc. Boca Raton,|FL, 1
Hawley's Condensed Chemical Dictionary (2002). 14th edition,|John Wiley & Sons, Inc., New York, USA.
Elvers, B., Hawkins, S., Russey, W., Schulz, G. (eds)(1999).|Ullmann's Encyclopedia of Industrial Chemistry. 5th edn. Vol|A22, pp. 33-103. VCH Publishers Inc.
Olah GA and Fung AP (1979). Synthetic methods and reactions;|67. One-step conversion of alicyclic ketones into lactams|with hydroxylamine-O-sulfonic acid/formic acid. Synthesis|1979 (7), 537-538
Biodegradation in water: screening tests, IUC4#17/Ch.3.5
BUA (Advisory Committee on Existing Chemicals of|Environmental Relevance) (1991). BUA Report No. 72.|Benzotrichloride. Stuttgart, S. Hirzel Verlag.
Wilde et al. (1983): Comparison of chlorine and chlorine|dioxide toxicity to fathead minnows and bluegill. Water Res,|17, 1327-31.
Method: other: according to EPA guidelines
Air Products & Chemicals Inc., Allentown PA, USA|(1992) zitiert in HEDSET von Anchor Chemical (UK)|Ltd., 27.04.94
Toxicity to microorganisms, IUC4#50/Ch.4.4
BASF AG, Product Safety, 3-Methyl-2-buten-1-al (Prenal) -|one-generation reproduction toxicity study in Wistar rats,|continuous administration in the drinking water, unpublished|report, project no. 76R0680/00120, 18 Nov. 2002
Franzen R (1995) Synthesis and analyses of mutagenic|chlorohydroxyfuranones and related compounds: by-products of|chlorine disinfection of drinking water and of chlorine|bleaching of pulp. Acta Academiae Aboensis Ser. B 55: 1-52
Method: other: according to Ames B.N. et al.: Mut. Res., 31, 347-364 (1975)
Kleniewska D (1975) Studies on hypersensitivity to|"para-group". Berufsdermatosen 23, 31-36
Novoselova, NV et al. (1985). Specific Heat and Thermodynamic Functions of 4,4'-Dihydroxydiphenyl-2,2-propane, 4,4'-Dichlorodiphenylsulphone, and Polysulphone. Russion Journal of Physical Chemistry, 59 (3): 350-352.
Method: other (calculated): CLOGP Program
Daubert, T.E., R.P. Danner(1989). Physical and Thermodynamic|Properties of Pure Chemicals Data Compilation. Washington,|D.C.: Taylor and Francis
BioReliance (1999). Study number G98AY06.123, February 2,|1999.
Seiler JP (1977) Inhibition of testicular DNA synthesis by|chemical mutagens and carcinogens. Mutat Res 46: 305-310
Method: other: according to Friedman and Staub, 1976, Mutation Res. 37, 67-76, see also freetext TC
Vardiabasis, N.B., Teplitz, R.L., Chernoff, G.F. and Seecof, R.L.; Detection of Teratogens in the Drosophila Embryonic Cell Culture Test. Teratology. 28, 109-122, 1983
Salmonella typhimurium TA 98, 100, 1530, 1535, 1538
Dow Chemical Company (2001). Aminoethylethanolamine (AEEA),|technical leaflet, Midland, Michigan.
Grote A, Hamburger B, Kanne R, Olivier M (1983)|Biodegradation of 3,4-Dichloro-1-Nitrobenzene under the|Conditions of Industrial Waste Water Treatment Plants. Vom|Wasser 60: 191 - 196
Method: other: Simulation of an industrial waste water treatment plant
Ross R.H. et al (1978), "Environmental and health aspects of|selected organohalide compounds : an information overview",|Oak Ridge National Laboratory, EIS-105, Jul.
Phototransformation in air, IUC4#4/Ch.3.1.1
Hüls AG (1988c). Internal Letter "Toxikologisches Screening|für Micronucleus-Test, Test No. 1354" reporting result of|screening study (unpublished).
Askonas CF and Daubert TE: Vapor Pressure Determination of|Eight Oxygenated Compounds. J. Am. Chem. Engineering Data|33, 225-229 (1988)
Chemicals Evaluaiton and Research Institute, Japan
Dow Corning Corporation (1982) Dow Corning Corporation|Internal Report No. 1982-I0005-0989
Toxicity to microorganisms, IUC4#54/Ch.4.4
Handbook of Environ. Data on Organic Chemicals 2nd edition,|Verschueren, K. (ed.) Van Nostrand Reinhold Co., New York,|329 (1983)
Chemische Werke Hüls, Verfahrenstechnik (1964). Vapour|pressure curve "Laurinlactam" (unpublished)
Method: other (calculated): Extrapolation from measured data
Method: other: Pseudomonas-Atmungs-Hemmtest, DIN 38412 Teil 27, in Vorber., Bestimmung der Hemmwirkung von Abwasser auf die Sauerstoffzehrung von Pseudomonas putida (effect of substances in water on the oxygen consumption of P. putida)
El-Ziney MG, De Meyer H, and Debevere JM (1997). Growth and|survival kinetics of Yersinia enterocolitica IP 383 O:9 as|affected by equimolar concentrations of undissociated|short-chain organic acids. International Journal of Food|Microbiology 34, 233-247.
MPBPWIN version 1.40 (US EPA EPIWIN Suite Software)
Method: other (calculated): MPBPWIN version 1.40 (Model)
Canton, J.H., Wegman, R.C.C., Mathijssen-Spickman, E.A.M.|and Wammes, J.Y., (1980). Hydrobiological toxicological|research with methyl bromide. National Instititute of Public|Health and Environmental Hygiene, Report No. 105/80
Ministry of Health & Welfare, Japan (1996a): Toxicity|Testing Reports of Environmental Chemicals, vol.4 p99-106,|"Twenty-eight-day Repeat Dose Oral Toxicity Test of|2-Amino-5-methylbenzenesulfonic acid in Rats".
Method: other: preliminary examination of OECD TG407
CERI (2004). Hydrolysis study of Tetrahydrofurfuryl alcohol:|CAS No. 97-99-4. Test Number 805286. Unpublished data.
Suzuki, Y. and Kimura, H.: Aichiken Suisan Shikenja Gyomu|Hokoku, 55-58 (1989);|cited in: IPCS Environ. Health Crit. 89, (1989), No information
Ward, T.J., P.L. Kowalski, and R.L. Boeri. 1995. Acute toxicity of the water accommodated fraction (WAF) of alkyltin MA to the fathead minnow, Pimephales promelas. T.R. Wilbury Laboratories, Inc. T.R. Wilbury Study Number 861-MO.
Dalbey, W.E. et al.: Toxicology 24, 9-14 (1982), No information
Ciba-Geigy Ltd., Report on the test for inhibitory|concentration of TK 10044 on aerobic bacteria, Project No.|884366, 14.11.1988.
Bolt, H.M. and Gansewendt, B.: Crit. Rev. Toxicol. 23(3):|237-253 (1993).
Method: other: in general conformance with OECD 453
SCF: First report of the Scientific Committee for Food on|certain additives used in the manufacture of plastic|materials intended to come into contact with foodstuffs.,|Reports of the Scientific Committee for Food (33rd series).,|European Commission, Luxembourg, (1995)
Ito, N. et al., Prog. Experiment. Tumor Res. Vol. 33, 41-57,|S. Karger AG, Basel (1991)
Method: other: Medium term bioassay for carcinogens
Hermens J, Busser F, Leeuwanch P, Musch A (1985). Quantitative correlation studies between the acute lethal toxicity of 15 organic halides to the guppy (Poecilla reticulata) and chemical reactivity towards 4-nitrobenzylpyridine. Toxicol. Environ. Chem. 9 (3), 219-236.
Method: other: test procedure according to Koenemann H (1981). Toxicology 19, 209-221.
Zacherl, B. and Amberger, A. (1984). VDLUFA-Schriftenreihe|11, 55-63
Veith GD, Macek KJ, Petrocelli SR and Carroll J (1980). An|evaluation of using partition coefficients and water|solubility to estimate bioconcentration factors for organic|chemicals in fish, in: Aquatic Toxicology, Am. Soc. Test.|Mat. Spec. Tech. Publ. 707; Eaton JG, Parrish PR and|Hendricks AC (Eds.), 116-129.
Method: other (measured): Flask-shaking Method
National Toxicology Program (NTP) (1995) In vivo Bone Marrow Micronucleus Assay Tests 1 and Repeat In vivo Bone Marrow Micronucleus Assay Test 2. Contract Number: N-01-ES-15312 submitted by Novel Pharamceutical, Inc. Durham, NC.
Kühn, Birett: Merkblätter für gefährliche Arbeitsstoffe,|10th Ed. 1992, Ecomed Verlag, Stand: 1. April 1994.
Reported by Kennedy G.L. (1986) CRC Crit. Rev. Toxicol.,|17:129-182 from Kelly D.P. et al. (1984). Toxicologist,|4:65.
Dearman R.J. & Kimber I., Central Toxicology Laboratory|Alderley Park Macclesfield, Cheshire UK. Assessment of the|Allergenic and Respiratory Sensitizing Potential of|Ethyleneamines and Ethanolamines. Unpublished report No.|CTL/L/8918, 18 Dec 2001, sponsored by The Dow Chemical Co.,|Midland, USA
Method: other: similar to OECD 429 (draft)
Bayer AG 1994, Internal Study, Chronic toxicity of BHT to|daphnia magna; test report 466 A/94
Method: other: OECD Guide-line 202, part 2 "Daphnia sp., Reproduction Test" draft 1993
Zhang C, Daprato RC, Nishino SF, Spain JC, Hughes JB (2001).|Remediation of dinitrotoluene contaminated soils from former|ammunition plants: soil washing efficiency and effective|process monitoring in bioslurry reactors. J. Hazard. Mater.|B87, 139-154.
Method: other: Sequential reactor degradation experiments
MITI; Japan, Biodegradation and Bioaccumulation Data of Existing Chemicals based on the CSCL Japan(Japan Chemical Industry Ecology-Toxicity & Information Center), p.3-21, 1992
Merck, study report no. 40/10/95, Expt. T13812, 16 Jun. 1997|(sponsored by BG Chemie)
Biodegradation in water: screening tests, IUC4#69/Ch.3.5
2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-methyl-7-oxo-8-oxa-3 ,5-dithia-4-stannatetradecanoate (IUC4 DSN 35)
Draize JH, Alvarez E, Whitesell MF, Woodard G, Hagen EC. 1948. Toxicological investigations of compounds proposed for use as insect repellants. J Pharmacol Exp Ther 43:26.
Daniel FB, Olson GR, Stober JA (1991): Induction of|gastrointestinal tract nuclear anomalies in B6C3F1 mice by|3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and|3,4-(dichloro)-5-hydroxy-2(5H)-furanone, mutagenic|byproducts of chlorine disinfection. Environ Mol Mutagen 17:|32-39
Method: other: Assay for micronuclei in tissues of GI tract
Bringmann,G., Kuehn,R., Gesundheits-Ingenieur 81(11),|337-339, 1960, No information
Defitraces (2003) Report No. 02-902003-059. Boiling point of|IOTG. April 3, 2003.
Degussa AG: Subchronic (13-week) inhalation toxicity study|of aerosols of AEROSIL 200, AEROSIL R974, SIPERNAT 22 and|quartz in rats. Unpublished report: Degussa AG - US-IT-No.|87-0004-DGT, TNO, 1987
Method: other: acc. to OECD Guide-line 413, see Method
Method: other: OECD Guide-line 414 "Teratogenicity" (see chapter 5.8.2)
Carrington, C.D. Lapadula, D.M., Othman, M., Farr, C., Nair, R.S., Johannsen, F., and Abou-Donia, M.B. (1990).|Assessment of delayed neurotoxicity of tributylphosphate,|tributoxyethylphosphate, and dibutylphenylphosphate.,|Toxicol. Ind. Health 6, 415-423. and Duke University|Medical Center. Studies in the Delayed Toxicity of TBP. Monsanto Study DU-84-433. (1984)
Ulitzur, S.: Trends Analyt. Chem. 1, 329-333 (1982)
Genetic toxicity in vitro, IUC4#48/Ch.5.5
Zwolinski, BJ and Wilhoit, RC (1971) Handbook of Vapor|Pressures and Heats of Vaporization of Hydrocarbons and|Related Compounds. API44-TRC101. Thermodynamics Research|Center, College Station, TX, USA.
NTP (National Center for Toxicologial Research): 90 Day|Subchronic Report On Caffeine in B6C3F1 Mice, Final Report,|NCTR Techn. Rep. for Expt. No. 384 (NTP Expt. No. 05011-04)|(1983)
Method: other: Alkaline filter elution assay
Genetic toxicity in vivo, IUC4#87/Ch.5.6
Graham, R.C. et al.: Toxicity Summary o-Chloronitrobenzene.|Unpublished summary by du Pont provided by Dastur (1983):|cited in Chemical Hazard Information Profile Draft report|2-Chloronitrobenzene, June 13, 1983, Office of Toxic Sub-|stances, EPA, USA
BASF (1964) Skin irritation in rabbits (XIV/97;|XIV/182-184). BASF AG, Department of Toxicology, 13.08.1964|(unpublished data)
Ministry of Health and Welfare (1999) Single dose oral|toxicity test of 1-chloro-2 (chloromethyl)benzene in rats.|Japan Toxicity Testing Reports of Environmental Chemicals,|7, 489-491.
Chang and Barrow (1982), cited in Bos P.M.J. et al., Crit.|Rev. Toxicol., 21, 423-450 (1992)
Acute toxicity: inhalation, IUC4#17/Ch.5.1.2
Schlagbauer and Henschler (1967), Int Arch Gewerbepath|Gewerbehyg, 23, 91-98.
Dixon D and Rissmann E (1985). Physical-chemical properties|and categorization of RCRA wastes according to volatility.|Versar Incorporated, Springfield, VA, prepared for U.S. EPA,|Research Triangle Park, NC, USA.
Degussa AG (2002). Degussa lauryl lactam exposure|questionnaire (unpublished)
fetal Chinese hamster cell line V79 (lung tissue)
Gigiena i Sanitariya. (V/O Mezhdunarodnaya Kniga 113095|Moscow, USSR) (1974). V.1, 39(4), 86-89.
Parker D. und Turk J.L.: Cont. Dermat. 9, 55-60, (1983)
Gubser H (1969) Probleme bei der Reinigung von Chemieabody weightassern. Gas-Wasser-Abwasser 49:175-181.
Method: other: Modified German Detergentientest
EPA OPPTS 870.5385 (In Vivo Mammalian Cytogenetic Tests: Bone Marrow Chromosomal Analysis)
Stich HF, Rosin MP, Wu CH, Powrie WD (1981) The action of transition metals on the genotoxicity of simple phenols, phenolic acids and cinnamic acids. Cancer Letters 14:251-260.
Debnath et al., 1992, cited in SRC-KOWWIN Program (v1.65)
Byshovets TF, Borilyak LR, Kosachuk SY, Pisko GT, Tolstopyotova G, Perfilo AV (1983). Study of the indirect results of the effect of certain diphenyl derivatives. Gig Sanit (4) 19-20, 1983.
Reed GA, Jones BC (1996) Enhancement of benzo[a]pyrene diol|epoxide mutagenicity by sulfite in a mammalian test system. |Carcinogenesis 17: 1063-1068
MHLW(Ministry of Health, Labour and Welfare), Japan(2004),|Toxicity Testing Reports of Environmental Chemicals, 11,|155-194
Amoco Chemicals Corporation (1987) Acute Inhalation Toxicity|study of Purified Terephthalic Acid in Rats. Conducted by|IIT Research Institute. IITRI Study #1158
Klimmer, O.R. 1971. Pharmakologisches Institut der Rheinischen Friedrich-Wilhelms-Universität. Prüfungsbericht über die akuten Fütterungsversuche mit Di-n-Butyl-Zinndichlorid an Ratten. 19.11.1971.
Reported in AIDA (13/11/92)-Alstoff Information Data Bank:|Cit. in BASF AG Analytical Laboratory-Unpublished Data from|Rekker R.F. (1988). The hydrophobic fragmental constant.|Elsevier, Amsterdam
Chang, J.C.F. and Barrow, C.S.: Toxicol. Appl. Pharmacol.|76, 319-327 (1984), No information
Biodegradation and Bioaccumulation Data of Existing Chemicals Based on the CSCL Japan, Compiled under the Supervision of Chemical Products Safety Division, Basic Industries Bureau MITI, Ed. by CITI, October 1992. Published by Japan Chemical Industry Ecology-Toxicology & Information Center
Method: other: Japanese Industrial Standard (JIS K 0102-1986-71) "Testing methods for industrial waste water"
Short-term toxicity to fish, IUC4#170/Ch.4.1
Dow Corning Corporation Internal Report Number|1981-I0065-4122-03
Eastman Kodak Co. (1986) Letter from Eastman Kodak Company|to USEPA submitting enclosed material safety data sheet and|toxicity report on 1,2-Dichloro-4-nitrobenzene with|attachments (OTS05333685, 86-920000019)
Method: other: no further information available
Portmann JE and Wilson KW (1971). The Toxicity of 140|Substances to the Brown Shrimp and Other Marine Animals.|Shellfish Information Leaflet No.22 (2nd Ed.), Ministry of|Agric. Fish. Food, Fish. Lab. Burnham-on-Crouch, Essex, and|Fish Exp. Station Conway, North Wales, 12
In vitro microbial mutagenicity studies of ethane,|1-chloro-1,2,2,2-tetrafluoro. Haskell Laboratory Report No|349-76, May 1976. A two page summary report of study|performed by Haskell Laboratories.
Serota D., 1990, 28-day oral toxicity study in rats, compound B10., Lorillard Inc.
Human embryonic intestinal cell (Flow 11000)
Method: other: Estimated using MBPBPWIN (ver. 1.40)
M&T Chemicals, Inc. 1988. A Four-Week Inhalation Study with Monobutyltin Trichloride in the Rat with a Recovery Period. Project No. 85-7838. Final Report (revised). Study conducted by Bio/dynamics Inc.
United States Testing Company,Inc., Toxicological and skin|corrosion testing of selected hazardous materials, Report|No. DOT/MBT/OHMO-76/2, april 1976, PB-264-975 (at the|request of U.S. Department of Transportation, Office of|Hazardous Materials Operations)
Method: other: 5 rabbits/dose, trunks were clipped free of hair, 3 doses (warm to melting point), exposure time 24 h (rabbits immobilized during exposure), then rinsing and wiping dry, observation time: 14 d
Clariant GmbH (1999): Calculation of pKa (pKalc 3.2|Compudrug)
Industrial Bio-test Laboratories, Inc Data Sheets (1810|Frontage Rd. Northbrook, IL 6002). (Via RTECS).
Heidelberger, C. et al.: Mutat. Res. 114, 283-385 (1983)
Robbiano L, Carrozzino R, Bacigalupo M, Corbu C, Brambilla G|(2002) Correlation between induction of DNA fragmentation in|urinary bladder cells from rats and humans and|tissue-specific carcinogenic activity. Toxicology 179:|115-128
Method: other: alkaline single cell gel electrophoresis (SCG) assay
Toxicity to microorganisms, IUC4#56/Ch.4.4
Dean WP (1978) Benzotrichloride acute oral toxicity (LD50)|study in mice. Report No. 163-659 dated November 20, 1978|with cover letter dated 7/27/82. Velsicol Chem Corp. FYI|Submission FYI-OTS-1180-0107. Washington, DC: Office of|Toxic Substances, U.S. Environmental Protection Agency
Flint and MacLean (1988) Teratology 37:456-457.
BASF AG, Stoffdatenservice, PADABA-Berechnung, 05.05.1998, No information
NTP unpublished results, In vitro cytogenetics results chinese hamster ovary cells, data for CY aliquot 679128, (1991)
CIT (2003) MMP Water solubility. Unpublished report|24178PSE of CIT for Thioesters Association. 02 June 2003
Merck Index (2001). The Merck Index, 13th. Ed. (electronic|release). Whitehouse Station, New Jersey, USA.
CIT (2006) Acute Eye Irritation in Rabbits. Study number 26938TAL CIT, Laboratory study: 26938TAL. Study sponsor: L'Oreal.
Reported in Du Pont - Haskell Laboratory - Internal DMAC|Review, Oct. 1988 from Fassett D.W., Unpublished Eastman|Kodak Co. Data (Ref. from Horn H. J. (1959)).
Chan, K.Y. (1985): Altern. Methods Toxicol. 3, 405-422.
Fischer,W.B., Crescentini,L., Kirk-Othmer Ency. Chem. Tech.|18, 425-436, (1982)
Oldersma, H., A.O. Hanstveit, and H.P.M. de Haan. 2004. Methyltin tris (2-ethylhexylmercaptoacetate) (CAS# 57583-34-3 MMT(EHMA)): Determination of the effect on the growth of the fresh water green alga Scenedesmus subspicatus. TNO Chemistry, TNO report V5307/02, June 10, 2004 (revised final August 12, 2004).
Kravets-Bekker A.A. & Ivanova O.P. 1970. Faktory Vnesh.|Sredy Ikh Znachenie Zdorov'ya Naseleniya No.2, 125: in|BIBRA Toxicity Profiles, BIBRA International, Great Britain.
Ma, T.H. and Harris, M.M.: Environ. Mol. Mutagen. 11, 63-64|(1988); abstract no. 153, No information
Genetic toxicity in vivo, IUC4#50/Ch.5.6
Union Carbide Corporation. Chemical Hygiene Fellowship. b|Project Report No. 34-41. Export, PA. 1971.
Huntingdon Life Sciences Ltd. (1999). Tungsten carbide|powder-Pure. Acute oral toxicity to the rat. Unpublished |Report No. ITU 014/982705/AC, June 24, 1999.
Nasr MA, Hwang K-W, Akbas M, Webster, Dale A, Stark BC|(2001). Effects of culture conditions on enhancement of|2,4-dinitrotoluene degradation by Burkholderia engineered|with the Vitreoscilla hemoglobin gene. Biotechnol. Prog.|17(2), 359-361.
Smyth, H.F., Jr. & Carpenter, C.P., J. Ind. Hyg. Toxicol.|30, 63-68 (1948)
Black et al. (1983): Fund. Appl. Toxicol. 3, 353-358
Genetic toxicity in vitro, IUC4#18/Ch.5.5
Boatman RJ. 2001. Glycol ethers: Ethers of propylene,|butylenes glycols, and other glycol derivatives. Chapter 87.|In: Bingham E, Cohrssen B, Powell CH (Eds). Patty’s|Toxicology (Fifth Ed.). New York : John Wiley & Sons, Inc.
Ishidate, M. and Odashima, S. (1977), "Chromosome tests with|134 compounds on Chinese hamster cells in vitro - A|screening for chemical carcinogens", Mutation Research 48,|pp. 337-354
Walton BT, Hendricks MS, Anderson TA, Talmage SS (1989). Treatability of hazardous chemicals in soils: Volatile and semi-volatile organics. ORNL-6451, NTIS DE89016892, Oak Ridge, TN: Oak Ridge Natl Labs.
Pitter P (1976) Determination of Biological Degradability of|Organic Substances. Water Res 10: 231 - 235
Method: other: batch system (comparable to Zahn-Wellens Test)
Method: other: Detection of Mitotic Gene Convertants in the yeast S. cerevisiae strain JD1
Bayer AG (1976). Leuschner F. Blankophor BA 200 %=PSG 125 %|- Lokale Vertraeglichkeit an der Kaninchenhaut (Patch-Test).|Study reported from Laboratorium fuer Pharmakologie und|Toxikologie to Bayer AG dated 1976-07-29.
BASF (1989): Natriumdisulfit, Algentest (Scenedesmus|subspicatus). DUU/OO - A 520, 21.07.1989
Zok, S., Gorge, G., Kalsch, W. and Nagel, R. (1991)|Bioconcentration, Metabolism and Toxicity of Substituted|Anilines in the Zebrafish (Brachydanio rerio).|The Science of the Total Environment 109/110, 411 - 421
Highton, J.D. (2002). Safepharm Laboratories Ltd., N-tert-butylbenzothiazole-2-sulphenamide: Acute oral toxicity in the rat - acute toxic class method, Report No. 1723/003
BASF AG, Department of Toxicology, unpublished study|(87/803), 21.07.88
Method: other: in compliance with OECD Guide-line 403
Safepharm Laboratories Ltd., Derby (1994b): Mutation of L5178Y Mouse Lymphoma Cells at the Thymidine Kinase TK+/-Locus. Fluctuation Assay. Project no. 521/2
BASF AG, Department of Ecology, Wachstumshemmtest in|Anlehung an Bringmann-Kuehn, unpublished study, 9/1059/87,|06 Nov. 1987
Method: other: Pseudomonas Cell-Multiplication Inhibition Assay, DIN 38412, Part 8 (Draft), Bestimmung der Hemmwirkung von Wasserinhaltsstoffen auf Bakterien
Method: other (calculated): EPIWIN v3.12
Method: other: Smyth, H.F. et al., Amer. Ind. Hyg. Assoc., 23, 95-107, 1962
Chemical LAND21 [Web site]|http://www.chemicalland21.com/arokorhi/industrialchem/solalc|/LLYL%20ALCOHOL.htm
Method: other: Bestimmung der akuten Wirkung von Stoffen auf Fische. Arbeitskreis "Fischtest" im Hauptausschuss "Detergentien" (15.10.73)
Smyth,H.F. et al. (1962) Range-finding toxicity data: list|VII. Amer. Ind. Hyg. Ass. J., 30, 470-476.
Method: other: Smyth et al. (1962) as described in remark
Walterson, E., O. Sangfors, and L. Landner. 1993. The Swedish National Chemicals Inspectorate. Swedish Environmental Research Group (MFG). Environmental Hazard Assessment of Mono- and Di-Substituted Organotins. KEMI Report No. 11/94.
Huels AG (1996a). Bestimmung der biologischen Abbaubarkeit|von Isophoron im Zahn-Wellens-Test, Unpublished study.
Livingston AG, Willacy A (1991) Degradation of|3,4-Dichloroaniline in Synthetic and Industrially Produced|Wastewaters by Mixed Cultures freely suspended and|Immobilized in a Packed-Bed Reactor. Appl Microbiol|Biotechnol 35 (4): 551 - 557
Method: other: sealed shake flask (see Test conditions)
Biodegradation in water: screening tests, IUC4#35/Ch.3.5
Barfknecht TR, Maismith RW, Kornbrust DJ (1987) Variations|on the Standard Protcol Design of the Hepatocyte DNA Repair|Assay. Cell Biol and Toxicol 3: 193-207
Method: other: in vitro hepatocyte assay according Maslansky and Williams (1982), In Vitro 18, 683, incubation time: 4 h, autoradiographic measurement
Online Toxicology Data Network(TOXNET): Hazardous Substances Data Bank(HSDB), 2000
Dowden BF and Bennett HJ (1965). Toxicity of selected|chemicals to certain animals. J. Water Pollut. Contr.|Fed. 37(9), 1308-1316.
Genetic toxicity in vitro, IUC4#97/Ch.5.5
Wellens. (1990): Z. Wasser-Abwasser Forsch. 23, 85-98
Short-term toxicity to fish, IUC4#39/Ch.4.1
You, X, Zhou, Y, Hu, Y (1982) Mutagenicity of fourteen rubber accelerators. Huanjing Kexue, 3, 39-42 (as reported in Chem. Abstr. 98:84705t) reported in IUCLID non-confidential dataset, Year 2000 CD-ROM
Method: other (calculated): estimated modifed grain method
Melting point/freezing point, IUC4#14/Ch.2.1
Janssen, P.J.M. (1991), "Primary irritation of|epsilon-caprolactone to the skin of male rabbits", Solvay|Duphar Int. Doc. No. 56645/69/91
Gould E (1959). Mechanism and Structure in Organic|Chemistry. Holt, Reinhart and Winston, New York, NY, USA.
Du Pont, E.I. du Pont de Nemours & Co. data, EPA OTS|86860078 (1953) cited in BIBRA Toxicity Profile (1991)
Skin irritation / corrosion, IUC4#90/Ch.5.2.1
BASF AG (2007). Department of Product Safety,|SPARC-calculations, 16 Mar 2007, unpublished.
Method: other: calculation with SPARC Model v3.1, January 2007 release.
Stephan H, Stephen T (1963) Solubilities of Inorganic and Organic Compounds. Vol I. Binary Systems. Macmillan Co., New York, NY., 1963 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Mak, W.A. 2003. Tetraoctylstannane [CASRN 3590-84-9]: Freezing temperature/freezing range. Report No. PML 2003-C22. TNO Prins Maurits Laboratory, Rijswijk, the Netherlands. March 2003.
USEPA. 2000. BCFWIN. Versions 2.15 and 2.17. BCF Estimate from Log Kow. Office of Pollution Prevention Toxics (OPPTS) and Syracuse Research Corporation.
Salmonella typhimurium TA 98, TA 100, TA 1538
Merck Index (12th Edition), 1996. Merck & Co., Budavari et|al., editors, Whitehouse Station, New Jersey.
BASF AG, Abteilung Toxikologie; unveroeffentlichte|Untersuchung (XXV/219), 20.01.1978
Skin irritation / corrosion, IUC4#24/Ch.5.2.1
Union Carbide Data Sheet (1973): zit. in RTECS, update 8909
Skin irritation / corrosion, IUC4#23/Ch.5.2.1
Kurane R, Suzuki T, Takahara Y. (1977) Microbial degradation|of phthalate esters. Part I. Isolation of microorganisms|growing on phthalate esters and degradation of phthalate|esters by pseudomonas acidovorans 256-1 Agric Biol Chem 41,|2119-23
Degussa AG, unpublished report, 1990, Acute toxicity in Daphnia magna, Degussa Report No. 90-0042-DGO
Rexroat MA, Probst GS (1985) Mutation tests with Salmonella|using the plate-incorporation assay. Prog Mut Res 5: 201-212
Foureman, P., Mason, J.M., Valencia, R. & Zimmering, S.|(1994). Chemical mutagenesis testing in Drosophila. IX.|Results of 50 coded compounds tested for the National|Toxicology Program. Environ. Mol. Mutagen., 23, 51-63.
BASF AG, Sicherheitsdatenblatt Isophytol (30.08.1993)
Adler, I.D. and Schoeneich, J.: Humangenetik 4, 374-376|(1967);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Genetic toxicity in vivo, IUC4#27/Ch.5.6
Minor, J.L. & Becker, B.A., Toxicol. Appl. Pharmacol. 19,|373 (1971)
Monsanto Co. (1983) In vivo bone marrow chromosome study in|rats. Nitrated orthene (3,4-dichlornitrobenzene). Final|report no. HL-83-194. Hazleton Lab. America, Inc.|(OTS0534375, 86-920000170)
Method: other: according to Evans HJ (1976) Cytological methods for detecting chemical mutagens. In: Hollaender A (ed.) Plenum Press, NY and Killian DJ et al. (1977) Handbook of mutagen testing. Elsevier, Amsterdam. see also freetext TC
BASF AG (1987). Department of Ecology, study No. 01.769|(unpublished).
Method: other: static test (river water die away test)
Al'meev et al.(1939). Cited in: Rowe VK and MC Collister SB|(1982), in Patty's Industrial Hygiene and Toxicology. 3rd|edition vol. 2C.
Kirner K (1989). Zur Metallurgie der Wolframcarbide beim|thermischen Spritzen. Schweißen und Schneiden 11, 583-586.
Kushneva V.S. et al.: Gig. Tr. Prof. Zabol., 1, 46-47, (1983); cited in WHO: Environmental Health Criteria 65, WHO,pp. 93 ff., (1987) as cited in IUCLID.
Acute toxicity: inhalation, IUC4#120/Ch.5.1.2
MHLW, Japan (2004e) Ministry of Health, Labour and Welfare: Preliminary reproduction toxicity screening test of 4-Methylbenzoic acid by oral administration in rats. Japan Toxicity Testing Reports of Environmental Chemicals, 11, 216-228.
Method: other: vault-type stainless steel chambers of 3700 l capacity
USEPA. 2000. BCFWIN. Version 2.15. BCF Estimate from Log Kow. EPIWIN (Estimation Program Interface for Windows). Version 3.11. Office of Pollution Prevention Toxics (OPPTS) and Syracuse Research Corporation.
Huntingdon Life Sciences Ltd. (1999). Tungsten carbide|powder - Pure. Acute (four-hour) inhalation study in rats.|Unpublished Report No. ITU 019/983502, May 28, 1999.
Moriyama IS, Hiraoka K, Onishi Y and Yamaguchi R.|Effect of FBA-260 on the pregnant rat. Teratology 14: 247,|1976.
Developmental toxicity / teratogenicity, IUC4#30/Ch.5.8.2
Van't Hof, J. and Schairer, L.A.: Mutat. Res. 99, 303-315|(1982)
Van Bever, H.P. et al., Allergy 44, 588-594 (1989)
Huels AG (1987). unpublished report No. DYN 1/S. Study to|determine the ability of 18 compounds to induce mutation in|three histidine-requiring strains of Salmonella typhimurium|Degussa AG-Reg-Nr.: 87-0235-DKM.
Zimmer D, Mazurek G, Petzhold G, Bhuyan BK (1980) Bacterial|Mutagenicity and Mammalian Cell DNA Damage by Several|Substituted Anilines. Mutat Res 77: 317-326
Method: other: alkaline elution method according to Swenberg et al., 1976, Biochem Biophys Res Commun 72, 732
Genetic toxicity in vitro, IUC4#114/Ch.5.5
Brooke, L.T. et al., 1984. Acute Toxicities of Organic|Chemicals to Fathead Minnows (Pimephales promelas). Vol. I.|Center for Lake Superior Environmental Studies. University|of Wisconsin-Superior.
Hüls AG (1987). Goldorfentest nach DIN 38412 Teil 15. Report|No. F824 (unpublished)
BASF AG (1969) Acute inhalation toxicity of choline chloride|50% powder. Department of Toxicology, unpublished results,|Study No. XIX/271, 08.Jul.1969
Gras, G. and J-A. Rioux. 1965. Relation entre la Structure Chimique et l'Activite Insecticide des Composes Organiques de l'Etain (Essai sur les Larves de Culex pipiens pipiens L.). Arch. Inst. Pasteur Tunis. 42:9-22.
HSDB database (through 2006/09). Available online via TOXNET|at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB.
Trénel J and Kühn R (1982). Bewertung wassergefährdender|Stoffe im Hinblick auf Lagerung, Umschlag und Transport -|und - Untersuchung zur Abklärung substanz- und|bewertungsmethoden-spezifischer Grenzfälle bei der Bewertung|wassergefährdender Stoffe. Report to Federal Environmental|Agency (UBA), July 1982.
Method: other: Growth inhibition test according to Bringmann & Kühn
Bringmann G (1978). Bestimmung der biologischen Schadwirkung|wassergefaehrdender Stoffe gegen Protozoen I.|Bakterienfressende Flagellaten (Modellorganismus: Entosiphon|sulcatum Stein). Z. Wasser Abwasser Forsch. 11(6), 210-215.
Method: other: Acute Inhalation Toxicity
Industrial BIO-TEST Laboratories, Inc., 1975.
Environment Agency Japan (1994): Investigation on the|Ecotoxicological effects of OECD High Volume Chemicals|(Phase 3): p. 167 - 208.
Fuller B, Hushon J, Kornreich M, Quellette R, Thomas L, and|Walker P (1976). Preliminary scoring of selected organic air|pollutants. The Mitre Corporation, McLean, VA; prepared for|U.S. EPA, report No. EPA-450/3-77-008a, Oct 1975.
Morrissey RE, Schwetz BA, LambIV JC, Ross MD, Teague JL,|Morris RW (1988) Evalutation of rodent sperm, vaginal|cytology, and reproductive organ weight data form national|toxicology program 13-week studies. Fundam Appl Toxicol 11:|343-358
Method: other: Sperm Morphology and Vagina Cytology Examination (SMVCE), see also freetext Test substance
Method: other: calculated with HYDROWIN, vers. 1.64
Grillo, C.A. & Dulout, F.N., Mutation Research 375, 83-89|(1997)
Genetic toxicity in vitro, IUC4#292/Ch.5.5
Vachhrajani KD, Sahu AP, Dutta KK (1993) Excess choline a|vailability: a transient effect on spermatogenesis in the|rat. Reproductive Toxicology 7: 477-481
BASF (1988) Acute toxicity to Daphnia magna (0040/88). BASF|AG, Department of Ecology, 11.02.1988 (unpublished data)
Vernot E.H. et al.: Toxicol. Appl. Pharmacol. 42, 417-423,|(1977)
Acute toxicity: inhalation, IUC4#58/Ch.5.1.2
BASF AG, Analytical Department, unpublished data,|(04.03.81)
Method: other: Zahn-Wellens-Test, analytic: COD
Method: other: OECD Guideline 415 (1983)
Beilstein Database. Copyright 1988-2001 Beilstein Institut|zur Foerderung der Chemischen Wissenschaften. CrossFire|Beilstein, licensed by MDL Information Systems GmbH,|research update: 23 Apr 2004.
Monsanto Study IR-78-195 as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Monticello, T.M. and Morgan, K.T.: Proc. Am. Assoc. Cancer|Res. 30, abstract no. 772 (1989), No information
Repeated dose toxicity: inhalation, IUC4#122/Ch.5.4
Springborn Institute for Bioresearch, Inc. (1984) Photoallergic contact dermatitis by resorcinol in guinea pigs (Armstrong Method). Submission of unpublished data by the Cosmetic, Toiletry and Fragrance Association [cited in Cosmetic Ingredient Review, 1986].
Genetic toxicity in vitro, IUC4#117/Ch.5.5
APCI, 1,4-Diazabicyclo[2.2.2]Octane (Static): Acute Toxicity|Study in Daphnia Magna (OECD 202, Part 1), unpublished|study, APCI RRRS EXT-00/009, 28 Jan 2000
BOD5 Method: other: American Public Health Assoc., 1971
Adams R. M. in Maibach H.I., G.A. Gellin (eds.),|Occupational and Industrial Dermatology, Chicago, Year Book|Publishers, Inc., p. 345-352 (1982)
E.I. du Pont de Nemours, HLR 772-88, 14 Dec.1988
Method: other: ALC method (comparative screening)
Method: other: standard sensitization test
Skin irritation / corrosion, IUC4#9/Ch.5.2.1
Yamaguchi T (1980). Mutagenicity of Isothiocyanates,|Isocyanates and Thioureas on Salmonella typhimurium,|Agriculture and Biological Chemistry 44, 3017-3018
Mortelmans K., Haworth S., Lawlor T., Speck W., Tainer B.,|Zeiger E. (1986) Salmonella mutagenicity test: II. Results|from the testing of 270 chemicals, Environ. Mutagen., Vol.|8, Suppl. 7,1-119
Takemoto S, Kuge, Y, and Nakamoto M (1981). The measurement|of BOD in sea water. Suishitsu-Odaku-Kenkyu (Japanese|Journal of Water Pollution) 4, 80-90.
Biodegradation in water: screening tests, IUC4#4/Ch.3.6
BASF AG (2003). Amasil Natriumsalz. Material safety data|sheet according to 91/155/EEC, last update 26 May 2003.
Groeneveld, A.H.C. and Kuijpers, L.A.M., (1990). The acute|toxicity of 1-chloro-1,1-difluoroethane (HCFC 142b) to the|Guppy Poecilia Reticulata. Report No. 56635/33/90 DUPHAR|B.V.
Method: other: OECD guideline 203 (1984) and EPA guidelines 72-1 (1982)
Burgess, D. Acute Flow-through Toxicity of Butyl Acrylate|to Daphnia magna. Testing Facility: Analytical|Bio-Chemistry Laboratories, Inc., Columbia, MO. Project|Identification No. 37340. Study Date: March 23, 1990.
Hoechst AG (1982) Unpublished study W82-082
Short-term toxicity to aquatic invertebrates, IUC4#170/Ch.4.2
Rohm and Haas Co. 1979. Acute Oral Toxicity of 1185-13, 28G082, 28H047, 1185-114, 1219-21, 1185-150, 1185-119 and 1185-138 in Weanling Sprague-Dawley Rats. Study conducted by Cannon Laboratories, Inc. for Cincinnati Milacron.
Method: other: not reported - similar to OECD 401
Koch B, Ostermann M, Hoeke H and Hempel DC (1991). Sand and|activated carbon as biofilm carriers for microbial|degradation of phenols and nitrogen-containing aromatic|compounds. Wat. Res. 25(1), 1-8.
Method: other: according Koch and Ostermann. Wat. Res. 25(1), 1-8
Biodegradation in water: screening tests, IUC4#175/Ch.3.5
Mutagenicity evaluation of Genetron 124, Litton Bionetics,|Inc, Maryland, USA, LBI Project No 2547, July 1976. Study|for Allied Chemical Corporation.
Hoechst AG (1986) p-Nitrotoluol Prüfung auf Hautreizung am|Kaninchen. Unveröffentlichter Bericht Nr. 86.0361,|26.03.1986
Bomhard E, Löser E, Suberg H (1982) Acute toxicological|evaluation of sodium sulfite. Int J Toxicol 2000: 349-350
Method: other: test procedure comparable to OECD guideline 404, evaluation according to Draize
Method: other: single dermal applicationf exposure time: 2-6 hours, immediately afterwards methemoglobin determination according to Evelyn-Malloy
Bringmann G, Kuehn R (1960) Vergleichende oxikologische Befund an Wasser-Bakterien. Gessundheits-Ingenieur 81:337-339.
Method: other: Inhibition of glucose degradation; investigation not performed to any guideline
Toxicity to microorganisms, IUC4#15/Ch.4.4
Nagorny et al.: Gig. Truda Profzabol. 7, 27-30 (1979);|(translated from Russian), No information
Repeated dose toxicity: inhalation, IUC4#132/Ch.5.4
Baumgarten J, Mann T, Schmidt F (1982) Mehrfach|substituierte aromatische Kohlenwasserstoffe abbauende|Mikrooganismen-Kulturen, Verfahren zu ihrer Herstellung und|ihre Verwendung in biologischen Kläranlagen. DE 32 25 885,|Deutsches Patentamt (10.07.1982/12.01.1984; Bayer AG)
Elmore, E. & Fitzgerald, M.P., zitiert nach: Mutation and|the Environment, Part D, Wiley-Liss, Inc., 379-387 (1990)
Method: other: according to Ulitzur et al. (1980)
Budavari S (ed) (1996)The Merck Index - An Encyclopedia of|Chemicals, Drugs, and Biologicals. 13 th ed.,Merck & Co.,|Inc. 1574
Solubility in organic solvents / fat solubility, IUC4#3/Ch.2.6.1
Budavari, S. (ed.). The Merck Index - An Encyclopedia of|Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ:|Merck and Co., Inc., 1996., p. 1043. cited in HSDB 21 Sep|2006
Koopman, T.S.M. and Pot, T.E. (1986) Acute oral toxicity|study with anhydrous calcium chloride in male rabbits.|Duphar Report No. 56645/52/86.
National Toxicology Program (NTP), 87-001 Annual Plan for|Fiscal Year, May, 1987
Balynina E.S.: Gig. Tr. Prof. Zabol. 31 (4), 55, (1987)
Method: other (measured): no information available (IUCLID data set)
BASF AG, department of ecology, unpublished data (Report No.|99/0484/60/1), 04.05.2000
Short-term toxicity to fish, IUC4#82/Ch.4.1
Schmidt RJ and Chung LY (1992) Biochemical responses of skin|to allergenic and non-allergenic nitrohalobenzenes: Evidence|than an NADPH-dependent reductase in skin may act as a|prohapten-activating enzyme. Arch Dermatol Res 284: 400-408
Method: other: 5 mice,induction made on shaved back, non irritant conc. was chosen for challenge and was applied to the surface of one ear, reading after 24, 48, 72 h, no further details given
Method: other: Rates of hydrolysis were measured in 1:1 acetone-water mixture.
BASF AG, Sicherheitsdatenblatt Trishydroxyethylisocyanurat (13.04.1994) cited in IUCLID (2000)
Hoechst AG (1977) Unveröffentlichte Untersuchung (77.0374) Unpublished investigation.
Method: other: Hoechst Ag Internal Directive, 1977
Matsuoka A, Yamakage K, Kusakabe H, Wakuri S, Asakura M,|Noguchi T, Sugiyama T, Shimada H, Nakayama S, Kasahara Y,|Takahashi Y, Miura KF, Hatanaka M, Ishidate M Jr, Morita T,|Watanabe K, Hara M, Odawara K, Tanaka N, Hayashi M et al.|(1996). Re-evaluation of chromosomal aberration induction on|nine mouse lymphoma assay 'unique positive' NTP carcinogens,|Mutat. Res. 369, 243-252.
Toxicity to aquatic algae and cyanobacteria, IUC4#24/Ch.4.3
Enclosed static vapor phase exposure chambers
Galloway SM, Armstrong MJ, Reuben C, Colman S et al. (1987)|Chromosome observations and sister chromatid exchanges in|chinese hamster ovary cells: Evaluation of 108 chemicals.|Environ Molec Mutagen, 10 suppl. 10, 1-175.
Method: other: equivalent to OECD Guide-line 473
Hommel G (1992) Handbuch der gefaehrlichen Gueter, Merkblatt|1284, Springer-Verlag, Berlin Heidelberg, S. 1992
CERI. (2004) Measurement of dissociation constant of p-toluic acid. Unpublished data.
Barrett JC, Lamb PW (1985) Tests with the Syrian hamster|embryo cell transformation assay. Prog Mut Res 5: 623-628
Method: other: according Berwald and Sachs, 1965, J. Natl. Cancer Inst. 35, 641-661
Schatz A, Trelawny S, Schatz V and Mohan RR (1957).|Metabolism of Esters by Streptomyces nitrificans. Proc. Soc.|Exp. Biol. Med. 94, 702-705.
Method: other: Warburg Respirometric Experiment
Nalbandyan, T.I. et al., Zh. Eksp. Klin. Med., 25, 335 - 339 (1985)
DuPont Haskell Laboratory, OTS Document 84003A ID 878220440,|12/82
GESTIS - Substance database of 'Berufsgenossenschaftlichen|Instituts für Arbeitsschutz' (BGIA), query date 30 May 2007
Melting point/freezing point, IUC4#25/Ch.2.1
Fu, J.: Weisheng Dulixue Zazhi 5, 247-249, 263 (1991), No information
Kennedy, G.L. jr. et al.: J. Appl. Toxicol. 6, 145-148|(1986)
Sheu, C.W. et al. (1986): Environ. Mutagen. 8, 357 - 367
Genetic toxicity in vivo, IUC4#69/Ch.5.6
Bayer AG data: Loeser, E.: o-Nitrochlorbenzol. Untersuchun-|gen zur akuten oralen Toxizitaet an weiblichen Wistar-Rat-|ten, April 1, 1982
Method: other: 10 rats/dose, 5 doses, test subst. dissolved in lutrol, gavage: application volume: 20 ml/kg bw., observation time: 14 d, some of the animals, that died, and some of the survivors were dissected
Test species/strain :Salmonella typhimurium TA100, TA1535, TA98, TA1537, Escherichia coli WP2 uvrA/pKM101
Degussa AG, unpublished report, 1985, Augenreizung Kaninchen. Degussa Report No. 85-0070-DKT
Martin B.E., Du Pont Company Data, Haskell Laboratory,|Unpublished Data: Report No. 464-76-MR No. 2389-001.
Escherichia coli WP2, WP67, CM871; and Samonella TA97, TA102
Rudio J., 1991, Linalyl acetate synthetic determination of the ready biodegradability, Givaudan
In vitro assessment of the clastogenic activity of HCFC-124|in cultured Chinese hamster ovary (CH0-K1) cells, Life|Science Research Ltd., eye, Suffolk, England, LSR Report No.|91/PAR002/0885a, December 1991. study performed for PAFT|III Group.
Method: other: OECD Guideline 473O, US EPS TSCA guidelines (1985, amended 1987) and Japanese MITI (1987 and MHW (1990) guidelines
Bayer AG (2002) Calculation of|- log Octanol-Water-Partition Coefficient with SRC-KOWWIN v.|1.66, 2000|- Henry's Law Constant with SRC-HENRYWIN v. 3.10, 2000|- Indirect Photodegradation with SRC-AOPWIN v. 1.89, 2000|- Soil Adsorption Coefficient with SRC-PCKOCWIN v. 1.66,2000|- Mackay-Distribution Level I according to Mackay, D., 1991
Method: other: (calculated) SRC-PCKOCWIN v1.66 (2000)
Salmonella typhimurium TA98, TA100, TA1535, TA1537; E. coli WP2 uvrA
BASF AG, Safety data sheet Coffein Anh. Gr. Plv. 1A001BK1,|07.06.2001
APCI, Triethylenediamine: A Combined 28-Day Repeated Dose|Oral Toxicity Study with the Reproduction/Developmental|Toxicity Screening Test in Rats, with Recovery (OECD 422),|unpublished study, APCI RRRS EXT-00/085, 11 Jul 2000
Degussa AG, ZFE: Durchfuehrung der Pruefung nach der|"Kolben-Methode" in A.6. Wasserloeslichkeit (aus Amtsblatt|der Europaeischen Gemeinschaften, Nr. L 383 A/54 FF. v.|29.12.92), ZFE ID-No. 1998-25002, 03 Aug. 1998 [Degussa|US-IT-Nr. 98-0101-DKO]
Monsanto Study No. IR-78-95 as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Repeated dose toxicity: inhalation, IUC4#70/Ch.5.4
BASF AG, unpublished calculation, EPISUITE, ECOSAR, V0.99, 2002
Short-term toxicity to fish, IUC4#23/Ch.4.1
Florin et al. (1980) Toxicology 18, 219-232.
Suzuki, T., Journal of Computer-Aided Molecular Design, 5|(1991) 149-166
Sewell, I.G. and Grant-Salmon, D. (1993) The Acute Toxicity|to Aminoethylpiperazine to Rainbow Trout. Akzo Nobel|Sponsored study, project number 142/126, Safepharm|Laboratories Limited, Derby, UK.
BASF AG, Safety data sheet ISODUR 0-1,6MM, 06.12.1996
Industrial Bio-Test Laboratories, Inc., Data Sheets|26-4/1973. As cited in: Berufsgenossenschaft der chemischen|Industrie (1995): Toxikologische Bewertung. Beta-Naphthol.|Nr. 135, Heidelberg
Clark, C. R. et al., Toxicological assessment of heat|transfer fluids proposed for use in solar energy|applications, Toxicol. Appl. Pharmacol., 51, 529-535, 1979|(87).
Genetic toxicity in vitro, IUC4#121/Ch.5.5
Method: other: Method by US-EPA 1975 (EPA-660/3-75-009)
Method: other (calculated): MPBPWIN (v1.31) Program; Modified Grain Method
1,2-Benzenedicarboxylic acid, di-C7-11-branched and linear alkyl esters
Bruehl, E.M. and Einbrodt, H.J.; Wissenschaft und Umwelt|3/1987, 167-170 (1987), No information
Short-term toxicity to aquatic invertebrates, IUC4#130/Ch.4.2
BASF AG, Analytisches Labor, unveröffentlichte Untersuchung,|J.Nr. PH 6234, 16.03.1978
Method: other: determination of vapour pressure
Norsk Hydro ASA (2002). Formi LHS. Material safety data|sheet, last update 28 Jun 2002.
Engelhardt, Wallnoefer, Rast (1976): Arch. Microbiol. 109,|109-114
Nagase, H., T. Hamasaki, T. Sato, H. Kito, Y. Yoshioka, and Y. Ose. 1991. Structure-activity relationships for organotin compounds on the red killifish Oryzias latipes. Applied Organometallic Chemistry. 5:91-97.
Chemicals Evaluation and Research Institute (CERI), Japan|(2001), unpublished data.
Warne MS, Schifko AD (1999). Toxicity of laundry detergent|components to a freshwater cladoceran and their contribution|to detergent toxicity. Ecotoxicol. Environ. Saf., 44,|196-206.
Method: other: method developed by NSW Environment Protection Authority (Warne & Julli, 1999)
Yoshioka Y, Ose Y, Sato T (1985) Testing for the toxicity of|chemicals with Tetrahymena pyriformis. Science Total Environ|43: 149 - 157
Amoco Corporation. 1997. Material Safety Data Sheet.|(www.vetmed.ucdavis.edu/msds/mf/Amoco/files/01260000.html)
Ohuchida A, Furukawa AA, Yoshida R (1989) Micronucleus test|of polyploidy inducers. Mut Res 216: 371-372
Database from EPIWIN-Software, v.3.10 of U.S.Environmental|Protection Agency (2000).
Method: other: reported from database of calculation program
Reported in TOXALL-Data Bank from Du Pont, Haskell|Laboratory (1984). Toxicity studies on DMF and DMAC with|cover sheets and letter dated 092484. EPA/OTS:Doc.|86-890000747S.
CERI. (2004) Measurement of water solubility of p-toluic acid. Unpublished data.
Kuehn R, Pattard M, Pernak K-D (1988) Schadstoffwirkungen|von Umweltchemikalien im Daphnien-Reproduktionstest als|Grundlage für die Bewertung der Umweltverträglichkeit in|aquatischen Systemen. UFOPLAN Nr. 106 03 052/01 des BMU
Method: other: DIN 38 412, Part 9 (Cell multiplication inhibition test)
Design Institute for Physical Property Data (DIPPR),|American Institute of Chemical Engineers (AIChE), New York,|N.Y., U.S.A.
Method: other: experimental measurement (method not specified)
Wolf, D., Morgan, K., Gross, E. et al. (1995): Two-year|inhalation exposure of female and male B6C3F1 mice and F344|rats to chlorine gas induces lesions confined to the nose.|Fundamental and Applied Toxicology, 24(1), 111-131.
Rekha P, Chandra Mouli B, Vijaya Kumari SG, Indumathi C, and Mithyantha MS (2006). Studies on the identification of|suitable solvents for microbial bioassay. Current Science|90(12), 1663-1667.
Method: other: "poisoned agar technique"
Monticello, T.M. et al.: Toxicologist 12, abstract no. 1017|(1992), No information
Tchounwou PB, Wilson B, and Ishaque A (2000). Toxicity and|risk assessment of 2,4,6-trinitrotoluene, 2,4-dinitrotoluene|and 2,6-dinitrotoluene.|http://www-esd.lbl.gov/CEB/BEST/ann_rpt99/Eco_3story.html.
Monticello, T.M. et al.: Am. J. Path. 134, 515-527 (1989), No information
Repeated dose toxicity: inhalation, IUC4#97/Ch.5.4
Zeiger, E. et al. (1992) Environ. Mol. Mutagen., 19, suppl.21, 2-141.
Biodegradation in water: screening tests, IUC4#12/Ch.3.6
Fujita T, Iwasa J and Hansch C (1964). A New Substituent|Constant derived from Partition Coefficients. J. Am. Chem.|Soc. 86, 5175-5180.
Velsicol Chem. Corp. (1979): Acute inhalation toxicity study|in rats. Report No 163-662. 27 April 1979. As submitted to|U.S. EPA under TSCA on 20 Nov. 1980, U.S. EPA TSCA|FYI-OTS-1180-0107 IN.
CIIT (1984). Ninety day inhalation toxicity study of|hydrogen chloride gas in B6C3F1 mice, Sprague dawley and|Fischer 344 rats. ToxiGenics, 420-1087.
Albertini, Zimmermann (1991) The detection of chemically|induced malsegregation in Saccharomyces cerevisiae D61.M: a|literature survey (1984-1990). Mutat Res 258: 237-258
Genetic toxicity in vitro, IUC4#67/Ch.5.5
BASF AG, Safety data sheet THIODIGLYCOL HP, 22.04.2002
Defitraces (2003) Report number 02-902003-058. Freezing|point of IOTG. April 3, 2003.
Ciba-Geigy, Ltd. Final Report TK 12700/1. 24 Month Carcinogenicity Study in Rats. GU Project No. 800218. 2.1.1986.
Reported in AIDA (13/11/92)- ALSTOFF INFORMATION Date Bank|from Zeiger E. et al. (1988). Environm. Molec. Mutagen.,|11(suppl. 12):1-158.
Allied Corporation (1984) Primary dermal irritation of vinyl|oximino silane (VOS). Internal study. Allied Corporation|Department of Toxicology. Jan 23, 1984
Method: other: Modified Draize procedure
BASF AG, Abteilung Toxikologie; unveroeffentlichte|Untersuchung (88/600), 15.02.1989
LeBlanc GA (1980). Acute toxicity of priority pollutants to|water flea (Daphnia magna). Bull. Environ. Contam. Toxicol.|24 (5), 684-691.
MITI, Biodegradation and Bioaccumulation: Data of Existing|Chemicals Based on the CSCL Japan, Compiled under the|Supervision of Chemical Products Safety Division, Basic|Industries Bureau MITI, Ed. by CITI, October 1992.|Published by Japan Chemical Industry Ecology-Toxicology|& Information Center
Method: other: Japanese Industrial Standard (JIS K 0102-1986-71) "Testing methods for industrial waste water" (1986)
MHLW (Ministry of Health, Labour and Welfare), Japan (2004).|Toxicity testing reports of environmental chemicals. 11,|241-285.
Method: other: Guidelines for Screening Mutagenicity Testing of Chemicals (Chemical Substances Control Law of Japan) and OECD Test Guideline 473
Fekadu K, Parzefall W, Kronberg L, Franzen R,|Schulte-Hermann R, Knasmueller S (1994) Induction of|genotoxic effects by chlorohydroxyfurane, byproducts of|water disinfection, in E. coli K.12 cells recovered from|various organs in mice. Environ Molec Mutagen 24: 317-324
Method: other: according to Knasmueller S.: Bull. Pol. Acad. Sci., 364, 225-234, (1988)
Oser BL, Carson S and Oser M (1965). Toxicological tests on|flavouring matters, Fd. Cosmet. Toxicol. 3, 563-569
Meng Z, Qin G, Zhang B, Bai J (2004) DNA damaging effects of|sulfur dioxide derivatives in cells from various organs of|mice. Mutagenesis 19: 465-468
Method: other: quantitation of DNA damage by comet assay or single cell gel electrophoresis technique
BASF AG (1989). Department of Ecology. Study performed at|Dr. U. Noack-Laboratory, BASF project No. 01/89/0733, 11 Oct|1989, unpublish
Method: E07-04:German Industrial Standard DIN 38412 Part 11
Salmonella typhimurium reverse mutation assay
Vasilenko NM and Zvezdai VI (1981) Possibility for the|mathematical prediction of some criteria for the toxicity of|nitro and amino compounds. Gigiena Truda i professionalnye|Zabolevaniia 25: 50-52
PB82-190182; NTP-Report NTP-80-26, NIH Publication No.|81-1770, (1982), Technical report series No. 214.
RTECS, Acrylic acid, isobutyl ester, Update 1998/07
Preincubation; S. typhimurium TA97, TA98, TA100, TA1535
TNO (1997). TNO Nutrition and Food Research institute. Acute|(4-hr) inhalation toxicity study with Formi LHS-S in rats.|Unpublished study report No. V97.684 dated October 1997.|Sponsored by Hydro Nutrition, Oslo.
Method: other (calculated): SRC Kowwin v1.66 Computer Program, integrated in U.S. EPA's EPI program Vers. 3.10
Ministry of Health & Welfare, Japan (1999a): Toxicity Testing Reports of Environmental Chemicals, vol 7, 258-261, "Reverse Mutation Test of 2,4-Diamino-6-phenyl-s-triazine on Bacteria".
Covance Laboratories (1998). LHS Super. Eye irritation study|in the rabbit. Unpublished final study report No.|1516/4-1032 dated January 1998. Sponsored by Hydro|Nutrition, Oslo.
Olson, K.J. (1958) Results of range finding toxicological|tests on N-(2-aminoethyl)-piperazine. Unpublished Dow|Chemical Company report.
Method: other: pre OECD and EC guidelines
Monsanto Co. (1955) Toxicological investigation of|dichloronitrobenzene. Scientific Associates, St. Louis|(OTS0534354, 86-920000148)
CIBA-GEIGY Ltd. 1993. Report on the acute toxicity test of Irgastab T 22 M to Zebra-Fish (Brachydanio rerio). Test No.: 928291. Basle, Switzerland. 22/04/93.
BRRC, study report no. 92U1196, 16 May 1995 (sponsored by|Union Carbide Corporation)
Short-term toxicity to fish, IUC4#150/Ch.4.1
BASF AG (1973). Department of Toxicology, repeated dose toxicity rabbit, unpublished study, Study No. XXI/183, 26 March 1973.
Hodson J (1988). The estimation of the photodegradation of|organic compounds by hydroxyl radical reaction rate|constants obtained from nuclear magnetic resonance|spectroscopy chemical shift data. Chemosphere 17(22),|2339-2348.
Huels AG, unpublished results (Nr. 0359), Feb. 05, 1985
Kaiser KLE and Palabrica VS (1991). Photobacterium phosphoreum Toxicity Data Index, Water Poll. Res. J. Canada , 26, 3, 361-431.
TSCATS: OTS0534601, Doc. I.D. 88-920000152, Union Carbide|Corp. letter to USEPA, 07 Nov. 1991
Boyer, I.J. 1989. Toxicity of dibutyltin, tributyltin and other organotin compounds to humans and to experimental animals. Toxicology. 55:253-298.
Genetic toxicity in vitro, IUC4#112/Ch.5.5
Worthing CR (ed.). (1979). The Pesticide Manual. 6th ed.|British Crop Protection Council, Worcestershire, England, 9
Ciss M (1978) Dissertation, Etude analytique, toxicologique|et biochimique des derives monoitres du toluene. Universite|Rene Descartes de Paris: Serie E, No 17
Petrosyan FR, Gizhlaryan MS (1984). Experimental study of local and skin-resorptive effect of chemicals used in the manufacture of chloroprene rubber from butadiene. Gig. Tr. Prof. Zabol. 4, 51-53. Cited in: Chemical Abstracts 101, 18652c (1984).
ECETOC, 1994. Joint Assessment of Commodity Chemicals No. 27, n-Butyl Acrylate
Weissmahr KW, Hildenbrand M, Schwarzenbach RP, Haderlein SB|(1999) Laboratory and Field Scale Evaluation of Groundwater|Transport of Nitroaromatic Ammunition Residues. Environ Sci|Technol 33: 2593 - 2600
Adsorption / desorption, IUC4#9/Ch.3.3.1
BASF AG (1988). Department of Ecology. Acute toxicity to|Dahphnia magna, study report No. 1/0290/2/88-0290/88, 22 Apr|1988, unpublished.
Method: other: Directive 79/831/EEC, Annex V, Part C
Grosjean D, Grosjean E and Williams EL (1993). Atmospheric|Chemistry of Unsaturated Alcohols. Environ Sci Technol 27,|2478-2485
Huls (1994) Dynasylan MEMO-E: Determination of the effect of|Isobutyltriethoxysilane (Dynasylan IBTEO) on the growth of|Scenedesmus subspicatus (Algal growth inhibition test|complying with Directive 88/302/EEC). Final Report AW 237.|Degussa AG-US-IT-Nr.: 94-0267-DGO January 14, 1994
Method: other: Metaphase analysis of bone marrow cells
Genetic toxicity in vivo, IUC4#39/Ch.5.6
Liu Z, Wang L, Ni H, Kong Z (1997) QSAR for biotoxiction of|aromatic compounds. Chinese Sci Bull 42 (5): 380 - 385
Lahti A. Nonimmunologic contact urticaria. Acta.|Dermato-Venereol. Suppl.,60(91): 1-49. 1980.
Swenberg, J.A. et al.: "Localization and Quantitation of|Cell Proliferation following Exposure to Nasal Irritants";|in: Barrow, C.S. (ed.): "Toxicology of the Nasal Passages",|Hemisphere Publishing Corp., Washington, New York, London|(1986), No information
Repeated dose toxicity: inhalation, IUC4#58/Ch.5.4
Ceyzeriat, L. (1960) British Patent GB0856321
Kalsch, W.; Nagel, R.; Ulrich, K. (1991) Chemosphere 22,|351-363
Bioaccumulation: aquatic / sediment, IUC4#12/Ch.3.7
Dickson, K.L, Cairns, J., Greg, B.C., Messenger, D.J.,|Platin, J.L., Van der Schalie, W.H. (1977); Effects of|intermittent chlorination on aquatic organisms and|communities; J. WPCF, 35-44.
Short-term toxicity to fish, IUC4#48/Ch.4.1
Method: other: carcinogenicity in vivo after repeated dermal application
Ullmann's Encyclopedia of Industrial Chemistry (1993). 5th |edition, Volume A22: Poly(Vinyl Esters) to Reduction. Edited|by Elvers B, Hawkins S, Russey W, and Schulz G. Wiley-VCH|Verlag GmbH, Weinheim, Germany, 457-463.
Melting point/freezing point, IUC4#16/Ch.2.1
BASF AG, Department of Toxicology, Study of the prenatal|toxicity of Isobutylidene-di-urea in rats after oral|administration (gavage), unpublished study (90/727) for BG|Chemie, Heidelberg. Feb 03, 1993
Chin TY, Tyl RW, Popp JA, Heck HD. (1981) Chemical |urolithiasis. 1. Characteristics of bladder stone induction|by terephthalic acid and dimethyl terephthalate in|weanling Fischer-344 rats. Toxicol Appl Pharmacol 58(2),|307-21
Grochowska, M.J. and Buta, G.J., Scientia Horticulturae, 26,|217-224 (1985)
Thomann P and Krüger L (1974b). FAT 65'023/C - Irritation to|the rabbit eye (single administration). Report Exp.No.|77/74, December 10, 1974. Toxicology/Pathology,|Pharmaceuticals Division, Ciba-Geigy Ltd., Basel,|Switzerland.
Method: other: AFDO, 1959 (Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics)
Daubert, Thomas E.; Danner, Ronald P.; Physical and thermodynamic properties of pure chemicals, Design Institute for Physial Property Data American Institute of Chemical Engineers, Taylor & Francis, eds., 1998
Morton International, Germany, unpublished report (1992).|Cited in attachment 2 to a letter from Dow dated 17 May 1994.
Short-term toxicity to fish, IUC4#85/Ch.4.1
Short-term toxicity to aquatic invertebrates, IUC4#32/Ch.4.2
Clariant GmbH (2000) : Project-No. 000901CK Dr. U.|Noack-Laboratorium für Angewandte Biologie (04.10.2000)
USEPA. 2000. BCFWIN. Version 2.15. BCF Estimate from Log Kow. EPIWIN (Estimation Program Interface for Windows). Version 3.11. Office of Pollution Prevention Toxics (OPPTS) and Syracuse Research Corporation (personal communication from C. Staples, Assessment Technologies, Inc., 10/30/04).
Chu I, Shen SY, Villeneuve DC, Secours VE (1984) Toxicity of|trichlorotoluene isomers: A 28-day feeding study in the rat.| J Environ Sci Health B19: 183 - 191
Vilsmeier, K. (1980). Z. Pflanzenernaehr. Bodendk. 143,|113-118.
BASF AG (2002). BASF isophorone diamine exposure|questionnaire (unpublished).
Ema, M., T. Itami, and H. Kawasaki. 1991. Teratogenicity of di-n-butyltin dichloride in rats. Toxicology Letters. 58:347-356.
Cannon Laboratories, Inc. (1974) Skin Sensitization study of Vicinal Isomer Mix in guinea pigs. Reading PA. Report No. 4E-4020. Air Products and Chemicals, Inc.
Toth, B., Fundam. Appl. Toxicol. 4, 494-496 (1984)
Waggy GT. 1987. Glycol ethers: Summary of available|ecological fate and effects data. Union Carbide Corporation|File No. 35931
Heil J, Reifferscheid G, Waldmann P, Leyhausen G, Geurtsen W|(1996). Genotoxicity of dental materials. Mutation Res. 368,|181-194.
Method: other: as described by Reifferscheid, G., Mutation Res. 253, 215-222 (1991)
BASF AG, Abteilung Toxikologie. 1994. Acute toxicity study|on the zebra fish of n-hexylglykol in a static system (96|hours). Project No. 17F0238/915102, dated 04.11.1994|(unpublished study).
Call, D.J. and Geiger, D.L., Subchronic toxicities of|industrial and agricultural chemicals to Fathead Minnows|(Pimephales promelas) Vol. I, Center for Lake Superior|Environmental Studies, Lake Superior Research Institute,|University of Wisconsin-Superior, USA (1992)
Method: other: comp. to OECD 210 (Fish, Early-life Stage Toxicity Test, 1992)
Long-term toxicity to fish, IUC4#1/Ch.4.5.1
Schreiber G (1980a) Bericht ueber die Pruefung von|p-Nitrochlorbenzol auf primaere Hautreizwirkung.|Fraunhofer-Institut für Toxikologie und Aerosolforschung,|March 5, 1980 (at the request of Bayer AG)
Method: other: according to: Code of Federal Regulations, Title 16, Section 1500.41, dee also freetexr ME
Ishidate, M., Primary mutagenicity screening of food|additives currently used in Japan, Fd. Chem. Toxic. 22(8),|623-636, 1984.
Method: other: 1 drop of a 1 % solution in oil was instilled into conjunctival sack
Putman DL (1991). Micronucleus cytogenic assay in the mice. Amended final report. 4,4'-Dichlorodiphenylsulphone 23 May 1991. Microbiological Associates Inc., Laboratory study Number: T8466.122.
Korhonen A, Hemminiki K, Vainio H (1983) Embryotoxicity of|sixteen industrial amines to chicken embryo. J Appl Toxicol|3: 112-117
Fries A.S., Haas U., Jacobsen B.M., Jelnes J.E., Lund S.P. |Simonsen L. (1992). N-methylpyrrolidone effekter pa|fosterudrikling, centralnervesystem, testikler og saed hos|rotter. [Toxic effects of N-methylpyrrolidone on fetal|development, the central nervous system, testes and semen in|rats]. Arbejdmiljofondet, Copenhagen (English summary).
Pupysheva, G.J. & Peresedov, V.P. (1970) cited in Berufs-|genossenschaft der chemischen Industrie. Toxikologische|Bewertung Ausgabe 02/89, Nr. 170 (1989)
Repeated dose toxicity: oral, IUC4#170/Ch.5.4
Dow Corning Corporation (1994) Report No. 1994-I0000-39411
Morey GW, Fournier RO and Rowe JJ (1964). The solubility of|amorphous silica at 25°C. J. Geophys. Res. 69, 1995-2002.
Stasinakis, A.S., N.S. Thomaidis, and T.D. Lekkas. 2001. Toxicity of organotin compounds to activated sludge. Ecotoxicology and Environmental Safety. 49:275-280.
Ram et al. (1988) Aquaculture, 72, 287-293
Durward, R.(2002), Safepharm Laboratories Ltd., N-tert-butylbenzothiazole-2-sulphenamide: Micronucleus test in the mouse, Report No. 1723/004
BASF (1988) Acute toxicity to Leuciscus idus (88/16). BASF|AG, Department of Toxicology, 09.09.1988 (unpublished data)
IITRI. 1992b. Inhalation study of sex-related differences|associated with the respiratory sensitization response of|trimellitic anhydride (TMA): a research project. Final|Report. IITRI Project No. L08100, Study No. 1537, Test|Article No. 128G.
BASF AG, Technical data sheet PRENOL, 05/1999
Ciba-Geigy Ltd., Salmonella/mammalian-microsome mutagenicity|test with TK 10044, 20.4.1977.
WATERNT, 1.01, EPI Suite v.3.11, United States Environmental Protection Agency, 2003.
Mobil International (1977). Imlay P. Acute toxicity of MCTR|191-77: Report on the acute dermal toxicity of rabbits.|Cannon Laboratories Inc., Edison, NJ, Report No. 7E-6994,|Mobil internal report (unpublished report).
Contreras KM, Larsen SJV, and Harris C (1996). Differential|in vitro toxicity of mouse and rat embryos following direct|intra-amniotic exposure to methanol, form-aldehyde and|sodium formate. Abstract. Annual SOT meeting 1995.
Developmental toxicity / teratogenicity, IUC4#9/Ch.5.8.2
Loeser E (1978c). Bayer AG data, Akute orale Toxizität,|Dinintrotoluol X alte Ware, Oktober/30/1978.
CERI (1996). Report No. 91535. Prolonged toxicity test|towards Oryzias latipes. Chemicals Evaluation and Research|Institute of Japan.
Method: other: OECD TG 204 "prolonged toxicity test"
Salmonella typhimurium TA 1535 TA 1537 TA 1538 TA 98 TA 100
BP Chemical Limited London (1995). IUCLID.
Ohno K, Tanaka-Azuma Y, Yoneda Y, Yamada T (2005) Genotoxicity test system based on p53R2 gene expression in human cells: Examination with 80 chemicals. Mutation Research 588:47-57.
Painter, H.A., Water Reseach Pergamon Press, 4, 393-450,|(1970)
International Chemical Safety Cards (ICSC) No.1051,in the|context of cooperation between the International Programme|on Chemical Safety & the Commission of the European|Communities.
CITI (Chemicals Inspection & Testing Institute) (1992).|Biodegradation and Bioaccumulation Data of Existing|Chemicals Based on the CSCL Japan. Japan Chemical Industry|Ecology-Toxicology & Information Center.
Fibroblasten des Chinesischen Hamsters CH1-L
Laham et al., J. Appl. Toxicol. 4, 150-154 (1984)
Repeated dose toxicity: oral, IUC4#60/Ch.5.4
BASF AG, 2002, Product Safety, data assessment, SRC KOWWIN|1.66, 16 July 2002
Method: other (calculated): via SRC KOWWIN 1.66
Hoechst AG (1995): Unveröffentlichte Untersuchung|(LPT-Report No. 8768/94)
Monsanto Chemical Co. (not dated, a) Chronic toxicity and|reproduction studies on Santoflex® 13 and Santoflex ® 77,|unpublished report
Test No. 850213, AUTORADIOGRAPHIC DNA REPAIR TEST ON HUMAN|FIBROBLASTS, CIBA-GEIGY LIMITED, unpublished report
Genetic toxicity in vitro, IUC4#268/Ch.5.5
Degussa-Huls AG (1995) Determination of the acute effects of|DYNASYLAN ATAC On fish (in accordance with EEC 92/69 C 1).|Final Report FK 1338. Degussa-Huls AG Nr.: 95 0221 DGO.|9/19/95.
Epstein, W.C.: Report to RIFM (1980), quoted in: Ford, R.A.|et al.: Fd. Chem. Toxic. 26, 273-416 (1988)
Method: other: according to Kligman, A.M.: J. Invest. Derm. 47, 393 (1966) and Kligman, A.M. and Epstein, W.: Contact Dermatitis 1, 231 (1975)
WHO (World Health Organization). 1991. International|programme on chemical safety - Environmental health criteria|for methyl bromide. First draft, 173-194.
USEPA. 2000. PCKOCWIN, Version 1.66. Soil Adsorption Coefficient. EPIWIN (Estimation Program Interface for Windows). Version 3.11. Office of Pollution Prevention Toxics (OPPTS) and Syracuse Research Corporation (personal communication from C. Staples, Assessment Technologies, Inc., 10/30/04).
Leo, A.J. (1978) Report on the Calculation of |Octanol/Water Log P Values for Structures in |EPA Files (cited in BiblioLine(c) 1997-2007, |NISC International, Inc. All Rights Reserved. www.nisc.com)
Canalstuca,J., Ingeniera quimica (Madrid) 15, 85-88, 1983, No information
Method: other: Adaptation in a model treatment plant
Covance Laboratories (1998). LHS-Super. Skin irritation|study in the rabbit. Unpublished final study report No.|1516/3-1032 dated January 1998. Sponsored by Hydro|Nutrition, Oslo.
Environment Agency Japan (1994): Investigation on the|Ecotoxicological effects of OECD High Volume Chemicals|(Phase 3): p. 1 - 64.
Katritzky AR, Tatham DB, Maran U (2001) Theoretical|descriptors for the correlation of aquatic toxicity of|environmental pollutants by quantitative structure-toxicity|relationships. J Chem Inf Comput Sci 41: 1162 - 1176
Springborn Smithers Laboratories (2006) Resorcinol Acute Toxicity to Freshwater Green Alga, Pseudokirchneilla subcapitata. Study no: 13048.6514, Project no. T05351.
Garner, R.C. and Nutman, C.A. (1977) Mutat. Res., 44, 9-19.
Method: other: Direct plate incorporation
Kubinski H, Gutzke GE, Kubinski ZO (1981) DNA Cell Binding (DCB) Assay for Suspected Carcinogens and Mutagens. Mutation Research 89:95-136.
Stauffer Chemical Company study no. T-4245, 1973.
Method: other: Acute Oral Toxicity Test Guideline
Gorecka-Turska D, Mekler U, Gorski T (1983) Sister chromatid|exchanges in BALB/c mice bone-marrow under the influence of|carcinogenic and non-carcinogenic products and half-finished|products form dyestuff industry (russian). Chem Toksykol 16:|37-42
Bayer AG (1979). Steinhoff D. Chronische UV-Bestrahlung|haarloser Maeuse bei gleichzeitiger kutaner Applikation des|Weisstoeners Blankophor BBH. Study report No. 8390 dated|1979-05-23.
Method: other: testing in presence of UV-radiation, see method
Method: other: as described by Styles, J.A., Br. J. Cancer 36, 558 (1977); see also freetext ME for additional information
Salmonella typhimurium TA100, TA1535, TA98, TA1537|Escherichia coli WP2 uvrA
Method: other: Ames et al. (1975), and Haworth et al. (1983)
Hoechst AG (1981) Unveröffentl. Unters. Ber. 81.0723 Unpublished investigation.
Chapin R. et al., Environm. Health Persp. 105 [Suppl 1],|s 287 (1997)
Method: other: NTP Continuous Breeding Protocol, see also ME
Ullmann's Encyclopedia of Industrial Chemistry., 5th. ed.,|Vol. A1, p.323, 1985, No information
Salmonella typhimurium TA92, TA94, TA98, TA100, TA1535, TA1537
Carreon, R.E., Yano, B.L. and New, M.A. (1981) Peladow|calcium chloride (94-97%): acute toxicological properties|and industrial handling hazards. Unpublished Dow Chemical|Company report.
Gilbert P. et al., Arch. Environm. Contam. Toxicol. 9,|533-541 (1980)
Method: other: OECD guideline 471: plate incorporation method: aerobic and anaerobic condition; fluctuation method
Salmonella typhimurium TA100, TA1535, TA98,|TA1537; Escherichia coli WP2 uvrA
Method: other: 6 rabbits/dose, investigation of the effect on immunological reactivity; in addition to these tests, the effects on the blood were studied
Chemicals Inspection and Testing Institute Japan (1992).|Biodegradation and bioaccumulation data of existing|chemicals based on the CSCL Japan.
Monsanto study MO-77-615A. Biodegradation of Phosphate Esters. (1977)
Method: other: Method similar to OECD 301B
Barbin A, Planche G, Croisy A, Malaveille C, Bartsch H (1978). Detection of electrophilic metabolites of halogenated olefins with 4-(4-nitrobenzyl)pyridine (NBP) or with Salmonella typhimurium. Mutat. Res. 53 (15), 150.
Bayer AG (1985) Internal study: Acute fish toxicity test|with Brachydanio rerio (1985-03-05)
Short-term toxicity to fish, IUC4#110/Ch.4.1
BASF AG, Department of Ecology, unpublished calculation, , Mackay Level I, V 2.11 Model, AOP V 1.87, Hydrowin V 1.64, KOWWIN V 1.60, Dec. 1998
MHW, Japan (1998). Ministry of Health and Welfare, Toxicity|Testing Reports of Environmental Chemicals, 6, 579-591. |(The reverse mutation and in vitro chromosomal aberration|tests were performed by the Hatano Research Institute, Food|and Drug Safety Center.)
Hoechst AG (1982): Unpublished study: Study of the mutagenic|potential of the compound 2-Hydroxynaphthalin-3-carbonsäure|in strains of Salmonella typhimurium (Ames Test) and|Escherichia coli. Report No. 370/82. 16 June 1982
BASF AG, Department of ecology; unpublished report|(10.11.88)
Lide DR (1999) CRC Handbook of Chemistry and Physics 80th|ed. CRC Press Inc., Boca Raton, Florida, page 16-44
Method: other: according to Williams method
Atochem (1987) DNA-binding of 11-aminoundecanoic acid.|Institute of Occupational Physiology, Dortmund, Germany.
BIOFAX Industrial Bio-Test Laboratories, Inc. (1971) Data|sheets. 19-3. In Registry of Toxic Effects of Chemical|Substances. 1999. Sodium acetate. National Institute for|Occupational Safety and Health.[Cited in American Chemistry|Council's (ACC) Acetic Acid and Salts Panel (2003). U.S.|HIGH PRODUCTION VOLUME (HPV) CHEMICAL CHALLENGE PROGRAM -|ROBUST SUMMARIES for CARBOXYLIC FOOD ACIDS AND SALTS|CATEGORY. April 16, 2003.]
Forichon, A. (1992), Hazelton France. Salmonella|typhimurium/Mammalian microsome Plate Incorporation Assay|(Ames Test), Report number 203301. Conducted for Wacker|Chemie GmbH, 18 August, 1992.
Tanooka H (1977): Development and Applications of Bacillus|Subtilis Test Systems for Mutagens, Involving DNA-Repair|Deficiency And Suppressible Auxotrophic Mutations. Mutation|Research 42, 19-32
Sax NI: Dangerous Properties of Industrial Materials. 6th|ed., New York, 1986
Monsanto Study SA-85, Dec. 1954, Scientific Associates Lab. as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Short-term toxicity to fish, IUC4#28/Ch.4.1
Clariant GmbH, (1988) Unpublished testing report titled|"o-Chlorbenzylchlorid D, Prufung der akuten Toxizitat am|Fisch Zebrabarbling (Brachydanio rerio) uber 96 Stunden",|Report No.: 88.1592, 7.10.1988, conducted by HOECHST AG,|Pharma Forschung Toxikologie.
Hasegawa, R. et al.: Sci. Rep. Res. Inst. Tokoku University|Ser. C Med. 36 81-4), 10-16 (1989);|cited in: RIFM database, location no. 28562
Downs, A.M.R. et al. (1998), Contact sensitivity in patients|with oral symptoms, Contact Dermatitis, 39, 258-259
BASF (2001) In vitro micronucleus assay with mucochloric|acid techn. pure in V79 cells, Report No.: 33M0345/994185.|BASF AG, Product Safety (unpublished data)
Method: other: Draft OECD guideline 1998 (see freetext)
TNO: Central Insitute for Nutrition and Food Research,|Report No. 3489, Juni 1971
Withers R.M.J. and Shaw J.P.H., Mod. Chlor-Alkali Technol.,|4, 51-61 (1990)
Acute toxicity: inhalation, IUC4#22/Ch.5.1.2
CERI (1996). Report No. 91531. Growth inhibition test with|Selenastrum capricornutum. Chemicals Evaluation and Research|Institute of Japan.
Shaver TN (1984). Fate of Ethephon and N-methyl-2-pyrrolidone in Soil and Cotton Plants. Arch.|Environ. Contam. Toxicol. 13, 335-340.
Method: other: USA Cotton Insects Res. Lab.
Allen SE in Hauck RD (ed.): Nitrogen in Crop Production, pp.|195-206. Am. Soc. Agron., Madison, Wisc. 1984. Cited in:|Reddy KS and Menary RC: Effects of nitrogen source, rate and|application time on boronia (Boronia megastigma Nees) leaf|nitrogen and flower production. Fertilizer Res. 19, 169-174,|1989.
Clariant GmbH (1999): Calculation of Log Kow, SRC LOGKOW|v1.51
Auer-Technikum, Auerges. mbH Berlin, 12. Ausg. 1988
Parry J.M. et al.: Mutat. Res. 61, 37-55 (1979);|cited in: Zimmermann, F.K. et al.: Mutat. Res. 133, 199-244|(1984)
Chellman, G.J., Bus, J.S., and Working, P.K.: Proc. Nat. |Acad. Sci. 83(21): 8087-8091 (1986a).
Ciba-Geigy Ltd., Report on the test for ready|biodegradability of TK 10044 in the Modified Sturm test,|Project No. 840054; 02.05.1984.
Industrial Biology Laboratories Inc, Shelanski MV (1963 a)|Human patch test. Study report Project No. SH-63-5.|Unpublished study of Monsanto Chemical Co
Leifer Z, Hyman J, Rosenkranz HS (1987) Determination of|genotoxic activity using DNA polymerase-deficient and|-proficient E.coli. Short Term Tests. Chem Carcinog 127-139
Method: other: standard disc diffusion assay according Slater et al. (1971) and Rosenkranz and Leifer (1979)
Genetic toxicity in vitro, IUC4#81/Ch.5.5
Method: other: 12 week old rats, S-phase was measured in primary hepatocytes 24 and 48 hrs after treatment
Method: other: Inhalation Hazard Test, see also freetext TC
ECB (2006). European Chemical Bureau. ESIS (European|chemical substances information system). Formic acid, CAS#|64-18-6. Availabe at http://ecb.jrc.it.
Walker JD (1989) Effects of chemicals on microorganisms:|Fate and effects of pollutants. J Water Pollut Control Fed|61 (6): 1077 - 1095
Longstaff, E., Robinson, M., Bradbrook, C., Styles, J.A. and|Purchase, I.F. Genotoxicity and carcinogenicity of|fluorocarbons: assessment by short-term in vitro tests and|chronic exposure in rats. Toxicol Appl Pharmacol, Vol 72,|15-31, 1984.
Ishidate, M. et al.: Fd. Chem. Toxic. 22, 623-636 (1984)
Ministry of Health & Welfare, Japan (1999d): Toxicity Testing Reports of Environmental Chemicals, vol 7, 247-256, "Combined Repeat Dose and Reproduction/Development Toxicity Screening Test of 2,4-Diamino-6-phenyl-s-triazine by Oral Administration in Rats"
Method: other: OECD TG 422: combined repeat dose and reproductive/developmental toxicity screening test
Zahn, Wellens. 1980. Z. Wasser Abwasser Forsch. 13, 1-7
Method: other: Standversuch nach Zahn-Wellens, DIN 38412 Teil 25 [Conditions according to Zahn-Wellens, DIN 38412 Part 25]
Method: other: experimental, not specified
Perstorp (2003). Material safety data sheet according to|2001/58/EC. Calcium formate, reviewed on 18 Nov 2003.
Interactive Analysis Program (http://www.logp.com)
Method: other (calculated): Interactive Analysis Program
Hazleton Laboratories America, Inc: Project No. 2088-105,|31.07.1981
Bayer AG, Loeser E (1978) o-Toluidin Untersuchungen zur|akuten Toxizität unpublished investigations, November 09,|1978
Erexson, L.G.: In vivo mouse micronucleus assay with |2,2'-thiodiethanol. Covance study no. 22283-0-455OECD,|Covance Laboratories Inc., Vienna, VA, 2001; submitted to|U.S. Army Center for Health Promotion and Preventive|Medicine, Aberdeen Proving Ground, MD
Method: other: OECD Guide-line 474, 1997
Harris C, Dixon M, and Hansen JM (2004). Glutathione|depletion modulates methanol, formaldehyde and formate|toxicity in cultured rat conceptus. Cell Biology and|Toxicology 20, 133-145.
Carpenter, C. P. et al.: J. Ind. Hyg. Toxicol. 31: 343-346|(1949)
BASF AG. 1985. Unveröffentl. Unters. des Labors Ökologie [Unpublished investigations of the ecology laboratories] (Ber. vom [report from] 18.03.1985)
Method: other: Standversuch nach Zahn-Wellens [Test conditions according to Zahn-Wellens]
Hüls AG (1989). Verteilungskoeffizient n-Oktanol-Wasser|(Pow-Wert) für "Altstoffe". Internal communication|3610-15/ka of 10 January 1989 (unpublished).
Method: other (calculated): CLOGP3 Computer program, MedChem Project, Pomona College
Dow Corning Corporation Internal Report Number|1982-I0005-963.
Kramer JB (1992). Fluorescent whitening agents. In:|Hutzinger O (ed.). The Handbook of Environmental Chemistry|3F, 351-366. Springer-Verlag, Berlin Heidelberg.
Biodegradation in water: screening tests, IUC4#190/Ch.3.5
ASTM. 2000. Standard practice for conducting acute toxicity|tests with fishes, macroinvertebrates and amphibians.|Standard E729-96. American Society for Testing and|Materials, 100 Barr Harbor Drive, West Conshohocken, PA|19428.
Salmonella typhimurium TA98, TA1535, TA1537, TA1538, TA100
Method: other: ECOSAR Computer Model (in:EPIWIN)
Mittler, S. et al.: Nature 214, 424 (1967);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Bal'yan VV, Petrosyan FR, Gizhlaryan MS (1983). Influence of 1,4-dichlorobutene on the generative function of experimental animals. Biol. Zh. Arm. 36, 663-667.
Serjeant EP, Dempsey B (1979) Ionisation constants of organic acids in aqueous solution. IUPAC Chemical Data Series No. 23. New York, NY, Pergamon Press pp. 989 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Awogi T, Itoh T, Tsushimoto G (1986) The effect of benzene|and its derivates on metabolic cooperation. Mut Res 164: 263
FMC Corporation, Sodium persulfate: acute inhalation|toxicity study in rats, Study no. I95-2017, 1995.
CD Römpp Chemie Lexikon - Version 1.0, Stuttgart/New York:|Georg Thieme Verlag 1995, No information
BASF AG (1986). Department of Ecology, report No. 01.456 (unpublished).
BOD5 Method: other: according to the German Industrial Standard DIN 38409, Part 51
BUA (2005): Benzenesulfonic acid,|2,2'-(1,2-ethenediyl)bis[5-[[4-(4-morpholinyl)-6-(phenylamin|o-1,3,5-triazin-2-yl]amino]-, disodium salt. Calculation of|log Pow with SRC-KOWWIN v1.67 (2000).
Noack U (1995c). Laboratorium für angewandte Biologie.|Respiration inhibition test of tungsten carbide (WC) HCST|product designation WC DS 100 with activated sludge. Study|No. BBR42411.
Ciba-Geigy Ltd., Nucleus anomaly test on somatic interphase|nuclei, TK 10044, Chinese hamster, 22.9.1976.
Silicone A-1120: Eight Rabbit Skin Inunctions During 19|Calendar days; Carnegie-Mellon Institute of Research;|Special Report 38-102; August 13, 1975.
TNO (1969). Sub-chronic (90-day) Toxicity Study with TA 1201|in Rats. Central Institute for Nutrition and Food Research,|Zeist. Unpublished re-port # R 2919. June 1969.
Salmonella typhimurium TA98, TA100, TA 1535)
Scott, M.J. et al.: Environ. Mutagen. 7, 53-54 (1985);|abstract, No information
Genetic toxicity in vivo, IUC4#41/Ch.5.6
Safepharm Laboratories. 1992. Assessment of the algistatic|effect of diethylene glycol monobutylether to Scenedesmus|subspicatus. Project Number 222/46, dated May 19, 1992|(unpublished study).
Method: other: OECD Guide-line 201 and EEC Commission Directive 87/302/EEC
Eastman Kodak Company (1980) data, March 27, 1980; NTIS/OTS 0006567, Doc ID. 878214424 (1984)
Method: other (measured): OECD TG104 (Gas saturation method)
Atochem NA, Inc. Monobutyltin Trichloride: Assessment of Clastogenic Action on Bone Marrow Erythrocytes in the Micronucleus Test. Final Report 91/AMT003/0356. Study conducted by Life Science Research Ltd. 04.06.1991.
Bergman HL, Anderson AD (1977) Effects of Aqueous Effluents from In Situ Fossil Fuel Processing Technologies on Aquatic Systems. Contract No. EY-77-C-04-3913, University of Wyoming, Laramie, WY (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Wuhrmann K and Woker H (1958) Verh Int Ver Limnol, 13,|557-583
Method: other: Aquatic arthropod toxicity test
Short-term toxicity to aquatic invertebrates, IUC4#25/Ch.4.2
BASF AG (2003). Department of Ecology, Bacterial Oxygen Consumption Test, summary reprint from unpublished Report 10/1165/88 (10 April 1989), 10 November 2003.
Method: other: DIN 38412 part 27 (Draft) (1988)
Rusakov NV, Korotkova GI, Biklubatov VS (1973)|Experimentelle Untersuchung der allergenen Wirkung von|Ortho- und Para-nitrochlorbenzol. Gig Sanit 3: 13-16
Method: other: 3 drops (10 % sol.) to the clipped area of the skin; 22nd day inj. of Freund-adjuvans and TS into the hind paw (0.5 mg/kg bw), d28 1 drop (10 % sol.) to an untreated clipped area of the skin; reading time not mentioned
Method: other: test procedures followed those recommended by EPA and ASTM
Bayer AG, Steinhoff D, Dycka (1981) Vergleichende|Kanzerogenese Versuche mit 2,4-Toluylendiamin,|2,4/2,6-Toluylendianin 80/20, m-Phenylendiamin, o-Toluidin,|p-Toluidin, 4,4'-Diaminodiphenylnethan, Benzidin, bei|subkutaner Applikation an Ratten. Unpublished report No|10682, July 06, 1981
Schultz TW (1999). Structure-toxicity relationships for|benzenes evaluated with Tetrahymena pyriformis. Chem. Res.|Tox. 12, 1262-1267.
Method: other: Population growth impairment assay
US Pharmacopeial Convention, US Pharmacopeia, the National|Formulary, 22nd ed, Rockville, MD, 204-205 (1990)
Carpanini FMB, Gaunt IF, Hardy J, Gangolli SD, Butterworth|KR, Lloyd AG (1978) Short-term Toxicity of Allyl Alcohol in|Rats, Toxicology 9, 29-45
Bringmann,G., Kuehn,R., Zeitschrift fuer Wasser- und|Abwasser-Forschung, 10(5), 161-166, (1977)
Karamysheva, A. V.: Toks. Vest. 4, Jul-Aug, 40,(1998)
Method: other: (calculated) BCF Program (v2.13)
Method: other: application in trioctanoin
Green FJ (1990). The Sigma-Aldrich Handbook of Stains, Dyes|and Indicators, Aldrich Chemical Company, Inc., Milwaukee,|Wisconsin.
Solubility in organic solvents / fat solubility, IUC4#4/Ch.2.6.1
Hoechst AG (1993): EG-Sicherheitsdatenblatt Natriumsulfit,|wasserfrei (22.05.1993)
Boehringer Ingelheim KG, DIN Safety Datasheet (1994)
Doolittle, D.J. and Butterworth, B.E.: Carcinogenesis 5,|773-779 (1984), No information
Genetic toxicity in vitro, IUC4#170/Ch.5.5
Wehner K, Burk W, and Kisan W (1977).|N-Methyl-epsilon-caprolactam - ein neues|Selektivlösungsmittel zur Gasentsäurerung. Chem. Techn.|29(8), 445-448.
Dow Chemical Company (1999). Dowanol PPH Glycol Ether MSDS (Material Safety Data Sheet).
National Cancer Institute (NCI) (1996) NTP Technical Report|on Comparative Toxicity and Carcinogenicity Studies of|o-Nitrotoluene and o-Toluidine Hydrochloride. Technical|Report Series No. 44. NIH Publication No. 96-3936.
Method: other: comparative toxicity and cancerogenicity
Mohr, U. et al.: Fd. Chem. Toxic. 22, 377-382 (1982); and|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Mamedov A (1979). Response of lymphoid tissue to single and|multiple inhalation exposures to isoprene and some relevant|integral indices, AM Gigiena Truda I Professional'Nye|Zabolevaniya, Vol. 6, pp. 34-37.
Repeated dose toxicity: inhalation, IUC4#27/Ch.5.4
Reported in Du Pont, Haskell Laboratory, Internal DMAC|Review, Oct. 1988 from Arnold D. et al. (1972). Industrial|Bio-Test Laboratories, Inc., Report IBT-E582A
Kato, F. et al.: Mutat. Res. 216, 366-367 (1989); abstract|no. 23, No information
Method: other: Bacterial reverse mutation assay
Hommel: Handbuch der gefährlichen Güter, Springer-Verlag|Berlin Heidelberg 1970, 1974, 1980 und 1987, Merkblatt 51.
Stom DI, Geel TA, Balayan AE (1986) Effect of Individual Phenolic Compounds and of Their Mixtures on Luminous Bacteria. Part 3. Combined Action of Phenolic Compounds on Aquatic. Acta Hydrochimica et Hydrobiologica, 14(5): 539-549 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved.|www.nisc.com)
BASF (1998) Department of Ecology, 20.12.1998 (unpublished|data)
RTECS, update 9301 (through July 1993): Drugs in Japan|(Ethical Drugs) 6, 174 (1982)
Akzo Chemicals BV (1989) Biodegradability of Methyl Ethyl|Ketone Peroxide. Akzo Chemicals BV. Study/Project#: CRL|F89118; Project T89-6-1.9. Study Date: 11/30/89.
JT Baker (2008) Material Safety Data Sheet on Resorcinol. http://www.jtbaker.com/msds/englishhtml/r3900.htm.
Genetic toxicity in vitro, IUC4#208/Ch.5.5
MITI (Ministry of International Trade and Industry)(1992)|Biodegradation and Bioaccumulation Data of Existing|Chemicals Based on the Chemical Substances Control Law|(CSCL). Japan. Chemicals Inspection and Testing Institute|(CITI, ed.); Japan Chemicals Industry Ecology-Toxicology and|Information Center 3-41
Rohm and Haas Co. 1978. Extended Acute Oral LD50 Studies of Nine Samples. Study conducted by Hill Top Toxicology for Cincinnati Milacron. Ref. 77-1094-21. 25.5.1978.
Method: other: Regulations for the Enforcement of the Federal Hazardous Substances Act (CFR, Title 16, Chapter 11, 1976)
Method: other: see reference for details
Gunnatilleka, A.D. & Poole, C.F.: Anal. Commun. 36(6),|235-242 (1999)
Noguera DR and Freedman DL (1997). Characterization of|products from the biotransformation of 2,4-dinitrotoluene by|denitrifying enrichment cultures. Water Environ. Res. 69|(3), 260-268.
Method: other: Batch degradation experiment
Salmonella typhimurium TA100, TA1535, TA98, and TA1537
Wilde, E., Soracco, R., Mayack, L. et al. (1983): Acute|toxicity of chlorine and bromine to fathead minnow and|bluegills. Bulletin of Environmental Contamination and|Toxicology, 31, 309-314.
Method: other: American Public Health Association (APHA) (1980). Standard methods for the examination of water and wastewater. 15th Ed. Washington, D.C.
Nakatsugawa, T. and Nelson, P. A. Studies on insecticide detoxication in invertebrates; an enzymological approach to the problem of biological magnification, in "Environmental Toxicological of Pesticides", edited by Matsumura, F. et al., Academic Press, New York and London, pp. 501-524, 1972
Method: other: acc. to OECD guideline 408
McCann J, Choi E, Yamasiki E, Ames BN (1975) Detection of|carcinogens as mutagens in the Salmonella/microsome assay of|300 chemicals. Proc Nat Acad Sci USA 79: 5135-5139
BASF AG, 1988, Department of Product Safety, Laboratory of|Toxicology, Acute toxicity of choline chloride (50% powder)|to the Golden Orfe, unpublished data, 10F0664/875285, 17|March 1988
Method: other: according to DIN 38412 Part 15
Bayer AG (2006) Micronucleus Test. Rpt T0076485 (Unpublished data).
Zahn,R., Wellens,H., Chemiker-Zeitung 98(5), 228-232, (1974)
Method: other: BOD5-Bottle-Test; DEV H 5 (BSB des CSB)
Votko, et al. (1972) Chem. Zvesti, 26, 460
Method: other: Methods for Acute Toxicity Tests with Fish, Macroinvertebrates and Amphibians (EPA, 1987)
Cir (1992) J. Am. Coll. Toxicology 11, 423.
Kanta, S. and Sarma, T.A. (1980) Biochemical studies on|sporulation in blue-green algae. II. Factors affecting|glycogen accumulation. Zeit. Allg. Mikrobiol., 20(7),|459-463.
Dearman RJ, Spence LM and Kimber I (1992). Characterization of murine immune responses to allergenic diisocyanates. Toxicol. Appl. Pharmacol. 112, 190-197.
ITC/USEPA (1980) Information Review #213(Draft) Alpha Chloroalkenes, p.3
BASF AG, Material Safety Data Sheet Isobutylacrylat. July|26, 2001
Method: other: Detection of aberrant crypt foci (ACF) and intestinal tumours after initiation with 1,2-dimethylhydrazine and treatment with test substance
Sklyar, V., Mosolowa, T.P., Kucherenko, I.A., Degtyarova,|N.N., Varfolomeyev, S.D., Kalyuzhnyi, S.V.: Anaerobic|toxicity and biodegradability of hydrolysis products of|chemical warfare agents. Appl. Biochem. Biotechn. 81,|107-117 (1999)
Huels AG (1989). Unpublished study report #1579. Cited in:|ECB IUCLID 2000.
Method: other: according to Ames et al.,Proc Natl Acad Sci USA,70 (1973)
Genetic toxicity in vitro, IUC4#35/Ch.5.5
Weast, R.C. (1979). Handbook of Chemistry and Physics.|60th Ed., CRC Press Inc., Boca Raton, Florida, C-84.
de Vogel, N. 2003. Tetraoctylstannane [CAS# 3590-84-9]: Micronucleus test in bone marrow cells of mice. Report V4404/05. Department of Biomolecular Sciences, TNO Chemistry, 3700AJ Zeist, the Netherlands. 2 April 2003.
Lu G-H, Yuan X, Zhao YH (2001). QSAR study on the toxicity|of substituted benzenes to the algae (Scenedesmus obliquus).|Chemosphere 44, 437 - 440.
Pitter, P. Determination of Biological degradability of Organic Substances. Water Research. 10, 231-235, 1976
Doe JE et al. (1983) Toxicol Appl Pharmacol, 69, 43-47.
Mabey, W. and Mill, T.: Phys. Chem. Ref. Data 7:383-415|(1978).
Koppers Company (1962) Range Finding Toxicity Tests on Flaked Grade Resorcinol; Industrial Hygiene Foundation of America Inc., Oct-Dec 1962.
Bayer AG 2002, Calculation of | - Log Octanol-Water Partition Coefficient with SRC-KOWWIN|v.1.66, 2000| - Henry´s Law Constant with SRC-HENRYWIN v.3.10, 2000| - Indirect Photodegradation with SRC-AOPWIN v.1.90, 2000| - Soil Adsorption Coefficient with SRC-PCKOCWIN v.1.66,|2000| - Volatization from water with EPIWIN 3.10
Method: other (calculated): with SRC-AOPWIN v1.90 (2000)
Solubility in organic solvents / fat solubility, IUC4#10/Ch.2.6.1
Method: other: according to modified OECD screening test (OECD Guide-line 301 E)
Biodegradation in water: screening tests, IUC4#32/Ch.3.5
Bayer AG data, Report No. 19466, August 30 (1990)
Darroudi F, Natarajan AT (1985) Cytostatic drug activity in|plasma, a bioassay for detecting mutagenicity of directly|and indirectly acting chemicals, an evaluation of 20|chemicals. Mut Res 143: 263-269
Method: other: Induction of SCE in CHO cells treated with plasma of rats pretreated with o-Toluidine
Genetic toxicity in vitro, IUC4#122/Ch.5.5
Wei C., Tan H., Fernando S.Y. and Ko N.-J., 1986, Inhibitory|effect of beta-ionone on growth and aflatoxin production of|Aspergillus parasiticus on peanuts, J. Food Protection 49,|515-518
Geuther A (1872). Ueber die Zersetzung des Phosphorchloruers|durch Wasser. Ber. Liebig's Ann. 5, 440-445.
Thymidine kinase (TK) locus of L5178Y tk+/- mouse lymphoma cells
Hoechst AG (1996). EG-Sicherheitsdatenblatt Benzotrichlorid|TTR. 1996-01-10.
Plassche EJ van de; Bont PFH, Hesse JM (1999). Exploratory|Report Fluorescent Whitening Agents (FWAs). National Inst.|of Public Health and the Environment, P.O. Box 1 NL-3720|Bilthoven, The Netherlands, Report No: 601503013; May 1999.
Bolognesi C, Cesarone CF, Santi L (1980) L'induzione della|eluibilata in alcali del DNA. Boll Soc It Biol Sper 56:|2480-2485
Method: other: alkaliche elution according to Cesarone et al., 1979, Anal. Biochem.100, 188-197
Biospherics Inc. Unpublished report, (1985)
Bayer Industry Services (2004f). Bacteria Toxicity of 1,4-Dichloro-2-butene. Unpublished Report, No. 1326 A/04 B.
Method: other: Directive 88/302/EEC, C.11 in most parts identical with OECD TG 209
Leung, H.W. and Auletta, C.S. (1997) Evaluation of skin|sensitization and cross-reaction of nine alkyleneamines in|the guinea pig maximization test. J Toxicol-Cut & Ocular|Toxicol 16:189-195.
Covance Laboratories (2002). Formi LHS. 80 week oral|(dietary administration) oncogenicity study in the mouse. |Unpublished final study report No. 1516/33-D6154 dated|December 2002. Sponsored by Hydro Nutrition, Oslo.
Smart PL (1984). A review of the toxicity of twelve|fluorescent dyes used for water tracing. NSS Bulletin 46,|21-33.
Monticello, T.M. et al.: Toxicol. Appl. Pharmacol. 111,|409-421 (1991), No information
Repeated dose toxicity: inhalation, IUC4#71/Ch.5.4
Huels AG (1993), unpublished report PZ-93/09. Bestimmung der|Bakterientoxizität von Malonsäurediethylester im|Pseudomonas-Zellvermehrungs-Hemmtest (DIN 38412 Teil 8)|Degussa AG-Reg-Nr.: 93-0232-DGO
Basketter, D.A. and Scholes, E.W.: Fd. Chem. Toxicol. 30,|65-69 (1992), No information
Schafer, Jr., E.W. and W.A. Bowles, Jr. 1985. Acute oral toxicity and repellancy of 933 chemicals to house and deer mice. Archives of Environmental Contamination and Toxicology. 14:111-129.
Ministry of Environment, Japan (1999b): unpublished report on acute toxicity to daphnids
Method: other: SRC WSKOW v1.40 Computer Program, integrated in U.S. EPA's EPI program Vers. 3.10
GAF Corp.: M-Pyrol, Summary of Toxicity Information, July|1986
Repeated dose toxicity: dermal, IUC4#24/Ch.5.4
RTECS, update 8912: Gig. Truda. i Prof. Zabol. 27(5), 60|(1983)
Verschueren K (1996). Handbook of Environmental Data on|Organic Chemicals (3rd ed.). Van Nostrand Reinhold, New|York, 1735-1737.
Hilscher H. et al.: Acta Biol. Med. Germ., 23, 843-852, (1969) as cited in IUCLID.
B.F. Goodrich 1984. Evaluation of TBBS (BBTS) in the CHO/HGPRT assay as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
DuPont (1994). Toxicity summary 1,4-dichlorobutene-2. Haskell Laboratory, Report from February 28, 1994.
Barrow, C., Kociba, R., Rampy, L. et al. (1979): An|Inhalation toxicity study of chlorine in Fischer 344 Rats|following 30 days of exposure. Toxicology and applied|Pharmacology, 49, 77-78.
Leo AJ. (1978) Report on the calculation of octanol/water|log P valves for structures in EPA files.
BASF AG (2007). Report on the determination of the chronic|effect on the reproduction of the water flea Daphnia magna|Straus. Department of Experimental Toxicology and Ecology,|Ludwigshafen/Rhein, Germany, Project No: 51E0274/073100, 12|Oct 2007 (unpublished).
Hshieh (1997) Fire and Materials 21:277-282
Smith EN and Taylor RT (1982). Toxicology 25, 271-287. Cited|in: ECB IUCLID 2000.
Gray, L.E. jr. and Kavlock, R.J.: Teratogen. Carconogen.|Mutagen. 4, 403-426 (1984)|cited in: RIFM database, location no. 2291
Gupta RL, Kaur IP, Gupta AK, Pathak DP and Juneja TR (1989)|Effect of norharman on the mutagenicity of toluidine|metabolites. Toxicol Lett 48: 75-81
Method: other: according to Maron et al., Mutat. Res. 113, 173 (1983)
U.S. EPA (Environmental Protection Agency) (2004b). High|Production Volume Challenge Program (HPV), Robust Summaries|and Test Plans: Allyl Alcohol, 201-14921B
Method: other (calculation): SRC-PCKOCWIN v 1.66
CIBA-GEIGY, Ltd. 1975. Skin sensitizing (contact allergenic) effect in guinea pigs of TK 11692. Project No.: Siss 3985. 2.7.1975.
Hoshi A, Yanai R, Kuretani K. (1968) Toxicity of|terephthalic acid Chem Pharm Bull 16 1655-1660
Bringmann,G., Gesundheits-Ingenieur 94(12), 366-369, 1973, No information
Method: other: Modification of DEV L8 (1960)
Lapota, D., D.E. Rosenberger, M.F. Platter-Rieger, and P.F. Seligman. 1993. Growth and Survival of Mytilus edulis Larvae Exposed to Low Levels of Dibutyltin and Tributyltin. Marine Biology. 115:413-419.
Ganz CR, Liebert C, Schulze J, Stensby PS (1975). The|removal of detergent fluorescent whitening agents (FWAs)|from influent water during sewage treatment. J. Water|Pollut. Control Fed. 47, 2834-2849.
Lonza AG, unpublished report, 1992, Niacin: Teratology study in rat, Lonza Report No. 913
Cryer A., Bartley W., Studies on the adaptation of rats to a|diet high in glycerol, Int. J Biochem 4:293-308, 1973 (38).
Ishidate M, Harnois MC, Safini T. (1988) A comparative|analysis of data on the clastogenicity of 951 chemical|substances tested in mammalia cell cultures. Mutat Res 195,|151-213
Hoechst AG (1976): Unpublished report (15.03.1976)
Biodegradation in water: screening tests, IUC4#57/Ch.3.5
Boman, A. et al.: Sensitizing potential of dicyanodiamide,|Contact Dermatitis, 13-3, 189(1985)
Yoo YS (1986). Mutagenic and antimutagenic activities of|flavoring agents used in foodstuffs. Journal of Osaka City|Medical Center, 34, 267-288.
Method: other: Ishii Y and Kondo S (1975). Mut. Res. 27, 27-44; Brusick DJ et al. (1980). Mut. Res. 76, 169-190
Hill Top Research, Inc. 1971. Report: VA-38A. Acute Toxicity and (Skins) Irritation Studies on Sample SW-81003. 12.3.1971.
Method: other: Federal Hazardous Substances Act (191.11)
Short-term toxicity to aquatic invertebrates, IUC4#120/Ch.4.2
Zwart A. and Woutersen R.A. (1988): Acute Inhalation|toxicity of chlorine in rats and mice:|time-concentration-mortality relationships and effects on|respiration. J. Hazard. Mat., 19, 195-208.
Ramos EU, Vaes HJ, Verhaar HJM, Hermans JLM (1998) J Chem|Inf Comput Sci 38: 845
Dyer HM, Kelly MG, Dunn TB (1946). Effect of administration|of hot water, acids, alkali, mecholyl chloride, or atropine|sulfate upon the gastric mucosa of mice. J. Natl. Cancer|Inst. 7, 67-70.
Price KS, Waggy GT, and Conway RA (1974). Brine shrimp|bioassay and seawater BOD of petrochemicals. J. Water|Pollut. Contr. Fed. 46(1), 63-77.
Method: other: BOD of THOD (closed bottle test)
Amoco Chemicals Co. (1990) Acute Dermal Toxicity Study of |Terephthalic Acid in Rabbits. Test Study Reference:|IITRI SN 1558, TA# 445F
Hannah SA, Austern BM, Eralp AE and Wise RH (1986).|Comparative removal of toxic pollutants by six wastewater|treatment processes. J. Water Pollut. Control Fed., 58,|27-34.
Litton Bionetics, Inc. (1975). Mutagenic evaluation of|compound FDA 75-5 000527-07-1 sodium gluconate, FCC, Fine|granular. Submitted to Food and Drug Administration|Department of Health, Education and Welfare, Rockville,|Maryland.
Passino, D.R.M. & Smith,S.B., Acute Bioassays and hazard|evaluation of represantative contaminants detected in Great|Lakes fish. Env. Tox. Chem. 6, 901-907 (1987)
Method: other: ASTM E729-80: Standard practise for conducting acute toxicity tests with fish, macroinvertebrates and amphibians (1980)
Smith CJ, Perfetti TA, Garg R, Martin P, and Hansch C|(2004). Percutaneous penetration enhancers in cigarette|mainstream smoke. Food and Chemical Toxicology 42, 9-15.
Method: other (calculated): C-QSAR program
Union Carbide Corp., Unpubl. Data; zitiert in cited in: Rowe & Wolf (1982): Patty's Ind. Hyg. Toxicol., Vol. 2C, 3rd Ed., 4028-4029
Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA1538, G46, C3076, D3052
Hanstveit, R. 2003. Determination of the ready biodegradability of dichlorodioctylstannane in a Manometric Respiration Test. TNO Report No. V2497/01. June 2003.
Syrian hamster embryo fibroblasts (SHE-cells)
Atkinson,R., Journal of Physical and Chemical Reference Data|Mongraph No 2, p.118, 1992, No information
Lanxess (2007). Info on calcium formate. Personal communication to ACC, unpublished, 26 Feb 2007, updated 06 Jun 2007.
FMC Corporation, Acute and 28-day subacute toxicity of|sodium persulfate, Study no. ICG/T-79-029, 1979 (18).
Thomann P and Maurer T. Skin sensitization (contact|allergenic) effect in Guinea pigs of FAT 65'023/E. Report|Exp. No. 75/34, December 11, 1975.
Method: other: guinea pig optimisation test
Occupational Health Service center.(1976), Unpublished|report
Nixon, G.A. et al. (1975): Toxic. Appl. Pharmacol. 31, 481;|cited in BIBRA Toxicity Profile 1990.
CIT (1993) Acute dermal toxicity in rats -|Isooctylthioglycolate, Centre International de Toxicologie,|Report no. 10269 TAR, December 1993.
Monsanto Co (1980-1984) Unpublished data: cited in ACGIH|(1986) Documentation of TLVs, 5th ed., pp. 432.1-432.2
OECD Guideline 475 (Mammalian Bone Marrow Chromosome Aberration Test)
Daubert, T.E.(1989), Physical and Thermodynamic Properties of Pure Chemicals Data.
Reported in AIDA (13/11/92)-ALSTOFF INFORMATION Date Bank|from BASF AG (1988), Ecological Laboratory-Unpublished Data.
MOE Japan (1999). Ministry of Environment, Toxicity study of|choline chloride on Daphnia magna, unpublished study, No.|1998-14
Mitsubishi Chemical Safety Institute Ltd. (2002b). Growth|inhibition test of sodium gluconate with Algae (Selenastrum|capricornutum). Study Number A010389. Study sponsored by|Fujisawa Pharmaceutical Co., Ltd.
Kirk-Othmer Encyclopedia of Chemical Technology. (1993) |Knoschwitz, J.I (ed). Vol 8:76 John Wiley & Sons. New|York, New York
Bringmann, G.; Kuehn, R.; Gesundheits - Ingenieur, vol. 4,|115 - 120 (1959).
MacPhee C, Ruelle R (1969) Lethal Effects of 1888 Chemicals|upon Four Species of Fish From Western North America. Univ|Idaho Forest, Wildl Range Exp Station Bull No 3, Moscow, ID,|pp 112
Palitti, F. et al., Prog. Mutat. Res. 5, 443-450 (1985)
Hansch C and Leo A (1979). Substituent Constants for|Correlation Analysis in Chemistry and Biology. John Wiley &|Sons, New York Chichester Brisbane Toronto 1979, 213.
Lonza AG, unpublished report, 1985, Ames Test, Inveresk Research, Lonza Report No. 1944
Hommel: Handbuch der gefährlichen Güter, Springer-Verlag|1970, 1974, 1980 und 1987, Merkblatt 51.
Short-term toxicity to fish, IUC4#17/Ch.4.1
Clark, S.L. & Donner, M. E.: Mouse lymphoma mammalian|mutagenesis assay. Integrated Laboratory System, Durham,|N.C.; Project No. A083-001, Contract No. DAAD05-91-C-00018,|31 July 1998; submitted to U.S. Army Center for Health|Promotion and Preventive Medicine, Aberdeen Proving Ground,|MD
Method: other: OECD Guide-line 476, 1997
Infracor GmbH, Degussa Group (2002). Determination of|biodegradability in the modified Sturm test. Report No.|ST-182/01 (unpublished)
Shimizu M, Yasui Y, Matsumoto N (1983) Structural|specificity of aromatic of aromatic compounds with special|reference to mutagenic|activity in Salmonella typhimurium - a series of chloro- or|fluoro-nitrobenzene derivatives. Mutat Res 116: 217-238
Method: other: According to Ames et al., Proc. Natl. Acad. Sci (USA) 70: 782 (1973), pour-plate method, solvent: DMSO, performed in duplicate and repeated at least 3 times, solvent control, pos. Controls (ENNG, 2-NF, 9-AA)
Geiger D.L., Call D.J. and Brooke, L.T., 1988, Acute|toxicities of organic chemicals to fathead minnows|(Pimephales promelas), Vol. IV. Center for Lake Superior|Environmental Studies, University of Wisconsin.
Method: other: according to US EPA Committee on Methods for Toxicity Tests with Aquatic Organisms (1975)
Solubility in organic solvents / fat solubility, IUC4#9/Ch.2.6.1
Salmonella typhimurium TA97, TA98, TA100, TA1535, TA1537
Method: other: OECD 204: Fish, Prolonged Toxicity Test: 14-day Study (4 April 1984)
MITI, Japan (1994b) Unpublished Report (HPV/SIDS Test|conducted by MITI, Japan. Test was performed in Chemicals|Inspection and Testing Institute, Japan)
Petrosyan FR, Bal'yan VV, Gizhlaryan MS (1982). Effect of 1,4-dichlorobutene on the system mother-placenta-fetus. Biol Zh Arm 35, 380-384. Cited in: Chemical Abstracts 97, 105183t.
Huntingdon Life Sciences Ltd. (2003c). Acute Toxicity to|Daphnia Magna. Project ID CSS 033. Huntingdon Life Sciences|Ltd., Cambridgeshire, England.
Hunter JV (1973). Effect of dyes on aerobic systems. Chapter|VII in: Dyes and the environment, Vol. I, American Dye|Manufacturers Institute Inc.
BASF AG, Hauptprufung fur Journal Nr 09950, prufung auf okotoxizitat: Hemmung der Algen-Zellvermehrung nach DIN 38412 L 9, butylglycolacetat, dated 18.09.1989. [Main test for study for ecotoxicity; algal cell reproduction inhibition according to DIN 38412 L 9, butylglycolacetate
Method: other: Galloway et al (1985, 1987)
BUA (1991). Chemical Reports No. 81 (short reports), August|1991: Formic acid, formates. Edited by Beratergremium für|umweltrelevante Altstoffe (BUA) der Gesellschaft Deutscher|Chemiker. VCH Publishers, Weinheim, Germany.
Hatch, G.G., Mamay, P.D., Ayer, M.L., Casto, B.C., Nesnow,|S., 1983. Chemical enhancement of viral transormation in|Syrian hamster embryo cells by gaseous and volatile|chlorinated methanes and ethanes. Cancer Res. 43:1945-50.
Method: other: transformation by AS/adenovirus in sealed chambers
IRDC (Int. Research & Development Corp): unpubl. report No.|5701-1-303, July 13, 1983b (Short communication)
BGIA (Berufsgenossenschaftliches Institut fuer Arbeitsschutz) (2005). GESTIS-database on hazardous substances. www.hvbg.de/bgia/gestis-database.
Melting point/freezing point, IUC4#92/Ch.2.1
Method: other (calculated): SRC Kowwin v1.67 Computer Program, integrated in U.S. EPA's EPI program Vers. 3.11
Meier, J.R., Bull, R.J., Stober, J.A. and Cimino, M.C.|(1985): Evaluation of chemicals used for drinking water|disinfection for production of chromosomal damage and|sperm-head abnormalities in mice. Environ Mutagen, 7,|201-211.
Short-term toxicity to fish, IUC4#42/Ch.4.1
Horton, J.R. et al.: Interim Tech. Report AFAMRL-TR81-131,|Contract F33615-80-C-0512, NTIS-AD-A110633-5, U.S. Air|ForceAerospace Medical Research Laboratory, Wright Patterson|Air Force Base, Dayton, Ohio (1981), No information
RTECS TK8050000 Marhold J.: Prehled Prumyslove Toxicologie; Organicke Latky; 1986 (prague), p 864. (Eng/Fr/Ger/Dutch translation not available)
Knaap, A.G.A.C. & Langebroek, P.B., Prog. Mutat. Res. 5,|531-536 (1985)
BASF AG, Labor Oekologie; unveroeffentlichte Unter-suchung, (Original registration No. 1901210, Date: 23.10.1990)
Chinese hamster primary liver (CH1-L) cells
tetrasodium 4,4'-bis[[4-[bis(2-hydroxyethyl)amino]-6-(4-sulphonatoanilino)-1,3,5-triaz in-2-yl]amino]stilbene-2,2'-disulphonate] (IUC4 DSN 41)
Repeated dose toxicity: oral, IUC4#37/Ch.5.4
Takemoto K, Yoshimura H, Matsushita S (1978) Experiment of|pulmonary tumorgenicity of benzotrichloride. Proceedings of|the 51st Annual Meeting of the Japan Assoc Ind Health: 514 -|515
Morel C, Gendre M, Cavigneaux A and Protois JC (1982). Fiche toxicologique No 166: diisocyanate d'isophorone. Cah. Notes Doc. 106, 151-154.
Ambrose, D. J.H. Ellender, H.A. Grundy, D.A. Lee, and R. Townsend. 1981. Thermodynamic Properties of Organic Oxygen Compounds. LI. The Vapor Pressures of Some Esters and Fatty Acids. J. Chem. Therm. 13: 795-802
Matsui S, Okawa Y, and Ota R (1988). Experience of 16 yearsoperation and maintenance of the Fukashiba industrial|wastewater treatment plant of the Kashima petrochemical|complex - II. Biodegradability of 37 organic substances and|28 process wastewaters. Wat. Sci. Tech. 20(10), 201-210.
Method: other: respiration meter method ("BOD tester")
Biodegradation in water: screening tests, IUC4#27/Ch.3.5
Method: other: according to Skopek et al., Proc. Natl. Acad. Sci. 75, 410-414, 1978
E.I. DuPont De Nemours, Inc. (2004). DuPont isophorone|diamine exposure questionnaire (unpublished).
Dow Chem Co (1944) The toxicity of p-Nitrochlorobenzene - A|Review. 05. Aug. 1944: EPA-OTS0557232
BASF AG, Physikalisch-chemische Konstanten,|unveröffentlichte Untersuchung, Bericht BRU 88.108,|21.06.1988
Method: other (measured): dynamic with argon
De Flora S., Camoirano A., Zanacchi P.,Bennicelli C. (1984),|Mutagenicity testing with TA97 and TA 102 of 30 DNA-damaging|compounds, negative with other Salmonella strains: Mutat.|Res. 134, 159-165
Yoder, R. 2003. Electrospray ionization mass spectrometric study of dioctyltin compounds in solution. Internal industry report. ATOFINA Chemicals, Inc. May 1, 2003.
Mirsalis JC, Hamm TE Jr, Byron E, Butterworth B (1981). The|role of gut flora in the induction of DNA repair in rats|treated in vivo with dinitrotoluene. Proc Am Assoc Cancer|Res 22, 78.
Method: other: according to Mirsalis J.C. et al., Carcinogenesis 1, 621-625 (1980)
Micronucleus test in Chinese hamster lung cell line (CHL/IU)
Kirk-Othmer (1992). Encyclopedia of Chemical Technology. 4th|edition, Volume 2, John Wiley & Sons Inc., New York, 3.
Barassin and Combourieu.: Bull. Soc. Chim. 1974:1-5|(1974).
Phototransformation in air, IUC4#13/Ch.3.1.1
Casto, B.C, Meyers, J. and DiPaolo, J.A. (1979) Enhancement|of viral transformation for evaluation of the carcinogenic|or mutagenic potential of inorganic metal salts. Cancer|Res., 39, 193-198.
Itakura, C. (1975) Experimental investigations on effects of|chemical spreading to prevent roadway accidents caused by|formation of ice on paved road surface in winter and|influence of the chemicals to growing of several trees.|Proc. Hokkaido Inst. Technol., 3(7), 1-25. (in Japanese)
Scott G.I. and al; 1980 . Physiological effects of|chlorine-produced oxidants, Jolley R.J. and al., EDS, Water|chlorination Ann Arbor Sci.Publ., Ann Arbor, MI ; 501-516
Long-term toxicity to aquatic invertebrates, IUC4#5/Ch.4.5.2
Maas-Diepeveen JL, van Leeuwen CJ (1986) Aquatic Toxicity of|Aromatic Nitro Compounds and Anilines to Several Freshwater|Species. Laboratory for Ecotoxicology, Institute for Inland|Water Management and Waste Water Treatment, Report No.|86-42: 10 p.
Method: other: according to the method described by Könemann (1981)
BIBRA Toxicity profile (1987). Glycerol. (Hannuksela, 1979).
Carpenter, C.P. and Smyth, H.F.: J. Ophthalmol. 29,|1363-1372 (1946);|cited in: IPCS Environ. Health Crit. 89, (1989), No information
Genetic toxicity in vitro, IUC4#232/Ch.5.5
Gulati DK, Witt K, Anderson B, Zeiger E and Shelby MD|(1989). Chromosome aberration and sister chromatid exchange|tests in Chinese hamster ovary cells in vitro III: results|with 27 chemicals. Environ. Molec. Mutagen. 13, 133-193.
Mumford SA, Phillips JWC (1950). The Physical Properties of|Some Aliphatic Compounds. J.Chem.Soc. 75-84.
Bradley PM, Chapelle FH, Landmeyer JE, Schumacher JG (1997).|Potential for intrinsic bioremediation of a DNT-contaminated|aquifer. Ground Water 35 (1), 12-17.
Method: other: Method similar to OECD guideline 410
Repeated dose toxicity: dermal, IUC4#15/Ch.5.4
Hoechst AG (1986): Unpublished study. beta-Naphthol D.|Prüfung auf Augenreizung am Kaninchen (in German). Report|number 86.0917, 20 Aug 1986
Infracor Degussa Group (1993) Final Report DL 170:|Determination of the growth of DYNASYLAN GLYMO on the|reproduction rate of Daphnia magna (as specified by OECD|Guideline 202 Part II) (English translation of the German|Final Report dated 28.07.1997). Degussa AG-Nr.:|97-0273-DGO.
Method: other: according to Draize et al., J.Pharmacol.Exper.Therap.82, 377 (1944)
Hoechst AG (1986): Unpublished study. beta-Naphthol D.|Prüfung auf Hautreizung am Kaninchen (in German). Report no.|86.0876, 15 Aug 1986.
Nieboer, E., Bryant, D.W., and Verma, D.K., Toxicological|Profile for Di-N-propylamine, Diisopropylamine, Piperidine,|Triethylamine, and Triethylenediamine, special report|(DREO), McMaster University, 19 Nov 1992
Environmental Mutagens Data Book, pp. 88-89
Genetic toxicity in vitro, IUC4#101/Ch.5.5
Kreja, L. and H.-J. Seidel (2002) "Evaluation of the genotoxic potential of some microbial volatile organic compounds (MVOC) with the comet assay, the micronucleus assay, and the HPRT-gene mutation assay." Mutation Research Vol. 513, pp.143-150.
Hoffmann LaRoche Inc., data compilation, ecotoxicological|evaluation, beta-ionone, unpublished data, E-29/89, 02 Aug.|1989
Applegate et al. (1957): Spec. Sci. Rep.-Fish. No. 207, Fish|Wildl. Serv., U.S. D.I., Washington, D.C.: 157
Method: other: Laboratory statistic methode
Short-term toxicity to fish, IUC4#25/Ch.4.1
Saladino, A.J. et al.: Cancer Res. 45, 2522- 2526 (1985), No information
Genetic toxicity in vitro, IUC4#216/Ch.5.5
Hansch,C., Leo,A.J., Substituent Constants for Correlation|Analysis in Chemistry and Biology; Claremont, CA: Pomona|College (1979)
RTECS, update 9301 (through July 1993): Toxicol. Appl.|Pharmcol. 2, 23 (1960)
Hansch, C., Leo, A., D. Hoekman. Exploring QSAR -|Hydrophobic, Electronic, and Steric Constants. Washington,|DC: American Chemical Society., 1995., p. 14. cited in HSDB|21 Sep 2006
Palomaa MH, Mikkilä I (1942). Studien über ätherartige|Verbindungen, XXVII. Mitteil.*): Trübe Phase bei|Verbindungen mit Reaktionsminimum. Chemische Berichte 75,|1659-1667.
Zeiss CR, Leach CL, Levitz D, Hatoum NS, Garvin PJ,|Patterson R, 1989. Lung Injury Induced by Short-Term|Intermittent Trimellitic Anhydride (TMA) Inhalation. J|Allergy Clin Immunol. 84(2):219-223.
Dodard SG, Renoux AY, Hawari J, Ampleman G, Thiboutot S,|Sunahara GI (1999). Ecotoxicity characterization of|dinitrotoluenes and some of their reduced metabolites.|Chemosphere 38, 2071-2079.
Method: other: 96-well microplate method
Method: other (calculated): Estimated using MPBPWIN (ver 1.40)
Bayer AG, Internal Study: GLP Final Report: vapor pressure,|physical-chemical properties (2001-07-12)
Leung MF, Geoghegan-Barek K, Zamansky GB, Chou IN (1990)|Microtubule disassembly induced by sensitizing halogenated|nitrobenzene derivatives. Toxicol in Vitro 4: 252 - 263
Herbold B.A., 1993; o-nitroaniline Micronucleus test on the|mouse - Study T 1050079 - Bayer AG Report No. 22381, July|1993
Morita T, Iwamoto Y, Shimizu T, Masuzawa T, Yanaghara Y|(1989) Mutagenicity tests with a permeable mutant of yeast|on carcinogens showing flase-negative in Salmonella assay.|Chem Pharm Bull 37: 407-409
Chemicals Evaluation and Research Institute (CERI).|Bioaccumulation study of octadecyl|3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate. (1996).|Report number: 51207.
Dow Chemical Company Material Safety Data Sheet for|diethylene glycol monohexyl ether.
Celanese Chemicals Company (2001). Safety Data Sheet, Formic|acid 95 %, status 04 Jan 2001.
Haidour A and Ramos JL (1996). Identification of products|resulting from the biological reduction of|2,4,6-trinitrotoluene, 2,4-dinitrotoluene and|2,6-dinitrotoluene by Pseudomonas sp. Environ. Sci. Technol.|30 (7), 2365-2370.
Hoechst AG. 1988. Unveroeffentlichte Untersuchung [unpublished study](88.0353)
Tokai A, Nakanishi J (2001) Chemical Risk Assessment based|on the Framework of Basin-Wide Ecological Modeling and the|Ecotoxicological Index. In: Linkov I, Palma-Oliveira J (eds)|Assessment and Management of Environmental Risks, Kluwer,|pp. 173 - 186
Ciba-Geigy Ltd., TK 10044, 3-month toxicity study on dogs,|Project No. 790857, 14.9.1981.
Method: other: mainly according to OECD 409
Hayatsu H, Miura A (1970) The mutagenic action of sodium|bisulfite. Biochem Biophys Res Comm 39: 156-160
Method: other (calculated): Estimated - AOPWIN
Gervasi P, Citti L, Del Monte M, Longo V and Benetti D|(1985). Mutagenicity and chemical reactivity of epoxidic|intermediates of the isoprene metabolism and other|structurally related compounds, Mutat. Res., Vol. 156, pp.|77-82.
Zeiger et al. (1988) Environmental and Molecular Mutagenesis. Volume 11:1-158.
Degussa-Huls AG (1995) Determination of bacterium toxicity|of DYNASIL A In Oxygen Consumption Test (Huls method). Final|Report. PZ-95/15. Degussa-Huls AG-Nr. 95 0225. DGO. 9/15/95
Bayer AG (1988). Internal report No.88120126: Fish toxicity,|bacteria toxicity and biodegradation of C.I. Fluorescent|Brightener 28/113 (98 % free acid), 1988-03-25.
Method: other: comparable to OECD Guide-line 203
Union Carbide Corporation, Solvents & Coatings Materials|Division. Material Safety Data Sheet: C0296F, Dated 10/18/95
Ciba Safety Data Sheet according to Directive 91/155/EEC|Irganox 1076, 06.02.2003.
Exxon Chemical Americas / Hazelton Labs. Inc. (1968).|Assessment and comparison of subacute inhalation toxicities|of three ketones. NTIS/OTS Microfiche 0206267, Doc|878210935.
Method: other: Inhibition of photoluminescence
Schleiermacher, E. et al.: Dtsch. Med. Wochenschrift 92,|2343-2350 (1967)
Behrens,U., Hannes,U., Acta hydrochim. hydrobiol. 12(1), |39-45, 1984, No information
Purchase et al. (1978) Br. J. Cancer 37:873-903.
Mohsen M (1979) Effect of Polar Substituents on Autooxidiation of Phenol, Water Research 13:1125-1128.
Alizade S.M. et al, 1982, Azerb. Med. Zurnal, V59, NR2,|P.66-70.
Klimm, W., Janz, S., Gabert, A. (1989): Experimentelle|Untersuchung zur Genotoxizitat verschidener|Wurzelkanalantiseptika im SOS-Chromotest. Zahn- Mund-|Kieferheilkd, 77, 128-130.
Walterson, E., O. Sangors, and L. Landner. 1993. The Swedish National Chemicals Inspectorate. Swedish Environmental Research Group (MFG). Environmental Hazard Assessment of Mono- and Di-substituted Organotins. KEMI Report No. 11/94.
Adsorption / desorption, IUC4#9/Ch.3.3.2
BIBRA (1998) A 28-day study in rats with thioglycolic acid, 2-ethylhexyl ester including investigations of hepatic peroxisomal activity. Report # 689/1/88.
Riach CG (1994). 4,4'-Dichlorodiphenyl Sulphone Mouse Lymphoma Mutation Assay. Inveresk Research International, Report No. 10781.
Klimisch, H.-J. 1990. Prenatal Toxicity of 2-Methyl-1-Propanol in Rats After Inhalation. Project No. 37R0057/88047. BASF Department of Toxicology, BASF Corp. 6700 Ludwigshafen, West Germany.
BASF AG, Sicherheitsdatenblatt [safety data sheet] Butyldiglykolacetat (11/87)
Goldman, A.S. and Yakovac, W.C.: Arch. Environ. Health. 8,|648-656 (1964), cited in: WHO International Programme on|Chemical Safety (IPCS): Environmental Health Criteria 54:|Ammonia, 131 (1986)
Vasilenko, N.M. and Zvezdai, V.I.: Gigiena Truda i|professionalnye Zabolevaniia 8, 60-63 (1974)
SPARC On-line calculator, University of Georgia, USA.|http://ibmlc2.chem.uga.edu/sparc/
Muse, W.T., Anthony, J.S., Thomson, S.A.: Acute inhalation|toxicity of chemically neutralized HD in rats. Edgewood|chemical biological center, Report No. ECBC-TR-067 (2000)
Method: other: US Department of Transportation guidelines desribed in CFR49, part 173.132-173.133 (10/1/94 edition)
Degussa AG, unpublished report, 1992 4-Week oral toxicity in rats incl. Recovery period. Degussa Report No. 92-0151-DGT
Bushy Run Research Center (BRRC) (1991). A-187 Hydrolysate|Four-Week Aerosol Inhalation Study in|Rats: Assessment of the Potential to Produce Laryngeal|Granulomas; Bushy Run Research Center (BRRC); BRRC Project|Report 54-34, August 20, 1991.
Shelby MD, Erexson GL, Hook GJ and Tice RR (1993) Evaluation|of a three-exposure mouse bone marrow micronucleus protocol:|results with 49 chemicals. Environ Mol Mutagen, 21, 160-179.
Method: other: equivalent to OECD Guide-line 474
Stephen H and Stephen T (eds., 1963). Solubilities of|inorganic and organic compounds, Volume 1, Binary Systems|Part 1, Pergamon Press, London, p. 138.
Boethling RS, Howard PH, Stiteler W, and Hueber A (1997).|Does the semi-continuous activated sludge (SCAS) test|predict removal in secondary treatment? Chemosphere 35(10),|2119-2130.
Repeated dose toxicity: inhalation, IUC4#56/Ch.5.4
Burgess, D. und Wirth, J.N., Acute Toxicity of Tributyl |Phosphate to Selenastrum capricornutum Printz. June 21,|1990, ABC Laboratories No. 38554, Columbia, Missouri, USA
Method: other: static (ABC Protocol 8004-PMN)
Method: other: OECD Proposal (1979: Report on the assessment of Potential Environmental Effects of Chemicals I)
Zabrejko S, Goncharova RI (1989) Clastogenic activity of|some phthalates (ph) in in vivo somatic mouse cells. Mutat|Res 216, 283-284
Merck Index, 1996, 12th edition, New York, USA, p 1452.
Allied Corporation. Genetic Toxicology Studies of|[3-Glycidoxypropyltrimethoxysilane] (Allied Corporation|Report No. MA-168-81-12).
Lide DR (2000) CRC Handbook of Chemistry and Physics 82nd|ed. CRC Press Inc., Boca Raton, Florida, page 3-56
Aeschbacher, H.U. et al.: Mutat. Res. 57, 193-200 (1978)
Genetic toxicity in vivo, IUC4#53/Ch.5.6
Costes C (1966): Biosynthèse du phytol des chlorophylles et|du squelett tétraterpénique des caroténoïdes dans les|feuilles vertes. Phytochem 5: 311-324.
BASF AG (1980). Bericht über die Prüfung der akuten|Inhalationsgefahr (akutes Inhalationsrisiko) von|"Ameisensäure p.a. (98%) MERCK als 50%ige Lösung in Wasser"|an Sprague-Dawley Ratten. Unpublished study report on|substance No. 79/422, dated January 10, 1980.
Degussa AG: The acute toxicity with ULTRASIL VN 3 and|Daphnia magna (OECD guideline 202, 24 h). Unpublished|report: Degussa AG - US-IT-No. 92-0162-DGO, TNO, 1992d
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K|(1992) Salmonella Mutagenicity tests: V. Results from the|testing of 311 chemicals. Environm Mol Mutagen 19, Suppl 21:|2-141
Method: other: preicubation protocol according to Haworth, 1983 Environ. Mutagen.5 [Suppl 1], 3-142, see freetext ME
Spanggord RJ, Mortelmans, KE, Griffin AF, Simmon VF (1982)|Mutagenicity in Salmonella typhimurium and|structure-activity relationships of wastewater components|emanating from the manufacture of trinitrotouene. Environ|Mutagen 4: 163-179
Method: other: plate incorporation assay according to de Serres and Shelby, Environ. Mutagen. 1, 87 (1979)
Cohen Y., Pe'er S., Balass O. and Coffey M.D., 1987, A|fluorescent technique for studying growth of Peronospora|tabacina on leaf surfaces, Phytopathology 77, 201-204
Method: other: determination of MIC in Petri dishes
Pardee, W.A. et al., Industrial and Engineering Chemistry|36(7), 595 - 603 (1944)
Ling, Xiong, Qian (1986): Huanjing Huaxue 5(4), 7-13; cited|in: Chem. Abstr. 106, 37903e (1987)
Biodegradation in water: screening tests, IUC4#48/Ch.3.5
Grafstrom, R.C. et al.: Science 220, 216-218 (1983), No information
Genetic toxicity in vitro, IUC4#209/Ch.5.5
Macht, D. (1939), Comparative Pharmacology of Menthol and|its Isomers, Arch. Int. Pharmacodyn. 63, 43-58
CERI (2004). Biodegradation study of Tetrahydrofurfuryl|alcohol: CAS No. 97-99-4. Test Number 205037. Unpublished|data.
Kashima R. et al., Contact dermatitis 28, 235-242 (1993)
Method: other: additional animal studies are reported
Krul, C.A.M. 2002. Bacterial reverse mutation test wuth dibutyloxostannane. Report V4405/03. Department of Biomolecular Sciences, TNO Food and Nutrition Research, 3700 AJ Zeist, The Netherlands. 15 July 2002.
Huntingdon Research Centre Ltd. (1988) Twenty-eight day oral|toxicity study in rats with Isobutyltriethoxysilane|(IBTEO). Report DNN 16/88424. Degussa-Huls AG-Nr.:|88-0301-FKO August 12, 1988
RCC-NOTOX (1988a): Assessment of the acute toxicity of Benzoguan- amine on the cell multiplication of a pure culture of Pseudomonas putida bacteria, Laboratory Proj. Ident. 0913/PS17, May 1988
Method: other: cell multiplication inhibition test (turbidity test)
Peter, H., Laib, R.J., Ottenwilder, H., Topp, H., Rupprich,|N. and Bolt, H.M.: Arch. of Toxicol. 57:84-87 (1985).
Sokal J. et al.: Pol. J. Pharmacol. Pharm. 32, 223-229,|(1980)
Acute toxicity: dermal, IUC4#26/Ch.5.1.3
RTECS (2001) Registry of toxic effects of chemical|substances, data base CAS 67-48-1. Jan. 2001
Method: other: dynamic under nitrogen atmosphere
Method: other (calculation): with PCKOCWIN v.1.66, 2000
Takasaki, Y. et al, Iyakuhin Kenkyu, 21(2), 257-264 (1990)
BASF AG, Technical Information 'Products for the Feed|Industry', Edition 2003
Bringmann G and Kuehn R (1977). Befunde der Schadwirkung|wassergefaehrdender Stoffe gegen Daphnia magna. Z. Wasser-|Abwasser Forsch. 10 (5), 161-166.
Method: other: immobilization test according to Bringmann G and Kuehn R
Repeated dose toxicity: inhalation, IUC4#92/Ch.5.4
Dow Chemical Company (2005). Toxicology & Environmental|Research and Consulting, laboratory project study ID 041118,|unpublished report.
Dellarco V.L., Prival M.J. (1989): Mutagenicity of nitro|compounds in Salmonella typhimurium in the presence of|flavin mononucleotide in a preincubation test. Enviro. Mol.|Mutagen. 13(2), 116-127
Method: other: According to Ames, with 30 mn preincubation without shakingand use of FMN(flavin mononucleotide) cofatctor
Method: T31-18:Chemical Substances Control Law of Japan and OECD Test Guideline 471
Acute toxicity: inhalation, IUC4#19/Ch.5.1.2
Sporgis, L. (1961) Latv. PSR Zinat. Akad. Vestis (Bulletin|of the Academy of Sciences of the Latvian SSR) 1:71.
Biodegradation and Bioaccumulation Data of Existing|Chemicals Based on the CSCL Japan, edited by Chemicals|Inspection & Testing Institute Japan, published by Japan|Chemical Industry Ecology-Toxicology & Information Center,|October 1992
Adema D.M.M. and G.H. van den Bos Bakker (1987) Aquatic|toxicity of compounds that may be carried by ships (Marpol|1973, Annex II). A progress report for 1986. Report |n. R 86/326a. TNO Netherlands:1-20.
Steinhaeuser KG, Ammann W and Polenz A (1986).|Biodegradability testing of chloroorganic compounds. Vom|Wasser 67, 147-154.
Skin irritation / corrosion, IUC4#50/Ch.5.2.1
BASF AG, Department of Toxicology, unpublished results,|(XIII 27), 17 Feb. 1964
GAF (1979). Aquatic Toxicology Laboratory, contract|No. L1393-05, May 1979 (unpublished).
Ciba-Geigy Ltd., Report on the growth inhibition test of|Irganox 1076 to Green Algae (Scenedesmus subspicatus),|Project No. 928140, 12.11.1992.
Laboratory of Pharmacology and Toxicology (1994). Acute|toxicity study of tungsten carbide (WC) by oral|administration to Sprague-Dawley rats -Limit Test- according|to EC guideline B.1. and OECD method 401-. Unpublished LPT|Report No. 8893/94, November 18, 1994.
CIBA-GEIGY, Ltd. 1982. Report on Acute Aerosol Inhalation Toxicity in the Rat of TK-10422. GU Project No.: 81-1811. 26.02.1982.
Method: other: Sachsse et al. (1973, 1976)
Mackison, F.W., R.S. Stricoff, and L.J. Partridge, Jr. (eds.). 1981. NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards (3 Volumes). DHHS (NIOSH). Publication No. 81-123. U.S. Government Printing Office. Washington, DC.
Type of cell used: Chinese hamster lung(CHL/IU) cell
Method: other: Acute Toxicity test for Daphnia according to DIN 38412/11
Kieckebusch, W. & Lang, K., Arzneim.-Forsch. 10, 1001-1003|(1960)
Snell T.W. and al., Acute toxicity tests using rotifers IV .|Effects of cyst age, temperature and salinity on the|sensitivity of Brachionus calyciflorus Environ.Safety 21(3),|308-317
Hamaguchi F. and Tsutsui T. (2000). Assessment of|genotoxicity of dental antiseptics: ability of phenol,|guaiacol, p-phenolsulfonic acid, sodium hypochlorite,|p-chlorophenol, m-cresol or formaldehyde to induce|unscheduled DNA sythesis in cultured syrian hamsetr embryo|cells. Japan.J.Pharmacol. 83, 273-276., No information
Genetic toxicity in vitro, IUC4#234/Ch.5.5
Liu J, Lang P (1995) Toxicities of Nitroaromatic Compounds|to Scenedesmus obliquus and Toxic Symptoms. Huanjing Kexue|16: 7 - 10
Phototransformation in air, IUC4#8/Ch.3.1.1
de Jong, L.E.D.D. (1965) Tolerance of Chlorella vulgaris for|metallic and non-metallic ions. Antonie van Leeuwenhoek (J.|Microbiol. Serol.), 31, 301-313.
Huntingdon Research Center Ltd.(1989b),Microbial Metabolic|Activation test to Assess the potential mutagenic effect of|Solfit. Unpublished report
Monsanto (1978) Aquatic Toxicity Studies with Santoflex 13.|Unpublished study No. AB-78-121A
Lonza AG, unpublished report, 1977, Acute oral LD50 Toxicity, Bio-Toxicology Laboratories Inc., Lonza Report No. 234
Method: other (calculated): Estimated value with MPBPWIN v.1.41
Genetic toxicity in vitro, IUC4#186/Ch.5.5
Busch RH, McDonald KE, Briant JK, Morris JE, Graham TM|(1983). Pathologic effects in rodents exposed to sodium|combustion products. Environmental Research, 31, 138-147.
Guseinov, V.G. (1983) Toxicological characteristics of allyl chloride. Toksicol. Gig. Klin. i Prof. Vozdeistviya, Klorist.Allila na Organizm Rabotayushchikh v, 6-37
Dow Corning Corporation (2002). Report No. 9610. Prepared|for the Silicone Environmental, Health and Safety Council.
Salmonella typhimrium TA98, TA100, TA1535, TA1537, TA1538
Bayer AG, Safety data sheet p-Nitrochlorobenzene pure|(2001.11.06)
Cultured primary human diploid foreskin cells
Beilstein (2003) Beilstein online databank, Beilstein|Registry Number 221591
McGregor, D.B., 1981. Tier II mutagenic screening of 13|NIOSH priority compounds, Report No. 32 - Individual|compound report: methyl bromide. Cincinnati, Ohio, National|Institute of Occupational Safety and Health, 190 pp|(PB83-130211).
Suovaniemi O, Ekholm P, Falck K, Kaukanen E, Kinnunen R,|Partanen P, Sorsa M, Vainio H (1985) An automated analysis|system for bacterial mutagenicity assays. Am Lab: 122-129
Method: other: Mutascreen automated system for bacterial mutagenicity tests
Genetic toxicity in vitro, IUC4#49/Ch.5.5
Emmrich M (2001). Kinetics of the alkaline hydrolysis of|important nitroaromatic co-contaminants of|2,4,6-trinitrotoluene in highly contaminated soils. Environ.|Sci. Technol. 35, 874-877.
Lindahl-Kiessling K, Karlberg I, Olofsson AM (1989)|Induction of sister-chromatid exchanges by direct and|indirect mutagens in human lymohocytes, co-cultured with|intact rat liver cells. Mut Res 211: 77-87
Method: other: Krishna, G.J.N. and Oug, T. (1986): Teratogen. Carcinogen. Mutagen. 6, 321-330
Genetic toxicity in vitro, IUC4#123/Ch.5.5
Method: other: anaerobic degradation, static, 35 degree C, parameter:gasproduction
Salmonella typhimurium TA98, TA100 and TA104
Based on a measured log Pow of 8.8, a bioconcentration|factor for isophytol was estimated by BASF Co. at 2,870,781|based on a regression equation (log BCF = 0.76 * logPow -|0.23) published in Lyman W.J.; Reehl W.F.; Rosenblatt D.H.:|Handbook of Chemical Property Estimation Methods. American|Chemical Society Washington, DC (1990).
Marhold, J. V. (1972 in Czech), cited in RTECS (1999) NIOSH,|USA
BASF AG, Labor fuer Umweltanalytik; unpublished results (1/89)
Ruzicka L, Kobelt M, Haefliger O and Prelog V (1949).|Vielgliedrige heterocyclische Verbindungen 12,|Polymethylenimine. Helv. Chim. Acta 32, 544-552
Kao, F.T. and Puck, T.T.: J. Cell Physiol. 74, 245-258|(1969);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Yamagami, T. et al.: Surg. Neurol. 20, 323-331 (1983);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Method: other (calculation): no data given
Melting point/freezing point, IUC4#70/Ch.2.1
Method: other: Die-Away-Test acc. to Brit. Standing Technical Committee, 1967
Varilyak I., Kozachuk S., On mutagenic reaction of various|spirits under experiment, Tsitol. Genet, 19:436-442, 1985
Dura G, Krasovski GN, Zholdakova ZI, Mayer G (1985)|Prediction of Toxicity Using Quantitative Structure-Activity|Relationships. Arch Toxicol Suppl 8: 481 - 487
L5178Y TK+/- mouse lymphoma cell clone 3.7.2C
Acedo GN, Redei GP (1982) Accuracy of the identification of|carcinogens and noncarcinogens by arabidopsis. Arabidopsis|Inf Serv 19: 103-107
Genetic toxicity in vitro, IUC4#128/Ch.5.5
Litton Bionetics (1974). Mutagenic evaluation, final report on compound H-9070. Report No. 834-74, at the request of Haskell Laboratory/DuPont Co., November 11, 1974 (NTIS OTS 539545).
Hoechst AG (1987) Material Safety Data Sheet|Nitro-o-dichlorbenzol asymetrisch (1987-09-23)
growth inhibition (based on area under growth curve), cell counts
Belly R.T. and Goodhue C.T. Proceedings of the|International Biodegradation Symposium. 3:1103-1107 (1976)
EpiSuite (2007) v3.12. Developed by the EPA's Office of Pollution Prevention and Toxics and Syracuse Research Corporation (SRC). Copyrighted.
Method: other: WATERNT Program (v1.01) fragment analysis
BASF AG, Abteilung Toxikologie, unveroeffentlichte|Untersuchung, (XIX/401=XIX/477), 17.08.1970
Bayer AG data, Report No. 20209(F): Enzymhistochemisch|darstellbare Veränderungen des Kohlenhydratstoffwechsels der|Mausleber nach Gabe von o-Chlornitrobenzol, May/6/1991
Method: other: according to OECD Guideline 407, 1981; 12 mice/sex/group and additional 6 mice/sex/group for the interim sacrifice
Geiger, D. L. et al, Acute Toxicity of Organic Chemicals to Pathead Winnows (Pimephales promelas) Vol. IV, EPA, US, Center for Lake Superior Environmental Studies, Superior, WI. ISBN 0-9614968-3-5 (1988)
Bishun et al. (1973) Chem-Biol Interactions, 6, 375-392
exp. design 1) E. coli K12 and exp. design 2) E. coli B
Long RM, Rickert DE (1983) Hepatic Marcromolecular covalent|binding and intestinal disposition of mononitrotoluenes. |The Toxicologist 3: 323
Moolenaar, R.J. (1981): Environmental Impact Statements,|Environmental Properties of Chlorine. unpublished report of|The Dow Chemical Company.
Carney EW, Zablotny CL, Andrus AK, Marable BR and Thomas J.|2004. Diethylene glycol hexyl ether: A combined dietary|toxicity study with the reproduction/developmental toxicity|screening test in CD rats. Toxicology & Environmental|Research and Consulting, The Dow Chemical Company. Study|dated February 17, 2004.
Method: other: combined dietary toxicity study with the reproductive/developmental toxicity screening test in CD rats (OECD 422)
Flaningam, O.L. 1979. Dow Corning Corporation, Report No.|1979-I0039-11.
BASF AG, Department of Toxicology, unpublished results,|N-Methylpyrrolidone: Synopsis of Proj. Nos. 36I0587/89023,|/89042, /89044, /89045, /89054, /89069, /89070 and|supplement report (Techn. Part), 19 May 1995b
Mochizuki, M. (1995). A 4-week oral toxicity study of sodium|gluconate (FR2531). Final report No. BOZO/B-2966 from|Gotemba Laboratory, Bozo Research Center, Inc., Setagaya-Ku,|Tokyo 156, Japan.
Bruce LJ, Daugulis AJ (1991): Solvent selection strategies|for extractive biocatalysis. Biotechnol Prog 7(2): 116-124.
Malley LA, Kennedy GL, Elliott GS, Slone TW, Mellert W,|Deckardt K, Gembardt C, Hildebrand B, Parod RJ, McCarthy TJ, Griffiths JC (1999) 90-Tag subchronic toxicity studies in rats and mice fed N-Methylpyrrolidone (NMP) including|neurotoxicity evaluation in rats. Drug Chem Toxicol, 22,|455-480
Method: other: OECD Guide-line 408, US EPA TSCA, Test guideline 40 CFR 798.2450, US EPA Neurotoxicity Subdivision F
Geiger DL, Brooke LT, Call DJ (1990) Acute Toxicities of|Organic Chemicals to Fathead Minnows (Pimephales Promelas),|vol.5. Center for Lake Superior Environmental Studies,|University of Wisconsin, Superior, WI, 332
Kaiser KLE, Ribo JM (1985) QSAR of Toxicity of Chlorinated|Aromatic Compounds. Pharmacochem Libr 8 (QSAR Toxicol|Xenobiochem): 27 - 38
Toxicity to microorganisms, IUC4#200/Ch.4.4
Bridie AL, Wolff CJM, Wint M (1979) The Acute Toxicity of|Some Petrochemicals to Goldfish, Water Research 13, 623-626
Method: other: APHA for static tank acute toxicity tests
Hommel G (1991). Handbuch der gefährlichen Güter, Merkblatt 917. 2. neubearbeitete Auflage. Springer Verlag (Berlin).
Method: other: (calculated) BCFWIN v2.17
Demerec M, Bertani G, and Flint J (1951). A survey of|chemicals for mutagenic action on E. coli. The American|Naturalist 85, 119-136.
National Institute of Environmental Research(NIER), Korea(2001), Test of Acetanilide melting point/melting range(tested by LGCI )
Dunn, B.J. (1978) Primary Dermal Irritation Test, Toluene diamine,|Allied Chemical Corporation, Project No.MA-12-77-02,|14.9.1978.
CIBA-GEIGY (1979). Internal report FAT 65'019/F: Biologische|Elimination / Akute Fischtoxizitaet /|Bakt.-Schlammtoxizitaet of C.I. Fluorescent Brightener|28/113 (22 % Na-salt), 1979-04-04.
BOD5 Method: other: CIBA-GEIGY Internal Method A-15
Hardin, B. D. et al.: Teratog. Carcinog. Mutagen. 7, 29-48|(1987)
ETAD (2001). Turck PA. Two generation reproduction and|fertility study via oral gavage in rats. MPI Research|Laboratory Study Identification No. 795-006 dated|2001-08-24.
EPA OPPTS 870.3800 (Reproduction and Fertility Effects)
Matsui et al. (1975): Prog. Water Technol. 7, Nos. 3/4,|645-659
Hamm, T.E.J., Raynor, T.H., Raynor, T.H., Phelps, M.C.,|Auman, C.D., Adams, W.T., Proctor, J.E., and Wolkowsky-Tyl:|R. Fund. Appl. Tox. 5:568-577 (1985).
Method: other: in general conformance with OECD 416
Degussa AG, unpublished report, 1986, Guinea pig maximisation test .Degussa report No. 86-0086-DKT
Covance Laboratories (2002). Formi LHS. Combined chronic|toxicity and 104 week oral (dietary administration)|oncogenicity study in the rat. Unpublished final study|report No. 1516/30-D6154 dated December 2002. Sponsored by|Hydro Nutrition, Oslo.
Acute toxicity: inhalation, IUC4#28/Ch.5.1.2
Bayer AG (1995a). Isophorondiisocyanat - study on acute inhalation toxicity in rats according to OECD No. 403 (English translation from the German). NTIS/OTS Microfiche 0558208, Doc 86-960000068.
Method: other: Directive 92/69/EEC;93/21/EEC, B.2 and OECD Test Guideline 403 (1981)
BASF AG, Labor Oekologie; unveroeffentlichte Unter-|suchung (1992)
Schering AG. 1990. ZK 26.385 Local Dermal Tolerance Test in Rabbits after a Single Application. Bericht Nr.: IC 31/89. 06.02.1990.
Brat, S.V. et al.: Mutat. Res. 63, 325-335 (1979);|cited in: RIFM database, location no. 11101
Cater et al., (1977). "Studies on Dibutyl Phthalate-Induced|Testicular Atrophy in the Rat: Effect on Zinc Metabolism".|Tox. And Applied Pharm., 41:609-618.
Toxicity to reproduction, IUC4#20/Ch.5.8.1
Method: other: Draize test, see also freetext ME
Dunnick J.K., Melnick R.L. (1993): Assessment of the|carcinogenic potential of chlorinated water: Experinemntal|Studies of chlorine, chloramine and trihalomethanes. J. Nat.|Cancer Inst. (85), 817 ff.
Method: other: generally followed OECD 453 Combined Chronic Tox/Carcinogenicity Study.
Orme et al. (1985). Effects of chlorine dioxide on thyroid|function in neonatal rats. J.Toxicol.Environ.Health, 15|p315-322.
Florin I, Rutberg L, Curvall M, Enzell CR (1980) Screening|of tobacco smoke constituents for mutagenicity using the|Ames test. Toxicol 8: 219-232
Helling CS (1971). Pesticide Mobility in Soils I.|Parameters of Thin-Layer Chromatography. Soil Sci. Soc.|Amer. Proc. 35, 732-737.
Method: other: soil-TLC method according to Helling 1971
Ullmann's Encyclopedia of Industrial Chemistry, Sixth|Edition, 2000 Electronic Release, 2000 Wiley-VCH Verlag|GmbH, Weinheim, Germany
Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B,|Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S, Rimpo J,|Margolin BH, Resnick BA, Anderson B, Zeiger E (1987)|Chromosome aberrations and sister chromatid exchanges in|chinese hamster ovary cells: evaluations of 108 chemicals.|Environ Mutagen 10 (Suppl 10): 1-175
Method: other: described in Galloway 1987, highest concentration was determined by solubility
Handbook of Chemistry and Physics (1970), R.C. Weast (Ed.)|51st edition, the Chemical Rubber Co., Cleveland, Ohio.|Cited in: Barratt MD (1995): Quantitative structure activity|relationships for skin corrosivity of organic acids, bases|and phenols. Toxicol Letters 75, 169-176
Thayer, P.S. and Kensler, C.J.: Toxicol. Appl. Pharmacol.|25, 157-168 (1973)
Genetic toxicity in vivo, IUC4#61/Ch.5.6
Yamada A, Morita S, Taniguchi S (1979) Acute oral toxicity|of sodium sulfite (anhydrous) in rats. Oosaka Shi Kanaken|Hokuku 42: 30 (In Japanese)
Bermudez, E. and Craft, T.R.: Environ. Mutagen. 9, 14|(1987); abstract no. 31, No information
Genetic toxicity in vitro, IUC4#221/Ch.5.5
Geiger D.L. et al.: Acute toxicity of organic chemicals to|fathead minnows (Pimephales promelas), Vol. IV, Center for|Lake Superior Environmental Studies, University of|Wisconsin-Superior, (1988)
Short-term toxicity to aquatic invertebrates, IUC4#35/Ch.4.2
Schering AG. 1991. ZK 22.663. Local Dermal Tolerance Test in Rats after a Single Application and a Subsequent Rinsing. Report No.: IC 1/91. 03.06.1991.
Randall DJ, Robinson EC (1990). Acute toxicologic evaluation|of phosphorus trichloride Monsanto Dept. of Med. and health|sciences|cited in: Acute Toxic. Data 1, 71-72. (J. Amer. Coll.|Toxicol. B,1 (1)).
Devillers J (1999) Autocorrelation Descriptors for Modeling|(Eco)Toxicological Endpoints. In: Devillers J, Balaban AT|(eds) Topological Indices and Related Descriptors in QSAR|and QSPR, Gordon and Breach Sci Publ, pp 595 - 612
Toxicity to microorganisms, IUC4#220/Ch.4.4
Karmazin V.E. et al (1969), Faktory Vnesh. Sredy Ikh. Znach.|Zdorov'ya Naseleniya, 1, 35-38.
Bayer AG (1990). Internal Investigation on the Acute|Toxicity for the Earthworm of Dinitrotoluene (80/20).|Unpublished Report (Report No. HBF/Rg 133)
Method: other: in accordance to OECD Guideline 207 "Earthworm, Acute Toxicity Test" (4. April 1984)
Christopher, S.M. November 30, 1993. "Isobutanol: Acute toxicity and irritancy testing using the rat (peroral and inhalation toxicity) and the rabbit (cutaneous and ocular tests)". Bushy Run Research Center, Union Carbide Corp. Lab. Proj. ID 92U1166
Sax NI and Lewis RJ (1987) in Hawley's Condensed Chemical Dictionary, 11th ed., 659. Van Nostrand Reinhold Co. (New York).
Nacalai Tesque MSDS No. 06835, Japan (Pub. 1993)
Smyth, H.F., Seaton, J., Fischer, L.: The single dose|toxicity of some glycols and derivatives. J. Ind. Hyg.|Toxicol. 23, 259-268 (1941)
United States Environmental Protection Agency. 2000. |Estimations Programs Interface (EPI) Suite™. The EPI Suite™|and the individual models included within the software are|owned and copyright protected by the U.S. Environmental|Protection Agency.
Sulzberger MB and Baer RL (1938) Sensitization to simple|chemicals. III. Relationship between chemical structure and|properties, and sensitizing capacities in the production of|eczematous sensitivity in man. J Invest Dermatol 1: 45 - 58
Method: other: according to Wedroff & Dolgoff (1935) Arch Dermat Syph 171, 647 - 664, see freetext TC
Biodegradation in water: screening tests.002
Reported in AIDA (13/11/92)-ALSTOFF INFORMATION Date Bank|from BASF AG, Ecological Laboratory-Unpublished Data|(1021/88).
Cattanach, B.M. in: Carlson and Gassner (eds.): Effects of|Ionizing Radiation on the Reproductive System, Pergamon|Press, Oxford, (1964); pp. 415-426;|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp., 291-390
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The Dictionary of Substances and their Effects, 2nd edition,|1999
Method: E09-04:ISO Guideline 8692 (ISO, 1993)
Smyth HF Jr, Seaton J, Fischer L. 1941. The single dose toxicity of some glycols and derivatives. J Ind Hyg Toxicol 23(6): 259-268.
QSAR.cerij.or.jp, physchem, biodegradation, bioaccumulation
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Gulf South Research Institute (1979) An Acute Test of|2-Butanone Peroxide (C55447) in B6C3F1 Mice and Fischer 344|Rats. Gulf South Research Institute, Atchafalaya Basin|Laboratories, New Iberia, Louisiana. Study #: Tracor Jitco|subcontract no. 78-61-106002; GSRI Project No. 415-927.|Study Date: July 23, 1979.
Huntingdon Life Science. Study no. 96-2483. MDP: 9-day|repeated exposure study by application to the skin of the|rat. Final report. Study conducted for Union Carbide|Corporation, USA, 09 Dec. 1999
Method: other: DIN 38412, Part 15 (Fish, short-time test)
Devillers J, Bintein S, Domine D (1996) Comparison of BCF|Models Based on log P. Chemosphere 33 (6): 1047 - 1065
BASF AG, 1989, Analytical Laboratory, Bestimmung des|Verteilungskoeffizienten Log Pow der Prüfsubstanz in|1-Octanol/Wasser bei 25°C, unpublished study, J.Nr.|106288/11, 02 May 1989
Method: other (measured): HPLC method according to EEC Directive 79/831, Annex V, Part A
Method: other: DIN-Standard 38412 L15 (Fish short-time test)
Kelly BC, Gobas FAPC and McLachlan MS (2004). Intestinal Absorption and Biomagnification of Organic Contaminants in Fish, Wildlife, and Humans. Environmental toxicology and chemistry Vol. 23, Part 10, pages 2324-2336.
Grant W.M., Toxicology of the eye, Second edition (1974)
Henkel KGaA, unpublished data (Reg. no. 1518)
Method: other: Daphnien-Kurzzeittest, DIN 38412 Teil 11, Bestimmung der Wirkung von Wasserinhaltsstoffen auf Kleinkrebse
Schilling, K., Kayser, M., Deckardt, K., Kuttler, K., and Klimisch, H-J. (1997) "Subchronic toxicity studies of 3-methyl-1-butanol and 2-methyl-1-propanol in rats." Human and Experimental Toxicology, 16:722-726.
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BASF AG, Department of Toxicology, Cytogenetic study in vivo|of 3-methylbuten-2-al-1 in mice Micronucleus Test, single|oral administration, unpublished report, project no.|26M0734/904515, 19 Feb. 1992
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Acute toxicity: inhalation, IUC4#43/Ch.5.1.2
Inayama Y., et al. Effects of Glycerol on 4-Nitroquinoline|1-oxide induced Pulmonary Tumorigenesis in ddY Mice, Jpn J|Cancer Res, 77:103-105, 1986 (114),
Brauwers, C. (1984): The effects of sulfurous acid and|sulfuric acid on Anabaena cylindrica (Cyanophyte). Bull.|Soc. R. Bot. Belg. 117(2), 267-276
Toxicity to aquatic algae and cyanobacteria, IUC4#100/Ch.4.3
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Geiger, D.L. et al.: Acute Toxicity of Organic Chemicals to|Fathead Minnows (Pimephales promelas), Vol 2, Center for|Lake Superior Environmental Studies, Univ. of Wisconsin,|Superior (1985).|quoted in: Protic, M. and Sabljic, A.: Aquatic Toxicol. 14,|47-64 (1989)
ACUTE TOXICITY OF HTH TO BLUEGILL, RAINBOW TROUT AND THE|WATER FLEA, E G & G, BIONOMICS, AQUATIC TOXICOLOGY|LABORATORY, WAREHAM, MA. JULY, 1977.
Dowden. B.F. (1961). Cumulative toxicities of some inorganic|salts to Daphnia magna as determined by median tolerance|limit. Proc- La. Acad. Sci. 23:77-85.
Kirchner S., 1998, Mutagenicity evaluation of Ro-8282/000 in the Ames test, Roche
National Institute of Environmental Research (NIER), 2002. Calcium sulfate dihydrate: Acute dermal irritation/corrosion study in Rabbits (Test No. BO2112), Tested by Biotoxtech, Korea.
Kuehn, R. et al.: Schadstoffwirkungen von Umweltchemikalien|im Daphnien-Reproduktions-Test als Grundlage fuer die|Bewertung der Umweltvertraeglichkeit in aquatischen|Systemen. UFOPLAN Nr. 106 03 052 des BMU, Maerz 1988
Method: other: UBA-Verfahrensvorschlag (vorlaeufiger) "Verlaengerter Toxzitaetstest bei Daphnia magna" (Bestimmung der NOEC fuer Reproduktionsrate, Mortalitaet und den Zeitpunkt des ersten Auftretens von Nachkommen; 21d) (1984)
BASF AG, Laboratory of Ecology, unpublished data, |(24.01.90)
Method: other: ISO/DIS 8192 Part B, draft
IRDC (1976) Eye Irritation Study in Rabbits. International|Research and Development Corporation (IRDC). Study #:|378-001. Study Date: July 15, 1976.
Short-term toxicity to fish, IUC4#190/Ch.4.1
BASF AG (2003a). Isobutylidene-Di-Urea. Combined Repeated|Dose Toxicity Study with the Reproduction/Developmental|Toxicity Screening Test. BASF Project No. 95RO113/009039, 22|May 2003.
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Method: other: A pre-incubation assay method was used.
Sixt S and Altschuh J (1996). Prediction of luminescent|bacteria toxicity using quantum chemical descriptors: Test|of a classification scheme. Quantitative Structure-Activity|Relationships in Environmental Sciences VII, D. Reidel Publ.|Co, Dordrecht, 343-362.
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Huels AG (1981). Solvents / Isophorone - Huels Data sheet|2257, Huels AG, Marl.
Baglay A.K., Gurarly L.L. and G.G. Kuleshov, 1988, Physical|properties of compounds used in vitamin synthesis, J. Chem.|Eng. Data, 33, 512-518
Method: other (calculated): AOP Computer Program, Vers. 1.90, integrated in U.S. EPA's EPI program Vers. 3.10
Litton Bionetics, Inc. Project No. 20988, February, 1983.
National Toxicology Program (1989). Inhalation Developmental|Toxicology Studies: Teratology Study of Isoprene in Mice and|Rats. TER88045; NTIS#DE89008095.
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BASF AG, Experimental Toxicology and Ecology,|3-methyl-2-buten-1-al: Determination of the Inhibition of|Oxygen Consumption by Activated Sludge in the Activated|Sludge Respiration Inhibition Test, unpublished study|00/0680/08/1, 30 Sep. 2002
Toxicity to microorganisms, IUC4#11/Ch.4.4
CCR (Cytotest Cell Research GmbH & CoKG): unpublished report|CCR No. 291407, ZHT Proj. No. 40MO502/919014 (sponsored by|BASF AG, Germany, Nov. 10, 1992)
Sanofi Recherche (1993). Laurolactam - three-month oral|toxicity study in the rat. Report RS0006921130/01|(unpublished)
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Method: other: Bacterial gene mutation assay
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Liber et al., 1989, Formaldehyd-induced and spontaneous|alterations in human hprt DNA sequence and mRNA expression,|Mut. Res. 226, 31 - 37, No information
Genetic toxicity in vitro, IUC4#317/Ch.5.5
Reported in AIDA-ALSTOFF INFORMATION Date Bank (13/11/92)|from McGaughy C. and J.L. Jensen (1980). Oncology, |37:65-70.
Reported by Kennedy G.L. (1986), CRC Crit. Rev. Toxicol.,|17: 129-182 from Du Pont, Haskell Laboratory, Unpublished|Data:short-term toxicity.
Method: other: an excess of the test substance was sealed into a 120 l chamber for 24 hrs, the saturation conc. at 22 °C were calculated from Antoine equation, whole body exposure, post exposure observation 14 d, gross pathological examination
Method: other: calculated with PCKOCWIN, vers. 1.63
Allyl Alcohol Consortium (2004b) Preliminary Reproduction|Toxicity Screening Study of Allyl Alcohol. Mitsubishi|Chemical Safety Institute Ltd. Study No B040554, unpublished|data
Penninks, A.H. and W. Seinen. 1982. Comparative toxicity of alkyltin and estertin stabilizers. Food and Chemical Toxicology. 20:909-916.
Solubility in organic solvents / fat solubility, IUC4#30/Ch.2.6.1
Dow Corning Corporation Internal Report Number|1982-I0065-4122-08
Bio-Research Laboratories, LTD.: Project No. 81311,|22.12.1983
Hüls AG (1988). Daphnientest nach DIN 38412 Teil 11 -|Kurzzeittest. Report No. D 371 (unpublished)
Fujita, T., Iwasa, J., Hansch C. A New Substituent Constant, Derived from Partition Coefficients. J. Am. Chem. Soc. 86, 5175-5180, 1964
Toxicity to terrestrial plants, IUC4#22/Ch.4.6.2
TSCATS, Doc.I.D. 878212151, OTS 84003A, Celanese Chem Co|Inc. (1972)
Skin irritation / corrosion, IUC4#19/Ch.5.2.1
As cited in IUCLID database, no primary reference available
CIT (1994) Skin sensitization test in guinea-pigs with 2-ethylhexyl thioglycolate, CIT study no. 10268 TSG, 14 February 1994.
Malley L.A., Kennedy G.L., Elliott G.S., Slone T.W., Mellert|W., Deckardt K., Kuttler K., Hildebrand B., Banton M.I.,|Parod R.J., Griffiths J.C. (2001) Chronic toxicity and|oncogenicity of N-Methylpyrrolidone in rats and mice by|dietary administration, Drug Chemical Toxicol., 24, 315-338
Urano, Kato (1986): J. Hazard. Mater. 13, 147-159
Biodegradation in water: screening tests, IUC4#52/Ch.3.5
S. typhimurium TA 98, TA 98 NR and TA 98/1,8-DNP6
IIT Research Institute. 1992. Determination of the|Octanol/Water Partition Coefficient of Isophthalic Acid|(IPA). Study No. 1705.
Ma, T.H. et al.: Environ. Mutagen. 9, 65-66 (1987);|abstractno. 167, No information
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Hooftman, R.N. and J.M. de Wolf. 2003. Dichlorodioctylstannane (CAS # 3542-36-7): Semi-static acute toxicity test with the crustacean species Daphnia magna. TNO Report No. V2497/02. August 2003.
SRC (1994a). KOWWIN (Octanol-Water Partition Coefficient|Program for Microsoft Windows 3.1). Syracuse Research|Corporation, Syracuse, NY.
Method: other (calculated): according to Howard & Meylan
Appearance/physical state/colour, IUC4#12/Ch.1.1.1
Legiec, C. et al. (1996) Alergia kontaktowa lekowa u chorych|z owrzodzeniami i wypryskiem podudzi, Przeglad|Dermatologiczny|83, 371-375
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Sisti R. (2001), 2-nitroaniline. Combined repeated toxicity|and screening for reproduction and development (OECD 422).|RTC Study Report No 8365/T/222/2001. Unpublished.
MHLW, Japan (2004a) Ministry of Health, Labour and Welfare: Single dose oral toxicity test of 4-Methylbenzoic acid in rats. Japan Toxicity Testing Reports of Environmental Chemicals, 11, 201-203.
Davis, D.D., Chameides, W.L., and Kiang, C.S.: Nature|295:186 (1982).
Solubility in organic solvents / fat solubility, IUC4#50/Ch.2.6.1
Fujii, T. and Nishimura, H.: Okajimas Folia Anat. Jpn. 46,|167-175 (1969)
Banage WB and Visser SA (1965). The effect of some fatty|acids and pH on a soil nematode. Nematalogica 11, 255-62.
Kao AS (1994). Formation and removal reactions of hazardous|air pollutants. J. Air Waste Manage. Assoc. 44, 683-696.
Phototransformation in air, IUC4#60/Ch.3.1.1
Ministry of Health & Welfare, Japan (1996b): Toxicity|Testing Reports of Environmental Chemicals, vol.4 p107-110,|"Reverse Mutation Test of 2-Amino-5-methylbenzenesulfonic|acid on Bacteria".
Method: other: OECD Test Guidelines 471 and 472 "Genetic Toxicology (Salmonella typhimurium and Escherichia coli)
South Charleston Technical Center Aquatic Laboratory,|(1993). Summary of Ecological Fate and Effects Data: Silane|A-1120, EFED3.
CERI (1995) Chemicals Evaluation and Research Institute|(Kurume, Japan) Test No. 51203B
Exxon Biomedical Sciences, Inc. (1999) Fish Acute Toxicity|Test. 118358.
Beezer AE, Hunter WH, Storey DE (1980) Quantitative structure activity relationships: the Van't Hoff heats of transfer of resorcinol monoethers from water to n-octanol. Journal of Pharmacy and Pharmacology 32:815-819.
US AFDO (1959) Appraisal of the Safety of Chemicals in Food, Drugs and Cosmetics
Manios VI, Tsikalas PE, Siminis HI, and Verdonck O (1989).|Phytotoxicity of olive tree leaf compost in relation to the|organic acid concentration. Biological Wastes 27, 307-317.
Sasaki,S., The Scientific Aspects of the Chemical|Substances Control Law in Japan, in: Hutzinger,O. |et al.(eds.), Aquatic Pollutants: Transformation and|Biological Effects, Pergamon Press, Oxford, 283-298, |(1978)
Petrosyan FR, Gizhlaryan MS (1983). Local effect of 1,4-dichlorobutene after application on intact skin. Biol. Zh. Arm. 37, 486-489.
Akzo Chemicals BV (1990) Acute Toxicity of Methyl Ethyl|Ketone Peroxide in Phthalate Plasticizer to Fish.|Study/Project#: CRL F90017; Project T89-6-1.9. Study Date:|1/15/90.
CIT (1995) Reverse Mutation Assay on Bacterial|Salmonella typhimurium with isooctyl thioglycolate. CIT|report no. 12571 MMO, 19th July 1995.
Wang X (2002) Structure-activity relationships and|response-surface analysis of nitroaromatics toxicity to the|yeast. Chemosphere 46: 1045 - 1051
Degussa AG, Safety Data Sheet: Sodium persulphate,|13-12-2000.
Method: other: BBA Nr. IV-4-1 part 2 adopted Dec. 1986 "Biodegradation in soil"
Hankinson, G.J. and Sakal, L. 1991. |1,2,4-benzenetricarboxylic acid (trimellitic acid) four-week|oral toxicity study in the rat. Final Report. HAEL NO.|86-0149G1.
Ellington JJ (1989). Hydrolysis rate constants for enhancing property-reactivity relationships. Environmental Research Laboratory Office of Research and Development U.S. Environmental Protection Agency Athens, Georgia 30613. EPA/600/3-89/063.
U.S. EPA (Environmental Protection Agency) (1978).|Isophorone: Ambient water quality criteria, Report No.|PB-296 798, U.S. Department of Commerce / National Technical|Information Service.
Anderson BG (1946). The toxicity thresholds of various|sodium salts determined by the use of DAPHNIA MAGNA. Sewage|works J., 18, 82-87.
Method: other: according to Anderson et al. (1944)
Method: other: 10 or 20 rats/dose, 3 doses, subst.(solved in polyethylene glycol 400) appl. on the shaved back for 24 hours, covered by alu and a plaster, then rinsed with water and soap, post exposure observ.-time: 14 d
Schnoeckel H, Schunck S (1987). Hochtemperaturhydrolyse von|PCl3 und PBr3: IR-spektroskopischer Nachweis der|matrixisolierten Moleküle OPCl und OPBr. Z. anorg. allg.|Chem. 548, 161-164.
E.I. du Pont de Nemours and Company, Inc. (1989) Static|Acute 48-hour EC50 of chlorodifluoroethane to Daphnia magna.|Report N° 542-89 Haskell Laboratory for Toxicology and|Industrial Medicine Newark, Delaware
Method: other: OECD guideline 202 (1984) and EPA Guideline 72-2 (EPA, 1982)
Gurova GV, Krasnov SK, Mazmanidi ND (1970). Effect of some|phosphorus halides on fish in ontogenesis (original|reference in Russian, cited according to German|translation). Vop. Vod. Toksikol., 136-141.
Method: other: specific investigation of changes of biochemical and cellular lung functions
Heyden Newport (1958). In: TSCATS Doc#86-920000008: Letter|from Eastman Kodak Company|to USEPA submitting enclosed Toxicity & Health Hazard|Summary, Material Safety Data Sheet & Toxicity Reports on|3-hydroxy-2-naphthoic acid, 01 Oct 1991
Jenner PM, Hagan EC, Taylor JM, Cook EL, Fitzhugh GG (1964).|Food Flavourings and Compounds of Related Structure. I.|Acute Oral Toxicity, Food and Cosmetics Toxicology 2,|327-343
Clariant GmbH (2000): Unveröffentl. Untersuchung der|InfraServ Gendorf, FB Umwelt, Abbau von Genamin LA 302 D,|(00/013-02), 9.08.00
Biodegradation in water and sediment: simulation tests, IUC4#11/Ch.3.5
Ohnishi R and Tanabe K (1971). A new method of solubility|determination of hydrolyzing solute - Solubility of benzyl|chloride in water. Bull. Chem. Soc. Japan 41, 2647-2649.
Karmazin V.E. (1966), Vopr. Kommunal'n Gig., 6, 108-11.
BUA (2005): Benzenesulfonic acid,|2,2'-(1,2-ethenediyl)bis[5-[[4-(4-morpholinyl)-6-(phenylamin|o-1,3,5-triazin-2-yl]amino]-, disodium salt. Calculation of|indirect photodegradation with SRC-AOPWIN v1.90 (2000).
BASF AG (1994) Sicherheitsdatenblatt Solvenon PM, 28.02.1994.
FMC Corporation, unpublished, FMC study no.: I91-1201|(1991).
Elf Aquitaine Production, unpublished data. THIODIGLYCOL.|Skin sensitization test in guinea-pigs. CIT Study No.|16102 TSG. 28 April 1998.
Method: other: OECD Guide-line 406, 1992
DOW Chem. Co. (1957) The toxicity of p-chlor-o-nitroaniline,|o-chlor-p-nitroaniline, 2,5-dichlornitrobenzene and|3,4-dichlornitrobenzene (OTS0535413, 86-920000855S)
Method: other: exposure duration: 24 hours
Bayer AG (1973). Internal information card of C.I.|Fluorescent Brightener 28/113 (100 % Na-salt).
Biodegradation in water: screening tests, IUC4#50/Ch.3.6
BASF AG, Dept. of Ecology, unpublished data on the toxicity|of Glyezin A in the cell multiplication test according to|Brinkmann-Kuehn, Report No.: 9/1009/88, 08. Sept. 1988
Method: other: DIN 38412, part 8 (Draft); Inhibition of cell multiplication
Inai, K. et al. (1988): Jpn. J. Cancer Res. (Gann) 79, |49 - 58
Repeated dose toxicity: oral, IUC4#33/Ch.5.4
Mueller, W.U. et al.: Teratogen. Carcinogen. Mutagen. 5,|123-131 (1985);|cited in: RIFM database, location no. 2138
Method: other: Proposal of German UBA: "Lethal effects on zebra fish Brachydanio rerio"
Ciba (1989f). Test for Acute Toxicity of Metilox (TK 10027)|to Zebra-Fish (Brachydanio rerio). Unpublished report #|894084. May 25, 1989.
The Chemical Database, The Department of chemistry at the University of Akron. 2006. http://ull.chemistry.uakron.edu/erd/index.html.
Chemicals Evaluation and Research Institute (CERI), (2004).|SRC-MPBPWIN v1.40.
NIOSH (2004). International Chemical Safety cards|http://www.cdc.gov/niosh/ipcsneng/neng1339.html.
ABC Laboratories. Acute Toxicity of TBP to Fathead Minnows. Study ID: AB-78-1384337-1c. Monsanto study AB-78-0386. (1978)
Method: other: method similar to OECD 203
Aspergillus nidulans (Diploid strain 35 x 17)
Toray Industries Inc. (1982) Report on Salmonella|mutagenicity test of 11-aminoundecanoic acid, 5 march 1982.
Method: other: equivalent to OECD Guide-line 472
Ciba-Geigy Ltd., Reproduction study - TK 10044, rat, Seg.|II, No. of experiment 227513, 19.6.1975.
Method: other: mainly according to OECD 414 (1981)
Shah JK, Sayles GD, Suidan MT, Mihopoulos P, Kaskassian S|(2000). Anaerobic bioventing of unsaturated zone|contaminated with DDT and DNT. Water Sci. Technol 43, 35-42.
Method: other: Anaerobic bioventing in soil columns
Biodegradation in water: screening tests, IUC4#41/Ch.3.5
Briggs GG (1981) Theoretical and Experimental Relationships|between Soil Adsorption, Octanol/Water Partition|Coefficients, Water Solubilities, Bioconcentration Factors,|and the Parachor. J Agric Food Chem 29: 1050 - 1059
Food and Drug Research Laboratories (FDRL), Evaluation of|the safety of NMP in Wistar-derived rats following 90-day|administration in the diet, unpublished|study, Lab. No. 5026, 09 Dec. 1976 (submitted to GAF Corp.,|ISP inventory No. 1976-005-01)
Repeated dose toxicity: oral, IUC4#21/Ch.5.4
Krivanek N.D. et al.: Toxicologist, 3, 144, (1983);|abstract no. 573, No information
Kuhlmann A (1999) Moeglichkeiten des mikrobiellen Abbaus von|Chlornitrobenzolen. Wasser, Abwasser 140: 470 - 471
Method: other: degradation in adapted batch cultures
Biodegradation in water: screening tests, IUC4#85/Ch.3.5
Method: other: comparable to OECD Guide-line 412
Mohr KL and Working PK (1988) Testicular toxicity of the|chloronitrobenzenes. The Toxicologist 8(1): 15 (Abstr.)
Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA1538; Escherichia coli WP2 uvrA (trp-)
v. Preyss, J.A. (1962), Allergie gegen Lösungsmittel,|insbesondere Terpentinöl, Berufsdermatosen 10, 214-217
Boeeseken et al. (1940): Recl. Trav. Chim. Pays-Bas 59,|1062: zitiert in: Datenbank Beilstein
BASF (1985) "Pruefung der biologischen Abbaubarkeit von 1-Methoxypropanol 2 im modifizieten OECD-Screening Test", unpublished report of BASF Germany, Ludwigshafen.
MacPhee C and Ruelle R (1969). Lethal Effects of 1888 Chemicals upon Four Species of Fish from Western North America. Univ. of Idaho Forest, Wildl. Range Exp. Station Bull.No.3, Moscow,ID, 112 p.
Interactive Analysis Program (http://ww.logp.com)
Method: other: calculated: Interactive Analysis Program (assumes no hydrolysis)
Method: other: Estimation using BCFWIN (ver. 2.14)
USEPA. 2000. WSKOW. Version 1.41. EPIWIN (Estimation Program Interface for Windows). Version 3.12. Office of Pollution Prevention Toxics (OPPTS) and Syracuse Research Corporation.
Method: other: chamber of 14.5 m3 volume; air flow: 2200-2900 l/min
Ministry of Environment (MOE), Korea (1997), Toxicity evaluation of existing chemicals (X)(ES-010)
Method: other: Testing of industrial chemicals (Ministry of Environment), Korea
Method: other: No specific protocol guideline specified. Study was conducted in 1981, prior to standardized protocols.
Alsop, G.M. et al. (1980): Bacterial growth inhibition test.|J. Water Pollut. Control Fed. 52, 2452-2456
Battelle Europe. 1993. A study of the Acute Toxicity to|Fish (Leuciscus idus melanotus) of Isophthalic Acid.
Al' meev, K.S. and Karmazin V.E. (1969) Pathomorphological changes in the organs of animals under the impact of allyl alcohol and allyl chloride. Faktory Vnesh. Sredy Ikh. Snach. Sdorov'ya Naseleniya, 1, 31-35.
Toxicity to microorganisms, IUC4#42/Ch.4.4
Kühn, Birett: Merkblätter gefährlicher Arbeitsstoffe, 10th|Ed. 1992, Ecomed Verlag, Stand: 1. April 1994.
Skin irritation / corrosion, IUC4#26/Ch.5.2.1
Hüls Infracor (1998). VESTAMIN IPD - Determination of the|partition coefficient (log pow), shake flask method. Report|No. AN-ASB 0093 (unpublished).
Adema,D.M.M., Tests and desk studies carried out by MT-TNO|during 1980-1981 for Annex II of Marpol, Report CL82/14;|(1982); zitiert in ECDIN 09/1993
BASF AG (1983), Dampfdruck N-Methylpyrrolidon, unpublished|study No. 123.025.1, 11 Aug 1983
Howard, P.H. (ed.) 1990. Handbook of Environmental Fate and|Exposure Data for Organic Chemicals, Volume II. Lewis|Publishers, Chelsea, Michigan.
Reynolds T (1978) Comparative Effects of Aromatic Compounds on Inhibition of Lettuce Fruit Germination. Ann Botany 42:419-428 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Jiang et al. (1983), Toxicol Appl Pharmacol, 71, 225-236.
Schering AG. Acute immobilization test of mono-n-octyltin trichloride with Daphnia magna. Research Report No. IC16. August 1998.
Method: other: OECD 202 and EC Guideline 92/69/EEC
Bayer Chemicals (2004). C.I. Fluorescent Brightener 28/113 -|Internal data on production, processing, use pattern, and|workplace exposure (unpublished).
Juhnke I and Luedemann D (1978). Ergebnisse der Untersuchung|von 200 chemischen Verbindungen auf akute Fischtoxizitaet|mit dem Goldorfentest. Z. Wasser- Abwasser-Forsch. 11 (5),|161-164.
Henkel Brochure (undated), Soluble Silicates. Henkel KGaA,|Duesseldorf, Department Silicates, 1-28.
Hoechst AG. 1977. Unveroeffentlichte Untersuchung [unpublished study] (20.05.1977)
I.E.Wallen et al., Sewage and Industrial Wastes; Jun.1957|vol.29, No.6: p695-711
Römpp Chemie Lexikon (1991). 9th edition, Volume 4. Edited|by Falbe J and Regitz M. Georg Thieme Verlag, Stuttgart,|2761.
Melting point/freezing point, IUC4#17/Ch.2.1
Ohara N, Takashima H, Tanaka A, Katoh H, Seki T, Kojima K,|Inada H, Anjo T, Azegami J, Yoshimura S, Saegus K (1998).|Twenty-eight-day repeat oral dose toxicity test of|dicyclohexylamine in rats. Ministry of health and Welfare|(MHW, Japan) Toxicity Testing Reports of Environmental|Chemicals Vol. 6, 101-104, 105-116, 637-642.
Method: other: Guidelines for 28 day Repeat Dose Toxicity Test of Chemicals (Japan)
Chou CH, Patrick ZA (1976) Identification and phytotoxic activity of compounds produced during decomposition of corn and rye residues in soil. Journal of Chemical Ecology 2(3):369-387.
Ishidate M Jr (1988) Data Book of chromosomal aberration|test in vitro, Revised Edition, Elsevier, Amsterdam, New|York, Oxford: 418-419
Genetic toxicity in vitro, IUC4#102/Ch.5.5
Nowakowska-Waszczuk A, Zakowska Z, and Jakubowska J (1970).|Effect of volatile acids on acid-forming ability of |Aspergillus terreus. Rocz. Technol Chem Zywn 19, 47-57.
Repeated dose toxicity: inhalation, IUC4#24/Ch.5.4
Shimizu, M. et al.: Mutation Research 116, 217-238 (1983)
Method: other: according to: OECD Guide-line 471: pour plate method, highest dose cytotoxic, performed in duplicate and repeated at least 2 times, solvent and positive control
Monsanto Co (1982) A Teratogenic Study in rabbits with|p-Nitrochlorobenzene. Project No. 80-2522 (BD-80-530), Final|Report, Contractor: Bio/dynamics Inc., report submitted to:|Monsanto Co., Date: March 11, 1982, EPA-OTS0557074
Method: other: according to OECD Guide-line 414 see also freetext ME
Gelest, Inc. Material Safety Data Sheet. Octyltrichlorotin 95% - SNO6714. Online catalog. http://www.gelest.com/gelest/gelest1/msds.asp?SNO6714 (accessed December 2, 1999).
TSCATS: OTS0545878, Doc I.D. 89-940000010, Bushy Run Res|Ctr, Report no. 92U1194, sponsored by Union Carbide Corp.,|22 Sep. 1993
Budavari S. et al., The Merck Index, An Encyclopedia of|Chemicals, Drugs, and Biologicals, Eleventh Edition, p.|1469-1470, Merck & Co., Inc., Rahway, N.J., U.S.A (1989)
Environment Agency of Japan (1999b). Acute Toxicity of|5-Ethylidene-2-Norbornene for Daphnia magna. Report 92066.
Bayer AG 1986, Internal Study, Chronic toxicity of|2,6-Bis(1,1-dimethylethyl)-4-methylphenol in the daphnia|reproduction test. Test report from 05.02.1986
Method: other: OECD Guide-line 202, part 2 " Daphnia sp. , Reproduction Test (1984)
Toxicity to microorganisms, IUC4#110/Ch.4.4
Fouillet X, Gutty D, BarretJ (1983) Report on a study of the|mutagenic potential of mucochloric acid (Ames test).|Battelle, Geneva Res. Centres, Carouge-Geneva, Switzerland;|sponsor: Rhone Poulenc
CERI (1999). Report No. 91532. Test on acute toxicity to|Daphnia magna. Chemicals Evaluation and Research Institute|of Japan.
Bogajewski, J. & Bogajweska, G (1982) Mutat. Res 97:173-174
Daubert TE, Danner RP, Sibul HM, Stebbins CC (1995). Physical and thermodynamic properties of pure chemicals - Data compilation. Washington, D.C, Taylor and Francis.
Budavari S (1989) The Merck Index (11. ed). Merck & Co,|Rahway NJ
Solubility in organic solvents / fat solubility, IUC4#5/Ch.2.6.1
Aldrich Handbook of Fine Chemicals and Laboratory Equipment (2000-2001) (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com)
Yalkowsky,S.H. & Dannenfelser, R.M.: Aquasol database of|aqueous solubility. Version 5; College of Pharmacy,|University of Arizona-Tucson, AZ. PC Version (1992); cited|in SRC PhysProp Database,|http://esc.syrres.com/interkow/webprop.exe, 27 May 2004
Amoco Corporation (1973) 4-Week Inhalation Toxicity Study of|Terephthalic Acid (TA) In Rats. Conducted by IIT Research|Institute. IITRI Study #1104
The Dow Chemical Company (2002). Dow isophorone exposure|questionnaire (unpublished).
Infracor GmbH (2000). Löslichkeits- und Abbauverhalten von Isophorondiisocyanat (IPDI) in Wasser. Communication Dr. W. Schleich to Degussa AG dated 26 June 2000 (unpublished).
Method: other: Simplified preliminary tests based on OECD Test Guidelines 105 (water solubility) and 111 (hydrolysis as a function of pH) as well as on corresponding EU methods
CARPENTER, C.P., WEIL, C.S., & SMYTH, H.F., Jr (1974) |Range-finding toxicity data. Toxicol. appl. Pharmacol., 28:313-319.
Repeated dose toxicity: inhalation, IUC4#15/Ch.5.4
Kromann A, Christensen TH (1998) Degradability of organic|chemicals in a landfill environment studied by in situ and|laboratory leachate reactors. Waste Manage Res 16: 437 -|445.
Method: other: according to Kromann and Christensen. Waste Manage Res. 16(5), 437-445
Wellens H (1990). Zur biologischen Abbaubarkeit mono- und|disubstituierter Benzolderivate. Z. Wasser- Abwasser Forsch.|23 (3), 85-98.
Biodegradation in water: screening tests, IUC4#60/Ch.3.5
DePass L. et al.: J. Tox. Envir. Health 14, 115-120, (1984)
Matsuda, S., H. Matsuda, N. Iwamoto, and A. Matsumoto. 1967. Kogyo Kagaku Zasshi. 70:1747-1750; C.A. 68 [1968] Nr. 87373.
CRC Handbook of chemistry and physics, CRC Press, 1999/2000.
American Cyanamid Co. / Bio-Research Laboratories Ltd. (1992). The acute toxicity of inhaled isophorone diisocyanate in the guinea pig. NTIS/OTS Microfiche 0543418, Doc 86-930000052.
Wallen, J. et al. (1957): Toxicity to Gambusia affinis of|certain pure chemicals in turbid waters. Sewage Ind. Wastes|29(6), 695-711
Fox, N. (1939), The Effect of Camphor, Eucalyptol and|Menthol on the Nasal Mucosa, Arch. Otolar. 11, 48-54
Method: other: calulated using ECOSAR (ver.0.99g)
Dashiell, O.L. and Kennedy, G.L. jr.: J. Appl. Toxicol. 4|(6), 320-325 (1984);|cited in: RIFM database, location no. 2295
N-(4-aminophenyl)aniline (IUC4 DSN 3013)
Chemische Werke Hüls AG (1979). Ames-Test - getestete Substanzen TMD, MNDA, Isophoron, Diaminodurol, IPD, IPDI. Internal report (unpublished).
Method: other: Ames BN et al. (1975). Mutat. Res. 31, 347-364
Matthews E. J., Environm. Health Perspec. 101 [Suppl 2],|347-482 (1994)
Method: other: Matthews E.J.,J. Tissue Culture Methods 10, 157-164 (1986),Matthewy E.J. et al., Environm. Health Perspect. 101 [Suppl 2], 319-345 (1993)
RCC Ltd. (2005) 3-Mercaptopropanoic Acid Methyl Ester (MMP):|Toxicity to scenedesmus subspicatus in a 72-hour algal|growth inhibiton test. RCC Study Number 858405. December 1,|2005.
US Department of Health and Human Services (1992) National|Toxicology Program, NTP Technical report on toxicity studies|of o-, m-, and p-Nitrotoluenes, administered in dosed feed|to F344/N rats and B6C3F1 mice. NTP technical report series|23 (author: Dunnick JK), NIH Publ.-No. 96-3346
Method: other: protocol presented by Myhr et al., Prog. Mutat. Res. 5, 555-568 (1985), highest dose was determined by limit of solubility and toxicity, colony size not reported (see also freetext Method)
Stratton, G.W. und Corke, C.T., Environmental Pollution|(Series A) 29 (1), 71-80 (1982)
Dillingham EO et al.: Acrylate and methacrylate esters:|Relationship of hemolytic activity and in vivo toxicity. J.|Biomed. Mat. Res. 17, 945-957 (1983)
Bootman, J., May,K., (1985). Mutagenicity studies. Ames test. Report, December 1985. Life |Science Res.Ltd. UK.
Method: other: Not specified; description is from a ECETOC monograph review.Tests were repeated twice with each Salmonella strain.
Janicki, R. H.: Renal adaptation during chronic NH4Cl|acidosis in the rat: no role for hyperplasia, Am. J.|Physiol., 219, 613-618,(1970)
Weinstein, D. et al.: Mutat. Res. 46 (4), 297-304 (1977);|and cited in: RIFM database, location no. 7197
CIBA-GEIGY, Ltd. 1984. Autoradiographic DNA Repair Test on Rat Hepatocytes. Test No. 830520. 28.11.1984.
Rao KV, Raviprasad A and Chiranjivi C (1979) Isothermal|Vapor-Liquid Equilibria of Allyl Alcohol-Toluene at 90 C. J.|Chemical and Engineering Data, 24 (4), 272-274
Method: other: Rohm&Haas Toxicity Screening Protocol (1972)
McGregor, D.B. et al.: presented at the the 7th Int. Symp.|Chem. Toxicol. Aspects Environ. Quality 7-10 Sept (1981);|cited in: RIFM database, location no. 10666
Method: other: two or four hour exposure
EU Method C.4-F (Determination of the "Ready" Biodegradability - MITI Test)
S.typhimurium TA97, TA98, TA100, E.coli WP2uvrA
Monsanto Chemical Co. (1976) unpublished study Project LBI|No. 2684 5/76. Cited in letter from BGVV 06.05.1996
Heisler E and Dickhaus S (1990). Pruefung des Produktes|Betolin K28 25% in total entsalztem Wasser auf primaere|Hautreizwirkung beim Kaninchen nach Draize. Pharmatox|Beratung und Forschung GmbH, Report no. 1-3-36-90.
Abou-Zaid, F.A. and El-Balshy, R.M.: Delta J. Sci., 17 (2),|322-354 (1993)
Smyth HF Jr and Carpenter CP. 1948. Further experience with the range finding test in the industrial toxicology laboratory. J Ind Hyg Toxicol. 30:63-68.
Gad SC, Dunn BJ, Dobbs DW, Reilly C, Walsh ASD (1986).|Development and validation of an alternative dermal|sensitization test: The mouse ear swelling test (MEST).|Toxicol. Appl. Pharmacol. 84, 93-114.
"Rat Oral Subchronic Toxicity Study Final Report. Compound: Isobutyl Alcohol." Toxicity Research Laboratories, Ltd. Muskegon, MI. TRL Study #032-002 dated 1987.
Chemfinder (2006). Database available online at|http://chemfinder.cambridgesoft.com; request dated 05 Jan|2006.
Chekhovskaya EV et al. (1973). Probl. Okr. Ispol''z. Vod.|3, 85-88
Balk, F. and Meuwsen, I.J.B. (1989) Acute toxicity of|N-aminoethylpiperazine (AEP) for daphnia. Unpublished|Report # CRL I89043 of Akzo NV.
Matsui S, Yamamoto R and Yamada H (1988). The bacillus|substilis/microsome rec-assay for the detection of DNA|damaging substances which may occur in chlorinated and|ozonated waters. Water Sci. Technol. 21, 875-887.
Method: other: Liquid Cultivation-Recombination Assay
Columbia Southern Chemical Corp.: Silene EF Ingestion|studies. Silene Bulletin No. 4, July (1957)
Bayer AG (2003). Isophorondiisocyanate (IPDI) subacute inhalation toxicity on rats, study no. T0071598. Report No. AT00440, 398 pp (unpublished).
Method: other: OECD Guide-line 412 (1981), adjusted to fulfill both the TSCA § 798.2250 as well as EU Guideline 92/69/EEC
Strange, D.C. et al. (1951): Arch. Surg. 62, 350-357; cited|in BG Chemie Toxikologische Bewertung (1991).
Bayer AG (2001). Safety Data Sheet Benzotrichloride pure,|Benzotrichloride technical. Safety Data Sheet No. 018655,|2001-11-06.
Melting point/freezing point, IUC4#12/Ch.2.1
Method: other: equivalent to OECD Guide-line 479
BCFWIN v.2.15, EPISUITE v. 3.11 (U.S. Environmental Protection Agency, 2003).
Bioaccumulation: aquatic / sediment, IUC4#20/Ch.3.7
Meng Z, Zhang L (1992) Cytogenetic damage induced in human|lymphocytes by sodium bisulfite. Mutat Res 298: 63-69
Bassendowka-Karska, E. and Zawadzka-Kos, M.: Bromatol.|Chem.Toksykol. 15, 287-290 (1982), No information
Genetic toxicity in vitro, IUC4#157/Ch.5.5
BASF AG, Department of Toxicology; unpublished data on acute|toxicity of Glyecin A; Report No.: XVI/109, 13.June 1966
Monsanto (1984) Santoflex 13 Degradation Toxicity Test with|Daphnia magna. Unpublished study MO-92-9050 (ES-80-SS-11)
Ellis, M.M. (1937) Detection and measurement of stream|pollution. In Bull. Bur. Fish., U.S. Dpt. Commerce,|Washington, D.C., Vol. 22, pp. 365-437.
Short-term toxicity to fish, IUC4#90/Ch.4.1
Esso Research and Engineering Company, Linden, N.J. /|Hazelton Labs Inc. (1964). Acute toxicity studies mice,|rats, rabbits, guinea pigs. NTIS/OTS Microfiche 0206267, Doc|878210931.
Komsta E., Secours V.E., Chu I., Valli V.E., Morris R.,|Harrison J., Baranowski E., Villeneuve D.C. (1989),|Short-term toxicity of nine industrial chemicals: Bull|Envirn. Contam. Toxicol. 43, 87-94
Budavari, S. (ed) 1996 The Merck Index. An Encyclopedia of|Chemicals, Drugs, and Biologicals. Merck Research|Laboratories, Division of Merck & Co., Inc. Whitehouse|Station, NJ.
Method: T39-05:NTP Board EPA/FDA guidelines
NTP, Technical Report Series No. 33, NIH Publication|93-3382, July/1993
Barrow RE and Smith RG (1975) Amer Ind Hyg Assoc J, May|1975, p. 398-403
Mobil International (1977). Terrell Y. Acute toxicity|studies of MCTR 190-77: Report on oral LD50 in rats. Cannon|Laboratories Inc., Edison, NJ, Report No. 7E-6993, Mobil|internal report (unpublished report).
BASF AG: Abt. Toxikologie, unveroeffentlichte|Untersuchungen, (77/618), 09.06.1978
Method: other: Guidelines for reproduction studies for safety evalutation of drugs for human use, FDA, 1966 bzw. Guidance on reproduction studies from the Association of the British Pharmaceutical Industry, 1975
Pevny, I. et al., Dermatosen 29, 123-130 (1981)
McKee and Wolf (1963) Water Quality Criteria, 2nd edition,|The Resources Agency of California, State Water Quality|Control Board, Sacramento, California
OECD TG 422, “Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test”
Developmental toxicity / teratogenicity.001
Method: other: similar to OECD Guide-line 401
Niimi, A.J. et al., Environ. Toxicol. Chem. 8 (9), 817-823|(1989)
Method: other: fish exposed to a mono- to pentachloronitrobenzene isomer mixture at the same time in a flow-through system
Mohr, K.L. and Working, P.K.: The Toxicologist 8(1), 15|(1988) (abstr.)
Method: other: 5or 6 rats, sacrifice on d1 and d25 post application, evaluation of testes weight, testicular histopathology, sperm production
Richterich, K. & Steber, J., Chemosphere 19, 1643-1654|(1989)
Method: other: Respirometer-Test (Closed Bottle Test)
Katsumura, T., H. Kataoka, and Y. Mitsuno. 1963/68. Nitto Chemical Industry Co., Ltd. U.S.P. 3390159; C.A. 69 [1968] Nr. 77506.
Hayashi, M. et al.: Fd. Chem. Toxic. 26, 487-500 (1988)
IIT Research Institute. 1991. Primary Eye Irritation Study|of TMA in Rabbits. Study No. 1693
Dybing, E. and Thorgeirsson, S.S (1977) Biochemical Pharmacology 26, 729-734.
Herrington, E.F.G., Physical Constants of Some Constituents|of Coal Tar, NPL Report No. Chem.102
Tanaka KI, Marui Sh, Mii T (1980) Mutagenicity of extracts|of urine from rats treated with aromatic amines. Mutat Res|79: 173-176
Dalhamn T. (1957). Chlorine dioxide; Toxicity in animal experiments and industrial risks. Arch Ind Health 15: 101-107
Gigiena Truda i Professional'nye Zabolevaniya (1992) Labor|Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya|Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher|information, see MTPEEI 30(5):52, 1986. Cited in NISC and|BiblioLine (2009) BiblioLine - www.nisc.com
K. Landsteiner and J. Jacobs (1936) Studies on the|sensitization of animals with simple chemical compounds. II.|Journal of Experimental Medicine, 64, 625-639.
BASF AG, department of ecology, unpublished data (1282/88),|05.10.1988
Method: other: according to Bringmann-Kühn
Bomhard, E. (1996): J. Am. Coll. Toxicol. 15, S72
Sidorov, K.K., Gorban, G.M. & Tikhonova, G.P. (1968). Comparative toxicological characteristics of some regenerable absorbers of carbon dioxide. Environmental|Space Science 2, 289-292.
HSDB (2003) Hazardous Substances Data Bank, data sheet for|Benzotrichloride
Salmonella typhimurium TA1537, TA98, TA1535, TA100
Hommel G (1997) Handbuch der Gefährlichen Güter. Springer|Verlag, Berlin, Merkblatt 361b
Hasegawa, R., Nakaji, Y., Kurokawa, Y. and Tobe, M. Acute toxicity on 113 environmental chemicals. Sci. Rep. Res. Inst. Tohoku Univ., C, 36, 10-16, 1989
Abe S and Sasaki M. Chromosome aberrations and sister|chromatid exchanges in Chinese hamster cells exposed to|various chemicals. J. National Cancer Inst. 58(5):|1635-1640, 1977.
Ballantyne B, Norris J, Dodd D, et al. (1997). Short-term|and subchronic repeated exposure studies with|5-ethylidene-2-norbornene vapor in the rat. J. of Applied|Toxicology 17, 197-210.
Dowd, Shen (1990) Entomol. Exp. Appl. 56:241-248.
Mouse lymphoma L5178Y cells heterozygous TK+/-
Parton JW, Yount Dj, Garriott M (1995) Improved sensitivity|of the unscheduled DNA synthesis assay in primary rat|hepatocytes following culture in serum-free defined media.|Environm Molec Mutagen 26: 147-154
Method: other: test substance dissolved in DMSO, DMSO control, hepatocytes cultured in serum free defined medium (WEM)
Beilstein Handbook, Registry Number: 1912834, Last Update:|2003.07.25
Microbiological and Biochemical Assay Laboratories,|ReportNo.J-0833, (1985)
Method: other: Federal Register, vol.43, no 163-Tuesday, Aug.22, 1978
BASF AG, Department of Ecology, unpublished study,|1/0012/2/88-0012/88, 05.02.1988
Engelhardt G., Fleig H. (1993) 1-Methyl-2-pyrrolidone (NMP)|does not induce structural and numerical chromosomal|aberrations in vivo, Mut. Res., 298, 149-155
Thyssen J (1979b). Bayer AG data, Untersuchung zur Haut- und|Schleimhautverträglichkeit, january/02/1979.
BASF AG, Department of Toxicology, Prüfung der akuten oralen|Toxizität an der Ratte (85/404), unpublished data, 24 Feb|1986
DuPont,, Haskell Laboratory (1994) Outside Report No. 310-94.
Yaws CL (1994). Handbook of Vapor Pressure. Volume 3 - C8 to|C28 Compounds. Gulf Publishing Company, Houston, Texas.
Report No. EFA98002, Environment Agency, Japan (1999a):|unpublished report
Gibson C.I. and al. 1976 . Some effects of temperature,|chlorine and copper on the survival and growth of the coon|stripe shrimp. pages 88-92 in: Esch G.W. and Mc Farlane|R.W., Thermal Ecology II Proc. 1975 Symp., U.S. Erda Rep. N|. Conf-750 425
sodium 1-methoxy-1-oxohexadecane-2-sulphonate (IUC4 DSN 52)
Chemicals Evaluation and Research Institute (CERI), (2004).|SRC-AOPWIN v1.90.
Genetic toxicity in vitro, IUC4#189/Ch.5.5
Lyman, W.J., et al. 1982. Handbook of Chemical Property Estimation Methods. Environmental Behaviour of Organic Compounds. McGraw-Hill. New York
Calculated using water solubility 30,900 mg/L, vapor pressure 60.37 mm Hg, and molecular weight 102.13 g/mol
Method: other (calculated): with SRC-AOPWin v1.90, 2000
Esso Research and Engineering Company (1964) Acute Oral,|Dermal, Eye Irritation and Inhalation Toxicity. Unpublished|report.
Weber RC et al. (1981) Vapour pressure distribution of|selected organic chemicals. USEPA-600/2-81-021. Cited in:|Howard PH (1989) Handbook of Environmental Fate and Exposure|Data. Vol. 1 Large Production and Priority Pollutants,|73-77. Lewis Publ. Chelsea
BASF (1989): Bestimmung der akuten Wirkung von|Natriumdisulfit gegenüber dem Wasserfloh Daphnia magna|Straus. Rep. No. 1/0897/2/88-0897/88, 1989-05-10
Keyser P, Pujar BG, Eaton RW, Ribbons DW. (1976)|Biodegradation of the phthalates and their ester by|bacteria. Environ Health Perspect 18, 159-66
Beilstein, Handbook (online), BRN 1741705, BPR 110-93-0,|update date 07 May 1999, printing date 03 July 2003
neural ganglia obtained from Drosophila melanogaster
Haarmann & Reimer GmbH (1989), Assessment of the eye|irritant effect of HR 89/620006 in rabbits, Scantox -|biological laboratory ltd lab no. 11756, 02.05.1989
Gellein M and Holst A (1996). Måling av fysikalske data for|noen formiater. Project No. R74880, Research Centre|Porsgrunn, 12 Nov 1996, unpublished.
CIBA-GEIGY, Ltd. 1986. Final Report. TK 11638/1. Acute Dermal Irritation/Corrosion Study in the Rabbit. GU Project No.: 861015. 14.10.1986.
Method: other (calculation): PCKowWin Version 1.66 as integrated in EpiWin Version 3.11 (first-order molecular connectivity index (1-MCI) method), Syracuse Research Center / U.S. EPA
Method: other (calculated): MPBPWIN (v1.41)
Little LW and Chillingworth MA (1974). Effects of 56|selected dyes on growth of the green alga Selenastrum|capricornutum. Chapter II in: Dyes and the environment,|V.II, American Dye Manufacturers Institute Inc., 5-14.
Valvani, S.C., S.H. Yalkowsky, T.J. Rosemand. Solubility and|Partitioning. IV. Aqueous Solubility and Octanol-Water|Partition Coefficients of Liquid Non-electrolytes. J. Pharm.|Sci. 70: 502-7.
Green, E.J. et al., Environ. Mutagen. 1, 399-407 (1979)
Jacobs GA, Dierickx PJ and Martens MA (1988). Evaluation of|the in vitro uridine uptake inhibition assay in comparison|with the in vivo eye irritation test as prescribed by the|EEC. ATLA(Altern. Lab. Anim.) 15, 290-296.
Method: other: experimental protocols in European Cmmunity on dangerous substances
American Cyanamid Company (1974) Combined|reproduction-teratogenicity study of Compound III in the|rat. Unpublished report prepared by Pharmacopathics Research|Laboratories cited in: Burg AW, Rohovsky MW, Kensler CJ|(1977) Current status of human safety and environmental|aspects of fluorescent whitening agents used in detergents|in the United States. CRC Critical Reviews in Environmental|Control 7: 91 - 120
Leung H-W. and Auletta C.S. (1997) Evaluation of skin|sensitization and cross-reaction of nine alkeleneamines in|the guinea pig maximization test. J. Toxicol. Cut.& Ocular|Toxicol., 16 (3), 189-195.
Method: other: according to Magnusson and Kligman
Hoechst AG (1995): Unveröffentlichte Untersuchung|(LPT-Report No. 8767/94)
Volk GM and Dudeck AE: Abnormal color response of turf|ryegrass to top-dressed isobutylidene diurea. Agron. J. 68,|534-536 (1976)
Ihara Chemical Industry Co., Ltd. (1993b) Unpublished|testing report titled "Acute dermal toxicity study of|o-chlorobenzyl chloride in albino rats.", Study No.|WIL-211002, conducted by WIL Reserch Laboratories, Inc.
Kerckaert GA, LeBoeuf RA, Isfort RJ (1998) Assessing the|predictiveness of the SHE cell transformation assay for|determining the rodent carcinogenic potential of single ring|aromatic/nitroaromatic amine compounds. Tox Sciences 41:|189-197
Method: other: according Berwald and Sachs, 1965
BASF AG (1969) Skin irritation after exposure to choline|chloride 50% powder. Department of Toxicology, Skin|laboratory, unpublished results, Study No. XIX/271,|06.08.1969
Genetic toxicity in vitro, IUC4#174/Ch.5.5
Fujita H, Sasaki M (1987) Mutagenicity test of food|additives with Salmonella typhimurium TA971 and TA102. Ann|Rep Tokyo Metr Res Lab PH 38: 423-430 (In Japanese)
Method: other: preincubation procedure as described by Ames
Hüls AG (1988). Sauerstoff-Konsumptionstest - Produktname|Laurinlactam flüssig. Report No. O 30 (unpublished)
Method: other: Test for inhibition of oxygen consumption by Pseudomonas putida (Hüls Method)
Dupont de Nemours (1949) Toxicity of compounds, including|1-Chloro- 4-nitrobenzene (p-Nitrochlorobenzen), in []|Building. 09.05.1949: EPA-OTS0557142 and EPA-OTS0557164 and|EPA-OTS0557115 and EPA-OTS0555699 and EPA-OTS0533716 and|EPA-OTS0533732
Method: other: TS administered as 20 % solution in peanut oil warmed to 50 °C, no further information
Catalog 15, Chemika-Biochemika (1986/1987) Fluka Chemical|Corporation, Ronkonkoma, NY
Salmonella typhimurium strains TA98, 100, 1535, 1537, 1538
US EPA. (2008) Estimation Programs Interface Suite™ for Microsoft® Windows, v 3.12. United States Environmental Protection Agency, Washington, DC, USA.
Method: other (calculated): using Log Kow v1.67.
BASF AG, Department of Toxicology, Prüfung der akuten|dermalen Toxizität an der Rückenhaut weißer Kaninchen|(77/213), unpublished data, 05 May 1980.
Engelhardt, D., and Hoffmann, H.D. Cytogenetic Study In Vivo with Isobutanol in the Mouse Micronucleus Test - Single Oral Administration. (2000) Project No. 26M0243/994085, Department of Toxicology, BASF Aktiengesellschaft, D-67056 Ludwigshafen/Rhein, FRG.
Grafstrom, R.C. et al.: Science 228, 89-91 (1985), No information
Meylan W. and Howard P. (1999) EPIWin Modeling Program.|Syracuse Research Corporation. Environmental Science|Center, 6225 Running Ridge Road, North Syracuse, NY|13212-2510
Method: other: (calculated) ECOSAR Program (v0.99e)
Clarke N (2005) Diammonium Dithioglycolate: Assessment of Ready Biodegradability; CO2 Evolution Test. Safepharm Laboratories Ltd, Report 1158/048 (Bruno Bock Chemische Fabrik GmbH & Co KG unpublished study).
Bykov ST (1972): Effect of beta-naphthol on the content of|nicotinic acid and its metaboites in the blood, liver and|urine and of tryptophan in the blood serum of animals.|Farmakol. Toksikol. 35(6), 731-734 (in Russian)
BioDynamics Inc. (1990). An acute inhalation toxicity study|of C-1261 in the Rat. Unpublished study report to project|No. 89-8232, dated Mai 31, 1990. Sponsored by Hoechst|Celanese Corporation, Somerville, New Jersey.
EPA OTS 798.1150 (Acute inhalation toxicity)
de Roode, D.F. and H.P.M. de Haan. 2004. 8-Oxa-3,5-dithia-4-stannatetradecanoic acid, 10-ethyl-4,4-dimethyl-7-oxo-, 2-ethylhexyl ester [Dimethyltin bis(2-ethylhexylmercaptoacetate), CAS No. 57583-35-4]: Daphnia magna, reproduction test (semi-static). NOTOX Project 375042. December 6, 2004.
Bayer Industry Services (2004b). Determination of the Water Solubility (Flask Method) of 1,4-Dichloro-2-butene. Unpublished Report, No. 04/0065/01 LEV.
Takasago International Corporation [1982 Japanese; 1999|English translation]: Toxicology studies of isophytol in the|guinea pig. Test no. 2398, unpublished.
BASF Corporation. (1992). Toxicity of Protectol PP to Algae.|Unpublished report.
EC50: based on immobilization; 21-Day LOEC: based on length, days to first brood and Y/D/D
Method: other: according to Mohn and Ellenberger in: Kilbey, B.J. et al. (eds.): Handbook of mutagenicity test procedures, Elsevier, Amsterdam; pp. 95-118
Hüls AG (1984b). Prüfung der akuten Hautreizwirkung von Isophorondiisocyanat (IPDI). Report No. 0290 (unpublished).
CIBA-GEIGY, Ltd. 1988. Report on the Alga, Growth Inhibition Test with TK 11339. Project No. 884110. Basle, Switzerland. 15.03.1988.
Masaru, N., Syozo, F., Saburo, K., Effects of exposure to|various injurious gases on germination of lily pollen.|Eviron. Pollut., 11: 181-188, 1976, No information
Waggy GT and Payne JR. 1974. Environmental impact product analysis. Acute aquatic toxicity testing. Union Carbide Corporation, Research and Development Department. Project No 910F44, dated January 25, 1974.
Method: other: as described in "Standard Methods for the Examination of Water and Wastewater", 13th edition, 1971.
Bayer AG (1978). Internal information card of C.I.|Fluorescent Brightener 28/113 (98 % Na-salt).
Biodegradation in water: screening tests, IUC4#30/Ch.3.6
Bayer AG, department of toxicology: unpublished results,|report no. 13252, 02-01-85, No information
Bayer Industry Services (2004b). Internal report No.|A04/0040/01 LEV: Determination of the water solubility|(flask method) of Blankophor BBH content of sodium and|potassium.
Method: other: Owen, W.F., Wat. Res. 13:485, 1979
Schering AG, Experimentelle Toxikologie. 1971. Systemische Verträglichkeitsprüfung an Ratten bei einmaliger p.o. Verabreichung (DL50). Di-n-butylzinnoxid. ZK-Nr.: 26.385. Prot.-Nr. 2335. Bergkamen, Germany. 1.4.1971.
Hommel G., Handbuch der gefährlichen Güter, Leaflet 493,|Springer-Verlag Berlin Heidelberg (1998)
Widdows, J. and J. Page. 1993. Effects of Tributyltin and Dibutyltin in the Physiological Energetics of the Mussel, Mytilus edulis. Marine Environ. Res. 35:233-249.
Long-term toxicity to aquatic invertebrates, IUC4#8/Ch.4.5.2
Bayer AG data: Loeser, E.: o-Nitrochlorbenzol. Untersuchun-|gen zur akuten oralen Toxizitaet an maennlichen Wistar-Rat-|ten, April 2, 1982
Method: other: 10 rats/dose, 5 doses, test subst. dissolved in lutrol, gavage: application volume: 20 ml/kg bw., observation time: 14 d, some of the rats, that died, and some of the survivors were dissected
Beilstein Database. Copyright 1988-2005 Beilstein Institut|zur Foerderung der Chemischen Wissenschaften. CrossFire|Beilstein, licensed by MDL Information Systems GmbH.
BASF AG, Department of Toxicology, Report on the|Maximization Test for the sensitizing potential of|3-Methylbuten-2-al-1 in guinea pigs, unpublished report,|project no. 30H0734/902208, 04 Oct. 1991
BASF AG (1988) unpublished investigation 0082/88.
NTP (National Center for Toxicologial Research): Evaluation|of the Effects of Prenatally Administered Caffeine On|Skeletal Development And Postnatal Function in Rats, Final|Report, NCTR Techn. Rep. for Expts. No. 6118 and 6127|(1987).
BASF AG (1987). Internal Report: Determination of the|octanol-water partition coefficient of o-toluidine. (Report|no. 87.19.1).
Method: other (measured): Directive 79/831/EEC
BASF AG, Department of Toxicology, unpublished results,|Proj. No. 21R0544/90049, 20 Aug. 1991
Developmental toxicity / teratogenicity, IUC4#19/Ch.5.8.2
BASF AG (1987). Department of Physical Chemistry, water solubility, Unpublished Report, Report No. UV 02.87, 14 September 1987.
Method: other: as described in official gazette L2251/44 EU
Gizhlaryan, M. S.(1981) Zh. Eksp. Klin. Med., 21, 590-596.
Vock E.H., Lutz W.K., Ilinskaya O., and Vamvakas S. (1999).|Discrimination between genotoxicity and cytotoxicity for the|induction of DNA double-strand breacks in cells treated with|aldehydes and diepoxides. Mutation Research 441, 85-93., No information
Genetic toxicity in vitro, IUC4#233/Ch.5.5
Kawai A, Goto S, Matsumoto Y, Matsushita H (1987)|Mutagenicity of aliphatic and aromatic nitro compounds. Jpn|J Ind Health 29: 34-54
Pachor, M.L. et al., Oral Surg. Oral Med. Oral Pathol. 67,|393-395 (1989)
Method: other: double-blind oral challange test
Haarmann & Reimer GmbH (1989), Assessment of the skin|irritant effect of HR 89/620006 in rabbits, Scantox -|biological laboratory ltd lab no. 11876, 16.08.1989
Karegoudar, Pujar. (1984): Proc. Indian Acad. Sci. (Chem.|Sci.) 93, 1155-1158
Biodegradation in water: screening tests, IUC4#43/Ch.3.5
McCormick, D.L. et al. (1986): Cancer Res. 46, 5264 - 5269
Method: other: Mammary Tumour Prevention Assay
Ciba-Geigy Ltd., Skin sensitizing (contact allergenic)|effect in guinea pigs of TK 10044, Project No Siss 4734,|6.4.1976.
Method: other: Maurer, Agents and Actions, 1975 and Appraisal of the safety of chemicals in foods, drugs and cosmetics, US AFDO, 1959.
Parker JG (1984). The Effects of Selected Chemicals and|Water Quality on the Marine Polychaete Ophryotrocha Diadema,|Water Research 18, 865-868
Initial Submission: Mutagenic Evaluation of C-533, Rigidite|5217 in the Ames Salmonella/Microsome Plate Test (Final|Report) with Enclosed Report and Cover Letter,|OTS0536939(1992)
Pagano, D. A. et al.; Mutation Research, vol. 228, 89-96|(1990).
CIBA-GEIGY, Ltd. 1980. Report on Eye Irritation in the Rabbit after Single Application of TK 10701. Project No.: 80149. 21.08.1980.
Kirsch, P., Hildebrand, B. (1987). Report on the Study of|Acute Oral Toxicity (for Solvenon PP). Unpublished report|from BASF Aktiengesellschaft, Department of Toxicology,|Project No. 10A0406/871172. November 24, 1987.
Method: other: Not specifically referenced. Generally follows OECD Guideline 401 "Acute Oral Toxicity"
McFee AF, Jauhar PP, Lowe KW, MacGregor JT, Wehr CM (1989)|Assays of three carcinogen/non-carcinogen chemical pairs for|in vivo induction of Chromosome aberrations, SCE and MN.|Environ Mol Mut 14: 207-220
Method: other: according to Latt et al 1982 in Hsu(ed.): Cytogenetic assay in environmental mutagens, Totowa N.Y.: Allanheld, Osmun, pp. 29-80, see also freetext TC
Shaver TN (1984). Fate of Ethephon and|N-methyl-2-pyrrolidone in Soil and Cotton Plants. Arch.|Environ. Contam. Toxicol. 13, 335-340.
BUA (1993). GDCh-Advisory Committee on Existing Chemicals of|Environmental Relevance (BUA) Report 114, Dinitrotoluene|Supplementary Report. S. Hirzel, Wissenschaftliche|Verlagsgesellschaft, Stuttgart.
Goldmacher, V.S. and Thilly, W.G.: Mutat Res. 116, 417-422|(1983), No information
Nehring, D.: Untersuchungen ueber die Toxizitaet neuer|Planzenschutzmittel und Abwasserstoffe gegenueber Fischen,|14, No.1-2, 1-8(1966)
Union Carbide Corp. 1946. Bushy Run Research Center, Monthly Report 5-30-46, 1946.
Allied Corporation (1976). Mutagenicity Evaluation of|Silane, Trimethoxy [3-oxiranyl|methoxy)propyl] and N-343 in the Mouse Lymphoma Assay and a|Microbial Suspension Assay, Final Report Prepared by Litton|Bionetics, Inc. Fiche Number 215156.
Neuhaeuser-Klaus, A. & Lehmacher, W., Mutat. Res. 224,|369-371 (1
LaLonde RT, Xie S, Chamulitrat W, Mason RP (1994) Oxidation|and radical intermediates associated with the glutathione|conjugation of mucochloric acid. Chem Res Toxicol 7: 482-486
Crompton Corporation (2005) MSDS HI-POINT 90. 3/22/2005.
Florin I, Rutberg L, Curvall M, and Enzell CR (1980).|Screening of tobacco smoke constituents for mutagenicity|using the Ames' test. Toxicology 18, 219-232.
Method: other: according to Ames et al. (1975). Mut. Res. 31, 347
White, R.D., Norton, R., and Bus, J.S.: [Abstract]|Pharmacologist, 24(3): A429 (1982).
Elf Atochem North America Inc., TSCAT, OTS0200125-1, Doc I.D. 88-7800055, 07 Oct. 1995
Degussa AG: Determination of the acute oral toxicity in rats|of a number of different amourphous silicic acids, and other|"white products". TNO Report No. R 6190. Unpublished report:|Degussa AG - US-IT-No. 79-0004-DKT (1979)
Lide, D.R. (ed.): CRC Handbook of Chemistry and Physics. 71th ed. Boca Raton, FL: CRC Press Inc., p. 4-6, 1990 - 1991
BASF AG (2004). Details on an inhalation risk test in the|rat, Glyecin A, BASF Report XVI/109 (June 13, 1966) and the|original laboratory raw data, unpublished report, 08 April|2004.
Borenfreund, E. and H. Babich. 1987. In vitro cytotoxicity of heavy metals, acrylamide, and organotin salts to neural cells and fibroblasts. Cell Biol. Toxicol. 3:63-73.
Cosma, G.N. et al.: Cancer Lett. 42, 13-21 (1988), No information
Genetic toxicity in vitro, IUC4#204/Ch.5.5
GAF (1979). Aquatic Toxicology Laboratory, contract No.|L1393-05, August 1979 (unpublished).
Shahin MM, Bugaut A, Gilard P, Kalopissis G (1980) Studies n the mutagenicity of resorcinol and hydroxy-3-(p-amino)anilino-6,N-[9p-amino)phenol] benzoquinone-monoimine-1,4 in Salmonella typhimurium. Mutation Research 78:213-218.
Henck JW and Lockwood DD (1978) Acute toxicological|properties and industrial handling hazards of isooctyl|thioglycolate. Unpublished Dow report.
Method: other: Guidelines for Screening Toxicity Testings of Chemicals (Japan)
Method: other: Static inhalation chamber
Acute toxicity: inhalation, IUC4#24/Ch.5.1.2
Cieszlak, F. et al., Unpublished report of The Dow Chemical|Company (Short-term inhalation in rabbits with recovery|period) (1996)
Method: other: Thirteen days inhalation toxicity study
Dow Corning Corporation (1993), An Acute Skin|Irritation/Corrosion Study of Dow Corning® Z-6079 in Albino|Rabbits. HES Study Number 7773. Report Number:|1993-I0000-38549
Janssen,C.R., Persoone,G., Environ.Toxicol.Chem.12, 711-717,|1993, No information
Hart, E.R. The toxicity and analgetic potency of salicylamide and certain of its derivatives as compared with established analgetic-antipyretic drugs. J. Pharm. Exp. Ther. 89, 205-209, 1947
Hoechst AG (1989): Produktinformation o-Nitrochlorbenzol der|Abt. Verkauf Feinchemikalien (März 1989); document not|available
Alarie, Y. (1990), Unpublished date (cited in Federal|Register, 1976) cited in Bibra, Toxicity Profiles, The|British Industrial Biological Research Association,|Carshalton Surrey, 1-9
BASF AG: Abt. Toxikologie, unveroeffentlichte|Untersuchungen, (XII/315), 03.03.1966
Heath, A.G. (1978): Influence of chlorine form and ambient|temperature on the toxicity of intermittent chlorination to|freshwater fish. In: Jolley, R.L. et al. (Eds.): Water|Chlorination Environmental Impact and Health Effects, Vol.|2, 122-132.
BASF AG (1990). Department of Ecology. Bacterial Growth|Inhibition Test, study No. 9/0290/88, 18 Dec 1990,|unpublished.
Method: other: following German Industrial Standard DIN 38412, Part 8 (draft)
Salmonella typhimurium TA 98, TA 100, TA 1530, TA 1535, TA 1537, TA 1538
Shell Research Group Report (1984). Report # SGBR.84.090,|Sittingbourne Research Centre, Sittingbourne, Kent, England.
Registry of Toxic Effects of Chemical Substances. p. 1301|1985-86.
Izmerov et al.: "Toxicometric parameters of industrial|toxicchemicals under single exposure", Moscow centre of|International Projects, GKNT, 69 (1982), No information
Short-term toxicity to fish, IUC4#64/Ch.4.1
Salmonella typhimurium TA 1535, TA 1538, TA 98, TA 100
Inversk Resarch International(IRI).(1991f), Determination of|photoirritation potential in Guinea pigs. Report No.6920,|Unpublished report
Method: T20-03:Method based on that of Harber, Armstrong and Ichikawa(JNCI, 1982,69,1)
Chemicals Inspection & Testing Institute, Japan, unpublished data (1992)
Industrial BIO-TEST Laboratories, Inc. 1958. Report to|Amoco Corporation Range-Finding Toxicity Studies on Three|Test Materials.
Genetic toxicity in vitro, IUC4#61/Ch.5.5
Suzuki Y (1985) Studies on development of the sensitive|micronucleus test (Part II) the in vitro method using|cultured bone marrow cells. Tokyo Jikeikai Med J 100: 707 -|719
Method: other: as desccribed by Suzuki Y (1985) Tokyo Jikeikai Med J 100: 707 - 719
Commission Directive of 18 November 1987 adapting to|technical progress for the ninth time Council Directive|67/548/EEC on the approximation of laws, regulations and|administrative provisions relating to the classification,|packaging and labelling of dangerous substances. Official|Journal of the European Communities 31, 76 - 78.
Method: other: modified OECD Standard Protocol
Gellert G, Stommel A (1999) Influence of Microplate Material|on the Sensitivity of Growth Inhibition Tests with Bacteria|Assessing Toxic Organic Substances in Water and Waste Water.|John Wiley & Sons, New York, pp 424 - 428
Toxicity to microorganisms, IUC4#150/Ch.4.4
Schering AG. Acute toxicity of mono-n-octyltin trichloride to the Zebra fish. Research Report No. IC18. August 1998.
Heisler E and Dickhaus S (1990). Pruefung des Produktes|Betolin K28 - 100% - auf primaere Hautreizwirkung beim|Kaninchen nach Draize. Pharmatox Beratung und Forschung|GmbH, Report no. 1-3-34-90.
Zhitkovich, A. and Costa, M.: Carcinogenesis 13, 1485-1489|(1992), No information
Method: other: K-SDS precipitation assay (DNA-protein crosslinks)
Genetic toxicity in vitro, IUC4#459/Ch.5.5
Health Council of the Netherlands (2006). Committee for|compounds toxic to reproduction. Formic acid. Evaluation of|the effects on reproduction, recommendation for|classification. Publication No. 2006/02OSH, dated June 13,|2006. Available at www.gr.nl.
BASF (Schweiz) AG (1993). Sicherheitsdatenblatt Isophytol,|ME 00150. v.3. 30.08.1993.
US DHEW. 1978. Registry of toxic effects of chemicals,|Washington DC, US Department of Health, Education and|Welfare. As cited in World Health Organization (WHO). 1987.|Environmental Health Criteria 65: Butanols - Four Isomers:|1-Butanol 2-Butanol tert-Butanol Isobutanol. WHO. Registry|of Toxic Effects of Chemical Substances. p.1301, 1985-86.
Skin irritation / corrosion, IUC4#40/Ch.5.2.1
Woodiwiss FS and Fretwell G (1974) Water Pollut Control,|73,396-405
Short-term toxicity to fish, IUC4#53/Ch.4.1
TSCAT, OTS 0571381, Doc.I.D. 88-920009724, submitted by|Rhone-Poulenc Inc., Sponsor Rhodia Inc., Oct. 21, 1992
BASF AG, Department of Toxicology, unpublished results|(XIX/422), 03 June 1970
Landsteiner K and Jacobs J (1936) Studies on the|sensitization of animals with simple chemical compounds. J|Exp Med 61: 643 - 656
CIIT (1993): A chronic inhalation toxicity study of chlorine|in female and male B6C3F1 mice and Fisher 344 rats, Report,|December 1993
Method: other: generally followed OECD 453 Combined ChronicTox/Carcinogenicity Study.
Method: other: data reported from Japanese industry
Hazelton (1982) Submission of data by CTFA. Code No. 2-23b-22; cited in: Liebert (1986) and Spengler et al. (1986).
Simmon VF (1979) In vitro assays for recombinogenic activity|of chemical carcinogens and related compounds with|saccharomyces cerevisiae D3. J Natl Cancer Inst 62: 901-909
Bayer AG 1987, Internal study: Prolonged toxicity test with|Brachydanio rerio (1987.02.19)
BASF AG, Department of Toxicology, unpublished results,|Proj. No. 26M0369/884156, 07 March 1989
BASF AG, Analytical Department; unpublished data (Fixapret|CPN 45%), (J.Nr. 12501; 22.07.74)
Melting point/freezing point, IUC4#19/Ch.2.1
Thatcher, T.O.(1978): The relative sensitivity of pacific|northwest fishes and invertebrates to chlorinated sea water.|Proc. 2d Conf.Water Chlorination, Environ.Impact and health|effects, vol.2, Oct.31 to Nov.4, 1977, Gatlinburg,TN:|341-350.
Hellwig, J., Hildebrand, B., (1995). Study of the prenatal|toxicity of Protectol PP in Himalayan rabbits after oral|administration (gavage). BASF Project No. 40R0057/93055. 18|December 1995.
SafePharm communication to Karen Ruble, Eastman Chemical Company, December 4, 2003.
Salmonella typhimurium TA 1530 and his G-46, see p. 123
Carpenter CP, Smyth HF JR. 1946. Chemical burns of the rabbit cornea. Am J Opthalmol 29:1363-1372.
J. Am. Pharm. Assoc. Sci. Ed, vol 45, pg 669, 1956
BASF AG (2007). Evaluation of physical and chemical|properties according to Directive 67/548/EC Annex V. BASF|AG, GCT/S-L511, Ludwigshafen/Rhein, Germany, Study Code|SIK-Nr. 07/1018, 16 May 2007 (unpublished).
Melting point/freezing point, IUC4#0/Ch.2.1
Gersich, F.M. and Hopkins, D. L., Env. Tox. Chem. 5, 443-447|(1986)
Method: other: acute toxicity test according to Japanese Industrial Standard JIS K 0102-1986-71
Spivack, J.L., E.R. Pohl, and P. Kochs (1997)|Organoalkoxysilanes,|organosilanols, and organosiloxanols, in G. Chandra (ed.),|The Handbook of Environmental Chemistry, Vol. 3, Part H,|Organosilicon Materials. Springer-Verlag, Berlin, p 105.
Velsicol Chem Corp (1978) Benzotrichloride acute oral|toxicity (LD50) study in mice. Report No. 163-659 dated|November 20, 1978 with cover letter dated 7/27/82. FYI|Submission FYI-OTS-1180-0107. Washington, DC: Office of|Toxic Substances, U.S. Environmental Protection Agency
Koppers Company (1981) Fish Bioassay for resorcinol.
CIBA-GEIGY, Ltd. 1984. IN Hess R. and H. Schweinfurth. Ciba-Geigy, Ltd./Schering AG. Safety Evaluation of Octyltin Stabilizers. 08.06.1989.
Hoechst AG (1993) Material Safety Data Sheet p-Nitrotoluol|TTR (1993-04-20)
Solvay and Cie, unpublished, File no. 372 (1991).
US-EPA, GEMS (1986). Graphical Exposure Modeling System.|Fate of atmospheric pollutants (FAP) data base. Office of|Toxic Substances. Cited in: Howard PH (1989) Handbook of|Environmental Fate and Exposure Data. Vol. 1 Large|Production and Priority Pollutants, 73-77. Lewis Publ.|Chel-sea.
Short-term toxicity to fish, IUC4#44/Ch.4.1
Dow Corning Corporation (1982) Dow Corning Corporation|Internal Report No. 1982-I0005-0966
Human lymphocytes with and without metabolic activation
Method: other: Directive 92/69/ECC, part A.2 and A.4
MOE, Japan (1998): Ministry of the Environment, unpublished data
Du Pont, Haskell Laboratory, 1967, Report No. H4724
Schnell et al. (1989) Arch. Microbiol. 152:556-563.
Method: F26-25:Turbidity test (measurement of absorbance at 500 nm)
Biodegradation in water: screening tests, IUC4#21/Ch.3.5
Short-term toxicity to fish, IUC4#180/Ch.4.1
Muther, T.F.: Teratology 37, 239-247 (1988);|cited in: RIFM database, location no. 10221
Method: other: according to Knasmueller S. and Mohn G.R.: Chem. Biol. Interact., 58, 109-116 (1986)
Method: other: Gaseous methyl bromide in air-tight bottles. Autoradiography
Mercier, O. (1993). Hazleton France. Test to Evaluate the|Acute Ocular Irritation and Reversibility in the Rabbit. |Hazleton, France. (Hazleton Report No. 51792). 29 January|1993.Mercier, O. (1992) Test to Evaluate the Acute Ocular|Irritation|and Reversibility in the Rabbit. Hazleton, France. |(Hazleton Report No. 51792). 29 January 1993.
Nishimura, H. and Nakai, K.: Proc. Soc. Exp. Biol. Med. 104,||140-142 (1960);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
ABC Laboratories, Inc., Early Life-Stage Toxicity of Tributyl Phosphate to Rainbow Trout (Oncorhynchus mykiss) in a Flow-Through System, Project No. 38550, December 19, 1991 (at the request of the Synthetic Organic Chemical Manufacturers Association)
Williams, G.M. et al.: Mutat. Res. 221, 263-286 (1989), No information
Genetic toxicity in vitro, IUC4#176/Ch.5.5
Rannug A, Rannung U, Ramel C (1984) Genotoxic effects of|additives in synthetic elastomers with special consideration|to the mechanism of action of thiurames and|dithiocarbamates. Prog Clin Biol Res 141: 407-419
BASF AG, Abteilung Toxikologie; unveroeffentlichte|Untersuchung (X/26), 08.11.1960
Repeated dose toxicity: oral, IUC4#18/Ch.5.4
Heisler E and Dickhaus S (1993). Pruefung auf lokale|Vertraeglichkeit von Betolin K35 am Kaninchenauge. Pharmatox|Beratung und Forschung GmbH, Report no. 3-61-93.
Method: other: (calculated) MPBPWIN (v1.31) Program; Adapted Joback Method
Koopman, T.S.M. and Pot, T.E. (1986) Primary irritation|study of calcium chloride dihydrate to the skin of the male|rabbit. Duphar Report No. 56645/29/86.
McKinnon,M.B., Kaiser,K.L.E., Chemosphere 27, 1159-1169,|1993, No information
Subchronic inhalation toxicity - 90-day study with HCFC-124|in mice, E.I. du Pont de Nemours and Co., Haskell Laboratory|for Toxicology and Industrial Medicine, USA, Report No|695-91, 1991||Malley, L.A, Carakostas, M., Elliott, G.S., Alvarez, L.,|Schroeder, R.E., Frame, S.R., Van Pelt, C. Tromchimowicz,|H.J. and Rusch, G.M. Subchronic toxicity and teratogenicity|of 2-Chloro-1,2,2,2-tetrafluoroethane (HCFC-124), Fundam.|Appl. Toxicol., vol 32, 11-22, 1996
Method: other: Japan Industrial Standards, 1971
Romanova, N.B. and Rapoport, I.A.: Teor. Khim. Mutage-|neza, Mater. Vses. Soveshch. 4th; pp. 7-10 (1971):|cited in BUA-Stoffbericht 2, o-Chlornitrobenzol (Okto-|ber 1985), herausgegeben vom Beratergremium fuer um-|weltrelevante Altstoffe (BUA) der Gesellschaft Deutscher|Chemiker
Standard plate test; S. thyphimurium TA1535, TA100, TA1537, TA98; w/wo metabolic activation.
CIT (2003) Report number 24181. Determination of the abiotic|degradation (hydrolysis as a function of pH) of EHTG.
Budavari, S. et al. (1989): The Merck Index, 11th ed., Merck|& Co., Inc., Rahway, N.J.
EPA (2008). BCFWIN v2.17. Estimation Programs Interface for Microsoft Windows (EPI Suite version 3.20, U.S. Environmental Protection Agency, Office of Pollution Prevention and Toxics, Washington, D.C.)
Bayer AG (1989). Department of Toxicology. Calcium Formate.|Salmonella/microsome test to evaluate for point mutagenic|effects. Report No. 17696, dated April 25, 1989.
Toxicity to aquatic algae and cyanobacteria, IUC4#13/Ch.4.3
Marhold, J. (1986) "Prehled Prumyslove Toxikologie;|Organicke Latky,", Prague, Czechoslovakia Avicenum, p.1220
Method: other: 4 dose groups: 126 mg/kg (1 male), 200 mg/kg (2 males and 3 females), 316 mg/kg (1 female), 501 mg/kg (1 male); 24-h exposure; TS undiluted; post application observation period: 14 days, record of signs of intox., gross autopsy
Bayer Industrial Services (2003) Report on|N-(1,3-Dimethylbutyl)-N´-phenyl-1,4-phenylenediamine (6PPD).|Investigation on stability in aqueous test solutions|(unpublished)
Hirano, K. et al. (1978): Mutat. Res. 53, 200
Genetic toxicity in vitro, IUC4#260/Ch.5.5
Guseinov V.G. et al, 1981, Vopr. Okhrany Truda i Sostoyanic|Zdorov'ya Rabotayushch. S., P.144-52.
Method: other: acute study by inhalation with a dynamic method in 800 l chambers
BUA (2006). Registry database search performed 31.03.2006.
Method: other: calculation with Advanced Chemistry Development (ACD/Labs) Software V8.14 ((C) 1994-2006 ACD/Labs)
Method: other: Microtox toxicity analyzer
Ciba-Geigy Ltd., Reproduction study - TK 10044, mouse, Seg.|II, No. of experiment 327533, 28.8.1975.
Genetic toxicity in vitro, IUC4#116/Ch.5.5
Salmonella typhimurium strains TA98, TA100, TA1535, TA1537, Escherichia coli strain WP2uvrA
CIBA-GEIGY Ltd. 1993. Report on the growth inhibition test of Irgastab T 22 M to Green Algae (Scenedesmus subspicatus). Test No.: 928292. Basle, Switzerland. 26/04/93.
S. typhimurium TA 98, TA 98NR (nitroreductase deficient strain) and TA 98/1,8-DNP6 (esterifying enzyme-deficient strain)
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
BASF AG (1983). Department of Toxicology, unpublished data, study No. 83/112, 31 Aug 1983
Method: other: Stat. Fischtest Merkblatt 33, 2. Auflage, Biologische Bundesanstalt fuer Land- und Forstwirtschaft: "Unterlagen zur Toxikologie eines Pflanzenbehandlungsmittels im Rahmen des Zulassungsverfahrens", Absatz D-2.4: Auswirk. auf Fis
Mann K and Florence M (1987). Toxicity to oil shale|waste waters to marine algae. Fuel 66, 404-407.
Ma, T.H. et al.: Environ. Mutagen. 8, 49 (1986); abstract|no. 130, No information
RCC NOTOX, Primary skin irritation/corrosion study with|natrium benzoate in rabbits (study no. 014658). RCC NOTOX|B.V., 's-Hertogenbosch
Mabey W and Mill T (1978). Critical review of hydrolysis of|organic compounds in water under environmental conditions.|J. Phys. Chem. 7, 383-415
Chemfinder Internet Database (2005). Data sheet for|dicyclohexylamine. http://chemfinder.cambridgesoft.com.
Appearance/physical state/colour, IUC4#20/Ch.1.1.1
Appearance/physical state/colour, IUC4#10/Ch.1.1.1
Smyth H. et al., The single dose toxicity of some glycols|and derivatives, J Ind Hyg Toxicol 23(6):259-268, 1941 (25)
Salmonella typhimurium strains TA1535, TA1537, TA98, TA100, TA102; Escherichia coli WP2 uvrA.
Method: other: 5 rats/sex/dose group, 1 dose only as 30 % emulsion covered by aluminium foil fixed by broad stripes of adhesive plaster to back and belly for a 24 hour-exposure period: cleaning with soap and water, observation period: 1 week
Mirsalis JC and Butterworth B (1981). Induction of DNA|repair in hepatocytes from rats treated in vivo with|dinitrotoluene. Environ Mol Mutagen 3, 316.
Pfeifle V (1999) TINOPAL DMS pur extra: Acute toxicity od|TINOPAL DMS pur extra to the earthworm. Solvias AG, CH-4002|Basel (Switzerland)
Toxicity to soil macroorganisms except arthropods, IUC4#11/Ch.4.6.3
McLeese DW, Zitko V, Peterson MR (1979) Structure-Lethality Relationships for Phenols, Anilines and Other Aromatic Compounds in Shrimp and Clams. Chemosphere: chemistry, biology and toxicology as related to environmental problems, 8(2):53-57 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
CIBA-GEIGY, Ltd. 1986. Final Report. TK 11638/1. Skin Sensitization Test in the Guinea Pig Modified Maximization Test. GU Project No.: 861016. 09.12.1986.
Portmann JE (1972). Results of Acute Toxicity Tests with|Marine Organisms, Using a Standard Method, In: M.Ruivo|(Ed.), Marine Pollution and Sea Life, FAO, Rome, Italy;|Fishing News (Books) Ltd., London, England, 212-217
Quemeneur F, Bariou B and Kerfanto M (1971). Etude cinetique|de l'hydrolyse des alpha, alpha-dichloro et des alpha,alpha,|alpha-trichloro toluenes para-substitues, en milieu|eau-acetone a 50 %. C. R. Acad. Sc. Paris, 272, Serie C,|497-499.
Subchronic inhalation toxicity - Four-week study with|HCFC-124 (in rats), E.I. du Pont de Nemours and Co., Haskell|Laboratory for Toxicology and Industrial Medicine, USA, HLR|Report No 257-90, 1990
BASF AG, Department Toxicology, unpublished data on the|acute toxicity of Glyezin A to the Golden Orfe (Leuciscus|Idus L.), Project No.: 10F0411/875202, 10.Dec.1987
Adams, D.O. et al.: Toxicol. Appl. Pharmacol. 88, 165-174|(1987), No information
Bayer AG (1959) Unpublished short report, No. 2104-5
Method: other: according to Schmid, W. in: Hollaender, A. (ed.): Chemical Mutagens, Vol. 4, Plenum, New York; pp. 31-53
Genetic toxicity in vivo, IUC4#55/Ch.5.6
Ballantyne B, et al. (1989) Human Toxicol 8: 229 - 235
Kawalek JC, Hallmark RK, Andrews AW (1983) Effect of|Lithocholic acid on the mutagenicity of some substituted|aromatic amines. J Natl Cancer Inst 71: 293-298
Ministry of the Environment (MOE), Japan (1998), conducted|by Mitsubishi Chemical Safety Institute Ltd., Japan
Salmonella typhimurium "common" strains (e.g. TA 98, TA 100, TA 1535, TA 1537 or TA 1538)
Genetic toxicity in vivo, IUC4#174/Ch.5.6
Hasegawa, R. Takahashi, M., Kokubo, T., Furukawa, F.,|Toyoda, K., Sato, H., Kurokawa, Y., and Hayashi, Y. (1986):|Carcinogenicity study of sodium hypochlorite in F344 rats.|Fd. Chem. Toxicol., 24, 1295-1302.
Vargova M., Wagnerova J., Liskova A., Jakubovsky J., Gajdova|M., Stolcova E., Kubova J., Tulinska J., and Stenclova R.|(1993). Subacute immunotoxicity study of formaldehyde in|male rats. Drug and Chemical Toxicology 16, 255-275, No information
Repeated dose toxicity: oral, IUC4#130/Ch.5.4
Zok, Gorge, Kalsch, Nagel (1991): The Science of the Total|Environment 109/110, 411-421
Method: other: OECD, 1984, Guidelines for Testing of Chemicals. OECD, Paris
Short-term toxicity to fish, IUC4#29/Ch.4.1
BASF (1985) Report on the study of Mucochlorsaeure (84/342,|343) in the Ames test. BASF AG, Department of Toxicology,|07.06.1985 (unpublished data)
Method: other: according to Ames B.N. et al.: Proc.Nat.Acad.Sci. USA, 70, 2281-2285 (1973) and Ames B.N. et al.: Mut.Res., 31, 347-364 (1975)
FMC Corporation, Sodium Persulfate: Skin Corrosion Study in|Rabbits, FMC study no.: I80-403 (1980).
BASF AG (1971). Department of Toxicology, acute dermal toxicity rat, unpublished study, Study No. XXI/183, 22 December 1971.
Method: other: acc. to Noakes, D.N. and Sanderson, D.M.: Brit. J. Ind. Med., 26, 59, 1969
Eilersen AM, Henze M, and Kløft L (1994). Effect of volatile|fatty acids and trimethylamine on nitrification in activated|sludge. Wat. Res. 28(6), 1329-1336.
MacKenzie, K. and M. Schoffman (1951) U.S. Patent|US2537073.
Sigma-Aldrich (2003) Statement provided by technical service|including excerpts of technical information system|(unpublished data)
Daubert, T.E. and Danner, R.P. (1989), cited in SRC PhysProp|Database, http://esc.syrres.com/interkow/webprop.exe, 27 May|2004
Roger et al.; Biochem. Pharmacol. 18, 373-392 (1969)
Developmental toxicity / teratogenicity, IUC4#50/Ch.5.8.2
Lysy HH, McCay JA, White KL, Munson AE (1988) Suppression of|humoral immunity by mono-nitrotoluenes (a structural|activity study). The Toxicologist 8: 322
Repeated dose toxicity: oral, IUC4#19/Ch.5.4
Springborn Laboratories, Inc.: Life Sciences Division,|SLS Study No. 3224.7, 25.04.1991
Salmomella typhimurium TA98, TA100, TA1535, TA1537.
Muermann P. 1990. Huls AG Bericht [Report] Nr. 1750. Prufung der akuten Hautreizwirkung von ethyldiglykolacetat [Test of acute skin irritation for ethyl diglykol acetate], dated May 23, 1990.
Hoechst AG (1994): Unveröffentlichte Untersuchung 93-0161-32
Salmonella typhimurium (no further information)
Okazaki S. et al., Bozo Research Center Inc., Japan (1996). Twenty-eight-day repeat dose oral toxicity test of N-(aminoethyl)ethanolamine in rats. |In: Ministry of Health and Welfare (ed.), Japan (1996) Toxicity Testing Reports of Environmental Chemicals, Vol. 4, 351-365.
Method: other: Guidelines for 28-Day Repeat Dose Toxicity Test of Chemicals (Japan)
Nomura, T.: Cancer Res. 43, 1342-1346 (1983); and |cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Schriftenreihe des Bundesministers fuer Jugend, Familie und|Gesundheit, Band 148, Formaldehyd, Verlag W. Kohlhammer,|Stuttgart-Berlin-Köln-Mainz, No information
Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, Escherichia coli WP2uvrA
Method: other: determination of vapour pressure comparable to OECD Guideline No. 104
DeFlora, S. et al.: Mutat. Res. 133, 161-198 (1984), No information
Genetic toxicity in vitro, IUC4#145/Ch.5.5
CSCL. Biodegradation and bioaccumulation data of existing|chemicals based on the CSCL (Chemical Substance Control Law)|Japan, Ed. Chemicals Inspection and Testing Institute,|October 1992.
Chemfinder Internet Database (2005). Data sheet for 1,4-dichloro-2-butene. http://chemfinder.cambridgesoft.com.
Schmid E (1991) FAT 65'023/N: Report on theb Determination|of the IC 50 of FAT 65'023/N. CIBA-GEIGY Ltd., CH-4002 Basel|(Switzerland)
Florin J, Rutberg L, Curvall M and Enzell CR (1980).|Screening of Tobacco Smoke Constituents for Mutagenicity|using the Ames' Test. Toxicology 18, 219-232.
Method: other: According to Ames et al., Mut. Res. 31(6), 347-364
Salmonella typhimurium TA 97, TA 98, TA 100
Measurement of dissociation constant, Krume Research|Laboratories, Japan, Test No., 80647, December 1991
Ellington J.J.(1989) Hydrolysis Rate Constants for Enhancing Property-Reactivity Relationships. USEPA/600/3-89/063 July 1989, NTIS PB89-220479, p.16
Method: other: estimation from the isomers
Honma M, Zhang LZ, Sakamoto H, Ozaki M, Takeshita K, Momose|M, Hayashi M and Sofuni T (1999b). The need for long-term|treatment in the mouse lymphoma assay. Mutagenesis 14,|23-29.
Method: other: Microwell method with long-term treatment
E.I. du Pont de Nemours and Company, unpubl. results,|Medical Res. Proj. 3872-001/HLR 294-90, 05 Oct. 1990
Method: other: segment of a reproduction toxicity study
Method: other (measured): vapour pressure balance
Mills EJ and Stack VT (1954). Purdue 8th Industrial Waste|Conference, Purdue University, Extension series 83, 492-517
ICI PLC, 1983, Toxicity to Brown Shrimp (Crangon crangon) of|"Choline Chloride" (75% aqueous solution), unpublished data,|report No BLS/B/0194, 10 June 1983
Bayer AG 2002, Calculation of log Pow with SRC-KOWWIN v.|1.66 (2000)
Method: other (calculated): SRC-KOWWIN v. 1.66
FMC Corporation, Acute and 28-day subacute toxicity of|ammonium persulfate, Study no. ICG/T-79-025, 1979.
Ishidate, M. Jr. & Odagiri, Y., Mutat. Res. 224, 357-359|(1989)
Method: other: Method in general accordance with OECD method 479; however testing only without metabolic activation
Pharmakon Research Int., Inc., Rat Hepatocyte Primary|Culture DNA Repair Test PH 311-UN-001-84 Flexzone 7F.|Unpublished study of Uniroyal Chemical Co., May 2, 1984
Method: other: CIBA-GEIGY Internal Method FC2.463 (1973)
Short-term toxicity to fish, IUC4#12/Ch.4.1
Kasai, H., Nishimura, S., Kurokawa, Y. and Hayashi, Y.|(1987): Oral administration of the renal carcinogen,|potassium bromate, specifically produces|8-hydroxydeoxyguanosine in rat target organ DNA.|Carcinogenesis 8, 1959-1961.
Hinton, M.J. and Eversole, A.G. in: Proceedings of the 10th|annual meeting of the world mariculture society, 554-560|(1979);|cited in: IPCS Environ. Health Crit. 89, (1989), No information
Method: other: Japanese Industry and Health Law Article 57-2 §1
Goldman, P., L.A. Wheeler, J.H. Carter, J.A. Ingelfinger, F.B. Soderberg. Properties of the Ames Salmonella mutants lodged in the gastrointestinal tract of gnotobiotic rats. Am. J. Clin. Nutr. 30, 1921-1926, 1977
Method: other: according to Nesslany and Marzin (1999) Mutagen 14: 403-410
Schulz and Schwanitz (1981) Teratology 24:48A.
Collins, T.F.X. et al.: Regul. Toxicol. Pharmacol. 1,|355-378 (1981);|and cited in: IARC Monographs on the Evaluation of|Carcinogenic Risk to Humans, Vol. 51, Lyon, France (1991);|pp. 291-390
Kinkel HJ, Holzman S (1973) Study of Long-term Percutaneous Toxicity and Carcinogenicity of Hair Dyes (Oxidizing Dyes) in Rats. Food and Cosmetics Toxicology 11:641-648 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc).
BASF AG, Department of Product Safety, Expert Judgement,|2006
Method: other: QSAR Estimation Method: BCFWIN v. 2.15 (2000)
Bioaccumulation: aquatic / sediment, IUC4#30/Ch.3.7
Method: other (calculated): Estimation using KOWWIN (ver. 1.66)
Eller K, Henkes E (2000). Amines, aliphatic. Ullmann´s|Encyclopedia of Industrial Chemistry. Electronic release.|Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Horowitz,A., Calvert,J.G., International Journal of Chemical|Kinetics, Vol.X, 805-819, 1978, No information
Method: other: OECD TG 105 (Flask method)
Method: other: Calculated by MPBPWIN v.1.41, 2000
Brooke, L.T., D.J. Call, D.L Geiger, and C.E. Northcott.|1984. Acute Toxicities of Organic Chemicals to Fathead|Minnows (Pimephales promelas), Vol. I. Center for Lake|Superior Environmental Studies, University of Wisconsin,|Superior, WI.
Method: other: Ames (modified according to Nohmi, et al. 1986. Toxicol. Forum. 9:189-198.)
Doolittle, D.J. et al.: Toxicol. Appl. Pharmacol. 79, 28-38|(1985), No information
Genetic toxicity in vitro, IUC4#171/Ch.5.5
Yasuda-Yasaki Y., Namike-Kanie S. and Hachisaku Y.|Inhibition of Germination of Bacillus Subtilis Spores by|Alcohols. Spores 7:13-16. 1976.
Dearman, R.J., Mitchel, J.A., Basketter, D.A., and Kimber,|I. 1992. Differential ability of occupational chemical|contact and respiratory allergens to cause immediate and|delayed dermal hypersensitivity reactions in mice. Int.|Arch. Allergy Immmunol. 97: 315-321.
Method: other: comparable with OECD Guide-line 481
Princeton Aqua Science. 1982. 96-hour static bioassay with tetrabutyltin in fathead minnows. July 1982.
Method: other: USEPA and NJ Dept. of Environmental Protection (NJDEP)
Environmental Agency, Japan (1999d) Unpublished testing|report on acute toxicity of o-chlorobenzyl chloride to|Oryzias latipes, Test No.10044, conducted by Japan Food|Research Laboratories.
ATOFINA Chemicals, Inc. 2000. Material Safety Data Sheet. TOT, Commercial Grade. Product Code RKW04. Revision 2. Date Issued: 17 Jun 2000.
Genetic toxicity in vitro, IUC4#280/Ch.5.5
Mori, Y. et al. (1980) Carcinogenesis, 1, 121-127.
ChemACX.com. 2001. http://www.chemacx.com/chemacx/default.asp?formgroup=basenp_fm_group&dbnam e=chemacx&dataaction=query_string&field_type=TX&field_criteria=IN&full_fie ld_name=Substance.ACX_ID&field_ale=X1027680-3 (accessed May 18, 2001).
Klecak, G., The Freund's complete adjuvant test and the Open|Epicutaneous Test, Curr. Probl. Derm., vol. 14, 152-171,|Karger, Basel, 1985
Method: other: Klecak et al., J. Soc. Cosmet. Chem., 28, 53-64, 1977
Ulrich, J.L., Shternov, V.A. (1929). The comparative action|of hypertonic solutions of the chlorates and chlorides of|potassium, sodium, calcium and magnesium. Journ. Pharm. And|Exper. Therap. 35:11-15.
Bayer Industry Services (2004d). Acute Daphnia Toxicity of 1,4-Dichloro-2-butene. Unpublished Report, No. 1326 A/04 D.
Method: other: Directive 92/69/EEC, C.2 in most parts equivalent to OECD TG 202
CIBA-GEIGY, Ltd. 1984. Mouse Lymphoma Mutagenicity Test. Test No. 830525. 28.06.1984.
Placke M, Griffis L, Bird M, Bus J, Persing R and Cox L Jr|(1996). Chronic inhalation oncogenicity study of isoprene in|B6C3F1 mice, Toxicology, Vol. 113, pp. 253-262.
HOECHST AG, Abt. UWS, Abwasserforschung-Biologie,REPRINT OF|AN EXISTING TEST REPORT from 1978,|(27.02.92)
Method: other: Gas Production Test (Fermentation Tube Test), not standardized
Chrysostom MM (1936) The influence of several benzene derivatives on the roots of Lupinus albus. American Journal of Botany 23:461-471 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Toxicity to terrestrial plants, IUC4#12/Ch.4.6.2
Kromann A, Christensen TH (1998) Degradability of organic|chemicals in a landfill environment studied by in situ and|laboratory leachate reactors. Waste Manage Res 16: 437 - 445
Van Leeuven CJ, Grootelaar EMM, Niebeek G (1990) Fish mbryos as teratogenicity screens: a comparison of embryotoxicity between fish and birds. Ecotoxicology and Environmental Safety 20:42-52.
Method: other: OECD Guide-line draft "Early Life Stage Test (ELS-Test)"
Hansch, C. and A.J. Leo. 1985. Medchem Project. Pomona|College, Issue 26, Claremont, CA. As cited in Assessment|Technologies, Inc. Butyl Acetate - An Environmental Fate|and Aquatic Effects Assessment. Draft Report May 26, 1998.
Thatcher et al. (1976) Bull Environ Contam Toxicol, 15,|40-48
Mirsalis JC, Tyson CK, Steinmetz KL, Loh EK, Hamilton CM,|Bakke JP, Spalding JW (1989) Measurement of unscheduled DNA|synthesis and s-phase synthesis in rodent hepatocytes|following in vivo treatment: testing of 24 compounds.|Environ Molec Mutagen 14: 155-164
Migchielsen, M.H.J. and H.P.M. de Haan. 2004. Tetraoctylstannane [Tetraoctyltin, CAS No. 3590-84-9]: 96-hour acute toxicity study in zebra-fish (semi-static). NOTOX Project 375007. TNO Study number 5316/01. November 30, 2004.
Mitsubishi Gas Chemical Co., unpublished Report: MT04-01, 1992, Reverse Mutation Test of m-Toluic Acid
Budavari S (1996). The Merck Index - An Encyclopedia of|Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ:|Merck and Co., Inc., 407.
Solubility in organic solvents / fat solubility, IUC4#300/Ch.2.6.1
CIBA-GEIGY, Ltd. 1980. Report on Acute Oral LD50 in the Rat of TK 10701. Project No. 801408. 20.10.1980.
Maibach, H.: Final Report: "Reliable animal test for|predicting skin sensitizers", Contract CPSC-C77-0087,|Consumer product safety commission, Washington, DC (1978), No information
Bayer AG (1984) Inhibition of sludge respiration,|unpublished study 1984-07-12
Budavari S (2001). The Merck Index, Monograph 3122:|Dicyclohexylamine. 13th edition, 2001 electronic release.|Whitehouse Station, New Jersey, USA.
H. C. Starck (2003). Advanced Ceramic Powders and Ampersint|Powders for P/M. WWW.hcstarck.com.
Ihara Chemical Industry Co., Ltd. (1992) Unpublished testing|report titled "Dermal corrosion study of 2-chlorobenzyl|chloride in rabbits.", Study No. 1L335-E, conducted by|Mitsubishi-Kasei Institute of Toxicological and|Environmental Sciences.
SKW Trostberg AG: Safety Data Sheet; revised Jan.21.1999
Gibson HW (1969). The chemistry of formic acid and its|simple derivatives. Chemical Reviews 69, 673-692.
RCC-NOTOX (1988b): Determination of the partition coefficient of Benzoguanamine, Study Ref. No. 0913/C 604, September 1988
Long-term toxicity to fish, IUC4#20/Ch.4.5.1
Kligermann, A.D. et al.: Toxicol. Lett. 21, 241-246 (1984), No information
Method: other: in vivo DNA damage - mammals (somatic cells)
Genetic toxicity in vivo, IUC4#76/Ch.5.6
Method: other: Behavioral teratogenicity study
Bowman J. Acute Flow-Through Toxicity of n-Butyl Acrylate|to Rainbow Trout (Salmo gairdneri). Testing Facility: |Analytical Bio-Chemistry Laboratories, Inc., 7200 East ABC|Lane, Columbia, Missouri. Sponsor: Basic Acrylic Monomer|Manufactures, 1330 Connecticut Ave, Washington DC. Project|Identification No.37339. Study Date: 1990.
Hyttinen JMT, Niittykoski M, Jansson K (1995) Lack of|uniformity in the mutational spectra of|chlorohydroxyfuranones in Salmonella typhimurium strain|TA100. Mutagenesis 10: 321-323
Redmond MS, Crocker PA, McKenna KM, Petrocelli EA, Scott KJ|and Demas CR (1996). Sediment toxicity testing with the|amphipod Ampelisca abdita in Calcasieu Estuary, Lousiana.|Arch. Environ. Contam. Toxicol. 30, 53-61.
McCoy E.C. et al (1978), Mutation Research, 57, 11-15.
Collander R (1951). The Partition of Organic Compounds|Between Higher Alcohols and Water. Acta Chemica Scandinavica|5, 774-780.
Mose, V.T. (1974), Allergiske reaktioner mod tandpasta,|Tandlaegebladet 78, 325-328
BASF AG, Department of Ecology, unpublished calculation, , Mackay Level I, V 2.11 Model, AOP V 1.87, Hydrowin V 1.67, KOWWIN V 1.60, Dec. 1998
Rosin (1984) Mutation Research 153:109-113.
Paschin et al. (1986): Food Chem. Toxicol. 24, 881-883
Method: other: Schmid (1973) Agens & Actions 3: 77
Genetic toxicity in vivo, IUC4#30/Ch.5.6
Heitmuller PT, Hollister TA and Parrish PR (1981). Acute|toxicity of 54 industrial chemicals to sheepshead minnow|(Cyprinodon variegatus), Bull. Environ. Contam. Toxicol. 27,|596-604.
Method: other: Methods for Acute Toxicity Tests with Fish, Macroinvertebrates, and Amphibians, US EPA
Norris, J.M., Olson, K.J., (1968). Toxicological properties|and industrial handling hazards of Dowanol PPh|(1-phenoxy-2-propanol), Toxicology research laboratory|report. Unpublished data, the Dow Chemical Company, 1986.
Method: other: acute toxicity of benzotrichloride after single oral treatment og female Wistar rats
Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B,|Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S, Rimpo J,|Margolin BH, Resnick MA, Anderson B, Zeiger E (1987)|Chromosome aberrations and sister chromatid exchanges in|chinese hamster ovary cells: evaluation of 108 chemicals.|Environ Mol Mutagen 10 [Suppl.10]: 1-175 (1987)
Chemicals Evaluation and Research Institute (CERI), Japan.|(2003). Calculation of water-soil partition coefficient with|SRC-EPIWIN v.3.10.
Smith, P.K. and W.E Hambourger. The ratio of the toxicity of acetanilide to its antipyretic activity in rats. J. Pharm. Exp. Ther. 54, 159-161, 1935
Method: other: test procedure comparable to OECD guideline 405, evaluation according to Draize
Greenwood, N.N. and A. Earnshaw. 1997. Chemistry of the Elements. Oxford: Butterworth Heinemann.
Saeger, V.W. et al., Environ. Sci. Technol. 13 (7), 840-844|(1979)
Ciba-Geigy Ltd. 1976. Acute Inhalation Toxicity in the Rat of TK 11339. Project No.: Siss 5354. 14.5.1976.
Lebertz, H. 1991a. Study on the 'ready biodegradability(modified Sturm Test) of trimellitic anhydride. Final|Report. Battelle Europe Study No.: BE-EA-128-91-01-STT-01.
Cassee, F.R. et al.: Arch. Toxicol. 70, 329-337 (1996), No information
Haarmann & Reimer GmbH (1989), Assessment of the eye|irritant|effect of HR 89/620006 in rabbits, Scantox - biological|laboratory ltd lab no. 11872, 16.08.1989
Panigrahi, G.B. and Rao, A.R.: Mutat. Res. 122, 347-353|(1983)
Genetic toxicity in vivo, IUC4#17/Ch.5.6
Giftinformationszentrum (2006). Ameisensäure.|Giftinformationszentrum Universität Mainz.|www.giftinfo.uni-mainz.de
Fujita H. & Sasaki M. (1986). Ann. Rep. Tokyo Metr. Res. Lab. P.H. 37,477
Izmerov N.F. et al.: Toxicom. Param. Ind. Toxic Chem. Single|Exp. 28, Moskau (1982): zit. nach RTECS, update 8909
Neumeier W, Haas R and v.Loew E (1989). Mikrobieller Abbau|von Nitroaromaten aus einer ehemaligen|Sprengstoffproduktion. Forum Staedte Hygiene 40, 32-37.
Biodegradation in water: screening tests, IUC4#55/Ch.3.5
Kronenberg S, Menweg M (1991). FAT 65'023/N: Report on the|Determination of the BOD5. CIBA-GEIGY Ltd., CH-4002 Basel|(Switzerland), Report No. G 093 01.
Biodegradation in water: screening tests, IUC4#11/Ch.3.6
Melting point/freezing point, IUC4#60/Ch.2.1
CITI, Japan: Report No. K-131, Chemicals Inspection and|Testing Institute, (1976) unpublished data
Method: other: equivalent of OECD TG 302 C
Le J., Jung R., Kramer M. (1985) Effects of using fractions|from different mammals, including man, on results of|mutagenicity assays in salmonella typhimurium: Fd. Chem.|Toxic. 23(7), 695-700
Method: other: accpording to Ames (1975) and Maronet al.(1983)
IITRI 1985. Two-Week Inhalation Toxicity Study of|Trimellitic Anhydride in Rats. Final Report. IITRI Project|No. L8100, Study No. 674, Test Article No., 128C
Method: other: calculated by BCFWIN v2.14
Salmonella typhimurium, strains TA 1535, TA 1537, TA 1538, TA 98, TA 100
Corbett, M. D. and Corbett, B. R., Metabolism of|4-Chloronitrobenzene by the Yeast Rhodosporidium sp.,|Applied and Environmental Microbiology 41, 942-949 (1981)
Freese, E. et al., Teratology 20, 413 (1979)
Merck Schuchardt. Hohenbrunn, Germany. Safety Data Sheet. Isopropyl Acetate for Synthesis. 04.2000. The Merck Chemical Database-online. http://www.merck.de (accessed October 17, 2000)
Arnold D. Mutagenic study with FA-15 in Albino mice. Report|IBT No. E9647, August 19, 1971. Industrial Bio-Test|Laboratories Inc., Northbrook, IL, USA.
Bringmann G and Kuehn R (1976). Vergleichende Befunde der|Schadwirkung wassergefaehrdender Stoffe gegen Bakterien|(Pseudomonas putida) und Blaualgen (Microcystis aeruginosa).|GWF-Wasser/Abwasser 117, 410-413.
Method: other: cell multiplication inhibition test according to Bringmann and Kuehn
Safety Data Sheet, Dow Europe S.A., October 1993.
Arnett EM, Harrelson Ja Jr. (1987). Ion Pairing and|Reactivity of the Enolate Anions. VIII Enolisation,|Hydrogen-Bonding and the Correlation of Pka's with Rates of|Alkylation and Redox Potentials of some ß-Di and|Tri-Carbonyl Compounds in Dimethylsulfoxide. Gazz. Chem.|Ital. 117, 237-243.
Epona Associates, LLC. 2006. IUCLID Data Set: Isooctyl Mercaptoacetate [CAS No. 25103-09-7]. 30.05.2006.
Atofina (2001) 11-aminoundecanoic acid, 4-week toxicity|study by oral route (dietary admixture) in rats. CIT report|no. 20479 TSR, 22 October 2001.
BASF AG (1979) Report of the acute toxicity - Leuciscus|idus L. Department of Toxicology, unpublished report No.|78/594, March 29, 1979
Method: other: following German Industrial Standard DIN 38412, Part 15
Lakhanisky, T. & Hendrickx, B., Prog. Mutat. Res. 5,|367-370 (1985)
Lyondell Chemical Company (2005) A Prenatal Developmental|Toxicity Study of Allyl Alcohol in Rats. WIL Research|Laboratories, LLC. Study No. WIL-14038
Single oral dose toxicity was estimated by the gastric intubation of groups of 10 to 35 non-fasted rabbits. The rabbits were 1.5 – 2.5 kilograms gained weight during a two-week pre-dosing observation period. Animals were observed for 24 hours following
Ishizaki, M. & Ueno, S., J. Food Hyg. Soc. Japan 30,|447-451 (1989)
Kuehn, R. et al., Results of the harmful effects of water|pollutants to Daphnia magna in the 21 day reproduction test,|Water Research 23 (4), 501-510 (1989)
lysogenic strains of E. coli carried lambda prophage
Method: other: proposal of the Federal Environment Agency: Letale Wirkung beim Zebrabärbling Brachydanio rerio (LC0, LC50, LC100; 48-96h) (1982)
DuPont, Haskell Laboratory (1993) Report No. 777-93, unpublished data.
Perstorp (2007). Info on sodium formate and potassium formate. Personal communication to ACC, unpublished, 03 Jun 2007.
Method: other (calculated): with SRC-KOWWIN v.1.66, 2000
Wiberg, N. (1985). In Lehrbuch der Anorganischen Chemie.|A.F. Holleman, E. Wiberg (eds). Walter de Gruyter, Berlin -|New York.
Rauscher leukemia virus (RLV) infected Fischer rat-embryo (RIFRE) cells
Chemical Inspection and Testing Institute of Japan (1992) Biodegradation and bioaccumulation data of existing chemicals based on the CSCL Japan, MITI, p 2-26
Huntingdon Research Centre Ltd. (1988) Irritant effects on|the rabbit eye of Isobutyltriethoxysilane [Dynasylan IBTEO].|Report 87426D/DNN 14/SE. Degussa-Huls AG-Nr.: 88-0347-FKT |August 31, 1988
Saccharomyces cerevisiae PG-148, PG-154, PG-155, PG-166
Method: other: 1 dose level; 14 days observation period
Jenner, P.M., Hagan, E.C., Taylor, J.M., Cook, E.L., and|Fitzhugh, O.G. 1964. Food flavourings and compounds of|related structure. 1. Acute oral toxicity. Fd. Cosmet.|Toxicol. 2: 327-343.
Method: other: : FDA method. LD50's were computed by the method of Litchfield & Wilcoxon.
BASF (1981) Zahn-Wellens test (mucochloric acid; adapted|inoculum). BASF AG, Dpt. of Ecology (unpublished raw data of|11.06.1981 + unpublished reprint of 05.07.2002)
Mathews et al. (1975) J Tenn Acad Sci, 50, 62
Short-term toxicity to aquatic invertebrates, IUC4#36/Ch.4.2
Dryden, L.P. and Hartman, A.M. (1971) Effect of vitamin B12|on the metabolism in the rat of volatile fatty acids. J.|Nutr. 101:589-592. Cited in BIBRA (1993).
Miles, Inc. (1988) Verteiler H: Investigations of the acute|oral toxicity to male and female Wistar rats, with cover|letter dated 04/27/94 (in German). (Contractor: Bayer AG)|Microfiche OTS0558027. Document No. 86940001764. Cited in|NISC and BiblioLine (2009) BiblioLine - www.nisc.com.
Thurston, R.V. and Russo, R. C., Trans. Am. Fish.|Soc.,112(5), 696-704(1983)
YALKOWSKY,S.H.; DANNENFELSER,R.M.; AQUASOL DATABASE OF|AQUEOUS SOLUBILITY . VERSION 5.; COLLEGE OF PHARMACY,|UNIVERSITY OF ARIZONA - TUCSON,AZ. PC VERSION.; 1992
Biodynamic Inc., Project No. 89-3534, January 24 (1991)|(at the request of the Synthetic Organic Chemical Manu-|facturers Association Inc.)
BASF (1981) Zahn-Wellens test (mucochloric acid). BASF AG,|Dpt. of Ecology, 14.04.1981 (unpublished data; Reprint|05.07.2002)
Salmonella typhimurium TA98, TA100, TA 1535, TA1537, TA1538
Carney E.W. , Crissman J.W. , Liberacki., A.B. Clements, C.M. , Breslin and W.J. , "Two-Generation Inhalation Reproduction Study with Propylene Glycol Monomethyl Ether in Sprague-Dawley Rats," Toxicol.Sci. 50, 249-258 (1999)
OECD Guideline 416 (Two-Generation Reproduction Toxicity Study)
BASF AG (2004). Department of Product Safety, unpublished|data assessment, BCFWIN (v2.14), 08 Oct 2004.
Adema, D.M.M. (1988) Aminoethylpiperazine: static acute|toxicity evaluation with Salmo gairdneri. Unpublished Dow|Chemical Company report.
DuPont (1974a). Acute Inhalation Toxicity. Haskell Laboratory, Report No. 88-74 from February 20, 1974 (NTIS OTS 571232).
Aldrich Chem Co, (1994) Catalog/Handbook of Fine Chemicals 1994-95, Milwaukee, WI, pp 466. Aldrich Chemical Co., Inc. (1999) MSDS.
Fahrig R. and A. Neuhaeuser-Klaus: Mut. Res. 224, 377-378,|(1989)
Method: other: according to Fahrig 1975, Mol. Gen. Genet. 138, 309
Single oral dose toxicity was estimated by the gastric intubation of groups of five non-fasted Carworth-Wistar male rats. The rats were 90 – 120 grams and 4-5 weeks of age. Animals were observed for 14 days following dosing. The dosages were arranged
Wakita K, Yoshimoto M, Miyamoto S, Watanabe H (1986) A|Method for Calculation of the Aqueous Solubility of Organic|Compounds by Using New Fragment Solubility Constants. Chem|Pharm Bull 34: 4663 - 4681
Method: other: calculated with fragment solubility constants
The Merck Index (2000) 12th edition Vs 12.3
Bacchus, H. (1951). Decrease of cardiac mass following|excess dietary potassium chlroide in the rat. Amer. J. Phys.|166:273-276.
de Vries, H., A.H. Penninks, N.J. Snoeij, and W. Seinen. 1991. Comparative toxicity of organotin compounds to rainbow trout (Oncorhynchus mykiss) yolk sac fry. The Science of the Total Environmental. 103:229-243.
Method: other: comparable to OECD Guideline 201 (Algae, Growth inhibition test, 1984)
Monsanto Study No. Y-73-222 as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Salmonella typhimurium TA98, TA1537, TA1538, TA100; Escherichia coli WP2uvrA
Heisler E and Dickhaus S (1993). Pruefung von Betolin K35|als|25%ige Verduennung beim Kaninchen nach Draize auf primaere|Hautreizwirkung. Pharmatox Beratung und Forschung GmbH,|Report no. 3-60-93.
Method: other: calculated from Kow (WSKOW v1.41)
2-ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate (IUC4 DSN 26)
Zahn,R., Wellens,H., Zeitschrift fuer Wasser- und Abwasser-|Forschung, 13(1), 1-7, (1980)
Kawasaki M (1980). Experiences with the test scheme under|the Chemical Control Law of Japan: An approach to|structure-activity correlation. Ecotox. Environ. Safety 4,|444-454.
Method: other: Japanese Guideline by MITI (1974). Comparable to OECD TG 301 C, Modified MITI Test I
Method: other: Inhibition of glucose degradation: investigation not performed to any guideline.
Toxicity to microorganisms, IUC4#18/Ch.4.4
Neely WB (1980) Chemicals in the Environment. Distribution,|Transport, Fate Analysis, Marcel Dekker, New York, Basel.
Appel M, Raabe T, and Lingens F (1984). Degradation of|o-toluidine by Rhodococcus rhodochrous. FEMS Microbiol.|Lett. 24, 123-126.
CIBA-GEIGY, Ltd. 1983. Autoradiographic DNA Repair Test on Human Fibroblasts. Test No. 830522. 28.11.1983.
Method: other: San, R.H.C. and H.F. Stich
Hoechst AG, unveroeffentlichte Untersuchung 87.0495,(1987)|zitiert im Hoechst-GDS vom 14.04.(1994)
Ciba-Geigy Ltd., Effect of TK 10044 on reproductive|functions of two generations in the rat, Project No CBG|337/831043, 3.1.1986.
Hoechst AG (1988) Nitro-o-dichlor-benzol asym. Prüfung auf|Augenreizung am Kaninchen (unpublished report no. 88.2125).|Hoechst AG, Frankfurt
Method: other: OECD Guide-line 405, see also freetext TC
Mittler, S. et al.: Mutat. Res. 4, 708-710 (1967);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Figge, K. and J. Koch. 1973. Migration of the Methyltin Stabilizer Advastab TM-181-FS from Rigid PVC in the Fat Simulant HB307. April 1973.
Hazleton Laboratories America, Inc. (1983) Acute Dermal|Toxicity Study in Rabbits. Methyl Mercaptopropionate. |Project No. 652-153.
Method: other: similar to OECD 402 and OPPTS 870.120
BASF (1988) Partition coefficient, report to J.Nr.124837/01.|BASF AG, Analytical Laboratory, 03.03.1988 (unpublished|data)
HRC (Huntingdon Research Centre, Deutschland) (1979a).|Isophoron - Prüfung der Hautverträglichkeit nach einmaliger|Applikation auf die intakte oder skarifizierte Haut beim|Kaninchen. Report No. 326a.
RTECS, update 9301 (through July 1993): Toxicol. Appl.|Pharmcol. 44, 1 (1978)
Salmonella typhimrium TA 98, TA 100, TA 1535, TA 1537, TA 1538
Deneer, J.W. et al., QSAR study of the toxicity of|nitrobenzene derivatives towards Daphnia magna, Chlorella|pyrenoidosa and Photobacterium phosphoreum, Aquatic|Toxicology, 15, 83-98 (1989)
Method: other: according to the Protocol of the Dutch Standards Organisation, NEN 6501 (1980)
BASF AG (2006). Department of Product Safety, data|assessment, EPIWIN (v3.12), 12 Sep 2006, unpublished.
Bioaccumulation: aquatic / sediment, IUC4#50/Ch.3.7
Kovalenko II (1973) Chemotoxische Wirkungen von|Nitrotoluolen in Abhänigkeit von der Isomerie und der Zahl|der Nitrogruppen. Farmakol Toksikol 8: 137-140; zitiert in|Chem Abstr 80: 116843h (1974)
Method: other: comparative toxicity and cancerogenicity,see also TC
McGregor DB (1981). Tier II mutagenic screening of 13 NIOSH|priority compounds; individual compound report:|N-methyl-dicyclohexylamine, Report No. 1190; Project No.|409959, Inveresk Research International Ltd., at the request|of the National Institute for Occupational Safety and Health|(NIOSH) Cincinnati/OH, PB83-126607
TSCATS: OTS 0510692, "Seven Day Skin Irritation Study in Rabbits", unpublished report (HAEL No. 86-0129 ACC. No. 900303), Eastman Kodak Co., (1986); cited in BG Chemie (ed.): 2-Methylpropanol-1, in: Toxikologische Bewertung Nr.96, Ausgabe 01/97, BG Chemie, Heidelberg, pp. 3-40, (1997) as cited in IUCLID.
Repeated dose toxicity: dermal, IUC4#110/Ch.5.4
Salmonella typhimurium TA98, TA100, TA1535, TA1537 and E. coli WP2uvrA/pKM101
Method: other: calculation: EPIWIN BCFWIN
US Department of Health and Human Services (2001) National|Toxicology Program, NTP Technical report on the toxicology|and carcinogenesis studies of p-Nitrotoluene in F344/N rats|and B6C3F1 mice. NTP technical report No. 498, NIH|Publication No. 01-4432
Method: other: : in accordance with OECD TG 453, see freetext Method
Sasaki S. (1978) The scientific aspects of the chemical|substance control law in Japan. In: Aquatic Pollutants:|Transformation and Biological effects Hutzinger O Von|Letoeld LH and Zoetman BCJ (EDS) Oxford Pergamon Press|283-98
Degussa AG, Assessment of the acute toxicity of ammonium|persulfate on the cell multiplication of a pure culture of|Pseudomonas putida bacteria. (acute bacteria cell|multiplication inhibition test), Study no. 88-0014-DGO,|1988.
Method: other: Umweltsbundesamt (UBA) Guidelines: Bewertung wassergefaehrdender Stoffe, III Bestimmung der akuten Bakterientoxizitaet, Ad-hoc-Arbeidsgruppe I (Obmann Dr. Niemitz), LTwS, Nr. September 1979.
ELF ATOCHEM (1994) ACIDE 3-MERCAPTOPROPIONIQUE,|DETERMINATION DE LA BIODEGRADABILITE FACILE, ESSAI DE|DISPARITION DU COD.CENTRE D'APPLICATION DE LEVALLOIS,RAPPORT|n° 3243/94/B, LE 21/11/94.
EU Method C.4-A (Determination of the "Ready" Biodegradability - Dissolved Organic Carbon (DOC) Die-Away Test)
Bunce NJ, Merrick R, Corke CT (1983) Reductive|Transformations of Nitrate with 3,4-Dichloroaniline and|Related Compounds by Escherichia coli. J Agric Food Chem 31:|1071 - 1075
Biodegradation in water: screening tests, IUC4#100/Ch.3.5
Mitsubishi Gas Chemical Co., unpublished Report No. PIT-9204, 1992
Bioaccumulation: aquatic / sediment, IUC4#19/Ch.3.7
Exxon Biomedical Sciences Inc. (1996) Ready Biodegradability|: OECD 301F Manometric Respirometry Test. 136894A.
Lyman W. J. ; Environmental Exposure From Chemicals p.31 vol 1, Neely WB, Blau GE(eds), Boca Raton, FL: CRC Press(1985)
reproduction output, mortality and mobility
Salmonella typhimurium TA 1535, TA 100, TA 1537, TA 98 and E. coli WP2 uvrA
US National Toxicology Program (2002): NTP unpublished|results. NTP Test Results Report. Results, status and|publication information on all NTP chemicals produced from|NTP Chemtrack system. Electronic publication, available at|http://ntp-support.niehs.nih.gov/htdocs/NTP_Results.pdf.
Method: other: after Haworth et al (1983): Environ Mutagen 5(suppl 1): 3-142.
Bacterial reverse mutation assay. Standard plate and Preincubation test using S. typhimurium TA100, TA1535, TA98, TA1537
Schultz, T.W., S.E. Bryant, and T.S. Kissel (1996): Toxicological Assessment in Tetrahymena of Intermediates in Aerobic Microbial Transformation of Toluene and p-Xylene. Bull.Environ.Contam.Toxicol. 56(1):129-134.
BASF AG, Toxicology Research Department, study report|26M0015/914321, 17 Mar. 1993
Olivier, Ph. and Marzin, D. (1987) Study of the genotoxic|potential of 48 inorganic derivatives with the SOS|chromotest. Mutation Res., 189, 263-269.
Vogel EW, Frei H, Fujikawa K, Graf U, Kondo S, Ryo H,|Würgeler FE (1985) Summary report on the performance of|Drosophila assays. Prog Mut Res 5: 47-57
Method: other: according Graf et.al., 1983
Nersesyan AK, Kukumadzhyan VA, Zil'fyan VN (1990). Evaluation of activity of some chemical substances being in use in the industry of Armenia. Biol. Zh. Armen. 43, 796-797.
Covance Laboratories (1998). Formi LHS. 13 week oral|(dietary administration) toxicity study in the rat with a 4|week treatment-free period. Unpublished final study report|No. 1516/6-D6154 dated April 1998. Sponsored by Hydro|Nutrition, Oslo.
WIL Research Laboratories, LLC (2006) A|REPRODUCTION/DEVELOPMENTAL TOXICITY SCREENING STUDY OF|METHYL ETHYL KETONE PEROXIDE IN RATS STUDY NUMBER|WIL-497004. Appendix A: Preliminary 5-Day Study. 14 March|2006.
Union Carbide Corp. (1979). Specialty Alkyl Alkanolamines.|Technical leaflet, New York.
Procter and Gamble Co. (1974). Two year chronic toxicity and|study of brightener 3 in the rat. 25 November 1974. As|submitted to U.S. EPA under TSCA on Aug. 26 1992, U.S. EPA|TSCA OTS-538662.
Shelton D.R. and Tiedje J.M. Appl. Environ. Microbio. |47(4):850-857. (1984)
Schering AG, Experimentelle Toxikologie. 1998. Acute toxicity of di-n-butyltin oxide (ZK 26385) to the Zebra fish Danio rerio. Research Report No. IC19. Berlin, Germany. 19 November 1998.
Method: other: OECD Guideline 203; OECD ENV/JM/MONO (2000)6 - Guideance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures (26 June 2000)
Topchyan, M.S., Aver`yanova, K.G. (1955). Kvoprosy|izucheniya toksicheskish svoistv khloristogo kaliya dlya|melkogo pogotato skota. Izv. Akad. Nauk Arm. SSR Biol. Skh|Nauki. 8:59-62. (cited in FASEB 1979).
Tobe, M. et al.: Toxicology 58, 79-86 (1989), No information
Huels AG (1988a). Prüfung auf hautsensibilisierende Wirkung|am Meerschweinchen von Isophoron. Report No. 1278|(unpublished).
Allied Corporation. Evaluation of Silane, Trimethoxy|[3-oxiranyl methoxy)propyl] for Transformation Activity in|Secondary Hamster Embryo Cells. Fiche Number 215156.
Zhang Y, Yu H, Han S, Zhao Y, Wang L (1995) The Toxicity of|Substituted Aromatic Compounds to Algae and Quantitative|Structure-Activity Relationship Studies. Huanjing Huaxue 14|(2): 140 - 144
Hundley S.G. et al. (1994) Toxicology Letters 73, 213-225
CIBA-GEIGY, Ltd. Genetic Toxicology. 1992. Bacterial Mutagenicity Screening Test of TK 11638 (Irgastab T 22 M). Test No. 924151. Basle, Switzerland.
Method: other: SOP - CIBA-GEIGY Genetic Toxicology (based on current standard methods)
mouse embryo, 48 and 144 h post conceptionem
Harrington, T.R. & Nestmann, E.R., Prog. Mutat. Res. 5,|257-260 (1985)
Geiger DL, Poirier SH, Brooke LT, and Call DJ (1984). Acute|Toxicities of Organic Chemicals to Fathead Minnows|(Pimephales Promelas). Volume 3. Ed. by DL Geiger, SH|Poirier, LT Brooke, and DJ Call. Center for Lake Superior|Environmental Studies, University of Wisconsin-Superior,|177-178. (Also cited in Aquire)
Mitsubishi Gas Chemical Co., unpublished Report No. ATT-8308, 1974, Acute Toxicity Test of m-Toluic Acid
Short-term toxicity to fish, IUC4#58/Ch.4.1
Method: other: according to Ashby et al., Mutat. Res. 156, 1-18 (1985)
Horowitz A, Shelton DR, Cornell CP, Tiedje JM (1982) Anaerobic degradation of aromatic compounds in sediments and digest sludge. Developments in Industrial Microbiology 23:435-444.
Monsanto Co (1985b) Evaluation of the potential of|p-Nitrochlorobenzene to induce unscheduled DNA synthesis|(UDS) in primary rat hepatocyte cultures. Monsanto Study|No.: SR-84-407, 09. Sept. 1985, EPA-OTS0557078 and|EPA-OTS543012
Karplyuk, I.A. (1959): Vopr. Pitaniya 18, 24 - 29
Method: other: plate incorporation method, incubation 48 hours, in aerobic and in anaerobic conditions, solvent: ethanol abs., solvent control, no positive controls, duplicates, evaluation as pos.: >2-fold than spontaneous revertants
Salmonella typhimurium strains TA98, TA100
Anderson D, Styles JA (1978). The bacterial mutation test.|Br. J. Cancer 37, 924-930.
Method: other: according to Ames, B.N. et al., Mutation Res. 31, 347 (1975): plate incorporation methodology
Khorana, Pandit, Pishawikar (1967): J. Pharm. Sci. 56(8),|993-997
Hjørnevik L (1997). The chemical behaviour of potassium|diformate in water solutions. A comparison with formic acid.|Project No. R31122000, Research Centre Porsgrunn.
Method: other: recording of pH values of solutions when diluted and neutralized (titer curves)
Salmonella typhimurium TA97, TA98, TA100, TA1535
Covance Laboratories (2004). Formi LHS: Target species|safety study in the farrowing pig. Covance Report Number|1516/034-D6154 dated February 2004. Sponsored by Hydro|Formates AS, Norway.
Xie D.Y. et al., Environ.Mol.Mutagen., 14(Suppl.15), 222-223|(1989)
Salmonella typhimurium TA1535, TA1537, TA98, TA100, and TA102; Escherichia coli WP2 uvrA
Chemical Inspection and Testing Institute, Japan (1999):|report on biodegradation
Sax, N.I. and R.J. Lewis, Sr. 1987. Hawley's Condensed Chemical Dictionary. Eleventh Edition. Van Nostrand Reinhold Company. New York, NY. 1288p.
Alexander HC and Batchelder TL (1975) "The pollutional evaluation of compounds", unpublished report of the Dow Chemical Company.
Wallen IE, Greer WC, Lasater R (1957). Toxicity to|gambusia affins of certain pure chemicals in turbid waters.|Sewage and Industrial Wastes, 29, 695-711.
Method: other: Recommendations of Committee on Research were followed (Doudoroff et al., 1951)
Method: other: range-finding study for OECD TG 422
Williams, G.M. et al. (1990): Food Chem. Toxicol. 28, |793 - 798
Method: other: Williams et al., Mutat. Res. 97, 359-370 (1982)
DeSerres, F.J. er al.: Mutat. Res. 199, 235-242 (1988), No information
Genetic toxicity in vitro, IUC4#64/Ch.5.5
BASF AG (2002). Experimental Toxicology and Ecology, Triphenylphosphin - Determination of the inhibitory effect on the cell multiplication of unicellular green algae, Unpublished Report, Study No. 99/0479/60/1, 02 July 2002.
Leung HW, Paustenbach DJ (1990). Organic acids and bases:|Review of toxicological studies. American Journal of|Industrial Medicine 18, 717-735.
National Institute of Environmental Research(NIER), Korea(2001), Test of Acetanilide Partition Coefficient (n-octanol/water)(tested by KRICT)
Place, A.R. et al. in: Elzinga, M. (ed.): "Methods in|Protein Sequence Analysis", Humana Press, Clifton, New|Jersey (1982), pp. 373-379, No information
Method: other: in vivo chromosomal aberrations - eukaryotes (non-mammalian/Drosophila)
Genetic toxicity in vivo, IUC4#38/Ch.5.6
Deneer, J.W. et al., Quantitative structure-activity|relationships for the toxicity and bioconcentration factor|of nitrobenzene derivatives towards the guppy (Poecilia|reticulata), Aquatic Toxicology 10, 115-129 (1987)
Sugimura et al. (1974). In: Odashima S., Summary report.|Development of screening methods for carcinogens. Japanese|Ministry of Health and Welfare. As cited in: Tanooka H|(1977): Development and Applications of Bacillus Subtilis|Test Systems for Mutagens, Involving DNA-Repair Deficiency|And Suppressible Auxotrophic Mutations. Mutation Research|42, 19-32
Method: other: ex vivo (in vitro/in vivo) DNA damage - eukaryotes (mammalian cells/SCE)
Litton Bionetics (1978) "Mutagenicity Evaluation of Isobutyl Alcohol in the Mouse Lymphoma Forward Mutation Assay", final report (LBI Project No. 20989) to Celanese Chemical Corp., November, (1978); cited in TSCATS: OTS 0532868, Doc.I.D.: 40-91114031, 09.19.1991, OXO Panel CMA, (1991) as cited in IUCLID.
Hadidian, Z. et al., J.Natl.Cancer Inst., 41: 985-1036|(1968)
Ministry of Environment, Japan (1999a): unpublished report on acute toxicity to fish
Method: other: Batch-Test, Evaluation of the degradation and of the degradation rate, based on the reduction of the chemical oxygen demand and TOC
An inhalation developmental toxicity study in rabbits with|HCFC-124. Bio/dynamics Inc., Millstone, New Jersey, Project|No 89-3514. December 1991. Study performed for PAFT III.
EPA OTS 798.4900 (Prenatal Developmental Toxicity Study)
BASF AG, Laboratory of Ecology, unpublished data, |(0064/88)
Method: other: Pseudomonas-cell multiplication inhibition test, DIN 38412/8, draft
Boominathan, Mahadevan (1989) Zentralbl. Mikrobiol. 144:37-45.
Gilbert, S.G. and Rice, D.C.: Fund. Appl. Toxicol. 16,|299-308 (1991)
Union Carbide Corp. Bushy Run Research Center,|Project Report No. 29-126. Export, PA. 1966.
Method: other: Acute oral by gavage, method/guideline followed: Internal Union Carbide method (intubation). The moving average method of calculating median-effective dose was used based upon a 14-day observation period.
Courtes, R.,et al., Ready Biodegradability Test in Seawater:|A New Methodological Approach. Ecotox Environ. Safety|31:142-148 (1995)
Hoechst AG (1988): Unveröffentl. Unters. (Ber.-Nr. 88.0373)
Zhongfu C et al. (1987): Test of 30 Chemicals for Potential|Genotoxicity with Inductest. J Fudan Univ (Natural Science)|26(2), 137-142 (in Chinese)
Genetic toxicity in vitro, IUC4#45/Ch.5.5
Keating, J.W., Report to RIFM (1972) cited in Opdyke, Fd.|Cosm. Toxicol., 13, 859, 1975
Donner M, Husgafvel-PursiainenK, Jenssen D, Rannug A (1983)|Mutagenicity of rubber additives and curing fumes. Scand J|Work Environ Health 9 Suppl 2: 27-37
Hoechst AG (1993), Pharma Development Central Toxicology.|Betanaphthol - Testing for acute dust inhalation toxicity in|the male and female SPF Wistar rat, 4-hour LC50. As cited|in: Berufsgenossenschaft der chemischen Industrie (1995):|Toxikologische Bewertung. Beta-Naphthol. Nr. 135, Heidelberg
Vighi, M. and D. Calamari. 1985. QSARs for organotin compounds on Daphnia magna. Chemosphere. 14(11/12):1925-1932.
DeFulvio, S. et al. Biotic Degradation of organic |compounds in seawater: shake-flask method. Rapp. Istisan |1123-3117 (1985)
1-chloro-1,1-difluoroethane (IUC4 DSN 42)
Method: other: NEN 6501: Determination of acute toxicity with Daphnia magna (1980) with slight modifications (Van Leeuwen et al. 1985b)
Bridie A.L. et al (1979), Water Research, 13(7), 627-30.
BOD5 Method: other: APHA "Standard Methods" No 219 at 20 +- 1 °C
Balander, P.A., Polyak, M.G., 1962. Toxicological|characteristics of methyl bromide. J. Gig. I. Tokskol.|60:412-419.
Nozawa, Maruyama. (1988): J. Bacteriol. 170, 2501-2505
BASF AG, Department of Product Safety, unpublished|screeening test, 00/00598-3, 29.01.2003
Method: other: following: Jap. Ind. Standard (JIS) K 0102 Item 55, Acute Toxicity Test by Fishes (1974) and Proposal on Standard Tlm Test with Orange-Red Killifish. Kenji Tabata, Yosui To Haisui, 14, 1297-1303 (1972)
BASF AG, 1982, Analytical Laboratory, Dampfdruck von|beta-Ionon, unpublished study, J.Nr. 47-1028, 27 Aug. 1982
Soffritti, M. et al.: Toxicol. Ind. Health 5, 699-730 (1989), No information
chinese hamster ovary cells (CHO-K1-BH4)
Chemicals Evaluation and Research Institute (2004). Final|Report of Biodegradability Study of 4-ethylmorpholine.|Report Number 205038.
Gulf Coast Research Laboratories. 1992. Acute toxicity of Dibutyltin Dichloride to the Sheepshead Minnow (Cyprinodon variegatus). Contract No. ES-7339, Subtask 2D. Sponsored by the Consortium of Tributyltin Manufacturers [M&T Chemicals, Inc., Woodbridge, NY and Sherex Chemical Co., Inc., Dublin, OH]. October 27, 1992.
Method: other: USEPA, Method for Acute Toxicity Tests with Fish, Macroinvertebrates, and Amphibians (EPA-660/3-75-009)
Ma, T.H. and Harris, M.M.: Environ. Mutagen. 9, 65 (1987);|abstract no. 166, No information
Leo, A. Hansch, C., and Elkins, D., Partition coefficients|and their uses, Chemical Reviews 71, 525 - 568 (1971)
Gonsior, S.J., West, R.J., (1991). Biodegradation of Dowanol PM, Dowanol PPH, and Dowanol PMA glycol ethers in soil. Dow Chemical Company Study No. ES-2232. November 8, 1991. Unpublished study.
Method: other: OECD protocol not referenced, but the report provided documentation that the study was conducted to standards provided in OECD Protocol 304 "Inherent Biodegradability in Soil."
Van Duuren B., et al., 1971, Cocarcinogenesis studies on mouse skin and inhibition of tumor induction, J. Nat. Cancer Inst. 46(5): 1039-1044
BASF SE (2008). N-(2-aminoethyl)ethanolamine. Enhanced|Reproduction/Developmental Toxicity Screening Test in Wistar Rats. Oral Administration (Gavage). Unpublished study report No. 90R0019/01195 dated 30 April 2008.
Inversk Resarch International(IRI).(1991c), Primary eye|irritation test in rabbits. Report No.6917, Unpublished|report
Abraham, S.K. and Kesavan, P.C.: Mutat. Res. 53, 142 (1978);|abstract no. 2
Genetic toxicity in vivo, IUC4#47/Ch.5.6
Method: other: according to Smyth et al., Am. Ind. Hyg. Ass. J. 23, 95-107 (1962), LD50 was calculated by the use of probit method
Genetic toxicity in vivo, IUC4#52/Ch.5.6
White, D.F. and Mullee D.M. (2004), "E-Caprolactone:|Determination of boiling point and water solubility",|SafePharm Laboratories Ltd Project Number 1524/003
Garner, R.C. & Campbell, J., Prog. Mutat. Res. 5, 525-529|(1985)
Salmonella Typhimurium, TA 98, TA 100, TA 1535, TA 1537, TA 1538
Method: other: according to OECD Guide-line 482, negative, vehicle and positive control (2AAF)
BASF AG, department of toxicology, Pruefung der akuten|Hautreiz-/Aetzwirkung an der intakten Rueckenhaut wiesser|Kaninchen in Anlehnung an OECD; Pruefung der akuten|Reizwirkung am Auge weisser Kaninchen in Anlehnung an OECD,|unpublished results (85/209), 10-17-85
Litton Bionetics 1975. Unpublished data submitted to US Food|& Drug Administration, cited in "Interim Scientific Report|by Federation of American Societies for ExperimentalBiology|prepared for National Cancer Institute (PB 85-122513).
The Merck Index (1989). 11th edition. Merck and Co., Inc., Rahway, New Jersey, p. 1533.
Salmonella typhimurium TA97, TA98, TA100, TA102
CITI, Japan (1999) Report No. 81369, Chemicals Inspction and Testing Institute, unpublished data
Price KS, Waggy GT and Conway RA (1974). Brine shrimp|bioassay and seawater BOD of petrochemicals. J. Water|Pollut. Control Fed. 46, 63-77.
Method: other: Standard Method for the Examination of Water and Wastewater, APHA
SafePharm Laboratories Ltd.,Derby (1996): Micronucleus Tset in the Mouse. Project No.521/004
Method: other: other: Directive 92/69/EEC, B.12 "Genetic Toxicology: Micronucleus Test"
Bayer AG, Thyssen J (1979) Untersuchungen zur Haut- und|Schleimhautverträglichkeit. Short report dated March 19,|1979
Repeated dose toxicity: inhalation, IUC4#83/Ch.5.4
Ewell WS, Gorsuch JW, Kringle RO (1986) Simultaneous|Evaluation of the Acute Effects of Chemicals on Seven|Aquatic Species, Environmental Toxicology and Chemistry 5,|831-840
BASF (1989): Study of the acute toxicity of Natriumsulfit|Wasserfrei A to Golden orfe. BASF AG, Department of|Toxicology, Proj. No. 10F0639/885041, Jun 20, 1989
Safepharm Laboratories Ltd., Derby (1994a): Metaphase Analysis in Human Lymphocytes in Vitro. Project No. 521/1
Smith, A.L. (1988) Physical and Thermodynamic Properties|- Ethyl-, Methyl-, and Vinyltriacetoxysilanes. Dow Corning|Corporation, Report No. 1988-I0032-112.
Method: other (calculated): Smoothed data by fitting it to Halm & Stiel CSP correlation
Sasaki YF, Fujikawa K, Ishida K, Kawamura N, Hishikawa Y,|Ohta S, Satoh M, Madarame H, Ueno S, Susa N, Matsusaka N,|Tsuda S (1999) Erratum to: The alkaline single cell gel|electrophoresis assay with mouse multiple organs: results|with 30 aromatic amines by the IARC and U.S. NTP. Mut Res|444: 249-255
Brooke L.T., Call D.J., Geiger D.L. and C.E Northcott, 1984,|Acute toxicities of organic chemicals to fathead minnows|(Pimephales promelas), Center for Lake Superior|Environmental Studies, University of Wisconsin-Superior
Weast, R.C. and Grasselli, J.G. (eds.): CRC handbook of data|on organic compounds. CRC Press, Inc. Boca Raton, FL, 2nd|ed. (1989)
US EPA (Environmental Protection Agency) (2000) EPIWIN v3.10
Method: other (calculated): EPIWIN v3.10
BASF AG, Department of Toxicology. Report on the study of|AEEA in the prenatal developmental toxicity study in Wistar|rats. Unpublished study no. 30R0019/01105, 10 Jun 2003.
Method: other: Estimation using WSKOW (ver. 1.40)
Degussa AG (2005). Personal communication of July 27, 2005.
Lijinsky W (1988) Chronic Studies in Rodents of Vinyl|Acetate and Compounds Related to Acrolein, Annals New-York|Academy of Science 534, 246-254
BASF AG, 2003, Department of Product Safety, Laboratory of|Ecology, Determination of the acute effect of "78% choline|chloride dissolved in water" on Daphnia magna Straus,|unpublished data, reprint of report No. 0111/2/88-0111/88|(08 Apr 1988), 16 Sept 2003
Method: other: according to Directive 79/831 EEC, C2
Method: other: 5 rats/sex/group, whole body exposure, for further information see freetext ME
van Ginkel, C.G., Kroon, A.G.M. and Mark, U. (1990) Algal|inhibition test with N-aminoethylpiperazine. Unpublished|report CRL F90085 of Akzo Nobel.
BASF AG, Department of Toxicology, unpublished data|(XXIII/533) 10/3/1974
ECDIN Environmental Chemicals Data and Information Network|Joint Research Centre (IRC) of the Commission of the|European Communities (CEC), Ispra, Italien as quoted in|DIMDI (2003) database: CIVS Chemikalieninformationssystem zu|verbraucherrelevanten Stoffen (c) of the BfR Bundesinstitut|für Risikobewertung. Document No. 0003010, Date 29.12.2000
Younger Laboratories, Toxicological investigation of|orthonitrochlorbenzene residue, at the request of Monsanto|Co., EPA OTS0538609, 1992
Method: other: 3 rats/dose, single oral application of undiluted substance, observation time: 14 d
Genetic toxicity in vitro, IUC4#146/Ch.5.5
SPARC On-Line Calculator (2009) pKa calculations, v 4.2, http://ibm1c2.chem.uga.edu/sparc/index.cfm, Jan 2009
IITRI. 1988. Thirteen-week inhalation toxicity study of|trimellitic anhydride in rats. Final Report. IIT Project|No. L8100, Study No. 899, Test Article No. 128.
Wu C-D, Wei D-B, Liu X-H, Wang L-S (2001) Estimation of the|Sorption of Substituted Aromatic Compounds on the Sediment|of the Yangtse River. Bull Environ Contam Toxicol 66: 777 -|783
Degussa (2004g). Degussa AG, Dr. H. Brachhold personal|communication on the evaluation of the hydrolysis studies|with DMM and DEM of 15.10.2004.
Pietr SJ, Witek W, Witek R, Koll A, Kubis A (1989). Studies|on antifungal properties of phenol complexes with secondary|amines. 1. The effect of complex formation of nitro- and|chlorophenols with dicyclohexylamine on the antifungal|activity in vitro. Mycoses 32 (7), 359-361.
Method: other: Cup Plate Assay (Growth Inhibition)
Lyman WJ, Reehl WF, Rosenblatt DH (1990) Handbook of|Chemical Property Estimation Methods. Washington DC. Amer|Chem Soc, 7-4, 7-5
Mesch, K.A. and T.G. Kugele. Morton International. 1992. Use of Organotin Stabilizers - Risk Assessment Analysis. J. Vinyl Tech. 14:131-134.
Fassett, D.W.: S. 1968 in: Industrial Hygiene and|Toxicology, Ed. Patty F.A. New York-London-Sidney 1962
BASF (1981) Respirometric test (mucochloric acid purified|technical grade; adapted inoculum). BASF AG, Dpt. of|Ecology, 21.09.1981 (unpublished data; Reprint of|18.07.2002)
Biodegradation in water: screening tests, IUC4#28/Ch.3.5
Markova TH: Studies on Mineralization of Nitrogen from|Slow-Acting Nitrogen Fertilizers -|Urea-Aldehyde-Condensates. Zbl. Bakt.II Abt.133, 146-153,|(1978)
Mendrala AL (1983) "Evaluation of DOWANOL* PM in the rat hepatocyte unscheduled DNA synthesis assay", unpublished report of the Dow Chemical Company.
OECD Guideline 482 (Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells In Vitro)
Gaunt, I.F., J. Colley, P. Grasso, M. Creasey, and S.D. Gangolli. 1968. Acute and short-term toxicity studies on di-n-butyltin dichloride in rats. Food Cosmet. Toxicol. 6:599-608.
Salmonella typhimurium strains TA 1535, TA 97, TA 98, TA 100
Bayer AG (1975). Internal report: Acute Fish Toxicity of|N,N-Dicyclohexylamine. Report rewritten 2001-03-22.
Method: other: standard Syrian hamster embryo cell transformation assay modified for reduced pH in the culture medium
Crompton (2001) Material Safety Data Sheet Silquest A-1120|silane Revision 1.4 05/17/2001
Method: other: in conformance with OECD 404
Verschueren K (1983). Handbook of Environmental Data on|Organic Chemicals, 2nd edition. Wiley-Interscience, New|York, 873.
Huntingdon Research Centre Ltd. (1987) Mouse micronucleus|test on Isobutyltriethoxysilane. Report DNN 15/8833|Degussa-Huls AG-Nr.: 88-0349-FKM May 13, 1988
Method: other: according Zimmermann (1975)
Central Glass Co., Ltd., unpublished report (2003)
Method: other: differential scanning calorimetry
Fluka Chemical Corporation (1990) Chemika Biochemika. Fluka|Chemical Corporation, Ronkonkoma, NY, 1990 Fluka Catalog.
Method: other: according Zimmerman, 1975
BASF AG, Verfahrenstechnik, unveröffentlichte Untersuchung,|Bericht 185.0552.2, 18.12.1985
Ivanov YG, Rudakova EV, Chamaev VN, and Matsukov YE (1988).|Biochemical clean-up of wastewater containing|N-Methylpyrrolidone. Khimicheskie Volokna 5, 23-24.
Greif N (1967). Cutaneous safety of fragrance material as|measured by the Maximization test. American Perfumer and|Cosmetics 82, 54-57
Method: other: Kligman Maximization test
Bringmann G (1975). Bestimmung der biologischen Schadwirkung|wassergefaehrdender Stoffe aus der Hemmung der|Zellvermehrung der Blaualge Microcystis.|Gesundheits-Ingenieur 96 (9), 238-241.
Method: other: WSKOW v. 1.40 in EPIWIN suite, estimate reflecting melting point (assumes no hydrolysis)
BASF (1976) Sicherheitstechnische Kenndaten, TLM/SIK|75/1379, 21.05.1976
Belly R & Goodhue C., A radiorespirometric technique for|measuring the biodegradation of specific components in a|complex effluent, Proc. 3rd Int. Biodegradation|Symp., 1103-1107, 1976 (91)
Appearance/physical state/colour, IUC4#30/Ch.1.1.1
Verschueren K., Handbook of Environmental Data on Organic|Chemicals, sec. Ed., Van Nostrand Reinhold, New York, 1983, No information
Monsanto Co. (1982) Ames/Salmonella mutagenicity assay of|3,4-dichloronitrobenzene (technical, "nitrated orthene," CP|010379). Monsanto Co., St. Louis (OTS0534377, 86-920000172)
Method: other: according to Ames BN et al. (1975) Mutat Res 31, 347-364, see also Freetext ME
Hughes DW (1981). Malonic acid and derivatives in: Kirk|Othmer, Encyclopedia of chemical technology, 3rd ed. (14),|796-810.
Toxicity to aquatic algae and cyanobacteria, IUC4#11/Ch.4.3
Appel, M.J. and D.H. Waalkens-Berendsen. Trichlorooctylstannane [CAS # 3091-25-6]: Sub-chronic (13-week) oral toxicity study in rats, including a reproduction/developmental screening study. TNO Nutrition and Food Research. TNO Report V3963, July 2004.
FMC Corporation, Sodium persulfate:|Salmonella/mammalian-microsome plate incorporation|mutagenicity assay (Ames test), Study no. I90-1119, 1990.
Hoechst AG (1992): Unveröffentl. Unters. (Ber.-Nr. W87-0417)
Sicardi, S. M., Martiarena J.L., Iglesias M.T. Mutagenic and analgesic activities of aniline derivatives. J. Pharm. Sci. 80(8), 761-764, 1991
Brooke LT, Call DJ, Geiger DL, and Northcott CE (1984).|Acute Toxicities of Organic Chemicals to Fathead Minnows|(Pimephales Promelas). Volume 1. Ed. by LT Brooke, DJ Call,|DL Geiger, and CE Northcott. Center for Lake Superior|Environmental Studies, University of Wisconsin-Superior,|241-242. |(also cited in Aquire)
Handbook of Environmental Data on Organic Chemicals, 4th|Edition, Copyright ©2001 by John Wiley & Sons, Inc.
Appearance/physical state/colour, IUC4#7/Ch.1.1.1
Lunt OR and Clark SB, Properties and value of 1,1-diureido|isobutane (IBDU) as a long-lasting nitrogen fertilizer. J.|Agric. Food Chem. 17, 1269-1271 (1969) cited in: Hughes TD:|Nitrogen Release from Isobutylidene Diurea: Soil pH and|Fertilizer Particle Size Effects. Agron. J. 68, 103-106|(1976)
Yuan, Lang (1997): Bull. Environ. Contam. Toxicol. 58,|123-127
Method: other: Alsop G.M., Waggy G.T., Conway R.A. (1980): Bacterial growth inhibition test J. WPCF 52: 2452
Florin I, Rutberg L, Curvall M, Enzell CR (1980) Screening|of tobacco smoke constituents for mutagenicity using the|Ames' test. Toxicology 15, 219-232
Riach, C.G. and Willington, S.E. 1994. P.I.A. Purified|Isophthalic Acid Mouse Lymphoma Mutation Assay. Inveresk|Research International (IRI) Project No. 755466.
Hanley TR et al. (1984) Fund Appl Toxicol, 4, 784-794.
BASF AG, Department of Product Safety, Expert Judgment on|Hydrolysis, 10 Nov. 2004
BASF (2007) Determination of the acute effect on the swimming ability of the water flea Daphnia magna STRAUS.
BASF AG, Safety Data Sheet N-METHYLPYRROLIDON DIST., 20.07.2005
Takahashi, M. et al.: Jpn. J. Cancer Res. 77, 118-124 (1986), No information
Biodegradation in water: screening tests, IUC4#36/Ch.3.5
Nelson, B.K., Brightwell, W.S., MacKenzie-Taylor, D.R., Khan, A., Burg, J.R., and Weigel, W.W.
Developmental toxicity / teratogenicity.004
BASF AG (1966). Department "Technische Entwicklung Verfahrenstechnik", vapour pressure, Unpublished Report, J.Nr. 37-824, 18 November 1966.
Method: other (measured): dynamic (Ramsay-Young)
Ministry of Health and Welfare: Japan, Toxicity Testing Reports of Environmental Chemicals 4, 537-546 (1996)
MITI (Ministry of International Trade and Industry) (1992).|Biodegradation and Bioaccumulation Data of Existing|Chemicals based on the Chemical Substances Control Law|(CSCL). Japan. Chemicals Inspection and Testing Institute|(CITI, ed.); Japan Chemicals Industry Ecology Toxicology and|Information Center 1-27, 3-28.
BASF AG, (1978b) Cytogenetic investigation in the bone marrow of chinese hamsters after 4-day inhalation, Dept. of Toxicology, unpublished study, (XXVI/352), April 20, 1978
BUA: Chloromethane. BUA Report 7. Ed. GDCh-Advisory|Committee on Existing Chemicals of Environmental Relevance|(BUA), VCH Publisher, Inc, New York (1986).
Method: other: 3 drops(10% sol.) to the clipped area of the skin;22nd inj.of Freund-adjuvans and TS into the hind paw (0.5 mg/kg bw), 28th d 3 drops(10 % sol.) to an untreated clipped area of the skin; reading time not mentioned
Ministry of the Environment (MOE), Japan(2000) Unpublished report conducted by Mitsubishi Chemical Safety Institute Ltd.
BASF AG, Sicherheitsdatenblatt Ammoniumchlorid n.a.|(29.04.1994)
Parry, J.M. & Eckardt, F., Prog. Mutat. Res. 5, 285-295|(1985)
Biodegradation and Bioaccumulation Data of Existing|Chemicals. (1992). Based on the CSCL, Japan. Compiled under|the supervision of MITI, Japan.
Salmonella typhimurium TA 97 /TA 102(II)
Tisler, T. and Zagorc-Koncan, J., Water, Air and Soil|Pollution 97, 315 - 322, 1997, No information
Method: other: according to the OECD standard
Kato, H.: Expl. Cell Res. 88 (2), 239-247 (1974);|cited in: RIFM database, location no. 7198
The vapor were produced when liquid chemical was delivered by a syringe pump into a heated evaporator through which metered air was delivered to generate the desired concentration. The resultant vapors were flushed into a 9-liter dessicator which served
Repeated dose toxicity: oral, IUC4#64/Ch.5.4
Battelle Pacific Northwest Laboratories. 1991. Static Acute 48-hour Toxicity Test of Dibutyltin Dichloride (DBT) to Oyster Larvae. BNW No. 12716. Study sponsored by The Consortium of TBT Manufacturers (Atochem NA, Inc. and Sherex Chemical Co., Inc.). March, 1991.
Method: other: study protocol based on USEPA (1982, 1985) and ASTM (1980) guidelines
EPA's ECOSAR model (v. 0.99f). EPISUITE v.3.10, U.S.|Environmental Protection Agency, April (2001).
Mortelmans K, Haworth S, Lawlor T, Speck W tainer B and|Zeiger E (1986) Salmonella mutagenicity test: II, Results|from the testing of 270 chemicals. Environ Mutagen, 8 suppl|7, 1-119.
Hoechst AG (1977a) Akute orale Toxizität von|p-Nitrochlorbenzol an männlichen SPF-Wistar Ratten.|Unveroeffentl. Unters. Bericht: 77.0170, 8. März 1977
Method: other: 10 rats/dose, TS disssolved in sesame oil, observation time 14 days, pathologic examination, statistical analysis
BASF AG (1971). Department of Toxicology, dermal and eye irritation, unpublished study, Study No. XXI/183, 22 December 1971
Seinen, W., J.G. Vos, I. Van Spanje, M. Snoek, R. Brands, and H. Hooykaas. 1977. Toxicity of Organic Compounds. II. Comparative in vivo and in vitro studies with various organotin and organolead compounds in different animal species with special emphasis on lymphocyte cytotoxicity. Toxicol. Appl. Pharmacol. 42:197-212.
The Dow Chemical Company, unpublished report (dermal|sensitization) (1992)
Kurume Research Laboratories,Chemicals Inspection & Testing|Institute, Japan, February 28, 1992. Test on|1-octanol/water partition coefficient of HCFC-32, report n°|80678.
Groeneveld, A.H.C. and Kuijpers, L.A.M., (1990) The Acute|Toxicity of 1-chloro-1,1-difluoroethane (HCFC 142b) to|Daphnia Magna. Report N° 56635/32/90 DUPHAR B.V.
Genetic toxicity in vitro, IUC4#190/Ch.5.5
Hoechst AG (1993): Unpublished study. Beta-Oxynaphthoesäure|(BONS). Chromosome Aberrations. in vivo Cytogenetic Test in|Bone Marrow Cells of the Chinese Hamster. (Ber.-Nr.|93.0733), 19 Oct 1993
Bayer AG Data as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
BASF AG, (1958) Report on the study of the acute oral toxicity in the rat, Dept. of Toxicology, unpublished study, (VII/310), Dec. 9, 1958
Sipi P, Järventaus H, and Norppa H (1992). Sister-chromatid|exchanges induced by vinyl esters and respective carboxylic|acids in cultured human lymphocytes. Mut Res 279, 75-82.
Izmerov NF, Sanotsky IV, Sidorov KK (1982) Toxicometric|parameters of industrial toxic chemicals under single|exposure. Moscow, Centre of International Projects: GKNT, 92
Salmonella TA97, TA98, TA100, TA1535, TA1537
Method: other: bodyweight gain determination, microscopic evaluation (no further data)
Kawachi, T., Komatsu, T., Kada, T. et al. (1980): Results of|recent studies on the relevance of various short-term|screening tests in Japan. Applied Methods in Oncology, 3,|253.
Central Institute for Nutrition and Food Research, TNO (1972): Determination of the acute oral toxicity of Benzoguanamine in rats, October 9, 1972
Bayer AG, unpublished data, 29.03.1979, cited in Bayer base|data set, last update 18.08.1994
Battelle Europe. 1993. A Study of the Acute Toxicity to|Fish (Leuciscus idus melanotus) of Trimellitic Anhydride. |Study Number: BE-EA-128-91-01-F3A-1.
Short-term toxicity to aquatic invertebrates, IUC4#34/Ch.4.2
Sigma Aldrich Product Information. http://www.sigma-aldrich.com/saws.nsf/ProductSearch?OpenFrameet (accessed September 25, 2000).
Environmental Chemicals Data and Information Network (1990) Commission of the European Communities (ECDIN; 1990).
Muzzall JM and Cook WL: Mutagenicity of Cosmetic Dyes using|the Salmonella / Mammalian Microsome Test (1978). Abstracts|of the Annual Meeting, p. 204, Abstract Q56
Method: other: spot test and plate incorporation assay
Bringmann G, Kühn R (1971) Biologischer Abbau von|Nitrotoluolen und Nitrobenzolen mittels Azetobacter agilis.|Gesundheits-Ing 92: 273 - 276
Method: other: simulation of a munition industrial sewage treament plant
Dow Chemical Company (1987). Preliminary toxicology information - isophorone diisocyanate. NTIS/OTS Microfiche 0517013, Doc 86-870002233.
Information Handling Services, Material Safety Data Sheets Service, Microfiche Ed. Bimonyhly Updates, August/September 1990, #5833-655, B-12
Covance Laboratories (1998). Formi LHS. Induction of|micronuclei in the bone marrow of rats. Unpublished study|report No. 1516/9-1052 dated April 1998. Sponsored by Hydro|Nutrition, Oslo.
EU Method B.12 (Mutagenicity - In Vivo Mammalian Erythrocyte Micronucleus Test)
IRDC (1973) Acute Inhalation Toxicity in the Albino Rat.|International Research and Development Corporation (IRDC).|Study #: 328-004. Study Date: October 31, 1973.
Method: other: Federal Hazardous Substances Act, Chapter II, Title 16 CFR; pre-dates OECD and GLP.
Method: other: Differential thermoanalysis
Rhone-Poulenc Inc. (1968) Support: Hexamethyldisilizane|Acute Toxicity in Mice and Topical Tolerance in Rabbits and|Guinea Pigs with Cover Letter dated 072293. Microfiche|OTS0533692-2; Document No. 8EHQ-0793-1346.
Bayer AG (2000). Study report on algae toxicity (Study No.|956 A/00 AL).
Method: other: Directive 92/69/EEC, C.3, comparable to OECD TG 201
Swenberg, J.A. et al.: Biochem. Biophys. Res. Commun. 72|(2), 732-738 (1976);|cited in: RIFM database, location no. 4042
Method: other: pilot study to set dose levels, post exposure period: 11 d, 5 mated rabbits/group, the rabbits were sacrificed on d30 of gestation
Alarie Y, Wakisaka I, Oka S (1973) Sensory irritation by|sulfite aerosols. Environ Physiol Biochem 3: 182-184
Developmental toxicity / teratogenicity, IUC4#26/Ch.5.8.2
ICSC (2000) Allyl Alcohol: International Chemical Safety|Cards No. 0095
NIOSH. 1976. Occupational Exposure to Organotin Compounds. US Department of Health, Education, and Welfare. Publication No. 77-115.
Tripathi RS and Sriwastwa VMS (1980). Effect of some|chemicals on oxygen consumption of Esomus dandricus|(Hamilton). Environment India 3, 49-51.
Grant, W.M. Arch. Ophthalmol, 44, 399-404 (1950)
Bayer AG (1974-1989). Information Card for 1,4-Dichloro-2-butene. Unpublished data.
Method: other: Bestimmung der biologischen Schadwirkung toxischer Abwaesser gegen Bakterien. DEV, L 8 (1968) modified
Method: other: UBA-Proposal "Letale Wirkung bei Brachidanio rerio" (1982.06.01)
Phillips Petroleum Company. Initial sumission: Toxicity|testing summary for alternative fluorocarbons with cover|letter dated 082492. Dupont Chem. OTS 0571901. 02 September|1992.
MOE Japan (1999). Ministry of Environment, Toxicity study of|choline chloride on the Orange killifish Oryzias latipes,|unpublished study, No. 1998-16
Suzuki J, Koyama T, Suzuki S (1983) Mutagenicities of|mono-nitrobenzene derivatives in the presence of norharman.|Mutation Res 120: 105-110
Method: other: preincubation method; TA98, TA100 without S9-mix; TA98 with S9 mix; TA98 with S9 mix + norharman (200 ug/plate), 4 replicate plates for each dose level
Schering AG. 1969. ZK-Nr.: 22.663. Dibutylzinndichlorid. Systemische Vertraglichkeitsprufung an Ratten bei einmaliger p.o. Verabreichung (DL50). Prot. Nr. 925. 17.7.1969.
Hoechst AG (1992): Unveröffentl. Unters. (92-0067-R1)
Lawrence N, McGregor DB (1985) Assays for the induction of|morphological transformation C3H/10T1/2 cells in culture|with and without S9-mediated metabolic activation. Prog Mut|Res 5: 651-658
Method: other: Reznikoff, C.A. et al. (1973): Cancer Res. 33, 3231-3238
Martin B.E. (1976). Du Pont-Haskell Laboratory-Unpublished|Data-Report nø 548-76-MR nø 2427-001 and reported in |TOXALL- Data Bank from Kennedy G.L. (1986). Drug Chem|Toxicol., 92(2):147-170.
Method: other: modified Ames test according Cline and McMahon, 1977, Res. Commun. Chem. Pathol. Pharmacol. 16, 523-533; pos. control: 2-AAF, Streptozotocin
Marhold J.: Prehled Prumyslove Toxikologie; Organicke Latky,|370 Avicenum, Prag (1986): zit. in RTECS, update 8909
ROEMPP Online, © 2003 Georg Thieme Verlag, status 18 March|2004
BASF AG (1990 a) Klimisch, H.-J. Prenatal Toxicity of 2-Methyl-1-Propanol in Rats after Inhalation. Project No. 67R057/88047. BASF Department of Toxicology, BASF Corporation. 6700 Ludwigshafen, West Germany.
Munch, J.C. & Schwartze, E.W., J. Lab. Clin. Med. 10, 985-996 (1925). Zit. nach: Toxikologische Bewertung, Nr. 96, 2-Methyl-propanol-1, Berufsgenossenschaft der Chemischen Industrie (1988) cited in IUCLID (2000).
BASF AG, Safety data sheet PRENOL, 15.11.2001
Migliore, L. et al.: Mutagenesis 4, 327-334 (1989), No information
Genetic toxicity in vivo, IUC4#132/Ch.5.6
IITRI. 1991b. Acute dermal toxicity study of trimellitic|anhydride in rabbits. Final Report. IITRI Project No.|L08100, Study No. 1700, Test Article No. 128I.
Method: other: Single dose applied to 240 cm2 patch
Williams, G.M. et al. (1990): Food Chem. Toxicol. 28, |799 - 806
Barrett RH (1985) Assays for unsheduled DNA synthesis in|HeLa S3 cells. Prog Mut Res 5: 347-352
Method: other: according Martin et al., 1977
Genetic toxicity in vitro, IUC4#108/Ch.5.5
Dupont de Nemours. Initial submission: Inhalation toxicity|study of fluor chlor refrigerants in the guinea pigs with|cover letter dated 101892. OTS 0556329. 14th August 1934.
BASF AG, Analytical Department, unpublished data, (04.03.81)
Martin, I.D. et al. (1993), Arch. Environ. Contam. Toxicol.|24(3), 381-388.
Long-term toxicity to aquatic invertebrates, IUC4#7/Ch.4.5.2
Dow Corning Corporation (1993) Report Number 1981-I0005-885.
Method: other: Department of Transportation Hazardous Materials Regulations; Part 173.240, Appendix A, published in September, 1976.
Crompton Corporation. 2003. Safety Data Sheet. Mark 292 (Dibutyltin bis(2-ethylhexyl thioglycolate)). Date of Issue: 02.02.2003.
Toze S, Zappia L (1999) Microbial degradation of munition|compounds in production wasterwater. Wat Res 33 (13): 3040 -|3045
Motorova TN, Noseko NN (1989). Study of the kinetics of|interaction of phosphorus trichloride with water. Obl.|Khimii Pestitsidov 30-34 (Ref. Zh., Khim. 1990, Abstr. No.|16O365 (cited according to German translation)).
BUA (1996) GDCh-Advisory Committee on Existing Chemicals of|Environmental Relevance (BUA) Report 208,|N-(1,3-Dimethylbutyl)-N'-phenyl-1,4-phenylene diamine|(6PPD). S Hirzel Wissenschaftliche Verlagsgesellschaft,|Stuttgart
Method: other (calculated): calculation according to Atkinson
Chinese hamster fibroblast cell line (CHL)
Schering AG. 1978. Mutagenicity Evaluation of Di-n-octylzinndichlorid in the Ames Salmonella/Microsome Plate Test. Final Report. Study conducted by Litton Bionetics, Inc. LBI Project No. 20988. November, 1978.
Method: other: Ames, et al.; McCann, et al.
Monsanto Study No. SR-81-47 as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
FMC Corporation, Acute toxicity of ammonium persulfate to|rainbow trout (Oncorhynchus mykiss), Study no. I92-1247,|1993.
Adema,D.M.M., van den Bos Bakker,G.H., TNO-report |(No.R 86/326a), 6-13, (1986)
Method: other: in accordance with OECD Guide-line 476
International Critical Tables of Numerical Data, Physics,|Chemistry and Technology, 1st edition, Vol IV, 1928
Thorgeirsson, A. (1978) Acta Dermatover Vol 58, 332-336.
RTECS: Gig. Truda Profzabol., 197, No information
WIL Research Laboratory (2003) "An inhalation two-generation reproductive toxicity study of isobutanol in rats." Study Number WIL-186013, WIL Research Laboratories, Inc., 1407 George Rd., Ashland, OH 44805-9281, sponsored by the Oxo-Process Panel of the American Chemistry Panel, 1300 Wilson Boulevard, Arlington, VA 22209.
Salmonella typhimurium TA98, TA100, TA1535, TA1537, Escherichia coli WP2 uvrA/pKM101
National Toxicology Program. Toxicity Studies of Isoprene|(CAS No. 78-79-5), Administration by Inhalation to F344/N|Rats and B6C3F1 Mice. United States Department of Health and|Human services, Public Health Service, National Institutes|of Health. NTP Technical Report No. 31 (in press).
Towle, P.H., Baldwin, R.H., Meyer, D.H. 1968. Phthalic|acids. IN: Kirk-Othmer Encyl. Chem. Tech. 2nd ed. 15: |444.
Ohta, T. et al.: Mutat. Res. 147 (5), 271 (1985);|cited in: RIFM database, location no. 11990
Atkinson R (1987). A structure-activity relationship for the|estimation of rate constants for the gas-phase reactions of|OH radicals with organic compounds. Int J. Chem. Kinet. 19,|799-828.
Method: other (calculated): AOP Computer Program, Vers. 1.53, Syracuse Research Center (based on Reference)
Phototransformation in air, IUC4#30/Ch.3.1.1
Allied Corporation (1982). Evaluation of|[3-Glycidoxypropyltrimethoxysilane] for Mutagenicity in|Salmonella Typhimurium. Allied Corporation Report No.|MA-168-81-5.
Cytotest Cell Research GmbH & Co. KG (1990). Micronucleus|assay in bone marrow cells of the mouse with|isophoronediamine, Project No. 189000 (Hüls AG,|unpublished).
Method: other: Directive 84/449/EEC, B.12; OECD Guideline 474 (1983)
Shimizu M, Yasui Y, Matsumoto N (1983) Structural|specificity on aromatic compounds with special reference to|mutagenic activity in Salmonella typhimurium - a series of|chloro-or fluoro-nitrobenzene derivatives. Mutation Research|116: 217-238
Koopman, T.S.M. and Pot, T.E. (1986) Primary irritation|study of anhydrous calcium chloride to the eye of the male|rabbit. Duphar Report No. 56645/42/86.
IBR (International Bio-Research) (1976). Akute Toxizitätsprüfung von "3-Isocyanatomethyl-3.5.5-trimethylcyclohexyl isocyanat" nach oraler Applikation an der Ratte. Report 1 - 4 - 382/1 - 76 (Veba-Chemie AG, unpublished).
Method: other: Based on "Appraisal of the safety of chemicals in foods, drugs and cosmetics" by the staff of the Division of Pharmacology, FDA (1959), complies with OECD Guideline 401 (1981)
Rinehart, WE, Rabbit Eye Irritation Study, Toxicological|Resources Unit, Bio/dynamics Inc., 1978.
S. typhimurium TA 92, TA 94, TA 98, TA 100, TA 1535, TA 1537
mouse lymphoma cell (L5178Y), TK+- heterozygote
Biodegradation in water: screening tests, IUC4#39/Ch.3.5
ToxiGenics (1981b). Primary Eye Irritation Study in Rabbits|of X-29381 Aminosilane, , Study 410-0746; October 21. 1981.
Method: other: similar to OECD Guide-line 405
Guseinov V.G., 1982, Okhrana Truda i Zdorov'ya Rabotayushch.|v Vedushch.Otraslyakh Prom-sti Azerbaidzhana Sumgait,|P.92-99.
Method: other: dynamic method in 800 l chambers
Muller, W. 1991. Isophthalsaure. Study of the Mutagenic|Potential in Strains of Salmonella Typhimurium (Ames Test);|Study No. 91.0006.
BfR (2006). CIVS database, Bundesinstitut fur|Risikobewertung, online available at|http://bfr.zadi.de/civs/suche.cfm, request 05 Jan 2006.
Chandler MJ, Zeiss CR, Leach CL, Hatoum NS, Levitz D, Garvin|PJ, Patterson R, 1987. Levels and Specificity of Antibody in|Bronchoalvaolar Lavage (BAL) and Serum in an Animal Model of|Trimellitic Anhydride-Induced Lung Injury. J Allergy Clin|Immunol, 80(2): 223-229.
Method: other: Directive 84/449/EEC, B.4 "Acute toxicity (skin irritation)"
Ullmann, A21:159, cited in: SRC PhysProp Database, December|2001.
Toxicity to microorganisms, IUC4#48/Ch.4.4
NTP: Final Report on the Reproductive Toxcity of Caffeine|(CAS No. 58-08-2) Administered by Gavage to Sprague-Dawley|Rats, RACB94006, NTIS PB96-211743, (July 1996).
Method: other: NTP Reproductive Assessment by Continuous Breeding (RACB)
Toxicity to reproduction, IUC4#10/Ch.5.8.1
Streptomyces coelicolor, resistance to streptomycin
Bayer Chemicals (2004). Hydrolysis of phosphorus|trichloride. Unpublished study.
Barale R, Presciuttini S, Rossi AM (1979). Schizosaccharomyces pombe - mutazione genica in avanti. Mutagenesi Ambientale: Metodiche di Analisi. Vol. 1 (Test in Vitro; Magni G.M, Editor), Chapter 10, 105-121.
BASF AG (2005). Safety data sheet according to 91/155/EEC.|FORMIC ACID 98%, last update 04 Feb 2005.
Method: other: initiation-promotion liver foci assay (Leonard et al., 1983)
Report to National Toxicology Program, Assessment of Contact|Hypersensitivity to Butyl Acrylate in Femal B6C3F1 Mice.,|Protocol BAC-3-1-TO (Imm95005).
Bayer AG, unpublished data, 23.11.1972, cited in Bayer base|data set, last update 19.08.1994
Carlton, B. D., Barlett, P., Basaran, A., Colling, K., Osis,|I., Smith, M. K. (1986). Reproductive effects of alternative|disinfectants. Env. Health Perspectives, 69, 237-241
Wolkowski-Tyl R, Chin TY (1982) Effects of selected |therapeutic agents on urolithiasis induced by|terephthalic acid in the male weanling Fischer 344 rat.|Fundam Appl Toxicol 3(6), 552-8
Dill B, Heiker FR and Kirschning A (2003). Roempp Online,|Version 2.0, Georg Thieme Verlag, Stuttgart
BASF AG, Department of Toxicolgy, unpublished studies|(78/623), 23 Jan. 1979
Acute toxicity: inhalation, IUC4#45/Ch.5.1.2
Kuroda, Y. et al., Prog. Mutat. Res. 5, 537-542 (1985)
Natarajan, A.T. et al., Prog. Mutat. Res. 5, 433-437 (1985)
Method: other: a 1 % and a 2 % Traganth-emulsion was used, determination of signs of intoxication and gross autopsy (no further information)
Short-term toxicity to aquatic invertebrates, IUC4#80/Ch.4.2
Dow Corning Corporation Internal Report Number|1982-I0065-1167-19
Grigg, G.W.: J. Gen. Microbiol. 70 (2), 221-230 (1972);|cited in: RIFM database, location no. 11985
Magnusson, B. and Kligman, A.M.: J. Investigative|Dermatology 52, 268-276 (1969), No information
EPA OPPTS 870.5450 (Rodent Dominant Lethal Assay)
Ellis, M.M. (1937) Detection and Measurement of Stream|Pollution. In: Bull Bur Fish No 22, US Dep Commerce,|Washington, DC: 365-437; Reference Number: 916
Emtestam L and Forsbeck M (1985). Occupational|photosensitivity to dinitrotoluene. Photodermatology 2,|120-121.
Method: other: Standard photo-patch test procedure of the Scandinavian Photodermatitis Research Group (Contact Dermatitis, 155-158, 1982)
Degussa AG, DIN-Sicherheitsdatenblatt Extrusil v. 03.11.92
RCC Ltd. (2008) 3-Mercaptopropionic Acid: Toxicity |to Pseudokirchneriella subcapitata (Formerly |Selenastrum capricornutum) in a 72-Hour Algal Growth |Inhibition Test. Study Number B57892.
Deutsche Gewässerkundliche Mitteilungen 3, July 1983
Method: other: Official Journal 21 April 1971 / 05 June 1973
Lebertz, H. 1991b. Study on the toxicity of trimellitic|anhydride towards bacteria. Final Report. Battelle Europe|Study-No.: BE-EA-128-91-01-BHT-01.
Salmonella typhimurium TA 97, TA 98, TA 100, TA 104
Bayer Industry Services (2004c). Biodegradation of 1,4-Dichloro-2-butene. Unpublished Report, No. 1326 A/04 C.
EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test)
Dagaut P (1989). Kinetics of oxygen-containing organic|compounds with hydroxyl radicals in the gas phase: a review|for modelling combustion and atmospheric chemistry. Journal|de chimie physique 86(3), 595-621.
Kallos, G.J, Tou, J.C., Malczewski, R.M., and W.F. Boley|(1991) Stability Studies of Alkoxysilanes in Aqueous Media.|American Industrial Hygiene Association Journal, Vol. 52,|No. 7, pages 259-262 (as cited in MEDILINE TOXICOLOGY SUBSET|in BiblioLine, 2006)
Wong, P.T.S., Y.K. Chau, O. Kramar, and G.A. Bengert. 1982. Structure-toxicity relationship of tin compounds on algae. Can. J. Fish. Aquat. Sci. 39:483-488.
Chemicals Evaluation and Research Institute (CERI). (2001).|Report of Boiling Point Measurement of MMB, Report Number|81945. Unpublished Report.
De Flora S, Zanacchi P, Camoirano A, Bennicelli A, Badolati|GS (1984) Genotoxic activity and potency of 135 compounds in|the Ames reversion test and in a bacterial DNA-repair test.|Mutat Res 133: 161-198
Ullmann L (1980a). Report on skin irritation in the rabbit|after single application of FAT 65'023/K. Final report No.|791953, March 6, 1980; Exp. Toxicology GU 2.1, Ciba-Geigy|Ltd., Sisseln, Switzerland.
RCC (2000): Micronucleus assay in bone marrow cells of the mouse with Benzoguanamine, RCC-CCR Project 658000, July 17.2000
IRDC (1976) Acute Inhalation Toxicity in the Albino Rat.|International Research and Development Corporation (IRDC).|Study #: 378-001. Study Date: July 15, 1976.
Method: other: Federal Hazardous Substances Act, Chapter II, Title 16 CFR; pre-dates OECD.
Spindle, A. and Wu, K.:Teratology 32, 213-218 (1985);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Akzo Chemicals International BV (1992) In vivo assessment of|the clastogenic activity of N-(2-aminoethyl)-piperazine in|cultured human lymphocytes. Unpublished report number LSR|91/AKL148/1113.
Crebelli R. et al (1984), Mutation Research, 138, 33-38.
Amoco Corporation (1990) Abbreviated Primary Eye Irritation|Study of Terephthalic Acid in Rabbits. Conducted by IIT|Research Institute. IITRI Study #1555
Obe, G. And Ristow, H. (1977). "Acetaldehyde, but not|Ethanol, Induces Sister Chromatid Exchanges in Chinese|Hamster Cells in vitro." Mutat. Res. 56:211-213.
Lide DR (1992). CRC Handbook of Chemistry and Physics 72th|ed. CRC Press Inc, Boca Raton, 3-401.
Solubility in organic solvents / fat solubility, IUC4#15/Ch.2.6.1
Genetic toxicity in vitro, IUC4#179/Ch.5.5
Fontignie-Houbrechts, N.: Mutat. Res. 88, 109-114 (1981), No information
Genetic toxicity in vivo, IUC4#67/Ch.5.6
Govan, A.D.T. and Parkes, J. (1949) Acute experimental|calcium chloride acidosis. Br. J. Exp. Pathol., 30,105-114.
Clariant GmbH (1999): Calculation of water solubility from|Log Kow, SRC WSKOW v1.33
Cited as NTP, 1992 in http://cameochemicals.noaa.gov/chemical/20113
Repeated dose toxicity: dermal, IUC4#50/Ch.5.4
Chemicals Evaluation and Research Institute (CERI), Japan|(2002), Report number 43780, Unpublished data.
Koeck, M. & Schlee, D. (1981): Effect of sulfite on adenine|nucleotides of the green alga, Trebouxia. Phytochemistry|20(9), 2089-2092
Method: other: Effects on nucleotide content
Salem, H. and Cullumbine, H.: Toxicol. Appl. Pharmacol. 2,|183-187 (1960)
Method: other: according to Salem, H.: Dissertation, Univ. of Toronto, Canada (1958)
Hüls AG (1992b). Eigenschaften und Handling VESTAMIN|IPD/TMD. Information sheet 43.01.065/05.92/gu.
Ono Y, Somiya I, Kawaguchi T (1992) Genotoxic evaluation on|aromatic organochlorine compounds by using umu test. Water|Sci Technol 26: 61 - 69
Method: other: determination of ß-galacdosidase activity after a incubation time of 4 hours
Lee, H.K. et al.: Toxicol. Appl. Pharmacol. 75, 147-155|(1984), No information
IPCS Environ. Health Crit. 89 (1989), No information
Gross J. (1974) The effects of prolonged feeding of|terephthalic acid (TPA) to rats. Project FG-IS-175.|Submitted to US Dept. of Agriculture, Agriculture Research|Service, Washington D.C.
Flick, EW. (Ed.). 1991. Industrial Solvents Handbook 4 th ed. Noyes Data Corporation., Park Ridge, NJ.
CRC Handbook of Chemistry and Physics, 84th editon, CRC Press, 2004.
Dannenfelser R and Yalkowsky SH (1989). Database for Aqueous|Solubility of Nonelectrolytes. Computer Applications in the|Biosciences 5, 235-236
Hohensee, F., Faserforsch. 1, 299 (1951), zitiert nach:|Henschler, D. (Hrsg.), Gesundheitsschaedliche|Arbeitsstoffe. Toxikologisch-arbeitsmedizinische Begruendung|von MAK-Werten: Caprolactam (1975), 1.-17. Lfg., Verlag|Chemie (1991)
FMC Corp. data, TSCA 8d submission 86860000116 (1976)|cited in Chem. Reg. Reporter 11-13-87, 1244-1322 (1987)
Lu G-H, Yuan X, and Zhao Y-H (2001). QSAR study on the|toxicity of substituted benzenes to the algae (Scenedesmus|obliquus). Chemosphere 44, 437-440.
Nippon Petrochemicals Co., Ltd. (2003). Material Safety Data|Sheet on SAS-296.
CIBA-GEIGY, Ltd. 1974. Acute Oral LD50 of TK 11692 in the Rat. Project No.: Siss 3985. 10.6.1974.
Method: other: not reported (OECD 401 compliant)
Fregert S (1977). Personal communication. Cited in:|Lachapelle JM, Tennstedt D and Dumont-Fruytier M (1978).|Occupational allergic contact dermatitis to isophorone|diamine (IPD) used as an epoxy resin hardener. Contact|Dermatitis 4, 109-112.
Vos, H. L.: De Themische Stabiliteit Van Enige WHO|Smeltpunts Referentiestoffen Bij Het Smeltpunt, Pharm.|Weekblad 104, 619-629(1969)
Price, K.S. Waggy, G.T. and Conway, R.A.
Goldblatt M.W. et al: Brit. J. Ind. Med., 11,1-10, (1954)
Acute toxicity: dermal, IUC4#21/Ch.5.1.3
Sakuratani Y, Yamada J, Kasai K, Noguchi Y and Nishihara T (2005). External validation of the biodegradability prediction model CATABOL using data sets of existing and new chemicals under the Japanese Chemical Substances Control Law. SAR and QSAR in Environmental Research Vol. 16, no. 5, pp. 403-431.
Mikami, N. et al., Chemosphere 5, 305-310 (1979)
Method: other: comparable to later OECD Guideline 304 A "Inherent biodegradability in soil", 1981
BASF AG, Dept. Toxicology, unpublished data on the oral|toxicity of Glyecine A in rats after administration by|gavage|for 4 weeks, Report Project No.: 21C0811/89094, 14.May 1993
Method: other: OECD Guide-line 407, 1981
Randall TL and Knopp PV (1980). Detoxification of specific|organic substances by wet oxidation. J.Water Pollut.Control|Fed. 52(8), 2117-2130.
Method: other: Methods for Acute Toxicity Tests with Fish, Macroinvertebrates and Amphibians (EPA-660/3-75-009) 1975
Huntingdon Research Centre Ltd. (1988) Delayed contact|hypersensitivity in the guinea pig with|Isobutyltriethoxysilane. Report 8872D/DNN 17/SS.|Degussa-Huls AG-Nr.: 88-0303-FGT February 19, 1988
Hazelton Laboratories America, Inc. 1976. LC50 of Dibutyltin Dichloride in Rats. Final Report. 09.02.1976.
Norris, J.M. (1971) Eye and skin irritation properties of|LIQUIDOW liquid calcium chloride. Unpublished Dow Chemical|Company report.
Gagnaire, F., Azim, S., Bonnet, P., Hecht, G. and Hery, M.|(1994): Comparison of the sensory irritation response in|mice to chlorine and nitrogen trichloride. J Appl Toxicol,|14, 405-409.
Lyman, W.J., Reehl, W.J., Rosenblatt, D.H. (1983). Handbook|of chemical property estimation methods. McGraw-Hill, New|York. p. 5-4.
Method: other: calculated based on using logPow
Spruit, W.E.T. and R. Schilt. 2003. Trichloromethylstannane [CASRN 993-16-8]: Determination of the water solubility and partition coefficient of Trichloromethylstannane. Report PML 2003-C120. TNO Prins Maurits Laboratory, 2280AA Rijswijk, The Netherlands, March 2003.
BASF AG, Department of Toxicology, unpublished data on the|Maximization Test for the sensitizing potential of Glyezin A|in guinea pigs, Report No.: 30H0811/892373, 02. April 1991
BASF AG (1989). Department of Ecology, report No.|2/1122/88, 17 Nov 1989, unpublished.
Method: other: German Industrial Standard DIN 38412, Part 9
CRC Handbook of Chemicstry and Physics, 84th Edition. CRC Press (2003).
Method: other: in analogy with the OECD 202 proposal 1979
Long-term toxicity to aquatic invertebrates, IUC4#20/Ch.4.5.2
BASF AG, Department of Ecology, unpublished study, report|06.12.1984
BOD5 Method: other: BOD-test according to DIN 38409/51
Method: other: German Industrial Standard DIN 38 412, Part 15
Salmonella typhimurium TA98, TA100, TA1535, TA1537;
Schering AG. 1999. Experimentelle Toxikologie. Reproduction and chronic immobilization study for dioctyltin dichloride (ZK 21979) in Daphnia magna (21-d exposure). Research Report No. IC11. Berlin, Germany. 10 November 1999.
Gulati D.K. et al: Environm. Molec. Mutag. 13, 133-193,|(1989)
Method: other: according Galloway et al. 1985; Env. Mut. 7, 1-51
Mount, D.R., Gulley, D.D., Hockett, J.R., Garrison, T.D. and|Evans, J.M. (1997) Statistical models to predict the|toxicity of major ions to Ceriodaphnia dubia, Daphnia magna|and Pimephales promelas (fathead minnows). Env. Toxicol.|Chem., 16(10), 2009-2019.
CITI, Japan: Report No. K-131, Chemicals Inspection and|Testing Institute, (1982) unpublished data
Method: other: equivalent of OECD TG 305C
Geiger, D.L. et al., Acute toxicities of organic chemicals|to fathead minnows (Pimephales promelas), Vol. 2,|University of Wisconsin, 139-140 (1985)
Lewis, F.M. et al. (1995), Contact sensitivity to food|additives can cause oral and perioral symptoms, Contact|Dermatitis 33,|429-430
BASF AG, Department of Product Safety, Laboratory of|Ecology, Bacterial oxygen consumption test:|6-methylhept-5-en-2-one, unpublished summary-reprint of a|test report, 10/0905/88, 11 Aug. 1988
Method: other: oxygen consumption inhibition test according to Robra
Bus, J.S., Wolkowski-Tyl, R., and Barrow, C.S.: Teratology. |21(2): 32A. [Abstract] (1980).
Florin I et al. (1980): Screening of Tobacco Smoke|Constituents for Mutagenicity using the Ames Test.|Toxicology 18, 219-232
Method: other: spot test according to Ames, Mut. Res. 31, 347 (1975)
Kempermann T, Redetzky W, Engels HW (1987) Weitere|Untersuchung zu Langzeiteffekten von Alterungsschutzmitteln.|Kautschuk Gummi Kunstst 40: 1168 - 1176
Method: other: according to Ames, B.N. et al.: Mutat. Res. 31, 347-364
Method: other: according to Clive, D. and Spector, J.F.S.: Mutat. Res. 31, 17-29
Genetic toxicity in vitro, IUC4#104/Ch.5.5
Aldrich (1988). The Aldrich catalog/Handbook for Fine Chemicals. Aldrich Chemical Company, Inc., Milwaukee, WI, p.368.
Underhill F.P. (1920), cited in Environmental Health|Criteria 21, WHO (1982)
Acute toxicity: inhalation, IUC4#25/Ch.5.1.2
Salmonella typhimurium strains (not specified), Escherichia coli WP2uvrA
Slott VL and Hales BF (1985) Teratogenicity and|Embryolethality of Acrolein and Structurally Related|Compounds in Rats, Teratology 32, 65-72
Smyth HF and Carpenter CP (1948). Further Experience with|the Range Finding Test in the Industrial Toxicology|Laboratory, Journal of Industrial Hygiene and Toxicology 30,|63-68
Harada T et al., Bulletin Tech. Service of IB fertilisers|2-4, No. 11 (the Mitsubishi Chem. Ind. Ltd.), 1963. Cited|in: Hamamoto M: Isobutylidene Diurea as a slow acting|nitrogen fertiliser and the studies in this field in Japan,|The Fertiliser Society, No. 40, 1-77 (1966)
Bacillus subtilis H17 (arg-, trp-, recE+) and M45 (arg-, trp-, recE-)
Bayer AG (1991) 3,4-Dichlornitrobenzol rein krist.|Untersuchungen auf hautsensibilisierende Wirkung bei|Kaninchen (unpublished report no. 20721 [study T 7040193]).|Bayer AG, Wuppertal
Method: other: OECD Guide-line 406 , see additional freetext ME
Reported in TOXALL-Data Bank from Bogdanov M.V. et al.|(1980). Gig. Sanit., (6):76-78.
Genetic toxicity in vivo, IUC4#64/Ch.5.6
Method: other (calculated): with MPBPWIN, v.1.40
BG Chemie, Merkblatt M 010, 03/1991, Jedermann-Verlag|Heidelberg, 1991, No information
Capuzzo, J.M. (1979); The effect of temperature on the|toxicity of chlorinated cooling waters to marine animals : a|preliminary review; Mar. Poll. Bull, 10, 45-47.
Short-term toxicity to aquatic invertebrates, IUC4#42/Ch.4.2
Repeated dose toxicity: dermal, IUC4#28/Ch.5.4
Method: other: no further details given (pre-test for subchronic study)
BASF AG, Labor Oekologie; unveroeffentlichte Unter-|suchung, (Ber.v.07.01.87)
Method: other: BODx-determination, DEV H5 DIN 38409, Teil 51, Deutsche Einheitsverfahren zur Wasser-, Abwasser- und Schlammuntersuchung, Bestimmung des biochemischen Sauerstoffbedarfs
Demnati, R., Fraser, R., Ghezzo, H., Martin, J.G., Plaa, G.|Malo, J.L. (1998): Time-course of functional and|pathological changes after a single high acute inhalation of|chlorine in rats. Eur Respir J, 11, 922-928.
Schreiber G (1980b) Bericht ueber die Pruefung von|p-Nitrochlorbenzol auf Schleimhautreizwirkung.|Fraunhofer-Institut für Toxikologie und Aerosolforschung,|March 5, 1980 (at the request of Bayer AG)
Method: other: according to: Code of Federal Regulations, Title 16, Section 1500.42 , see also freetext ME
Probst GS et al. (1981): Chemically-Induced Unscheduled DNA|Synthesis in Primary Rat Hepatocyte Cultures: A Comparison|with Bacterial Mutagenicity Using 218 Compounds. Environm|Mutagen 3, 11-32
Method: other: Ames-test with the modification described by McMahon, 1979, Cancer Res 39, 682-693
Yazdani, M. et al.: Dev. Pharmacol. Ther. 14, 52-61 (1990)
Developmental toxicity / teratogenicity, IUC4#16/Ch.5.8.2
ATSDR (Agency for Toxic Substances and Disease Registry)|Toxicological Profile for CHLOROMETHANE. ATSDR/TP-90-07|(1990).
Solomon H.M. et al. (1991). Fundam. Appl. Toxicol.,|16:414-422.
Roempp (2003). Roempp Lexikon Chemie, 10th edition, -|electronic version 2.0, Georg Thieme Verlag Stuttgart/New|York.
Zeiss, C.R., Mitchell, J.H., Van Peenen, P.F., et al. 1992.| A clinical and immunologic study of employees in a facility|manufacturing trimellitic anhydride. Allergy Proc. Vol. 13|(4): 193-198.
N.Yoshimi et al. The genotoxicity of a variety of aniline|derivatives in a DNA repair test with primary rat|hepatocytes, Mutation Research, 206 (1988) p183-191
Method: other: method of Williams et al.(1982)
Xie, D.Y. et al., Weisheng Dulixue Zazhi, 6(2), 91-93 (1992)
Method: other (calculated): AOPWin version 1.89
Nishikawa, A. et al.: Fd. Chem. Toxic. 33 (1), 21-26 (1995)
Kligman A (1966) The identification of contact allergens by human assay. III. The maximization test: a procedure for screening and rating contact sensitizers. Journal of Investigative Dermatology 47:393-409.
Chemical Handbook,Japan, 2nd edition, 1975
Henninghausen, G., P. Lange, and J. Merkord. 1980. The relationship between the alkyl chain of dialkyltin compounds and their effects on thymus and bile ducts in mice. Arch Toxicol. Suppl. 4:175-178.
Huels AG (1994), unpublished report RW 038. Bestimmung der|Auswirkungen von Malonsäurediethylester auf Regenwürmer|(Eisenia foetida foetida) (Toxizitätstest für Regenwürmer|nach 88/302 EWG)|Degussa AG-Reg-Nr.: 94-0234-DGO
Method: other: Directive 88/302/EEC, 1988
Toxicity to soil macroorganisms except arthropods, IUC4#2/Ch.4.6.3
Bringmann,G., Z. Wasser- und Abwasser-Forschung 11(6),|210-215, 1978, No information
Jaffe M (1874) Über das Verhalten des Nitrotoluols im|thierischen Organismus. Ber dt chem Ges 7: 1673-1679
Huels AG (1989). unpublished report No. 11/221. Acute Eye|Irritation Test in the Rabbit. Degussa AG-Reg-Nr.:|89-0276-DGT.
Method: other: according to U.S.A. Environmental Protection Agency Guidelines
Springborn Smithers Laboratories (2004) Trimethoxysilane -|Acute Toxicity to Daphnids (Daphnia magna) Under Static|Conditions. Wareham, MA. Report No. 12023.6144.
Chun, J.S. and C.L. Wagner. 1993. Organofunctional Silane|A-1120: Nine-Day Repeated Cutaneous Dose Toxicity Study in|Fischer 344 Rats. Bushy Run Research Center, Laboratory|Project ID 91U0024, August 17, 1993.
Simmon VF (1979) In Vitro Mutagenicity Assays of Chemical|Carcinogens and Related Compounds with Salmonella|typhimurium. J Natl Cancer Inst 62: 893-899
Cascieri, T.; Fletcher, M. J.; Weinberg, M. S.; The|Toxicologist vol. 1, 149 (1981).
Method: other: topical application in acetone
St-Jean, S.D., E. Pelletier, and S.C. Courtenay. 2002. Very low levels of waterborne butyltins modulate hemocyte function in the blue mussel Mytilus edulis. Mar. Ecol. Prog. Ser. 236:155-161.
Moreno, O.M.: Report to RIFM (1980), quoted in: Ford, R.A.|et al.: Fd. Chem. Toxic. 26, 273-416 (1988)
Method: other: Draize Test according Fed. Reg, 38, No,187, §1500.41, p. 27029 (1973/sept./ 27) see also freetext ME
Matthews EJ, DelBalzo T Rundell JO (1985) Assays for|morphological transformation and ouabain resistance of|Balb/c-3T3 cells in culture. Prog Mut Res 5: 639-650
Lide DR (1992). CRC Handbook of Chemistry and Physics 72th ed. CRC Press Inc, Boca Raton, p. 3-142.
FMC Corporation, FMC shock treatment: skin sensitization|study in guinea pigs, Study no. I90-1113, 1990.
Mitsubishi Chemical Safety Institute Ltd. (2002). Acute|toxicity of sodium gluconate with Medaka (Oryzias|latipes). Study number A010387. Study sponsored by|Fujisawa Pharmaceutical Co., Ltd.
Solvias AG (1999). Internal report No. S 129 25: Acute|toxicity of C.I. Fluorescent Brightener 28/113 (90 %|Na-salt) to the earthworm, Eisenia fetida, 1999-11-12.
methacrylic acid, monoester with propane-1,2-diol
Ito, N. et al., CRC Critical Rev. Toxicol. 19, 385-415|(1989)
ToxiGenics (1981a). Primary Eye Irritation Study in Rabbits|of X-19381 Aminosilane, Study 410-0745; October 21. 1981.
Method: other: protocol in Galloway Environm. Mol. Mutagen. 10 [Suppl 10],1-175, 1987; solvent control, positive control, harvest time: 14 hours
Method: other: different doses, gastric administration as 3 % solution; no further details
Clapp, N.K. et al. (1978): J. Natl. Cancer Inst. 61, |177 - 182
Tanaka, H. and Nakazawa: Biologia Neotat. 57 (2), 133-139|(1990);|cited in: RIFM database, location no. 14586
Neal SB, Probst GS (1983): Chemically-induced|sister-chromatid exchange in vivo in bone marrow of Chinese|Hamsters. Mut Res 113: 33-43
Method: other: BUdR tablet method according Allen et al., 1977, Cytogenet.Cell Genet. 18, 231
Degussa AG (2003), unpublished Report. In vitro assessment|of the clastogenic activity of Dimethyl malonate in cultured|human peripheral lymphocytes. Degussa AG REG. No.|2003-0150-DGM.
BASF AG, Department of Product Safety, Laboratory of|Ecology/Toxicology, Untersuchungsbericht Prüfung auf|Ökotoxizität: Hemmung der Algen-Zellvermehrung nach DIN|38412 L9, unpublished study, 01/89/1485, 6 Dec 1989
Method: other: algal growth inhibition test according to German Industrial Standard DIN 38412, part 9
Tsai Y. L.; Tuovinen O. H.; FEMS Microbiology Letters, vol.|28, 11 - 14 (1985).
Method: other: washed cell suspension; Tsai, Tuovinen
Elia M.C. et al., Environm. Molec. Mutagen. 24, 181-191|(1994)
Method: other: in vitro alkaline elution assay
Yoshioka Y, Ose Y, Sato T (1986) Testing and evaluation of|chemical toxicity on Tubifex. Eisei-Kagaku 32: 308 - 311
Mangat, Dutt, Malik (1988) Proc. Indian Acad. Sci. (Plant Sci.) 98(1):61-66.
Cincinnati Milacron Chemicals, Inc. 1973. Sub-chronic (90-day) toxicity study with monomethyltin tris-isooctyl-mercaptoacetate in rats. Rapport Nr. R4062. Centraal Instituut voor Voedingsonderzoek (TNO). April 1973.
Method: other: similar to OECD Guideline 408
Budavari S, O'Neil MJ, Smith A et al. (1989). The Merck Index: an encyclopedia of chemicals, drugs and biologicals, 11th edition. Whitehouse Station, NJ, Merck and Co. Inc.
USEPA (2000) SAR Model WSKOWWIN® (version 1.40).
BASF AG: Department of Toxicology, unpublished study, Report on the study of percutanous resorption toxicity of Isobutyl acrylate, (XII/248), July 12, 1963
McCormick, Feeherry, Levinson (1976): Appl. Environ. |Microbiol. 31, 949-958
Biodegradation in water: screening tests, IUC4#51/Ch.3.5
CERI (1994) Chemicals Evaluation and Research Institute|(Kurume, Japan) Test 21203
Müller D, Fritz H, Langauer M and Strasser FF.|VII/10 Nucleus anomaly test and chromosomal analysis of bone|marrow cells of the Chinese hamster and dominant lethal test|in male mice after treatment with fluorescent whitening|agents. in: Anliker R and Müller G, guest eds., Fluorescent|whitening agents. EQS Environmental Quality and Safety,|Suppl. Vol. IV, 247-263, Georg Thieme Verlag, Stuttgart,|1975.
Hetherington, H. C. and Brahm, J. M.: Preparation of|Dicyanodiamide from Calcium Cyanamide, Ind. Eng. Chem. 15,|1060-1063(1923)
Leo AJ and Weininger D (1985) cited in: Russom CL et al.:|Acute Toxicity and Behavioral Effects of Acrylates and|Methacrylates to Juvenile Fathead Minnows. Bull. Environ.|Contam. Toxicol. 41, 589-596, (1988)
Ishikawa T, Ose Y, Sato T, and Inoue Z (1978). Waste water|treatment of night soil. VIII. Removal of volatile fatty|acids using bacteria isolated from an aerobic treatment|plant for undiluted night soil. Eisei Kagaku 24(5):226-30.|Abstract: CA:09026209529G
Method: other: application to the back, dose: no data, exposure time: 1 min., 5 min., 15 min. and 20 hours; reading: 24 hours and day 8 post exposure
Ato-Chimie (1978) Acide omega amino undecanoïque, Test de|tolérance chez le lapin: indice d'irritation occulaire,|indice d'irritation cutanée primaire. IFREB report no.|801260, 24 janvier 1978.
BASF AG, Department of Toxicology, unpublished results,|Proj. No. 13I0548/877054, 10 Feb. 1988
Mattice et al. (1981) Water Research, 15, 923-927
Toxicity to microorganisms, IUC4#70/Ch.4.4
Johansson, S.L.: Int. J. Cancer 27, 521-529 (1981);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
David, R.M., T. R. Tyler, R.E. Ouellette, W. D. Faber, and|M. I. Banton. Evaluation of Subchronic Toxicity of n-Butyl|Acetate Vapor. Accepted for publication, Food Chemical|Toxicology, 39: 877-886.
Product Investigations Inc, Shelanski MV (1976) Evaluation|of potential hazards by skin contact. Study report 76-008,|unpublished study of Monsanto Chemical Co. NTIS/OTS 555167,|EPA/OTS document # 88-920008669 (1992)
Scott, C.C. and Chen, K.K.: J. Pharmacol. Exp. Ther. 82,|87-97 (1944);|cited in: Schlede, E. et al.: Arch. Toxicol. 66, 455-470|(1992)
Sacks, L.E. and Mihara, K.: Mutat. Res. 117, 55-65 (1983)
Method: other: according to Sacks, L.E. and MacGregor, J.T.: Mutat. Res. 95, 191-202
INERIS (1992); Essai de determination de la toxicite aigue|d'une eau de Javel LaCroix a 12 degree C 5 chloro vis a vis|de Daphnia daphnia. Demande par Colgate Palmolive : 21 p.
Hazleton Laboratories America, Inc. (1983) Salmonella|typhimurium Mammalian Microsome Plate Incorporation Assay|with Methyl Mercaptoprionate. Project No. 652-145.
Method: other: similar to OECD 471 and OPPTS 870.5100
CIBA-GEIGY, Ltd. 1972. Acute oral LD50 of TK 11285 in the rat. Project No. Siss 2501. 14.12.1972.
Salmonella typhimurium TA1535, TA1537, TA1538, TA100 and TA98.
CIT (1994) Skin sensitization test in guinea pigs (Maximization method of Magnusson, B. and Kligman, A.M.) - Isooctylthioglycolate), Centre International de Toxicologie, Report no. 10272 TSG, February 1994.
Acute toxicity: inhalation, IUC4#27/Ch.5.1.2
MOE Japan (1999). Ministry of Environment, Toxicity study of|choline chloride on the freshwater alga Pseudokirchnerialla|subcapitata, unpublished study, No. 1998-13
Acute toxicity: dermal, IUC4#27/Ch.5.1.3
Rush, R.E. 1993. Primary skin irritation study in rabbits with [mono/di] methyltin chlorides solution. Springborn Laboratories, Inc. SLS Study No. 3255.13. July 21, 1993.
Fukuda K, Matsushita H Takemoto K (1978) Carcinogenicity of|orally administered benzotrichloride. In: Proceedings of the|52nd Annual Meeting of the Japanese Industrial Health|Association pp. 516 - 517, cited in: IARC (International|Agency for Research on Cancer) (1982) Monographs on the|evaluation of the carcinogenic risk of chemicals to human|29: 73 - 82|and: TSCA 8e Submission 8EHQ-0980-0360 Document No.|86-8000116, Washington, DC: Office of Toxic Substances, U.S.|Environmental Protection Agency
Method: other: carcinogenicity after repeated (28 days) oral treatment
Cannon Laboratories (1978) The subchronic oral LD50 of|Cincinnati Milacron sample 1185-115 in day-old Leghorn|chickens, Report 8E-2526, December 1978.
TNO, An investigation into the possible induction of point|mutations at the HGPRT locus of V79 Chinese Hamster lung|cells by o-chloronitrobenzene, Report No. R. 88/114b, 1989|(at the request of BG Chemie)
Method: other: OECD Guide-line 476, rat liver S9-mix (induced), toxicity test prior to testing, exposure duration 5 hours, positive controls (EMS, DMN)
Covance Laboratories (2004) Resorcinol (A011): Induction of micronuclei in cultured human peripheral blood lymphocytes. Report number 413/68-D6172. Sponsor L'OREAL.
Christophliemk P (1985). Herstellung, Struktur und Chemie|technisch wichtiger Alkalisilicate. Glastech. Ber. 58,|308-314.
BASF AG (1977). Department of Ecology, report from 25 Jan|1977 (test start), unpublished.
BIOPHARM: unpubl. report No. 022 TOX94, June 02, 1995|(sponsored by BG Chemie, Germany)
RCC Cytotest Cell Research GmbH (RCC-CCR) (2007) In vitro|Chromosome Aberration Test in Chinese Hamster V79 Cells with|Methyl-3-Mercaptopropionate (CASN 2935-90-2). Report Number|A75767
Bringmann and Kuehn, Testing of substances for their|toxicity threshold: Model organisms Microcystis|(Diplocystis) aeruginosa and Scenedesmus quadricauda, Mitt.|Internat. Verein. Limnol. 21: 275-284, 1978 (99)
Saccharomyces cerevisiae D6, DG1-M, D7, PV-2, PV-3, RM-52
BioReliance (2008) Vinyltris(methylethylketoximino)silane:|Bacterial Reverse Mutation Assay. Study No. AC04RZ.503.BTL
Genetic toxicity in vitro, IUC4#196/Ch.5.5
Boelhouwers EJ (2004). Determination of the water solubility of bis(4-chlorophenyl) sulfone according to the column elution method. Solvay Pharmaceuticals Int. Doc. No. 7811/0002/2004.
Boyer, I.J. 1989. Toxicity of dibutyltin, tributyltin, and other organotin compounds to humans and to experimental animals. Toxicology. 55:253-298.
Yaws CL (1999) Handbook of Thermodynamic and Physical Properties of Chemical Compounds.
Hazleton Washington (1992): "Mutagenicity Test on CT-516-92 in the Salmonella/Mammalian-Microsome-Mutation Assay (Ames Test)", final report (HWA Study No.: 15318-0-401), submitted to American Cyanamid Co., 12.08.1992; cited in BG Chemie (ed.):2-Methylpropanol-1, in: Toxikologische Bewertung, Ausgabe 01/97, BG Chemie, Heidelberg, pp. 3-40, (1997) as cited in IUCLID.
Method: other: according to Maron, D.M. and Ames, B. (1983) Mutat Res 113:173-215
BASF AG, Safety data sheet ISOBUTYL ACRYLATE, 11.10.2004
Jenner et al. (1964). Cited in Opdyke DLJ (1979). Monographs|on fragrance raw materials, Ionone, 444
GESTIS - Substance Database (Information system on hazardous substances of the Berufsgenossenschaften), 12.10.2005
Chanet, R. et al.: Mutat. Res. 33, 179-186 (1975), No information
Genetic toxicity in vitro, IUC4#149/Ch.5.5
Ward, T.J., J.P. Magazu, and R.L. Boeri. 1995. Acute toxicity of mixed methyltin chlorides to the earthworm, Eisenia foetida. T.R. Wilbury Laboratories, Inc. Study Number 860-MO. December 15, 1995.
Hoechst AG, department of toxicology: unpublished results,|report no. 83.0531;|cited in: EUROPEAN COMMISSION - European Chemicals Bureau|2000-02-11, No information
Alexander, M. and Lustigman, B.K., Effect of Chemical|Structure on Microbial Degradation of Substituted Benzenes,|J. Agr. Food Chem. 14, 410 - 413 (1966)
Khadzhieva E.D.: Hyg. Sanit (USSR) 34, 28-32, (1969)
Bruce, R.D.: Fund. Appl. Toxicol. 8, 97-100 (1987);|cited in: RIFM database, location no. 4656
Radian Report, 1988. Final Report for the Environmental Fate|Studies of Methyl Bromide. Conducted by Radian Corporation,|Austin, TX, for the Methyl Bromide Industry Panel of the|Chemical Manufacturers Association, Arlington, VA, Report|DCN: 88-266-040-03, RC No.: 266 -040-04-01.
Prosolenko NV and Vasilenko NM (1979): Gig Truda prof Zabol|23, p. 54 (in Russian) as cited in: BIBRA working group.|2-Hydroxy-3-Naphthoic Acid. Toxicity profile. BIBRA|International, 1999
Christopher HJ, Boardman GD, Freedman DL (2000). Aerobic|biological treatment of 2,4-dinitrotoluene in munitions|plant wastewater. Water Res. 34(5), 1595-1603.
Method: other: Degradation in batch reactors
BASF AG, 2003, Product Safety, SRC AOP v1.90, data|assessment, unpublished calculation, 4 Dec. 2003
Huntingdon Life Sciences Ltd. (2001). Tungsten carbide DS|100. Bacterial mutation assay. Unpublished Report No. SKC|032/004688, February 8, 2001.
Ministry of International Trade and Industry (MITI) (1992):|Biodegradation and bioaccumulation data of existing|chemicals based on the Chemical Substances Control Law|(CSCL), Japan. Chemicals Inspection and Testing Institute|(CITI) (ed.); Japan Chemical Industry Ecology - Toxicology|and Information Center 1-27, 2-33
Bayer AG (1999). Decrease of NCO-content in water - Desmodur I. Report No. N 99/0050/01 LEV (unpublished).
Lewis RJ Sr. (1996), Sax's Dangerous properties of industrial materials, Ninth edition: 2051.
M&T Chemicals Inc., TSCAT, OTS0200247, Doc I.D. 88-8400561,|Bio/dynamics Inc.: Project No. 81-7534 B, 15 Dec. 1982; 11 Oct. 1983
Zeyer, Kearney (1983): J. Agric. Food Chem. 31, 304-308
Method: other: Evaluation of degradation with a radiolabelled substrate, [14C]-Methode (Tracer analysis), evaluation of the release of CO2
Cultured Chinese hamster ovary (CHO-K1) cells
CIT (2004) In Vitro Mammalian Cell Gene Mutation Test in L5178Y TK+/- Mouse Lymphoma Cells. Study number 27065 MLY RCS, Evreux, France. Study sponsor: L'Oreal.
Genetic toxicity in vivo, IUC4#44/Ch.5.6
Method: other: effects on progeny (F1), see freetext ME)
De Groot WA (2006). The Acute Toxicity of DCDPS (4,4'-Dichlorodiphenyl sulfone) to Zebra fish (Brachydanio rerio). Solvay Pharmaceuticals Int. Doc. No. 7811/0046/2006.
Hommel G (1997). Handbuch der gefaehrlichen Gueter, 6.|Auflage, Merkblatt 358. Springer-Verlag, Berlin /|Heidelberg.
Allyl Alcohol Consortium (2004a). Growth Inhibition Test of|Allyl Alcohol with Pseudokirchneriella subcapitata.|Mitsubishi Chemical Safety Institute Ltd. Study No. A040193,|unpublished data.
CEC/IPCS (2002) International Chemical Safety Card|p-Nitrotoluol.|http://www.cdc.gov/niosh/ipcsngrm/ngrm0932.html
BASF AG (1989). Department of Ecology. Study performed at|Dr. U. Noack-Laboratory, BASF project No. 01/89/0733, 23 Oct|1989, unpublished.
Amoco Corporation (1975) Acute Oral Toxicity Study With|Terephthalic Acid in Rats. Conducted by Industrial Bio Test|Laboratories, Inc. IBT Study #601-06339
Repeated dose toxicity: oral, IUC4#44/Ch.5.4
Bayer AG (1976). Kimmerle G. Blankophor BBH (Farbsaeure).|Akute Inhalationstoxizitaet an Ratten. Study report No. 5898|dated 1976-02-11.
Skin irritation / corrosion, IUC4#100/Ch.5.2.1
FMC Corporation, Acute and 28-day subacute toxicity of|potassium persulfate, Study no. ICG/T-79-024, 1979.
BASF AG (1991). CZB/DG - E 100. pH-vlaues of NMP in water -|internal evaluation of pH - measurements conducted in 1990,|unpublished note, 25/26 Sep 1991.
Macht, D. I., Shohl, A. T.: J. Pharmac. exp. Ther. 16,|61-69 (1921)
BASF AG, Technical Information, n-Butylacrylat, 1990
Milvy P and Kay K: Mutagenicity of 19 Major Graphic Arts and|Printing Dyes (1978). J Toxicol Environm Health 4, 31-36.
BASF AG, Firmenschrift Caprolactam, Januar 1989
Davis MH and Coughlan J (1978) Response of entrained|plankton to low-level chlorination at a coastal power|station; Proc. 2nd Conf. on Water Chlorination; Environ;|impact health.
Toxicity to aquatic algae and cyanobacteria, IUC4#14/Ch.4.3
Method: other: Gaseous methyl bromide over culture media
Litton Bionetics Inc. (1979) Mutagenicity Evaluation of 3,4-Toluene Diamine in the Ames Salmonella/Microsome Plate Test, Final Report, EPA Document No. 878214425, Fiche No. OTS0206567. (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com)
Food and Agriculture Organization of the United Nations,|Report Series. 40,127, 67. In Lewis, R.T. (ed.). 1994. Sax's|Dangerous Properties of Industrial Materials. Eighth|Edition. New York: Van Nostrand Reinhold Company. Cited in|ACC (2003)
Pearson JG, Glennon JP, Barkley JJ, Highfill JW (1979). An|Approach to the Toxicological Evaluation of a Complex|Industrial Wastewater. ASTM Tech Pub (Aquatic Toxicology,|2nd Conference) 667, 284 - 301.
Method: other: EPA-660/3-75-009, "Methods for acute toxicity with fish, macroinvertebrates and amphibians", 1975
Haskell Laboratories, E.I. Dupont de Nemours and Company;|Health and Safety Study Report. (1978), EPA Document No.|877800204, Fiche No. OTS0200336, as cited in HSDB.
Method: other: in general conformance with OECD 471
Short-term toxicity to aquatic invertebrates, IUC4#39/Ch.4.2
Lewis Sr. RJ (1996). Sax's Dangerous Properties of|Industrial Materials, 9th Edition, Van Nostrand Reinhold,|New York, 156.
BASF AG (1988a). Analytical Laboratory, Bestimmung der|biologischen Abbaubarkeit im modifizierten|OECD-Screening-Test; unpublished study (320712). January 22,|1988 [in German].
Trama, F.B. (1954). The acute toxicity of some common salts|of sodium, potassium and calcium to the common bluegill|(Lepomis macrochirus Rafinesque). Proc. Academy of Natural|Sciences of Philadelphia 106:185-205.
BASF AG, Product Details N-(2-AMINOETHYL)ETHANOLAMINE, 19.10.2005
Method: other: according to Van Leeuwen et al. (1985)
Toxicity to aquatic algae and cyanobacteria, IUC4#150/Ch.4.3
Chemicals Evaluation and Research Institute (CERI). (2001).|Report of Vapour Pressure Measurement of MMB, Report Number|81946. Unpublished Report.
Crompton Corporation (2001) Material Safety Data Sheet. |Silquest A-187 silane. CAS No. 2530-83-8. 3/20/2001
MITI (1992). Biodegradation and Bioaccumulation Data of|Existing Chemicals Based on the CSCL Japan, Compiled under|the Supervision of Chemical Products Safety Division, Basic|Industries Bureau MITI, Ed. by CITI, October 1992.
Method: other: corresponding to OECD guideline 305 C
Method: other: according Fed.Reg.38, No.187, 1973: observation time: 24 hrs
Method: other: determination of vapour pressure; dynamic with argon
Method: other: plate and suspension test
Toxicity to terrestrial plants, IUC4#28/Ch.4.6.2
Method: other: similar to OECD Guide-line 471; protocol according to Haworth, et.al. (1983)
Tang, N.H., Blum, D.J.W., Nirmalakhandan. N., and Speece,|R.E.: QSAR parameters for toxicity of organicchemicals to|Nitrobacter. Journal of Environmental Engineering, 118 (1):|17-37 (1992).
Janssen, W.A.J. and Van den Berg, G. (1992), "The toxicity|of epsilon-caprolactone to the bacteria Pseudomonas putida"|Solvay Duphar Int. Doc. No. 56635/47/92
Method: other: ISO/TC 147/SC 5/WG 1 N 133
S. typhimurium TA 98, TA 100, TA 1535, TA 1537, Escherichia coli WP2 uvrA
Biodegradation in water and sediment: simulation tests, IUC4#5/Ch.3.5
Method: other: Younger Laboratories method
Cofrac ESSAIS (1997) Methyl 3-mercaptopropionate:|Determination of the biodegradability by the CO2 Evolution|Test (OECD TG 301B) Report number 9085/96/A.
Method: other (calculated): Expert judgement
Carpenter CP, Smyth HF, Pozzani UC (1949) The Assay of Acute|Vapor Toxicity, and the Grading and Interpretation of|Results on 96 Chemical Compounds, Journal of Industrial|Hygiene and Toxicology 31, 343-346
Bills, D. et al.: "Investigation in fish control. 73.|Formalin, its toxicity to nontarget aquatic organisms,|persistence and counteraction"; Washington DC, U.S.|Department of the Interior, Fish and Wildlife Service, 1-7,|(1977), No information
Short-term toxicity to fish, IUC4#91/Ch.4.1
Amoco Corporation (1970) Fifteen Week Oral Toxicity Study of|Terephthalic Acid - Albino Rats. Conducted by Toxicological|Evaluations. LSL Study#1358
Bayer AG: Thyssen J (1979). Dicyclohexylamin, Untersuchung|zur Haut- und Schleimhaut-vertraeglichkeit. Short report,|19.3.1979.
Method: other: application into the conjunctival sac of one rabbit eye (the other eye served as control), observation time: 7 d
Dow Corning Corporation Internal Report Number|1976-I0065-1167-30
Cerniglia et al. (1983): Arch. Microbiol. 136, 177-183
Steinhoff D, Lorke D, Hoffmann K, Dycka J and Artik N.|Chronische UV-Bestrahlung haarloser Mäuse bei gleichzeitiger|kutaner Applikation von Weisstönern. Pharma Report No. 7490,|May 3, 1978. Institute of Toxicology, Bayer AG, Wuppertal,|Germany.
NTP (1986) Annual Plan for Fiscal Year 1986, NTP-86-086: 72
Union Carbide Data Sheet (1971). Union Carbide Corp., 39 Old|Ridgebury Rd., Danbury, CT 06817.
Skin irritation / corrosion, IUC4#102/Ch.5.2.1
Zijlstra, J.A.: Mutat. Res. 181, 338 (1987); abstract no. 64, No information
Method: F34-06:(calculated), BCFWIN V 2.14
Rhodia Operations (2006). Isophorone diisocyanate exposure questionnaire (unpublished).
Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed.|Volumes 1-26: New York, NY. John Wiley and Sons, 1978-1984.
Jaber et al. EPA CONTRACT 68-03-2981, p209.
BASF AG: Department Toxicology (87/100), 08.09.1987
Method: other: method used closely followed OECD Guide-line 203
Nohmi T, Yoshikawa K, Nakadate M, Miyata R, Ishidate M Jr|(1984) Mutations in Salmonella typhimurium and inactivation|of Bacillus subtilis transforming DNA indurced by|phenylhydroxylamine dervatives. Mut Res 136: 159-168
Bayer AG (1990). Phytotoxicity of DNT. Unpublished Report|(No 174 A/90).
Method: other: Phytotoxicity Test on a monocotyledenous plant species (Avena sativa)
Price, K.S., G.T. Waggy, and R.A. Conway. 1974. Brine Shrimp Bioassay and Seawater BOD of Petrochemicals. J. Water Pollut. Contr. Fed. 46:63-77.
Method: other: BOD (Standard Methods for the Examination of Water and Wastewater. 1971. 13th Edi. American Public health Association, New York, NY)
Bausum HT, Mitchell WR, Major MA (1992). Biodegradation of|2,4- and 2,6-dinitrotoluene by freshwater microorganisms. J.|Environ. Sci. Health A27(3), 663-695.
Method: other: 14C tracing in batch degradation experiments
Smyth et al.: Am. Ind. Hyg. Ass. J. 30, 470 (1969)
Chemfinder Internet Database (2003) Data sheet for|alpha,alpha,alpha-Trichlorotoluene.|www.chemfinder.cambridgesoft.com
International Technical Information Institute (ITII) (1988)|Toxic and Hazardous Industrial Chemicals Safety Manual,|ITII, Tokyo, Japan, p. 101.
Novartis Services AG (1997). Internal report No. N 061 17:|Acute toxicity of C.I. Fluorescent Brightener 28/113 (22 %|Na-salt) to Green algae, 1997-02-20.
Newton, P.E. 1994a. An up-and-down acute inhalation toxicity|study of methyl bromide in the dog. Unpublished report from|Pharmaco-LSR Project number 93-6067.
Salmonella typhimurium TA 92, TA 98, TA 100, TA 1535, TA 1537, TA 1538
Institut FRESENIUS (1996) Report N° 96TE103762.|i-Octylthioglykolat. Pruefung der leichten biologischen|Abbaubarkeit von Produkten. (In german)
Mattson V.R., Arthur J.W. and Walbridge C.T. Acute toxicity|of selected organic compounds to fathead minnows. Duluth|(MN.) EPA Environ. Res. Lab., EPA-600/3-76-097, 1976.
Talley JW, Felt DR, Hansen LD, Spain JC, Pritchard H, Sewell|GW, Tiedje JM (2001) The Federal Integrated Biotreatment|Research Consortium (Flask to Field). In: Magar VS, von|Fahnestock FM, Leeson A. 6th|International In Situ and On-Site Bioremediation Symposium,|San Diego, CA, United States, June 4-7, 2001, Volume 7,|125-132. Battelle Press, Columbus, Ohio.
Hanausek, M., Z. Walaszek, A. Viaje, M. LaBate, E. Spears, D. Farrell, R. Henrich, A. Tveit, E. F. Walborg Jr and T.J.Slaga (2004) Exposure of mouse skin to organic peroxides: subchronic effects related to carcinogenic potential. Carcinogenesis: 25(3): 431-437.
Hradec J, (1988) The initiator tRNA acceptance assay as a|short-term test for carcinogens. 1. A standardized|procedure. Carcinogenesis 9: 837-842
Method: other: Hradec, J. (1988): Carcinogenesis 9, 837-842
Stack,V.T.Jr., Industrial and Engineering Chemistry 49,|913-917, (1957)
Epona Associates, LLC. 2006. IUCLID Data Set: Isooctyl Mercaptoacetate. CAS No. 25103-09-7. 30.05.2006.
Jensen, H.J. and Cohr, K.-H.: Mutat. Res. 113, 266 (1983);|abstract no. 73, No information
Method: other: in vivo gene mutations - mammals (somatic cells)
Genetic toxicity in vivo, IUC4#25/Ch.5.6
Anthracene oil, anthracene paste, anthracene fraction
Pella PA (1977). Measurement of the vapor pressures of TNT,|2,4-DNT, 2,6-DNT, and EGDN. J Chem Theromodyn 9, 301-305.
Method: P06-04:electron-capture gas-chromatographic method
Haworth, S. et al.: Environ. Mutagen. 5, (Suppl.1), 3-142|(1983)
WIL Research (2005) 2-ETHYLHEXYL MERCAPTOACETATE [CAS No.|7659-86-1]: A REPRODUCTION/DEVELOPMENTAL TOXICITY|SCREENING STUDY IN RATS
Degussa AG: Study on the acute toxicity towards fish of|"SIPERNAT 820 A (sodiumaluminiumsilicate)". Institut|Fresenius IF-98/29222-00; unpublished report: DEGUSSA AG -|US-IT-No. 98-0071-DGO, 1998
GESTIS (2006). Database (Gefahrstoffinformationssystem der|gewerblichen Berufsgenossenschaften). Available online at|http://biade.itrust.de/biade/lpext.dll?f=templates&fn=main-h|.tm, request of 20 Oct 2006.
Worne HE (1972). The activity of mutant microorganisms in|the biological treatment of industrial wastes. Aqua Sana,|Lentebeurs van Vlaanderen, 61-71. Gent.
Biodegradation in water: screening tests, IUC4#140/Ch.3.5
West, G.L. et al.: Neurobehav. Toxicol. Teratol. 8 (1),|29-43 (1986);|cited in: RIFM database, location no. 5941
Method: other: UBA-Verfahrensvorschlag "Hemmung der Zellvermehrung bei der Gruenalge Scenedesmus subspicatus" (EC10; EC50; 72 Stunden; statisches System) (01.01.1984)
FMC Corporation, Sodium persulfate: acute toxicity to the|freshwater green alga, Selenastrum capricornutum, under|static test conditions, Study no. I97-2228, 1998.
Adsorption / desorption, IUC4#10/Ch.3.3.1
Imaida, K. et al. (1988): Cancer Lett. 43, 167 - 172
Method: other: Liver, Forestomach and Bladder Carcinogenesis Promotion Assay
Lane AM, Phillips BJ, Anderson D (1985) Tests of the|induction of sister-chromatid exchanges in Chinese hamster|ovary cells in culture. Prog Mut Res 5: 451-455
Genetic toxicity in vitro, IUC4#125/Ch.5.5
Koopman, T.S.M. and Pot, T.E. (1986) Acute oral toxicity|study with calcium chloride 33% in male rabbits. Duphar|Report No. 56645/50/86.
Method: other: reported as freezing point
IRDC (1977) Acute Inhalation Toxicity (LC50) Study in Rats.|International Research and Development Corporation (IRDC).|Study #: 378-006. Study Date: June 23, 1977.
Method: other: Similar to guideline study
IITRI. 1988d. Abbreviated acute dermal|irritancy/corrosivity study of trimellitic acid in rabbits. |Study No. 1426. Test article No. 228C.
Schering AG. 1968. Systemische Vertraglichkeit nach einmaliger Verabreichung (DL50). ZK-Nr.: 21.979. 15.08.1968.
ELF ATOCHEM: ACIDE AMINO-11 UNDECANOIQUE.Détermination de |l'inhibition de la croissance des bactéries (Pseudomonas |putida).Unpublished report.February 1995.
Unna K. (1939). J. Pharrnac. exp. Ther. 65, 95.
Method: other: OECD Guideline 301F, Toxicity control
Tsuda H, Kato K (1976) Potassium dichromate-induced|chromsome aberrations and its control with sodium sulfite in|hamster embryonic cells in vitro. Gann 67: 469-470
Genetic toxicity in vivo, IUC4#46/Ch.5.6
Eastman Chemical Company. 2004. Material Safety Data Sheet for "Eastman" DE Acetate
Xie D.Y. et al. Biomed.Environ.Sci., 3(2), 146-155 (1990a)
Tyl, R.W., Masten, L.W., Marr, M.C., Myers, C.B., Slauter, R.W., Gardiner, T.H., Strother, D.E., McKee, R.H., and Tyler, T.R.
Developmental toxicity / teratogenicity.002
Weisburger EK, Russfield AB, Homburger F, Bogner E,|VanDongen CG, Chu KC, (1978): Testing of twenty-one|environmental aromatic aminies or derivatives for long-term|toxicity or carcinogenicity. J. Environm. Pathol. Toxicol.|2, 325-356
Method: other: 25 rats/group, see also freetext ME
Balk, F.and Meuwsen, I.J.B. (1989) Respiration inhibition|test with nitrifing bacteria, N-aminoethylpiperazine (AEP). |Akzo Nobel Corporate Research, Analytical Chemistry|Department, unpublished report CRL F89086. Sponsor:|Delamine B.V.
EU Method C.11 (Biodegradation: Activated Sludge Respiration Inhibition Test)
Kushi A, Yoshida D and Mizusaki S (1985). Mutagenicity of|gaseous nitrogen oxides and olefins on Salmonella TA 102 and|TA 104, Mutat. Res., Vol. 147, pp. 263-264 (conference|abstract).
BASF AG (1977). Department of Ecology, report on screening|test No. PF65, 31 Jan 1977, unpublished.
Method: other: acute screening toxicity test according to BASF SOP
Fornace Jr., A.J.: Cancer Res. 42, 145-149 (1982), No information
Genetic toxicity in vitro, IUC4#218/Ch.5.5
Ciba-Geigy Ltd., Report on the test for inherent|biodegradability in a combined Zahn-Wellens/Carbondioxide|Evolution test of Irganox L107 (= Irganox 1076), Project No.|91 8132 ; 10.12. 1991.
Shimizu, H., The results of microbial mutation test for|forty-three industrial chemicals, Jpn, J. Ind. Health 27,|400-419, 1985.
2,2'-dimethyl-4,4'-methylenebis(cyclohexylamine) (IUC4 DSN 72)
Noda A, Kon N (1998b). In-vitro chromosomal aberration test|of dicyclohexylamine in cultured Chinese Hamster cells.|Ministry of Health and welfare (MHW, Japan) Toxicity Testing|Reports of Environmental Chemicals Vol. 6, 101-104, 123-126,|643-646.
Method: other: Guidelines for Screening Mutagenicity Testing of Chemicals (Japan), see also freetext ME
Chinese Hamster Ovary Cells, CHO-K1-BH4 (subclone D1)
Clark B, Furlong JW, Ladner A, Slovak AJM (1984) Dermal|toxicity of dimethyl acetylene dicarboxylate, N-methyl|pyrrolidone, triethylene glycol dimethyl ether, dioxane and|tetralin in the rat, Int. Res. Comm. System Med. Sci. 12,|296-297
Method: other: comparable to OECD guide-line 402
Bayer AG 1976, Internal Study, Range finding test with|Leuciscus idus
Monsanto report AB-84-X133 as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Suzuki J, Takahashi N, Kobayashi Y, Miyamae R, Ohsawa M,|Suzuki S (1987) Dependence on Salmonella typhimurium enzymes|of mutagenicities of nitrobenzene and its derivatives in the|presence of rat-liver S9 and norharman. Mutation Research|178: 187-193
Method: other: preincubation method, in the presence of rat liver S9 and norharman, 3 replicate plates at each dose level
Albert, R.E. et al.: J. Natl. Cancer Inst. 68, 597-603|(1982), No information
LaLonde RT, Perakyla H, Cook GP, Dence CW (1990)|Contribution of the 5-hydroxyl group to the mutagenicity of|mucochloric acid. Environ Toxicol Chemistry 9: 687-691
Monsanto Co. (1986) CHO/HGPRT mammalian cell forward gene|mutation assay (report no. PH 314-MO-005-83). Pharmakon|Res.Int., Inc. (OTS0534361, 86-920000156)
Craft, T.R. and Skopek, T.R.: Environ. Mutagen. 8, 19|(1986); abstract no. 50, No information
BASF AG: Department Toxicology, unpublished data, (84/217),|19.08.1985
van Delft, J.L. et al. (1983): Doc. Ophthal. 56, 61-67.
Beilstein Database. Copyright 1988-2005 Beilstein Institut|zur Foerderung der Chemischen Wissenschaften licensed to|Beilstein GmbH and MDL Information Systems GmbH.
BIBRA working group, Toxicity profile, 4 p (1988)
BASF AG, department of ecology, unpublished data|(Project No. 99/0484/50/1), 17.01.2000
Lee WY and Nicol JAC (1978). Individual and combined|toxicity of some petroleum aromatics to the marine amphipod|Elasmopus pectenicrus. Marine Biol. 48, 215-222.
Repeated dose toxicity: inhalation, IUC4#48/Ch.5.4
Roempp (1999). Lexikon Chemie (10th ed.). Georg Thieme|Verlag Stuttgart.
Hoechst AG (1977d) Akute orale Toxizität von|p-Nitrochlorbenzol an weiblichen SPF-Wistar Ratten.|Unveroeffentl. Unters. Bericht: 77.0171, 8. März 1977
Method: other: 10 rats/dose, Ts dissolved in sesame oil, observation time: 14 days, pathological examination, statistical analysis
Eder, E. et al., Molecular mechanisms of DNA damage|initiated by alpha, beta-unsaturated carbonyl compounds as|criteria for genotoxicity and mutagenicity, Environmental|Health Perspectives, 88,|99-106 (1990)
Toxicity to terrestrial plants, IUC4#19/Ch.4.6.2
Biodegradation in water and sediment: simulation tests, IUC4#70/Ch.3.5
Woutersen, R.A. et al.: J. Appl. Toxicol. 9, 39-46 (1989), No information
Welsch, C.W. et al.: Cancer Res. 48, 2068-2073 (1988);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and K. Mortelmans
Degussa AG, Acute immobility test with Daphnia Magna exposed|to ammoniumperoxydisulfat, Study no. 88-0015-DGO, 1988.
Method: other: Standardized Artemia Reference Center-test procedure
Lunkin VN (1967) Ref Zh Otd Vyp Farmakol Khimioter|Sredstva Toksikol, No. 12.54.1096; cited in: American|Conference of Governmental Industrial Hygienists,|Inc.(ACGIH, 1986). Documentation of the Threshold Limit|Values(TLV) and Biological Exposures, Indices(BEI), fifth|edition, 1986: o-Toluidine, p. 586-588
Gardner, R.J. et al.: Fd. Chem. Toxic. 23, 87-92 (1985);|cited in: Schaper, M.: Am. Ind. Hyg. assoc. J. 54 (9),| 488-544 (1993), No information
Hooftman, R.N. and J.M. de Wolf. 2003. Dibutyldichlorostannane (CAS# 683-18-1): Semi-static acute toxicity test with the zebra fish Brachydanio rerio. TNO Report No. V2495/03. September 2003.
Arthur JW and Eaton JG (1971) J Fish Res Bd Can, 28: 184
Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537; Escherichia coli WP2 and WP2 uvrA
BASF AG, Department of Toxicology, unpublished data (88/712)|28/5/1989
Method: other: after DIN 38 412, test procedure with aquatic organism Group L, Part L15
Salmonella typhimurium (TA100, TA1535, TA98, TA1537, TA1538)
Ghosh J, Nandi B, and Fries N (1982). Use of some volatile|compounds in the preservation of wheat grains from fungal|deterioration in storage under Indian conditions.|Z. Pflanzenkr. Pflanzenschutz 89(7), 410-418.
Carpenter C.P. et al.: Toxicol. Appl. Pharmacol. 28,|313-319, (1974)
Monsanto Chemical Comp. data (1980), submitted to the US|EPA cited in BIBRA Toxicity Profile (1991)
CR3 Kaffeeveredelung M. Hermsen GmbH, pers. communication|(letter), (1994)
Yoshioka Y (1985), Testing for the Toxicity of Chemicals|with Tetrahymena pyriformis, The Science of Total|Envirionment, 43, 149-157
Method: other: Cell multiplication inhibition tst
BASF AG, 2003, Department of Product Safety, unpublished|calculation, SRC PCKOCWIN v1.66, 25 June 2003
Method: other: calculated via SRC PCKOCWIN v1.66
Hofmann and Gelbke (1977) Bericht uber die|gewerbetoxikologische grundprufung. BASF Study for|Substanz-Nr 77/807, dated 10.10.77.
Bayer AG, Report No. 7511 and 7512, Unpublished data.
Ciba (1983). Salmonella/Mammalian-Microsome Mutagenicity|Test. Test Material: TK 10027 (Metilox). Unpublished report|# 830491. August 3, 1983.
Method: other: According to Ames, direct plating
Method: T03-03:FIFRA Pesticide Assessment Guidelines, Subdivision F, Section 81-1, "Acute Oral Toxicity Study" TSCA Health effects Test Substances, " Acute exposure, Oral Toxicity"
Lyman, W.J., Reehl, W.J., Rosenblatt, D.H. (1983). Handbook|of chemical property estimation methods. McGraw-Hill, New|York. p. 5-10.
Method: other: calculated based on using water solubility
BASF AG (1979) Unpublished report 78/277
Method: other: DIN 38412 part 15 (Draft)
BASF AG: Department of Toxicology, unpublished study, Report on the study of the acute toxicity on the golden orfe, (88/161), January 25, 1989
Lyman, W. J. et al., Handbook of Chemical Property|Estimation Methods, NY, 4-9 (1982)
Verscheuren K (1983) Handbook of Environmental Data on organic chemicals, 2nd edition.
Chemicals Evaluation and Research Institute (CERI), (2004).|SRC-KOWWIN v1.66.
Hoechst AG (1988): Unveröffentl. Unters. (Ber.-Nr. 88.0427)
Biodegradation in water: screening tests, IUC4#88/Ch.3.5
BASF AG, Department of Toxicology, unpublished results,|Proj. No. 50I0544/90061, 04 Jan. 1994
Goodwin, P.A. (1998) Unpublished report of Dow USA
Lyman WJ et al. (1982) Handbook of Chemical Property Estimation Methods NY: McGraw-Hill p. 5-4, 5-10.
Salmonella typhimurium TA1535, TA1537, TA1538
Senichenkova, I.N.: Gig. Sanit. 9, 35-38 (1991), No information
Kiplinger, G.R. 1994. Skin Corrosivity/Irritation Study in Albino Rabbits. Final Report. WIL Research Laboratories, Inc. WIL Project No.: WIL-160031. Study conducted for Elf Atochem North America, Inc.
Ceccherini, I. et al.: Mutagenesis 3, 39-44 (1988);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Sanina YP. (1965) The toxicity of terephthalic acid Toksikol|Nov Prom Khum Vesh 7 91-101 [Chem Abstr 63, 7549 1965]
McGregor DB, Brown A, Cattanach P, Edwards I, McBride D,|Riach and Caspary WJ (1988). Responses of the L5178Y tk+/tk-|mouse lymphoma cell forward mutation assay: III. 72 coded|chemicals, Environ. Molec. Mutagen. 2, 85-154.
Method: other: according to Clive and Spector, Mutat. Res. 44, 269-278 (1975) and Clive et al., Mutat. Res. 59, 61-108 (1979)
Method: other: 25 mice/sex/group, see also freetext ME
Contreras KM and Harris C (1995). Embryotoxicity of|methanol, formaldehyde, and sodium formate in the rat|conceptus in vitro: exposure by direct intraamniotic|microinjection. Abstract. Annual SOT meeting 1995.
Dow Corning Corporation (2002) The Hydrolysis of|Trimethoxysilane (CAS# 2487-90-3). Final report submitted|to the Silicones Environmental, Health and Safety Council|(SEHSC), Reston, VA 20190. Dow Corning Corporation study|number 9677.
Goodwin, P.A., West, R.J., (1998). Evaluation of ready|biodegradability of five glycol ethers using the OECD Method|301F: Manometric Respirometry Test. Dow Chemical Company|Study No. 981111. September 3, 1998. Unpublished study.
Csato M, Chubb DR (1996): Skin sensitisation study with Ro|02-8825/000 (Isophytol) in the guinea pig. Study 957D96|(performed at Quintiles England Ltd, Ledbury, England, no.|A/K/42471). Performed on behalf of F. Hoffmann-La Roche Ltd,|Basle, unpublished.
RCC Ltd. (2005) 3-Mercaptopropanoic Acid Methyl Ester (MMP):|Acute toxicity to rainbow trout (Oncorhynchus mykiss) in a|96-hour flow-through test. RCC Study Number 858403. December|1, 2005.
Zhao Y-H, He Y-B, Wang L-S (1995) Predicting toxicities of|substituted aromatic hydrocarbons to fish by toxicities to|Daphnia magna or Photobacterium phosphoreum. Toxicol Environ|Chem 51: 191 -195
S. typhimurium TA1535, TA100, TA1537, TA98
Dooley, C.A. and P. Kenis. 1987. Response of Bioluminescent Bacteria to Alkyltin Compounds. In Proc. Intern. Organotin Symp. Oceans 87 Conf., Halifax, N.S., Canada. Sept. 28-Oct. 1. 4:1517-1524.
Argese, E., C. Bettiol, A.V. Ghirardini, M. Fasolo, G. Giurin, and P.R. Ghetti. 1998. Comparison of in vitro submitochondrial particle and Microtox assays for determining the toxicity of organotin compounds. Environmental Toxicology and Chemistry. 17(6):1005-1012.
Moreno, O.M.: Report to RIFM (1980); quoted in: Ford, R.A.|et al.: Fd. Chem. Toxic. 26, 273-416 (1988)
Meng Z, Zhang B (1999) Polymerase chain reaction-based|deletion screening of bisulfite (sulfur dioxide)-enhanced|gpt-mutants in CHO-AS52 cells. Mutat Res 425: 81-85
Method: other: polymerase chain reaction-based deletion screening of gpt-mutants
Dean B.J. et al (1985), Mutation Research, 153, 57-77.
Fischer R, Fischer G, Kren G (1966). Die kritische|Mischungstemperatur in der Analytik. Pharmazeutische|Zentralhalle fur Deutschland 105 (2), 73-87.
Sasaki S, 1978, The Scientific Aspects of the Chemical|Substances Control Law in Japan, In: Hutzinger O. (1978)|Aquatic Pollutants: Transformation and Biological Effects,|Pergamon Press, Oxford, 283-298
Method: other: comparable to OECD Guide-line 301 C
Hansen, S.A. and L.G. Mahone (1977) Chloride Ion Recovery,|Part One: Fundamental study of water soluble methyl|silicones Report no. 1977-I0030-4701
BASF AG, Analytical Laboratory, Bestimmung des|Verteilungskoeffizienten Pow von 3-Methylbuten-2-al-1 in|Octanol/Wasser bei Raumtemperatur (25°C), unpublished study,|J.No. 128429/04, 19 July 1988
International Technical Information Institute (1975/76).|Toxic and Hazardous Industrial Chemical Safety Manual,|Japan. cited in Henschler, D.: MAK-Begruendung 1984.
Bayer AG 2001d, Calculation of the Photodegradation of|BHT according to SRC-AOPWIN, v1.90 (2000)
Method: other (calculated): acc. to AOPWIN, v.1.90 (2000)
Genetic toxicity in vitro, IUC4#137/Ch.5.5
Niimi AJ, Lee HB, Kissoon GP (1989) Octanol/Water Partition|Coefficients and Bioconcentration Factors of|Chloronitrobenzenes in Rainbow Trout (Salmo gairdneri).|Environ Toxicol Chem 8: 817 - 823
preimplantation mouse embryo (two-cell stage)
Deutsche Forschungsgemeinschaft (DFG): MAK-und|BAT-Werte-Liste 2000, p. 39
Hoberg, J.R. 2002. Glycidoxy - Toxicity to the Freshwater|Green Alga, Pseudokirchneriella subcapitata. Springborn|Smithers Laboratories, Wareham, MA. Report No. 12023.6130.
Degussa AG, unpublished report, 1990, Algal growth inhibition, Scenedesmus subsp. Degussa Report No. 90-0040-DGO
Costa, M.: Environ. Health Perspect. 92, 45-52 (1991), No information
Method: other: two-dimensional gel electrophoresis, immunoblotting (DNA-protein crosslinks)
Genetic toxicity in vitro, IUC4#457/Ch.5.5
Fellows RJ, Harvey SD, Ligotke MW, Li SW, Cataldo DA and Van|Voris P (1991). Environmental Persistence and Toxicity of|Diethyl Malonate and Methyl Salicylate. Gov. Rep.|Announcements and Index 20, NTIS/DE 91012775, 1-14.
Method: other: Measurement of photosynthetic electron transport in isolated chloroplasts
Chinese hamster SPD8/V79 and Sp5/V79 cell lines
Dow Corning Corporation. (1993) Report Number|1993-I0000-38675.
Tanaka, T. et al. (1993): Toxicol. Lett. 66, 295 - 304
Koppers Company (1970) Internal memo dated 6/8/70.
Leung, H.W. (1994) Evaluation of the genotoxic potential|of alkyleneamines. Mutation Research 320:31-43.
Smith, S.B. et al., Teratog. Carcinog. Mutagen. 8, 175-189|(1998)
Hoechst AG (1991): Einstufungsbegründung nach TA-Luft der|Abt. UCV (14.03.1991)
Trial 1+2, with and without S9-mix: Salmonella typhimurium TA98, TA100, TA1535, TA1537, Escherichia coli WP2uvrA|Trial 3, with S9-mix, Confirmation test: Salmonella typhimurium TA100
CHL Lungenzellen des Chinesischen Hamsters
Federation Proceedings, Federation of American Societies for|Experimental Biology (bethsheda, MD) USA V 4, page 142,|1945. (Via RTECS database).
Ciba-Geigy Ltd. 1974. Acute Inhalation Toxicity Study of TK-11692 in the Rat. Project No.: Siss 3985. 23.7.1974.
Method: other: not reported (OECD 403 compliant)
O'Brien (1988) Free Radical Biol. Med. 4:169-183.
NTP (2002) Testing status for 3,4-dichloronitrobenzene|(http://ntp-server.niehs.nih.gov)
Hazleton Laboratories America, Inc.: Project No. 2088-107,|03.10.1980
Kligermann, A.D. et al.: Environ. Mutagen. 5, 400 (1983);|abstract Cb-6, No information
Genetic toxicity in vivo, IUC4#77/Ch.5.6
ITRI. International Tin Research Institute. Toxicological Data on Organotin Compounds. Publication No. 538.
BASF AG (1988). Department of Ecology, Biodegradation, Unpublished Report, 20 December 1988.
BASF (1981) Biochemical oxygen demand in 5 days (BOD5)|(mucochloric acid). BASF AG, Dpt. of Ecology, 04.05.1981|(unpublished data; Reprint 16.07.2002)
BOD5 Method: other: according to DIN 38409 Part 51 (now DIN EN 5815-1)
Bringmann G and Kuehn R (1978). Grenzwerte der Schadwirkung|wassergefaehrdender Stoffe gegen Blaualgen (Microcystis|aeruginosa) und Gruenalgen (Scenedesmus quadricauda) im|Zellvermehrungshemmtest. Vom Wasser 50, 45-60.
Van Goethem F, Lison D and Kirsch-Volders M (1997).|Comparative evaluation of the in vitro micronucleus test and|the alkaline single cell gel electrophoresis assay for the|detection of DNA damaging agents: genotoxic effects of|cobalt powder, tungsten carbide and cobalt-tungsten carbide.|Mutat Res 392, 31-43.
Hansch, C., Leo, A., Hoekman, D.: Exploring QSAR.|Hydrophobic, Electronic, and Steric Constants. American|Chemical Society, Washington, DC, pages 10, 194, 201 (1995)
Method: other (measured): both phases analysed
Wade MC, Stolz J, Ode RH (1996). A study of the|biodegradability of cyclohexylamine and dicyclohexylamine by|aerobic biological treatment.
Biodegradation in water: screening tests, IUC4#10/Ch.3.6
Method: other: Japanese Guideline by MITI of 1974; corresp. OECD 301 C Modified MITI Test I
Flaherty, (1989), cited in: ELF Atochem, Hedset Data|Sheet, 12.07.93
Biodegradation in water: screening tests, IUC4#7/Ch.3.6
Bringmann G. et al (1976), GWF-Wasser/Abwasser, 117(9),|410-13.
Browning E (1965) Toxicity and Metabolism of Industrial|Solvents, New York, American Elsevier, 377-381
Belanger, S.E. et al., Am. Water Works Assoc. 83, 79-87|(1991)
Short-term toxicity to aquatic invertebrates, IUC4#28/Ch.4.2
Placak OR and Ruchhoft CC (1947). Studies on sewage|purification. XVII.-The utilization of organic substrates by|activated sludge. Sewage Works Journal 19, 423-440.
Method: other: protocol in Galloway Environm. Mol. Mutagen. 10 [Suppl 10],1-175, 1987; solvent control, positive control, harvest time: without S9: 18.5 hours, with S9: 13.6 hours
F. Hoffmann-La Roche Ltd, Technical Substance Documentation.
Abraham M, Le J (1999) The Correlation and Prediction of the|Solubility of Compounds in Water Using an Amended Solvation|Energy Relationship. J Pharmaceutical Sci 88 (9): 868 - 880
S. typhimurium TA98, TA100, TA1535, TA1537,TA1538
Inayama Y., Promoting Action of Glycerol in the Pulmonary|Tumorigenesis Model using a Single Administration of 4|Nitroquinoline-1-oxide in Mice, Jpn J Cancer Res,|77:345-350, 1986 (113).
CIT (1993) Reverse mutation assay on bacterial Salmonella typhimurium with 2-ethylhexyl thioglycolate. CIT report no. 10277 MMO, 19th August 1993.
Hoechst AG (1989): Unveroeffentlichte Untersuchung (89.0573)
BASF AG, Department of Toxicology, Study of prenol on|primary irritation in the eyes of white rabbits, unpublished|report (78/453), 23 April 1979
Method: other: Federal Register 38, No. 187, § 1500.42
BASF AG (1989). Department of Ecology, report No.|1/1122/2/88-1122/88, 31 Jan 1989, unpublished.
Eder E. et al (1980), Biochemical Pharmacology, 29, 993-998.
Lyondell Chemical Company (2005) Toxicity of Allyl Alcohol|20906MB (Lyondell Lot Number CX30609214) to the Unicellular|Green Alga, Pseudokirchneriella subcapitata. ABC|Laboratories, Inc. Study No. 48910
Method: other (measured): OECD Guideline 107 (1981)
Vedula, U., Unpublished report of The Dow Chemical Company|(inhalation teratology test) (1995)
Bayer AG, Loeser E (1979c) Akute perkutane Toxizität. Short|report, October 31, 1979
Method: other: 10 rats/dose, single dermal appl., fixed with a gauze dressing for 24 hours, observation time: 14 days
Dow Corning Corporation. (2008) An Acute Oral Toxicity Study|In Rats With O, O', O" - (ethenylsilylidyne)trioxime|2-butanone. Report Number 2008-I0000-58852.
OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
Loeser E (1978b). Bayer AG data, Akute orale Toxizität,|Dinitrotoluol X neue Ware, Oktober/30/1978.
CIBA-GEIGY, Ltd. 1989. Point Mutation Test With Chinese Hamster Cells V79. Test No. 894101. 11.04.1989.
Method: other: strain: Wistar (m); Smyth et al.
Hoechst AG (1992): Internal Calculation of the Department of|Plant Protection Agency and Ecology (1992-01-07)
Method: other (calculated): Medchem Software CLOGP3, Release 3.42, Pomona College, Cleremont CA.
Hanstveit, R. 2003. Dibutyloxostannane (Dibutyltin oxide, CAS No. 818-08-6): Determination of the ready biodegradability in a Manometric Respiration Test. TNO Report No. V4016/01. September 2003.
BASF AG, Ökologie, unveröffentlichte Untersuchung,|04.12.1998
Method: other (calculated): extrapolated from 50 degree C value of MSDS
CIBA-GEIGY, Ltd. 1982. Report on Eye Irritation in the Rabbit after Single Application of TK 10422. Project No.: 811809. 23.04.1982.
Method: other: EPA, §163.81.4, Federal Register Vol. 43, No. 163, August 22, 1978
Kennedy Jr. GL, Culik R, Trochimowicz HJ (1982). Teratogenic evaluation of 1,4-dichlorobutene-2 in the rat following inhalation exposure. Toxicol. Appl. Pharmacol. 64, 125-130.
van Ginkel, C.G. (1989) Toxicity of N-aminoethylpiperazine|for pseudomonas putida. Akzo Nobel Corporate Research,|Analytical Chemistry Department, unpublished report CRL|F89105. Sponsor: Delamine B.V.
Brungs, W.A. et al.: J. Water Pollut. Control Fed. 50,|1582-1637 (1978)|cited in: IPCS Environ. Health Crit. 89, (1989), No information
Kirsch, P., Hildebrand, B. (1991). Report on the Acute|Dermal Irritation/Corrosivity to the Intact Dorsal Skin of|Protectol PP in White Rabbits. BASF Akteingesellschaft.|Study No. 18H0634/902206, February 21, 1991. Unpublished.
Ato-Chimie (1978) Acute toxicity tests on rats oral and|percutaneous administration, IFREB report no. 801264, 26|january 1978.
Kawasaki M (1980). Experiences with the test scheme under|the Chemical Control Law of Japan: an approach to|structure-activity correlations. Ecotoxicol. Environ. Safety|4, 444-454.
Solubility in organic solvents / fat solubility, IUC4#6/Ch.2.6.1
U.S. EPA (Environmental Protection Agency) (1980). Ambient|water quality criteria for isophorone, Report No.|440/5-80-056, U.S. Department of Commerce / National|Technical Information Service PB81 11767j.
BASF AG, Department of Toxicology, unpublished data, Project|No. 10F0066/885110, 25.10.1988
BASF AG, Department of ecology and environmental analytics,|unpublished data on determination of the inhibition of|oxygen consumption by activated sludge by Glyezin A in the|activated sludge respiration inhibition test, Project No.:|99/0200/08/1, July 1999
Method: other: OECD Guide-line 209, 1993
Price KS, Waggy GT, Conway RA. 1974. Brine shrimp bioassay|and seawater BOD of petrochemicals. J Water Pollution|Control Federation 46: 63-77.
Suzuki T; J Computer-Aided Molecular Design 5: 149-66 (1991)
Chinese Hamster Lung Fibroblast Cell Line (V79)
Genetic toxicity in vitro, IUC4#175/Ch.5.5
ECETOC, Eye irritation reference chemicals data bank (2nd|edition), Technical Report No. 48 (2), 220 (1998)
Method: other: OECD Guide-line 405, 1981
Bushy Run Research Center (1985) Various Silane |and Silicone Samples Primary Skin Irritancy Studies |(IATA Classification). Project report 48-110, |September 4, 1985.
Report No. CTL/P/2011, Ecological and Toxicological|Association of Dyes and Organic Pigments Manufacturers,|unpublished report
Church C. Unpublished analysis Zeneca Brixham Environmental|Laboratory
Lide DR (Ed.). 2001-2. Handbook of Chemistry and Physics, 82nd Edition. CRC Press, New York.
Lide, DR (2001). CRC Handbook of Chemistry and Physics. 81st edition, CRC Press LLC.
Bushy Run Research Center (BRRC) (1990). Developmental|Toxicity Evaluation of Union Carbide ®|Organofunctional Silane A-187 Administered by Gavage to|Fischer 344 Rats; Bushy Run Research Center (BRRC); BRRC|report number 53-58, December 19, 1990.
Bertelo, C. 2001. Determining the solubility and rate of hydrolysis of organotin compounds. Unpublished industry report. ATOFINA Chemicals, Inc. November 30, 2001.
Monsanto Co (1985a) A chronic oral gavage study in rats with|p-nitrochlorobenzene. Bio/dynamics Inc. BD-80-486,|Proj.-No.: 80-2487, June, 1985, EPA-OTS0557088 and|EPA-OTS0526382
Method: other: according OECD Guideline 453, see also freetext ME
Bayer AG 1986a, Internal Study, Test on vapour pressure,|AP-No 682099
CEFIC (2003): Categorization of Precipitated Synthetic|Amorphous Silica and Silicates of Sodium Aluminium and|Calcium for the ICCA/HPV Process. Unpublished Report of|CEFIC Sector Groups ASASP/SASSI, Brussels 2003
Schering AG, Experimentelle Toxikologie. 1999. Growth inhibition test of di-n-butyltin oxide (ZK 26385) on the green algae, Scenedesmus subspicatus. Research Report No. IC28. Berlin, Germany. 17 February 1999.
Method: other: OECD Guideline 201 (1); Directive 92/69/EEC (2); OECD ENV/JM/MONO (2000)6 - Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures (26 June 2000)
diisooctyl 2,2'-[(dioctylstannylene)bis(thio)]diacetate (IUC4 DSN 30)
Method: other: alkaline elution assay (DNA strand breaks)
Genetic toxicity in vitro, IUC4#177/Ch.5.5
Herron and Huie: J. Phys. Chem. Ref. Data 2:467-518 (1973).
Fassett, D.W. (1963) Unpublished data Eastman Kodak. |Summarized in Patty's Industrial Hygiene and Toicology |2nd Ed. Interscience Publishers, New York, New York.
Kronberg L, Asplund D, Mäki J, Sjöholm R (1996) Reaction of|mucochloric and mucobromic acids with adenosine and|cytidine: formation of chloro- and bromopropenal|derivatives. Chem Res Toxicol 9: 1257-1263
Method: other: calculated with HYDROWIN v1.67
Höss S (2002): Toxicity of Isophytol and Pseudoionone on the|nematode Caenorhabditis elegans in artificial sediment.|Ecossa Report, 21.05.2002, on behalf of F. Hoffmann-La Roche|Ltd.
Onfeldt, A.: Mutat. Res. 182, 135-154 (1987);|cited in: RIFM database, location no. 6713
Genetic toxicity in vitro, IUC4#88/Ch.5.5
Method: other: US Federal Register 38: 187, Part 1500, Section 41, 1973.
Henkel KGaA, Ultimate biodegradability in the Closed Bottle|Test, Final Report R 0100904, October 2001 (107).
Day, J.S., (2000). Evaluation of Dowanol PPh in the mouse|bone marrow micronucleus test. Dow Chemical Company Study|ID Number 991204 (File # HET K-005220-010). 7 April 2000.|Unpublished report.
HGPRT locus in V79 cells of the Chinese hamster
Salmonella typhimurium (TA 98, TA 100, TA 1535, TA 1537, and TA 1538)
Repeated dose toxicity: oral, IUC4#100/Ch.5.4
Microbiological Associates (1984b). L5178Y TK+/- mouse|lymphoma mutagenesis assay. Report No. T2408.701005.
Miller RR et al. (1981) Toxicol Appl Pharmacol, 61, 368-377.
Hawley's Condensed Chemical Dictionary, 11th Ed., 1987. N.I.|Sax and R.J. Lewis, eds., Van Nostrand Reinhold Co., New|York.
Tsuchimoto, T. and Matter, B. E.: Arch. Toxicol. 42, 239-248|(1979);
Bennett D., Ridge M.A. (1988), Allyl Chloride: determination of the n-octanol/water partition coefficient using a reverse-phase HPLC method. Shell Res. Ltd, SGBR 88.009, Jan.
Fluck, E.R. et al.: Chem.-Biol. Interact. 15, 219-231|(1976);|cited in: RIFM database, location no. 4024
Genetic toxicity in vitro, IUC4#75/Ch.5.5
Hoechst AG (1984): Unpublished study. BONS TRTR Prüfung der|akuten oralen Toxizität an der männlichen und weiblichen|Wistar-Ratte (in German) (Ber. 83.0665), 5 Jan 1984
BASF AG, Product Safety, 3-Methylbut-2-en-1-ol (Prenol) -|Prenatal developmental toxicity study in Wistar rats, oral|administration (gavage), unpublished report (00/274),|project no. 30R0274/00116, 27 March 2002
Hoechst AG (1986): Unpublished study. beta-Naphthol D.|Prüfung der akuten oralen Toxizität an der männlichen und|weiblichen Wistar-Ratte (in German). Report number 86.1059,|15 Sep 1986
IARC (1977). IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man 15: Some Fumigants, the Herbicides 2,4-D and 2,4,5-T, Chlorinated Dibenzodioxines and Miscellaneous Industrial Chemicals. Lyon. pp. 149-154.
Microbiol Associates Inc., San RHC (1997) Unscheduled DNA|synthesis assay in rat primary hepatocytes. Lab Study No|TE344.380027, July 14, 1997 (at the request of|Berufsgenossenschaft der Chemischen Industrie, Heidelberg)
Method: other: OECD Guide-line 482, see also freetext TC
Biodegradation in water: screening tests, IUC4#42/Ch.3.5
CERI. (2004) Measurement of boiling point of p-toluic acid. Unpublished data.
Ishidate et al. (1984). Primary mutagenicity screening of|food additives currently used in Japan. Fd.Chem.Toxic. 22,|p623-636.
MHW, Japan (1998). Ministry of Health and Welfare, Toxicity|Testing Reports of Environmental Chemicals, 6, 579-591. |(The reverse mutation and in vitro chromosomal aberration|tests were performed by the Hatano Research Institute, Food|and Druge Safety Center.)
Method: other: Guidance for Screening Mutagenicity Testing of Chemicals (Japan) and OECD Guidelines No. 471 and 472
M. Ikeda, T. Unai and C. Tomizawa (1986) Degradation of the|Herbicide Orbencarb in Soils., J. Pesticide Sci., 11, 85-96.
LaLonde RT, Xie S (1992) A study of inactivation reactions|of N-acetyldcysteine with mucochloric acid, a mutagenic|product of the chlorination of humic substances in water|Chem Res Toxicol 5: 618-624
Gulati, D.K. et al., Prog. Mutat. Res. 5, 413-426 (1985)
NTP Technical Bulletin 9, Bethesda, MD, 1-12 (1983)
None specified (none "called out") in the narrative portion|of report.
Bayer AG (1986) Internal study (1986-02-13)|- Acute toxicity test with Leuciscus idus
Matsuoka, A., Hayashi, M., Ishidate, M. (1979): Chromosomal|aberration tests on 29 chemical combined with S9 mix in|vitro. Mutation Research, 66, 277-290.
Method: other: according to Salem, H.: Dissertation, Univ. of Toronto Canada (1958)
Machado, M.W. (2002). Aminosilane - Acute Toxicity to|Daphnids (Daphnia magna) Under Static Conditions. |Springborn Smithers Laboratories, Wareham, MA. Report No.|12023.6133.
Sakano et al. (1985) Mutation Research 147:272-273.
U.S. Department of Health and Human Services. 1978. Occupational Health Guideline for Organic Tin Compounds (as Tin). Public Health Service. Centers for Disease Control. National Institute for Occupational Safety and Health (NIOSH). September 1978.
acrylic acid, monoester with propane-1,2-diol (IUC4 DSN 117)
Syracuse Research Corporation. 2000. SRC PhysProp Database. http://esc.syrres.com/interkow/webprop.exe?CAS=1461-25-2 (accessed August 2, 2000).
Timson J (1973) Action of sodium sulphite on the mitosis of|human lymphocytes. Chromosomes Today 4: 211-214
Nagao M, Yahagi T, Honda M, Seino Y, Matsushima, Sugimura T|(1977) Demonstration of mutagenicity of Aniline and|o-Toluidine by Norharman. Proc Jap Acad 53: Ser. B. 34-37
Method: other: as described by Nagao et al., 1977
Method: other: according to Preston et al., 1987,Mutat. Res. 189,157-165, see also freetext TC
Hoechst AG (1991): Unveröffentlichte Untersuchung|(91-0022-01)
Ong, J.M., Stewart, J., Wen, Y., Whong, W. 1987. |Application of SOS umu-test for the detection of genotoxic|volatile chemicals and air pollutants. Environ. Mutagen., 9:|171-176.
Lide, D.R. (ed. in chief) (1995) CRC Handbook of Chemistry|and Physics, 75th ed., CRC Press, Cleveland, OH.
Delistraty,D.A. et al., Proc. Annu. Meeting,|WorldMariculture Soc. 8, 647-672, (1977)
BASF AG, (1978) Report on the study of the primary irritation to the intact skin of rabbits, Dept. of Toxicology, unpublished study, (XXV/219), Jan. 20, 1978
D'Addario AP and Jagannath DR (1981) Structure and resonance|effects on the observed mutagenic response of|mononitro-halobenzenes. Environ Mutagen 3: 325 (Abstr.)
Guseva, V.A.: Gig. i Sanit. 10, 102-103 (1972), No information
Bringmann G., Kühn R. Gwf-Wasser/Abwasser 117(9), 1976. as|cited in: Verschueren K. Handbook of Environmental Data on|Organic Chemicals 2nd Ed. 1983. Van Nostrand Reinhold Co.|Inc. NY.NY p. 301 Reference No.329.
HSDB (2003) Hazardous substances databank, choline chloride.|Feb. 7, 2003
Stoewsand, G.S et al., Synthetic sources of calories in the|diets of rats and dogs, Proc. Int. Congr. Nutr., 7th, 4:|1082-1087, 1966 (86).
Ask E (1997). Formi LHS; Minimum Inhibitory Concentration|study. Telelab AS, Skien; final report for Hydro Nutrition,|Oslo, Norway.
Biesinger, K.E. and Christensen, G.M. (1972) Effects of|various metals on survival, growth, reproduction, and|metabolism of Daphnia magna. J. Fish. Res. Bd. Canada,|29(12), 1691-1700.
Wooldridge, C.R. and Wooldridge, D.P. (1969) Internal damage|in an aquatic beetle exposed to sublethal concentrations of|inorganic ions. Ann. Entomol. Soc. Am., 62(4), 921-933.
Long-term toxicity to aquatic invertebrates, IUC4#30/Ch.4.5.2
Khangarot, B.S. and Ray, P.K. (1989) Investigation of|correlation between physicochemical properties of metals and|their toxicity to the water flea Daphnia magna Straus.|Ecotoxicol. Env. Safety, 18(2), 109-120.
Du Pont, Haskell Laboratory, 1967 , Report No. H4988
Acute toxicity: inhalation, IUC4#30/Ch.5.1.2
Boublik, T. Fried, V. and Hala, E. 1984. The vapor pressure|of pure substances: selected values of the temperature|dependence of the vapor pressures of some pure substances in|the normal and low temperature regions. Vol. 17. Elsevier|Science Publishers, Amsterdam, Netherlands)
Jobling S, Reynolds T, White R, Parker MG, Sumpter JP (1995)|A variety of environmentally persistent chemicals, including|some phthalate plasticizers, are weakly estrogenic. Environ|Health Persp 103: 582-587
BASF AG, Department of Ecology, unpublished study, Determination of the acute effect of Isobutyl acrylate on the swimming ability of the water flea Daphnia magna STRAUS, 1/0667/2/88-8667/88, 1988
Method: other: Directive 79/831/EEC, annex V, C
Connor, T.H. et al.: Mutat. Res. 119, 145-149 (1983), No information
American Cyanamid Company|Eighteen months carcinogenicty study of Compound III in the|maouse|unpublished report|Pharmacopathics Research Laboratories 1974
HGPRT locus Chinese hamster V79 cell mutation system
Wells D. A., Thomas H. F., Digenis G. A. (1988) Mutagenicity|and cytotoxicty of N-methyl-2-pyrrolidone and|4-(methylamino)butanoic acid in the Salmonella/microsome|assay, J. Appl. Toxicol., 8, 135-139
Daston, G.P. et al. Fund Appl Toxicol. 26:203-210. (1995)
Method: other: Chick embryo retina cell (CERC) assay
BASF AG, Department of "Marketing und Disposition|Duengemittel", Information of Sep 26, 1991
Method: other: DIN 38412 part 9, Determination of the inhibitory effect on substances in water on green algal growth
Eldred DV, Weikel CL, Jurs PC, Kaiser KLE (1999) Prediction|of Fathead Minnow acute toxicity of organic compounds from|molecular structure. Chem Res Toxicol 12: 670 - 678
Seal Sands Chemicals Ltd (1997). Technical Data Sheet - DCDPS. Issue Date: 1st November 1997, Revision no. 1.
Hedenstedt, A. (1978). Mutagenicity screening of industrial|chemicals: seven aliphatic amines and one amide tested in|the Salmonella/microsomal assay. Mutat. Res. 53, 198-199.
Epstein, S.S. et al.: Toxicol. Appl. Pharmacol. 23, 288-325|(1972)
Jagannath DR (1978) Mutagenicity evaluation of|benzotrichloride in the Ames salmonella/microsome plate|test. Final report. LBI project No 20988. Genetics assay No|3566 dated December 1978 with cover letter dated 7/27/82.|Velsicol Chem Corp FYI Submission FYI-OTS-1180-0107,|Washington, DC: Office of Toxic Substances, U.S.|Environmental Protection Agency
Method: other: according to Ames, B.N. et al., Mutation Res. 31, 347-364 (1975)
WIL Research Laboratories, Inc. (2000). Single Dose Study in|Albino Rats. WIL-401001. 09/07/00
Gezelius, K. and Fries, N.: Hereditas 38, 112-114 (1952);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
ABC Laboratories, Inc., Chronic Toxicity of Tributyl Phosphate |(TBP) to Daphnia magna Under Flow-Through Test Conditions, Project No. 38556, September 18, 1991 (at the request of the Synthetic Organic Chemical Manufacturers Association).
The 2000-2001 Aldrich Handbook of Fine Chemicals and |Laboratory Equipment
Alishev NV and Osipov BS (1966) Toxicity of m- and|p-Nitrochlorobenzene. Farm Toksi (Moscow) 29(5): 619-621
BASF Corporation, Technical Data Sheet Isobutyl Acrylate,|July 2001
Weil, C. S., Scala, R. A., Study of Intra- and|Interlaboratory Variability in the Results of Rabbit Eye and|Skin Irritation Tests, Toxicol. Appl. Pharmacol., 19,|276-360, 1971 (101).
DOW Chemical U.S.A (1975) Internal Study D0005116: The|Pollutional Evaluation of Compounds (1975-02-26)
Biodegradation in water: screening tests, IUC4#92/Ch.3.5
Acute toxicity: inhalation, IUC4#42/Ch.5.1.2
JETOC (Jap Chem Ind Ecolog Toxicol Inform Center) (1996)|Mutagenicity Test Data of Existing Chemical Substances:|31-34, 70, 394-397, January 1996
Method: other: preincubation method according to Ames, Mutat. Res. 31, 347 (1975); Maron, Mutat. Res.113, 173 (1983); highest doses used: cytotoxic, positive controls, solvent control (see also freetext Method)
Medvedev VA and Davydov VD (1972). Transformation of coke|chemistry individual organic products in a chernozemic soil.|Pochvovedenie 11, 22-28.
Biodegradation in water: screening tests, IUC4#150/Ch.3.5
Carpenter CP and Smyth HF (1946) Chemical Burns to the|Rabbit Cornea, American Journal of Ophtalmology 29,|1363-1372
MITI (1992) Biodegradation and Bioaccumulation Data of|Existing Chemicals Based on the CSCL Japan. Edited by|Chemicals Inspection & Testing Institute Japan, published by|Japan Chemical Industry Ecology-Toxicology & Information|Center, October 1992
Hasegawa, R. et al. (1990): Jpn. J. Cancer Res. 81, |871 - 877
Method: other: Lung and Thyroid Carcinogenesis Modification Assay
Morrison DP, Johnson LD, Myers DK, Unrau P (1980) Gene|conversion as an assay system for carcinogenic agents.|Radiat Res 83: 484
Method: other: QSAR Estimation Method: PCKOCWIN v1.66
Adsorption / desorption, IUC4#70/Ch.3.3.1
Ciba (1989b). Internal report. Physical Chemistry. December|27, 1989.
Method: other (measured): Ciba internal method; Thermogravimetry
BASF AG, Product Safety, unpublished calculation (according|to TGD Draft May 2002), 25 Oct. 2002
Caujolle et al. (1991) Comptes Rendus 160, 1079-1100 1966
Bailey, H and Spanggord R (1983). The Relationship Between|the Toxicity and Structure of Nitroaromatic Chemicals.|Aquatic Toxicology and Hazard Assessment: Sixth|Symposium,ASTM STP 80/2, 98-107
Lide D.R. (Ed.), CRC Handbook of Chemistry and Physics,|80th Ed., CRC Press, 1999-2000, page 3-278.
Bayer AG (1978). Untersuchung zur Haut- und|Schleimhautverträglichkeit, Briefbericht. Unpublished study|report.
BASF AG (2007). Department of Product Safety, unpublished calculation, 21 Jun 2007
Method: other (calculated): SRC AOP v1.92
CIBA-GEIGY, Ltd. 1993. Report of the Acute Toxicity Test of Irgastab T 22 M (TK 11638) on Daphnia (Daphnia magna Straus 1820). Study No. CG 928293.
Seifert, J. (1989) Teratogenesis of polychlorocycloalkane|insecticides in chicken embryos resulting form their|interactions at the convulsant recognition sites of the GABA|(pro)receptor complex. Bull. Environ. Contam. Toxicol. 42:|707-715.
Best EPH, Miller JL, Larson SL (2001) Tolerance towards|explosives, and explosives removal from groundwater in|treatment wetland mesocosms. Water Sci Technol 44 (11 - 12):|515 - 521
Chemicals Evaluation and Research Institute (CERI), Japan|(2000), Report on partition coefficient of K-15B,|Unpublished data.
BASF AG (1980): Unpublished results. As cited in:|Berufsgenossenschaft der chemischen Industrie (1995):|Toxikologische Bewertung. Beta-Naphthol. Nr. 135, Heidelberg
Amberger, V. A. and Vilsmeier, K.: Untersuchungen zur|Auswaschung von Dicyandiamid und dessen Abbau in|Ueberstauten Boeden, Z. Wasser-Abwasser-Forsch, 21,|140-144(1988)
Ciba (1982a). Skin Irritation in the Rabbit After Single|Application of TK 10027. Unpublished report # 811498. March|17, 1982.
Method: other: EPA, CFR 43, No. 163, August 22, 1978
Method: other (calculation): PCGEMS (eq 4-10)
Wildlife International, Ltd. (2004) Trimethylsilanol: A|96-Hour Static-Renewal Acute Toxicity Test with the Rainbow|Trout (Oncorhynchus mykiss). April 29, 2004.
Gillette L.A., Miller D.L. and Redman H.E. Appraisal of a|chemical waste problem by fish toxicity tests. Sewage Ind.|Wastes 24(11):1397-1401, 1952.
Bayer AG (1978) Akute orale Toxizitaet. Short report dated|March 21, 1978
Method: other: acute toxicity of benzotrichloride in male Wistar rats treated with undiluted substance by gavage
Bacterial (Salmonella typhimurium and E. coli)
Blanck, H. et al., Ecotox. Environ. Saf. 8, 339-351 (1984)
Method: other: Microtiter-Plates, visual evaluation
Toxicity to aquatic algae and cyanobacteria, IUC4#70/Ch.4.3
Cairns J, Scheier A (1959). The relationship of bluegill|sunfish body size to tolerance for some common chemicals.|Proc. 13th Ind. Work. Conf., Purdue Univ., Engineering|Bull., 43, 242-253.
Mosanto Study No.SH-82-11 as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Method: other: product investigations method
Method: other (calculated): KOWWIN version 1.66
Hossack DJN, Richold M, Jones E and Bellamy RP (1978a). Ames|metabolic activation test to assess the potential mutagenic|effects of isophorone. Huntingdon Research Centre,|Huntingdon, England, Report UKM 52/78204.
Method: other: Huntingdon Research Centre Protocol MCB/101
Middaugh, D.P., Couch, J.A., Crane, A.M. (1977): Responses|of early life history stages of the striped bass, Morone|saxatilis to chlorination. Chesap. Sci., 18(1), 141-153.
Method: other: EEC Directive 79-831, part B
ATOFINA (2001) Methyl ethyl ketone peroxide in phthalate|plasticizer: Acute toxicity (inhibition of mobility) to|Daphnia magna Straus. Report 01/SAEk/0538/DC. Unpublished|study.
Fieserova-Bergerova V, Pierce JT, and Droz PO (1990). Dermal|absorption potential of industrial chemicals: criteria for|skin notation. Am J Ind Med 17, 617-635.
Smith RA, Cohen SM and Lawson TA (1990). Acrolein|Mutagenicity in the V79 Assay - Short Communication,|Carcinogenesis 11, 497-498
BASF (1988): Kaliumsulfit, Wachstumshemmtest in Anlehnung an|Bringmann-Kühn. DUU/OO - A 520. File No. 9/0894/88,|21.07.1988
Smith, I., (1988): H.R.I.P.T ISC No 37, project No. 0130.|Report: 01304, Procter and Gamble, Strombeek Bever, Belgium,|9 p.
BASF AG, Department of Product Safety, unpublished data, Project No.: 27G0348/033056, 24 Mar 2005
Method: other: ISO 14593 (identical to OECD 310)
Hallier, E., Langhof, T., Dannappel, d., Leutbecher, M.,|Schroder, K., Goergens, H.W., Muller, A., Bolt, H.M., 1993.|Polymorphism of glutathione conjugation of methyl bromide,|ethylene oxide and dichloromethane in human blood: influence|on the induction of sister chromatid exchanges (SCE) in|lymphocytes. Arch. Toxicol. 67:173-178.
CMA Oxo-Process Panel; 1300 Wilson Blvd., Arlington Virginia|22209.
Toxicity to reproduction, IUC4#30/Ch.5.8.1
BASF AG (2003b). Isobutylidene-Di-Urea. One-Generation Study|(Reproduction and Fertility Effects) by Oral route (Gavage)|in Rats. BASF Project No. 77RO113/009069, 09 July 2003.
Method: other: similar to OECD TGs 421 and 416 (1995, 2001), but no second generation studied.
Adams E.M. et al (1940), J. of Ind. Hygiene and Toxicology,|22, 79.
Jaylet, A. et al.: Mutat. Res. 130, 218 (1984); abstract|II.1B.6, No information
Genetic toxicity in vivo, IUC4#36/Ch.5.6
Takahashi, K. et al.: Mutat. Res. 156, 153-161 (1985), No information
Hoechst AG (1991): Unpublished report (91.0621)
BASF AG (1977). Department of Ecology, report from 10 Feb|1977 (test start), unpublished.
BASF AG, 2002, Product Safety, SRC BCFWIN v2.14, data|assessment, 16 July 2002
Salmonella typhimurium TA102 and TA2638 and Escherichia coli WP2/pKM101 and WP2 uvr/pKM101
Adelman, D., K.R. Hinga, and M.E.Q. Pilson. 1990. Biogeochemistry of butyltins in an enclosed marine ecosystem. Environ. Sci. Technol. 24:1027-1032.
Matsushima T., Hayashi M., Matsuoka A., Ishidate M., Miura|K.F., Shimizu H., Suzuki Y., Morimoto K., Ogura H., Mure K.,|Koshi K., Sofuni T. 1999, Validation study of the in vitro|micronucleus test in a chinese hamster lung cell line|(CHL/IU). Mutagenesis 14(6), 569-580.
van Ginkel, C.G. and Stroo, C.A. (1992) Removal of|N-aminoethylpiperazine in a SCAS test. Unpublished report|CRL F92111 of Akzo NV.
OECD Guideline 302 A (Inherent Biodegradability: Modified SCAS Test)
Method: other: Singh et al. (1988) with some modifications
Shcherbina EI, Tenenbaum AE, and Bashun TV (1973).|Selectivity and Solvency of Mixed Solvents. Chem. Techn.|Fuils and Oils 9, 197-200.
Chemicals Evaluation and Research Institute (CERI), Japan|(1999b). Unpublished report
Yuan X, Lu G, Zhao J (2002) QSAR Study on the Joint Toxicity|of 2,4-Dinitrotoluene with aromatic compounds to Vibrio|Fischeri. J Einviron Sci Health A37 (4): 573 - 578
Method: other: bioluminescence (Microtox)
Toxicity to microorganisms, IUC4#160/Ch.4.4
Method: other: according to JIS K 0102-1986-71 (Japanese Industrial Standard)
This data was already in the ECB IUCLID file but no further|reference information than "Rhone Poulenc 1979" was given.|The study is not available to the notifier.
Short-term toxicity to aquatic invertebrates, IUC4#16/Ch.4.2
BASF AG 1992. Report: Study on the inhalation toxicity of Butyldiglykol as a vapor in rats. 90 day test including an abut 4-week post-exposure observation period. Project No. 50I0030/87002, dated Feb 28, 1992.
Hazleton France (1988): Rapport No. 801301 to Rhone-Poulenc|S.A.
Dychdala G.R. chapter 7 in Block (1983) Disinfection and|preservation, 157-182 - Lea and Febiger Publishers
RCC, LTD (2007) Preliminary Technical Statement Regarding|Water Solubility and Partition Coeffcient of MEKP
McKee et al. (1963) Water quality criteria; The Resources|Agency of California, State Water Quality Control Board;|cited in: Verschueren (1983)
Lide D.R. (Ed.), CRC Handbook of Chemistry and Physics,|80th Ed., CRC Press, 1999-2000, page 6-73.
BASF AG, Mischphasenthermodynamik, unveröffentlichte|Untersuchung, Bericht BRU 94.322, 10.08.1994
Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E (1983)|Salmonella mutagenicity test results for 250 chemicals.|Environm Mutagenesis Suppl. 1: 3-142
Weeks MH, Musselman P, Yevich PP, Jacobson KH, Oberst FW|(1964).|Acute Vapor toxicity of phosphorus oxychloride, phosphorus|trichloride and methyl phosphonic dichloride. Am. Ind. Hyg.|Assoc. J. 25, 470-475.
Martin FL, Cole KJ, Harvey D, Weaver G, Williams JA, Millar|BC, Phillips DH, Crover PL (2000) Activation of genotoxins|to DNA-damaging species in exfoliated breast cells. Mutat|Res 470: 115-124
Genin VA, Pliss GB, Pylev LN, Shabad LM (1978). Gig Tr Prof|Zabol 7: 10-15; citied in: Toxikolog.-arbeitsmed.|Begruendung von MAK-Werten, VCH (1986)
Lutz D, Eder E, Neudecker T, Henschler D (1982)|Structure-Activity Relationships in Alfa, Beta-Unsaturated|Carbonylic Compounds and their Corresponding allylic|alcohols. Mutation Research 93, 305-315
Johannsen, F.R. et al.: Toxicol. Lett. 30, 1-6 (1986), No information
Repeated dose toxicity: oral, IUC4#61/Ch.5.4
Salmonella typhimurium strains: TA98, TA100, TA1535 and TA1537
Monsanto Chemical Co. (1987) unpublished study no.|WI-86-363. Cited from BUA Report 208, 1996
Primary skin irritation on rabbits is recorded in a 10-grade ordinal series and is based upon the severest reaction that develops on the clipped skin of each of five albino rabbits within 24 hours of the uncovered application of 0.01 ml of undiluted samp
IIT Research Institute. 1990. Abbreviated Acute Dermal|Irritancy/Corrosivity Study of Isophthalic Acid in Rabbits. |Study No. 1552.
Jones KA and Hara TJ (1988) Can J Fish Aquat Sci, 45,|749-753
Short-term toxicity to fish, IUC4#38/Ch.4.1
Neely, W.B. and Blaue, G.E. 1985. As cited in SRC PhysProp|Database. 2001.|http://esc.syrres.com/interkow/webprop.exe?CAS=528-44-9.
Method: other: (semi)chronic toxicity test
Reeber F, Vogel A. (1992) FAT 65'023/N: Fat solubility.|CIBA-GEIGY Ltd., CH-4002 Basel (Switzerland), Report No.|FC-90/30T.FS
Solubility in organic solvents / fat solubility, IUC4#11/Ch.2.6.1
Gollapudi B, Linscombe VA, McClintock ML, Sinha AK and Stack CR. 1993. Toxicology of diethylene glycol butyl ether 3. Genotoxicity evaluation in an in vitro gene mutation assay and an in vivo cytogenetic test. J Am Coll Toxicol 12: 155-159
Kempa,E.S., Oesterreichische Abwasser-Rundschau 2, 20-25,|1976, No information
Mukai FH, Hawryluk I (1973). The mutagenicity of some halo-ethers and halo-ketones. Mutat. Res. 21 (33), 228.
Deneer, J.W. et al., Quantitative structure-activity|relationships for the toxicity and bioconcentration factor|of nitrobenzene derivatives towards the guppy (Poecilia|reticulata), Aquatic Toxicology, 10, 115-129 (1987)
Method: other: comparable to OECD 305B (Bioaccumulation: Semi Static Fish Test) (1981)
Henkel KGaA, Glycerin PH.EUR. 99.5% Zellvermehrungshemmtest|mit Bakterien (Report no. 9400063), 1994 (108)
DIN 38412, part 8 (Pseudomonas Zellvermehrungshemm-Test)
Kawai A, Goto S, Matsumoto Y, Matsushita H (1987)|Mutagenicity of aliphatic and aromatic nitrocompounds. Jpn J|Ind Health 29: 34-54
McGregor DB Brown A, Cattanach P, Edwards I, McBride D, Caspary WJ (1988) Responses of the L5178Y TK+/TK- mouse lymphoma cell forward mutation assay. II: 18 coded chemicals. Environmental and Molecular Mutagenesis 11:91-118.
Method: other: McGregor et al (1988) and Clive et al (1979)
Horstman, M.G. et al.: The Toxicologist 11, 87 (1991) |(abstr.)
Bayer AG (2003). Internal Study: Alga, Growth Inhibition|Test. Study No. 1290 A/03 Al.
DeYoung, D.J. et al.: Bull. Environ. Contam. Toxicol. 56,|143-150, (1996)
Method: other: according to Birge, W.J. et al.: Environ. Toxicol. Chem. 4, 807-821
Hatch GG, Anderson TM, Lubet RA, Kouri RE et al. (1986)|Chemical enhancement of SA7 virus Transformation of Hamster|embryo cells: Evaluation by interlaboratory testing of|diverse chemicals. Environmental Mutagenesis, 8, 515-531.
Wester, P.W., J.H. Canton, A.A.J. Van Iersel, E.I. Krajnc, and H.A.M.G. Vaessen. 1990. The toxicity of bis(tri-n-butyltin)oxide (TBTO) and di-n-butyltindichloride (DBTC) in the small fish species Oryzias latipes (medaka) and Poecilia reticulata (guppy). Aquatic Toxicology. 16:53-72.
Jaffe, R.L. (1995): Rapid assay of cytotoxicity using|tetramitus flagellates. Toxicol. Ind. Health 11(5), 543-558
Method: other: inhibition of cell division
Harder A (2002). Assessment of the risk potential reactive chemicals with multiple modes of toxic action. Diss. ETH No. 14966. Swiss Federal Institute of Technology Zuerich, Switzerland.
JETOC (1996) Mutagenicity test data of existing chemical|substances: 41-46, 56, 472-473
Method: other: according OECD Guide-line 473, see test conc., cytotoxicity was determined prior to testing, treatment time +S9: 6 hrs, 18 hrs further incubation after change of medium, positive control: MMC, BaP
Weinstein, D. et al.: Mutat. Res. 16, 391-399 (1972);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
BASF AG, Department of Toxicology, unpublished results,|Proj. No. 36I05876/89023, 19 May 1995
Bringmann G. & Kuehn R., Ergebnisse der Schadwirkung|wassergefaehrdender Stoffe gegen Daphnia magna in einem|weiterentwickelten standardisierten Testverfahren, Z. Wasser|Abwasser Forsch. 15 (1): 1-6, 1982 (73)
Inversk Resarch International(IRI).(1991b), Dermal|irritation test in rabbits-28day repeated application.|Report No.6916, Unpublished report
BASF AG (1963) Toxicity of choline chloride 70% in water.|Department of Toxicology, unpublished results, Study No.|XIII 9, Re.Nr. 1625, 01.03.1963
Ministry of Health and Welfare: Japan, Toxicity Testing|Reports of Environmental Chemicals 5, 475-498 (1997)
Shivapurkar N, Hoover KL, Poirier LA (1986) Effect of|methionine and choline on liver tumor promotion by|phenobarbital and DDT in diethylnitrosamine-initiated rats.|Carcinogenesis 7: 547-550
BASF AG, Department of Experimental Toxicology and Ecology. |N-(2-aminoethyl)ethanolamine - Mechanistic Toxicity|Screening Test in Wistar rats. Oral application (gavage).|Unpublished report No. 06R0019/01136, 21 Feb 2005.|Sponsored by the Ethyleneamines Product Stewardship|Discussion Group (EPSDG) and CEFIC Ethyleneamines Group.
Method: other: mechanistic study; not accodring to test guidelines
Method: other: in accordance with Ames et al., Mutat. Res. 31, 347-364 (1975)
Chanet, R. and von Borstel, R.C.: Mutat. Res. 62, 239-253|(1979), No information
Dupont de Nemours (1978) Mutagenic activity in the|salmonella/microsome assay. Haskell Lab. Rep.-No. 392-78:|EPA-OTS0557122
Method: other: according to Ames et al., Mutat. Res. 31: 347 (1975), negative and positive controls (2AA, MNNG, 2NF, 9-AA)
Salmonella typhimurium: TA97, TA98, TA100, TA1535 and TA102.
de Groot, W.A. (1998) The toxicity of sodium chloride and|calcium chloride to algae (Selenastrum capricornutum).|Solvay Pharmaceuticals Study No. C.SOL.51.113/Int.Doc. No.|56834/56/98.
Fujikawa K, Haruko R, Kondo S (1985) The Drosophila|reversion assay using the unstable zeste-white somatic eye|color system. Prog Mut Res 5: 319-324
Method: other: Rasmuson et al. (1978): Mut. Res. 54, 33-38
Smyth, H.F., Carpenter, C.P., Weil, C.S. and U.C. Pozzani (1969)|Range-Finding Toxicity Data: List VII. Am Ind Hyg Assoc J|30: 470 (1969). Cited in AIHAJ (1997) Workplace Environmental|Exposure Level Guides: Trimethoxysilane (1997).
BASF AG (1996). Department of Toxicology. Report on the|study of 4-Ethylmorpholin in the Ames Test. Unpublished|study No. 40M0172/954111, dated 29 March 1996.
Clemens, H.P. and Sneed, K.E.: "Lethal doses of several|commercial chemicals for fingerling channel catfish";|Washington DC, U.S. Department of the Interior (Spec. Scl.|Rep. Fish No. 316), (2959);|cited in: IPCS Environ. Health Crit. 89, (1989), No information
Short-term toxicity to fish, IUC4#66/Ch.4.1
Migchielsen, M.H.J. 2004. 8-Oxa-3,5-dithia-4-stannatetradecanoic acid,10-ethyl-4-[[2-(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-methyl-7-oxo-,2- ethylhexyl ester [Methyltin tris(2-ethylhexylmercaptoacetate), CAS No. 57583-34-3]: 96-Hour acute toxicity in zebra-fish with MMT(EHMA) (semi-static). NOTOX Project 374952. TNO study number 5307/01. September 3, 2004.
Wells Laboratories, Inc. 1975. Report on Inhalation LC50 in Rats. Laboratory No. G-465. 2.10.1975.
Method: other: Hazardous Substances Labelling Act, Part 191, Chapter 1, Title 21, CFR, paragraph 191.1.
Howard, C.A. et al., Prog. Mutat. Res. 5, 457-467 (1985)
Nishino SF, Spain JC (2000) In situ biodegradation of 2,4-|and 2,6-dinitrotoluene. In: American Society for|Microbiology. Abstracts of the General Meeting of the|American Society for Microbiology, Los Angeles, California,|USA May 21-25, 2000, Volume 100, pp. 594-595.
Method: other: Shake flask and soil column studies
BASF AG, Department of Toxicology, Report on the acute|dermal irritation / corrosivity to the intact dorsal skin of|beta-Ionone in white rabbits, unpublished report, project|no. 18H0245/912113, 13 May 1992
Salmonella typhimurium TA 98, TA 100; Escherichia Coli WP2, WP2uvrA(P)
Naumova, Usmanova, Lisin, Shchurov (1984): Biol. Nauki|(Moscow) 2, 96-100; cited in: Chem. Abstr. 100, 161361s|(1984)
Industrial Biology Laboratories Inc, Shelanski MV (1964 a)|Study report Project No. SH-64-5. Unpublished study of|Monsanto Chemical Co. Dermal sensitization of Santoflex|compounds in humans. NTIS/OTS 570859, EPA/OTS document #|88-920008571 (1992)
NTP, Technical Report Series No. 214 (1982)
Ciba-Geigy Ltd., Report on the test for acute toxicity of TK|10044 to rainbow trout, Project No. 840056; 12.4.1984.
Ward GS, Parrish PR and Rigby RA (1981). Early life stage|toxicity tests with a saltwater fish: effects of eight|chemicals on survival, growth, and development of sheepshead|minnows (Cyprinodon variegatus). J. Toxicol. Environ. Health|8, 225-240.
Method: other: Early Life Stage Test based on a Procedure of the Committee on Methods for Toxicity Tests with Aquatic Organisms
Long-term toxicity to fish, IUC4#30/Ch.4.5.1
Goldberg, M.E. and Johnson, H.E., Autonomic Ganglion|Activity and Acute Toxicologic Effects of|N,N,N',N'-Tetramethyl-1,3-butanediamine and|Triethylenediamine, Two Foam Catalyst Amines, Tox. and|Applied Pharm. 4, 522-545, 1962
Elmorsi, Hopper. (1981): Biochem. Soc. Trans. 9, 431
Biodegradation in water: screening tests, IUC4#44/Ch.3.5
BiblioLine (R) (2004) Database File: (RTECS [TOXICITY,|CARCINOGENICITY, TUMORIGENICITY, MUTAGENICITY,|TERATOGENICITY]) OR HSDB SUBSET [HAZARDOUS SUBSTANCES DATA|BANK]
FMC Corporation, Ammonium persulfate: primary skin|irritation study in rabbits, Study no. I87-0970, 1988.
Crebelli R, Falcone E, Aquilina G, Carere A (1984) Mutagenicity studies in a tyre plant: in vitro activity of workers' urinary concentrates and rubber chemicals. IARC Scientific Publications 59:289-295.
Amoco Chemicals Co. (1992) Data cited in a letter with|enclosures from Amoco Chemicals Co. to ICI Chemicals &|Polymers Limited. Dated January 29, 1993
Watkins CH and Hammerschlag RS (1984) Water Res, 18, 1037-43
Toxicity to aquatic algae and cyanobacteria, IUC4#18/Ch.4.3
Jung, R. et al. (1992) Mutation Research, 278, 265-270.
Pestic. Index 5th Ed. 1976. Vol. 5, 32 (1976); zitiert in: RTECS (1991)
Method: other: calculated with BCFWIN v2.15, 2000
Wilson GM, VonNiederhausern DM, and Giles NF (2002).|Critical Point and Vapor Pressure Measurements for Nine|Compounds by a Low Residence Time Flow Method. J. Chem.|Eng. Data 47, 761-764.
Ullmann's Encyclopedia of Industrial Chemistry (1985): Vol.|A2, 19, 25
Hong H, Wang L, Han S, Zou G (1996) Prediction Adsorption|Coefficients (Koc) for Aromatic Compounds by HPLC Retention|Factors (K'). Chemosphere 32 (2): 343 - 351
Lewis RJ (Ed.). 1993. Hawley's Condensed Chemical Dictionary, Twelfth Edition, Van Nostrand Reinhold Company, New York.
Ashford, R.D. Ashford's Dictionary of Industrial Chemicals.|London, England: Wavelength Publications Ltd., 1994., p.|595. cited in HSDB 21 Sep 2006
Bringmann G and Kuehn R (1977). Grenzwerte der Schadwirkung|wassergefaehrdender Stoffe gegen Bakterien (Pseudomonas|putida) und Gruenalgen (Scenedesmus quadricauda) im|Zellvermehrungshemmtest. Z. Wasser- Abwasser Forsch. 10|(3/4), 87-98.
JETOC (Japan Chemical Industry Ecology-Toxicology and|Information Center, Japan): mutagenicity test data of|existing chemical substances based on the toxicity|investigation system of the industrial safety and health|law, Supplement, Feb. 1997
Method: other: OECD Guide-line 471, preincubation method, S9-mix from rat and from hamster, highest dose cytotoxic, solvent and positive controls
National Toxicology Program (NTP), 84-023 Annual Plan for|Fiscal Year, February, 1984
Reported in Du Pont - Haskell Laboratory - Internal DMAC|Review, Oct. 1988 from Monsanto Chemical Company,|Unpublished Data: Report No. BDN-75-61, Project No. 75-1267,|January 7, 1980.
Kieckebusch, W. & Lang, K., Arzneim.-Forsch. 10: 1001-1003|(1960)
BASF Aktiengesellschaft. 2000. Determination of the Biodegradability of TZ 03502 in the Manometric Respirometry Test. Project No. 99/0610/26/2. Ludwigshafen, Germany. 17.11.00.
EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
Hanst P, Spence J and Edney E (1980). Carbon monoxide|production in photooxidation of organic molecules in the|air, Atmospheric Environ., Vol. 14, No. 9, pp. 1077-1088.
Biodegradation in water: screening tests, IUC4#38/Ch.3.5
Hüls AG (1990). Bestimmung der Mutagenität von|Isophorondiamin im|Salmonella/Säuger-Mikrosomen-Mutagenitätstest nach Ames.|Report No. AM-90/6 (unpublished).
Internal correspondence from Dr. H. Miklautz to Dr. Uzick. 17.07.1987. RE: Ihr Schreiben vom 12.03.87 bezüglich der Dampfdruckmessung der nachstehenden Alkylzinnchloride. MBTCl, DBTCl, MOTCl, DOTCl, MDTCl, DDTCl.
Meylan, W.M., et al. 1996. IN Syracuse Research Corporation. SRC PhysProp Database. http://esc.syrres.com/interkow/webprop.exe?CAS=1461-25-2 (accessed August 2, 2000).
Al-Abbas, A.H. et al.: Acta Universitatis Palackianae|Olomucensis-Tom 113, 35-52 (1986), No information
Von der Hude, W. et al.: Mutation Research 203, 81-|94 (1988)
Loewengart, G., Proc. Symp. Ind. Approach Chem. Risk|Assess.; Caprolactam, 36-52 (1984)
Kleniewska D. (1975): Studies on hypersensitivity to "para|group". Citation, no data concerning the journal, volume,|pages
Method: other: no details of application mode given, pathologic (gross and histologic) evaluation, post appl. observation period: 14 d
Infracor Degussa Group (1996) Final Report FK 1253|(non-GLP): DYNASYLAN GLYMO Determination of the acute|toxicity for the fish Cyprinus carpio (Acute fish toxicity|test) (English translation of the German Final Report dated|25.10.1996). Degussa AG-Nr.: 96-0179-DKO.
Morton, C.A. et al. (1995), Contact sensitivity to menthol|and peppermint in patients with intra-oral symptoms,Contact|Dermatitis 32, 281-284
Method: other: Andersen, K.G., Contact Dermatitis 4, 195-198 (1978)
Groeneveld, A.H.C and Kuijpers, L.A.M., (1991). The Toxicity|of HCFC 141b to the Alga Selenastrum Capricornutum. Report|No. 56635/49/90 Duphar B.V. Group Ecotoxicology CPD 1243|JJ's-Graveland, The Netherlands.
Method: other: OECD Guideline 201 (1984); EPA guideline 40 CFR Part 797 & 1060 (1989)
van Went GF (1985) The test foe sister-chromatid exchanges|in Chinese hamster V79 cells in culture. Prog Mut Res 5:|469-477
Genetic toxicity in vitro, IUC4#124/Ch.5.5
Warne SST and Schifko AD (1999). Toxicity of laundry|detergent components to a freshwater Cladoceran and their|contribution to detergent toxicity. Ecotox Environ Safety|44, 196 - 206.
Method: other: Australian NSW Environment Protection Authority
Dambleff J (1908) Beitraege zur Kenntnis der giftigen|Wirkung nitrierter Benzole und Toluole insbesondere von der|Haut aus. Dissertation, Wuerzburg 6. Juli 1908
Method: other: powdered TS was applied on the unshaved skin (200 cm2). TS was covered from cloth, then fixed with an abdominal binder, followed by staniol foile, and finally bandaged, not removed until the end of the observation time: 50 hrs
Atlas Chem. Ind. 1969, unpublished data.
Test on 1-octanol/water partition coefficient of Flon 124,|Krume Research Laboratories, Japan, Test No. 80646, December|1991
Method: other: Estimated value with BCFWIN v.2.15
von Oettingen, W.F., Powell, C.C., Sharpless, N.E., Alford,|W.C. and Pecora, L. JK.: Nat. Inst. Health Bull. 191|(1949).
Nesnow S, Curtis G, Garland H (1984) Evaluation of WHO-IPCS|chemicals by the C3H10T1/2CL8 morphological transformation|bioassay. Health Effects Research Lab. USEPA, PB84-167501
Method: other: other: according Reznikoff, C.A. et al. (1973): Cancer Res. 33, 3231-3238
Allied Biochemical Toxicology Dept. (1979) Short-Term Mutagenicity and Cell Transformation Screening of Toluene Diamine, V. Chemical Transformation of Secondary Hamster Embryo Cells, EPA Document No. 40-8336132, Fiche No. OTS0506071. (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com)
Berufsgenossenschaft der chemischen Industrie, Contact|Hypersensitivity to Triethylenediamine in Albino guinea Pigs|- Maximization Test, APCI RRRS EXT-03/032, 6 June 1988
Repeated dose toxicity: inhalation, IUC4#88/Ch.5.4
Haworth, S. et al.: Environ. Mutagen. Suppl. 1, 3-142 (1983), No information
Method: other: respiration inhibition test
Method: other: males(1-3d old), mated with 3x with Basc virgin females brood1: 3d, brood2: 2d, brood3: 2d;
Johannsen F.R. et al. (1987). Fundam. App. Toxicol.|9:550-556.
Schering AG. 1973. Systemische Vertraglichkeitsprufung (DL50) nach einmaliger i.g. Verabreichung von Ak 44.682 an Ratten. Prot. Nr. 3532. 19.4.1973.
Solubility in organic solvents / fat solubility, IUC4#75/Ch.2.6.1
V79 Chinese Hamster cells derived from embryonic lung tissue
Reported by Kennedy G.L. (1986), CRC Crit. Rev. Toxicol.,|17:129-182 from Du Pont, Haskell Laboratory, Unpublished|Data: short-term toxicity..
Grade R., 1994, Report on the growth inhibition test of linalylacetat to green algae (Scenedesmus subspicatus), Ciba-Geigy Ltd.
Fassett & Irish (ed.), Patty's Industrial Hygiene|and Toxicology, sec. ed. (1963)
Schmid, E. et al.: Mutagenesis 1, 427-431 (1986), No information
Genetic toxicity in vitro, IUC4#162/Ch.5.5
Allen, J.R. & Engblom, J.F. (1972): Food Cosmet. Toxicol.|20, 769-779
Bridie AL, Wolff CJM, Winter M. 1979. BOD and COD of some|petrochemicals. Water Research 13: 627-630.
BOD5 Method: other: Standard dilution method (APHA Test Standard Method #219), 1971
Li K.C., Powell D.C., Aulerich R.J., Walker R.D., Render|J.A., Maes R.K., and Bursian S.J. (1999). Effects of|formalin on bacterial growth in mink feed, feed consumption|and reproductive performance of adult mink and growth of|mink kits. Vet.Human Toxicol. 41, 225-232., No information
CIBA-GEIGY, Ltd. GU2 Toxicology. Acute Oral LD50 In The Rat. GU Project No. 820514. 22.6.1982.
BASF AG (2005). Natriumformiat-Lösung. Material safety data|sheet according to 91/155/EEC, last update 04 Aug 2005.
Salmonella typhimurium TA100, TA1535, TA97, TA98
Shimazu, H., Shiraishi N., Akematsu T., Ueda N., Sugiyama T. Carcinogenicity screening tests on induction of chromosomal aberrations in rat bone marrow cell in vivo. Mutation Research. 38, 347a (1976)
Ishihara, M., Nogami, T., Itoh, M. and Nishimura, M. (1985) Sensitization Potency of Dye Intermediates and Modifiers in Guinea Pigs. Hifu Skin Research, Vol 27 pages 585 - 589.
International Tin Research Institute (ITRI). Toxicological Data on Organotin Compounds. Publication No. 538.
Short-term toxicity to aquatic invertebrates.001
Bosworth, D. et al.: Mutagenesis 2, 455-467 (1987), No information
Method: other: Bacterial forward mutation assay tes (bacteria)
Moss,J.L., Prog. Fish-Cult. 40(4), 158-160, 1978, No information
Boelhouwers EJ (2007). Hydrolysis of 4,4'-Dichlorodiphenyl sulfone (DCDPS) as a function of pH. Solvay Pharmaceuticals Int. Doc. No. 7811/0055/2006.
Clariant GmbH (1998): EC safety data sheet Genamin LA 302 D|(08.10.98)
Method: other: NEN 6501: Determination of acute toxicity with Daphnia magna (1980) with slight modifications (Van Leeuwen et al. 1985)
adipic acid, compound with hexane-1,6-diamine (1:1) (IUC4 DSN 30)
Tsuchiya, K. et al.: Keio J. Med. 24, 19-37 (1975);|cited in: IPCS Environ. Health Crit. 89, (1989), No information
Daubert, T.E.; Danner, R.P.; Physical and Thermodynamic Properties of Pure chemicals data compilation design institute for physical property data, American institute of chemical engineers hemisphere pub. New York, NY., 4, 1989
Pharmakon Research Int., Inc., CHO/HGPRT Mammalian Cell|Forward Gene Mutation Assay, PH 314-UN-001-84, Flexzone 7F.|Unpublished study of Uniroyal Chemical Co., September 25,|1984
Hermens J. et al (1985), Tox. Env. Chem., 9, 219-36.
BASF AG, Analytisches Labor; unveroeffentlichte|Untersuchung (BRU 88.221)
Munch J.C. Aliphatic Alcohols and Alkyl Esters: Narcotic and|Lethal Potencies to Tadpoles and to Rabbits. Ind. Med. Surg.|41(4):31-33. 1972.
BASF AG, Toxicology Research Department, study report|40M0968/884404, 21.03.1989
BASF AG, Analytical department, unpublished report, J.Nr.|128429/02, 19.07.1988
S. typhimurium TA98, TA100, TA1535, TA1537
Miyata R, Nohomi T, Yoshikawa K, Ishidate M Jr (1981)|Metabolic activation of p-nitrotoluene and trichloroethylene|by rat-liver S9 or mouse-liver S9 fractions in Salmonella|thyphimurium strains. Eisli Shikensko Hokoku 99: 60-65
Method: other: preincubation method, highest concentration: toxic, positive, negative and solvent control
Mehta RD, von Borstel RC (1985) Tests for genetic activity|in the yeast Saccaromyces cerevisiae using strains|D7-144,XV185-14C and RM52. Prog Mut Res 5: 271-284
Method: other: as described by Mehta and von Borstel (1982)
Perez C, Soderholm S (1991). Some chemicals requiring|special consideration when deciding whether to sample the|particle, vapor, or both phases of an atmosphere. Applied|Occupational and Environmental Hygiene 6(10), 859-64
Christopher, S.M. November 30, 1993. "Isobutanol: Acute toxicity and irritancy testing using the rat (peroral and inhalationtoxicity) and the rabbit (cutaneous and ocular tests)".Bushy Run Research Center, Union Carbide Corp.Lab. Proj. ID92U1166
Pilát P and Prokop A (1975). The effect of methanol,|formaldehyde, and formic acid on growth of Candida boidinii|11 Bh. Biotechnology and Bioengineering 17, 1717-1728.
Method: other: mitotic crossing over assay according Zimmerman, 1975
Method: other: Generoso et al., Mutat. Res. 73, 133-142 (1980)
Genetic toxicity in vivo, IUC4#80/Ch.5.6
Ayaz, M. et al., J. Food Protection 43, 4-6 (1980)
Pashley, E.L. et al. (1985): J. Endontics 11, 525-528.
Schering AG. 1990. ZK 22.663. Local Dermal Tolerance Test in Rats after a Single Application. Report No.: IC 15/90. 27.08.1990.
Bayer AG 1994, Internal Study, Test on acute toxicity to|fish, test report 466 A/94
Method: other: Directive 84/449/EEC, C.1 "Acute toxicity to fish" (1992)
Bayer AG (1992). Internal study: Acute Fish Toxicity of|Dicyclohexylamine, GLP-No. 404 A/92 F.
Method: other: EEC 67/548, C.1 (Draft 1992), comparable to OECD TG 203
Nielsen G.D. et al (1985), Acta Pharmacol. Toxicol., 57,|106-116.
FMC Corporation, Material Safety Data Sheet: Sodium|persulfate (02-02-01: date approved), 2001.
Ax, R. L. et al.: J. Reprod. Fertil. 47, 235-238 (1976);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Starratt, A.N., Bond, E.J., 1988. In vitro methylation of|DNA by the fumigant methyl bromide. J. Environ. Sci. Health,|23(5):513-524.
Hermansky, S.J., Chun, J.S. and Loughran, K.A. (1991),|"Caprolactone: Two-Week Drinking Water Study in|Sprague-Dawley Rats", Bushy Run Research Center, Report No.|54-40
Roche (2000) MSDS, Safety Data Sheet Linalyl Acetate from 7.7.2000
Method: other: OECD 471 (1983), Fluctuation test
Cognis Deutschland GmbH & Co. KG (2004). Soluble Silicates:|Evaluation of Photodegradation.
Acute toxicity: inhalation, IUC4#21/Ch.5.1.2
Fazekas IG (1953) Endokrinologie 30, 45. Cited in BIBRA|(1993)
Breslin WJ. A pilot prenatal developmental toxicity study of|C.I. fluorescent brightener 220 and C.I. fluorescent|brightener 339 administered via oral gavage to New Zealand|white rabbits. Report Laboratory Study No. 795-002, August|18, 1998. MPI Research, Mattawan, USA.
Poiger T (1994). Behaviour and Fate of Detergent-derived|Fluorescent Whitening Agents in Sewage Treatment;|Dissertation ETH Zürich No. 10832.
Fassett DW (1963). Esters in Industrial Hygiene and|toxicology, ed. by Patty, 2nd. Ed. Vol II p. 1867, as quoted|in Opdyke DLJ, (1976). Fd. cosmet. Toxicol., 14, 745-746.
Batiste-Alentorn M, Xamena N, Creus A, Marcos R (1995)|Genotoxic evaluation of ten carcinogens in Drosophila|melanogaster wing spot test. Experienta 51: 73-76
Genetic toxicity in vivo, IUC4#26/Ch.5.6
Lyman, W.J., W.F. Reehl, and D.H. Rosenblatt. 1990. Handbook of Chemical Property Estimation Methods. American Chemical Society. Washington, D.C.
De Ley J., Kerstner K.: Oxidation of aliphatic glycols by|acetic acid bacteria. Bacteriol. Rev. 28, 164-180 (1964)
Lessner DJ, Johnson GR, Parales RE, Spain JC, Gibson DT|(2002). Molecular characterization and substrate specificity|of nitrobenzene dioxygenase from Comamonas sp. strain JS765.|Appl. Environ. Microbiol. Feb. 2002, 634-641.
Method: other: Molecular characterization
Bevan, C., Tyler, T.R., Gardiner, T.H., Kapp, R.W., Jr., Andrews, L. and Beyer, B.K.
Sangster (1993); cited in: Epiwin Version 3.1,
Short-term toxicity to fish, IUC4#160/Ch.4.1
Committee on updating of occupational exposure limits|(2000). 4-Ethylmorpholine. Health-based reassessment of|administrative occupational exposure limits, Health Council|of the Netherlands (Gezondheidsraad) Vol. 15, OSH/034, 9.
Reported in AIDA (13/11/92) - ALSTOFF INFORMATION Date Bank|from Satory E. et al. (1986). Acta Pharm. Hung.,|56(3):97-108.
Granberg-Oehman, I. et al.: Mutat. Res. 79, 13-18 (1980)
Buccafusco RJ, Ells SJ and LeBlanc GA (1981). Acute toxicity|of priority pollutants to bluegill (Lepomis macrochirus).|Bull. Environ. Contam. Toxicol. 26, 446-452.
Method: other: Methods for Acute Toxicity Test with Fish, Macroinvertebrates, and Amphibians, US EPA
CIBA-GEIGY Ltd. Point Mutation Test with Chinese Hamster Cells V79 (OECD conform). Test material: TK 11 338 (n-Butyltintrichloride). Test No.: 884026. Genetic Toxicology Department. Basle, Switzerland. August 16, 1988.
Martin TM, Young DM (2001) Prediction of the acute toxicity|of organic compounds to the fathead minnow using a group|contribution method. Chem Res Toxicol 14: 1378 - 1385
Dupont de Nemours (1975) In vitro mutagenicity studies of|para- Nitrochlorobenzene. Haskell Lab. Rep.-No. 494-75:|EPA-OTS0557117
Method: other: in accordance with Ames et al., Mutat. Res. 31: 347 (1975), negative, positive controls (2-AA, MNNG, 2-NF, 9-AA), incubation time: 48 hrs
BASF AG, Laboratory of Ecology, 1989, Pruefbericht ueber|eine Untersuchung auf biologische Abbaubarkeit im|respirometrischen Test (EG-Methode), Test No. 388429,|unpublished study, 02 Mar 1989
Method: other: Manometric Respirometry Test according to EEC Directive 79-831 Annex V, Part C, 5.2
Method: other: occlusive application for 24 h
SRC physprop data base www.syrres.com/esc/physdemo.htm.
Method: other: according to Smyth HF (1962), Am Ind Hyg Ass J 23: 95-107, see also freetext ME
NTP (1994).|(http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=|npsearch.ntpstudiesforchemical&cas_no=107%2D18%2D6)
Huntingdon Research Centre. 1991. Amoco Isophthalic Acid|220: Bacterial Mutation Assay. HRC Report No. AOM 2/91617.
Harris J (1990) Rate of hydrolysis. In: Lymann WJ, Reehla WF & Rosenblatt DH (ed.) Handbook of chemical property estimation methods. Washington, D.C., American Chemical Society 7-1-7-48.
Campbell, R. (2008) Rationale for not conducting a|hydrolysis study on Vinyltris(methylethylketoxime) silane,|(CAS# 2224-33-1). Dow Corning Corporation. January 29, 2008.
Nohmi T, Yoshikawa K, Nakadate M, Miyata R, Ishidate M Jr|(1984) Mutations in Salmonella typhimurium and inactivation|of Bacillus subtilus transforming DNA induced by|phenylhydroxylamine derivates. Mutat Res 136: 159-168
Robinson M, Bull RJ, Schamer M and Long RE (1986). Epidermal hyperplasia in mouse skin following treatment with alternative drinking water disinfectants. Environmental Health Perspectives, 69, 293-300.
Groeneveld, A.H.C., Van Dijk, N.R.M. and Van den Berg, G.|(1992), "The acute toxicity of epsilon-caprolactone to the|guppy Poecilia reticulata", Solvay Duphar Int. Doc. No.|56635/19/92
Thompson, C.Z. et al. (1983) Environ. Mutag., 5, 803-811.
Hüls AG (1988b). Mutagenitätsuntersuchung von|Isophorondiamin (IPD) mit Hilfe des Salmonella|typhimurium/Mikrosomen-Mutagenitäts-Tests nach Ames. Report|No. 88/192 (unpublished).
Method: other: Ames, B.N. et al. (1975). Mutation Research 31, 347-364
Holub, Z. et al.: Biologia (Bratislava), 41, 705-714 (1986), No information
Method: other: Metaphase test, Anaphase-telophase test
Toxicity to terrestrial plants, IUC4#31/Ch.4.6.2
Goldberg ME et al. (1964) Amer Ind Hyg Assoc J, 25, 369.
Nair RS, Johannsen FR, Levinskas GJ, Ben-Duke R (1983)|Changes in hematologic parameters following subacute|inhalation exposure to p-nitroaniline and p-nitrobenzene.|The Toxicologist 3: 64
Method: other: 10 rats/sex/dose exposed to an aerosol (see RM), for further information see freetext ME
Sollmann T (1949) Correlation of the Aquarium Goldfish Toxicities of Some Phenols, Quinones, and Other Benzene Derivatives with Their Inhibition of Autooxidative. Journal of General Physiology, 32:671-679 (cited in BiblioLine(c) 1997-2006, NISC |International, Inc. All Rights Reserved. www.nisc.com).
BASF AG, 1988, Laboratory of Ecology, Oxygen consumption|according to Robra, unpublished study, Study No. 0909/88,|1988
Nalecz-Jawecki G and Sawicki J (1999). SPIROTOX - A new tool|for testing the toxicity of volatile compounds. Chemosphere|38 (14), 3211-3218.
Smith, P.K. Change in blood pigments associated with the prolonged administration of large doses of acetanilide and related compounds. J. Pharm. Exp. Ther. 70, 171-178, 1940
Mirvish, S.S., Williamson, J., Babcock, D., and Chen, S-C. (1993) Mutagenicity of Iso-butyl nitrite vapor in the Ames test and some relevant chemical properties, including the reaction of iso-butyl nitrite with phosphate. Env. Molecular Mutagen. 21:247-252.
Loeser, E.: Bayer AG data, short report, 3. 11. 1978
Bellanca M.A. and Bailey D.S. (1977). Effects of chlorinated|effluents on aquatic ecosystem in the lower James river. J.|WPCF : 639-645.
Shell 1983, Internal Study, Determination of Partition|Coefficient
Toxicity Research Laboratories, Ltd. (1987) "Rat Oral Subchronic Toxicity Study Final Report. Compound: Isobutyl Alcohol." Muskegon, MI. TRL Study #032-002 dated 1987.
Huels AG (1996c). Bestimmung der Auswirkungen von Isophoron|auf das Schwimmverhalten von Daphnia magna, Report No.|DK-318 (unpublished).
Zdzienicka, M.Z. & Simons, J.W.I.M., Prog. Mutat. Res. 5,|583-586 (1985)
Boutwell RK and Bosch DK (1959): The tumor-promoting action|of phenol and related compounds for mouse skin. Cancer Res.|19, 413-424
Method: other: part of NTP genotoxicity program
Gerhartz, W. (exec ed.). (1985), Ullmann's Encyclopedia of Industrial Chemistry. 5th ed. Vol. A1: Deerfield Beach, FL: VCH Publishers, to present.
Grasselli, J.G.; Ritchey, W.M. (1975) Chemical Rubber Company Atlas of Spectral Data and Physical Constants for Organic Compounds, 2nd edition. CRC Press, Inc., Cleveland, Ohio (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com)
Bayer AG, department of toxicology: unpublished results,|report no. 15935, 07-20-87, No information
Zeiger E. et al. (1987). Environ. Mutagen., 9, Suppl. 9, p. 1-110.
Method: other: Haworth, S. et al.: Environ. Mutagen. 5, Suppl. 1, 3-142, 1983
Mirsalis J, Tyson K, Beck J, Loh F, Steinmetz K, Contreras|C, Austere L, Martin S, Spalding J (1983) Induction of|unschedule DNA synthesis (UDS) in hepatocytes following in|vitro and in vivo treatment. Environ Mutagen 5: 482
Escherichia coli WP2, WP2uvrA, CM891, ND-160, MR2-102
OSPAR (2005). OSPAR Background Document on Triphenylphosphine. OSPAR Commission. Hazardous Substances Series. ISBN 1-904426-18-2.
Hoechst AG. 1988.: Butyldiglykolacetat. Study of the mutagenic potential in strains of Salmonella typhimurium (Ames Test) and Escherichia coli. Report No. 88.0568, dated April 29, 1988.
OECD Guideline 472 (Genetic Toxicology: Escherichia coli, Reverse Mutation Assay)
Method: other: replating method Fox, M. (1975): Mutat. Res. 29, 449-466
Method: other: according to Myers & DePass
Legator, M.S., Bueding, E., Batzinger, R., Connor, T.H.,|Eisenstadt, E., Farrow, M.G., Ficsor, G., Hsie, A., Seed, J.|and Stafford, R.S. (1982), "An evaluation of the|host-mediated assay and body fluid analysis: A report of the|U.S. EPA Gene-Tox Program", Mutation Research 98, pp.|319-374
Garlanda T. and M. Masoero Garlanda (1990). Distribuzione e|trasporto nell'ambiente in funzione delle sue proprietachimico-fisiche. |Distribution in the environment - Environmental Partitioning|Model: a Computer Program
Haderlein SB, Weissmahr KW, Schwarzenbach RP (1996) Specific|Adsorption of Nitroaromatic Explosives and Pesticides to|Clay Minerals. Environ Sci Technol 30: 612 - 622
IRDC (International Research and Developmental Corporation):|Modified teratology study in rats with o-Nitrochlorobenzene,|Report no. ML-82-090A, october 1984 (at the request of|Monsanto Company), EPA-OTS0522332
Method: other: 25 females/group, only one dose
American Industrial Hygiene Association (1958) V.19- 1958|19:205, 1958
Mikhailova TV (1964) Comparative toxicity of chlorous|toluene compounds - benzyl chloride, benzal chloride and|benzotrichloride. Gig Tr Prof Zabol 8: 14 - 19
Carl Roth GmbH & Co. (2000). Safety Data Sheet, formic acid,|update 15 May 2000.
BASF AG, Product Safety, Report on Salmonella typhimurium /|Escherichia coli reverse mutation assay (standard plate test|and preincubation test) with 6-methylhept-5-en-2-one|(methylheptenon), unpublished report, project no.|40M0874/004193, 00/874, 18 April 2002
Salmonella typhimurium strains TA98, TA100, TA1535, TA1537. Escherichia coli WP2 uvrA
DuPont Chem (1982) Eye irritation test in rabbits with|benzene, 1-methyl-4-nitro. January 6, 1982: NTIS/OTS 0572886
Method: other: solid test substance was placed in the concunctival sac of one eye, 20 sec. later one eye was washed, observation: 1 and 4 hrs and at 1, 2, 3 days after treatment
Lide DR (1991). CRC Handbook of Chemistry and Physics 72th|ed. Boca Raton, CRC Press Inc, 4-81.
STN (2003). Database Beilstein as searched by BUA on 22|October 2003. Scientific Technical Network (Karlsruhe).
Method: other (calculated): Solaris V4.67, Advanced Chemistry Development (ACD) Software
Hoechst AG (1988): Unveröffentl. Unters. (Ber.-Nr. 88.0459)
Kondo R, Nishijima T, and Hata Y (1995). Kinetic study on|the mineralization of low molecular fatty acids in an anoxic|marine sediment. Fisheries Science 61(3), 482-486.
Leifer, Z., Kada, T., Mandel, M., Zeiger, E., Stafford, R.|and Rosenkranz, H.S. (1981), "An evaluation of tests using|DNA repair-deficient bacteria for predicting genotoxicity|and carcinogenicity: A report of the U.S. EPA Gene-Tox|Program", Mutation Research 87, pp. 211-297
Yoshioka, Ose, Sato (1985): Sci. Total Environ. 43, 149-157
Genetic toxicity in vivo, IUC4#62/Ch.5.6
FDA (Food and Drug Administration) (1974). Teratologic|evaluation of FDA 71-841 (sodium carbonate) in mice, rats|and rabbits, PB-234868.
BASF AG, Department of Product Safety, Laboratory of|Ecology, Prüfung der biologischen Abbaubarkeit von|2-Methylhepten-2-on-6 im manometrischen Respirationstest,|unpublished study, 95/0224/26/2, 28.04.1995 - 26.05.1995
Hoechst AG (1988): Einstufungsbegründung (TA-Luft), Abt. SU|Umwelt/Produktsicherheit (10.08.1988)
Method: other (calculated): Leo, Hansch: Medchem Software CLOGP3, Release 3.42, PomonaCollege, Clermont CA
Bayer AG, Herbold BA (1990) p-Nitrochlorobenzene,|Micronucleus test on the mouse. Report No. 19388, August 8,|1990
"Handbook of Chemistry and Physics" (1986), Chemical Rubber|Publishing Company (Cleveland, Ohio, USA).
postmitochondrial supernatant (PMS) from rat liver
Groten J P, Kuper C F, Schoen E D, van Bladeren P J and|Feron V J. (1994). Subacute toxicity studies of a|combination of nine chemicals in rats: detecting interactive|effects with a two level factorial design. Annual report|1993/1994, TNO Nutrition and Food Research Institute, 93-94., No information
Repeated dose toxicity: inhalation, IUC4#62/Ch.5.4
Spangler, F. and Ward, J.M.: "Skin initiation/promotion|study with formaldehyde in Sencar mice"; in: Clary, J.J. et|al. (eds.): "Formaldehyde, toxicology epidemiology and|mechanisms", Marcel Dekker, Inc.; New York (1983), p.147-158, No information
Gizhlaryan MS, Khechumov SA, Petrosian FR, Kazarian AS, Bal'ian VV (1985). Experimental data on a hygienic standard for 1,4-dichlorobutene-2 in the air of a work area. Gig. Tr. Prof. Zabol. 29 (4), 49-50.
Hansch C et al. (1995) as cited in United States Environmental Protection Agency (2000) Office of Pollution Prevention and Toxics and Syracuse Research Corporation, 2000. EPISuite v3.12 (October 2006).
Human lymphocyte cultures prepared (female)
Ryan, B.M. 1988. Teratological Evaluation of Trimellitic|Anhydride (TMA) in Rats and Guinea Pigs. Submitted in|partial fulfillment of the requirements for the degree of|Master of Science in Biology in the School of Advanced|Studies of Illinois Institute of Technology.
Trabalka JR, Burch MB (1978) Investigation of the Effects of Halogenated Organic Compounds Produced in Cooling Systems and Process Effluents on Aquatic Organisms. In: Jolley RL, Gorchev H, Hamilton DR Jr (Eds.) Water Chlorination: Environmental Impact and Health Effects: pp. 163-173 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Stom DI (1977) Influence of Polyphenols and Quinones on Aquatic Plants and Their Blocking of SH-Groups. Acta Hydrochimica et Hydrobiologica, 5(3):291-298 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Method: other: Determination of the cell division rate, Not performed according to any guideline
CIT (1994) Skin sensitization test in guinea pigs|(Maximization method of Magnusson, B. and Kligman, A.M.) -|Isooctylthioglycolate), Centre International de Toxicologie,|Report no. 10272 TSG, February 1994.
Becker, H., Flade, D. and Weber, K. (2004) TMSPGE:|One-Generation Reproduction Study in the Rat. RCC STudy|Number 850062.
BIA, 2003, Berufsgenossenschaftliches Institut für|Arbeitssicherheit, GESTIS substance data bank choline|chloride, Feb. 2003
SRC Physical Properties database on-line.|http://www.syrres.com/esc/physdemo.htm
Method: other: Calculated by MPBPWIN v.1.41 (2000)
Breslin, W.J., Zablotny, C.L., Bradley, G.F., Lomax, L.G.,|1990b. Methyl bromide inhalation teratology study in New|Zealand white rabbits. Midland, Michigan, The Dow Chemical|Company (Unpublished final report).
Method: other: No specific protocol guideline specified.
Noda A, Kon N (1998a). Reverse mutation test of|dicyclohexylamine on bacteria. Ministry of Health and|Welfare (MHW, Japan) Toxicity Testing Reports of|Environmental Chemicals Vol.6, 101-104, 117-122, 643-646.
Method: other: Guidelines for Screening Toxicity Testing of Chemicals (Japan): Reverse mutation assay in bacteria: pre-incubation method
STN data base Karlsruhe, ACS on STN (2004)
SRC-KOWWIN v1.66, Calculation of logKow (2001)
Haarmann & Reimer GmbH (1980), Menthol flüssig - Akute|Toxizität an Mäusen. Prepared for: 3450 Holzminden, 1-
Zhao Y, Wang L, Gao H, Zhang Z (1993) Quantitative Sructure|- Activity Relationships - Relationship between Toxicity of|Organic Chemicals to Fish and to Photobacterium phosphoreum.|Chemosphere 26 (11): 1971 - 1979
Toxicity to microorganisms, IUC4#180/Ch.4.4
Clariant GmbH 2001: (Project-No. 001114CK) Dr. U. Noack|Laboratorium für Angewandte Biologie (17.01.2001)
Bertens A., 2000, Evaluation of the ability of linalylacetate to induce chromosome aberrations in cultured peripheral human lymphocytes, NOTOX
Genetic toxicity in vivo, IUC4#48/Ch.5.6
Pons, F.W. and Mueller, P.: Mutagenesis 5 (2), 173-177|(1990)
BASF AG, Department of Toxicology: "Prenatal Toxicity of 2-Methyl-1-propanol in Rabbits After Inhalation", BG No.96, Project No. 90R0057/88048, 12.14.1990, conducted under the auspices of the BG Chemie, Heidelberg, (1990); Klimisch H.-J. and Hellwig J.: Fund. Appl. Toxicol., 27, 77-89, (1995).
Alderson, T. and Khan, A. H.: Nature 215, 1080-1081 (1967);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Method: other: repeated dose (21d) dermal toxicity
IITRI. 1992a. Acute inhalation toxicity study of|trimellitic anhydride (TMA) in rats. Final Report. IITRI|Project No. L08100, Study No. 1749, Test Article No. 128L.
Wacker Chemie GmbH (1991) Hazelton Test to Evaluate Abiotic|Degradation-Hydrolysis as a Function of pH-Study No. 104347.
Hose, J.E and Lighter, D.N.; Aquaculture 21, 197 - 201|(1980), No information
Method: other: static exposure in 30 l glass aquaria containing sea water (4 % salinity; 22-24°C)
ALOGP Program (http://www.ihn.unil.ch/Appl/cchem2.html)
Method: other (calculated): ALOGP Program
Breslin WJ. A pilot prenatal developmental toxicity study of|C.I. fluorescent brightener 220 and C.I. fluorescent|brightener 339 administered via oral|gavage to rats. MPI Report No. 795-001, August 18, 1998. MPI|Research Mattawan, USA).
Method: other: exposure time: 6 hours, then cleaning of the treated skin area
Hoechst AG (1977). Hollander H, Mayer D.|Inhalationstoxizität von Phosphortrichlorid an männlichen|und weiblichen SPF-Wistar-Ratten. Report No.: 786/77; 23 Aug|1977 unpublished report.
Kitchin, K.T. & Brown J.L., Toxicology 88, 31-49 (1994)
Genetic toxicity in vivo, IUC4#160/Ch.5.6
Neudecker T. et al (1985), Mutation Research, 157, 145-48.
Tenuta M, Conn KL, Lazarovits G (2002). Volatile fatty acids|in liquid swine manure can kill microsclerotia of|Verticillium dahliae. Phytopathology 92(5), 548-552.
Hoechst AG (1991): Unpublished report (91.0599)
MHW, Japan (1999). Ministry of Health and Welfare, Toxicity|Testing Reports of Environmental Chemicals, 7, 667-676. |(The reproductive /developmental toxicity screening test was|performed by the Mitsubishi Chemical Safety Institute Ltd.)
human and rat epithel cells of the urinary bladder
Litton Bionetics Inc. (1975): NTIS/PB 245487
Genetic toxicity in vitro, IUC4#262/Ch.5.5
Miguel A.A.F., Ferreira A.G.M. and Fonseca I.M.A., 2000.|Solubilities of some new refrigerants in water,Fluid Phase|Equilibria, 173 (1), 97-107
Enslein K, Tuzzeo TM, Borgstedt HH, Blake BW, and Hart JB|(1987). Prediction of rat oral LD50 from Daphnia magna LC50|and chemical structure. In Kaiser KLE (ed.): QSAR in|Environmental Toxicology 11, 91-106. D. Reidel Publishing|Company.
Kim, C.-Y. et al.: Korean J. Toxicol. 7, 61-71 (1991), No information
Meylan, W. and PH Howard. 2000a. User's Guide for AOPWIN,|Version 1.90. EPIWIN (Estimation Program Interface for|Windows) version 3.10. U.S. Environmental Protection Agency,|2000.
Funasaka, R., Y. Ose, and T. Sato (1976) Studies on the|Offensive-Odor Fish of the Nagara River. VII. Median|Tolerance Limit Test of the Offensive-Odor Substances.|Journal of Hygienic Chemistry, 22(1): 20-23.
Munday, E.B. Mullins, J.C. and Edie, D.D. 1980. Vapor|pressure data for toluene, 1-pentanol, 1-butanol, water and|1-propanol. K. Chem Eng Data 25: 191-4
Covance Laboratories (1998). LHS-Super: Acute oral toxicity|study in the mouse. Unpublished final study report No.|1516/7-1032 dated January 1998. Sponsored by Hydro|Nutrition, Oslo.
Method: other: Kuroki, T. et al. (1977): Cancer Res. 37, 1044-1050
Bayer AG (1973). Kimmerle G. Blankophor BBH. Letter to Dr.|Schoenol dated 1973-03-09.
Thurnherr, T. et al., A comparison of acute and long-term effects of industrial multiwalled carbon nanotubes on human lung and immune cells in vitro
Exp Supporting Genetic toxicity in vitro.008
Short-term toxicity to aquatic invertebrates, IUC4#38/Ch.4.2
Hillbom M.E. et al.: Res. Comm. Chem. Pathol. Pharmacol., 9,177-180, (1974) as cited in IUCLID.
Method: other: observation period: 14 days, evaluated according F.H.S.A. = Federal Hazardous Substances Act
Waggy 1988. Union Carb. Corp. DOC I.D. 86-880000325, NTIS/OTS 0516476
BASF AG, Sicherheitsdatenblatt Natriumsulfit wasserfrei P|mind. 98 % Na2SO3 (7/92)
Method: other: OECD TG421; preliminary reproduction toxicity screening, see freetext ME
Berufsgenossenschaft der chemischen Industrie,|Triethylenediamine Subacute (28-day) Repeated Dose|Inhalation Toxicity Study in Rats, APCI RRRS EXT-03/015, 11|Oct 1993
Bringmann G and Kuehn R (1971). Biologischer Abbau von|Nitrotoluolen und Nitrobenzolen mittels Azotobacter agilis.|Gesundheits-Ingenieur 9, 273-276.
Method: other: 2 stage model by Bringmann and Kuehn (1971). Simulation of a munition industrial sewage treament plant
Longstaff E (1978). The sebaceous-gland test. Br. J. Cancer|37, 944-948.
Method: other: sebaceous gland test, see freetext ME
Hagiwara, A. et al. (1989): J. Toxicol. Pathol. 2, 33 - 39
Atofina (2001) Preliminary prenatal developmental toxicity|study by oral route (dietary admixture) in rats. CIT report|no. 20015 RSR.
Method: other: Phytotoxicity Test on a dicotyledonous plant species (Brassica rapa)
Pitter,P., Water Research 10, 231-235, (1976)
Method: other: Biological degradation test / Batch-system
Ciba-Geigy Ltd., Long-term feeding of TK10044 to rats,|CBG26/74398; 8.7.1974.
Streit, B. (1991): Schweflige Säure. In: Lexikon|Ökotoxikologie, 1st Ed. VCH Verlagsgesellschaft mbH,|Weinheim (Germany).
BASF AG (1998). Intermediates - Brochure on Biodegradability|of N-Methylpyrrolidone. Available online at|http://www.basf.com/businesses/chemicals/diols/pdfs/nmp_broc|hre_biod.pdf.
Method: other: German Industrial Standard DIN 38 412, Part 25 (Zahn-Wellens static test)
Garman, R. Bevan, C., Burleigh-Flayer, H., Gardiner, T., Kapp, R., Neptun, D., Tyler, T. and Wright, G.
Ishidate M. et al. (1988). Mutation Res. 195, 151
Ferron GA, Kreyling WG, Fürst G, Neuner M, Schumann G,|Heyder J (1990) LOng-term exposure of dogs to a sulphite|aerosol: III. Effect of lung clearance. J Aerosol Sci -21,|Suppl 1: S479-S482
Method: other: specific investigation of effect of sulfite on macrophage-mediated long-term particle clearance
Harry, H.W. & Aldrich, D.V.(1963): The distress syndrome in|Taphius glabratus (say) as a reaction to toxic|concentrations of organic ions. Malacologia 1(2), 283-289
Clark, C. R., et al., Toxicological Assessment of Heat|Transfer Fluids Proposed for Use in Solar Energy|Applications, Toxicol. Appl. Pharmacol., 51, 529-535, 1979|(87).
Method: other: calculated with Solaris V4.67, Advanced Chemistry Development (ACD) Software
Nonaka, M., Environ. Mol. Mutagen. 14, 143 (1989)
Malten, K. E. et al.: Contact Dermatitis 11, 1-10 (1984)
Method: other: comparable to OECD Guideline 471
Cohen, L.A. et al. (1986): J. Natl. Cancer Inst. 76, |721 - 730
Daniel, F. B., Ringhand, H. P., Robinson, M., Stober, J. A.,|Olson, G. R., Page, N. P. (1991). Comparative subchronic|toxicity of chlorine and monochlorine in the B6C3F1 mouse.|J. Am. Water Works Assoc. 83(11), 68-75.
Method: other: essentially follows OECD 409 Repeated Dose 90-Day Oral Toxicity Study.
Method: other: Respirometry test using a Sapromat
mouse lymphoma cell line (derived from L5178Y)
Vian L, Bichet N, Gouy D (1993) The in vitro micronucleous|test on isolated human lymphocytes. Mut Res 291: 93-102
Method: other: according Fenech and Morley, 1985
Shibata M, Yamada M, Hirose M, Asakawa E, Tatematsu M, Ito N (1990) Early proliferative responses of forestomach and glandular stomach of rats treated with five different phenolic antioxidants. Carcinogenesis 11(3):425-429.
Griffin S, Wyllie SG, Markham J (1999) Determination of|octanol-water partition coefficient for terpenoids using|reversed-phase high-performance liquid chromatography. J|Chromatography A 864: 221 - 228
Shugaev B (1969). Concentrations of hydrocarbons in tissues|as a measure of toxicity, Arch. Environ. Health, Vol. 18,|pp. 878-882.
Short-term toxicity to fish, IUC4#67/Ch.4.1
Priston, R.A.J. & Dean, B.J., Prog. Mutat. Res. 5, 387-395|(1985)
BASF AG, Department of Toxicology, unpublished study |(87/803), 30.05.88
Method: other: Bestimmung der Wirkung von Wasserinhaltsstoffen auf Fische, DIN 38 412 Teil 15
primary cultures of adult rat hepatocytes
Author (1996) Journal of Toxicology, Cutaneous and Ocular Toxicology. Marcel Dekker, Ed., 270 Madison Ave., New York, NY|10016. Vol. 15:261.
Dow Europe SA (1983) "Metaphase analysis of Chinese hamster ovary (CHO) cells treated with DOWANOL* PM", unpublished report.
Method: other: According to Giddings et al. (1983)
Method: other: Standard Operation Procedure PCE/006/04 from GKA Analytik, BASF AG
OECD Guideline 478 (Genetic Toxicology: Rodent Dominant Lethal Test)
Hüttenrauch R., Fricke S. (1982) Die Pharmazie, vol. 37(9): 671
Richterich K and Muehlberg B (2001). Silicic acid, potassium|salt, Fish, acute toxicity. Final Report R-0100924, Henkel|KGaA.
Method: other: DIN 38412/15, part 15 (Golden orfe, acute toxicity test)
Sing, Malik (1988) Proc. Indian Natn. Sci. Acad. B54(6):413-416.
BASF AG (2002). Experimental Toxicology and Ecology. Neurotoxicity study with extended examinations for systemic toxicity and fertility in Wistar rats, unpublished report, Project No. 51C0208/99109, 8 January 2002.
Method: other: OECD No. 408 and EPA OPPTS 870.620, neurotoxicity screening battery
Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1538
Nagasawa, H. and Konishi, R.: Eur. J. Cancer. Clin. Oncol.|23 (7), 1019-1023 (1987);|cited in: RIFM database, location no. 7131
Richardson M.L., Bowron J., J. Pharm. Pharmacol. 37, 1-12|(1985)
Ciba Speciality Chemicals Inc (1989). Microtest Research|Limited (UK) Study to determine the ability of FAT 65´019/H|to induce mutation in five histidine-requiring strains of|Salmonella typhimurium. Addendum to study No. CGC 24/S|reported from Microtest Research Limited to Ciba-Geigy AG|dated 1989-09-20.
NIOSH (2004). International Chemical Safety cards|http://www.cdc.gov/niosh/ipcsneng/neng0315.html.
Covance Laboratories (1996). LHS Super. 7-Day dietary|administration toxicity study in the rat. Unpublished final|study report No. 1516/1-1050 dated December 1996. Sponsored|by Hydro Nutrition, Oslo.
Method: other: Directive 94/40/EC; range finding study
Toxicity to microorganisms, IUC4#130/Ch.4.4
Roche H, Boge G (1996) Fish Blood Parameters as a Potential Tool for Identification of Stress Caused by Environmental Factors and Chemical Intoxication. Marine Environmental Research 41(1):27-43 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Skog, E.: Acta Pharmacol. 6, 299-318 (1950), No information
Vogel AI (1934). Physical Properties and Chemical|Constitution. Part I. Esters of Normal Dibasic Acids and of|Substituted Malonic Acids. J.Chem.Soc. 333-341.
BASF AG (2002). GKA Analytik. Physico-chemical properties,|amendment to final report No. 02L00109, 24 Jun 2002.
Method: other: according to the European Pharmacopeia 1997 edition
Krul, C.A.M. 2002. Tetraoctyltin [CAS # 3590-84-9]: Bacterial reverse mutation [Ames] test. Report V4405/29. Departement of Biomolecular Sciences, TNO Food and Nutrition Research, 3700AJ Zeist, The Netherlands. 19 December 2002.
Cannon Laboratories, Inc. (1974) The effects of Vicinal isomer Mix on the eye mucosa of New Zealand albino rabbits. Reading, PA Report No. 4E-4021. Air Products and Chemical Inc.
FMC Corporation, Repeated insult patch study, Study no.|I95-2037, 1996.
Environment Agency Japan (1994): Investigation on the|Ecotoxicological effects of OECD High Volume Chemicals|(Phase 3): p. 65 - 164.
Method: other: Analogy with the OECD 202 proposal to short-term toxicity tests performed on crustaceans (Daphnia magna) (1979)
Ema, M., R. Kurosaka, H. Amano, and Y. Ogawa. 1995. Comparative developmental toxicity of butyltin trichloride, dibutyltin dichloride and tributyltin chloride in rats. Journal of Applied Toxicology. 15(4):297-302.
Yoshida, K. et al., Non-steady state equilbrium model for|the preliminary prediction of the fate of chemicals in the|environment. Ecotox. Environm. Safety 7, 179-190 (1983)
Hossack DJN, Richardson JC (1976) Examination of the Potential Mutagenicity of Hair Dye Constituents Using the Micronucleus Test. Experientia 33:377-378 (as cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Vasilenko NM, Kovalenko NM (1975) Tr Khar'k Med Inst 124:|32-34; zitiert nach Chem Abstr 89: 191917z (1978)
SRC (1994b). AOPWIN (Atmospheric Oxidation Program for|Microsoft Windows 3.1). Syracuse Research Corporation,|Syracuse, NY.
Method: other (calculated): according to Atkinson (1988); computer program AOPWIN (SRC, 1994 b)
Degussa AG, unpublished, Report No.: Degussa AG, US-IT-Nr.|83-0023-DKT (1983).
Toxicity to soil microorganisms, IUC4#7/Ch.4.4
Horstman, M.G. et al.: The Toxicologist 11, 87 (1991)|(abstr.)
Method: other: 10 mice/sex/group, whole body exposure, body/organ weight, gross and microscopic pathology , statistical analysis; histopathological evaluations on reproductive organs: see chapter 5.8
Method: other: acc. to Smyth et al., Amer. Ind. Hyg. Assoc., 23, 95-107, 1962
ESDU, Engineering Sciences Data, Item Number 71023, Table 1,|Page 5, London, 09/1971, No information
Kuehn, R. et al., UFOPLAN Nr. 106 03 052 des BMU, Maerz 1988
Bogemans, J., Neirinckx, L. and Stassart, J.M. (1989) Effect|of deicing NaCl and CaCl2 on spruce (Picea abies (L.) sp.).|Plant and Soil, 120, 203-211.
Abdernalden's handbuch der biologischen, 4, 1289- (1935)
Malaney GW and Gerhold RM (1969). Structural determinants in|the oxidation of aliphatic compounds by activated sludge.|Journal Water Pollution Control Federation 41(2/2), R18-R33.
Method: other: Warburg method (BOD of THOD)
BASF AG, Department of Toxicology, unpublished study|(80/299), 12.12.80
Method: other: in compliance with Ames B.K.et al., Proc. Nat. Acad. Sci., USA, 70, 2281-2285, (1973) and Mut. Res. 31, 347 -364, (1975)
RCC-NOTOX (1988c): Eye irritation / corrosion study of Benzoguanamine in the rabbit, Study Ref. No. 0913/1141, July 1988
Battelle Europe. 1991. Study on the Ready Biodegradability|(modified Sturm Test) of Trimellitic Anhydride. Study-No: |BE-EA-128-91-01-STT-01.
BASF AG (1970). Department of Toxicology, acute oral toxicity, rat, unpublished report, Study No. XIX/408, 04 August 1970.
Trama, F.B. (1954) The acute toxicity of some common salts|of sodium, potassium and calcium to the common bluegill|(Lepomis macrochirus Rafinesque). Proc. Acad. Natur. Sci.|Philadelphia, 106, 185-205.
Clin. Memo. Econ. Poisons (1956): 1; zitiert in: RTECS|(April 1991)
Auergesellschaft (1998). Auerdata 98 (Database CD),|Auergesellschaft GmbH, Berlin (www.auer.de).
BASF AG (1980). Bestimmung der akuten Inhalationstoxizität|LC50 von Ameisensäure als Dampf bei 4-stündiger Exposition|an Sprague-Dawley Ratten. Unpublished study report dated|August 21, 1980.
Ciba-Geigy Ltd., Report on skin irritation in the rabbit|after single application of (02) TK 10044, Project No|811495, 5.3.1982.
Method: other: Proposed guidelines of the US-EPA §163.81-5 vol 43, no. 163, 1978.
Lewis R. (Ed.), SAX's dangerous properties of industrial|materials, ninth ed., Van Nostrand Rheinhold, 1996 (6)
U.S. EPA (Environmental Protection Agency) (1987). Health|effects assessment for isophorone, Report No. 600/8-88/044.|U.S. EPA, Cincinnati, OH, NTIS PB88-179916.
BASF AG, 2005, Product Safety, data assessment, unpublished|calculation, SRC MPBPWIN 1.41, 15 Aug. 2005
BASF AG, unpublished calculation data; 06. May 2002
Method: other (calculation): according to the program PCKOCWIN v1.66
British Industrial Biological Research Association (BIBRA)
Bringmann, G. and R. Kuehn. 1980. Determination of the|biological effect of water pollutants on protozoa. Part III.|Saprozoic flagellates. Z. Wasser Abwasser Forsch.,13:|170-173.
Topham JC (1980) Do induced sperm-head abnormalities in mice|specifically identify mammalian mutagens rather than|carcinogens. Mut Res 74: 379-387
Method: other: sperm morphology assay according to Topham, Mutation Res. 70, 149-155, 1980
Genetic toxicity in vivo, IUC4#32/Ch.5.6
Salmonella typhimurium TA92, TA1535, TA100, TA1537, TA94 and TA98.
Amoco Corporation (1991). Study on the Ready|Biodegradability (Modified Sturm Test) of Terephthalic Acid;|Conducted by Battelle Europe; Study #|BE-EA-128-91-01-STT-03;
Schering AG. 1993. ZK 24.942. Ready Biodegradability (Closed Bottle Test). Study conducted by Huntingdon Research Centre Ltd., Huntingdon, England. Schering Study Code No. TX 92.265. 23 August 1993.
Method: other: based on OECD Guideline 301D and Directive 84/449/EEC, C.6
Salmonella typhimurium TA1535, TA1537, TA98, and TA100; Escherichia coli WP2 uvrA
Salmonella typh. TA98, TA100, TA1535 and TA1537
Kirk-Othmer Encyclopedia of Chemical Technology. 4th ed.|Volumes 1, New York, NY: John Wiely and Sons,|V7(1991-Present)
Monsanto (year unknown): Unpublished report No. MSL-6158
Method: other: glass walled chamber of 160 l
Method: other: autoradiographic assay, as described by Williams, 1977, Canc Res 37, 1845-51
Cincinnati Milacron Chemicals, Inc. 1971. Acute Toxicity and Irritation Studies on Sample SW-81003. Prepared by Hill Top Research, Inc. Report No. VA-38A.
Method: other: Federal Register, Regulations for the Enforcement of the Federal Hazard Substance Act
NMP Producers Group (1999b) Report: N-Methylpyrrolidone|(NMP) - Two generation reproduction toxicity study in Wistar rats. Administration in the diet. Department of Toxicology of BASF Aktiengesellschaft, Ludwigshafen, Germany, Project No. 70R0056/97008, unpublished study
Method: other: Directive 87/302/EEC, part B 35, p. 47 / OECD 416 / US EPA OPPTS 870.3800
Migchielsen, Ing. M.H.J. and J.M. de Wolf. 2006. Tetrabutylstannane (TTBT): Daphnia magna, reproduction test (semi-static). NOTOX Project 454681. February 14, 2006.
S. typhimurium TA1535, TA1538, TA1537, TA98, TA100
Mobil International (1977). Imlay P. Acute toxicity of MCTR|191-77: Report on primary dermal irritation study in|rabbits. Cannon Laboratories Inc., Edison, NJ, Report No.|7E-6997, Mobil internal report (unpublished report).
El-Nagdy A. et al. Medicolegal aspects of occupational|dermatitis survey in a foam rubber factory, J Egypt Medic|Assoc 56(4-5):331-339, 1973 (10)
Short-term toxicity to fish, IUC4#76/Ch.4.1
Bringmann G and Kuhn R (1959) Comparative Water-Toxicological|Investigations on Bacteria, Algae, and Daphnia. Gesundheits-|Ingenieur 80(4):115-120 (cited in BiblioLine(c) 1997-2006, |NISC International, Inc. All Rights Reserved. www.nisc.com).
Morton International, Inc. 1996. Acute toxicity of monomethyltin trichloride to the marine alga, Skeletonema costatum. Study conducted by T.R. Wilbury. January 26-March 12, 1996.
Salmonella typhimurium TA 100, TA 1537, TA98
Basic Acrylic Monomer Manufacturers. Ricerca, Inc.|Department of Environmental Sciences. Project|Identification No. 88-0207. Painesville, OH. 1990
Schering. 1989. ZK 24.942. Evaluation in the Ames Salmonella/microsome mutagenicity test. Bericht Nr. IC 08/89. 03.03.1989.
Wellens H. (1990) Z.Wasser-Abwasser-Forsch. 23, 85-98
Chinese hamster lung (CHL) fibroblast cells
Roempp (1999). Dicyclohexylamin, Lexikon Chemie - Electronic|Version 2.0, Georg Thieme Verlag, Stuttgart/New York.
Hoechst AG: o-Chlornitrobenzol, Study of the mutagenic|potential in strains of Salmonella typhimurium (Ames test)|and Escherichia coli, unpublished Report No. 84.0410, 1984
Method: other: OECD Guideline 471, rat S9-mix, positive controls
Naylor MW and Thake DC (1987) Three month feeding study of|Santoflex 13 in Sprague-Dawley rats. Study report MSL-6788|of Monsanto Chemical Co. NTIS/OTS 0545431, EPA/OTS document|# 88-920007092 (1992)
Fujimoto K et al. (1985): Occupational pigmented contact|dermatitis from azo-dyes. Contact Dermatitis 12, 15-17.
Method: other: Analogy with the OECD proposal to short-term toxicity tests performed on algae (Scenedesmus pannonicus) (1979)
Zahn,R., Huber,W., Tenside Detergents 12(5), 266-270, (1975)
Method: other: modified OECD-method (TOC, CSB)
Scopas Technology Company (1986). Evaluation of chlorine|dioxide in the in vitro transformation of BALB/3T3 cells|assay Litton Bionetics Inc, report n°= 20992.
EPA OTS 795.2850 (Morphologic Transformation of Cells in Culture)
Grafstrom, R.C. et al: Cancer Res. 44, 4323- 4327 (1984), No information
Genetic toxicity in vitro, IUC4#200/Ch.5.5
Hoechst AG (1977b) Haut- und Schleimhautverträglichkeit von|p-Nitrochlorbenzol an Kaninchen. Unveroeffentl. Unters.|Bericht: 77.0172, 8. März 1977
Method: other: according to: Code of Federal Regulations, Title 16, Section 1500.41 see also freetext ME
Reported in Du Pont - Haskell Laboratory - Internal DMAC|Review, Oct. 1988 from Monsanto Chemical Company,|Unpublished Data:Report No. BDN-75-61, Project 75-1267,|January 7, 1980.
Method: other: 12 animals were exposed to an atmosphere saturated with vapor at 20°C, determination of signs of intoxication and gross autopsy
The Merck Index. 10th ed. Rahway, New Jersey: Merck Co.,|Inc., 1983 , P. 945
Verschueren K (1977) Handbook of Environmental Data on|Organic Chemicals. New York, Van Norstrand Reinhold, p 235
Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538; Escherichia coli WP2 uvrA
Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B and|Zeiger E (1986). Salmonella mutagenicity tests: II. results|from the testing of 270 chemicals. Environ. Mutagen. 8|Suppl. 7, 1-119.
Hardin BD, Schuler RL, Burg JR, Booth GM, Hazelden KP, MacKenzie KM, Piccirillo VJ and Smith KN. 1987. Evaluation of 60 chemicals in a preliminary developmental toxicity test. Terat Carc Mutagen 7:29-48.
RCC-NOTOX (1988d): Primary skin irritation / corrosion study of Benzoguanamine in the rabbit, Study Ref. No. 0913/1140, July 1988
Chan, Hansch: Pomona College (unpublished); 2 cited in:|Hansch, Leo (1985): Pomona College Medicinal Chemistry Data|base.
Becci, PJ; Reagan, EL; Knickerbocker, MJ; Barbee, SJ; Wedig, JH (1983) Teratogenesis study of o-toluenediamine in rats and rabbits. Toxicology and Applied Pharmacology, 71(3):323-9. (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com)
BUA (1993) Resorcinol (1,3-dihydroxybenzol). Beratergremium fur umweltrelevante Altstoffe; Stuttgart, S.; Hirzel Wissenschaft-liche Verlagsgessellschaft, BUA Report 99:1-80.
Method: other: Submerged anaerobic upflow filter
Wikstroem P, Haegglund L, Forsman M (2000). Structure of a|natural microbial mommunity in a nitroaromatic contaminated|groundwater is altered during biodegradation of extrinsic,|but not intrinsic substrates. Microb. Ecol. 39, 203-210.
Method: other: Batch degradation experiments in shake flask
Microbiological Associates Inc. (1989).|Salmonella/mammalian-microsome plate incorporation|mutagenicity assay (Ames test). Unpublished study report|T8864.501 dated 09. 07.1989. Sponsored by Hoechst-Celanese|Corp., Somerville, NJ.
Verschueren K. (1983) Handbook of environmental data on|organic chemicals (2nd Edition) Van Nostrand Reinhold
Massman. (1966) Inst Fuer Arbeitsmedizin der Uni Tuebingen,|1966
Method: other: OECD 415, One-generation reproductive toxicity test
Clayton and Clayton (eds.) (1981) Patty's Ind. Hyg. Toxicol. 2A:2586-2589, 2619-2627.
Method: other: 3 drops of a 1 % solution to the clipped area of the skin for 5 d; on d7 1 drop of the 1 % solution to an untreated area of the skin; reading time not mentioned
Lotrario JB, Woods SL (1997) Comparison of the correlation|of MEP and the free energies of reaction with nitro group|reduction of nitrotoluene congeners. Bioremediation J 1 (2):|115 - 122
Biodegradation in water: screening tests, IUC4#170/Ch.3.5
Takahashi, A. and Ono, H. (1993). Mutagenicity assessment in|44 epxoy resin hardeners in Salmonella typhimurium tester|strains. Chem Express 8:785-788.
Atofina (2001) Prenatal developmental toxicity study by oral|route (dietary admixture) in rats. CIT report no. 20436 RSR.
CIT (Evreux Cedex, France) (2002). Prenatal developmental|toxicity study by oral route (gavage) in rats. Report No.|21318 RSR (unpublished).
Method: other: OECD Guideline 414 (1981)
Method: other: as described by Shelby (1993), Environm. Mol. Mutagen 21, 160-179: 5 rats/group, positive (cyclophosphamide) and solvent control, micronucleated PCE's/1000 PCE's, one-tailed trend test followed by pairwise comparison dose vs. co
National Cancer Institute; Microbiological Associates, Inc.|Hexamethyldisilazane: Mouse Lymphoma assay (L5178Y TK +/-);|Study No. ML-NCI #259; Contract No. N01-CP-05620 (1991)
Jansson K, Hyttinen JMT, Niittykoski M, Mäki-Paakkanen J|(1995) Mutagenicity in vitro of|3,4-dichloro-5-hydroxy-2(5H)-furanone (mucochloric acid), a|chlorine disinfection by-product in drinking water. Environ|Molec Mutagen 25: 284-287
Method: other: according to Maron D. M. and Ames B. N.: Mut. Res., 113, 173-215 (1983)
Fisher (1975) cited in: Etain Cronin, Contact Dermatits,|Churchill Livingstone, Edinburgh, London, New York, 1980,|p. 807
BASF AG (2005). Kalzium Formiat. Material safety data|sheet according to 91/155/EEC, last update 29 Nov 2005.
Chemicals Evaluation and Research Institute (CERI). (2001).|Ready Biodegradation Study on MMB, Report Number 13675.|Unpublished Report.
Yakkyoku Pharmacy 31, 1499 (1980). As cited in: The Registry|of Toxic Effects of Chemical Substances (RTECS). 2-Naphthol.|RTECS# QL2975000. Update July 2000.
Toxicity to terrestrial plants, IUC4#7/Ch.4.6.2
Plitnick LM, Loveless SE, Ladics GS, Holsapple MP, Smialowicz RJ, Woolhiser MR, Anderson PK, Smith C and Selgrade MJK (2005). Cytokine mRNA profiles for isocyanates with known and unknown potential to induce respiratory sensitization. Toxicology 207, 487-499.
Method: other: The boiling point was estimated with EPI Suite version 3.20. The adapted Stein and Brown Method was used.
Schering AG. 1991. Studies on the mutagenic potential of ZK 22.663 in the mouse micronucleus test. Report No. IC 19/90. 21.01.1991.
Bringmann G and Kuehn (1982). Results of toxic action of|water pollutants on Daphnia magna Straus tested by an|improved standardized procedure. Z. Wasser-Abwasser-Forsch.|15 (1), 1-6.
Method: other: immobilisation test according to Bringmann (1978)
Akzo Nobel Chemical (1979): R 6011 (March 1979)
Hayashi et al. (1988). Micronucleus tests in mice on 39 food|additives and eight miscellaneous chemicals. Fd Chem. Toxic.|26, p487-500.
Nelson BK, Setzer JV, Brightwell S et al. 1984. Comparative inhalation teratology of four glycol ether solvents and an amino acid derivative in rats. Environ Health Perspect 57, 261-271.
BEROL NOBEL AB (1994). Environment and Safety Department,|test data communicated to BASF AG, 18 April 1994,|unpublished.
Hoechst AG (1995): Sicherheitsdatenblatt Genamin LA 302 D|(28.02.95)
Sewell IG and McKenzie J (2004) Diammonium Dithioglycolate: Acute toxicity to Daphnia magna. SPL Project No. 1158/050 (Bruno Bock Chemische Fabrik GmbH & Co KG unpublished report).
ICI PLC, 1983, Toxicity to dab (Limanda limanda) of "Choline|Chloride" (75% aqueous solution), unpublished data, report|No BLS/B/0199, 10 June 1983
Marhold J. (1986) Avicenum, p.802 (in RTECS dd 8/3/89).
Huang, G., Z. Bai, S. Dai, and Q. Xie. 1993. Accumulation and toxic effects of organometallic compounds on algae. Applied Organometallic Chemistry. 7:373-380.
Method: other: Rand and Petrocellic (1984)
Mirsalis JC, Tyson CK, Steinmetz KL, Loh EK, Hamilton CM,|Bakke JP, Spalding JW (1989). Measurement of unscheduled DNA|synthesis and S-Phase synthesis in rodent hepatocytes|following in vivo treatment: Testing of 24 compounds.|Environ Molec Mutagen 14, 155-164.
Method: other: mainly according to OECD Guide-line 486
Singh HB et al.: Atmos. Distributions, Sources, and Sinks of|Selected Halocarbon, Hydrocarbons, SF6 + N2O, pp.134 (1979)|USEPA-600/3-79-107.
Ciba-Geigy Ltd., Acute dermal toxicity in the rat test no.|924057, TK 10044 (Irganox 1976), Project No 924057,|22.6.1992.
Epstein, S.S. et al.: Toxicol. Appl. Pharmacol. 23, 288-325|(1972), No information
Daubert TE and Danner RP: PHYSICAL AND THERMODYNAMIC|PROPERTIES OF PURE CHEMICALS: DATA COMPILATION.; DESIGN|INSTITUTE FOR PHYSICAL PROPERTY DATA, AMERICAN INSTITUTE OF|CHEMICAL ENGINEERS. HEMISPHERE PUB. CORP., NEW YORK, NY., 4|VOL. (1989), cited by HSDB 21 Sep 2006
Klaus AM (2004). Isophorondiisocyanat (IPDI) - developmental toxicity study in rats after inhalation. Report No. T7072620 (unpublished). Bayer AG (Wuppertal).
Method: other: OECD TG 414 (2001); 88/302/EEC (1988); U.S. OPPTS 870.0300 (1998); Japanese MAFF guidelines (2000, amended 2001).
Ciba (1989e). Carbon Dioxide Evolution Test for the|Determination of Ready Biodegradability of Metilox (TK|10027). Unpublished report # 894245. November 11, 1989.
Seifert G (1982b). FAT 65'023/L - Acute eye irritation study|in the rabbit. Report GU project No. 820601, November 3,|1982; GU2 Toxicology, Ciba-Geigy Ltd., Sisseln, Switzerland.
Bringmann,G., Kuehn,R., Vom Wasser 50, 45-60, (1978)
Method: other: cell growth inhibition test
BASF AG (1988b). Analytical Laboratory,|1-Octanol-Wasser-Verteilungskoeffizient Pow von|Isobutylidendiharnstoff; unpublished study (BRU 88.154). 03|August 1988 [in German].
Environmental Agency, Japan:(1998) unpublished report on|Fish, prolonged Toxicity Test (No. 91910)
Calame R, Ronchi W., 1989, Linalyl acetate activated sludge, respiration inhibition test, Givaudan
Pellacani (1883), Pharmacology of the camphor group|(Original Title: Zur Pharmakologie der Kamphergruppe). Arch.|Exp.|Path. Pharm. 17, 377, cited in: Schwenkenbecher, A. (1908),|About menthol toxication in human (Original title: Ueber|Mentholvergiftung des Menschen), Muenchner Medizinische|Wochenschrift 55, 1495-1496
Method: other: according to Jansson K. and Hyttinen J. M. T.: Mut. Res., 322, 129-132 (1994)
McCormick, J.H., Env.Pollut.(Series A), 36, 147-163 (1984)
Commission of the European Communities,|Degradation/Accumulation Subgroup; Ring-Test Programme|1981-1982; Assessement of the biodegradability of chemicals|in water by manometric respirometry (1982).
Bio/dynamics Inc. Department of Toxicology. Primary Dermal Irritation Study in Rabbits. Project No.: 4844-88. Test Material 5426-32A. Study conducted for M&T Chemicals, Inc. July 18, 1988.
Method: other: Primary Dermal Irritation Protocols (FIFRA, TSCA)
Elf Atochem (1999) Undecanoic acid, 11-amino; Skin|sensitization test in Guinea pigs (Maximization method of|Magnusson and Kligman). CIT report no. 17553 TSG, 5 March|1999.
Salmonella typhimurium strains TA98, TA100, TA1535, TA1537
Higgins, J.A. & H.A McGuigan. The influence of caffeine on the effects of acetanilide. J. Pharm. Exp. Ther. 49, 466-478, 1933
Menegola E. et al. (1999) , Toxicology in Vitro, 13:|409-415.
BASF AG (1970). Physico-analytical Laboratory, report J.No.|PH 4237, 20 Mar 1970, unpublished.
Method: other: modified method as described by Lee and Webber, 1982
Pilot teratogenicity study of HCFC-124 in the rat. E.I du|Pont de Nemours and Company, Haskell Laboratory for|Toxicology and Industrial Medicines, Delaware, HLR No.,|108-90, September 1990.
Method: other: according to Andreson et al. (1948)
Aaron, C.S. et al.: Mutat. Res. 223, 111-120 (1989), No information
Method: other: modified according Parry and Zimmermann (1976)
Carlton et al. (1991). Reproductive effects in Long-Evans|rats exposed to chlorine dioxide. Environ.Res., 56 p170-177.
Suh DH, Abdel-Rahman MS, Bull RJ (1983). Effect of chlorine dioxide and its metabolites in drinking water on foetal development in rats. Journal of Applied Toxicology, 3(2), 75-79.
Isogai, Komoda, Okamoto (1972): Sci. Pap. Coll. Gen. Educ.,|Univ. Tokyo 22(2), 129-135
Method: other: Bench scale pilot plant test
York M, Griffiths HA, Whittle E, Basketter DA (1996).|Evaluation of a human patch test for the identification and|classification of skin irritation potential. Contact|Dermatitis 34, 204-212.
Hüls AG (1993a). Bestimmung der akuten Wirkungen von|Vestamin IPD gegenüber Fischen. Report No. F 1230|(unpublished).
Author (1993) Toxicologist. Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311. Vol. 13:152
Monsanto Study Nos. PK-82-41 & 47 as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Method: other: Pharmakon Laboratory method
Bengtsson B. E., Renberg L., Tarkpea M. Molecular Structure|and Aquatic Toxicity: an Example with C 1 -C 13 Aliphatic|Alcohols. Chemosphere 13(5/6):613-622. 1984.
Melting point/freezing point, IUC4#13/Ch.2.1
Bayer AG (1992). Internal study: Algal Growth Inhibition|Test of Dicyclohexylamine, GLP-No. 404 A/92 Al.
Method: other: "Algal inhibition test" (C.3) Directive 67/548/EWG (Draft 1992), comparable to OECD TG 201
BASF AG (1998) Salmonella typhimurium/Escherichia coli|reverse mutation assay (Standard plate test and preincubation|test) with neodecansäurechlorid. Project No40M0504/964319.|Unpublished study report dated Dec 15. 1998.
Moffat, A. C. (ed.), Clarke's Isolation and Identification|of Drugs, 2nd ed., London, The Pharmaceutical Press,|420-422 (1986)
Kaiser KLE, Palabrica VS, and Ribo JM (1987). In: Kaiser KLE (ed), QSAR in Environmental Toxicology - II, p. 153-168.
Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E (1983)|Salmonella mutagenicity test results for 250 chemicals.|Environm Mutagen 5[Suppl.1]: 3-142
Method: other: preincubation methodology (PM), rat liver S9-mix and hamster liver S9 mix, solvent: DMSO, solvent and positive controls (2-AA, 4-nitro-o-phenylenediamine, sodium azide, 9-AAD)
Johnson, R.C. and Baillie, D.L.: Genetics 116, 27 (1987);|abstract no. 6.9, No information
BASF AG, Department of Ecology, unpublished data, March 23,|1988
Gupta MM and Dani HM (1986): Efficient prediction of|chemical carcinogenicity by microsomal degranulation.|Toxicol. Lett. 30, 167-172
Salmonella typhimurium (TA100, TA98, TA1535, TA1537); Escherichia coli (WP2uvrA)
Nippon Soda Co., LTD. (1974), unpublished report
Degussa AG, unpublished report, 1990, Acute bacterial cell multiplication inhibition test. Degussa Report No. 90-0041-DGO
Ishidate M Jr. and Odashima S. Chromosome tests with|134 compounds on Chinese Hamster Cells in vitro - a|screening for chemical carcinogens. Mutation Research 48:|337-354, 1977.
Dupont de Nemours (1984) Subchchronic inhalation toxicity|study of p-Chloronitrobenzene in rats. Haskell Lab. Rep.-No.|429-84, december 17, 1984: EPA-OTS0557113 and|EPA-OTS0000455-0
Method: other: 16 rats/dose, head-only exposure, controls to air only additional information: see freetxt ME
Capuzzo, J.M. (1979); The effects of halogen toxicants on|survival, feeding and egg production of the rotifer,|Brachlorrus plicatilus; Est. Coast. Mar. Sci., 8, 307-316.
Short-term toxicity to aquatic invertebrates, IUC4#41/Ch.4.2
Doolittle DJ, Sherrill JM, Butterworth BE (1983) Influence|of intestinal bacteria, sex of the animal, and position of|the nitro group on the hepatic genotoxicity of nitrotoluene|isomers in vivo. Cancer Res 43: 2836-2842
Roshchin AV, Molodkina NN (1977). Chloro compounds of|phosphorus as industrial hazards. Journal of Hygiene|Epidemiology Microbiology and Immunology Vol 21/4, 387-394.
BioDynamics Inc. (1990). Eye irritation studies in rabbits.|Unpublished study report to projects Nos. 5303-88 and|5582-89, dated March 5, 1990. Sponsored by Hoechst Celanese|Corporation, Somerville, New Jersey.
Chemical Industry Institute of Toxicology. [Report prepared|for the CIIT by Battelle Columbus Laboratories, CIIT Docket|No. 109091. CIIT, Research Triangle Park, NC. (1979)].
Method: other: in general conformance with OECD Guide-line 413
Rost, E. et al., Arb. a. d. Kaiserl. Gesundheitsamte 45,|425-490 (1913)
Bushy Run Research Center (BRRC) (1982). Evaluation of the|Dermal Carcinogenicity of|gamma-Glycidoxypropyltrimethoxysilane, Bushy Run Research|Center (BRRC); BRRC Report 45-15, July 8, 1982
EI DuPont De Nemours & CO (1972) Inhalation class poison|study of o,m,p-nitrotoluenes in male CHR-CD rats. March 15,|1972: NTIS/OTS 0557155
Method: other: Test substance was metered into a heated stainless steel tube; air carried the vapors into a 20-liter battery jar; Neither gross nor histopathological examination was performed
Cory-Slechta, D.A. (1986) Prolonged lead exposure and fixed|ratio performance. Neurobehav. Toxicol. Teratol. 8:237-244.
Method: other: DIN 38412 L 11 (Daphnia short-time test)
Stenger, V.A., 1978. Bromine compounds. In: Kirk-Othmer|encyclopedia of chemical technology, 3rd ed. New York,|Chichester, Brisbane, Toronto, John Wiley and Son, vol 4, pp|243-263.
Bartsch W., Acute toxicity of various solvents in the mouse|and rat, Arzneim. Forsch 26(8): 1581-1583, 1976 (32)
Bulgarevich, SB et al. (1991). Conformational investigation of diarylsulphones by Kerr effect and dipole moment methods. Journal of Molecular Structure 249: 365-376.
Method: other: as described by Shelby (1993), Environm. Mol. Mutagen 21, 160-179: 5 mice/group, positive (Cyclophosphamide) and solvent control, micronucleated PCE's/1000 PCE's, one-tailed trend test followed by pairwise comparison dosed vs.co
Stack,V.T.Jr., Industrial and Engineering Chemistry 49, |913-917, (1957)
Heise H, Mattheus A, Schubert H (1997) Vergleichende Testung|verschiedener Gummichemikalien. Dermatosen 45: 226-228
Method: other: Proposal of the German Federal Environmental Agency (UBA), May 1984
Short-term toxicity to fish, IUC4#79/Ch.4.1
Toxicity to reproduction, IUC4#13/Ch.5.8.1
Lefevre PA (1978). The degranulation test. Br. J. Cancer 37,|937-943.
Shahin M.M., (1985): Mutagenicity evaluation of|nitroanilines and nitroaminophenols in salmonella|typhimurium. Int. J. Cosmet.Sci. 7, 277-289.
BASF AG, Technical Data Sheet beta-Ionon R, ME 018 d/e,|08/2003
Koopman, T.S.M. and Pot, T.E. (1986) Primary irritation|study of calcium chloride 33% to the skin of the male|rabbit. Duphar Report No. 56645/31/86.
Wood, L.B., Hurley, B.E.; Matthews, P.J. (1981) Some observations on the biochemistry and inhibition of nitrification. Water Research 15, 543-551
Atkinson, R. Ed. (1990) AOP, Rate of hydroxyl radical and ozone|reaction from chemical structure, Version SRC 1.31,|Syracuse Res. Co. University of California, Riverside, USA
Argus Research Laboratories, Inc.(ARI),(1991). Developmental|toxicity (embryo-fetal toxicity and teratogenic potential)|study of 3-methoxy-3-methyl-1-butanol(MMB) administered|orally via gavage to Crl:CD BR VAF/Plus presumed pregnant|rats, Protocol211-001. Unpublished report
Method: T44-03:Guidelines for Reproduction Studies for Safety Evaluation of Drugs for Human Use(FDA:1966)
Dow Chemical Company (2000) MSDS Aminoethylpiperazine (effective|date 07/03/2000).
Method: other: according Heddle and Salamone, 1980
Colomina,M.; Jimenez,P.; Roux,M.V.; Turrion,C.; Thermochemical Properties of Benzoic Acid Derivatives.; An. Quim.; 82:126-30; (1986)
Tsuda, M., Wakabayashi, K., Hirayama, T., Kawachi, T.,|Sugimura, T. (1983). Inactivation of potent pyrolysate|mutagens by chlorinated tap water. Mutat. Res. Lett. 119(1),|27-34
Ministry of Environment (MOE), Korea(2001), Micronucleus test of acetanilide in Mouse(Test No.257, tested by LGCI toxicology center)
BASF AG, Department of Toxicology, unpublished data on the|prenatal toxicity of Glyecin A in Wistar rats after oral|administration, Report Project No.: 80R0811/89096, 27. Nov.|1995
Sangster J (1989). Octanol-water partition coefficients of|simple organic compounds. J Phys Chem Ref Data 18/3, 1170.
Huntingdon Research Center Ltd.(1989a),Acute oral toxicity|to rats of Solfit. Unpublished report
Tsuchiya, S. et al.: Curr. Prob. Dermatol. 14, 208-219|(1985), No information
Environment Agency of Japan (1999c). Ecotoxicity Testing|Report. Test 92065.
CIT (1993) Acute eye irritation in rabbits with 2-ethylhexyl|thioglycolate, CIT study no. 10267 TAL, 30 december 1993.
CIBA-GEIGY, Ltd. Irritation of TK 11386 in the Rabbit Eye. Project No.: Siss 2844. 16.05.1973.
Battersby, N.S. & Wilson, V., Appl. Environ. Microbiol. 55:|433-439 (1989)
Broderius SJ, Kahl MD, Hoglund MD (1995). Use of joint toxic|response to define the primary mode of action for diverse|industrial organic chemicals. Environ. Toxicol. Chem. 14|(9), 1591-1605
Aeschbacher, H.U. et al.: Fd. Chem. Toxic. 23 (8), 747-752|(1985)
BASF AG, department of toxicology, Bestimmung der akuten|Inhalationstoxizitaet LC50 (4 Stunden) an Ratten (englisch),|unpublished results (88/333), report no. 13I0333/887040,|6-29-89
Method: other: "Verlaengerter Toxizitaetstest bei Daphnia magna (Bestimmung der NOEC fuer Reproduktionsrate, Mortalitaet und den Zeitpunkt des ersten Auftretens von Nachkommen; 21 d) Stand: 01.01.1984"
Anderson, B. (1946): The toxicity tresholds of various|sodium salts determined by the use of Daphnia magna. Seawage|Works J. 18, 82-87
EA, Japan (1994) "Investigation of the Ecotoxicological|Effects of OECD High Production Volume Chemicals", Office of|Health Studies, Environmental Health Department, Environment|Agency, Japan (HPV/SIDS Test conducted by EA, Japan)
Reusche (1989). Hydrolysedaten fuer seitenkettenchlorierte|Stoffe. Bayer Report, 1989-09-21.
Tabershaw I.R., Fahy J.P. and Skinner J.B. Industrial|exposure to butanol. Ind. Hyg. Toxicol. 26:328-331. 1944.
Roehrborn, G. and Buckel, U.: Hum. Genet. 33, 113-119|(1976);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Conaway, C.C., Myhr, B.C., Rundell, J.O., Brusick, D.J.|(1982). Evaluation of morpholine, piperazine and analogues|in the L5178Y mouse lymphoma and BALB/3T3 transformation|assay. Environ. Mutagen. 4, 390.
Bayer AG, Department of Toxicology, unpublished study,|Report Nr. 12557, (1984)
HERA (2004). Human and Environmental Risk Assessment on|Ingredients of European Household Cleaning Products -|Fluorescent Brightener FWA-1 (CAS 16090-02-1). International|Soap and Detergents Association (A.I.S.E.), Brussels; draft|version 2.3 from October 2004; 69 p.
Method: other: Field soil dissipation after application of sewage sludge on soil
Method: other: 2 rabbits, 50 mg/rabbit eye, other rabbit eye sered as control, reading after 2h, 24h, and daily up to 7 days (end of the observation time)
Camargo JA (1991) Bull Env Contam Toxicol, 47, 261-265
Short-term toxicity to aquatic invertebrates, IUC4#26/Ch.4.2
Salmonella typhimurium TA98, TA100 and TA102
Aldrich Chemical Company (1994-1995) Handbook of Fine|Chemicals. Aldrich Chemical Company, Milwaukee, WI
Genetic toxicity in vitro, IUC4#129/Ch.5.5
Method: other: CNS function evaluated according Cherkinskii, 1949: method of conditioned reflexes (time required for appearance, establishment,latent period,magnitude, frequency of occurrence), no further information
WIL Research Laboratories. 1996. Acute Dermal Toxicity Study of Di-n-butyl-oxo-stannane in Albino Rats. Study conducted for ATOFINA Chemicals, Inc. Report ID: WIL-160058.
Salmonella typhimurium TA100, TA1535, TA98, TA1537, E. coli WP2 uvrA
Falk-Petersen et al. (1985): Sarsia 70, 11-16
Method: other: Toxic effects on marine embryos
Method: other (calculated): extrapolated
Marnett, L.J. et al.: Mutat. Res. 148, 25-34 (1985), No information
Chemtura USA Corporation: MSDS for Anox PP 18 (MSDS Number|0034 / Effective Date: 12/31/2005).
Monsanto Chemical Co. (not dated) unpublished study no.|WI-85-304
BASF AG (1984). Department of Analytical Chemistry, report|BRU 84.2, 04 Jan 1984 (unpublished).
Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B and|Zeiger E (1986). Salmonella mutagenicity tests: II. Results|from the testing of 270 chemicals, Environ. Mutagen., Vol. 8|(Suppl. 7), pp. 1-119.
EPA OTS 798.5265 (The Salmonella typhimurium Bacterial Reverse Mutation Test)
detection of back mutations in TA98, TA100, TA1535, TA1537, and TA1538
Ferguson, L.R., Prog. Mutat. Res. 5, 229-234 (1985)
Kurelec, Povse, Rijavec, Japelj, Globokar, Zupet (1972):|Vet. Arh. 42(1-2), 5-11
Daubert, T.E. and Danner, R.P. (1989) Physical and|thermodynamic properties of pure chemicals: Data|Compilation.; Design Institute for Physical Property Data,|American Institute of Chemical Engineers. Hemisphere Pub.|Corp. New York, NY.
Solubility in organic solvents / fat solubility, IUC4#70/Ch.2.6.1
IRDC (1973) Acute Oral Toxicity in Male Albino Rats.|International Research and Development Corporation (IRDC).|Study#: 328-004. Study Date: October 31, 1973.
Reported by Kennedy G.L. (1986) CRC Crit. Rev. Toxicol.,|17:129-182 from Wallen I.E. et al. (1957). Sewage Ind.|Wastes, 29:695.
Huntingdon Life Sciences, A 24-Month Toxicity/Carcinogenicity Study of Tributyl Phosphate in Rats. 1996. Study conducted for the SOCMA TBP Task Force.
Method: other: US EPA/TSCA Guideline No. 798.3320
Boorman, G.A., Hong, H.L., Jamieson, C.W., Yoshitomi, K.,|Maronpot, R.R., 1986. Regression of methyl bromide induced|forestomach lesions in the rat. Toxicol. Appl. Pharmacol.,|86: 131-139.
BASF AG (2005). Safety data sheet according to 91/155/EEC.|FORMIC ACID 99-100%, last update 23 Jun 2005.
Smith, P.J. 1978. International Tin Research Institute (ITRI). Publication No. 538.
Dupont de Nemours (1977) Mutagenic activity of|para-Chloronitrobenzene in the salmonella/microsome assay.|Haskell Lab. Rep.-No. 576-77: EPA-OTS0557119
Method: other: according to Ames et al., Mutat. Res. 31: 347 (1975), cytotoxicity was determined prior to testing, solvent: DMSO, negative- and positive controls (2-AA), incubation time: 48 hrs
Degussa AG, unpublished report, 1990, Acute dermal toxicity rabbit. Degussa Report No. 90-044-DGT
Branch, D.K., T.A. Kaempfe, D.C. Thake, A.A. Li. 1996. Three Month Neurotoxicity Study of Isobutanol Administered by Whole-Body Inhalation to CD© Rats. Lab. Proj. No. EHL 94075, MSL 14525. Monsanto Company, Environmental Health Laboratory, 645 S. Newstead, St. Louis, MO 63110 for the Oxo-Process Panel, Chemical Manufacturers Association. Also reported in Li, A.A., Thake, D.C., Kaempfe, T.A., Branch, D.K., O'Donnell, P., Speck, F.L., Tyler, T.R., Faber, W.D., Jasti, S.L., Ouellette, R., and M.I. Banton. 1999. Neurotoxicity Evaluation of Rats After Subchronic Inhalation Exposure to Isobutanol. Neurotoxicology 20(6): 889-900.
Hexahydromethylphthalic anhydride (MHHPA)
FMC Corp. data, Study no. I89-1102, March 12 (1990)|(at the request of Synthetic Organic Chemical Manufacturers|Association)
Method: other: test according EPA final test rule 1989, Test standard 798.4100
Ullmann's Encyclopedia of Industrial Chemistry, Sixth Edition, 2000 (Electronic Release)
BASF (2002) Calculation of BCF with Bcfwin v2.14. BASF AG,|Product Safety, Regulations, Toxicology and Ecology|12.07.2004 (unpublished data)
Method: other: calucalton Bcfwin, v 2.14
Nunoshiba, T. and Nishioka, H.: Mutat. Res. 254, 71-77|(1991), No information
BASF AG, Laboratory of Ecology, unpublished data, |(1990)
Method: other: similar to OECD TG 301 D Closed Bottle Test
Weber RC, Parker PA, and Bowser M (1981). Vapor pressure|distribution of selected organic chemicals. Industrial|Environmental Research Lab., U.S. EPA, Cinncinnati, Ohio.
Monsanto Study SH-69-10; Food and Drug Research Lab. as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Report No. EDR98002, Environment Agency, Japan (1999c):|unpublished report
BASF AG (1988), unpublished calculations, regression analysis based on measured values and the equation provided by Askonas and Daubert, J Chem Eng Data 33, 225-229, 1988, 2002
Smyth H.F. and Carpenter C.P. J. Ind. Hyg. Toxicol., 30,|63-68 (1948)
Hydrotox GmbH (2001). Closed bottle test of sodium|D-gluconate, according to 92/69/EWG, C.4-E. Study Number|01/1004. Unpublished, sponsored by|Jungbunzlauer S.A., Marckolsheim, France.
Hartke, K., Mutschler, E. (1986), Deutsches Arzneibuch 9.|(Kommentar), 1785-91, Frankfurt.
Ahlstrom, R.C. Jr. and J. M. Steele: Kirk-Othmer|Encyclopedia of Chem Tech., 5, 3rd Ed., 677 (1979).
Feron JP, Anliker R (1976) FAT 65'023: Accumulation and|distribution of FAT 65'023 on Golden Orfe: CIBA-GEIGY AG,|CH-4002 Basel (Switzerland)
FMC Corporation, Sodium persulfate: sensory irritation study|in Swiss Webster mice, Study no. I93-1803, 1994.
Method: other: Standard test method for estimating sensory irritation or airborne chemicals (ASTM standards E981-84)
Repeated dose toxicity: inhalation, IUC4#131/Ch.5.4
Jung, R. et al: Mutat. Res. 278, 265-270, (1992), No information
METI Japan (1995) Ministry of Economy, Trade and Industry (former MITI), test report conducted by Chemicals Evaluation and Research Institute (CERI, Japan) Test No. 21219
Izmerov NF, Sanotsky IV, Sidorov KK (1982) Toxicometric|parameters of industrial toxic chemicals under single|exposure. Centre of|International Projects GKNT, Moscow: p. 47
McGregor, D.B. et al. (1988): Environ. Mol. Mutagen. 11,|91 - 118
Genetic toxicity in vitro, IUC4#273/Ch.5.5
Chiou C, Freed V, Schmedding D and Kohnert R (1977). |Partition coefficient and bioaccumulation of selected|organic chemicals, Environ. Sci. Technol., Vol. 11, No. (5),|pp. 475-478.
Aunaas,T. et al., Comp. Biochem. Physiol. 100C(1/2), 89-93,|1991, No information
Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, and Zeiger E (1986): Salmonella mutagenicity tests: II. results from the testing of 270 chemicals. Environ. Mutagen. Suppl. 8, 1-119.
Citox (2003) Determination of the Abiotic Degradation |(Hydrolysis as a Function of pH): MMP. Study number |24179 PDA. 02 June 2003.
Bayer AG data, Report No. 13805, September 10 (1985)
Hansch C.et al; Exploring QSAR. Hydrophobic, Electoric, and Steric Constantss. ACS Prof Ref Book. Heller SR (consulted) Washington, DC: Amer Chem Soc p 64(1995)
Wilcox, P. et al.: Mutagenesis 5, 87 (1990); abstract no. 62, No information
Amoco Corporation (1993) A Study of the Toxicity to Algae|(Scenedesmus subspicatus) of Terephthalic Acid. Conducted by|Battelle Europe; Study # BE-EA-128-91-02-ALG-3; Referenc
CRC Handbook of Chemistry and Physics. 1995-1996. D.R. Lide (ed.) 76th edition. CRC Press, Inc. Boca Raton, FL p. 3-8.
Hüls AG (1989). Algenwachstumshemmtest nach UBA (Stand Feb.|1984) - Scenedesmus subspicatus. Report No. AW 193|(unpublished)
Method: other: German Umweltbundesamt draft procedure
Repeated dose toxicity: inhalation, IUC4#53/Ch.5.4
EPISUITE v3.10, US EPA/SRC (2000).|http://www.epa.gov/oppt/exposure/docs/episuitedl.htm
Chemicals Evaluation and Research Institute (CERI).|Biodegradation study of octadecyl|3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate. (1996).|Report number: K-1207.
Handbook of Environmental Data on Organic Chemicals, 4th|Edition, Volume II. 2001. p. 1328, John Wiley and Sons.
Hasegawa R. et al.: Jpn. J. Cancer Res., 82, 657-664, (1991)
Hoechst AG (12.03.1991): Interne Mitteilung der Abt.|Produktentwicklung GB-C, Ökologie I
Sondergaard, D. & Olsen, P., Toxicology Letters 10, 239-244|(1982)
Akzo Nobel Chemical (1980): Study report (19.08.1980)
FMC Corporation, Unscheduled DNA synthesis in rat primary|hepatocytes, Study no. I90-1121, 1990.
Meerts IATM (2002): Report Micronucleus test in bone marrow|cells of the mouse with Isophytol. NOTOX Project 349403, 26|June 2002. NOTOX b.v., 's-Hertogenbosch, The Netherlands, on|behalf of F. Hoffmann-La Roche Ltd, Basel, Switzerland,|unpublished.
Method: other: dose range-finding test to an in vivo micronucleus test
Specifications Isophytol technical grade, 23.09.1986, F.|Hoffmann-La Roche Ltd.
Hannuksela M. & Förström L Contact Dermatitis, Vol 2, page|291, 1976.
Kraut K (1871). On the decomposition of phosphorus|trichloride by water. J. Chem. Soc. 158, 660-661.
BASF AG, department of ecology, unpublished data (1282/88),|06.10.1988
Method: other: EEC-guideline 79/831/annex V, part C
Figge, K. and J. Koch. 1973. NATEC, Gesellschaft für naturwissenschaftliche Dienste mbH. Migration of the Methyltin Stabilizer Advastab TM-181-FS from Rigid PVC in the Fat Simulant HB 307. April 1973.
National Institute of Environmental Research (NIER), Korea, The Acute Toxicity of Calcium sulfate dihydrate to Fish(Report No. EG02087, tested by KRICT), 2003
Rosenkranz, S. and Poirier, A.L. (1979), "Evaluation of the|Mutagenicity and DNA-Modifying Activity of Carcinogens and|Noncarcinogens in Microbial Systems", J. Natl. Cancer Inst.|Vol. 62, No. 4, pp. 873-891
USEPA. 2000. MPBPWIN. Version 1.41. Estimation Programs Interface (EPI) Suite. Office of Pollution Prevention Toxics (OPPTS) and Syracuse Research Corporation (SRC).
Woodruff, R. C. et al.: Environ. Mutagen. 7, 677-702 (1985), No information
DeGraeve GM, Geiger DL, Meyer JS, Bergman HL (1980) Acute and embryo-larval toxicity of phenolic compounds to aquatic biota. Archives of Environmental Contaminatin and Toxicology 9:557-568.
BASF AG, Labor Oekologie; unveroeffentlichte Unter-|suchung (1982)
Method: other: respirometric test (BOD of COD)
BASF AG, Product Safety, no titel, unpublished study,|1059/87, 15 March 1988 (secondary quotation)
Rao T.S. et al.: Indian J. Environ. Health, 17,|140-146,(1975)
Genetic toxicity in vitro, IUC4#444/Ch.5.5
Budavari, S. ed., The Merck Index - An Encyclopedia of|Chemicals, Drugs, and Biologicals. 12th ed. Whitehouse|Station, NJ: Merck & Co., Inc., 1996
CIT (2004) Thirteen week toxicity study by oral route (gavage) in rats followed by a four week treatment free period. Study number 26890 TCR, Evreux, France. Study sponsor: L'Oreal.
Bakhishev, G.N., 1973. Relative toxicity of aliphatic|halohydrocarbons to rats. Farmakol. Toksikol., 8:140-142 (in|Russian).
Amoco Corporation (1972) Subacute Feeding Studies (13 Week)|In Rats with Dimethylterephthalate (DMT), Isophthalic Acid|(IA) and Terephthalic Acid (TA). Conducted by Food and Drug|Research Laboratories. FDRL Study #0411
Yaws CL (1994). Handbook of Vapor Pressure. Volume 2 - C5 to|C7 Compounds. Gulf Publishing Company, Houston, Texas.
Zakhari, S. (1978) Toluene diamine, Oral LD50 Results in|Sprague-Dawley rats, Allied Chemical Corporation, Project|No.MA-12-77-8, November 1978.
Genetic toxicity in vitro, IUC4#185/Ch.5.5
Ishidate Jr., M.: Realize Inc., 243 (1983), No information
Genetic toxicity in vitro, IUC4#136/Ch.5.5
Kondo R, Nishijima T, and Hata Y (1995). Kinetic study on|the mineralization of low molecular fatty acids in an anoxic|marine sediment. Fisheries Science 61, 482-486.
Bioaccumulation: aquatic / sediment, IUC4#8/Ch.3.7
Liu D, Maguire RJ, Lau YL, Pacepavicius GJ, Okamura H,|Aoyama I (2000). Factors affecting chemical biodegradation.|Environ. Toxicol. 15(5), 476-483.
Method: other: Batch experiments in cyclone fermentor
Haag H.B., Report "Acute Inhalation Toxicity Studies on|Vapors of GMA Monomer" 2/3/53. National Technical|Information Service (Springfield, VA 22161), Formerly U.S.|Clearing house for Scientific & Technical Information,|OTS0530684.
Daubert, T.E. and Danner, R.P. (1989), "Physical And|Thermodynamic Properties Of Pure Chemicals: Data|Compilation", Design Institute for Physical Property Data, |American Institute of Chemical Engineers. Hemisphere Pub.|Corp., New York, NY., 4 Vol.
Takasago International Cooperation, 1999, Safety Assessment|Lab., Central Research Laboratory, Biodegradability on|beta-ionone, 25 May 1999
Goto S, Ohkubo T, Watanabe E, Endo O, Mochizuki H, Mizoguchi|T, Mineki S, Tanabe K, Matsushita H (1994) Mutagenicity|detection method for volatile compounds using plural|impinging exposure system. J Environ Chem (Kankyo Kaguku) 4:|631 - 636
Method: other: plural impinging exposure system for volatile compounds
Huls Department of Toxicology (1991) In vitro mammalian cell|gene mutation assay (HPRT test) with Dynasylan IBTEO. Report|HP-91/0038 Degussa-Huls AG-Nr.: 91-0251-DGM November 18,|1991
Dow Corning Corporation (1995) Dow Corning Corporation|Internal Report No. 1995-I0000-40075
Allied Signal Inc. (1978). Guinea pig skin|hypersensitization test - isophorone diamine, NTIS/OTS|Microfiche 0515790, Doc 86-870001714.
Method: other: Allied Chemical Corporation Dermal Toxicology Protocol MA-P-03-78
Trevors, J.T. et al., Bull. Environm. Contam. Toxicol. 27,|433-439 (1981)
Method: other: test on growth inhibition
Lashmar, U. T. et al.: J. Pharm. Pharmacol. 41, 118-121|(1989)
Imaizumi, K. et al. (1985), Effect of Essential Oils on the|Concentration of Serum Lipids and Apolipoproteins in Rats,|Agric. biol. Chem. 49, 2795-2796
Bayer AG (1997) Vulkanox 4020 Determination of density and|solubility, unpublished
Method: other: modified OECD Guideline 105 "Water solubility-Flask Method"
Kubota. (1979): Ecotoxicol. Environ. Safety 3, 256-268
Chou W.L., Speece R.E. & Siddiqi R.H., Acclimation and|degradation of petrochemical wastewater components by|methane fermentation, Biotechnol.|Bioeng. Symp., ISS Biotechnol. Energy Prod. Conserv. 8:|391-414, 1978 (97)
Biodegradation in water and sediment: simulation tests, IUC4#6/Ch.3.5
Forbes PD and Urbach F. Experimental modification of|photocarcinogenesis. III. Simulation of exposure to sunlight|and fluorescent whitening agents. Food Cosmet Toxicol 1975,|13:343-345.
Mortelmans K, Haworth S, Lawlor T, Speck W, Trainer B,|Zeiger E, 1986. Salmonella mutagenicity Tests: II. Results|from Testing of 270 Chemicals Environ Mutagen. 8(Suppl 7):|1-119.
Prosolenko NV (1974): Results of a study of the acute|toxicity and cumulative properties of the initial and final|products of azotol production. Tr. Khar'k gos Med Inst.|Vol114. 146-148 (in Russian), as cited by DIMDI, TOXCAS|(TC65), American Chemical Society, 2001
Method: other: Sperm Morphology and Vagina Cytology Examination (SMVCE), see also freetext Test condition
Short-term toxicity to fish, IUC4#61/Ch.4.1
Loeb HA and Kelly WH (1963). Acute Oral Toxicity of 1,496 Chemicals Force-Fed to Carp. U.S.Fish.Wildl.Serv., Sp.Sci.Rep.-Fish.No.471, Washington, D.C.:124.
Tanaka, S. et al. (1990): Eisei Shikenjo Hokoku 108, 52-57
Brooks A.S. and Liptak N.E. (1979): The effect of|intermittent chlorination on freshwater phytoplankton. Water|Res., 13(1), 49-52.
Acute toxicity: dermal, IUC4#30/Ch.5.1.3
Camilleri et al. (1988) J. Chem. Soc. Perkin Trans. 2:1699-1707.
Heisler E and Dickhaus S (1990). Augenreiztest am Kaninchen|mit dem Produkt Betolin K28 -25% in total entsalztem Wasser.|Pharmatox Beratung und Forschung GmbH, Report no. 1-3-37-90.
He F. et al (1985), Giornale Ital. Medic. del Lavoro, 7(1),|5-15.
Method: other: development of neurotoxicity
Method: other: 5 mice/sex/group, whole body exposure, see also freetext ME
BASF AG, 1990, Department of Product Safety, Laboratory of|Ecology, Akute Toxizität für Daphnien nach DIN 38412 L11,|unpublished study, 01/89/1485, 15 Jan 1990
Bosma TNP, te Welscher RAG, Schraa G, Smeenk JGMM, Zehnder|AJB (1990) Microbial Aspects of the Behaviour of Chlorinated|Compounds during Soil Passage. Org Micropollut Aquat|Environ, Proc Eur Supp 6th: 184 - 192
Biodegradation in water: screening tests, IUC4#93/Ch.3.5
Kawachi, T. et al. (1980): Appl. Methods Oncol. 3, 253 - 267
Pincheira, J. and Lopez-Sanchez, J.F.: Mutat. Res. 251 (1),|71-77 (1991);|cited in: RIFM database, location no. 17664
Lo CC and Hsieh TT (2000). Acute Toxicity to the golden apple snail and estimated bioconcentration potential of triphenylphosphine oxide and series of related compounds, Bull. Environ. Contam. Toxicol., 65, p. 104-111.
Chiu C.W., Lee L.H., Wang C.Y., Bryan G.T.(1978),|Mutagenicity of some commercially available nitro compounds|for Salmonella typhimurium: mutat. Res. 58, 11-22
Norris, J.C. and Kintigh, W.J. (1992), "Caprolactone:|Ninety-Day Vapor Inhalation Study on Rats", Bushy Run|Research Center, Report No. 54-94
NTP (National Center for Toxicologial Research): Postnatal|Evaluation of Behaviour and Cardiovascular Function in Rats|Following Daily Oral Caffeine Dosing of Dams Throughout|Gestation, Final Report, NCTR Techn. Rep. for Expt. No. 6189|(1984c)
Developmental toxicity / teratogenicity, IUC4#29/Ch.5.8.2
TA98, TA100, TA1535, TA1537, E. Coli WP2 uvrA
Holmquist, G.U. et al. (1983): Influence of temperature, pH,|water activity and antifungal agents on growth of|aspergillus flavus and aspergillus parasiticus. J. Food Sci.|48(3), 778-782
Method: other: growth inhibition on agar plates
Method: other: according to Ames, B.N. et al.: Mutat. Res. 347-354
Method: other (calculated): XLOGP Program
Petschel R (1991) FAT 65'023/N: Report on analytical|Certificate. CIBA-GEIGY Ltd., CH-4002 Basel (Switzerland),|Test-No. FC-90/30T (not published)
Appearance/physical state/colour, IUC4#11/Ch.1.1.1
Clausen OG and Hegna IK (1977). Determination of the bactericidal and fungicidal effects of alklydimethylbenzylammonium chloride and propyleneglycol-b-phenylether, singly and in combinations. Medd. Nor. Farm. Selsk. 39, 197-204.
Brooks TM, Dean BJ (1981) Mutagenic Activity of 42 Coded|Compounds in the Salmonella/Microsome Assay with|Preincubation. Prog Mut Res 1: 261-270
BASF AG, Department of Product Safety, unpublished data|00/0598/26/1, 28.02.2001
Oldersma, H., A.O. Hanstveit, and J.M. de Wolf. 2003. Trichloromethylstannane (CASRN 993-16-8): Determination of the effect on the growth of the fresh water green alga Scenedesmus subspicatus. TNO Report No. V2492/04. May 2003.
Kanerva, L. et al. (2001), A Multicenter Study of Patch Test|Reactions With Dental Screening Series, Am. J. Contact|Dermat. 12(2), 83-87
CITI (1992). Biodegradtion and Bioaccumulation Data of|Existing Chemicals based on the CSCL Japan, compiled under|the Supervision of Chemical Products Safety Division. Basic|Industries Bureau MITI, CR No. 5-113, 5-5.
Gu. Z. W. (1981) Acta Academiae Medicinae Primae (First Med. Coll.) Shanghai 8 (3), 173-176
Method: other: daily application of TS until death occurred, but max. 20 doses, evaluation of blood chemistry
Elf Atochem S.A. (1995b) Centre d'application de|Levallois.Thioglycolate de 2-ethylhexyle;Détermination de|l'inhibition de la croissance des bactéries Pseudomonas|putida. Etude n° 95/SAEk/1385/AMP
Muller, J. et al., Absence of Carcinogenic Response to Multiwall Carbon Nanotubes in a 2-Year Bioassay in the Peri-toneal Cavity of the Rat
Hoechst AG (1975) Wirkung von Nitro-o-dichlorbenzol-4,1,2|auf das Blutbild weiblicher Katzen (unpublished report no.|502/75). Hoechst AG, Frankfurt
IIT Research Institute. 1985. Primary Eye Irritation Study|of IPA-99 In Rabbits. Study No. 869
LEO, A.J. (1978) Report on the calculation of octanol/water|log P values for structures in EPA files . In ISHOW|database.
Method: other (calculated): ISHOW database
Pellmont. unpubl. rep. cited in National Technical|Information Service (PB-298383), FDA, April|1979
Hansch, C. and A. J. Leo, Med. Chem. Project Issue No 26|Claremont, CA, Pomona College (1985)
Method: other: calculation after Lyman et al. (1990)
Bercz et al. (1982). Subchronic toxicity of chlorine dioxide and related compounds in drinking water in the non human primate. Environ.Health Perspec., 46 p47-55
Mesch, K.A. and T.G. Kugele. 1992. Use of Organotin Stabilizers - Risk Assessment Analysis. Journal of Vinyl Technology. 14(3):131-134.
Method: T31-18:method described by Kada
Syracuse Research Corporation. 2000. KowWin (Log Kow) Log P Calculation. SRC Environmental Science - Interactive Log Kow (KowWin) Demo. http://esc.syrres.com/interkow/interkow.exe?CAS=54849-38-6&sut=Submit+CAS (accessed August 17, 2000).
KOWWIN, v1.67. Log Octanol-Water Partition Coefficient. EPISUITE Version 3.10. Syracuse Research Corporation. Syracuse, NY.
Method: other (calculated): Atom/fragment contribution method; KOWWIN
CIBA-GEIGY, Ltd. 1983. Salmonella/Mammalian-Microsome Mutagenicity Test. Project No. 830523. 06.10.1983.
Method: other: Ames, et al. (1973a,b; 1975)
KEMI Report No. 11/94. 1994. Mono- and Di- Substituted Organotins Used as Plastic Additives. L. Freij (ed.). Volume 1. Environmental Hazard Assessment. The Swedish National Chemicals Inspectorate. p. 14.
Blackburn, G.R. et al.: In Vitro Toxicol. 4, 121-132 (1991), No information
Genetic toxicity in vitro, IUC4#304/Ch.5.5
Haarmann & Reimer GmbH (1980), menthol fluid (RF Menthol),|medical report, Prof. Dr. Stüttgen; 18.04.1980
Farr C.H. (1985), Teratology study in rats with|o-nitroaniline: Unveröffentlichte Ergabnisse der Monsanto|Chem. Co., Sanget
Method: other: pilot teratogenicity study in rats
NTP (National Center for Toxicologial Research): 90 Day|Subchronic Report On Caffeine in Fischer 344 Rats, Final|Report, NCTR Techn. Rep. for Expt. No. 384 (NTP Expt. No.|05011-04) (1983)
BASF AG, 2004, Product Safety, beta-Ionon R - Determinaiton|of the acute effect on the swimming ability of the water|flea Daphnia magna STRAUS, unpublished study,|50E0449/023002, 19 Aug 2004.
Elf Atochem S.A. (1995) Centre d'application de Levallois.|Thioglycolate d'isooctyle; Détermination de l'inhibition de|la croissance des bactéries Pseudomonas putida. Etude n°|95/SAEk/1382/AMP
Hart, WF et al. (1962). 3,3'-Sulfonylbis(phenyl Isocyanates). J. Org. Chem. 27: 338-340.
Cohen, A.: C. R. Acad. Sci. 275, 921-924 (1982);|cited in: Bruehl, E.M. and Einbrodt, H.J.; Wissenschaft und| Umwelt 3/1987, 167-170 (1987), No information
Method: other: acute inhalation screening test
Method: other (calculated): Leo, A.: CLOGP-3.54 MedChem Software 1989. Daylight, Chemical Information Systems, Claremont, CA 91711, USA
Moriyama IS, Hiraoka K, Onishi Y, Yamaguchi R (1976). Effect|of FBA 260 on the pregnant rat. Teratology 14, 247.
Method: other: the rats were exposed via inhalation to p-chloronitrobenzene for 5 months; test concentration: 0.000008 mg/l (a concentration which has a minimal toxic effect), control group
HOECHST AG, Abt. UWS, Abwasserforschung, REPRINT OF AN|EXISTING TEST REPORT from 1979, (22.05.92)
Dow Corning Corporation Internal Report Number|1981-I0005-830
Kuroda, K. et al.: Seikatsu Eisei 3 (1), 15-23 (1989);|cited in: RIFM database, location no. 10155
Genetic toxicity in vitro, IUC4#83/Ch.5.5
Method: other: 0.5 ml undiluted, exposure: 24 hrs
BASF AG, 2003, Product Safety, data assessment, unpublished|calculation, SRC KOWWIN 1.66, 4 Dec. 2003
human lymphocytes co-cultured with intact rat hepatocytes
Unpublished data of Union Carbide (1957) UCC lab notebook (1957).
Method: other (measured): essentially follows OECD 104
Murin,M. et al., Chemosphere, Vol. 34, no. 1, pp. 179-190,|1997
Geiling and McLean (1941), cited in Environmental Health|Criteria 21, WHO (1982)
Hoechst AG (1983): Unpublished study. BONS TTR. Prüfung auf|akute dermale Reizwirkung / Ätzwirkung am Kaninchen (in|German) (Ber.-Nr. 83.0506), 29 Sep 1983
Stott, WT et al. (1992). The evaluation of hepatic cellular proliferation and P450 induction in B6C3F1 mice and Fischer 344 rats exposed to Propylene glycol monomethyl ether.Unpublished report of The Dow Chemical Company.
Bayer AG (1984) Acute toxicity of Vulkanox 4020 to|Brachydanio rerio. Unpublished study, WV-LE,|Umweltschutz/AWALU
Klecka,G.M., Landi,L.P., Chemosphere 14(9), 1239-1251, 1985, No information
Method: other: Respiration Inhibition Test (OECD)
Cumming, R.B. et al. (1986): ORNL Biology Div. Annu. Rept.,|ORNL-5195, June 30, 20-22
IITRI 1989a. Respiratory Sensitization Screen of Trimellitic|Acid (TMLA) in rats. Final Report. IIT Project No. L800,|Study No. 1422, Test Article No. 228C.
Atochem NA. 1991. Dibutyltin chloride: assessment of clastogenic action on bone marrow erythrocytes in the micronucleus test. Report No. 91/0357. Prepared by Life Science Research, Ltd. 08.11.1991.
Sternbach, B. and MacDiarmid, A.G. (1959) The Preparation of|Methoxysilanes by the Interaction of Monosilane and|Methanol. J. Amer. Chem. Soc., 81, (1959) 5109.
Method: other: OECD Guideline 408 "Subchronic Oral Toxicity - Rodent: 90-day Study"
Mutagenicity testing of HCFC-124 in the Salmonella|Typhimurium plate incorporation assay, E.I. du Pont de|Nemours and Company, Haskell Laboratory for Toxicology and|Industrial Medicine, Newark, USA, HLR No. 191-90, September|1990. ||Malley, L.A., Frame, S.R., Elliott, G.S., Bentley, K.S.,|Brock, W.J., Trochimowicz, H.J. and Rusch, G.M. Chronic|toxicity, oncogenicity, and mutagenicity studies with|chlorotetrafluoroethane (HCFC-124). Drug and Chem Toxicol,|Vol 21 (4), 417-447, 1998
Method: other: EPA OTS 798.5265 and OECD guideline 471
Lide D.R. (ed) (1999- 2000) CRC Handbook of Chemistry and Physics, 80th ed. CRC Press. New York, NY. USA. p 3-37 No. 1276.
Santucci, B. et al. (1987), Contact dermatitis to|fragrances, Contact Dermatitis 16, 93-95
Tripathi et al. (1984) Trop. Pest Manage. 30:440-443.
Cronin MTD, Manga N, Seward JR, Sinks GD, Schultz TW (2001)|Parametrization of Electrophilicity for the Prediction of|the Toxicity of Aromatic Compounds. Chem Res Toxicol 14:|1498 - 1505
Schmidt RJ and Chung LY (1992) Biochemical responses of skin|to allergenic and non-allergenic nitrohalobenzenes. Arch|Dermatol Res 284: 400 - 408
Li, A.P., A.R. Dahl, and J.O. Hill. 1982. In vitro cytotoxicity and genotoxicity of dibutyltin dichloride and dibutylgermanium dichloride. Toxicology and Applied Pharamcology. 64:482-485.
Kanematsu, N., Hara, M. and Kada, T. (1980) Rec assay and|mutagenicity studies on metal compounds. Mutation Res., 77,|109-116.
Kubo I., Muroi H. and Himejima M., 1992, Antimicrobial|activity of green tea flavor components and their|combination effects, J. Agricult. Food Chem. 40, 245-248
Method: other: determination of MIC by the broth dilution method
Toxicity to terrestrial plants, IUC4#37/Ch.4.6.2
ABC Laboratories. Acute Toxicity of TBP to Daphnia Magna.|Study ID: AB-78-1384337-1a. Monsanto study AB-79-0150. |(1978)
Method: other: method similar to OECD 202
Salmonella Typhimurium 1535, 100, 1537, 1538, 98
CIBA-GEIGY Ltd. 1982. Report TK 12079. Acute Oral LD50 in the Rat. GU Project No.: 811865. 20.03.1982.
Wild D, King MT, Eckhardt K, Gocke E (1981) Mutagenic activity of aminophenols and diphenols, and relations with chemical structures. Mutation Research 85:456.
Fish PA, Webster DA and Stark BC (2000). Vitreoscilla|hemoglobin enhances the first step in 2,4-dinitrotoluene|degradation in vitro and at low aeration in vivo. J.|Molecular Catalysis B: Enzymatic 9(1-3), 75-82.
Method: other: shake flask degradation experiments
Mitsumori, K., Maita, K., Kosaka, T., Miyaoka, T., Shirasu,|Y., 1990. Two-year oral chronic toxicity and carcinogenicity|study in rats of diets fumigated by methyl bromide. Food|Chem. Toxicol., 28:109-119.
Toze S, Patterson B, Zappia L, Power T, Davis GB (1999) The|effect of sorption and biodegradation on the migration of|munition compounds in groundwater and soil environments. In:|Proceedings of the Contaminated Site Remediation Conference,|Contaminated site remediation: Challenges posed by urban and|industrial contaminants, Freemantle, pp 375 - 381
Waggy, G.T. (1992) Aquatic toxicity data on|aminoethylpiperazine. Unpublished UCC report.
Adler, I.D. and Roehrborn, G.: Humangenetik 8, 81-85 (1969);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Dubreuil, A. et al.: Europ. J. Toxicol. 9, 245-250 (1976), No information
Huels AG (1996b). Bestimmung der akuten Wirkungen von|Isophoron gegenüber Fischen. Report No. F 120|(unpublished).
Basic Acrylic Monomer Manufacturers. WildLife International|Ltd. Project Report No. 408E-102. Easton, MD. 1995.
BASF AG (1975). Department of Technical Engineering, J.No.|9-540, 05 May 1975, unpublished.
Pincheira J. et al. (1988). Mutation Res. 199, 159
Kuehn R and Pattard M (1990). Results of the harmful effects|of water pollutants to green algae (Scenedesmus subspicatus)|in the cell multiplication inhibition test. Water Research|24 (1), 31-38.
Method: other: Cell multiplication inhibition test acc. to DIN 38412, part 9, modified
Huisgen R, Brade H, Walz H and Glogger I (1957). Mittlere|Ringe VII, Die Eigenschaften aliphatischer Lactame und die|cis-trans-Isomerie der Säureamidgruppe. Chem. Ber. 90,|1437-1447
Bayer AG data, Report No. 19799, 12. 12. 1990
O`Neil MJ, Smith A, Heckelman PE, Budavari S, (Editors)|(2001). The Merck Index (13th Edition), Merck & Co., Inc.|Whitehouse Station, NJ.
Method: other: calculated with PCKOCWIN v1.66
BASF AG (1992). Department of Physical Chemistry, water solubility, Unpublished Report, Report No. UV 1.92, 15 October 1992.
Method: other: Directive 67/548/EWG, A. VII and VIII, part A6
The Sigma-Aldrich Library of Regulatory and Safety Data.
Method: other (measured): not specified
JETOC (Jap Chem Ind Ecolog Toxicol Inform Center) (1997)|Mutagenicity Test Data of Existing Chemical Substances|[Supplement]: 33-39, 244-246, February 1997
Method: other: preincubation method according to Ames, Mutat. Res. 31,347 (1975); Maron, Mutat. Res.113, 173 (1983); highest doses used: cytotoxic, positive controls, solvent (DMSO) control (see also freetext ME)
BASF AG. Physico-analytical Laboratory, report J.No. PH|6295, (date not stated).
E I Du Pont De Nermours & Co. 1984. Acute inhalation toxicity of 2-(2-butoxyethoxy)ethyl acetate (butyl carbitol acetate). Submission to EPA with cover letter, unpublished study. OTS 84003A.
Method: other: NTP-Carcinogenicity Study
Verschueren, K., Handbook of environmental data on organic|chemicals, 2nd Ed., Van Nostrand Reinhold Company, p. 467|(1983)
Method: other: calculated with WSKOW v1.41
Salmonella typhimurium strains TA1535, TA100, TA98, TA97
International Occupational Safety and Health Information|Centre (CIS) (2005) METHYL ETHYL KETONE PEROXIDE (Technical|product) ICSC: 1028 October 2005. |http://www.ilo.org/public/english/protection/safework/cis/pr|oucts/icsc/dtasht/_icsc10/icsc1028.htm
Method: other: (calculated) Fugacity Level III
Method: other: according to a dutch national standard method: NEN 6501, 1980 (Wateronderzoek. Bepaling van de acute toxiciteit met Daphnia magna)
ELF ATOCHEM: ACIDE AMINO-11 UNDECANOIQUE.Détermination de la|biodégradabilité facile.Unpublished report.October 1994.
BIODEGRADATION AND BIOACCUMULATION DATA OF EXISTING
Salmonella typhimurium TA98, TA100, TA1535 and TA1537
Randall TL and Knopp PV (1980). Detoxification of specific|organic substances by wet oxidation. JWPCF 52(8), 2117-2130.
Method: other: EPA-660/3-75-009 (1975): "method for acute toxicity tests with fish, macroinvertebrates, and amphibians"
Morgan, K.T., Swenberg, J.A., Hamm, T.E., Jr.,|Wolkowski-Tyl, R., and Phelps, M.: Fundam. Appl. Toxicol.|2:293-299 (1982).
Short-term toxicity to fish, IUC4#78/Ch.4.1
Repeated dose toxicity: oral, IUC4#35/Ch.5.4
Seinen, W. and M.I. Willems. 1976. Toxicity of organotin compounds. I. Atrophy of thymus and thymus-dependent lymphoid tissue in rats fed di-n-octyltindichloride. Toxicol. Appl. Pharmacol. 35:63-75.
Huntingdon Life Sciences (2000) Ethyltriacetoxysilane: Acute|Oral Toxicity Study in Rats. Study No. 99-0590. May 15,|2000.
Zhang C, Hughes JB, Nishino SF, Spain JC (2000).|Slurry-phase biological treatment of 2,4-dinitrotoluene and|2,6-dinitrotoluene: Role of bioaugmentation and effects of|high dinitrotoluene concentrations. Environ. Sci. Technol. |34, 2810-2816.
Capuzzo, J.M., Lawrence, S.A., Davidson, J.A. (1976);|Combined toxicity of free chlorine, chloramine and|temperature to stage I larvae of the american lobster|Homarus americanus; Wat. Res., 10, 1093-1099.
Short-term toxicity to aquatic invertebrates, IUC4#45/Ch.4.2
Acute toxicity: inhalation, IUC4#64/Ch.5.1.2
Environment Agency of Japan (1999d). Chronic Toxicity of|5-Ethylidene-2-Norbornene for Daphnia magna. Report 92067.
Ullmann's Encyclopedia of Industrial Chemistry. Release 2001|6th Edition
Method: other: Guideline for the 28-Day Repeated Dose Toxicity Test in Mammalian Species (Chemical Substances Control Law of Japan)
Method: other: see freetext test conditions
BASF (1988): Kaliumsulfit, Wachstumshemmtest in Anlehnung an|Bringmann-Kühn. DUU/OO - A 520. File No. 9/0894/88/w,|22.07.1988
Mouse lymphoma (L5178Y), heterozygous subline, TK+/-
Method: other: single generation of an aerosol (4 ccm in ethanol, 400 l-chamber)
Four-hour inhalation approximate lethal concentration (ALC)|of HCFC-124 in rats, E.I. du Pont de Nemours and Company,|Inc., Haskell Laboratories for Toxicology and Industrial|Medicine, Newark, Delaware, Report No 71-90, 1990
St-Jean, S.D., E. Pelletier, and S.C. Courtnay. 2002. Hemocyte functions and bacterial clearance affected in vivo by TBT and DBT in the blue mussel Mytilus edulis. Mar. Ecol. Prog. Ser. 236:163-178.
Long-term toxicity to aquatic invertebrates, IUC4#12/Ch.4.5.2
Nitschke, K. et al., Unpublished report of The Dow Chemical|Company (acute inhalation) (1990)
Method: other: Hirano et al. (1982). Mut. Res. 97, 339-347
adult rat liver (ARL) cells, line 18, at passage 25
Method: other (measured): derived from boiling points at different pressures
Monsanto Study Nos. SH-82-42 & 48 as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Method: other: aneuploidy screening assay
BASF AG (1988). Department of Analytics, Octanol/Water Partition Coefficient, Unpublished Report, Report No. UV-20.88, 03 November 1988.
Hoechst AG (1980). Unpublished Report, 1980-06-12.
Gautheron P, Dukic M, Alix D, Sina JF (1992) Bovine Corneal|Opacity Permeability Test: An In Vitro Assay of Ocular|Irritancy, Fundamental and Applied Toxicology 18, 442-449
Method: other: in vitro Bovine Corneal Opacity Assay
Temcharoen, P. and Thilly, W.G.: Mutat. Res. 119, 89-93|(1983), No information
Bringmann G (1978). Bestimmung der biologischen Schadwirkung|wassergefährdender Stoffe gegen Protozoen. Z.f. Wasser- und|Abwasser-Forschung 11 (6), 210-215.
Monsanto Study No. BD-81-330 as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Method: other: Bio/dynamics Laboratory method
Biodegradation in water and sediment: simulation tests, IUC4#10/Ch.3.5
Jansson T, Curvalli M, Hedin A, Enzel CR (1986) In vitro studies of biological effects of cigarette smoke condensate. II, Induction of sister chromatid exchanges in human lymphjocytes by weakly acidic, semivolatile constituents. Mutation Research 169:129-139.
Oshima, H. et al. (1991), Epidemiologic study on|occupational allergy in the dental clinic, Contact|Dermatitis 24, 138-139
NPIRI: Raw Mater. Data Handb. Vol. 1, 6 (1974)
Method: other: The method was in principle equivalent to OECD Guideline 414
TSCATS: OTS 0513188, Doc. I.D.: 86-870000238, 02.01.1978, Celanese Chemical Co., Inc.; cited in BG Chemie (ed.): 2-Methylpropanol-1, in: Toxikologische Bewertung, Ausgabe 01/97, BG Chemie, Heidelberg, pp. 3-40, (1997) as cited in IUCLID.
Method: T31-18:Plate incorporation assay with and without addition of S9 mix prepared from liver of Arochlor 1254-induced male SD rats.
Escherichia coli WP2 hcr/Salmonella TA100, 1535, 98, 1537, 1538
Wu, H. Determination of Ready Biodegradability: Closed|Bottle Test|Ethyl Acrylate (EA), Methyl Acrylate (MA), Hydroxyethyl|Acrylate (HEA),|Hydroxypropyl Acrylate (HPA), Butyl Acrylate (BA). Testing|Facility: Roy F. Weston - Fate and Effect Laboratory, 254|Welsh Pool Road, Lionville, Pa. Project Number: 96-016.|Study Date: August 26, 1996.
Monsanto (1983). Coate WB. Subacute Inhalation Toxicity|Study in Rats - Phosphorus Trichloride. Report HL-82-0273;|29 Nov 1983.
Apfelzweig, R.A. and Teplitz, R.L.: Mutat.Res. 62, 151-158|(1979)
Bukhalovskii AA and Shugaev VV (1976). Prom. Sint. Kauck. 2,|4-5.
Fichan I., Larroche C. and Gros J.B., 1999, Water|solubility, vapor pressure, and activity coefficients of|terpenes and terpenoids, J. Chem. Eng. Data 44, 56-62
IBR International Bio-Research (1978b). Akute Inhalationstoxizität von Isophorondiisocyanat "(IPDI)" im Zeitsättigungstest bei der Ratte. Report No. 1-4-79-78 (Veba-Chemie AG, unpublished).
Method: other: Draft version for Directive 84/449/EEC, B.2
Acute toxicity: inhalation, IUC4#44/Ch.5.1.2
Cannon Laboratories, Inc. (1974) The primary irritation study of Vicinal isomer mixture on abraded and non-abraded skin of New Zealand albino rabbits. Reading, PA. Report No. 4E-4019. Air Products and Chemicals, Inc.
Mammalian cell aberration assay in Chinese Hamster Ovary Cells with Confirmation
McClure, H.B.: Newer aliphatic chemicals. Chem Eng News 22,|416-421 (1944)
Bitron MD and Aharonson EF (1978), Amer Ind Hyg Assoc J, 39,|129-138.
BASF AG, Department of Toxicology, Study on the inhalation|toxicity of 3-methylbuten-2-al-1 as a vapor in rats, 28 days|test, unpublished report, project no. 40I0734/90126, 12 Apr.|1994
BASF AG, Analytisches Labor, unpublished results, J.No.|124836/03, 20.05.1988
Method: other (measured): test procedure according to an internal BASF standard, comparable to OECD 107
Matheson gas data book, 1980. The Matheson gas data book. |East Rutherford, New Jersey, Matheson Gas products (A|Division of Will Ross), vol 6, pp 361-363.
Method: other: Directive 87/302/EEC, part B, p. 32, OECD Guide-line 451, EPA OTS 798.3300
Chinese Hamster V79 cells (V79) , Chinese hamster Ovary cells (CHO), HeLa S3 cells (HeLa)
IBT (1975). Acute Dermal Toxicity Study in Albino Rabbits|with Irganox 1300 Paste. Industrial Bio-Test Laboratories,|Inc. Unpublished report # 601-05809. January 7, 1975.
Adams K (2000). 4,4'-Dichlorodiphenyl Sulphone Rat Liver DNA Repair (UDS) Test. Huntingdon Life Sciences Ltd, AOM 015/994710.
Method: other: preliminary experiment for UDS test
Friedman, L. et al.: J. Environ. Pathol. Toxicol. 2, 687-706|(1979); and|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Fadnavis NW, Seshadri R, Sheelu G, and Madhuri KV (2004).|Relevance of Frank's solvent classification as typically|aqueous and typically non-aqueous to activities of firefly|luciferase, alcohol dehydrogenase, and alpha-chymotrypsin in|aqueous binaries. Archives of Biochemistry and Biophysics|433, 454-465.
Skin irritation / corrosion, IUC4#16/Ch.5.2.1
Lopez-Malo, A. et al. (2005): Aspergillus flavus growth in|the presence of chemical preservatives and naturally|occurring antimicrobial compounds. Int. J. Food Microbiol.|99(2), 119-128
Method: other: 13 day range finding toxicity study
Frei JV and Stephens P (1968).The correlation of promotion|of tumour growth and of induction of hyperplasia in|epidermal two-stage carcinogenesis. Brit J Cancer 22, 83-92.
Bertrand, M. et al.: CR Soc. Biol. (Paris) 164, 1488-1489|(1970);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Bringmann G, Kühn R (1980) Comparison of the Toxicity|Thresholds of Water Pollutants to Bacteria, Algae, and|Protozoa in the Cell Multiplication Inhibition Test. Water|Res 14: 231 - 241
Griffiths, A.J.F. in: Short-Term Tests for Chemical|Carcinogens, Chapter 17; pp. 187-199 (1981);|cited in: RIFM database, location no. 29283
Mueller, W.U. et al.: Teratogen. Carcinogen. Mutagen. 5,|123-131 (1985);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Method: other: according Maron and Ames 1983, Levin 1982
Yasuhara, K. et al.: Lack of Carcinogenicity of|Cyanoguanidine in F344 Rats., Food and Chemical Toxicology,|35, 475-480(1997)
AUTHOR (no date specified) Solubilities of Organic Compounds, Volume II, Atherton Seidell, 194.
Bio-Research Laboratories, Ltd. (1980) An Evaluation of the|Potential Toxicity of Inhaled Trimethoxysilane in the Albino|Rat. Report Project 9331. (Prepared for Dow Corning|Corporation) (as cited in BRRC 50-147)
Bayer AG (1984) Biologischer Abbau von Vulkanox 4020.|Unpublished study WV-LE Umweltschutz/AWALU 3.12.1984
Method: other: Respirometer-Test, ISO DP 9408, EG Directive 79/831/ Annex V, modified MITI I Test (OECD 301C)
Allied Corporation (1978) . Evaluation of|[3-Glycidoxypropyltrimethoxysilane] for Enzyme|Mediated Mutagenicity in Salmonella Typhimurium (Allied|Corporation Project No. MA-52).
Hüls AG (1989). Product information and unpublished vapour pressure curve "IPDI - isophorone diisocyanate". Edition 43.03.018e/08.89.
ABC Lab Inc. (1990). Acute flow-through toxicity of sodium|formate to rainbow trout (Oncorhynchus mykiss). Analytical|Biochemistry Laboratories Inc., report No. 38312 for Hoechst|Celanese Corp., 16 March 1990, unpublished.
Hoechst AG (1975a) Akute dermale Toxizität von|4-Chlor-1-nitrobenzol an weiblichen SPF-Wistar Ratten.|Unveroeffentl. Unters. Bericht: 75.0486, 14. Oct. 1975
Method: other: 6 rats/dose, TS bloated in sesame oil, applied on the shaved back, fixed with alu foil and bandage for 24 hours, then washed, observation period: 14 day, pathologic examination, body weight, statistical analysis
BASF AG (1990 b), Department of Toxicology: "Prenatal Toxicity of 2-Methyl-1-propanol in Rabbits After Inhalation", BG No.96, Project No. 90R0057/88048, 12.14.1990, conducted under the auspices of the BG Chemie, Heidelberg, (1990); Klimisch H.-J. and Hellwig J.: Fund. Appl. Toxicol., 27, 77-89, (1995).
Le Curieux, F. and Marzin, D. and Erb, F. (1993): Comparison|of three short-term assays: results on seven chemicals.|Potential contribution to the contorl of water genotoxicity.|Mutation Research, 319, 223-236.
EPIWin Modeling Program (2000) Version 3.11. Developed by the EPA's Office of Pollution Prevention Toxics and Syracuse Research Corporation (SRC). copyright 2000 U.S. Environmental Protection Agency.
Smyth H.F. Jr et al. (1969). Am Ind Hyg Ass J (30) 470.|Cited in BIBRA (1993)
Wagner R., Untersuchungen ueber das Abbauverhalten|organischer Stoffe mit Hilfe der respirometrischen|Verduennungsmethode II. Die Abbaukinetik der Testsubstanzen,|Vom wasser 47: 241-265, 1977 (22)
BOD5 Method: other: respirometric method according to Wagner R. Vom wasser 42: 271-305 (1974)
Zamora, P.O. et al.: J. Toxicol. Environ. Health 12, 27-38|(1983), No information
Method: other: OECD combined repeated dose and reproductive/developmental toxicity screening test
cultured Chinese Hamster lung (CHL) cells
Baglay AK, Gurariy LL, Kuleshov GG (1988): Physical|properties of compounds used in vitamin synthesis. J Chem|Engng Data 33(4): 512-518.
CIT (1993) Acute dermal irritation in rabbits - Isooctylthioglycolate, Centre International de Toxicologie, Report no. 10270 TAL, December 1993.
Rowley, R.L., W. V. Wilding, J. L. Oscarson, Y. Yang, N. A.|Zundel, T. E. Daubert, and R.P. Danner. (2004) DIPPR® Data|Compilation of Pure Chemicals Properties, Design Institute|for Physical Properties, AIChE, New York, NY.
WIL Research Laboratories, LLC (2005) A 14-DAY DOSE|RANGE-FINDING STUDY OF METHYL ETHYL KETONE PEROXIDE IN RATS.|WIL-497003 28 September 2005.
Severes, L. W., 1994. Determination of Methyl Bromide|Solubility in Petroleum-Based Solvents. Unpublished report|from WIL Research Laboratories. WIL-49012.
Method: other: US EPA FIFRA Pesticide Assessment Guidelines, Subdivision D, October 1982, Section 63-8 and 40 CFR, 158.190.
Kirk-Othmer encyclopedia of chemical technology (1992). 4th|Ed., Vol. 2, John Wiley & Sons (New York), p. 388.
Bayer AG (2001). Material Safety Data Sheet to|Dinitrotoluene 65/35 from 2001-11-06.
Poiger T, Field JA, Field TM, Siegist H and Giger W (1998). |Behavior of fluorescent whitening agents during sewage|treatment. Water Res. 32, 1939-1947.
Method: other: Measurements in a sewage treatment plant
Springborn Laboratories, Inc; Acute Toxicity to Water Fleas|(Daphnia magna), Under Static Renewal Conditions in a Closed|System, Following OECD Guideline No. 202, Study Number|13776.6101, (2002).
Microbiol Associates Inc. (1998) Micronucleus cytogenetic|assay in mice: o-toluidine, Lab. Study No. TE344.122054,|January 13, 1998 (at the request of Berufsgenossenschaft der|Chemischen Industrie, Heidelberg)
Method: other: preliminary tests: pilot assay and toxicity test; MN test: according to Hendle et al. (see freetext ME) equivalent to OECD TG 474
Anderson. D. and Styles, J.A.: Mutat. Res. 37 (5), 924-930|(1978);|cited in: RIFM database, location no. 3898
Irmann, F., 1966. Eine einfache Korrelation zwischen|Wasserlöslichkeit und Struktur von Kohlenwasserstoffen und|Halogenkohlenwasserstoffen. Chemie-Ingenieur-Technik,|37(8), 789-798||Maassen, S., 1996. Experimentelle Bestimmung und|Korrelierung von Verteilungs-koeffizienten in verdünnten|Lösungen. Doctoral dissertation D83, Technische Universität|Berlin, 1st September 1995. Published by Shaker Verlag,|Aachen, 1996 (ISBN 3-8265-1104-2)
de Kruif KG, Herman JM and van den Berg PJ (1981). Enthalpies of Vaporization and Vapor Pressures of Triphenyl-, Tri(p-tolyl)-, and Tris(2-cyanoethyl)phosphines, J. Chem. Eng. Data 26, p. 359-361.
Dawson, G.W., Jennings A.L., Drozdowski, D. and Rider, E. The acute toxicity of 47 industrial chemicals to fresh and salt water fishes. J. Hazard. Mater. 1(4), 303-318, 1975/1977
Salmonella typhimurium TA 97, TA 98, TA 100, TA 1535
Chemicals Evaluation and Research Institute (2004).|Dissociation Constant of 4-ethylmorpholine. Report Number|805293.
Repeated dose toxicity: oral, IUC4#17/Ch.5.4
Bayer AG: Inst. of Toxikology, unpublished data, report No.|15879, 26.06.1987
Karegoudar, Pujar. (1985): FEMS Microbiol. Lett. 30, 217-220
Darroudi F. and A.T. Natarajan. Mut. Res. 143, 263-269,|(1985)
Method: other: Verfahren nach Tuempling, im Warburgapparat
Bayer AG (1979). Leuschner F. Pruefung der lokalen|Vertraeglichkeit von Blankophor BA 267 % an der|Kaninchenhaut (Patch-Test). Study reported from Laboratorium|fuer Pharmakologie und Toxikologie to Bayer AG dated|1979-06-07.
Method: other: Federal Register vol. 38, No. 187, 1973
Method: other: Federal Register of August 12 1961, pages 7333-7341
Genetic toxicity in vitro, IUC4#198/Ch.5.5
Fesch C, Haderlein SB (1998) Competitive sorption and|multiple-species subsurface transport of nitro-armatic|explosives: implications for their mobility at contaminated|sites. IAHS Publ 250: 27 - 34
Adsorption / desorption, IUC4#12/Ch.3.3.1
Method: other: Scenedesmus-growth inhibition test
Bringmann, G. und Kuehn, R., Gesundheitsingenieur 80 (4),|115-120 (1959)
Daubert and Danner, 1989 as cited in EPISUITE 2000 US-EPA.
Schmidt TC, Kleinert P, Stengel C, Goss K-U, and Haderlein|SB (2002). Polar fuel constituents: Compound identification|and equilibrium partitioning between nonaqueous phase|liquids and water. Environ. Sci. Technol 36 (19), 4074-4080.
Sasaki, K. et al., Bull. Environ. Contam. Toxicol. 28,|752-759 (1982)
Bioaccumulation: aquatic / sediment, IUC4#40/Ch.3.7
Krul, C.A.M. 2003. Dichlorodioctylstannane [CAS# 3542-36-7]: Micronucleus test in rat bone marrow cells. Report V3404/14. Department of Biomolecular Sciences, TNO Chemistry, 3700 AJ Zeist, The Netherlands. 4 March 2003.
Biodynamic Inc., Project No. 89-3537, January 24 (1991)|(at the request of Synthetic Organic Chemical Manufacturers|Association Inc.).
Bokranz, A. and H. Plum. 1975. Industrial Manufacture and Use of Organotin Compounds. Schering AG. Bergkamen, W. Germany.
Method: other: OECD Guide-line 471 and 472
Hansch C, Leo A (1979) Substituent Constants for Correlation|Analysis in Chemistry and Biology. John Wiley & Sons, New|York-Chichester-Brisbane-Toronto, pp 171, 218
Method: other: Acute Toxicity Test based on a procedure of the Committee on Methods for Toxicity Tests with Aquatic Organisms
Gelest, Inc. 1994. Material Safety Data Sheet. Dioctyldichlorotin 95% - SND4410. Issued 25.02.1994. Online catalog. http://www.gelest.com/gelest/gelest1/msds.asp?SND4410 (accessed December 2, 1999).
Bengtsson, B.-E. and Tarkpea, M., Marine Pollution Bulletin|14 (6), 213-214 (1983)
Method: other: GESAMP Reports and Studies No. 17 (IMO, London) 1982
Short-term toxicity to aquatic invertebrates, IUC4#22/Ch.4.2
Hoechst AG (1995): EG-Sicherheitsdatenblatt|Beta-Oxynaphthoesäure TRTR (09.01.1995)
Allyl Alcohol Consortium (2004c) Skin Sensitization Study of|Allyl Alcohol in Guinea Pigs (Maximization Test). Mitsubishi|Chemical Safety Institute Ltd. Study No B041136, unpublished|data
Patrick, R., Cairns, J., Jr. and Scheier, A. (1968) The|relative sensitivity of diatoms snails and fish to twenty|common constituents of industrial wastes. Prog. Fish-Cult.,|30(3), 137-140.
Method: other: Cairns, Scheier, Hess (1964)
Drottar, K.R. Butyl Acrylate: A 96-Hour Flow-Through Acute|Toxicity Test with the Sheepshead Minnow (Cyprinodon|variegatus). Testing Facility: WildLife International|Ltd., 8598 Commerce Drive, Easton, MD. Project Report No.|408A-110. Study Date: March 20, 1996.
BASF AG, 2003, Product Safety, data assessment, unpublished|calculation, SRC PCKOCWIN v1.66, 4 Dec. 2003
Usden, Psychotropic Drugs and Related Compounds 2nd ed., 1972.
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene|and Occupational Diseases, 32 (88), 52-53, 1988 cited in|RTECS, 2000/01
Hooftman, R.N. and J.M. de Wolf. 2003. Trichloromethylstannane (CAS# 993-16-8): Static acute toxicity test with the crustaean species Daphnia magna. TNO Report No. V2492/02. May 2003.
Degussa AG, unpublished report, 1988, Bühler test . Degussa report No. 88-0082-DKT
BASF AG: Toxicol. Laboratory - Unpublished Data: ZST-No.|90R0104/8638, Gen. 1989.
Matsushima T, Maramatsu M, Haresaku M (1985) Mutation tests|on Salmonella typhimurium by the preincubation methode. Prog|Mut Res 5: 181-186
Method: other: according Matsushima et al. (1980) in: Short term test systems for detecting carc.Norporth K, Springer, New York: preincubation method (30°C, 30 min)
WIL Research Laboratories (2005) A drinking water two-generation reproductive toxicity study of resorcinol in rats. Study Number 455003.
Method: other: EPA OPPTS 870.3800 and OECD Guideline 416
Zhanpeng, Hong, Shaoqi and Lixin (2000): Tox. and Environ.|Chem. Vol. 74, 245-255
Method: other: measurement of ATP content
Short-term toxicity to fish, IUC4#63/Ch.4.1
Method: other: similar to OECD Guide-line 403
BASF AG, Physikalische Chemie, unveröffentlichte|Untersuchung, Bericht BRU 92.201, 07.01.1992
Method: other (measured): Directive 79/831/EWG, appendix V, part A4, Feb. 1990
Method: other: Method following the protocol described by Schultz (1996)
CIBA-GEIGY Ltd. 1981. Report on Eye Irritation in the Rabbit After Single Application of TK 11638 (Irgastab T22M). Project No.: 811186. Basle, Switzerland. December 28, 1981.
Bomhard E and Löser E. Blankophor MBBH (Natrium-Salz):|Chronische toxikologische Untersuchungen an Ratten|(Fütterungsversuch über 2 Jahre). Report Nr. 7234, January|19, 1978. Institute of Toxicology, Bayer AG, Wuppertal,|Germany.
Method: other: internal method Bayer, combined chronic toxicity/carcinogenicity
BASF AG, unpublished calculation, EPISUITE, BCFWIN V 2.14, 2002
Method: other: calculation with BCFWIN V 2.14
Sayk F, Schmidt C (1986) Algen-Fluoreszenz-Autometer, eine|computergesteuerte Biotest-Meßapparatur. Z Wasser-|Abwasser-Forsch 19: 182 - 184
BASF AG, Department of Toxicology, unpublished data,|Report-Project No.: 26M0558/004110, 20/02/2001
Meylan WM et al (1993), Chemosphere 26: 2293-9.
BASF AG (2006). Product Details FORMIC ACID 99-100 %, 04 Oct|2006.
Stenbaeck F, Shubik P (1974) Lack of toxicity and carcinogenicity of some commonly used cutaneous agents. Toxicology and Applied Pharmacology 30:7-13.
BASF AG, Analytisches Labor; unveroeffentlichte|Untersuchung (J.Nr.106288/09)
Smyth Jr., H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C.|(1954). Range-finding toxicity data, List V. AMA Arch. Ind.|Hyg. Occup. Med. 10, 61-68.
Method: other: see Method and Test Condition
Clariant GmbH (1999): Unveröffentlichte Untersuchung|(99.0074)
Method: other: according to Ames et al. 1975; Mut.Res. 31, 347
Kuehn, R. und Pattard, M., Water Research 24 (1), 31-38|(1990)
Repeated dose toxicity: dermal, IUC4#13/Ch.5.4
Schering AG, Experimentelle Toxikologie. 1998. Acute toxicity of dibutyltin bis(2-ethylhexylthioglycolate) (ZK 26386) to the Zebra fish Danio rerio. Research Report No. IC20. Berlin, Germany.
Method: other (calculated): expert judgemant
Oishi et al.; Toxicology Lett. 6, 81-85 (1980)
Yanders, A.F. and Seaton, R.K.: Am. Nature. 96 (890),|277-280 (1962);|cited in: RIFM database, location no. 28702
Liu DHW, Bailey HC, Pearson JG (1983) Toxicity of a complex|munitions wastewater to aquatic organisms. Aquatic|Toxicology Hazard Assessment, 6th symposium: 135-150
Yaws CL, Yang H-C, Hopper JR, and Hansen KC (1990). Organic|chemicals: Water Solubility Data. Chemical Engineering /|July 1990, 115.
Wagner, R. and Kayser, G. (1990). Wasser Abwasser, 131, 4,|165-177
BASF AG, Product Safety, beta-Ionon R - Prenatal|developmental toxicity study in Wistar rats, oral|administration (gavage), unpublished report, project no.|30R0449/02056, 02/449-1, 19 May 2004
Method: other: in accordance with OECD TG 453, see freetext Method
Elf Atochem S.A. 1998. Isooctyl thioglycolate: Acute toxicity to daphnia. Centre d'application de Levallois. Study no. 4177/95/B.
Laham et al., Arch. Environ. Health 40, 301-306 (1985)
Bayer AG (1991). Internal Study: Untersuchungen zum|oekologischen Verhalten von Phosphortrichlorid. Study No.|242 A/91.
BASF AG, Product Database Fine Chemicals, status, 18 March|2004
Nippon Soda Co., LTD. (1985), Reverse mutation test with|CHEMICHLON G. unpublished report
Skin irritation / corrosion, IUC4#17/Ch.5.2.1
Jager, R., Peter, H., Sterzel, W., and Bolt, H.M.: J. Cancer|Res. Clin. Oncol. 114(1): 64-70 (1988), as cited in Ristau.
Method: other: method of Sterzel et al. (1984)
BASF AG (1987). Department of Ecology, test No. 01.451/86,|23 Jan 1987, unpublish
Howard PH (1989) Handbook of Environmental Fate and Exposure|Data for Organic Chemicals (2. ed.). Large Production and|Priority Pollutants, Lewis Publ., Chelsea, MI, pp 305-318
Adsorption / desorption, IUC4#8/Ch.3.3.2
Marhold, Prehled Prumyslove Toxikologie; Organicke Latky,|Avicenum, 663 (1986), cited in RTECS
CIT (1993) Acute dermal irritation in rabbits -|Isooctylthioglycolate, Centre International de Toxicologie,|Report no. 10270 TAL, December 1993.
Slesinski, R.S., Homan, E.R. and Frank, F.R. (1981)|N-(2-Aminoethylpiperazine) in vitro mutagenesis studies:|3-test battery. Unpublished report of Union Carbide|Corporation.
Method: other: method of O'Neill Mutation Research 45:91-101
Guerra D, Romano P, Zambonelli C (1981) Mutagenic effects of|sulfur dioxide on Saccharomyces cerevisiae diploid strains.|Experientia 37: 691-693
Genetic toxicity in vitro, IUC4#197/Ch.5.5
Short CR, King C, Sistrunk P, and Kriklyn MK (1983) Subacute|Toxicity of Several Ring-Substituted Dialkyanilines in the|Rat. Fund Appl Toxicol 3: 285-292
Dow Corning Corporation (1984) Internal Report No.|1984-I0005-1226.
Method: other: The study was conducted in conformance with Draft OECD Protocol Nos. 419 and 420 and in general conformance with OECD Health Effects Test Guidelines Nos. 471 and 472 (both May 26, 1983).
Hoechst AG (1988) Nitro-o-dichlor-benzol asym. Prüfung auf|Hautreizung am Kaninchen (unpublished report no. 88.2102)
Method: other: OECD Guide-line 404, see also freetext TC
Furukawa A, Ohuchida A, Wierzba K (1989) In vivo|mutagenicity tests on polyploid inducers. Environ Mol|Mutagen 14 (Suppl. 15): 63-64
BASF AG, Department of Ecology: Prüfung der Atmungshemmung|von Belebtschlamm durch 3-Methylbuten-2-al-1 im|Kurzzeitatmungstest, unpublished study, 01.0569/87, 08 Dec.|1987
Lewis, R.J. (1992) Sax's Dangerous Properties of Industrial|Materials, 8th Ed. 1, Van Nostrand, New York
Merck (1989) Oekotoxikologische Untersuchungen Bestimmung|der Fischgiftigkeit nach DIN 38412 Teil 15 report number|24/2/89
Posternak JM, Linder A and Vodoz CA (1969). Summaries of|Toxicological Data. Food Cosmet. Toxicol. 7, 405-407.
Weast, RC, Lide DR (1989) CRC Handbook of Chemistry and|Physics 70th ed. CRC Press Inc., Boca Raton, Florida, C -|112
Mochida, K. and Sugai, T. (1991) A Probable Case of Systemic|Contact Dermatitis from Parabens, Skin Res. 33, 198-203,|suppl. 11
CRC Handbook of Chemistry and Physics. 76th ed. Boca Raton, FL (1995-1996)., p. 3-291. cited by HSDB 21 Sep 2006
Dow Corning Corporation Internal Report Number|1981-I0005-900.
Inui, H. et al., Chemosphere 6, 383-391 (1979)
Rekker R.F., The Hydrophobic Fragmental Constant, Elsevier|Scientific Publishing Company, Amsterdam, 1977
Hartke, K. In: Hartke, K. & Mutschler, E., ed., Deutsches|Arzneibuch, 9. Ausgabe, Bd. 3, Wissenschaftliche|Verlagsgesellschaft, Stuttgart, 2426-2428 (1986)
Dow Corning Corporation (2009) Combined Repeated Dose|Toxicity Study with the Reproductive/Developmental Toxicity|Screening Test for Hexamethyldisilazane in Sprague-Dawley|Rats via Inhalation Exposure (Draft Report). Study Number|10124-102
Chicu, S. A. et al. (2000), An approach to calculate the|toxicity of simple organic molecules on the basis of QSAR|analysis in Hydractinia echinata (Hydrozoa, Cnidaria),|Quant. Struct. - Act. Relat. 19, 227-236
Life Sciences Research Office, Federation of American|Societies of Experimental Biology, Bethesda, Maryland (USA)|(1973): NTIS/PB 259 917
DuPont Haskell Laboratory for Toxicology and Industrial|Medicine (2001). H-24509 and H-24442: Two-week inhalation|toxicity study in male rats. Test report DuPont-4291, 170|pp. (unpublished).
Salmonella typhimurium TA98, TA1535, TA100, TA1537
Wass, U. et al.; Scand. J. Work Environ. Health, vol. 16,|208 - 214 (1990).
Johnson KA, Baker PC, Marty MS, Kan HL and Maurissen JP. 2002. Diethylene glycol mono-butyl ether: 13-week drinking water study in Fischer 344 rats. The Dow Chemical Company, Dept. of Toxicology and Environmental Research and Consulting, Study ID 001204, dated May 9, 2002.
Method: other: OECD Guideline 408. EEC Part B.26, Japanese MITI, USEPA-OPPTS 870.3100
Loeb, H.A. und Kelly, W.H., Special Scientific|Report-Fisheries No. 471, Washington, D.C. (1963)
Moelwyn-Hughes, E.A. The hydrolysis of the methyl halides.|Proc. Roy. Soc. Lond. A 164:295-306 (1938), as cited in|Zafiriou.
Bringmann, G. und Kuehn, R., Z. Wasser Abwasser Forsch. 15|(1), 1-6 (1982)
Meylan W. and Howard P. 1999. EPIWin Modeling Program.|Syracuse Research Corporation. Environmental Science|Center, 6225 Running Ridge Road, North Syracuse, NY|13212-2510
Walsh,K.J., A hydrolysis study of 14-C butyl acrylate,|unpublished study report of Ricerca Inc., Dept. of Environmental Sciences, Project Ident. 88-02707, 1990
De Flora S., Zanacchi P., Camoirano A., Bennicelli C.,|Badolati GS. (1984), Genotoxic activity and potency of 135|compounds in the Ames reversion test and in bacterial|DNA-repair test: Mutat. Res. 133, 161-198
Andersen, K.E. et al.: Acta Derm. Venerol. (Stockholm) 65,|472-478 (1985), No information
Ding, R. Tscunekawa, N. And K. Obata. (2004) Cleft palate|by picrotoxin or 3-MP and palatal shelf elevation in|GABA-deficient mice. Neuroltoxicol. Teratol. |26(4):587-592. July-August.
Salmonella typhimurium TA1535, TA1537, TA1538, TA98 and TA100
BASF AG, Product Safety, Summary of results, Beta-Ionon R, |Maternal toxicity study in Wistar rats (range finding), oral|administration (gavage), unpublished report, project no.|10R0449/02050, 02/449-1, 12 May 2004
Adsorption / desorption, IUC4#6/Ch.3.3.1
NTP, 1992. Toxicology and Carcinogenesis Studies of Methyl|Bromide (CAS No. 74-83-9) in B6C3F1 Mice (Inhalation|Studies). National Toxicology Program, Research Triangle|Park, N.C. March 1992. NTIS Publication Number: PB92189257.
Bayer AG (2003) 6PPD|(N-(1,3-Dimethylbutyl)-N´-phenyl-1,4-phenylenediamine)|CAS-No. 793-24-8. Calculation of |- log Octanol-Water Partition Coefficient with KOWWIN|v.1.66, 2000|- Henry´s Law Constant with HENRYWIN v.3.10, 2000|- Indirect Photodegradation with AOPWIN v.1.90, 2000|- Soil Adsorption Coefficient with PCKOCWIN v.1.66, 2000|- Mackay-Distribution Level I according to Mackay, D., 1991
Method: other (calculated): AOP Program (vl. 90)
Degussa AG, unpublished, report no.: Degussa AG, US-IT-Nr.|88-0013-DGO (1988).
Short-term toxicity to aquatic invertebrates, IUC4#44/Ch.4.2
BASF AG (1985). Department of Ecology, report test No.|01.1277, Lab No. 18365, 17 Oct 1985, unpublished.
BASF AG (1985). Department of Analytical Chemistry, report|BRU 85.185, 04 Nov 1985 (unpublished).
Juhnke, I. und Luedemann, D., Z. Wasser-Abwasser-Forschung|11 (5), 161-164 (1978)
Anon Das (1985a). Nucleus (Calcutta) 28, 198 {cited in RTECS, 1998).
Ministry of Environment, Japan (1999d): unpublished report on chronic toxicity to daphnids
National Academy of Science, National Research Council,|Chemical-Biological Coordination Center, Review, 5,17 (1953)
Dresp, J. and Bauchinger, M.: Mutat. Res. 182, 277 (1987);|abstract no. 6, No information
Sturm: Dissertation Wuerzburg 1908: cited in Flury, F.|and Zernik, F.: Schaedliche Gase, Berlin (1931)
Genetic toxicity in vitro, IUC4#193/Ch.5.5
Carpenter CP and Smyth HF (1946). Chemical burns of the|rabbit cornea. Am. J. Ophthalmol. 29, 1363-1372.
Schwarz,Th. et al., WLB Wasser, Boden, Luft, 26-27, 1996, No information
Wlodkowski, T., Rosenkranz, H., (1975): Mutagenicity of|sodium hypochlorite for Salmonella typhimurium. Mutation|Research, 31, 39-42.
Method: other: Standard Ames test (no details provided)
Brekelmans M, 2001, Determination of the hydrolysis of linalyl acetate as a function of pH F., Hoffmann-La Roche Ltd.
Method: other: calculated according to TGD (May 2003)
Prehled Prumyslove Toxicologie; Organicke Latky. Marhold J.,|Prague Czechoslovakia, Avicenum. page 207, 1986.
Von der Hude W, Behm C, Gürtler R, Basler A (1988)|Evaluation of the SOS chromotest. Mutat Res 203: 81-94
Covance Laboratories (1998). LHS-Super acute oral toxicity|study in the rat. Unpublished final study report No.|1516/2-1032 dated March 1998. Sponsored by Hydro Nutrition,|Oslo.
Pham, M-Q.K., Harvey, S.P., Weigand, W.A., Bentley, W.E.:|Reactor comparisons for the biodegradation of thiodiglycol,|a product of mustard gas hydrolysis. Appl. Biochem.|Biotechnol. 57/58, 779-789 (1996)
Menzie, G.K. (1958). Dow Corning Technical Report|1958-I0030-1625. Dow Corning Corporation, Midland, MI, USA.
Dave, G. und Lidmann, U., Hydrometallurgy 3, 201-216 (1978)
Smith S. Three-generation reproduction study with FA-15 in|albino rats. Final Report IBT No. B517(B), October 29, 1973.|Industrial Bio-Test Laboratories Inc., Northbrook, Il, USA.
National Technical Information Service, AD-A125-539; cited|in RTECS database, No information
LeBlanc GA (1980). Acute toxicity of priority pollutants to|water flea (Daphnia magna). Bull. Environ. Contam. Toxicol.|24, 684-691.
Method: other: Methods for acute toxicity tests with fish, macroinvertebrates, and amphibians, US EPA (1975)
BASF AG, Product Safety Department, unpublished study,project no. 12F0674/025053 (to be finalized).
National Toxicology Program. 1984. Final report: Diethylene glycol monoethyl ether: Reproduction and fertility assessment in CD-1 mice when administered in the drinking water. NTIS PB85137123, dated Nov. 8, 1984.
triisooctyl 2,2',2''-[(butylstannylidyne)tris(thio)]triacetate (IUC4 DSN 28)
Hubbs, A.F., Harrington, D.D., 1986. Further evaluation of|the potential gastric carcinogenic effects of subchronic|methyl bromide administration. In: Proceedings of the 36th|Meeting of the American College of Veterinary Pathology and|the Annual Meeting of the American Society for Veterinary|and Clinical Pathology, Denver, Colorado, December 1985. |Denver, Colorado, American Society for Veterinary and|Clinical Pathology, p. 92.
Mersch-Sundermann V, Schneider U, Klopman G, and Rosenkranz|HS (1994). SOS induction in Escherichia coli and Salmonella|mutagenicity: a comparison using 330 chemicals. Mutagenesis|9, 205-224.
Lyman WJ (1990) Adsorption Coefficient for Soils and|Sediments. In: Lyman WJ, Reehl WF, Rosenblatt DH (eds)|Handbook of Chemical Property Estimation Methods. American|Chemical Society, Washington, DC
Method: other: (calculation) Kenaga & Goring 1978
Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA1538, TA1978
Morita T, Takeda K, and Okumura K (1990). Evaluation of|clastogenicity of formic acid, acetic acid and lactic acid|on cultured mammalian cells. Mut Res 240, 195-202.
Marhold J (1986) Prehled Prumyslove Toxikologie; Organicke|Latky 558, Prague
Activity of C-8013-132-6 in the Salmonella Microsomal Assay|for Bacterial Mutagenicity, Microbiological Associates,|Bethesda MD/USA, Project No T1150 (1977).
Yi, H. et al. (2005): Effect of sulfur dioxide hydrates on|cell cycle, sister chromatid exchange, and micronuclei in|barley. Ecotoxicol. Environ. Saf. 62(3), 421-426
Mastalski K and Hartke K. Two-year chronic oral toxicity|study with FA-15 in Beagle dogs. Report IBT No. 651-09964-B,|December 4, 1973. Industrial Bio-Test Laboratories Inc.,|Northbrook, IL, USA.
Schultz TW (1987) The use of the ionization constant pKa) in selecting models of toxicity in phenols. Ecotoxicology and Environmental Safety. 14:178-183.
Method: other: according to a dutch national standard method: NEN 6504, 1980 (Wateronderzoek. Bepaling van de acute toxiciteid met Poecilia reticulata)
Hüls AG (1993d). Bestimmung der biologischen Abbaubarkeit|von Vestamin IPD im DOC-DIE away test. Report No. DDA-02|(unpublished).
Jeffers PM, Wolfe NL (1997). Hydrolysis of methyl bromide, ethyl bromide, chloropicrin, 1,4-dichloro-2-butene, and other halogenated hydrocarbons. ACS Symposium Series 652, 32-41.
Genetic toxicity in vitro, IUC4#259/Ch.5.5
Bringmann,G., Kuehn,R., Zeitschrift fuer Wasser- und |Abwasser-Forschung 1, 26-31, (1980)
Reported by Kennedy G.L. (1986). CRC Crit. Rew. Toxicol.,|17:129-182 from Roberts B.L. and H.W. Dorough (1984).|Environ. Toxicol. Chem. 3(1):67-78.
BASF AG (1971). Department of Toxicology, acute dermal toxicity rabbit, unpublished study, Study No. XXI/183, 22 December 1971.
Vos, J.G., A. de Klerk, E.I. Krajnc, W. Kruizinga, B. van Ommen, and J. Rozing. 1984. Toxicity of bis(tri-n-butyltin)oxide in the rat: II. Supression of thymus-dependent immune responses and of parameters of nonspecific resistance after short-term exposure. Toxicol. Appl. Pharmacol. 75:387.
Esso Research and Engineering Company, Linden, N.J. /|Hazelton Labs Inc. (1965b). LC50 Determination - acute|inhalation exposure MRD-64-20, MRD-64-21, MRD-64-24.|NTIS/OTS Microfiche 0206267, Doc 878210933.
Method: other: Acute Inhalation Toxicity: Whole body exposure
Repeated dose toxicity: oral, IUC4#48/Ch.5.4
FMC Corp. data, TSCA 8d submission 86860000107 (1981)|cited in Chem. Reg. Reporter 11-13-87, 1244-1322 (1987)
Short-term toxicity to fish, IUC4#62/Ch.4.1
Bioaccumulation: aquatic / sediment, IUC4#9/Ch.3.7
Radionova RP, Ivanov NG (1979). Comparison of the level of|irritant properties of industrial toxins on the skin and|respiratory system Toksikol Nov Prom Khim Veshchestv VOL 15,|58-63, 145-50.
Chang, L.W. et al.: Environ. Mutagen. 5, 381 (1983);|abstract Bb-13, No information
Genetic toxicity in vivo, IUC4#58/Ch.5.6
RIFM, 2000, Research Institute on Fragrance Materials Inc.,|Ionone Beta: Determination of ready biodegradability|(CO2-Evolution test), unpublished study, No. BL6803/B,|finalised at 3rd May 2000
Method: other: according to ISO 14593 (CO2-Evolution Test)
metabolically-competent human MCL-5 cells
Ellis HV, Hong CB, Lee CC (1980). Mammalian toxicity of|munition Compounds. Progress Report No. 11, Midwest Research|Institute Project No. 3900-B.
Daniel, F. B., Condie, L. W., Robinson, M., et al. (1990).|Comparative subchronic toxicity studies of three|disinfectants. J. Am. Water Works Assoc. 82, 61-69
Hoechst AG (1989): Produktinformation beta-Naphthol der|Abt.Verkauf Feinchemikalien (Maerz 1989)
Takenaka, T. et al.: Parf. Cosm. Sav. 13, 699-706 (1970)
Dupont Chem (1992) Initial submission: acute toxicity of|benzene, 1-chloro-2-chloromethyl in fathead minnows with|cover letter dated 081092, Haskell Laboratory for Toxicology|and Industrial Medicine (1979) EPA Doc. ID 88-920009285,|NTIS/OTS 0571039.
Bringmann G, Kühn R (1982) Ergebnisse der Schadwirkung|wassergefährdender Stoffe gegen Daphnia magna in einem|weiterentwickelten standardisierten Testverfahren. Z Wasser|Abwasser Forsch 15 (1): 1 - 6
Method: other: Immobilization test according to Bringmann G, Kuehn R (1977) Z Wasser Abwasser Forsch 10, 162 - 166
Microtest Research LTD (1988): Study to determine the ability of Benzoguanamine to induce mutation in five histidine-requiring strains of Salmonella typhimurium, Study No. STG 1/S
Klimmer, O.R. von. 1969. Arzneimittel-Forsch. 19:934. IN Toxicological Data on Organotin Compounds. Smith, P.J. International Tin Research Institute. Publication 538.
Givaudan, 1991, Group Safety & Environmental Protection,|IONONE BETA SYNTHETIC "Activated Sludge, Respiration|Inhibition Test", unpublished study, 19 Feb. 1991
Sellakumar A.R. et al.: 1985, (prelimary information also in|Albert et al, 1982), No information
Bedford, P. and Fox, B.W.: Chem.-Biol. Interact. 38,|119-126(1981), No information
Genetic toxicity in vitro, IUC4#224/Ch.5.5
BASF AG, Report on the study of the acute oral|toxicity,83/44, rat/oral, 1983
Method: other: OECD Guide-line 422 'Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening test'
Hoechst AG (1988): Unpublished study. BONS - Prüfung auf|sensibilisierende Eigenschaften an|Pirbright-White-Meerschweinchen im Maximierungstest (in|German) (Ber.-Nr. 88.1733), 26 Oct 1988
Irish, D.D., Adams, E.M., Spencer, H.C., Rowe, V.K., 1940.|The response attending exposure of laboratory animals to|vapors of methyl bromide. J. Ind. Hyg. Toxicol., 22:218-230.
Grant: Tox of the Eye, pg. 613 (1986), as cited in HSDB.
NTP (1991) 4-Chloronitrobenzene Reproduction and Fertility|Assessment in Swiss CD-1|mice when administered via gavage. Final Report, July, 1991
Method: other: Continuous breeding protocol, task 1: dose finding study, 8 mice/sex/group, clin. signs of tox., bw., water consumption
EA Japan (Environmental Agency, Japan) (1999d). Chronic|aquatic toxicity of dicyclohexylamine on Daphnia magna. MOE|(Ministry of the Environment, Japan) unpublished data.
Method: other: OECD Guideline 202, part 2 "Daphnia sp., Reproduction Test" and the Draft Test Guideline 211 (April, 1997, OECD)
Salmonella typhimurium TA 100, TA 1535, TA1537, TA 1538 TA 98 and Escherichia coli WP2uvrA
Salmonella typhimurium TA 98, TA 100, TA 1537
Murphy JC, Osterberg RE, Seabaugh VM, bierbower GW (1982).|Ocular irritancy responses to various pHs of acids and bases|with and without irrigation. Toxicology, 23, 281-291.
Method: other: according to Uno Y. et al., Toxicol.Lett.63,191-199,201-209 (1992),
Covance Laboratories (1998). Formi LHS. Induction of|chromosome aberrations in cultured human peripheral blood|lymphocytes. Unpublished study report No. 1516/8-1052 dated|April 1998. Sponsored by Hydro Nutrition, Oslo.
Gottschalk, C. et al., Beitrag zur Beurteilung von 19|gefaehrlichen Stoffen in oberirdischen Gewaessern,|Umweltbundesamt (1986) quoted from Althaus, H., et al.,|Dokumentation der Literatur ueber Wirkungskonzentration|(gesundheits-) schaedigender bzw. toxischer Stoffe in Wasser|fuer niedere Wasserorganismen sowie kalt- und warmbluetige|Wirbeltiere einschliesslich des Menschen bei oraler Aufnahme|des Wassers oder Kontakt mit dem Wasser. - Erstattet im|Auftrag des Ministeriums fuer Ernaehrung, Landwirtschaft und|Forsten des Landes Nordrhein-Westfalen, Duesseldorf.|Hygiene-Institut des Ruhrgebietes, Gelsenkirchen (1971)
Grant, W.M. (1986) Toxicology of the eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher,. 322
Mehta, R.D. & von Borstel, R.C., Prog. Mutat. Res. 5,|271-284 (1985)
Method: other: according Preston et al., 1987
Method: other: ex vivo (in vitro/in vivo) DNA damage - eukaryotes (mammalian cells/UDS)
Genetic toxicity in vivo, IUC4#73/Ch.5.6
Method: other: bacterial growth inibition test according to Alsop et al. (1980) J. WPCF 52:2452
Leo, A. et al., Partition Coefficients and their uses,|Chemical Reviews, 71, 525-616 (1971)
Fujita, H., Sasaki, M., (1987): Mutagenicity test of food|additives with Salmonella typhimurium TA 97, TA 102(II).|Ann. Rep. Tokyo Metr. Res. Lab. P.H., 38, 423-430.
Method: other: comparable to OECD guideline 473
Blum DJW, Heergenroeder R, Parkin GF, Speece RE (1986) Anaerobic treatment of coal conversion wastewater constituents: biodegradability and toxicity. Journal of the Water Pollution Control Federation 58:122-131.
Method: other: Serum Bottle Test, determination of gas production (CO2 and methane)
Method: other: 42 rats (no details given)
Anderson, R., B. Arkles, and G.L. Larson (1987) Silicon|Compounds - Register and Review Catalog. Petrarch Systems,|Silanes and Silicones Group, Bristol, PA.
Anderson, Styles (1978) Br. J. Cancer 37:924-930.
IRDC (1976) Acute Dermal Toxicity (LD50) in Rabbits.|International Research and Development Corporation (IRDC).|Study #: 378-001. Study Date: July 15, 1976.
Hooftman, R.N. and J.M. de Wolf. 2003. Butyltrichlorstannane (CAS# 1118-46-3): Semi-static acute toxicity test with the zebra fish Branchydanio rerio. TNO Report No. V2494/03. August 2003.
Bayer AG (1986). Water solubilities of several chemicals.|Unpublished report.
Ministry of International Trade and Industry (MITI) (1992): |Chemicals Inspection and Testing Institute (CITI) (ed.);|Japan Chemical Industry Ecology - Toxicology and Information|Center 1-27, 3-37
Method: other: Japanese Industrial Standard (JIS K 0102-1986-71)
IIT Research Institute. 1990. Acute Oral Toxicity Study of|Isophthalic Acid in Rats. Study No. 1553.
Method: other (measured): dynamic (argon atmosphere); test procedure according to an internal BASF standard, comparable to OECD 104
Ward, T.J., P.L. Kowalski, and R.L. Boeri. 1995. Acute toxicity of the water accommodated fraction (WAF) of alkyltin MA to the daphnid, Daphnia magna. T.R. Wilbury Laboratories, Inc. T.R. Wilbury Study Number 862-MO.
Shimizu H et al. 1985. Jpn J Ind Health 27: 400-419 as cited in IUCLID.
Method: other: according to B Ames et al. (1975) Mutat Res 31:347-364
Botham, P. A. et al.: The Skin Corrosivity Test in vitro.|Results of an Inter-laboratory Trial., Toxic, in Vitro, 6,|191-194(1992)
Allied Corproation: Dept. of Toxicology, Report No.|MA-179-81-1 03.10.1983
IBT (1974). Acute Dust Inhalation Toxicity Study with|Irganox 1300 Paste in Albino Rats. Industrial Bio-Test|Laboratories, Inc. Unpublished report # 663-05810. December|18, 1974.
Method: other: Not indicated (used as range finding test)
Scheunert D, Vockel W, Klein W, Korte F (1981) Fate of|14C-Allylalcohol Herbicide in Soils and Crop Residues.|Journal of Environmental Science and Health. Part. B,|Pesticides, Food Contaminants, and Agricultural Wastes 16,|719-742
Dupont de Nemours (1981) Inhalation median lethal|concentration of benzene, 1-chloro- 4-nitro- in rats. 19.|Nov. 1981: EPA-OTS0571644 and EPA-OTS0557112
Method: other: head-only exp., atmosph. contained vapor and micro- crystaline particles (particle size: 2.7 up to greater 90 u, respirable fraction: 6.8 to 92.3 %), 16100 mg/m³ was the highest practical concentration that could be generated
Ferard, J.F. et al., Sciences de l'eau 2 (2), 221-237 (1983)
Syracuse Research Corporation. 2000. Data from SRC PhysProp Database. http://esc.syrres.com/interkow/webprop.exe?CAS=683-18-1 (accessed December 11, 2000).
Horn WM van, Anderson JB, Katz M (1949). The effect of|kraft pulp mill wastes on some aquatic organisms. Am. Fish.|Soc., 79, 55-63.
Ishidate M, Harnois MC, Sofuni T (1988) A comparative|analysis of data on the clastogenicity of 951 chemical|substances tested in mammalian cell cultures. Mutation Res|195: 151-213
Ciba (1982b). Eye Irritation in the Rabbit After Single|Application of TK 10027. Unpublished report # 811497. March|17, 1982.
Method: other: exposure to 62 ppm = 0.32 mg/l for 4 h; inhalation of saturated vapor
Ministry of International Trade and Industry (MITI) (1992):|Biodegradation and bioaccumulation data of existing|chemicals based on the Chemical Substances Control Law|(CSCL), Japan. Chemicals Inspection and Testing Institute|(CITI) (ed.); Japan. Chemical Industry Ecology - Toxicology|and Information Center 14-27, 4-29
Method: other: according to OECD Guide-line 305 C "Bioaccumulation: Degree of Bioconcentration in Fish"
Wurst, M. and Churacek, J. (1971) Analyse von|Organosilicium-Verbindungen VI. Retentions Indicies der|Organosilicium Verbindungen bei der Gas Chromatographie.|Collect. Czech. Chem. Commun., 36, (1971) 3497.
Evaluation of the Health Aspects of Niacin and Niacinamide as food ingredients (1979). Prepared for FDS
Monsanto Co. (1986) A range finding study of nitrated|orthene administered by gavage to pregnant rats. Monsanto|Co., St. Louis (OTS0524331, 88-900000145)
Ladd R. Teratogenic study with FA-15 in albino rabbits.|Report IBT No. J523, May 23, 1972. Industrial Bio-Test|Laboratories Inc., Northbrook, IL, USA.
ACUTE TOXICITY TO BLUEGILL, RAINBOW TROUT AND THE WATER|FLEA. E G&G, BIONOMICS AQUATIC TOXICOLOGY LABORATORY,|WAREHAM, MA, JULY, 1977.
Smyth HF, Seaton J, Leslie L. 1939. Mellon Institute Industrial Research Program, University of Pittsburgh report to Carbide and Carbon Chemicals Corp., dated March 31.
BASF AG, Abteilung Toxikologie; unveroeffentlichte|Untersuchung (88/600), 16.03.1989
Method: other: DIN 38412, Determination of the effects of substances in water on fish
Haderlein SB, Weissmahr KW, Schwarzenbach RP (1996).|Specific adsorption of nitroaromatic explosives and|pesticides to clay minerals. Environ. Sci. Technol. 30,|612-622.
Potokar M, Grundler OJ, Heusener A, Jung R, Mürmann P,|Schöbel C, Suberg H and Zechel HJ (1985). Studies on the|design of animal tests for the corrosiveness of industrial|chemicals. Food Chem. Toxicol. 23, 615-617.
Punte, C.L. et al. (1962). Amer. Ind. Hyg. Assoc. J., 23, p. 194-198, cited from Waritz and Brown (1975).
Benschotten, J.E.V., Jensen, J.N., Brady, T.J., Lewis, D.P.,|Sferrazza, J., Neuhaeur, E.F. (1993); Response of zebra|mussel veligers to chemical oxidants; Wat. Res., 27(4),|575-582.
Short-term toxicity to aquatic invertebrates, IUC4#43/Ch.4.2
Springborn Laboratories, Inc.: Life Sciences Division,|SLS Study No. 3224.7, 25.04.1991 and 3224.3
The Merck Index (2001) S. Budavari (ed.), 13th ed., Merck &|Co., Inc., Whitehouse Station, NJ.
BASF AG, Department of Ecology, 3-Methylbuten-2-al-1,|Algenzellvermehrungshemmtest, unpublished study, 1/87/1059,|10 Jan. 1991
Method: other: Scenedesmus cell multiplication Inhibition Assay according to DIN 38412 Part 9 (Bestimmung der Hemmwirkung von Wasserinhaltsstoffen auf Gruenalgen)
DuPont (1978). Chronic inhalation toxicity study on rats exposed to 1,4-dichlorobutene-2: 90-day Interim Report. Haskell Laboratory, Report No. 977-77 from January 27, 1978 (NTIS OTS 543796).
Method: other (calculated): KOWWIN Program (v1.66)
Method: other: Kada, T. et al.: in: Kilbey, B.J. et al. (eds.): Handbook of Mutagenicity Test Procedures, 2nd ed., Amsterdam, Elsevier, 13-31, (1984)
Ishiguro Y, LaLonde R, Dence C, Santodonato J (1987)|Mutagenicity of chlorine substituted furanones and their|inactivation by reaction with nucleophiles.|Environ.Toxicol.Chem. 6: 935-946
Method: other: Ames BN et al. (1975) Mutat Res 31: 347-363, Maron DM, Ames BN (1983) Mutat Res 113: 173-215
SRC (2007) Syracuse Research Corporation, PhysProp Database
Bringmann, G. und Kuehn, R., Z. Wasser-Abwasser-Forschung|15(1), 1-6 (1982)
Method: other: (calculated) WSKOW v1.36 Program
McKee & Wolf (1963). Water quality criteria. California|State Water Resources Control Board. Publication 3-A.
Method: other: Macdonald et al. (see remark)
Monsanto Co. (1984) Four week study of nitrated orthene|administered in the diet to Sprague-Dawley rats (report no.|ML-83-275). Monsanto Co., St. Louis (OTS0534360,|86-920000155)
ABCR GmbH & Co. 2000. Data Sheet. Dioctyldichlorotin 95%. Online catalog. http://www.abcr.de.cgi-bin/db2www.exe/abcrcate1.ma...:24.2000artnr=&artbez =&casnr=3542-36-7 (accessed March 7, 2000).
TNO (1968). Range Finding (28-Day) Toxicity Test with TA|1201 and TA 1202 in Albino Rats. Central Institute for|Nutrition and Food Research, Zeist. Unpublished report # R|2764. October 1968.
Bayer AG (1972). Steinhoff D. Akute Toxizitaet. Short report|dated 1972-09-28.
Cronin M.T.D., Zhao Y.H., Yu R.L. (2000) Envir. Toxicol.|15(2), 140-148
CERI (1999). Report No. 91533. Chronic toxicity test on|inhibition of reproduction to Daphnia magna. Chemicals|Evaluation and Research Institute of Japan.
TSCATS: OTS 0510381, Doc. I.D.: 878216453, 11.17.1953,|Union Carbide Corp. as cited in IUCLID.
Acute toxicity: inhalation, IUC4#90/Ch.5.1.2
Haesen, S. et al. (1988): Carcinogenesis 9, 1755 - 1761
Schering AG. 1989. Determination of the Water Solubility of Di-n-Butyltin Oxide. Report No. VE 01/89. 18.01.1989.
BASF AG, Product Safety, 3-Methyl-2-buten-1-al (Prenal) -|(second) prenatal developmental toxicity study in Wistar|rats oral administration (gavage), unpublished report,|project no. 30R0680/00125, 16 Aug. 2002
Kobayashi K, Oshima Y, Hamada S, Taguchi C (1987) Induction of Phenol-Sulfate Conjugating Activity by Exposure to Phenols and Duration of Its Induced Activity in Short-Necked Clam. Nippon Suisan Gakkaishi, 53(11): 2073-2076 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Short-term toxicity to aquatic invertebrates, IUC4#46/Ch.4.2
Industrial Biology Laboratories Inc, Shelanski MV (1963 c)|Modified Schwartz patch test. Study report Project No.|SH-63-14. Unpublished study of Monsanto Chemical Co
Lamb CB and Jenkins GF (1952) Purdue 8th Industrial Waste|Conference, Purdue University, 326-339
Koopman, T.S.M. and Pot, T.E. (1986) Acute oral toxicity|study with calcium chloride hexahydrate in male rabbits.|Duphar Report No. 56645/49/86.
BASF AG (2001). Department of Ecology, Determination of the|acute effect of chemicals on the mortality of the earthworm|Eisenia foetida (Michaelsen); unpublished data (00/0113), 10|January 2001
Method: other: OECD guideline 207 (1984)
Method: other: Embryo development inhibition assay
Method: other: comparable to OECD 204 (fish, prolonged toxicity test, 1984)
Hahne R. 2002a. Acute Toxicity of the Water Accommodated |Fraction (WAF) for 2-Ethylhexyl Acetate to the Rainbow Trout, |Oncorhynchus mykiss, Determined under Static Test Conditions. |Report #46955 prepared by ABC Laboratories Inc., Columbia |Missouri. May 22, 2002
Method: other: According to the method described in Russfield, A.U. et al. (1975) Toxicol. Appl. Pharmacol., 31, 47-54
Leegwater DC (1989). QSAR-analysis of acute toxicity of|industrial pollutants to the guppy using molecular|connectivity indices. Aquat. Toxicol. 15, 157-168.
Anderson, B.G. (1944) The toxicity thresholds of various|substances found in industrial wastes as determined by the|use of Daphnia magna. Sewage Works J., 16(6), 1156-1165.
Method: other: corresponding to OECD guideline 305 C (1981)
Anderson BG (1946). The toxicity thresholds of various|sodium salts determined by the use of Daphnia magna. Sewage|Works Journal, January 1946, 82-87.
Method: other: praeincubation assay, S9-mix from hamster and rat liver
Reddy KS and Menary RC: Effects of nitrogen source, rate and|application time on boronia (Boronia megastigma Nees) leaf|nitrogen and flower production. Fertilizer Research 19,|169-174 (1989)
Horn H.J. (1961). Toxicol. App. Pharmacol., 3:12-24.
Vial A (1991) FAT 65'023/L: Report on the acute toxicity|test of FAT 65'023/N to earthworm. CIBA-GEIGY Ltd. CH-4002|Basel (Switzerland)
Verschueren K. 1983. Handbook of environmental data on organic chemicals. 2nd Ed. Van Nostrand Reinhold, New York. As referenced in Staples CA, Boatman RJ, Cano ML. 1998.|Ethylene glycol ethers: an environmental risk assessment. Chemosphere 36(7):1585-1613.
BASF AG, Safety data sheet PRENOL, 28.03.2003 (30035067)
ALOGP Program (http://www.lhn.unil.ch/Appl/cchem2.html)
Rosen JD, Segall Y, Casida JE (1980) Mutagenic Potency of|Haloacroleins and Related Compounds, Mutation Research 78,|113-119
Salmonella typhimurium TA 92, TA 94, TA 98, TA 100, TA 1535, TA 1537
Ministry of Health and Welfare (1999) In vitro chromosomal|aberration test of 1-chloro-2 (chloromethyl)benzene on|cultured Chinese hamster cells. Japan Toxicity Testing|Reports of Environmental Chemicals, 7,509-512.
Epstein, S.S. et al. (1972): Toxicol. Appl. Pharmacol. 23,|288 - 325
Wierich, Glycerin (Henkel KGaA Reg. no. 1518), 1968 (rewrite|of September 1996) (110).
Horowitz, A. et al., Dev. Ind. Microbiol. 23, 435-444 (1982)
Method: other: Flow-through Bioaccumulation Test
IUCLID:Monroe, T.J. and Mitchel. M.A. : Cancer Res, 53,|5690-5696(1993).
Maronpot, R.R. et al.: Toxicology 41, 253-266 (1986), No information
Repeated dose toxicity: inhalation, IUC4#91/Ch.5.4
Ema, M. and A. Harazono. 2001. Toxic effects of butyltin trichloride during early pregnancy in rats. Toxicology Letters. 125:99-106.
Shimizu, Takemura (1984): Occup. Health Chem. Ind., Proc.|Int. Congr., 11th, Meeting date 1983, 497-506, ed. by R.R
Alexandrov, I.D. and Somin, Y.A.: Dros. Info. Serv. 58,|14-16 (1982), No information
BASF AG (1982). Department of Toxicology, study No. 82/23,|08 Mar 1982 (unpublished).
Method: other: German Industrial Standard DIN38412 Part 15 (draft January 1979)
Dow Corning Corporation (2007) Non-Regulated Study: |A Seven-Day Inhalation Range-Finding Toxicity Study |of Hexamethyldisilazane in Sprague-Dawley Rats. |Report Number: 2007-I0000-58375.
McGowan, E.M. (1966), Menthol Urticaria, Arch. Derm. 94,|62-63
FMC Corporation, A 13-week inhalation toxicity study (with|recovery) of ammonium persulfate in albino rats, Study no.|I97-2205, 1998.
Academy of Natural Sciences of Philadelphia (1971)
Particle size distribution (Granulometry).001
Kushneva V.S. et al.: Gig. Tr. Prof. Zabol., 1, 46-47, (1983); cited in WHO: Environmental Health Criteria 65, WHO, Geneva, pp. 93 ff., (1987) as cited in IUCLID.
Acros Organics (2005). Material safety data sheet, update 24|Mar 2005.
Method: other: evaporation of 10 g test material at room temperature in a 400 l-chamber; a concentration of 4.75 mg/l was calculated from the amount of test material evaporated within the 1 h exposure duration
BASF AG (1985) Department of Toxicology. Akute|Inhalationstoxizität LC50 4 Stunden (Ratte) Dampf-Versuch|von Neodecansäurechlorid (Substanz-Nr. 83/333). Unpublished|study report dated Apr 18, 1985.
BASF AG, Product Safety, data assessment, SRC BCFWIN v2.14,|25 Oct. 2002
Method: other: calculated, SRC - BCFWIN v2.14
Short-term toxicity to fish, IUC4#83/Ch.4.1
Oda, Y. et al.: Mutat. Res. 147, 219-229 (1985), No information
Genetic toxicity in vitro, IUC4#142/Ch.5.5
Melting point/freezing point, IUC4#23/Ch.2.1
Method: other: as described in "Standard Methods for the Examination of Water and Wastewater", 16th ed., USPHA, Washington, D.C., 1985."
Method: other: 2-stage carcinogenesis study
Schering AG. 1989. Detection of Gene Mutations in Mammalian Cells in vitro (HGPRT Test). Study conducted by CCR Cytotest Cell Research GmbH & Co. KG. CCR Project 142503. 20.03.1989.
BUA (2005): Benzenesulfonic acid,|2,2'-(1,2-ethenediyl)bis[5-[[4-(4-morpholinyl)-6-(phenylamin|o-1,3,5-triazin-2-yl]amino]-, disodium salt. Calculation of|Soil Adsorption coefficient with PCKOCWIN v1.66 (2004).
Method: other (calculation): with PCKOCWIN v1.66, 2004
Landry, T.D., Quast, J.F., Gushow, T.S. and Mattsson, J.L.:|Funda. and Appl. Toxicol. 5:87-98 (1985).
Ferrat R (1992) FAT 65'023/N: Hydrolysis as a function of|pH. CIBA-GEIGY Ltd., CH-4002 Basel (Switzerland)
National Institute of Environmental Research(NIER), Korea(2001), Test of Acetanilide Hydrolysis as a Function of pH(tested by LGCI)
Kreiger, R.A. and Garry, V.F.: Mutat. Res. 120, 51-55 (1983), No information
Genetic toxicity in vitro, IUC4#158/Ch.5.5
John-Green, J., Weisch, F., and Bus, J.S.: Teratology|32:483-487 (1985).
Method: other: Repeated insult patch test
SELYE, H. (1973) PRODUCTION OF PERFORATING DUODENAL ULCERS BY 3,4-TOLUENEDIAMINE IN THE RAT. PROC. SOC. EXP. BIOL. MED. 142(4), 1192-1194. (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com)
Dow Corning Corporation (2002) Material Safety Data Sheet|Dow Corning (R) 3-7110 Ethyltriacetoxysilane.
Huels AG (1993). unpublished report DK-546. Bestimmung der|Auswirkungen von Malonsäurediethylester auf das|Schwimmverhalten von Daphnia magna (nach EG 84/449, Nov.|1989)|Degussa AG-Reg-Nr.: 93-0234-DGO.
Basler, A. et al.: Arch. Toxicol. 58, 10-13 (1985), No information
Genetic toxicity in vitro, IUC4#151/Ch.5.5
Essington ME (1994) Adsorption of aniline and toluidines on|montmorillonite. Soil Science 158 (3), 181-188.
Suzuki Y (1985) Studies on development of the sensitive|micronucleus test (Part 1) methods of induction by|polychlorinated biphenyl and of metabolic activation. Tokyo|Jikeikai Med J 100: 695 - 705
Method: other: test substance injected 5 d after a single i.p. injection of corn oil-dissolved polychlorinated biphenyl (PCB) to 6 week old BALB/c mice
Verrett, M.J., Scott, W.F., Reynaldo, E.F., Alterman, E.K.,|and Thomas, C.A. (1980) Toxicity and teratogenicity of food|additive chemicals in the developing chicken embryo. Toxicol|Appl. Pharmacol. 56:265-273.
Zhao Y, Yuan X, Ji G, Sheng L (1997) Quantitative|Structure-Activity Relationships of Nitroaromatic Compounds|to Four Aquatic Organisms. Chemosphere 34 (8): 1837 - 1844
Davis EM, Murray HE, Liehr JG, Powers EL (1981). Basic|microbial degradation rates and chemical byproducts of|selected organic compounds. Water Research 15, 1125-1127.
Method: other: according to Umbreit (1972)
Olsen, P. et al. (1986): Food Chem. Toxicol. 24, 1 - 12
Method: other: Two generation carcinogenicity study; the F1 generation being dosed for their entire lifespan (for further details see remark field and also chapter 5.8)
BASF AG (1964) Abt Toxikologie, unpublished report XIV/257, 29.09.1964.
Method: other: According to Modified OECD 201 (Algae, growth inhibition test, 1984)
Method: other (calculated): with KOWWIN v1.67
Epstein W-L. (1975) unpublished results, as quoted in Opdyke|DLJ (1976). Fd. cosmet. Toxicol., 14, 745-746.
Repeated dose toxicity: inhalation, IUC4#90/Ch.5.4
BASF (1970) Safety data sheet Mucochlorsaeure, D 034, July|1970, BASF AG
Vodela, J.K., Angerhofer, R.A., Michie, M.W., Leach, G.J.,|Reddy, G.: Effect of thiodiglycol (2,2'thiodiethanol) on|glutathione antioxidant system in rat erythrocytes. Environ.|Nutr. Interact. 3, 85-93 (1999)
Ishidate, M., Jr. & Odashima, S., Mutat. Res. 48, 337-354|(1977)
Agricultural University of Norway (2003). Department of|animal science. Tolerance study with sows. Effect of|pre-mating administra- tion of Formi LHS on|ovulation/fertility of breeding sows. Study report to|Project No. 818 545M (F-446) dated 27 June, 2003. Sponsored|by Norsk Hydro AS.
FMC Corporation, Acute toxicity of sodium persulfate to|grass shrimp (Palaemonetes pugio), Study no. I92-1253, 1993.
Method: other: in Anlehnung an Fassett, Eastman Kodak
Tamura, A., Yuri, H., Maruyama, H. and K. Maruyama (1968)|Clinical and Experimental Investigation of Ocular Damage|Caused by Trimethoxysilane. J Jap Opthalmol Soc 72(1):|40-47. Cited in AIHAJ Workplace Environmental Exposure Level|Guides: Trimethoxysilane (1997).
Bushy Run Research Center (BRRC) (1993). Union Carbide ®|Organofunctional Silane A-187: Developmental|Toxicity Gavage Study in New Zealand White Rabbits; BRRC|report number 91U0037, November 22, 1993.
Long-term toxicity to aquatic invertebrates, IUC4#70/Ch.4.5.2
Method: other: comparable to OECD guideline 472
Union Carbide Corporation. Bushy Run Research Center.,|Project Report No. 51-575. Export, PA. 1989
Acute toxicity: inhalation, IUC4#38/Ch.5.1.2
Viglino, L. and E. Pelletier. 2005. Butyltins in the waters of Saguenay Fjord (Canada): a threat for a semi-enclosed aquatic ecosystem? Revue des Sciences de l'eau. 19(1):11-22.
Pis'ko GT, Tolstopyatova GV, Barilyak IR, Gudz OV, Korkach, VI, Samoilov AP (1982). Substantiation of the Maximum Permissible Concentration of 4,4-Dichlorophenylsulfone in Reservoir Water. Gig. Sanit. Vol. ISS 2, pp. 84-85.
IBL (1965). Repeated Insult Patch Test. Industrial Biology|Laboratories. Unpublished report # 2799. July 21, 1965.
Method: other: Shelanski Repeated Insult Patch Test
J. Toxicol. Env. Health 16, 811, (1985): zit. nach RTECS,|update 8909
Acute toxicity: inhalation, IUC4#63/Ch.5.1.2
Nelson, BK., Brightwell, WS., Kahn, A., Burg, JR. and Goad,|PT. Lack of selective developmental toxicity of three|butanol isomers administered by inhalation to rats.|Fundamental and Applied Toxicology. 12(3):469-479.,1989b.
Vogel EW (1985) The Drosophila somatic recombination and|mutation assay (SRM) using the white-coral eye color system.|Prog Mut Res 5: 313-317
Method: other: Becker, H.J. (1966): Curr. Topics Develop. Biol. 1,155-171
Test on biodegradability of HCFC-124 by microorganisms|(Closed bottle method), Krume Research Laboratories, Japan,|Test No., 12102, January 1992
JETOC (1996). Mutagenicity test data of existing chemical|substances. Based on the toxicity investigation system of|the Industrial Safety and Health Law. Japan Chemical|Industry Ecology-Toxicology & Information Center. Ministry|of Labour, Japan. as cited in BIBRA working group.|2-Hydroxy-3-Naphthoic Acid. Toxicity profile. BIBRA|International, 1999
Kirk-Othmer Encyclopedia of Chemical Technology.: New York,|NY. John Wiley and Sons, 1985
Schering AG. Systemische Verträglichkeitsprüfung bei einmaliger Verabreichung (DL50). Prot.-Nr.: 2225. 20.1.1971.
Bantle J.A. et al., Phase III Interlaboratory study of FETAX|Part 3. FETAX validation using 12 compounds with and without|an exogenous metabolic activation system, Journal of Applied|toxicology 19, 447-472, 1999 (31)
Method: other: acute, static toxicity test
Poth A. Salmonella typhimurium reverse|mutation assay with FAT 65'023/L. Report CCR Project No.|231311; January 21, 1991. CCR Cytotest Cell Research GmbH &|Co. KG, Rossdorf, Germany.
Occupational Health Service center.(1973), Unpublished|report
Tohda, H. and Oikawa, A.: Mutat. Res. 201, 1-8 (1988);|cited in: RIFM database, location no. 9136
Hagiwara, A. et al.: J. Toxicol. Sciences 19, 189-195 (1994)
Method: other: According to the Protocol of the Dutch Standards Organisation, NEN 6502 (1980)
BASF AG, Safety data sheet MUCOCHLORSäURE TECHN., 15.10.2001
BASF AG, notification by Analytical Department, (21.10.92)
Cofrac ESSAIS (1999) Methyl 3-mercaptopropionate: Acute|Toxicity to Daphnia. Report number 512/99/A.
Dowden, B.F., Bennett, H.J. (1965). Toxicity of selected|chemicals to certain animals. J. Water Pollut. Control Fed.|37(9):1308-1316.
Celma PJ, Carrió R, and Garcia C (1997). El ensayo de|toxicidad Microtox y sus consecuencias. Estudio de la|toxicidad se algunas sales de cromo. AQEIC 3, 120-124.
IIT Research Institute. 1993. Dermal Sensitization Study|of Trimellitic anhydride in Guinea Pigs Using the Modified|Buehler Method. Study No. 1
Method: other: Modified Buehler Dermal Sensitization
Melting point/freezing point, IUC4#94/Ch.2.1
Proposed Guidelines of the US EPA 40CFR 163.81-5 'Primary dermal irritation study'
Hanstveit, R. 2003. 1,3,2-Dioxastannepin-4,7-dione, 2,2-dibutyl- (CAS# 78-04-6, Dibutyltin maleate, DBTM): Determination of the ready biodegradability in a Manometric Respiration Test. TNO Report V4017/01. September 2003.
Smets BF and Mueller RJ (2001). Metabolism of|2,4-dinitrotoluene (2,4-DNT) by Alcaligenes sp. Js867 under|oxygen limited conditions. Biodegradation 12(4), 209-217.
Method: other: Batch removal experiments under aerobic and anaerobic conditions
Wiebe J., The control of male fertility by|1,2,3-trihydroxypropane (THP;glycerol): rapid arrest of|spermatogenesis without altering libido, acessory organs,|gonadal steroidogenesis, and serum testerone, LH and FSH,|Contraception 29(3): 291-303, 1984
Toxicity to reproduction, IUC4#14/Ch.5.8.1
Valencia R, Abrahmason S, Wagoner P, Mansfield L (1973)|Testing for food additive-induced mutations in Drosophila|melanogaster. Mutat Res 21: 240-241
BASF (1983) Mutagenicity evaluation of Mucochlorsaeure in|the mouse lymphoma forward mutation assay (82/259). BASF AG,|Department of Toxicology, 02.08.1983 (unpublished data)
Method: other: in accordance with Clive, D. and Spector, J.F.S.: Mut.Res., 31, 17-29 (1975) (comparable to OECD 476)
American Conference of Governmental Industrial Hygienists|(1986) Documentation of the Threshold Limit Values and|Biological Exposure Indices. 5th ed. Cincinnati, OH:|American Conference of Governmental Industrial Hygienists,|1986., p. 396
Boyd, E.M.: J. New Drugs 5, 252 (1965);|cited in: Schlede, E. et al.: Arch. Toxicol. 66, 455-470|(1992)
Lan C-H, Peng C-Y, and Lin T-S (2004). Acute Aquatic|Toxicity of N-Methyl-2-Pyrrolidinone to Daphnia magna. Bull.|Environ. Contam. Toxicol. 73, 392-397.
Vogel, R. and Spielmann, H.: Teratogen. Carcinogen. Mutagen.|7 (2), 169-174 (1987);|cited in: RIFM database, location no. 5641
Leuschner, F. and Schwerdtfeger, W.: Coffein und andere|Methylxanthine, Int. Symp., Erlangen, FRG, 209-215 (1968)
Huntingdon Research Centre Ltd. (1988) Irritant effects on|rabbit skin of Isobutyltriethoxysilane. Report 87425D/DNN|13/SE. Degussa-Huls AG-Nr.: 88-0351-FGT August 31, 1988
Maronpot RR et al. (2000) Toxicology 146(2-3):149-59 **PEER REVIEWED** as cited in the National Library of Medicine (NLM) Hazardous Substance Data Bank (HSDB) and the Concise International Chemical Assessment Document 71, Resorcinol.
Method: other: respirometric diluting method
3-(triethoxysilyl)propiononitrile (IUC4 DSN 98)
BASF (1993): Determination of the chronic toxicity of|Natriumdisulfit to the water flea Daphnia magna STRAUS.|Proj. No. 93/2057/51/1
Hughes TD: Nitrogen Release from Isobutylidene Diurea: Soil|pH and Fertilizer Particle Size Effects. Agron. J. 68,|103-106 (1976)
BASF AG, Analytisches Labor; unveroeffentlichte Untersu-|chungen (BRU 88.145 vom 29.07.1988)
Garry, V.F. et al.: Environ. Mutagen. 3, 341 (1981);|abstract Ab-10, No information
Genetic toxicity in vitro, IUC4#156/Ch.5.5
USES v3.0, RIVM (1999): Uniform System for the Evaluation of|Substances (USES). RIVM [Rijksinstituut voor Volksgezondheid|en Milieuhygiëne; Dutch Institute for Public Health and the|Environment], Bilthoven, The Netherlands.
Segers, J.H.L., Temmink, J.H.M., Van den Berg, J.H.J.,|Wegman, R.C.C., 1984. Morphological changes in the gill of|carp (Cyprinus carpio L.) exposed to acutely toxic|concentrations of methyl bromide. Water Res,, 18:1437-1441.
Method: other: differential killing assay according Green and Tweats, 1979
Tompkins JA and Tsai C (1976) Trans Amer Fish Soc, 105,|313-321
Dupont de Nemours (1979b) Mutagenic activity in the|salmonella/microsome assay. Haskell Lab. Rep.-No. 275-79:|EPA-OTS0557126
Method: other: according to Ames et al., Mutat. Res. 31: 347 (1975), negative and positive controls (2-AA, MNNG, 9-AA, 2NF), incubation time: 48 hrs
Bacillus subtilis strains HLL3g (wild-type) and HJ-15 (repair deficient)
Jenkins TF (1989) Development of an analytical method for|the determination of extractable nitroaromatics and|nitramines in soils. Ph D thesis.Univ of New Hampshire,|Durham NH
Literature Search; Great Lakes Corporation and The Dow|Chemical Company, 1992
BASF AG, Safety data sheet, Choline chloride solution 75%,|25 Nov. 2002
Noda, T. Yamano,T. Shimizu, M and S. Morita. (1994). Effects of Tri-n-Butyl Phosphate on Pregnancy in Rats. FD. Chem. Toxic., 32, No.11, 1031-1036.
RCC Ltd. (2005) Determination of the Partition |Coefficient (N-Octanol/Water) of 3-mercaptopropanoic |acid methyl ester (MMP). RCC Study Number 858402. |June 16, 2005.
USEPA. 2000. KOWWIN. Version 1.67. Estimation Programs Interface (EPI) Suite. Office of Pollution Prevention Toxics (OPPTS) and Syracuse Research Corporation (SRC).
Hunt, Elizabeth K., Sandra Reiss Murphy, Tipton R. Tyler. |Health Effect Assessments of the Basic Acrylates. Page 94.| CRC Press. Boca Raton. 1993.
BASF (1980) Acute 4-hour inhalation toxicity in rats|(77/164). BASF AG, Department of Toxicology, 24.12.1980|(unpublished data)
Method: other: dynamic inhalation test with head-nose only exposure and analytical monitoring
Hoffmann-LaRoche (1975). Prüfung im 5 Tage Toxizitätsversuch|an Ratten, unpublished report, 10 Nov. 1975
MITI (1992) Biodegradation and Bioaccumulation Data of Existing Chemicals Based on the CSCL Japan, Compiled under the Supervision of Chemical Products Safety Division, Basic Industries Bureau, MITI, Published by Japan Chemical Industry Ecology-Toxicology & Information Center, p 2-26.
Hill, T. (2006) SEHSC Scientific Programs Manager, Herndon, Virginia. Personal Communication
Wangenheim, J. and Bolcsfoldi G.: Mutagenesis 3, 193-205|(1988), No information
Nippon Soda Co., LTD. (1985), unpublished report
Domanska U and Lachwa J (2002). (Solid + liquid) phase|equilibria of binary mixtures containing|N-methyl-2-pyrrolidinone and long-chain n-alkanols at|atmospheric pressure. Fluid Phase Equilibria 198, 1-14.
Vind, H.P. and H. Hochman. 1962. Proc. Am. Wood Pres. Assoc. 58:170. IN The Handbook of Environmental Chemistry. 1990. O. Hutzinger (ed.). Vol. 3, Part E. Anthropogenic Compounds. Springer-Verlag. Berlin, Germany.
2-methoxy-1-methylethyl acetate (IUC4 DSN 53)
Method: other: Respirometrischer Test mit Sapromat [Respirometer test with Sapromat]
Baker RS, Bonin AM (1985) Tests with Salmonella|plate-incorporation assay. Prog Mut Res 5: 177-180
Method: other: modified to Maron and Ames (1983), Mutat. Res. 48, 271; see also freetext TC
Huntingdon Life Sciences Ltd. (1999). Tungsten carbide|powder - Pure. Skin irritation to the rabbit. Unpublished|Report No. ITU 016/982643/SE, September 8, 1999.
Gomes-Carneiro MR, De-Oliveira ACAX, De-Carvalho RR, Araujo|IB, Souza CAM, Kuriyama SN and Paumgartten FJR (2003).|Inhibition of cyclophosphamide-induced teratogenesis by|beta-ionone, Toxicology Letters 138, 205-213
Ma WC, Brussaard L, De Ridder JA (1990). Long-term Effects|of Nitrogenous Fertilizers on Grassland Earthworms|(Oligochaeta: Lumbricidae): Their Relation to Soil|Acidification. Agric., Ecosystems and Env. 30, 71-80.
Heisler E and Dickhaus S (1993). Pruefung von Betolin K35|auf|primaere Hautreizwirkung beim Kaninchen nach Draize.|Pharmatox Beratung und Forschung GmbH, Report no. 3-59-93.
BASF AG, Department of Ecology, unpublished calculation,|11.06.1997
Hazleton Laboratories America, Inc. (1983) Mouse Lymphoma|Forward Mutation Assay with Methyl Mercaptoprionate. Project|No. 652-146.
Method: other: similar to OECD 476 and EPA OPPTS 870.5300
Vieluf, D. et al., Arch. Dermatol. Res. 281, 544-591 (1990)
Pharmatox (1994) Skin sensitization potential of 1-6403|Alkoxysilane in the guinea pig - Pharmatox-|T1678, Pharmatox, Round Corner, NSW, Australia, 1994 as|cited in Worksafe Australia (1995).
IUCLID, 1996. International Uniform Chemical Information|Database. Database generated and maintained by the European|Chemicals Bureau for Existing Chemicals, Edition 1 - 1996,|European Commission.
Method: other (measured): stripping experiments in an aerated stirred reactor
Salmonella typhimurium TA100/1535/1537/1538
Method: other: Closed Bottle Test (according to later OECD 301 D Guide-line)
Litton Bionetics Inc. (1980) Mutagenicity Evaluation of 3,4-Diaminotoluene in the Mouse Lymphoma Forward Mutation Assay, Final Report, EPA Document No 878214427, Fiche No. OTS0206567. (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com)
Mullee, D.M & Woolley, S.M.(2002). Safepharm Laboratories Ltd., N-tert-butylbenzothiazole-2-sulphenamide: determination of general physico-chemico properties, report No. 1723/002
Amlacher E (1982) Short-term test in screening programs of|environmental chemical carcinogens. Exp Path 22: 187-202
Method: other: thymidine incorporation inhibiting screening system
Oikawa A. et al. (1980). Biochem. biophys. Res. Commun. 97,1311.
Malley L.A. et al (1995) Foundamental and Applied Toxicology|28, 80-93
Chemicals Biotesting Centre, Chemicals Evaluation and|Research Institute (CERI), Japan (2004). Personal|communication (14.09.2004) with Mr. K. Kawahara, : Email|with attached robust summary from Mitsubishi Chemical Safety|Institute, Japan (2002). Report of Biodegradability study on|K-1598, Report No. A010213.
Method: other: according to Schmid, W.: Mutat. Res. 31, 9-15
Genetic toxicity in vivo, IUC4#45/Ch.5.6
Method: other: according to NTP protocol
Federal Register (1982) Phenyldiamines: response to InteragencyTesting Committee. 47, 973.
Schultz TW, Kissel TS, Tichy M (1994). Structure-toxicity|relationships for unsaturated alcohols to Tetrahymena|pyriformis: 3-alkyn-1-ols and 2-alken-1-ols. Bulletin of|Environmental Contamination and Toxicology 53, 179-185
Weinstein, D. et al.: Mutat. Res. 31, 57-61 (1975);|cited in: RIFM database, location no. 7117
Toxicity to terrestrial plants, IUC4#34/Ch.4.6.2
Thurston RV, Gilfoil TA, Meyn EL, Zajdel RK, Aoki TI, Veith|GD. 1985. Comparative toxicity of ten organic chemicals to|ten common aquatic species. Water Res 19:1145-1155.
Method: other: APHA(1980) or USEPA (1974)
Nishioka, H.: Mutat. Res. 17, 261-265 (1973), No information
Aeschbacher, H.U. et al.: Fd. Chem. Toxic. 27, 227-232|(1989)
Method: other: according to Yahagi, T.: Mutation Research 48, 121 (1977)
de Wolf, J.M. 2004. Abiotic degradation of Trichloromethylstannane (CAS# 993-16-8) and Dichlorodimethylstannane (CAS# 753-73-1) according to OECD test guideline 111 - a preliminary test (Tier 1). TNO Nutrition and Food Research. TNO report V4739. 18 June 2004.
BASF AG, Department of Toxicology, unpublished results,|(ZST No. 77/585), 07 Nov. 1978
BASF AG, Technical Information BUTYL ACRYLATE, October 2005
Hepatocytes from male rat: Tif.RAIf (SPF), weight 250g
Siboulet, R. et al.: Mutat. Res. 125, 275-281 (1984), No information
Johnson, R.C. and Baillie, D.L.: Mutat. Res. 201, 137-147|(1988), No information
DeMarco, A. and Cozzi, R.: Mutat. Res. 69, 55-69 (1980)
Stolzenberg, S. J., Hine, C. H., Mutagenicity of halogenated|and oxygenated three-carbon compounds, J. of Toxicol. and|Environment. Health, Vol. 5, 1149-1158, (1979) (11).
Muermann P. 1990. Pruefung der akuten Augen- and Schleimhautreizwirking von Ethyldiglykolacetat. [Test of acute eye and mucous skin irritation for ethyldiglycol acetate]. Huls Report Number 1751, dated Sept 11, 1990.
Dow Corning Corporation (1964) The effect of the Alkyl Group|in the Acetoxy Cross-Linking System. Dow Corning Report No.|1964-I0030-2409.
Galloway, S.M. et al. (1987): Environ. Mol. Mutagen. 10,|Suppl. 10, 1 - 175
Bayer AG (1989). Biodegradation of 1,4-Dichloro-2-butene. Unpublished Report, No. 60 A/88.
Method: other: EG Richtlinie 79/831 EWG, Anhang V
Phillips, J.E., Quast, J.F., Miller, R.R., Calhoun, L.L.,|Dittenber, D.A., (1985) Ethylene glycol phenyl ether and|propylene glycol phenyl ether: Comparative 2-week dermal|toxicity study in female rabbits. Dow Study No.|HET-T2.2-192-(5)P & K-5220-(5)PV. December 19, 1985. |Unpublished.
Method: other: Not specified. Generally follows EPA Protocol Guideline 870.3200 "21/28-Day dermal toxicity"
Demkowics-Dobrzanzski, K. and Castonguay, A.:|Carcinogenesis13, 1447-1454 (1992), No information
Genetic toxicity in vitro, IUC4#199/Ch.5.5
Rudio J (1999): Partition coefficient n-octanol/water of|Isophytol according to OECD Guideline No. 117. Test Report|no. 99-E102. Givaudan-Roure SA, CH-1214 Vernier/Geneva,|Switzerland, Nov 11, 1999 (unpublished).
Kronberg L, Karlsson S, Sjöholm R (1993). Formation of|ethenocarbaldehyde derivatives of adenosine and cytidine in|reactions with mucochloric acid. Chem. Res. Toxicol. 6:|495-499.
Genetic toxicity in vitro, IUC4#52/Ch.5.5
Short-term toxicity to fish, IUC4#35/Ch.4.1
TNO (1978) Eye Irritation Tests for four Peroxides in Albino|Rabbits. Central Institute for Nutrition and Food, TNO.|Study #: R5797. Study Date: September, 1978.
Method: other: Federal Hazardous Substances Act, Chapter II, Title 16 CFR and Draize (1952)
SAX's dangerous properties of industrial materials, Van|Nostrand Reinhold, 1996.
Biodegradation in water and sediment: simulation tests, IUC4#7/Ch.3.5
Method: other: acute immobilisation test
Hoechst AG (1973): Unveroeffentlichte Untersuchung (73.0149)
Method: other: method from the laboratory, 5 animals per dose
Method: T26-16:10 rats/sex and dose group,
Bogers M., 1998, 96-hour acute toxicity study with lynalylacetate (flow-through), NOTOX
IARC Monographs on the Evaluation of Carcinogenic Risks to|Humans, Vol. 51, Lyon, France (1991); pp. 291-390
BASF AG, Department of Toxicology, Report on the acute|toxicity; unpublished study (86/173). Dec 19, 1986
Method: other: OECD guideline 203 (1984)
Handbook of Environmental Data on Organic Chemicals (2001).|4th edition, John Wiley & Sons, Inc., New York, USA.
Iversen, O.H.: Environment International 12, 541-544 (1986), No information
BASF AG (1976). Department of Ecology, study No. 01262 123|(unpublished).
Daubert, T.E., and Danner, Physical and Thermodynamic|Properties of Pure Chemical Data Compilation. Washington|D.C..: Taylor and Francis 1989; HSDB 2001.
Barlow SM, Sullivan FM (1982). Reproductive Hazards of|Industrial Chemicals: 553-555
Salmonella typhimurium TA97, TA98, TA100
NMP Producers group (1999c). Two-generation reproduction toxicity study with N-Methylpyrrolidone (NMP) in Sprague-Dawley rats - Administration in the diet. Huntingdon Life Science, East Millestone, NJ, USA, project No.: 97-4106, unpublished study
Zeiger E, Margolin BH (2000): The proportions of mutagens|among chemicals in commerce. Regul Toxicol Pharmacol 32:|219-225.
Method: other: as described by Zeiger et al. (1992): Environ Mol Mutagen 19(suppl. 21): 1-141
Gonsior SJ (1990) "Environmental assessment for glycol ethers", unpublished report of Dow Chemical Company.
Biodegradation in water and sediment: simulation tests, IUC4#90/Ch.3.5
Method: other: according to: Code of Federal Regulations, Title 16, Section 1500.42 see also freetext ME
Pitter P (1976). Determination of biological degradability|of organic substances. Water Res. 10, 231-235.
Method: other: batch system (comparable to Zahn-Wellens Test OECD TG 302B)
BASF AG, department of product safety, regulations,
Method: other: according to Deichmann-LeBlanc, J. industr. 25, 415 (1943), gross pathology, histol. examination, post exposure observation: 14 d, number of animals/group is missing
Alexandrow IS (1936) Über die relative toxische Wirkung der|aromatischen Amino- und Nitroverbindungen auf weiße Mäuse|durch die Haut. Journal Physiol USSR 20: 1100-1109
Ishidate, M. & Odashima, S. Chromosome tests with 134 compounds on chinese hamster fibroblast cells in vitro - A screening for chemical carcinogenes. Mutation Research. 48, 337-354, 1977
Leach, C.L., Hatoum, N.S., Ratajczak, H.V., Zeiss, C.R.,|Roger JC, and Garvin, P.J. 1987. The pathologic and|Immunologic Repsonse to Inhaled Trimellitic Anhydride in|Rats. Toxicol Appl Pharmacol. 87(1):67-80
Shimizu , H., Suzuki, Y., Takemura, N., Goto, S. and|Matsushita, H. (1985): The results of microbial mutation|test for forty three industrial chemicals. Jnp J Ind Hlth,|27, 400-417.
Method: other: according to Ames et al. (1975)
Wiebe et. al. Contraception, vol. 39, p. 447, 1989.
Van den Dikkenberg RP, Canton HH, Mathijssen-Spiekman LAM,|Roghair CJ (1989). Usefulness of Gasterosteus aculeatus -|the three-spined Sticklebacks as a Test Organism in Routine|Toxicity Tests. Report, Order No. PB90-244989, Avail. NTIS,|Rijksinst. Volksgezond. Milieuhyg., Bilthoven, Neth., 28 pp.
Method: other: Short term toxicity tests according to Adema , report RIV 627905 001, National Institute of Public Health and Environmental Protection, Bilthoven, Netherlands
Method: other (calculated): with KOWWIN, v.1.66
Genetic toxicity in vitro, IUC4#163/Ch.5.5
Remde, A. and Debus, R.: Biodegradability of Fluorinated|Surfactants under Aerobic and Anaerobic conditions,|Chemosphere, 32, No.8, 1563-1574(1996)
Method: other: OECD guide-line "Ready biodegradability test"
Hüls AG (1992c). In vitro mammalian cell gene mutation assay|(HPRT-test) with Vestamin IPD. Report No. HP-92/0046|(unpublished).
Method: other: OECD Guideline 476 (1984)
Takeda Chemical Industries Ltd., Japan (1966), 1302392,|Fukuda et al. (1971).
Gronemeyer, W. (1939), Allergische Reaktion gegen Menthol,|Deutsche Medizinische Wochenschrift 65, 756-757
Safepharm Laboratories Ltd., Derby (1993): Benzoguanamine, Ninety Day Sub-Chronic Oral (Dietary) Toxicity Study in the Rat. Project No. 521/3
Schering AG. 1989. The Effect of ZK 24.942 on the Growth of the Bacterium Pseudomonas putida. Study conducted by the Department of Biology, TNO Division of Technology for Society, Delft, NL. Report No. R 89/251. 10.08.1989.
Method: other: Umweltbundesamt Guideline "Bewertung wassergefährdender Stoffe"
Krul, C.A.M. 2002. Bacterial reverse mutation test with trichloromethylstannane. Report V 3405/21. Department of Biomolecular Sciences, TNO Food and Nutrition Research, 3700AJ Zeist, The Netherlands. 28 March 2002.
Method: other: rat mean weight: 200 g, food and water ad libitum, appl. by gavage, dosing volume: 1 ml, 5 different doses, post dose observation period: 14 d, statistical evaluation according to Bartlett, determination of LD50 with probit meth
National Toxicology Program (1995) Chromosome |Aberrations Study ID A81034|http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=|invitroca.cadata&study_no=A81034&cas_no=999%2D97%|2D3&endpointlist=CAB
BASF AG, Analytical department, unpublished report, J.Nr.|34-762, 26.02.79
DuPont Chem (1972) Class B poison test on rabbit skin with|oluene, para-nitro. April 5, 1972: NTIS/OTS 0572885
Method: other: TS was applied to the clipped dorsal skin for 24 hours and wrapped with a layer, stretch gauze bandage and elastic adhesive tape. Afterwards wrapping was removend, skin washed with water and dried; further observation: 48 hours
Mobay Chemical Corporation (1984a). Sensory irritation of isophorone diisocyanate (IPDI) to mice, study number 82-341-01. Report 538. Mobay Chemical Corporation (Metcalf, Stilwell, KS, USA).
Jones CA, et al. (1988) An interlaboratory evaluation of the|Syrian hamster embryo cell transformation assay using|eighteen coded chemicals. Toxic in vitro 2: 103-116
Method: other: modified Ames gradient plate (McMahon, 1979)
CRC Handbook of Chemistry and Physics. 81st Edition. CRC|Press LLC, Boca Raton: FL 20003-170
Hardin B.D. et al, 1981, Scand. J. Work Environ. Health,|V7 (suppl.4), P.66-75.
Gilbert P, Saint-Ruf G, Poncelet F, Mercier M (1980) Genetic|effects of chlorinated anilines and azobenzenes on|salmonella typhimurium. Arch Environ Contam Toxicol 9:|533-541
Method: other: (1) plate incorporation method, incubation 48 hours, in aerobic and in anaerobic conditions, solvent: ethanol abs., duplicates (2) bacterial fluctuation test, incubation 72 hours, solvent: ethanol abs., triplicates
BASF AG, Department of Product Safety, Laboratory of|Ecology, Prüfung der Atmungshemmung von Belebtschlamm durch|2-Methylhepten-2-on-6 im Kurzzeitatmungshemmtest,|unpublished report, 95/0224/08/1, 08 May 1995
Hazleton Laboratories America, Inc. (1987) Acute Inhalation|Toxicity Study in Rats. Methyl Mercaptopropionate. Project|No. 5443-543/2.
Method: other: similar to OECD 403 and OPPTS 870.130
IITRI. 1991a. Acute oral toxicity study of trimellitic|anhydride in rats. Final Report. IITRI Project NO. L08100,|Study No. 1699, Test Article No. 128I.
Ciba (1981). Acute Oral LD50 in the Rat of TK 10027.|Unpublished report # 811496. December 18, 1981.
Chemicals Evaluation and Research Institute (2004).|Hydrolysis Rate of 4-ethylmorpholine. Report Number 805292.
Hüls AG (1993a). Determination of the mutagenicity of isophorone diisocyanate (IPDI) in the Ames Salmonella/mammalian microsomes mutagenicity test complying with Directive 84/449/EEC B.14. Report No. AM-84/25 (unpublished).
Dow Corning Corporation Internal Report Number|1982-I0005-1017
Method: other: Basis for later German DIN 38412-8 (cell multiplication inhibition test)
CIBA-GEIGY, Ltd. 1982. Report on Skin Irritation in the Rabbit after Single Application of TK 10422. Project No.: 811810. 22.04.1982.
Method: other: EPA, §163.81.5, Federal Register Vol. 43, No. 163, August 22, 1978
Springborn Smithers Laboratories (2004) Trimethoxysiloxane |Acute Toxicity to Rainbow Trout (Oncorhynchus mykiss) Under|Static Conditions. Wareham, MA. ReportNo. 12023.6145.
BASF AG, Product Specification THIODIGLYKOL ULTRA,|17.06.2002
Method: other: pH value determined according to DIN 19268
Loeser, E., Bayer AG data, Akute orale Toxizitaet (1977)
Grosjean E., Grosjean D. and J.H. Seinfield. 1996. Int. J.|Chem. Kinet. 28., 373-382.
Bruno Bock Chemische Fabrik GmbH (2000) Determination of the|boiling point.
Beynon, R. J.; Easterby, J. S. (1996) The Basics: Buffer|Solutions|1996.
Schering. 1993. Activated sludge, respiration inhibition test of ZK 24.942 (Tetra-n-butyltin). IC Research Report No. IC 5/92. 24.04.1993.
Method: other: OECD Guideline 209 (1984); ISO 8192 (1986)
Alarie Y (1973). Sensory irritation of the upper airways by|airborne chemicals. Toxicol Appl Pharmacol 24, 279.
Monsanto Co. (1987) Rat teratology study with nitrated|orthene (report no. ML-84-104). Monsanto Co., St. Louis|(OTS0524331, 88-900000145)
Friedrich, C.G. et al. (2001): Oxidation of Reduced|Inorganic Sulfur Compounds by Bacteria: Emergence of a|Common Mechanism? Appl. Environ. Microbiol. 67(7), 2873-2882
Fujita T, Iwasa J, Hansch C (1964) A New Substituent|Constant Derived from Partition Coefficients. J Am Chem Soc|85: 5175 - 5180
Utakoji T. et al. (1979). Biochem. biophys. Res. Commun. 90, 1147.
L5178Y mouse lymphoma cells, heterozygous at the TK locus
Jungclaus, G.A. et al., Environ. Sci. Technol. 12, 88-96|(1978)
Curtis MW, Ward CH (1981) Aquatic Toxicity of Forty Industrial Chemicals: Testing in Support of Hazardous Substance Spill Prevention Regulation. Journal of Hydrology, 51: 359-367 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Berthezene F, Perrot L, Munary Y, Ponsin G (1979) Multiple effects of resorcinol on thyroid function. Annals of Endocrinology (Paris) 40:67-68.
Haworth T, Lawlor T, Mortelmans K, Speck W, Zeiger E (1983)|Salmonella mutagenicity test results for 250 chemicals.|Environ Mutagen Suppl 1: 3-142
Method: other: preincubation protocol according to Ames, Mutat. Res. 31, 347 (1975) positive control, solvent control, S9 from male Sprague-Dawley rat and male Syrian hamster livers, 2 trials each (see also freetext Method)
Auletta, C.S., Kotkoskie, L.A., Saulog, T., and Richter, W.R. |(1998). A Dietary Oncogenicity Study of Tributyl Phosphate in the Mouse. Toxicology 128, 135-141. and Pharmaco. 1994. An Oncogencity Study of Tributyl Phosphate in the Mouse Via Dietary administration. Project No. 89-3532. (at the request of Synthetic Organic Chemical Manufacturers Association Inc.)
Method: other: US EPA/TSCA Guideline No. 798.3300
Degussa AG, unpublished, Report No.: Degussa AG, US-IT-Nr.|83-0024-DKT (1983).
BASF AG, Laboratory of Ecology, unpublished data, No.1067/7|(1980)
Method: F26-25:Standversuch nach Zahn Wellens
Scopas Technology Company (1986). Mutagenicity evaluation of|chlorine dioxide in the mouse lymphoma forward mutation|assay Litton Bionetics Inc, report n°= 20989.
EPA OTS 798.5300 (Detection of Gene Mutations in Somatic Cells in Culture)
Hüls AG (1985). Prüfung der akuten Hautreizwirkung von|Laurinlactam. Report No. 0353 (unpublished)
Method: other: OECD Guideline 404 "Acute Dermal Irritation/Corrosion" (1981)
Tokumo, K. et al. (1991): Cancer Lett. 59, 193 - 199
Method: other: Liver Carcinogenesis Promotion Assay
Environmental Health Bureau, The Japanese Ministry of Health|and Welfare: Report on one-generation reproduction toxicity|study of 2-naphthol by oral administration in|rats. Hatano Research Institute, Food and Drug Safety|Centre, HRI Report No. 10-1638. Sep 4, 2000.
Short-term toxicity to fish, IUC4#21/Ch.4.1
Cleveland C and Yavitt J (1998). Microbial consumption of|atmospheric isoprene in a temperate forest soil, Applied|Environ. Microbiol., Vol 64, pp. 172-177.
Food and Drug Research Laboratories, Inc. (1977) |Report Submitted to General Electric Co. Acute |Inhalation Study in Rats, Laboratory No. 5547. |February 9, 1978.
Method: other: Two-year oral feeding study
Durlacher, S.H., Harrison, W., Jr. and Darrow, D.C. (1946)|The effects of calcium chloride and of calcium lactate|administered by gavage. Yale J. Biol. Med., 18, 135-143.
Wiegand H.J. et al.: Arch. Toxicol. 63, 250-251, (1989)
Singletary, K.W. et al. (1992): Food Chem. Toxicol. 30,|455 - 465
Merck (1993) Chemikalien Merck,|Thioglykolsaeure-2-aethylhexylester (ohne Jahreszahl),|zitiert in: BG-Chemie, Toxikologische Bewertungen Nr. 83,|Thioglycolsaeure-2-ethylhexylester (1993)
NTP (National Center for Toxicologial Research): Acute|Toxicity Report On Caffeine|(3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione) in B6C3F1|Mice, Final Report, NCTR Techn. Rep. for Expt. No. 365 (NTP|Expt. No. 0501101) (1982b)
Heisler E and Dickhaus S (1993). Pruefung auf lokale|Vertraeglichkeit einer Betolin K35 als 25%ige Verduennung am|Kaninchenauge. Pharmatox Beratung und Forschung GmbH, Report|no. 3-62-93.
BASF AG, Department of Toxicology; unpublished study|(89/183), 15.05.90
Simmon, V.F., Kauhanen, K., and Tardiff, R.G.: Dev. Toxicol.|Environ. Sci. 2:249-258 (1977).
Kaniwa, M.-A. et al., Contact Dermatitis 30, 26-34 (1994)
Method: other: Internal Union Carbide method for skin irritation.
Römpp (1998) Römpp Lexion Chemie (10. Auflage), G. Thieme|Verlag, Stuttgart
Leung HW and Paustenbach DJ: Techniques for estimating the|percutaneous absorption of chemicals due to environmental|and occupational exposure. Appl. Environ. Occup. Hyg. 9,|187-197 (1994) as cited in Paustenbach DJ: The Practice of|Exposure Assessment: A state-of-the-art Review. J Toxicol|Env Health B, 3, 179-291 (2000)
Short-term toxicity to aquatic invertebrates, IUC4#18/Ch.4.2
Method: other (calculated): MPBPWIN v.1.41, 2000
Ono Y, Somiya I and Kawamura K (1991). The evaluation of|genotoxicity using DNA repairing test for chemicals produced|in chlorination and ozonation process. Water Sci. Technol.|23, 329-338.
Heil, J. et al., Mutation Research 368, 181-194 (1996)
Calculated with AOP V 1.89|Syracuse Atmospheric Oxidation Programme W. Meylan |and P.Howard Syracuse Research Corporation
Atkinson R (1985). Kinetics and mechanisms of the gas-phase|reactions of the hydroxyl radical with organic compounds|under atmospheric conditions. Chem. Rev. 85, 69-201.
Clarke CW and Aldons PM (1981). Isophorone diisocyanate induced respiratory disease (IPDI). Aust. N.Z. J. Med. 11, 290-292.
CERI (2004). Melting point study of Tetrahydrofurfuryl|alcohol: CAS No. 97-99-4. Test Number 805281. Unpublished|data.
Eder, E. et al., The possible role of alpha,|beta-unsaturated carbonyl compounds in mutagenesis and|carcinogenesis, Toxicology Letters, 67, 87-103 (1993)
OECD Guideline 304 A (Inherent Biodegradability in Soil)
Gupta, R.L. et al. (1989) Toxicol. Lett., 48, 75-81.
Salmonella typhimurium TA98, TA100, TA102
Industrial Biology Laboratories Inc, Shelanski MV (1964 b)|Repeated insult patch-test with Monsanto Chemical Company -|Stock No. 30-11-1. Results. Study report Project No.|SH-64-8. Unpublished study of Monsanto Chemical Co
Knovel Critical Tables Copyright: © 2003
Pitter P (1976) Determination of biological Degradability of Organic Substances, Water Research 10:231-235 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Adler, I.D.: Humangenetik 7, 137-148 (1969);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
BASF AG, Department of Toxicology, Report on the acute|irritation to the eye of beta-Ionone in white rabbits,|unpublished report, project no. 18H0245/912114, 13 May 1992
Bayer AG 1986a, Internal study: Test on vapour pressure|(12.06.1986)
Pitter P (1976) Determination of biological degradability of|organic substances. Water Research 10: 231 - 235
Method: other: similar to OECD 302B "Zahn-Wellens-Test"
Shirai, T. et al. (1991): Carcinogenesis 12, 1335 - 1339
Method: other: Multi-Organ Initiation/Promotion Assay
Method: other: CIBA-Geigy Internal Method B-10
National Toxicology Program(1987) Annual Plan for Fiscal Year, cited in IUCLID (2000)
Carrara G, Zoppellari I (1894). Velocità di reazione in|sistemi non omogenei. I. Descomposizione del cloruro di|solforile. Gazz. Chim. Ital. 24 (1), 364-370.
Method: other: non-homogeneous system according to Carrara and Zoppellari (1894)
Report No. CTL/P/1999, Ecological and Toxicological|Association of Dyes and Organic Pigments Manufacturers,|unpublished report
Daubert TE and Danner RP (1998). Physical and Thermodynamic|Properties of Pure Chemicals, Volume 4. Hemisphere Pub|Corp., New York.
Hays JT and Haden WW: Effect of Structure on Nitrification|of Urea Derivatives. J. Agr. Food Chem. 17, 1077-1079 (1969)
Le Coz C.J. & Schneider, G.A., Cont. Derm. 39, 39-40 (1998)
Genetic toxicity in vitro, IUC4#201/Ch.5.5
Salmonella typhimurium strains TA98 and|TA100
Bayer AG 1986c, Internal study: Modified MITI Test (I)|according to OECD Method 301 C (1986.04.28)
Method: other: Directive 84/449/EEC, C.3. Method was adapted to Assessement of Biodegradability of Chemicals in Water by Manometric Respirometry according to EU ring test
Yaws, C.L. 1994. Handbook of Vapor Pressure. Volume 2. C5-C7 Compounds. Gulf Publishing Company. Houston, TX.
BASF AG, Department of Toxicology, Bericht über die|Bestimmung der akuten Inhalationstoxizität LC50 von MBA als|Dampf bei 4stündiger Exposition an Sprague-Dawley-Ratten,|unpublished report (78/452), 21 May 1979
Sofuni T, Honma M, Hayashi M, Shimada H, Tanaka N, Wakuri S,|Awogi T, Yamamoto KI, Nishi Y and Nakadate M (1996).|Detection of in vitro clastogens and spindle poisons by the|mouse lymphoma assay using the microwell method: interim|report of an international collaborative study. Mutagenesis|11, 349-355.
Ministry of Health & Welfare, Japan (1999c): Toxicity Testing Reports of Environmental Chemicals, vol 7, 243-246, "Single Dose Oral Toxicity Test of 2,4-Diamino-6-phenyl-s-triazine in Rats".
Hüls AG (1992). Ps - Biology/Toxicology. Study report No.|10, 11 Mar 1992, unpublished.
Lien E., et al. Dipolarity and Partition Coefficient of|Solvents, Drugs and Chemicals, Quant Struct.-Act Relat|12:158-163, 1993
Obe, G. and Beck, B.: Drug and Alcohol Dependence 4, 91-94|(1979)
Bermudez E, Tillery D, Butterworth BE (1979). The effect of|2,4-Diaminotoluene and isomers of dinitrotoluene on|unscheduled DNA synthesis in primary rat hepatocytes.|Environmental Mutagenesis 1, 391-398.
Method: other: according to Williams G.M., Cancer Res 37, 1845-1851 (1977) treatment interval: 18 hours, fixed with 3 washes of acetic acid:ethanol=1:3
Andrews, A.W., Zawistowski and Valentine, C.R.: Mutat. Res.|40:273-276 (1976).
BOD5 Method: other: "Standard Dilution Method"
Jagiello GM, Lin JS, Ducayen MB (1975) SO2 and its|metabolite: Effects on mammalian egg chromosomes. Environm|Res 9: 84-93
Abernethy, D.J. et al.: Environ. Mutagen. 5, 419 (1983), No information
Young, Affleck (1974): Engl. Bull. Purdue Univ. Eng. Ext. |Ser. 145, 154-164
Biodegradation in water: screening tests, IUC4#46/Ch.3.5
Degussa-Huls AG (1995) Determination of the biodegradability|of DYNASYLAN ATAC In DOC-DIE AWAY TEST. Final Report DDA|108. Degussa-Huls AG-Nr.:95 0217 DGO. 10/19/95
Genetic toxicity in vitro, IUC4#134/Ch.5.5
Gulf Coast Research Laboratories. 1992. Life-cycle Toxicity of Dibutyltin Dichloride to the Sheepshead Minnow in a Flow-Through System. Contract No. ES-7339, Subtask 2D. Sponsored by the Consortium of Tributyltin Manufacturers [Atochem North America, Inc., King of Prussia, PA and Sherex Chemical Co., Inc., Dublin, OH]. October 27, 1992.
King, E.F. & Painter, H.A., Ring-test programme 1981-82.|Assessment of biodegradability of chemicals in water by|manometric respirometry, Commission of the European|Communities, Luxembourg, Contract No. W/81/217 (1983)
Barzel, U. S. and Jowsey, J.: The effects of chronic acid|and alkali administration on bone turnover in adult rats,|Clin. Sci., 36, 517-524, (1969)
Melting point/freezing point, IUC4#21/Ch.2.1
Takayama, S. and Kuwabara, N.: Gann 73, 365-371 (1982);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Method: other: 10/15 animals/group/sex for exposure, 5/15 for exposure and subsequent recovery
Eeken, J.C.J. and Sobels, F.H.: Mutat. Res. 175, 61-65|(1986), No information
Inui, H. et al., Chemosphere 6, 393-404 (1979)
Ciba-Geigy Ltd., Report on the emergence and growth test of|TK 10044 to terrestrial plants, Project No. 918133,|17.10.1991.
Method: other: similar to Directive 2000/32/EC, B.11
Mouse bone marrow micronucleus assay of HCFC-124, E.I. du|Pont de Nemours and Company, Haskell Laboratory for|Toxicology and Industrial Medicines, Delaware, USA, HLR No.|52-90, February 1990. ||Malley, L.A., Frame, S.R., Elliott, G.S., Bentley, K.S.,|Brock, W.J., Trochimowicz, H.J. and Rusch, G.M. Chronic|toxicity, oncogenicity, and mutagenicity studies with|chlorotetrafluoroethane (HCFC-124). Drug and Chem Toxicol,|Vol 21 (4), 417-447, 1998.
Method: other: EPA OTS 798.5395 and OECD draft guideline 474
Defitraces (2003) MMP boiling point. Unpublished report|No. 02-902003-060 from Defitraces for Thioesters|Association. 12 May 2003.
Dill, D.C. 1980. Evaluation of isooctyl thioglycolate (IOTG) in the aquatic environment. Unpublished Dow report.
Ikeda, T., 1980. Behavioral effects in rats following|repeated exposure to methyl bromide, Toxicol. Lett.|6:293-299.
Keeler P, Yokel H and Vaughn C (1976). Toxicological|properties of an isoprene process stream. The Dow Chemical|Company, Midland, MI, USA. (Unpublished report).|(Quoted in: Workplace Environmental Exposure Level Guide|Isoprene (1990). American Industrial Hygiene Association.)
Stafford W and Northup HJ (1955). The BOD of textile|chemiclas. American Dyestuff Reporter, May 23, 355-359.
BOD5 Method: other: sodium acid modification of the Winkler procedure
Biodegradation in water: screening tests, IUC4#6/Ch.3.6
Adler, I.D.: Humangenetik 3, 82-83 (1966)
JETOC (Japan Chemical Industry Ecology-Toxicology and|Information Center, Japan): mutagenicity test data of|existing chemical substances based on the toxicity|investigation system of the industrial safety and health|law, Jan. 1996
Method: other: OECD Guide-line 471, preincubation method, S9-mix from induced rat liver, solvent and positive controls (AF2, NaN3, 9AA)
Method: other: Code of Federal Regulations, Title 16, Section 1500.41
Clariant GmbH (1999): Unveröffentlichte Untersuchung der|InfraServ Gendorf, Fachbereich Umwelt, Abbau von Genamin LA|302 D, 9.02.99
American Cyanamid Company, |Dominant lethal mutagenicity study on Compound III in the|rat|unpublished report, Pharmacopathics Research Laboratories|1974
Salmonella typhimurium (strains TA98, TA100, TA1535, TA1537, and TA1538)
Method: T14-06:FIFRA Pesticide Assessment Guidelines, Subdivision F, Section 81-5, "Primary Dermal Irritaion Study "TSCA Health Effects Test Guidelines, "Acute Exposure, Primary dermal Irritation"
ABC Laboratories. Acute Toxicity of TBP to Rainbow Trout.|Study ID: AB-78-1384337-1d. Monsanto study AB-78-0386. (1978)
Sills,J.B and Allen,J.L.Prog. Fish Cult. 4, 67 - 68 (1979), No information
Method: other: static exposure followed by different depuration periods
Daubert, T.E., R.P. Danner. Physical and thermodynamic|Properties of Pure Chemicals Data Compilation. Washington,|D.C. : Taylor and Francis, 1989
Singh, H.B., Salas, L.J., Smith, A.J. and Shigeishi, H.:|Atmos. Environ 15:601-612 (1981).
Principe, J.M. (2000) Melting Point Determination of|Ethyltriacetoxysilane. Schenectady Materials and Processes|Laboratory, Inc.
Procter & Gamble Co.(1992b) Acute oral toxicity study in rats with B0837-01, B0838-01, B0839-01 and B0840-01. Hazleton Laboratories America, Inc. U.S.EPA/OPTS Public Files, Doc.I.D.88-920007038, OTS0537648.
Method: other: 0.5 ml undiluted TS into the conjunctival sac of the eye, number of rabbits not mentioned, control substance: sodium saline, reading : 1 hour, 24 hours and 8 days after application of TS
Malek F.A., Möritz K.-U., Paul I., Bienengräber V., and|Fanghänel J. Physical and motoric development of rats after|prenatal formaldehyde exposure. Teratology 58, 23A. 1998.|Ref Type: Abstract, No information
Slaga TJ, Triplett LL, Smith LH, Witschi HP (1985).|Carcinogenesis of nitrated toluenes and benzenes, skin and|lung tumor assays in mice. Final Report, Report-No. ORNL|TM-9645, Oak Ridge National Laboratory, Oak Ridge, Tennessee|37831, AD-A155723.
Method: other: lung tumour assay according to Shimkin M.B. and Stoner G:D., Adv. Cancer Res. 21, 1-58 (1975)
Mobay Chemical Corporation (1987b). The evaluation of isophorone diisocyanate for primary skin irritation in rabbits, NTIS/OTS Microfiche 0515403, Doc 86-870001244.
Berte F, Bianchi A, Gregotti C et al. 1986. In vivo and in vitro toxicity of Carbitol [Boll Chim Farm 125, 401-403. 1986] Chem Abstr 107 (3) 19235 1987.
O'Connor, P.M. and Fox, B.W.: Cancer Chemother. Pharmacol.|19, 11-15 (1987), No information
Genetic toxicity in vitro, IUC4#188/Ch.5.5
Carls N. and R.H. Schiestl: Mut. Res. 320, 293-303, (1994)
Method: other: according to Schiestl (1989)
OECD (1997). Screening Information Data Set SIDS for High|Production Volume Chemicals|http://www.chem.unep.ch/irptc/sids/volume4/part1/dinitrotolu|ee/sids_rpt.html.
Ellington JJ. (2003) J Chem Eng Data. 44: 1414-1418|Hoffman CM (2003) Isobutyl Isobutyrate - Water Solubility. Final Report # 1727-WS, Eastman Kodak Company, Rochester, NY.
Beilstein Handbook, Registry Number: 605574, Last Update:|2002.10.21
Alexander M, Lustigman BK (1966) Effect of Chemical|Structure on Microbial Degradation of Substituted Benzenes.|J Agr Food Chem 14 (4): 410 - 413
Method: other: Test on biodegradation in soil
Tice, R.R., Donner, M, Udumudi, A., Vasquez, M.: In vitro|chromosomal aberration study in Chinese hamster ovary (CHO)|cells. Integrated Laboratory System, Durham, N.C., Project|No. A083-002; Contract No. DAAD05-91-C-00018; 29 August|1997; submitted to U.S. Army Center for Health Promotion and|Preventive Medicine, Aberdeen Proving Ground, MD
Weaver, E.V. Oral Reproductive/Developmental Toxicity|Screening Test in Rats with Ammonium Persulfate in Feed. |Covance Laboratories, Inc. Vienna, VA, USA. Covance Study|Number 7463-101, FMC Study Number I2003-2337. Final Report,|2004.
Prehled Prumyslove Toxikol Org Latky, pg. 86 (1986), as|cited in RTECS.
Rudzki, E. and Kleniewska, D. (1971), Kontaktallergie auf|einige Lokaltherapeutika und Konservierungsmittel,|Dermatologica 143,|36-42
Method: other: Magnusson, B. et al.: Routine patch testing IV, Acta derm.-vener. 48: 110-114 1968
Dunn, B.J. (1978) Guinea Pig Skin Hypersensitization Test, Toluene|diamine, Allied Chemical Corporation, Report No.MA-12-77-03,|18.9.1978.
Dow Corning Corporation Internal Report Number|1982-I0065-4122-06
BASF AG, Analytical Department, unpublished data |(J.Nr.: 122653/01, 1988)
Method: other (calculated): AOPWIN® ver. 1.92
Repeated dose toxicity: dermal, IUC4#107/Ch.5.4
Moreno (1975), unpublished report to RIFM, as quoted in|Opdyke DLJ (1976). Fd. cosmet. Toxicol., 14, 745-746.
Garner RC, Nutman C (1977) Testing of some Azo-Dyes and|their reduction products for Mutagenicity using Salmonella|TA1538. Mut Res 44: 9-19
Method: other: according to Ames et al., Mutat. Res. 31, 347 (1975), pos. control: acetylaminofluorene
Huntingdon Life Sciences Ltd. (2003b). Acute Toxicity to|Rainbow Trout (Semi-static exposure conditions). Project ID|CSS 032. Huntingdon Life Sciences Ltd., Cambridgeshire,|England.
Ito, N. et al.: Carcinogenesis 9 (3), 387-394 (1988);|cited in: RIFM database, location no. 9321
Weinstein, D. et al.: Mutat. Res. 46 (4), 297-304 (1977);|cited in: RIFM database, location no. 7197
Mobil International (1977). Cannon L. Acute toxicity of MCTR|191-77: Acute inhalation toxicity. Cannon Laboratories Inc.,|Edison, NJ, Report No. 7E-6995, Mobil internal report|(unpublished report).
Schering AG. 1995. ZK 24.942. Acute Toxicity to Daphnia magna. Study conducted by Huntingdon Research Center (HRC), Huntingdon, England, 07 Jan. 1994. Schering Report No. IC 1/95. 04.12.1995.
Hoechst AG (1980) Acute Fish Toxicity of|1,2-dichloro-4-nitro-benzene. Unpublished Internal Study|531/80
Dambly C, Toman Z, Radman M (1981) Zorotest. Prog Mut Res 1:|219-223
BASF AG (1991). Department of Physical Chemistry, vapour pressure, Unpublished Report, Report No. BRU 91.485, 22 November 1991.
Escherichia coli AB1157/JC5547, AB1157/JC2921, AB1157/JC2926, AB1157/JC5519, Bacillus subtilis H17/M45, HLL3g/HJ-15
EPA (2007). BIOWIN v.4.10. Estimation Programs Interface for Microsoft Windows (EPI Suite version 3.20, U.S. Environmental Protection Agency, Office of Pollution Prevention and Toxics, Washington, D.C.)
Putnam and Morris. 1991. Chromosome Aberrations in Chinese|Hamster Ovary (CHO) Cells. Microbiological Associates, Inc.|Laboratory Study Number: TA039.337100
Method: other: Standversuch nach Zahn-Wellens, DIN 38212 Teil 25 Test [Conditions according to Zahn-Wellens, DIN 38212 Part 25]
Monsanto Co (1984a) A Two Generation Reproduction Study of|p-Nitro-chloro-benzene in rats. Project No. 80-2513|(BD-80-472), Final Report, Contractor: Bio/dynamics Inc.,|report submitted to: Monsanto Co., Date: April 19, 1984,|EPA-OTS0557087 and EPA-OTS0526382
Method: other: according to OECD Guide-line 416, see also freetext ME
Reported in Du Pont, Haskell Laboratory, Internal DMAC|Review, Oct. 1988 from Katosova L.D. and G.I. Pavlenko|(1985). Mutat. Res., 147:301-302.
Goncharova, Kuzhir, Levina (1984): Vestsi Akad. Navuk BSSR,|Ser. Biyal. Navuk, 47-50
Salmonella typhimurium TA 100, TA 1535, TA1537, TA 1538
Method: other: in compliance with Ames B.K. et al., Mut. Res. 31, 347-364 (1975)
mice implanted with Salmonella Typhimurium and Saccharomyces cerevisiae
Cameron TP. Short Term Test Program sponsored by the|devision of cancer etiology, National Cancer Institute. |Cited in CCRIS, Chemical Cancer Research Information|System (1991). Cited in: ECB IUCLID 2000.
Kirk-Othmer (1996). Encyclopedia of Chemical Technology,|Fourth Edition, Vol. 20, John Wiley & Sons Inc., New York,|697-720.
Method: other (calculated): with TSAR program (Oxford Molecular)
Mirsalis JC (1982). Session III: DNA damage and repair. Use|of an in vivo DNA repair assay as an indicator of genotoxic|exposure. Banburry Report 12, 83-98.
Dowden,B.F., Bennett,H.J., JWPCF 37(9), 1308-1316, 1965, No information
Sternad W, Kempter B, Wisst S, Trick I, and Trösch W (1995).|Microbial purification of waste water from varnish|processes with waterborne paints. Third International|Symposium on Biochemical Engineering 6-8, 129-131.
Coquet PH, Durand G, Laillier J, Plazonnet B (1977)|Evaluation of ocular irritation in the rabbit: objective|versus subjective assessment. Toxicol Appl Oharmacol, 39,|129-139.
Ciba-Geigy Ltd., Chromosome studies in somatic cells, TK|10044, Chinese hamster, No. of experiment: 764028,|27.8.1981.
Genetic toxicity in vivo, IUC4#78/Ch.5.6
Acute toxicity: inhalation, IUC4#110/Ch.5.1.2
American Public Health Association. 1971. Standard Methods|for the Examination of Water and Wastewater. 1971. 13th|Edi., New York, NY)
Wallen, J.E., Greer, W.C., Lasater, R. (1957). Toxicity to|Gambusia affinis of certain pure chemicals in turbid waters.|Sewage. Ind. Wastes 29(6):695-711.
Monsanto report ES-78-SS28 as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
RBM study report no. 950100 (1996).|Istituto di Recerche Biomediche, Via Ribes 1, 10010|Colleretto Giacosa, Italy||Sponsor (and substance provided by) Industrie Chimche|Caffaro.
Rom WN, 1992. Environmental and Occupational Mediceine. 2nd|Edition. Little, Brown and Co., Boston, MA.
Ishidate, M. et al.: GANN Monograph Canc. Res. 27, 95-108|(1981), No information
Hansch C and Leo AJ (1985). MEDCHEM Project. Issue No. 26.|Claremont, CA: Pomona College.
Method: other: 1 rat /dose, single application of undiluted substance, exposure time: 24 hrs, post exposure observation time: 14 d
Huls (1992) Determination of the effects of|DYNASYLAN IBTEO on the growth of terrestrial plants|(Terrestrial plants growth test following OECD Test|guideline 208). Final Report PF 004. Degussa AG-US-IT-Nr.:|92-0235-DGO 06/05/92
Levan A and Tjio JH (1948): Induction of Chromosome|Fragmentation by Phenols. Hereditas XXXIV 32, 453-484
Gething, P.A. (1991). Potash facts. International Potash|Institute (IPI), Basel.
Reichmuth, C. Noack, S. 1983. [Environmental effects of the|fumigation of commodities.] Technol. Z. Getreide Mehl|Backwaren, 37:139-144 (in German).
Method: other: 10 rats/sex/group, reproduct. system evaluation: vaginal cytology, sperm morphology, necropsy body and reproductive tissue weights, sperematozoal data, spermatogenesis, oestrous cycle length, percent of cycle spent in various
Method: other: sperm morphology assay according Wyrobek and Bruce, 1975
Repeated dose toxicity: oral, IUC4#41/Ch.5.4
Sisti R. (2001); 2-nitroaniline preliminary oral|teratogenicity study in rats. RTC Study No 8364 -- Not|published
Method: other: preliminary study before OECD 422. Examination as in OECD 414
Khudoley VV, Mizgireuv I, Pliss GB (1987) The study of|mutagenic activity of carcinogens and other chemical agents|with Salmonella typhimurium assay: Testing of 126 compounds.|Arch Geschwulstforsch 57: 453 - 462
Method: other: no details given, see method
Sarrif AM. 1984 Du Pont de Nemours & Co, Personal|communication cited in Heck HD, Tyl RW. (1985) Regul Toxicol|Pharmacol 5(3), 294-313
Repeated dose toxicity: oral, IUC4#42/Ch.5.4
Bringmann, G. and R. Kuehn. 1980. Determination of the|biological effect of water pollutants on protozoa. Part II.|Bacteriovorous ciliates. Z. Wasser Abwasser Forsch.,13:|25-31.
Shah M, Lewis M and Gawkodger DJ (1996) Contact allergy in|patients with oral symptoms: a study of 47 patients.|American Journal of Contact Dermatitis 7: 146-151
BASF AG, Experimental Toxicology and Ecology,|3-Methyl-2-buten-1-al: Determination of the Biodegradability|in the CO2-Headspace Test, unpublished study, 00/0680/27/1,|16 Sept. 2002
Method: other: ISO 14593: CO2-Headspace Test
BUA (1989) GDCh-Advisory Committee on Existing Chemicals of|Environmental Relevance (BUA) Report 41, Nitrotoluenes. VCH,|Weinheim
Toxicity to microorganisms, IUC4#230/Ch.4.4
Method: other: EC directive 92/69, C.7 and OECD Guide-line 111
Izmerov NF at al (1982). Toxicometric parameters of|industrial toxic chemicals under single exposure.|UNEP-IRPTC, Centre of International Projects, GKNT, Moscow.|as cited in: Dura G et al. (1985): Prediction of Toxicity|Using Quantitative Structure-Activity Relationships. Arch|Toxicol, Suppl 8, 481-487
Kawai A., Goto S., Matsumoto Y., Matsushita H. 1987,|Mutagenicity of aliphatic and aromatic nitro compounds. Jpn.|J. Ind. Health 29(1), 34-55
Basic Acrylic Monomer Manufacturers. C. A. Staples,|Assessment Technologies, Inc. An Assessment of|Environmental Data for Acrylic Acid and Several Acrylate|Monomers. Fairfax, VA. 1991.
Florin, I. et al. (1980) Toxicology, 15, 219-232.
Method: other: OECD Guideline 421, see also freetext ME
Method: other: similar to OECD guideline 403, inhalation hazard test
Sturm (1908) Dissertation Wuerzburg: cited in Flury F and|Zernik F (1931) Schaedliche Gase: Dämpfe, Nebel, Rauch- und|Staubarten: 427, Berlin
Goldmann PJ (1972) Allergene und Hautkrankheiten in der|werksärztlichen Praxis eines chemischen Industriebetriebes.|Arbeitsmed Sozialmed Arbeitshyg 7: 98-100
Monsanto (1984) Unpublished study MO-92-9043 (ES-81-SS-36)
Hempel-Jorgensen, A., Hudnell, H.K., Kjaergaard, S.K., and|Molhave, L. 1999. Time Course of Sensory Eye Irritation in|Humans Exposed to n-Butanol and 1-Octene. Arch. Environ.|Health 54(2), 86-94.
National Toxicology Program (NTP) (1992) Technical Report on the Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) NIH Publication No. 91-2858 Technical report TR403.
Heck et al., 1989, An evaluation of food flavoring ingredients in a genetic toxicity screening battery, Toxicologist 9, 257-?
1,2-Benzenedicarboxylic acid, di-C6-8-branched alkyl esters, C7-rich
BASF AG, department of ecology, unpublished calculation,|22.11.1999
Rapson WH, Nazar MA, Butsky VV (1980) Mutagenicity produced|by aqueous chlorination of organic compounds. Bull Environ|Contam Toxicol 24: 590-596
Sax, N.I. Dangerous Properties of Industial Matrerials. 6th|ed. New York, NY: Van Nostrand Reinhlod, 1984. 2007
Inveresk Research International (1981). Isophorondiamin:|Sensitisation potential in guinea pigs, Project No. 417048.|Report No. 1987 (unpublished).
Method: other: Similar to OECD Guideline 406 (1981)
Method: other: Number of animals: no data, no further informations
Microbiological Associates Inc., CHO/HGPRT Mutation Assay.|Study No. T9145.332, July 18 (1990) (At the request of|Synthetic Organic Chemical Manufacturers Association Inc.).|and Batt, K.J., Healy, C.E., Kniess, J.J., Putnam, D.L.,|Jacobson-Kram, D., Weiner, M.L., and Fletcher, M.L. (1992).|Genotoxicity testing of tributyl phosphate, 23rd Scientific|Meeting of the Environmental Mutagen Society, March 15-19,|1992.
Bringmann G. et al (1977), Z. Wasser Abwasser Forsch.,|10(5), 161-66.
Method: other: according to Heil, J. et al., Anal. Biochem. 187, 314-317 (1990), and Environ. Mol. Mutagen. 17, 20-26 (1991), and Heil, J. and Reifferscheid, G., Carcinogenesis 13, 2389-2394 (1992)
Taylor, Amador. (1988): Appl. Environ. Microbiol. 54,|2342-2344| terephthalic acid and its biological half-life.|Yakugaku Zasshi 86 963-967 [Chem Abstr 66 9665 1967]
Johnson, A.G., Williams, T.D., Arnold, C.R. (1977); Chlorine|induced mortality of eggs and larvae of spotted sea trout|(Cynoscion nebulosus); Trans. Am. Fish. Soc., 106, 466-469.
Klecak G (1985). The Freund's complete adjuvant test and the|Open Epicutaneous Test, Curr. Probl. Derm. 14, 152-171,|Karger, Basel
CERI. (2005) Measurement of vapour pressure of p-toluic acid. Unpublished data.
Method: other: Bacterial forward mutation assay
BASF AG, 1989, Department of Toxicology, Golden Orfe|(Leuciscus idus L., golden variety) - Report on the study of|the acute toxicity, unpublished report 10F0606/885329, 10|June 1989.
Arthur,J.W. et al., Bull. Environ. Contam. Toxicol.|38(2),324-331, (1987)
Method: E07-04:APHA(1980) "Standard methods for the examination of water and waste water"
Repeated dose toxicity: dermal, IUC4#30/Ch.5.4
Kurume Research Laboratories, Chemicals Inspection & Testing|Institute, Japan, April 1992.Test on biodegradability of|HFC-32 by microorganisms (closed bottle method)
Foti C, Bonamonte D, Mascolo G, Tiravante G, Rigani L and|Angeline G (2001) Aminoethylethanolamine: a new allergen in|cosmetics? Contact Dermatitis 45, 129-133
Method: other: according to Wahlberg (1995)
Dupont de Nemours (1979a) Mutagenic activity in the chinese|hamster ovary assay of 1-Chloro-4-nitrobenzene. Haskel Lab.|Rep.-No. 24-80, december 1979: EPA-OTS0557127
Method: other: according OECD guideline 476, prelim. cytotox. evaluation to select conc. for mutag. assay; solvent acetone, incubation time: with TS and with S9-mix: 5 hrs, with TS without S9-mix: 18 hrs, solvent and positive control (DMN)
BRRC (1985). Various Silane and Silicone Samples, Primary|Skin Irritancy Studies (IATA Classification), Report 48-110;|September 4, 1985.
Ministry of Health, Labour and Welfare (MHLW, former MHW),|Japan (1998), Toxicity Testing Reports of Environmental|Chemicals 6, 236-246.
Method: other: OECD TG 473 and Japanese Guidelines for Screening Mutagenicity Testing of Chemicals
Dietz (1981). Unveröffentlichte Untersuchung (4852-122-136).
Method: other: HPLC and pH shift measurement
MITI, The list of the existing chemical substances tested|on biodegradability by microorganisms or bioaccumulation in|fish body by Chemicals Inspection & Testing Institute,|Japan, 2 S., (1987)
IARC (International Agency for Research on Cancer). 1986.|Monographs on the evaluation of the carcinogenic risk of|chemical to man. Geneva: World Health Organization, Methyl|Bromide. p. 187- 212, Lyon, France.
Suwa Y, Nagao M, Kosugi A, Sugimura T (1982) Sulfite|suppresses the mutagenic property of coffee. Mutat Res 102:|383-391
Salmonella typh. TA98/100/1535/1537/1538; E coli WP2uvrA
Kawachi T, Komatsu T, Kada T, Ishidate M, Sasaki M, Sugiyama|T and Tazima Y. Results of recent studies on the relevance|of various short-term screening test in Japan. in: Williams|GL et al., eds., The predictive value of short-term|screening tests in carcinogenicity evaluation, pp. 253-267,|Elsevier/Noth Holland Biomedical Press 1980.
Repeated dose toxicity: inhalation, IUC4#31/Ch.5.4
Method: other (calculated): with SRC-AOPWin v1.91, 2000
Lyon, M.F. et al.: Z. Vererbungsl. 93, 7-13 (1962);|cited in: Russell, W L.: Genetic Toxicol. Environ. Chem.|Part B, Genetic Effects Appl. Mutagenesis, 67-74 (1986)
Wijnands, W.C. & Feron, V.J., Central Institute for|Nutrition and Food Research (1969), zitiert nach Gross, P.,|Crit. Rev. Toxicol. 13, 205 (1984)
Method: other: Mirsalis et al. 1982; Env. Mutag. 4, 553; Bermudez 1982, env. Mutag. 4, 667
Graves, R.J. et al.: Mutat. Res. 320, 235-243 (1994), No information
BUA (Advisory Committee on Existing Chemicals of the|Association of German Chemists (GDCh)) (1991) BUA report No.|52 1,2-Dichloronitrobenzenes (1,2-Dichloro-3-nitrobenzene,|1,2-Dichloro-4-nitrobenzene) Weinheim, VCH|Verlagsgesellschaft
Method: other (calculated): Atkinson (1988): Environ. Toxicol. Chem. 7, 435 - 442
Suh. D. H. et al. (1983).Effect of chlorine and dioxide and|its metabolits in drinking water on|the fetal development in rat. J. Appl. Toxicol, 3, 75-79
Nonaka M., DNA repair test on food additives Environ. Mol.|Mutagen. Suppl., 14: 143, 1989 (12).
Salmonella typhimurium, TA97, TA98, TA100, TA102, TA104, TA 1535
Geiger, D.L., L.T. Brooke, and D.J. Call (eds.). 1990. Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas). Volume V. Center for Lake Superior Environmental Studies. University of Wisconsin, Superior, WI. 332p.
Method: other: USEPA methodology (actual method not specified)
BASF AG, Labor Oekologie; unveroeffentlichte Unter-suchung (Original registration No. 1901210, Date: 03.09.1990)
In this probe study, isopropyl alcohol was given at concentrations of 0.5, 1.25, 2.0 and 2.5% in the drinking water to groups of 10 rats of each sex. A group of 10 rats of each sex were given tap water alone to act as a control. The males were treated fo
CITI, Japan (1998) Report No. 21369, Chemicals Inspction and Testing Institute, unpublished data
BASF AG, department of ecology, unpublished data 94/1252,|22.02.1995
BASF Aktiengesellschaft. 2000. Determination of the Biodegradability of TZ 03497 in the Manometric Respirometry Test. Project No. 99/0605/26/1. Ludwigshafen, Germany. 17.11.00.
IBR International Bio-Research (1978a). Akute Inhalationstoxizität von 3-Isocyanatomethyl-3.5.5-trimethylcyclohexylisocyanat (IPDI) bei der Ratte. Report No. 1-4-325-77 (Veba-Chemie AG, unpublished).
BASF AG, Product Safety, Summary of results, beta-Ionon,|Range finding study in Wistar rats, administration in the|diet for 4 weeks, unpublished report, project no.|30S0449/02045, 02/449-1, 06 May 2003
Lasne, C., Gu, Z.W., Venegas, W. And I. Chouroulinkov |(1984) "The in vitro micronucelus assay for detection of|cytogenetic effects induced by mutagen-carcinogens: |Comparison with the in vitro sister-Chromatid exchange|assay. Mutat. Res. 130: 273-282.
Method: other: 0.1 ml, undiluted, 24 hrs exposure
Grant (1986). Toxicology of the eye. 3rd Ed. Charles C|Thomas. Springfield, IL
Susarla S, Masunaga S, Yonezawa Y (1996) Transformations of|Chloronitrobenzenes in Anaerobic Sediment. Chemosphere 32|(5): 967 - 977
Schubert R (1979). Toxizitaet von Organohalogenverbindungen|gegenueber Bakterien und Abbaubarkeit. Forschungsbericht|037123, Bundesminister fuer Forschung und Technologie, Bonn.
Biedermann, K.A. and Landolph, J.R. (1987) Induction of|anchorage independence in human diploid foreskin fibroblasts|by carcinogenic metal salts. Cancer Res., 47, 3815-3823.
Abraham, M.H., H.S. Chadha, G.S. Whiting, and R.C. Mitchell. 1994. Hydrogen Bonding. Part 32. An Analysis of Water-Octanol and Water-Alkane Partioning and the DlogP Parameter of Seiler. J. Pharm. Sci. 83: 1085-1100
PTB (2003). Sicherheitstechnische Kenngrößen, Volume 1:|Brennbare Flüssigkeiten und Gase, edited by Brandes E and|Möller W. Wirtschaftsverlag NW, Verlag für neue Wissenschaft|GmbH, Bremerhaven, Germany.
John-Green, J., Weisch, F., and Bus, J.S.: Teratology|32:483-487 (1985), as cited in Wolkowski-Tyl 1983b.
Method: other: in general conformance with OECD 414
Longstaff E, Robinson M, Bradbook C, Styles AZ and Purchase|IFH. Genotoxicity and carcinigenicity of fluorocarbons:|assessment by short-term in vitro tests and chronic exposure|in rats. Toxicology and Applied Pharmacology 1984 ; 72 :|15-31.
Method: other: Styles method (Br. J. Cancer 1977 ; 36 : 558-563) described in Test conditions.
Fritzenschaf H. et al.: Mut. Res. 319, 47-53, (1993)
Hepatocyte primary culture from Fisher F344 rats
Jung R, Engelhart G, Herbolt B, Jäckh R, Müller W (1992)|Collaborative study of mutagenicity with Salmonalla|typhimurium TA102. Mutat Res 278: 265-270
Method: other: modified to Maron and Ames (1983),Mutation Res. 113, 173, Levin DE (1982), Proc. Natl.Acad. Sci.(USA) 79, 7445
Monsanto Chemical Co. (1987) unpublished study Project MSL|No. 6830 5/87 (ML-86-125). Cited in letter from BGVV|06.05.1996
Hansch C. et al (1995). Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC (1995)., p. 34. cited by HSDB 21 Sep 2006
Boelhouwers EJ (2006). Determination of the N-Octanol/Water Partition Coefficient of 4,4'-Dichlorodiphenylsulfone (DCDPS) using the Shake-Flask Method. Solvay Pharmaceuticals Int. Doc. No. 7811/0054/2006.
Furth, E.E. and Thilly, W.G.: J. Food Saf. 1, 222-237|(1978);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
WSKOW, v1.41. Water Solubility Estimate from Log Kow. EPISUITE Version 3.11. Syracuse Research Corporation. Syracuse, NY.
BASF AG, Analytical Laboratory, unpublished data (330168)
Nagano, M., T. Hotoschi, M. Futatsuka (1991) Neurotoxicity in rats. Dose-effect relationship following long-term exposure. Sangyo-Igaku, 33 (2), 73-80
Repeated dose toxicity: inhalation, IUC4#29/Ch.5.4
Olivier Ph, Marzin D (1987). Study of the genotoxic|potential of 48 inorganic derivatives with the SOS|chromotest. Mutat. Res., 189, 263-269.
Lewis Sr. RJ (1996). Sax's Dangerous Properties of|Industrial Materials, 9th Edition. Van Nostrand Reinhold,|New York, 2307.
Method: other: according Kelly and Parry (1983)
Kurokawa, Y. et al.; Cancer Letters, vol. 24, 299 - 304|(1984).
Jones, J.R.E. (1940) A further study of the relation between|toxicity and solution pressure, with Polycelis nigra as test|animal. J. Exp. Biol., 17, 408-415.
Salmonella typhimurium TA98, TA100, TA1535, TA1537 and E. coli WP2uvrA
1,2,3,4-tetrahydronaphthalene (IUC4 DSN 91)
Korsak, Z, Swiercz, R. and Jedrychowski R. Effects of Acute|Combined Exposure to n-Butyl Alcohol and m-Xylene. Polish|Jor. of Occup. Med. and Environmental Health. 6(1):35-41,|1993.
Method: other: Dynamic inhalation to n-butyl alcohol or 4hr. Dynamic inhalation to a 50Vol-% mixture of 1-butanol and m-xylene.
BASF AG, Product Safety, data assessment, SRC PCKOCWIN|v1.66, 25 Oct. 2002
Method: other: calculated via PCKOCWIN v1.66
Rodgers, G. A.and Ashworth, J. (1982). Can. J. Microbiol.|28, 1093-1100.
Mobley et al. (1990). Chlorine dioxide depresses T3 uptake|and delays development of locomotor activity in young rats.|In: Jolley R.L. et al. eds. Water chlorination: chemistry,|environmental impact and health effects. Chelsea, MI: Lewis|publications, p347-358.
Lokke H (1984). Leaching of ethylene glycol and ethanol in|subsoils. Water Air Soil Pollut. 22, 373-387.
Boernick H, Eppinger P, Grischek T, and Worch E (2001).|Simulation of biological degradation of aromatic amines in|river bed sediments. Wat. Res. 35 (3), 619-624.
Monsanto Co (1977a) Toxicity Information|para-Nitro-chlorobenzene: cited in US EPA Chemical Hazard|Information Profile Draft Report 4-Chloronitrobenzene, June|13, 1983, Office of Toxic Substances, EPA, USA
Monsanto Chemical Co. (1976) unpublished study Project No.|BT-76-142. Cited from BUA Report 208, 1996
BASF AG, Physikalische Chemie, unveroeffentlichte|Untersuchung, PK 1133, 08.07.1988
S. typhimurium TA 98, TA 100, TA 1535, TA1537, E. coli WP2 uvrA
Bringmann G. & Kuehn R., Bestimmung der biologischen|Schadwirkung wassergefaehrdender Stoffe gegen Protozoen II.|Bakterienfressende Ciliaten, Z. Wasser Abwasser Forschung 1:|26-31, 1980 (93)
EA Japan (Environmental Agency, Japan) (1999b). Acute|aquatic toxicity of dicyclohexylamine on Daphnia magna. MOE|(Ministry of the Environment, Japan) unpublished data.
Cesarone C.F., Bolognesi C., Santi L. (1982), Evaluation of|damage to DNA after in vivo exposure to different classes of|chemicals: Arch. Toxicol. Suppl. 5, 355-359
Method: other: DNA damages were evaluated by the elution technique coupled with a microfluorimetric method for DNA assay
Admans G, Takahashi Y, Ban S, Kato H, Abe H, Hanai S (2001).|Artificial neural network for predicting the toxicity of|organic molecules. Bulletin of the Chemical Society of Japan|74 (12), 2451-2461.
Lick, S. et al., Unpublished report of The Dow Chemical|Company (mouse micronucleus) Study ID: K-031916-011 (1995)
Short-term toxicity to aquatic invertebrates, IUC4#49/Ch.4.2
Genetic toxicity in vitro, IUC4#154/Ch.5.5
Method: other: Bioluminescent Growth Assay
ORTEP Association. 1994. Dibutyltin Dichloride Oral (Gavage) Teratogenicity Study in the Rat. HD Project No.: 380-211. Hazelton - Deuthschland GmbH. 11.1994.
Method: other: similar to OECD Guideline 414
Short-term toxicity to aquatic invertebrates, IUC4#27/Ch.4.2
V79 Chinese Hamster Ovary cells (CCL 61)
Ott JB and Goates JR (1996). Summary of Melting and|Transition Temperatures of Pure Substances and Congruent and|Incongruent Melting Temperatures of Molecular Addition|Compounds. J. Chem. Eng. Data 41, 669-677.
Maurer, T. et al.: Contact Dermatitis 5, 1-10 (1979), No information
Zimmermann, F.K. et al., Prog. Mutat. Res. 5, 235-242 (1985)
Degussa-Huls Ag (1995) Determination of the acute effects of|DYNASYLAN ATAC On the swimming behavior of Daphnia magna (in|accordance with EG 92/69/EEC). Final Report DK 663.|Degussa-Huls AG-Nr.: 95 0219 DGO. 9/19/95
Patterson, R.M. et al. (1987): Toxic. in vitro 1, 55 - 57
Genetic toxicity in vitro, IUC4#269/Ch.5.5
Hanstveit, R. 2003. Determination of the ready biodegradability of butyltrichlorostannane in a Manometric Respiration Test. TNO Report No. V2494/01. June 2003.
Dieke, S.H. et al. (1947) J. Pharmakol. Exper. Ther., 90,|260-270.
Ullmann's Encyclopedia of Industrial Chemistry, 5th ed.|(1991), Vol. A17, p. 427
Environmental Agency, Japan (1999b) Unpublished testing|report on acute immobilization toxicity of o-chlorobenzyl|chloride to Daphnia magna, Test No.10042, conducted by Japan|Food Research Laboratories.
Nishiuchi Y (1975). Toxicity of formulated pesticides to|some fresh water organisms. XXXIII Suisan Zoshoku 23(3),|132-134.
RCC Ltd. (2005) Determination of the Freezing Point/Freezing|Range and of the Boiling Point/Boiling Range of|3-mercaptopropanoic acid methyl ester (MMP). RCC Study|Number 858400. April 28, 2005.
Vodenicharov DG, Atavina TG, Stom DI (1987) Use of Zoospore Immobilization to Evaluate the Toxicity of Phenols. Gidrobiologicheskii Zhurnal 23(1):90-94 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Boutwell, Bosch (1959) Cancer Research 19:413-427.
Wiltec (2003) Critical Point and Vapor Pressure Measurements|on Trimethoxysilane by Means of a Flow Method with Ultra-low|Residence Times. 29 July 2003. David M. VonNiederhausem and|Neil F. Giles, Wiltec Research Company, Inc.
Shugaev B (1969). Concentrations of hydrocarbons in tissues|as a measure of toxicity,. Arch. Environ. Health, Vol. 18,|pp. 878-882.
OECD Guideline 106 (Adsorption - Desorption Using a Batch Equilibrium Method)
Salmonella typhimurium TA98, TA100, TA1535, TA1537, Escherichia coli WP2uvrA/pKM101
2,2,6,6-tetramethylpiperidin-4-ol (IUC4 DSN 35)
Pyatnitzkaya LW et al. (1973): Data for substantiating the|maximum permissible concentration of beta-naphthol in the|air of industrial premises. Gig Sanit 38(10), 15-18 (in|Russian)
Grafstrom, R.C. et al.: Chem.-Biol. Interact. 86, 41-49|(1993), No information
Genetic toxicity in vitro, IUC4#318/Ch.5.5
Method: other: OECD TG 471 and 472, and Japanese Guidelines for Screening Mutagenicity Testing of Chemicals
Albert RE, Sellakumar AR, Laskin S, Kuschner, M, Nelson N,|Snyder CA (1982). Gaseous formaldehyde and hydrogen chloride|induction of nasal cancer in the rat. J. Natl. Cancer Inst.|68, 597-604.
Nat. Canc. Inst. (1978), DHEW Publ. No. (NIH) 78-1323.
Kashima, R. et al.: Fd. Chem. Toxicol. 31, 759-766 (1993), No information
General Electric (2000) Physical properties database;|January 2000.
FMC Corporation, Acute toxicity of ammonium persulfate to|bluegill (Lepomis macrochirus), Study no. I92-1246, 1993.
Du Pont (1988). DIMETHYLACETAMIDE: Properties, Uses,|Storage and Handling. Printed in U.S.A.:22.
Method: other: dermal initiation-promotion assay (see TC)
Working, P.K., Bus, J.S., and Hamm, T.E., Jr.: Toxicol Appl.|Pharmacol. 77(l):133-157 (1985).
FMC Corporation, Acute and 28-day subacute toxicity of|sodium persulfate, Study no. ICG/T-79-029, 1979.
Dow Corning Corporation (1980) Report No. |1980-I0065-1129-04
BASF AG, Analytik und Messtechnik, unpublished study, J.-No.|119046/05, 22.10.1987
Method: other: gas chromatographic determination of 3,4-dihydro-2-methoxy-2H-pyran as a function of time; test procedure according to an internal BASF standard
Hazleton, York (1991). Study to evaluate the chromosome|damaging potential of lauryl lactam by its effects on|cultured human lymphocytes using an in vitro cytogenetics|assay. Report ATO 8/HLC (unpublished)
Method: other: OECD Guideline 473 (1983)
Infracor GmbH (2002a). Determination of the hydrolysis as a|function of pH of isophorone diamine. Report No. AN-ASB 0221|(unpublished).
Method: other: Directive 92/69/EEC, C.7 and OECD Test Guideline 111 (1981)
Anthracene oil, anthracene paste,distn. lights
BASF AG, Department of Toxicology, unpublished data,|(XXV/436), 23 Aug. 1983 and Suppl. 1, 27 May 1988
Method: other: BASF-Test (orientation/pre-study)
Acute toxicity: inhalation, IUC4#62/Ch.5.1.2
Brian, D. and Hervouet, G., (1989). Determination of Acute|Toxicity of HCFC 141b to Daphnia magna. IRCHA study B.|7072, IRCHA Boite Postale No.1, 91710 Vert-le-Petit, France.
Method: other: French standard T 90 301 Jan 1983; OECD Method 202, 4 April 1984 and EEC Directive 84/449, Method C
Repeated dose toxicity: inhalation, IUC4#28/Ch.5.4
Bowman, J.H. und Schrier, L., Acute Flow-Through Toxicity of Tributyl Phosphate to Rainbow Trout Oncorhynchus mykiss.|June 21, 1990, ABC Laboratories No. 38552, Columbia, Missouri, USA. (at the request of the Synthetic Organic Chemical Manufacturers Association)
Method: other: Methods for Acute Toxicity Tests with Fish, Macroinvertebrates and Amphibians. EPA, Ecological Research Series EPA-660/3-75-009, April 1975, U.S. EPA-TSCA, 40 CFR, Part 797 (1985)
Method: other: JIS K 0102-1986-71 (Japanese Industrial Standard)
Food and Drug Research Laboratories (FDRL), Evaluation of|the safety of NMP in CD-1 Charles River mice following|90-day administration in the diet, unpublished|report, Lab. No. 5027, 21 Jan. 1977 (submitted to GAF Corp.,|ISP inventory No. 1977-006-01)
Huels AG (1993). unpublished report DDA-26. Bestimmung der|biologischen Abbaubarkeit von Malonsäurediethylester im|DOC-DIE AWAY Test. Degussa AG-Reg-Nr.: 93-0240-DGO
Method: other: Directive 79/831/EEC, Appendix V, Part C: DOC-DIE AWAY Test, Method C.4-A
BASF AG, Labor Oekologie; unveroeffentlichte Unter-suchung, (Ber.v.30.10.90) cited in IUCLID (2000)
Rodriguez J, Castro R (1942). El enlace semipolar, debe|perjudicar la reaccionabilidad química? Hydrolisis del|tricloruro y oxicloruro de fosforo. Anales de Física y|Química 38, 171-178.
Ma, T.H. et al.: Environ. Mutagen. 7, 42 (1985); abstract, No information
Buechel KH, Moretto H-H, Woditsch P (2000). Industrial|Inorganic Chemistry (2. ed). Weinheim, Wiley-VCH, 86-90.
CIBA-GEIGY, Ltd. 1989. Lack of Covalent DNA Binding of Di-n-Octyltindichloride (DOTC) in vitro. Report Nr.: PS24-02891. 2.3.1989.
Covance Laboratories (1997). Green viking. Skin irritation|study in the rabbit. Unpublished final study report No.|1516/316-1032 dated November 1997. Sponsored by Hydro|Nutrition, Oslo.
Ihara Chemical Industry Co., Ltd. (1993a) Unpublished|testing report titled "Acute oral toxicity study of|o-chlorobenzyl chloride in albino rats.", Study No.|WIL-211001, conducted by WIL Reserch Laboratories, Inc.
Method: T03-03:EPA guidelines for registering Industrial Chemicals in the U.S., Pesticide Assessment Guidelines, Subdivision F, Section 81-1, TSCA Health effects Test Guidelines, 40 CFR798.1175
EG&G Bionomics (1977) Wareham, Mass. BW-78-1-005
Budavari, S. (ed.): The Merck Index - An Encyclopedia of|Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ,|Merck and Co., Inc., No. 1676 and 2111 (2001)
Appearance/physical state/colour, IUC4#13/Ch.1.1.1
Engler R (1974). Loesliche Silikate, Woellner-Werke, 1-15;|offprint of a series of publications in Seifen, Oele, Fette,|Wachse 7, 8, 11, and 12 (1974), pages 165, 207, 269, and|298, respectively.
Bächtold H (1973): Toxicity report, Internal Communication|no 4937, Oct 29, 1973. F.Hoffmann-La Roche Ltd, Basle, Dept|TKA, unpublished internal report.
United States Environmental Protection Agency. (2000).|Estimations Programs Interface (EPI) Suite™. The EPI Suite™|and the individual models included within the software are|owned and copyright protected by the U.S. Environmental|Protection Agency.
BASF (1977) Acute dermal toxicity in rabbits (77/164 acute|dermal toxicity). BASF AG, Department of Toxicology,|16.08.1977 (unpublished data)
Method: other: in accordance with test guidelines of the US Department of Transportation (Fed.Reg. Paragraph 173.343)
Tatsuo Yamashita et al. (1974). In vivo chromosomal|aberration test of glucono-delta-lactone and sodium|gluconate with mouse bone marrow cells. Central Research|Laboratory, Fujisawa Pharmaceutical Co., Ltd.
Sanders J.G. and al., 1981, Effects of copper, chlorine and|thermal addition on the species composition of marine|phytoplankton J. Exp.Mar.Biol.Ecol., 49(1), 81-102
Salmonella typhimurium TA100, TA1535,|TA98, TA1537, TA1538
CIBA-GEIGY, Ltd. 1973. Acute Inhalation Toxicity of TK-10777 in the Rat. Project No.: Siss 2841. 10.07.1973.
Dunkel, V. et al.: Environ. Mutagen. 7 (Suppl. 5), 1-248|(1985)
THOR database Pomona 89, MedChem Software 1989. Daylight|Chemical Information Systems, Claremont, CA 91711, USA
Salmonella typhimurium TA98, TA100, TA1535, TA1537, and TA1538
ATOFINA (2001) Methyl ethyl ketone peroxide in phthalate|plasticizer: Algal growth inhbition. Report|01/SAEk/0537/DC. Unpublished study.
Oberly TJ, Bewsey BJ, Probst GS (1983) An evaluation of the|L5178Y TK+/- mouse lymphoma forward mutation assay unsing 42|chemicals. Environ Mutag 5: 417
Method: other: according Oberly et al., 1982, J.Toxicol. Environm. Health 9, 367
WIL Research Laboratories. 1996. Primary Eye-Irritation Study of Di-n-butyl-oxo-stannane in Albino Rabbits. Study conducted for ATOFINA Chemicals, Inc. Report ID: WIL-160059.
Method: other (calculated): Estimated value with KOWWIN v. 1.67
Ramadevi, G. and Ritter, P. (1997), "Micronucleus|cytogenetic assay in mice", Microbiological Associates Inc.,|Laboratory Study Number G96CJ23.122
Reust H (1980). Biological elimination, acute fish toxicity|and sewage sludge bacteria toxicity of TINOPAL DMS Pur|extra.|Summary data sheet, 12 Aug 1980, unpublished.
Biodegradation in water and sediment: simulation tests, IUC4#4/Ch.3.5
mouse lymphona cell (L5178Y), TK+- heterozygote
Monsanto Material Safety Data Sheet for ONCB and PNCB,|St. Louis, Mo., Monsanto Company, Y-83-016 (1985): cited in |Nair, R.S. et al.: Fundamental and Applied Toxicology|7, 609-614 (1986)
Method: other: 2 rabbits/sex/dose, 5 doses, single dermal application (intact skin), undiluted (warmed to make suitable for dosing), no further information, exposure time: 24 hrs, post exp.observation time: 14 d
Degussa AG, Ammonium-Persulfat (APS); Prüfung auf|sensibilisierende Eigenschaften an der Haut des|Meerschweinchens (Optimierungs-Test), Study no. 85-0014-DKT,|1985.
Method: other: ear: 11 exposures of 1% TS in 95% ethanol; 12 exposures of 5% TS in pure ethanol; abdomen: 12 exposures of 5% TS in 95% ethanol, bandaged
safety data sheet Bayer AG, Leverkusen, 07.01.92
Heath, A.G. (1978): Influence of chlorine form and ambient|temperature on the toxicity of intermittent chlorination to|freshwater fish. In: Jolley, R.L. et al. (Eds.): Water|Chlorination Environmental Impact and Health Effects, Vol.|2, 123-133.
Nair R.S. et al., The Toxicologist 4, 67 (1984)
Method: other: 15 rats/sex/group, whole body exposure, haematology, clinical chemistry, gross and microscopic examination, statistical analysis
Hazleton Research Laboratories (1989) Test to Evaluate the|Acute|Primary Cutaneous Irritation and Corrosivity in the Rabbit;|Report No. 911358; December 14, 1989
Method: other: according to Kohn, K.W. et al., Biochemistry 15, 4629-4637 (1976) and Waldmann, P., Mutation Res. 342, 113-123 (1995)
Elison C, Lien EJ, Zinger AP, Hussain M, Tong GL, Golden M|(1971). CNS activities of lactam derivatives. J. Pharmaceut.|Sci. 60, 1058-1062
S. typhimurium strains TA98, TA100, TA1535, TA1537, TA1538
Method: other: Guidelines for Screening Mutagenicity Testing of Chemicals (Chemical Substances Control Law of Japan) and OECD Test Guideline 471
Toxicity to aquatic algae and cyanobacteria, IUC4#17/Ch.4.3
Merck Schuchardt. 1994. Safety Data Sheet. Product No. 821898. Tetraoctyltin for synthesis. Date of issue: 28.03.1994.
Huels AG (1988b). Mutagenitaetsuntersuchung von Isophoron|mit Hilfe des Salmonella typhimurium /|Mikrosomen-Mutagenitäts-Tests nach Ames. Report No. 88/45|(unpublished).
Method: other: according to Ames et al. (1975), Mutat. Res. 31, 347-364
Burleigh-Flayer, H., Bevan, C., Gardiner, T., Garman, R., Kapp, R., Neptun, D., Tyler, T. and Wright, G.
Atkinson, R.: Chem. Rev. 85:69-201 (1985), as cited in|ATSDR.
Hall LH, Kier LB, Phipps G (1984) Structure-Activity|Relationship Studies on the Toxicities of Benzene|Derivatives: I. An Additivity Model. Environ Toxicol Chem 3:|355 - 365
Carpenter, C.P. and Smyth, H.F. (1946) Chemical burns of|the rabbit cornea, Am J. Ophthalmol. 29, 1363-1372
Alarie (1981), cited in Withers R.M.J. and Shaw J.P.H., Mod.|Chlor-Alkali Technol., 4, 51-61 (1990)
Assmann N., Emmrich M., Kampf G., Kaiser M. (1997);|Genotoxic activity of important nitrobenzens and|nitroanilines in the Ames test and their structure-activity|relationship. Mutat. Res. 395(2-3), 139-144
Hüls AG (1984c). Prüfung der akuten Augen- und Schleimhautreizwirkung von Isophorondiisocyanat (IPDI). Report No. 0291 (unpublished).
Sittisuang, P. Nakakita, H., 1985. The effect of phosphine|and methyl bromide on germination of rice and corn seeds. J.|Pestic. Sci., 10:461-468.
TNO: Central Insitute for Nutrition and Food Research,|Report No. 3157, April 1970
CIBA-GEIGY, Ltd. 1981. Report on Skin Irritation in the Rabbit after Single Application of TK 11638. Project No.: 811187. 28.12.1981.
Salmonella typhimurium TA 1535, TA 1537, TA 1538
Huels AG (1993). unpublished report. AW-297. Bestimmung der|Auswirkungen von Malonsäurediethylester auf das Wachstum von|Scenedesmus subspicatus 86.81.SAG (Algenwachstumshemmtest|nach Richtlinie 88/302/EWG). Degussa AG-Reg-Nr.:|93-0236-DGO.
Strains TA 98, TA100, TA 1535, TA 1537 and TA1538
Huang Q, Liu Y, Wang L, Han S, Yang J (1996) Genotoxicity|of substituted nitrobenzuenes and the quantitative|structure-activity relationship. J Environm Sci 8: 103-109
Steinmetz, K.L. and Mirsalis, J.C.: Environ. Mutagen. 6 (3),|446 (1984); abstract;|cited in: RIFM database, location no. 23722
Bayer AG 1986d, Internal study: Toxicity to Brachidanio|rerio (1986)
BASF AG (2002). Amendment No. 1 to the report: In vitro gene|mutation test with formic acid in CHO cells (HPRT locus|assay). Unpublished study report on project No.|50M0102/024017; dated October 24, 2002.
Kurume Research Laboratories, Chemical Biotesting Center,|Chemical Inspection & Institute, Japan,February 28, 1992.|test on measurement of dissociation constant,report 80677.
Method: other (calculated): Calculated values using AOPWIN version 1.89, a subroutine of the computer program EPIWIN version 3.04
Method: other: in accordance with Hill, Ass. Food Drug Off. 18, 142, 1954
Braendle, R. & Erismann, K.M. (1973): Beeinflussung der|DNS-Synthese durch Sulfit im Wurzelmeristem der Puffbohne|(Vica faba). Experientia 29, 586-587
IIT Research Institute. 1991. Dermal Sensitization of|Isophthalic Acid in Guinea Pigs Using the Modified Buehler|Method. Study No. 1695.
CIIT (1978). Docket 22838. 104 week toxicity study in rats,|dinitrotoluene, interim report - 26 weeks, Chemical Industry|Institute of Toxicology, Research Triangle Park, USA, NTIS|OTS 205947.
Hegna IK and Clausen OG (1988). An investigation of the|bactericidal and fungicidal effects of certain disinfectants|by use of a capacity test. Ann. Inst. Pasteur/Microbiol.|139: 473 - 483.
Hoechst AG (1994): Unveröffentlichte Untersuchung OC 103-93
Guel S., Oeztuerk D., Determination of structure-toxicity|relationship of amphiprotic compounds by means of the|inhibition of the dehydrogenase activity of Pseudomonas|putida, Turk J Chem 22: 341-349, 1998
BASF AG (1963) Acute oral toxicity of choline chloride 70%|in water. Department of Toxicology, unpublished results,|Study No. XIII 9, 25.01.1963
Camarasa, G. and Alomar, A. (1978), Menthol dermatitis from|cigarettes, Contact Dermatitis 4, 169-170
Method: other: as described by Clive and Spector (1975): Mutat. Res. 31, 17-29
2-(dimethylamino)ethyl acrylate (IUC4 DSN 48)
Lindstrom HV, Bowie WC, Wallace WC, Nelson AA and Fitzhugh|OG (1969) The toxicity and metabolism of Mesidine and|Pseudocumidine in rats. J Pharmacol Exp Ther 167: 223-234
Method: other: single dose by stomach tube, 14-day observation period, calculation of LD50 with the Bliss probit method
VEBA-Chemie AG (1975). Isophorondiamin - IPD -|3-Aminomethyl-3.5.5-trimethylcyclohexylamin. Information|sheet No. 22-MD-175-1, Gelsenkirchen.
Method: other (calculated): extrapolated from test results at higher temperatures.
BASF AG, Laboratorium fur Angewandte Biologie. 1989. Prufung|auf Okotoxizitat: Hemmung der Algen-Zellvermehrung nach DIN|38412L9 (unpublished study). Journal number 01038,|15.12.1989.
Method: other: sister-chromatid exchanges (see freetext TC)
Genetic toxicity in vitro, IUC4#127/Ch.5.5
GAF Chemicals Corp., Wayne, NJ, unpublished data, HLA Study|No. 10194-0-435, Hazleton Laboratories America, Kensington,|Maryland, USA, June 23, 1988
Method: other: CHO/HGPRT forward mutation assay
Thioesters Association (2006) Personal Communication
Huang Q, Wang L, Han S (1995) The genotoxicity of|substituted |nitrobenzenes and the quantitative structure-activity|relationship studies. Chemosphere 30: 915 - 923
Bailey HC, Spanggord RJ (1984) The Relationship between the|toxicity and structure of nitroaromatic chemicals. Aquatic|Toxicol Sixth symposium: 98 - 107
FMC Corp. data (1976), EPA OTS 86860000114 cited in BIBRA|Toxicity Profile (1991)
Long-term toxicity to aquatic invertebrates, IUC4#90/Ch.4.5.2
Bikbulatov, N.T. (1976): Gig. Tr. Zabol. Neft Neftekhim |Prom-st, 118 - 121|cited in: Shell International (1988): Review of toxicology|Ionol CP (butylated hydroxytoluene, BHT)
Zeiger E, Haworth S, Mortelmans K, Speck W. (1985)|Mutagenicity testing of di(2-ethylhexyl)phthalate and|related chemicals in Salmonella. Environ Mutagen 7, |213-232
Method: other: 10 rats/dose, 6 doses, subst.(solved in polyethylene glycol 400) appl. on the shaved back for 24 hours, covered by alu and a plaster, then rinsed with water and soap, post exposure observ.-time: 14 d
BASF AG, 1988, Department of Product Safety, Laboratory of|Toxicology, Acute toxicity of choline chloride to the|Golden Orfe, unpublished data, 10F0003/885093, 20 Oct 1988
Huels AG (1989). Verteilungskoeffizient n-Oktanol-Wasser|(Pow-Wert) fuer "Altstoffe". Letter 3610-15/ka dated|10.01.89 (unpublished).
Steinhagen, W.H. and Barrow, C.S.: Toxicol. Appl.|Pharmacol.72, 495-503 (1984)
Method: other: according to Alarie, Y.: Arch. Environ. Health 13, 433-449 (1966)
Lang P, Ma X-F, Lu G, Wang Y, Bian Y (1996) QSAR for the|Acute Toxicity of Nitroaromatics to the Carp (Cyprinus|carpio). Chemosphere 32 (8): 1547 - 1552
Short-term toxicity to fish, IUC4#19/Ch.4.1
RTECS (1992) On line Access January 1992
Tsutsumi S, Yamaguchi T, Komatsu S and Tamura S (1968). On|the teratogenic effects of vitamin A-like substances,|Congen. Anomal. Res. Assoc. Jap. Proc. 9, 27 (abstract)
Chiu CW, Lee LH, Wang CY, Bryan GT (1978) Mutagenicity of|some commercially available nitro compounds for Salmonella|typhimurium. Mutation Res 58: 11-22
Method: other: according to Ames et al., Proc.Natl. Acad. Sci (USA), vol.70, p. 782 (1973) see also freetext Method
Industrial Biology Laboratories Inc, Shelanski MV (1963 b)|Modified Schwartz patch test. Study report Project No.|SH-63-15. Unpublished study of Monsanto Chemical Co
Salmonella typhimurium TA-1535, TA-1537, TA-1538, TA-98, and|TA-100
Method: other: micronucleus assay in mouse bone marrow, see freetext TC
The Merck Index, 13th edition, Merck & Co., Inc. 2006.
Lachapelle JM and Lachapelle-Ketelaer MJ (1979). Cross-sensitivity between isophorone diamine (IPD) and isophorone diisocyanate (IPDI). Contact Dermatitis 5, 55.
Acute toxicity: inhalation, IUC4#59/Ch.5.1.2
Tucker, J.D., Xu, J., Stewart, J., Ong, T., 1985.|Development of a method to detect volatile genotoxins using|sister chromatid exchanges. Environ Mutagenesis 7:48-49|(Abstract).
Method: other: calculated: WSKOW v. 1.40 in EPIWIN suite (assuming no hydrolysis)
Geiger, D.L., Poirier, S.H., Brooke, L.T. and Call., D.J.|(1986) Acute Toxicities of Organic Chemicals to Fathead|Minnows (Pimephales promelas), Vol. 3., Center for Lake|Superior Environmental Stud., Univ. of Wisconsin-Superior,|Superior, WI I:328.
Method: other: American Public Health Association (1980). Standard Methods for the examination of water and wastewater (15th ed.)
BASF (1981) Short-term respiration inhibition test with BASF|activated sludge. BASF AG, Dpt. of Ecology, 07.04.1981|(unpublished data)
Degussa AG (2002). Degussa isophorone exposure questionnaire|(unpublished).
Salmonella typhimurium strains TA 1535, TA 1538, TA 98 or TA 100.
Microbiological Associates, Inc. (1995) Y-4398:|Salmonella/Escherichia coli Preincubation Mutagenicity Assay|with a Confirmatory Assay. Laboratory Study Number|G95AD27.503001 04/17/95
Orstavik, D. and Hongslo, J.K.: Biomaterials 6, 129-132|(1985), No information
Takahashi, O., Hiraga, K. (1978): Food Cosmet. Toxicol. 16,|475 - 477
Harris JC (1990). Rate of hydrolysis. In: Lyman WJ, Reehl|WF, Rosenblatt DH. Handbook of Chemical Property Estimation|Methods. Americ. Chem. Soc., Washington, 7-4 - 7-5.
Noack Laboratorium (1989): Unpublished results (8.683)
Bayer AG (1986) Internal study (1986-01-29)|- Acute toxicity test with Brachydanio rerio
Berol Nobel AB (1990) Analytical Report, February 1990.
Yuan X, Lang P, Long F, Lu G (1994) The Relationship Between|Toxicities of Nitroaromatic Hydrocarbons to Photobacterium|phosphoreum and Other Aquatic Organisms. Jilin Daxue Ziran|Kexue Xuebao (4): 97 - 100
Jow P. and C.H. Hansch (1985): Unpublished analysis|cited in: Hansch, Leo (1985)
Method: other: Liver and Bladder Carcinogenesis Promotion Assay
Amoco Corporation (1989) A Segment II Inhalation Teratology|Study of Terephthalic Acid in Rats. Conducted by IIT|Research Institute. IITRI Study #1448
USEPA. 2000. KOWWIN. Version 1.67. Estimation Programs Interface (EPI) Suite. Version 3.11. Office of Pollution Prevention Toxics (OPPTS) and Syracuse Research Corporation.
Silver, S.D. and McGrath, F.P. (1942): Chlorine Median|lethal concentration for mice. Edgewood Arsenal, Md. U.S.|Army.
Method: other: Measured in peripheral lymphocytes cells
Yang. L.L. et al.: Carcinogenesis, 102, abstract no. 401,|(1984), No information
Vogel, E.W. and Nivard, M.J.M.: Mutagenesis 8, 57-81 (1993), No information
Genetic toxicity in vivo, IUC4#74/Ch.5.6
Friedman, L. et al.: Toxicol. Appl. Pharmacol. 48 (1 pt. 2),|A122 (1979); abstract no. 243;|cited in: RIFM database, location no. 28212
Microbiological Associates, Inc. 1990. Chromosome|Aberrations in Chinese Hamster Ovary (CHO) Cells. |Laboratory Study Number: T9410.337.
Anbar M and Neta P (1967). A Compilation of Specific|Bimolecular Rate Constants for the Reactions of Hydrated|Electrons, Hydrogen Atoms and Hydroxyl Radicals with|Inorganic and Organic Compounds in Aqueous Solution, The|International Journal of Applied Radiation and Isotopes 18,|493-523
BOD5 Method: other: APHA Standard Method
Weast, R.C. (ed.) (2000-2001). In CRC Handbook of Chemistry|and Physics. 81th edn. CRC Press Inc., Boca Raton, Florida,|p. B-144.
Kaiser KLE, Palabrica VS and Ribo JM (1987). QSAR of acute|toxicity of mono-substituted benzene derivatives to|Photobacterium phosphoreum. In: Kaier KLE (Ed.) QSAR in|Environmental Toxicology II: D. Reidel Publ. Co, Dordrecht|153-168.
Infracor GmbH, Degussa Group (2002). Determination of the|immobilisation of Daphnia magna STRAUS. Report No. DK 763|(unpublished)
CIBA-GEIGY, Ltd. 1986. Test No. 830524. Test for Non-Disjunction of Saccharomyces Cerevisiae D61.M (in vitro). 04.07.1986.
Method: other: Ames et al. (1973); Zimmerman et al. (1984)
Rohm & Haas Co. / Affiliated Medical Research, Inc.,|Princeton, N.J. (1972b). 90-Day subchronic toxicity of|isophorone in the rat, NTIS/OTS Microfiche 0205975, Doc|878212178.
Dooley, J.F. et al.: Environ. Mutagen. 7, 9 (1985); abstract, No information
Mercier, O. (1992b). Hazleton France Test to evaluate|sensitizing potential in the guinea-pig. Guinea-pig|Maximization Test. Report number: 201380,. Study conducted|for Wacker Chemie GmbH, October 19, 1992.
MHLW, Japan (2004d) Ministry of Health, Labour and Welfare: In vitro chromosomal aberration test of 4-Methylbenzoic acid in cultured chinese hamster cells. Japan Toxicity Testing Reports of Environmental Chemicals, 11, 234-239.
Method: other: OECD Test Guideline 473 and Japanese test guideline
Oldersma, H., A.O. Hanstveit, and J.M. de Wolf. Trichlorooctylstannane (MOTC, CAS# 3091-25-6): Determination of the effect on the growth of the fresh water green alga Scenedesmus subspicatus. TNO Report No. V2496/04. November 2003.
Internal DMAC Review, Oct. 1988 from Fassett D.W.,|Unpublished Eastman Kodak Co. Data (Ref. from Horn H.J.|1959).
Bertelo, C. 2001. Determining the solubility and rate of hydrolysis of organotin compounds. Unpublished company report. ATOFINA Chemicals, Inc. November 30, 2001.
Kuboyama, N. and A. Fujii. Mutagenicity of analgesics, their derivatives, and anti-inflammatory drugs with S-9 mix of several animal species; J. Nihon Univ. Sch. Dent., 34 (3), 183-195, 1992
Reported in AIDA (13/11/92)-ALSTOFF INFORMATION Date Bank|from BASF AG (1977), Ecological Laboratory-Unpublished Data.
Toxicity to microorganisms, IUC4#100/Ch.4.4
Richter D (1934) The action of inhibitors on the catechol oxidase of potatoes. Biochem. J. 28:901-908 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Toxicity to terrestrial plants, IUC4#14/Ch.4.6.2
DuPont (1995). Testing of 1,4-dichloro-2-butene in the rat bone marrow micronucleus assay by inhalation. Haskell Laboratory, Report No. 361-93 from March 30, 1995.
BASF (2002) Calculation of vapour pressure with MPBPWIN v|1.40. BASF AG, Product Safety, Regulations, Toxicology and|Ecology 19.07.2002 (unpublished data)
Method: other (calculated): MPBPWIN v.1.40, US EPA (2000), modified Grain method
Method: other: according to Smyth et al., Am. Ind. Hyg. Ass. J. 23: 95-107 (1962): no further details given
Calley, D.J., W.L. Guess, and J. Autian. 1967. Hepatotoxicity of a series of organotin esters. Journal of Pharmaceutical Sciences. 56(2):240-243.
Baker RS, Bonin AM (1981) Study of 42 Coded Compounds with|the Salmonella/Mammalian Microsome Assay. Prog Mut Res 1:|249-260
Repeated dose toxicity: oral, IUC4#38/Ch.5.4
Hazardous Substances Data Bank, print from 01/14/2002
Chemicals Evaluation and Research Institute (2004). Boiling|Point of 4-ethylmorpholine. Report Number 805287.
Battersby, Wilson (1989): Appl. Environ. Microbiol. 55,|433-439
Method: other: Biodegradation under methanogenic conditions
Starmer, G.A. S. McLean, J. Thomas. Analgesic potency and acute toxicity of substituted anilides and benzamides, Tox. Appl. Pharm. 19, 20-28, 1971
Emmett, E.A., and Suskind, R.R. (1973) Allergic contact sensitization to the toluic acids. The Journal of Investigative Dermatology, 61(5), 282-285.
Ciba (1993). Internal report. Analytics Additives. June 24,|1993
Mueller et al.; Health Physics 53, 667-671 (1987)
Junke I. et al (1978), Z. F. Wasser- und Abwasser-Forschung,|11(5), 161-64.
Short-term toxicity to aquatic invertebrates.002
Horvath, Ari L.; Boiling points of halogenated organic|compounds, Chemosphere 44 (2001) 897-905
Method: P03-03:collection from different sources
MacPhee C and Ruelle R,1969, Lethal effects of 1888|chemicals upon four species of fish from western North|America, University of Idaho, Coll. of Forestry-Wildlife and|Range Science, Moscow (Idaho), Bulletin No 3, 1-112
ECT Oekotoxikologie GmbH (2007a). Formic acid, BCFWIN|(v.2.17) calculation. ECT Oekotoxikologie GmbH,|Flörsheim/Main, Germany, 01 Aug 2007, (unpublished).
Bioaccumulation: aquatic / sediment, IUC4#0/Ch.3.7
Salmonella typhimurium strains TA98, TA100, TA1535, TA1537 and TA15|38
Heidelberger, C., Freeman, A.E., Pienta, R.J., Sivak, A.,|Bertram, J.S., Casto, B.C., Dunkel, V.C., Francis, M.W.,|Kakunaga, T., Little, J.B. and Schechtman, L.M. (1983),|"Cell transformation by chemical agents-a review and|analysis of the literature: A report of the U.S. EPA|Gene-Tox Program", Mutation Research 114, pp. 283-385
Bringmann G, Kuehn R, and Winter A (1981). Veraenderung der|Toxizitaet von Aminen in Zweistoff-Kombinationen.|Testorganismus: Scenedesmus subspicatus. Z. Wasser- Abwasser|Forsch. 14(3), 75-79.
Method: other: cell multiplication inhibition test according to Bringmann and Kuehn (1980). Water Res. 14, 231-241.
Method: other: in general conformance with OECD Guideline 453
Smyth H.F. et al.: A.M.A. Archiv. Industr. Hyg. Occup. Med.|4, 119-122, (1951)
Acute toxicity: inhalation, IUC4#55/Ch.5.1.2
Litton Bionetics Inc. (1979). Mutagenicity evaluation of|C-63, aqueous sodium formate (residue stream) in the mouse|lymphoma forward mutation assay. Unpublished study report|No. 20989, dated April 1979. Sponsored by Celanese Corp.,|New York, NY.
Blevins, R.D.: Envir. Mutagen. 9, 17 (1987) cited in BIBRA Toxicity Profile (1991) and Pancorba, O.C. et al.: Arch. Envir. Hyg. ASS. J. 41, 220 (1980) cited in BIBRA Toxicity Profile (1991)
Del Vaglio G (1992) FAT 65'023/N: Water solubility.|CIBA-GEIGY Ltd., CH-4002 Basel (Switzerland)
Yin, M. et al.: Environ. Mol. Mutagen. 14, suppl. 15,|225-226 (1989); abstract no. 655, No information
Genetic toxicity in vitro, IUC4#144/Ch.5.5
Cultured Primary Syrian hamster embryo cells
Grant, W.M. (1986). Toxicology of the eye. 3rd ed., 424-425,|Springfield, IL: Charles C. Thomas Publisher.
Escherichia coli W 3110 (pol A+), P 3478 (pol A-)
BASF AG, Department Ecology, unpublished data on the|toxicity of Glyezin A to the algae Scenedesmus subspicatus|in the growth inhibition test, Report No.: 2/1009/88, 15.|Sept. 1989
Method: other: comparable to DIN 38412, part 9
Method: other: CIBA-GEIGY Internal Method A-11
Booth G (2003). Nitro Compounds, Aromatic. In: Ullmann´s|Encyclopedia of Industrial Chemistry (6th ed, electronic|version). Wiley-VCH Verlag GmbH & Co.KGaA., Weinheim.
BASF (1981) Respirometric test (mucochloric acid purified|technical grade). BASF AG, Dpt. of Ecology, 04.08.1981|(unpublished data; Reprint 18.07.2002)
Method: other: Guideline for the 28-Day Repeated Dose Toxicity Test in Mammalian Species(Chemical Substances Control Law of Japan)
Infracor GmbH, Degussa Group (2002). Determination of the|acute toxicity for the fish cyprinus carpio. Report No. FK|1434 (unpublished)
Method: other (measured): measured at the Japanese Chemicals Inspection and Testing Institute
Wacker Chemie (1987) Pharma Research Toxicology and |Pathology; Hoechst Aktiengesellschsft (1987) |Silan HMN-Study of the Mutagenic Potential in |Strains of Salmonella typhimurium (Ames Test)|and Escherichia coli; Study No. 87.0448.
Method: other: As described by Ames, B. N. et al., Proc. Nat. Acad. Sci. (USA) 70, 2281-2285 (1973); Ames, B. N. et al., Mutat. Res. 31, 347-364 (1975); Green, M.H.L. and W.J. Muriel, Mutat. Res. 38, 3-32 (1976)OECD Guide-line 481
CIT (2006) Acute Dermal Irritation in Rabbits. Study number|26959 TAL. Study sponsor: L'Oreal.
# changed genes ((Fold change>1.25 OR Fold change<0.8) AND P-value<0.05)
BASF AG (1985). Department of Ecology, report J.No.|18365/85, study No. 1277, 22 Nov 1985, unpublished.
Method: other: OECD Guide-line 209, ISO 8192 B
Pollard, I. and Smallshaw, J.: J. Develop. Physiol. 10,|271-281 (1988)
BASF AG, department of ecology; unpublished report|(88/0548), 19.12.1988
Method: other: Pseudomonas-Zellvermehrungs-Hemmtest, DIN 38412 Teil 8, zum Gelbdruck verabschiedet, Bestimmung der Hemmwirkung von Wasserinhaltsstoffen auf Bakterien
LISEC (1999). Alga, growth inhibition test effect of|5-Ethylidene-2-Norbornene on the growth Selenastrum|capricornutum. Report No. WE-06-236. LISEC, Craenevenne,|Genk., Belgium.
Drake, J.C. 1973. Geigy Pharamceuticals. Primary Skin Irritation Test in Albino Rabbits with Compound TK 11339. 30.1.1973.
Method: other: U.S. Federal Hazardous Substances Labelling Act, Section 191.11
MHLW, Japan (2004b) Ministry of Health, Labour and Welfare: Twenty-eight-day repeat dose oral toxicity test of 4-Methylbenzoic acid in rats. Japan Toxicity Testing Reports of Environmental Chemicals, 11, 204-215.
Method: other: Guideline for the 28-Day Repeated Dose Toxicity Test in Mammalian Species(Chemical Substabce Control Law of Japan)
Design Institute for Physical Property Research (DIPPR) |(2003) Private communication.
Christina Z. Thompson, Leo E. Hill, Janet K. Epp and Gregory|S. Probst (1983) The Induction of Bacterial Mutation and|Hepatocyte Unscheduled DNA Synthesis by Monosubstituted|Anilines, Environmental Mutagenesis 5, 803-811
Method: other: Gradient plate test (McMahon, et al., 1979, Cancer Research, 39, 682-693)
Khangarot, B.S. (1991) Toxicity of metals to a freshwater|tubificid worm, Tubifex tubifex (Muller). Bull. Env. Contam.|Toxicol., 46, 906-912.
Hüls AG (1993c). Bestimmung der Auswirkungen von Vestamin|IPD auf die Reproduktionsrate von Daphnia magna. Report No.|DL-149 (unpublished).
Method: other: OECD Guide-line 202, part 2 (1984)
Schering AG. 1989. Evaluation of gene mutations in mammalian cells in culture: HGPRT-test with V79 cells. Report No. IC 16/89. March 21, 1989.
Last J (1989) Effects of inhaled acids on lung biochemistry.|Environ Health Perspect 79: 115-119
Method: other: specific parameters of lung response
Ato-Chimie (1982) Salmonella mutagenicity test of amino|undecanoic acid. IFRB Report no. 204204, 26 may 1982.
Method: other: equivalent to OECD Guide-line 471
National Institute of Environmental Research(NIER), Korea(2001), Test of Acetanilide Boiling point(tested by LGCI )
Krijgsheld K.R., van der Gen A. (1986), "Assessment of the|impact of emmission of certain organochlorine compounds on|the aquatic environment. Part II - Allyl chloride, 1,3- and|2,3-dichloropropene", Chemosphere, 15(7), 861-80.
Valencia, R. et al.: Environ. Mol. Mutagen. 14, 238-244|(1989), No information
Kuehn, R. and Pattard, M., Results of the harmful effects of|water pollutants to green algae (Scenedesmus subspicatus) in|the cell multiplication inhibition test, Water Research 24|(1), 31-38 (1990)
Method: other: DIN-Standard 38412 L9 (Algae, Cell multiplication inhibition test)
Schlee, D. (1992): Sulphite-induced changes of sulphur|metabolism in the lichen alga Trexouxia sp. New Phytol.|122(2), 307-311
Method: other: The concept NEN reports 6501 or 6502 (Dutch Standard Organization (1980) and Canton et al. (1975))
Salem, H. and Cullumbine H.: Toxicol. Appl. Pharmacol. 2,|183-187 (1960)
Method: other: according to Salem, H.: Dissertation, University of Toronto, Canada (1958)
BASF AG (1980). unpublished data, report No. TUU/W 3 78/306, April 1980
Method: other: Respirometry test with different test substance concentrations using a Sapromat
Patterson KM, Hirsch MP. 1995. An Acute Aquatic Effects Test with the Daphnid Daphnia magna. Study #EN-431-900945-1, Eastman Kodak Company, Health and Environment Laboratories, Rochester, NY. August 3, 1995.
Method: other: OECD 202 and EEC/Annex V C.2
Jiang, X.Z., White, R., and Morgan, K.T.: Neurotoxicology|6:93-104 (1985).
Bayer AG (1985) Internal study: Acute fish toxicity test|with Leuciscus idus (1985-03-12)
Migchielsen MHJ (2002): Acute toxicity study in Daphnia|magna with Isophytol (semi-static). NOTOX Project 349392,|NOTOX BV, 's-Hertogenbosch, The Netherlands; test performed|on behalf of F. Hoffmann-La Roche Ltd, Basel.
Bringmann G and Kuehn R (1981). Vergleich der Wirkung von|Schadstoffen auf flagelate sowie ciliate bzw. auf|holozoische bakterienfressende sowie saprozoische Protozoen.| GWF-Wasser/Abwasser 122, 308 - 313.
Method: other: Inhibition of cell reproduction acc. to Bringmann et al.
Hoechst AG, unveroeffentlichte Untersuchung 87.0392,(1987)|zitiert im Hoechst-GDS vom 14.04.(1994)
Yamada Y, Kusuhara N, Okada H (1977): Oxidation of linear|terpenes and squalene variants by Arthrobacter sp. Appl|Environ Microbiol 33(4): 771-776.
Eastman Chemical Company, Product Quality Report, 22 March 2005.
Method: other: according to Kada, Mutat.Res 16,165 (1972), Hirano, Mutat.Res. 97,339 (1982)
Lang P-Z (1996) QSAR for the acute toxicity of|nitroaromatics to the carp (Cyprinius carpio). Chemosphere|32 (8): 1547 - 1552
Powell, C.J. et al. (1986): Food Chem. Toxicol. 24, |1131 - 1143
Repeated dose toxicity: oral, IUC4#31/Ch.5.4
Jones W.H. Toxicity and Health Hazard Summary, Laboratory|of Industrial Medicine, Eastman Kodak Company, Kodak|Park.(1967)
BASF AG, Department of Toxicology, unpublished studies|(VII/310, VII/350), 21 July 1958
Rowe, Wolf; In: Patty's Ind. Hyg. Toxicol., Vol. 2C, 3rd Ed., 4028-4029 (1982)
Salmonella typhimurium (TA98, TA100, TA1535, TA1537, TA1538)
Office of Toxic Substances, US EPA (1984): Chemical Hazard|Information Profile Draft Report, Butylated Hydroxytoluene,|August 13, 1984
Genetic toxicity in vitro, IUC4#282/Ch.5.5
Morlay C, De Laat J, Dore M, Courtois Y, Houel N, Montiel A|(1992) Effect of sodium sulfite on the mutagenicity of|chlorinated drinking water. Bull Environ Contam Toxicol 49:|772-779
METI Japan (1996) Ministry of Economy, Trade and Industry (former MITI), test report conducted by Chemicals Evaluation and Research Institute (CERI, Japan) Test No. 21219K
Bringmann G and Kuehn R (1982). Ergebnisse der Schadwirkung|wassergefaehrdender Stoffe gegen Daphnia magna in einem|weiterentwickelten standardisierten Testverfahren. Z.|Wasser- Abwasser Forsch. 15 (1), 1-6.
Method: other: Immobilization test according to Bringmann G and Kuehn R (1977) Z. Wasser Abwasser Forsch. 10, 161-166
Tabak HH, Desai S and Govind R (1990). Determination of|biodegradability kinetics of RCRA compounds using|respirometry for structure-activity relationships / 44th|Purdue Industrial Waste Conference Proceedings, 405-423,|Lewis Publishers Inc., Chelsea, MI.
Method: other: Respirometric Oxygen Uptake Test
Method: other: 6 animals/group/strain tested; 3/6 sacrificed 1 day after the last exposure, 3/6 after a 14 d-recovery period; chamber atmosphere was examined in 1h-intervals
Litton Bionetics, Inc. Project No. 20989, July, 1983.
Sasaki H, Kojima M, Nakamura J, Shibasaki J (1990) Acute|toxicity and skin irritation of pyrrolidone derivates as|transdermal penetration enhancer, Chem. Pharm. Bull., 38,|2308-2310
OECD Guideline 301 A (old version) (Ready Biodegradabiltiy: Modified AFNOR Test)
Arni P (1985) Induction of various genetic effects in the|yeast Saccharomyces cerevisiae strain D7. Prog Mut Res 5:|217-224
Method: other: according Zimmermann (1975) Mutat. Res. 28, 381, see freetext ME
Verschueren K (1983). Handbook of Environmental Data on|Organic Chemicals, Second Edition. Van Nostrand Reinhold,|New York, USA, 683-685.
EPIWIN CALCULATION taking into account the zwitterion form|of the substance
Method: other: as described in "Standard Methods for the Examination of Water and Wastewater", 16th ed., USPHA, Washington, D. C., 1985
Schmitt H, Altenburger R, Jastorff B, Schüürmann G (2000)|Quantitative structure-activity analysis of the algae|toxicity of nitroaromatic compounds. Chem Res Toxicol 13:|441 - 450
Method: other: Method according to Altenburger (1990)
USEPA (2009) Estimations Programs Interface (EPI) Suite™ for|Microsoft Windows®, v4.00. United States Environmental|Protection Agency, Washington, DC, USA.
Bacillus subtilis 17A (Rec+), 45T (Rec-)
Yin, X. et al.: Zhongguo Huanjing Kexue 11, 39-43 (1991), No information
BASF AG, 1984, Department of Product Safety, Laboratory of|Ecology, Pruefbericht ueber eine Untersuchung auf|biologische Abbaubarkeit im BSB5-Test - Cholinchlorid|(German), Test No. 01606, 16 Feb. 1984
McQuaid JB, Stocker DW, and Pilling MJ (2002). Kinetics of|the reactions of OH with 3-methyl-2-cyclohexen-1-one and|3,5,5-trimethy-2-cyclohexen-1-one under simulated|atmospheric conditions. Int. J. Chem. Kinet. 34, 7-11.
Marhold, J. 1986. Prehled Prumyslove Toxikologie; Organicke|Latky. Prague, Czechoslovakia, Avecenum, 317.
Short-term toxicity to fish, IUC4#84/Ch.4.1
Biodegradation in water: screening tests, IUC4#45/Ch.3.5
Vernot et al. (1977), Acute toxicity and skin corrosion data|for some organic and inorganic compounds and aqueous|solutions: Toxicol. Appl. Pharmacol. 42, 417-423.
Boublik T, Fried V, Hala E (1973) The vapour pressures of pure substances. New York, NY, Elsevier Scientific Pub Co. 626 PP (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Ritter A (1988) FAT 65'023/L: 24-hour acute toxicity of FAT|65'023/L to daphnia magna. RCC Umweltchemie Itingen|(Switzerland)
El-Dib, M.A., O.A. Aly. Persistence of some phenylamide pesticides in the aquatic environment -III. Biological Degradation. Water Res. 10, 1055-9, 1976
Method: other: test procedure according to an internal BASF standard, comparable to OECD 105
BASF AG (1995) Department of Technical Development, report|BRU 95.208, 17 Jan 1995, unpublished.
Eye injury was recorded in a 10-grade ordinal series and was based upon the degree of corneal necrosis that results from instillation of 0.5 ml of 1% aqueous solution in the eye with results read 24 hours later. Grade 1 is at most a very small area of n
Acute toxicity: inhalation, IUC4#61/Ch.5.1.2
Normal and DNA polymerase-deficient Escherichia coli
Compadre, C.M., Hussain, R.A., de Compadre, R.L.L., Pezzuto,|J.M. and A.D. Kinghorn, 1987, The intensely sweet|sesquiterpene hernandulcin: Isolation, synthesis,|characterization, and preliminary safety evaluation, J.|Agric. Food Chem., 35, 273-279, 1987
Genetic toxicity in vitro, IUC4#205/Ch.5.5
Allied Corporation. Evaluation of|[3-Glycidoxypropyltrimethoxysilane] in the|Sister Chromatid Exchange (SCE) Test: In Vitro results in|Chinese Hamster Ovary Cells (Allied Corporation Report No.|MA-168-81-7; Dow Corning Corporation internal report number|1982-I0065-4122-04).
Georgian, L. et al.: Rev. Roum. Morphol. Embryol. Physiol.|26, 179-183 (1980);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Pollard, I. and Claassens, R.: Reprod. Toxicol. 6, 541-545|(1992)
Method: other: 5 mice/sex/dose group, observed for mortality , clinical signs of toxicity; weighed initially, after 1 week and at necropsy, feed consumption measured weekly
Bayer Chemicals (2003). alpha,alpha,alpha-Trichlorotoluene -|Internal Data on Production, Processing, Use Pattern, and|Workplace Exposure (Unpublished).
Chernoff, N. and Kavelock, R.J.: Short-term Bioassays in the|Analysis of Complex Environmental Mixtures III, 417-427|(1983);|cited in: RIFM database, location no. 8327
Takiguchi, H. (1985) Bulking of activated sludge and its|regulation. Technical Information Center. (in Japanese)
Gelfins F (1927) Ueber die Wirkung der chronischen|Para-nitrochlorbenzolvergiftung auf das Blutsystem.|Menninger, Wuerzburg: cited in Watrous RM and Schulz HN|(1950) Ind Med Surg 19: 315-320
Chemicals Evaluation and Research Institute (2004). Water|Solubility Study of 4-ethylmorpholine. Report Number 805291.
mean diameter 9.2 nm. The standard deviation is calculated to be 2.7 nm.(migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.)
Repeated dose toxicity: inhalation, IUC4#118/Ch.5.4
Huels AG (1992). Bestimmung der biologischen Abbaubarkeit|von Isophoron im DOC-DIE Away Test. Report No. DDA-07|(unpublished).
Method: other: Directive 92/69/EEC, part 2 C.4/A
Dow Corning|Corporation, physical properties database.
Reshetyuk AL, Shevchenko LS (1966). Toxicity of aerosols of|soda and 'sulfonol' solutions. Donetsk Occupational Health|Research Institute.
USEPA. 2000. KOWWIN. Version 1.67. EPIWIN (Estimation Program Interface for Windows). Version 3.12. Office of Pollution Prevention Toxics (OPPTS) and Syracuse Research Corporation.
Lewis RJ (1993). Hawley´s Condensed Chemical Dictionary|(12th ed.). Van Nostrand Reinhold, New York, p. 1193.
Solubility in organic solvents / fat solubility, IUC4#21/Ch.2.6.1
BSB 2000: Toxicity of sodium tetrapropenyl benzene|sulfonate, cocos dimethylamine, di hardened tallow dimethyl|ammonium chloride and tallow alkylamine on the nematode|Caenorhabditis elegans in artificial sediment.
Kirk-Othmer Encyclopedia of Chemical Technology (1997)|Fourth Edition, Vol. 24, (1997), J. Wiley & Sons, Inc.
Brooks TM, Gonzales LP, Calvert R, Parry JM (1985) The|induction of mitotic gene conversion in the yeast|Saccharomyces cerevisiae strain JD1. Prog Mut Res 5: 225-228
Method: other: according Davis et al., 1975, Mutation Res. 29, 301
Appel, M.J. and D.H. Waalkens-Berendsen. Butyltrichlorostannane [CAS # 1118-46-3]: Sub-chronic (13 week) oral toxicity study in rats, including a reproduction/developmental screening study. TNO Nutrition and Food Research. TNO Report V3962, May 2004.
BASF AG, Department of Product Safety, unpublished|calculation, 18.02.2002
Boyd, E.M., Shanas, M.N. (1961). The acute oral toxicity of|potassium chloride. Arch. Int. Pharmacodyn. Ther.|133:275-283.
Weisbrod, D. and Seyring, B., Toxikol. Anal., Probleme bei|Loesungsmittelexpos., 55-59, 1980
Method: other: comparable to OECD Guide-line 401
Heinemann GW, Kaufmehl M, Hilfiker R, Schmidt E, Erni H|(1997). Determination of the water solubility of TINOPAL|DMS-X pur extra (ID: 040705.6). Report on Analytical Test|No. 97-1230, Ciba Specialty Chemicals, Grenzach, Basel,|Switzerland.
Affiliated Medical Enterprises, Inc (AME). 1971. Final Report. Primary Eye Irritation of Dibutyl Tin Dichloride (DM-8122) in Rabbits. Study conducted for M&T Chemical Co. Contract No. 120-697-12-70. March 15, 1971.
Furuya T, Yoshikawa T, Kimura T, Kaneko H (1987): Production|of tocopherols by cell culture of safflower. Phytochem|26(10): 2741-2747.
Ono Y, Somiya I, Kawaguchi T (1992) Genotoxic evaluation on|aromatic organochlorine compounds by using UMU test. Wat Sci|Tech 26: 61-69
Method: other: the culture with the test strain was incubated with the test compound for 4 hours at 37 deg.C. and then ß-galactose activity in the cells was assayed
Vasilenko, Zvezdai (1981): Gig. Tr. Prof. Zabol, 25(8).
Lashmar UT, Hadgraft J and Thomas N (1989). Topical|application of penetration enhancers to the skin of nude|mice: a histopathological study. J. Pharm. Pharmacol. 41,|118-122.
Nakamura S, Oda Y, Shimada T, Oki I, Sigimoto K (1987)|SOS-inducing activity of chemical carcinogens and mutagens|in Salmonella typhymurium TA1535/pSK1002. Mut Res 192:|239-246
Method: other: umu gene expression according Oda et al., 1985
Glancer-Soljan M, Soljan V, Dragicevic TL, and Cacic L|(2001). Aerobic degradation of formaldehyde in wastewater|from the production of melamine resins. Food Technol.|Biotechnol. 39(3), 197-202.
Bringmann G. & Kuehn R., Vergleich der Wirkung von|Schadstoffen auf flagellate sowie ciliate bzw. auf|holozische bakterienfressende sowie saprozoische Protozoen,|gwf-wasser/abwasser 122 (7): 308-313, 1981 (95)
Kemira Oyj (2007). Applicant and identity information on|formic acid, 21 Jun 2007, unpublished.
Levy A (1973). The Photochemical Smog Reactivity of Organic|Solvents. Adv. Chem. Ser. Amer. Chem. Soc. 124, 70-94.
Hüls AG (1981). Mutagenitätsuntersuchung von Isophorondiisocyanat mit Hilfe des Salmonella typhimurium/Mikrosomen-Mutagenitäts-Tests nach Ames. Report No. 8134 (unpublished).
Wellens H (1990) Zur biologischen Abbaubarkeit mono-und|disubstituierter Benzolderivate. Z Wasser Abwasser Forsch|23: 85 - 98
Mitchell, A.D., Rudd, C.J., Caspary, W.J. (1988). Evaluation|of the L5178Y mouse lymphoma cell mutagenesis assay:|Intralaboratory results for sixty-three coded chemicals|tested at SRI international. Env. Molecular Mutagenesis|12(13):37-101.
HYDROWIN, v1.67. Aqueous Base/Acid-Catalyzed Hydrolysis. EPI Suite, v. 3.11, U.S. Environmental Protection Agency, 2003.
Method: other: rat mean weight: 200 g, food and water ad libitum, appl. by gavage, dosing volume: 1 ml, 6 different doses, observation period: 14 d, statistical evaluation according to Bartlett, determination of LD50 with probit method
Toxicity to microorganisms, IUC4#46/Ch.4.4
BASF AG, Laboratory of Ecology, unpublished data, 14.02.1979, No information
Method: other: Activated Sludge Respiration Inhibition Test
Greenlee. T.W. (1975) Polym. Sci. Technol. 9A:339.
Williams, G.M. et al., Prog. Mutat. Res. 5, 341-345 (1985)
Snoeij, N.J. and Buse-Pot, T.E. (1992), "Acute oral|toxicity with epsilon-caprolactone in the rat", Solvay|Duphar Int. Doc. No. 56645/92/91
Matter, B.E. and Grauwiler, J.: Mutat. Res. 23, 239-249|(1974); and|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Klimmer, O.R. 1969. Arzneimittel-Forsch. 19:934. IN Deutsche Forschungsgemeinschaft. 1993. Di-n-octylzinnverbindungen. In: Maximale Arbeitsplatzkonzentrationen und biologische Arbeitsstofftoleranzwerte (ed. H. Greim). Verlag Chemie, Weinheim.
Eder, E. et al., Molecular mechanisms of DNA damage|initiated by alpha, beta-unsaturated carbonyl compounds as|criteria for genotoxicity and mutagenicity, Environmental|Health Perspectives, 88, 99-106 (1990)
Genetic toxicity in vivo, IUC4#129/Ch.5.6
Degussa AG (2003), unpublished report. Estimation of the|Soil or Sediment Adsorption Coefficient (Koc) of Diethyl|malonate CAS-No.: 105-53-3 by Quantitative Structure|Activity Relationship (QSAR-Method = Calculation) Degussa|AG-Reg-No. 2003-0430-DKB.
Method: other: (calculation) PCKOCWIN (PC-KOC (c)) Program, Version 1.66, Syracuse Research Corporation, Merrill Lane, Syracuse, New York, 13210, U.S.A., 2000
Richardson ML, Bowron JM (1985) The Fate of Pharmaceutical|Chemicals in the Aquatic Environment. J Pharm Pharmacol 37:|1 - 12
Hazardous Substances Data Bank (HSDB) (2001). Online|database.
Method: other: OECD Guideline 406, Skin Sensitisation
Toxicity to soil microorganisms, IUC4#8/Ch.4.4
RBM Study Report No. 950104 (1995). Instituto di Recerhe Biomediche, Via Ribes 1, 10010, Colleretto Giacosa, Italy.
BASF AG, Department of Toxicology, Study of the prenatal|toxicity of Isobutylidene-di-urea in rats after oral|administration (gavage), unpublished study (90/727) for BG|Chemie, Heidelberg. 1991
Method: other: range-finder for OECD 414
Govind R, Lei L, Tabak H (1996). Development od structure|biodegradability relationships (SBRs) for estimating|half-lives contaminants in soil systems. W.J.G.M.|Peijnenburg and J. Damborsky (eds.). Biodegradability|prediction, 115-138.
Biodegradation in water: screening tests, IUC4#195/Ch.3.5
Method: other: intraperitoneal initiation-dermal promotion assay (see TC)
BASF AG, Experimental Toxicology and Ecology, unpublished|study, Project No. 00/0359/60/1, 30.03.2001
Rom WN, 1992. Environmental and Occupational Medicine. 2nd|Edition. Little, Brown and Co., Boston, MA.
Goh, C.L., Ho, S.F. (1993): Contact Dermatitis 28, |134 - 138
Daubert TE and Danner RP (1989) as quoted in: SRC PhysProp|Database, 17.06.2003
Hoechst AG. 1992.: Interne Berechnung der Abt. [Internal determination in the division] UCV (19.05.1992)
Method: other (calculated): Medchem Software CLOGP3, Release 3.42, Pomona College, Clermont CA
Hampson. Chemical kinetic and photochemical data sheets|foratmospheric reactions. FAA-EE-80-17. Washington, DC: US|Dept of Transportation (1980).
Test No. 850212, AUTORADIOGRAPHIC DNA REPAIR TEST ON RAT|HEPATOCYTES, CIBA-GEIGY LIMITED, unpublished report
Schwarz, G. and E. Eich. 1984. Einflub von agroclavin auf wachstum und sekudarstoffproduktion von saccaromyces uvarum und blakeslea trispora. Pharmazie. 39:H8.
D'Addario, A.P. and Jagannath, D.R.: Environ. Mutagen.|3, 325 (1981) (abstr.)
Wagner R (1976). Untersuchungen über das Abbauverhalten|organischer Stoffe mit Hilfe der respirometrischen|Verdünnungsmethode. II. Die Abbaukinetik der Testsubstanzen.|Vom Wasser 47, 241-265.
BOD5 Method: other: respirometric dilution method
6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol (IUC4 DSN 36)
Lundgren T (2001). TOSS treatment of 2,4-DNT contaminated|soil at an explosives manufacturing plant in Sweden. In:|Magar VS, von Fahnestock FM, Leeson A (eds.). 6th|International In Situ and On-Site Bioremediation Symposium,|San Diego, CA, United States, June 4-7, 2001. Volume 6,|127-131. Battelle Press, Columbus, Ohio.
Method: other: Two step bioremediation process for soil
European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Method: other (calculated): acc. to Atkinson: SRC-AOP for Microsoft Windows
Phototransformation in air, IUC4#70/Ch.3.1.1
Method: other: 2 rabbits (male and female), 500 ul/one ear of the rabbit fixed with a plaster, the other ear served as control, rinsing post exposure, reading 24h, 48h, and d 2, 4, 5, 6, 7, post exposure observation time: 7 d
Acute toxicity: inhalation, IUC4#37/Ch.5.1.2
Formaldehyde, oligomeric reaction products with aniline
Edwards, D.A. et al.: Fund. Appl. Toxicol. 23, 179-187|(1994), No information
Human lymphocytes (peripheral blood mononucleated cells)
In vitro evaluation of HCFC-124 for chromosome aberration in|human lymphocytes, E.I. du Pont de Nemours and Co., Haskell|Laboratory for Toxicology and Industrial Medicine, Delaware,|USA, HLR Report No. 367-90, October 1990.||Malley, L.A., Frame, S.R., Elliott, G.S., Bentley, K.S.,|Brock, W.J., Trochimowicz, H.J. and Rusch, G.M. Chronic|toxicity, oncogenicity, and mutagenicity studies with|chlorotetrafluoroethane (HCFC-124). Drug and Chem Toxicol,|Vol 21 (4), 417-447, 1998.
Method: other: EPA OTS 798.5375 and OECD Guide-line 473
Beilstein Database. Copyright 1988-2001 Beilstein Institut|zur Foerderung der Chemischen Wissenschaften. CrossFire|Beilstein, licensed by MDL Information Systems GmbH,|research update: 19 Jul 2002.
Method: other: Biodegradation in River Water. Simulation experiment (Testfilter)
NTP, Developmental and Reproductive Toxicity, Studies and|Test Systems, Feb. 1987
Ma, T.H. et al.: Mutat. Res. 138, 157-167 (1984), No information
BASF AG, Labor fuer Umweltanalytik, unveroeffentlichte|Untersuchung, 09.01.1989
Morris S.M. & Heflich R.H. (1984). Mutation Res. 126, 63.
Method: other: Chromosomal aberration test
Mastalski K. 90-day subacute oral toxicity study with FA-15|in Beagle dogs. Addendum report IBT No. J9450, October 15,|1971. Industrial Bio-Test Laboratories, Northbrook, IL, USA.
Liu D, Thomson K, and Anderson AC (1984). Identification of|nitroso compounds from biotransformation of|2,4-dinitrotoluene. Appl. Environ. Microbiology 47 (6),|1295-1298.
Method: other: anerobic test in cyclon fermentors
BASF AG, 1989, Analytical Laboratory, Dampfdruck:|2-Methyl-2-hepten-6-on, unpublished study, BRU 89.117, 09|May 1989
Method: other (measured): dynamic with argon atmosphaere
HSDB database (through 2003/12) available online via TOXNET|at http://toxnet.nlm.nih.gov, data set reviewed 20 May 1999.
Ruddick JA, Villeneuve DC, Secours V, Valli VE (1982) A|transplacental and teratological evaluation of three|trichlorotoluene congeners in the rat. Teratology 25: 72A -|73A
Method: other: effect of oral treatment on the foetal development in rats
Bringmann G and Kuehn R (1977). Befunde der Schadwirkung|wassergefährdender Stoffe gegen Daphnia magna. Z f Wasser-|und Abwasser-Forschung 10: 161 - 166.
Method: other: Immobilization test acc. to Bringmann & Kühn
Abe, S. and Sasaki, M. (1977), "Chromosome Aberrations and|Sister Chromatid Exchanges in Chinese Hamster Cells Exposed|to Various Chemicals", J. Nat. Cancer, Vol. 58, pp.|1635-1640
Saccharomyces cerevisiae D4 and Salmonella typhimurium TA1535, TA1537, TA1538, TA100 and TA98.
Bus, J.S., Wolkowski-Tyl, R., and Barrow, C.S.: Teratology. |21(2): 32A. [Abstract] (1980), as cited in Wolkowski-Tyl.
BASF AG, Department of Ecology, unpublished studies,|19.08.1986
Bridie A.L. et al (1979), Water Research, 13(7), 623-26.
Method: other: APHA Standard methods No. 231
Kirsch, P., Hildebrand, B. (1991). Report on the Acute Eye|Irritation to the Eye of Protectol PP in White Rabbits. BASF|Akteingesellschaft. Study No. 18H0634/902207, February 21,|1991. Unpublished.
NCI (1968) Evaluation of carcinogenic, teratogenic, and|mutagenic activities of selected pesticides and industrial|chemicals. National Cancer Institute, Bethesda, Maryland,|USA (PB-223159)
Beilstein, Handbook (online), BRN 1909545, BPR 79-77-6,|Pfizer & Co. US 2638483, 1951, Handbook
Turck PA. Two generation reproduction and fertility study of|C.I. fluorescent brightener 220 administered via oral gavage|in rats. Report Laboratory Study No. 795-006, August 24,|2001. MPI Research, Mattawan, USA.
Method: other: immobilization test according to Bringmann & Kühn
Kronberg L and Franzén R (1993). Determination of|Chlorinated Furanones, Hydroxyfuranones and Butenedioic|Acids in the Chlorine-Treated Water and in Pulb Bleaching|Liquor. Environ. Sci. Technol. 27: 1811-1818.
Method: other: no details on method given
Hoechst AG (1987): Unveröffentl. Unters. (Ber.-Nr. W87-417)
Repeated dose toxicity: oral, IUC4#29/Ch.5.4
Salmonella typhimurium TA98, TA100, TA1535
BASF AG, personal communication, 12.08.2002
Grossmann, N. et al., Journal f. praktische Chemie 330 (2),|204-212 (1988)
CIBA-GEIGY, Ltd. 1983. GU2 Toxicology. Report TK13019. Acute Oral LD50 in the Rat. GU Project No. 821571. Basle, Switzerland. February 24, 1983.
Huels AG (1988). unpublished report F956. Goldorfentest nach|DIN 38412 Teil 15. Degussa AG-Reg-Nr.: 88-0650-DKO.
Method: other (calculated): QSAR estimate
Heukelekian H and Rand MC (1955). Biochemical oxygen demand|of pure organic compounds. Sewage and Industrial Wastes|27/9, 1041.
Method: other: In utero Cancerogenicity Study
cited [30] in: Bartsch, W., Sponer, G., Dietmann, K., Fuchs,|G. Arzneim.-Forsch,, vol. 26, 8, 1581-1583 (1976).
Appel, M.J. and D.H. Waalkens-Berendsen. 2004. Dichlorodioctylstannane [CASRN # 3542-36-7]: Sub-chronic (13 week) oral toxicity study in rats, including a reproduction/developmental screening study. TNO Nutrition and Food Research. TNO Report V3964, April 2004.
Method: other: similar to OECD 476; according to Myhr G. et al., Prog. Mutat. Res. 5, 555-586 (1985)
Heppolette, R. and Robertson, R.E.: Ca. J. Chem. 44:677-684|(1966).
Bringmann G., Kühn R. Comparison of the Toxicity Thresholds|of Water Pollutants to Bacteria, Algae and Protozoa in the|Cell Multiplication Inhibition Test. Water Research|14:231-241. 1980.
Salmonella typhimurium TA100, TA1535, TA98, TA1537, Escherichia coli WP2uvrA
The Goodyear Tire & Rubber Company, Laboratory Report No.|81-4-5 (1981)
Falck K, Partanen P, Sorsa M, Suovaniemi O, Vainio H (1985)|Mutascreen-r, an automated bacterial mutagenicity assay. Mut|Res 150: 119-125
CIBA-GEIGY Ltd. 1992. Report on the test for inhibitory concentration on aerobic bacteria of Irgastab T 22 M. Test No. 928290. 16.12.1992.
Microbiological Associates, Inc. 1990. |Salmonella/Mammalian-Microsome Plate Incorporation|Mutagenicity Assay (Ames Test) With a Confirmatory Assay. |MA Study Number: T9410.501014.
Acute toxicity: inhalation, IUC4#100/Ch.5.1.2
Salmonella typhimurium TA98, TA100,TA1535, TA1537, TA1538, Escherichia coli WP2uvrA
Degussa North America (2006). Degussa Corp. isophorone diisocyanate exposure questionnaire (unpublished).
Dias, E.F. and M. Alexander. 1971. Effect of Chemical|Structure on the Biodegradability of Aliphatic Acids and|Alcohols. Applied Microbiology. 22(6):1114-1118.
BASF AG (1988). Department of Ecology, report No.|9/1122/88, 26 Oct 1988, unpublished.
Method: other: according to Bringmann-Kuehn (similar to German Industrial Standard DIN 38412, part 8)
Salmonella Typhimurium TA 1535, TA 1537, TA 1538, TA 98 and TA 100
Method: other: measured (dynamic method, Ramsay Young)
Crofton, K.M., Lassiter, T.L., and Rebert, C.S. 1994.|Solvent-induced ototoxicity in rats: an atypical selective|mid-frequency hearing deficit. Hearing Research 80 (1),|25-30.
Topert, M. 1977. Einflusse verschiedener Sn-organischer Verbindungen auf den in vitro 3H-Thymidineinbau in Tumorzellen. 18.10.1977.
Method: other: in conformance with OECD 405
Method: other: according to Ames, B.N., et al., Mutat Res 31:347-364
Hooftman, R.N. and J.M. de Wolf. 2003. Trichloromethylstannane (CAS# 993-16-8): Semi-static acute toxicity test with the zebra fish Brachydanio rerio. TNO Report No. V2492/03. May 2003.
Atkinson R (1987) Environ Sci Technol 21:64-72.
BASF AG, Department of Product Safety, Expert Judgement, 26.|Jan 2004
Ministry of Health and Welfare: Japan (1995) Toxicity|Testing Reports of Environmental Chemicals, 2, 79-102.
Method: other: Guidelines for Screening Mutagenicity Testing of Chemicals (Japan)
Covance Laboratories (1999). Formi LHS. Combined chronic|toxicity and 104 week oral (dietary administration)|oncogenicity study in the rat. Unpublished interim DRAFT|study report No. 1516/30-D6154 dated October 1999. Sponsored|by Hydro Nutrition, Oslo.
NTP: Reproduction and Fertility Assessment in CD-1 Mice when|Administered in the Drinking Water, RACB84044, NTIS|PB85-205052, (1984a).
Method: other: NTP Reproductive Assessment by Continuous Breeding (RACB), according to Reel, J.R. et al.: J. Am. Coll. Toxicol. 4, 147-162
Toxicity to reproduction, IUC4#11/Ch.5.8.1
Genetic toxicity in vitro, IUC4#214/Ch.5.5
ASHRAE Fundamentals HANDBOOK 20.9 (2001)
Gregorc A, Pogacnik, and Bowen ID (2004). Cell death in|honeybee (Apis mellifera) larvae treated with oxalic or|formic acid. Apidologie 35, 453-460.
Toxicity to terrestrial arthropods, IUC4#4/Ch.4.6.4
Kirk-Othmer (1998). Encyclopedia of Chemical Technology.|Fourth edition, volume 11. John Wiley & Sons, New York, USA,|952.
Environmental Agency, Japan (1999c) Unpublished testing|report on reproduction toxicity of o-chlorobenzyl chloride|to Daphnia magna, Test No. 10043, conducted by Japan Food|Research Laboratories.
Reichardt W., 1981, Influence of methylheptenone and related|phytoplankton norcarotinoids on heterotrophic aquatic|bacteria, Can. J. Microbiol. 27, 144-147
immobilization, population growth, and length
Texas A&M University, TRC Thermodynamic Tables -|Non-Hydrocarbons, page a-5310, College Station, Texas,|31.12.1964, No information
Method: other: Continuously-fed laboratory bioreactors (similar to Coupled Units Test)
Ciba Specialty Chemicals Inc.; Report on Water Solubility;|Study No. 14017113-1; 9.8.2001.
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K|(1988) Salmonella mutagenicity tests: IV. Results from the|testing of 300 chemicals. Environ Mol Mutagen 11 (Suppl.12):|1 - 158
Tabak HH, Quave SA, Mashni CI and Barth EF (1981)|Biodegradability studies with organic priority pollutant|compounds. J. Water Poll. Contr. Fed. 53, 1503-1518.
Method: other: Static-Culture Flask-Screening Procedure
Blum, D.J.W. und Speece, R.E, Research Journal WPCF 63(3),|198-207 (1991)
Kavlock, R.J. et al.: Teratogen. Carcinogen. Mutagen. 5,|3-13 (1985);
Developmental toxicity / teratogenicity, IUC4#21/Ch.5.8.2
Bradley MO (1985) Measurement of DNA single-strand breaks by|alkaline elution in rat hepatocytes. Prog Mut Res 5: 353-357
Method: other: alkalische elution; Bradley et al., 1982
BASF AG, Department of Toxicology, Isobutylidendiharnstoff|(IBU) Ergebnis der gewerbetoxikologischen Vorprüfung, |unpublished study (XVII/341), Nov 07, 1967 , further details|in: BASF AG (2004) March 17, 2004.
Batiste-Alentorn M, Xamena N, Creus A, Marcos R (1994)|Further Studies with the somatic white-ivory sytem of|Drosophila melanogaster. Env Mol Mut 24: 143-147
Method: other: based upon the white-ivory system developed Green et al., 1986
Method: other: Directive 84/449/EEC, B.6; 1989
Degussa AG, unpublished, Report: Degussa AG - US-IT-Nr.:|79-0015-DKT (1979)
FMC Corporation, In vivo - in vitro rat hepatocyte|unscheduled DNA synthesis assay (sodium persulfate), Study|no. I90-1173, 1991.
Bayer AG (1987) unpublished data: Water Solubility of|Chlorobenzene, o-, m-, p-chlorotoluene and o- m-,|p-nitrotoluene (1987-07-13)
Toxicity to microorganisms, IUC4#62/Ch.4.4
Method: other: Reported from Japanese industry
Snyder, R.D. and Matheson, D.W.: Environ. Mutagen. 7,|267-279 (1985), No information
Method: other: Nick translation assay (DNA strand breaks)
Genetic toxicity in vitro, IUC4#182/Ch.5.5
CIT (2002) Report number 24180. Water solubility of EHTG.
CERI. (2007) Estimation with AopWin v1.91.
Schering AG. Detection of gene mutations in mammalian cells in vitro (HGPRT-test with V79 cells). Test Report No. 142402. Prepared by Cytotest Cell Research (CCR). 27.02.1989.
Method: other: Japanese Guideline by MITI of 1974; corresponds to OECD 301C Modified MITI Test I
US EPA - IRIS]|IRDC (International Research and Development Corporation)|n.d. ||cited in:|USEPA (1986)Toxicology Branch Peer Review Committee |memorandum on aliette||cited in:|USEPA; IRIS (Integrated Risc Information System, through|12/2003); |Fosetyl Al
Fischer WK, Gerike P, and Schmid R (1974).|Methodenkombination zur sukzessiven Prüfung und Bewertung|der biologischen Abbaubarkeit synthetischer Substanzen, z.B.|organischer Komplexbildner, über allgemein gültige|Summenparameter (BSB, CO2, COD, TOC). Z. Wasser Abwasser|Forsch. 7, 99-118.
BASF AG, Abteilung Toxikologie; unveroeffenlichte|Untersuchung (90/604), 15.10.91
Barilylak I.R. and Kozachuk S.Y.: Tsitol. Genet., 22, 49-52,(1988); cited in BG Chemie (ed.): 2-Methylpropanol-1, in: Toxikologische Bewertung, Ausgabe 01/97, BG Chemie, Heidelberg, pp. 3-40, (1997) as cited in IUCLID.
Method: other: cytogenetic assay by gavage (single treatment) at 1/5 of the LD50. 48 hours after gavage, cells from the bone marrow were studied for cytogenetic effects.
SiA_EC 206-203-2_Tricosafluorododecanoic_acid_en
Silverman M. and Abreu B.E. (1938), "The toxic and|anesthetic properties of certain monochloropropenes", Univ.|of California, Berkeley, Publ. Pharmacol, 1(10), 119-28.
Ruiz-Rubio, M. et al:: Mutat. Res. 147, 153-163 (1985), No information
Dubina O.N. and Maksimov G.G. Testing the use of Golden|Hamsters in Toxicological Research. Gig. Tr. Ohkhr.|Zdorov'ya Rab. Neft. Neftekhim. Prom-sti. 9:100-103. 1976.
Genetic toxicity in vitro, IUC4#191/Ch.5.5
Method: other: according to Maron, D.M. and Ames, B.N.: Mutat. Res. 113, 173-215
Hanstveit, R. 2003. Trichloromethylstannane (CAS # 993-16-8): Determination of the ready biodegradability in a Manometric Respiration Test. TNO Report No. V2492/01 (revised report). September 2003.
Gerhold, R.M., Malaney, G.W. (1966) Structural determinants|in the oxidation of aliphatic compounds by activated sludge.|J. Water Pollut. Control Fed., 38(4):562-579.
ICI (1990) "Chlorine & Sodium Hypochlorite: Assessment of|Sensory Irritation Potential in Mice", unpublished report|(CTL/L/3279) of ICI, August 1990
Method: other: Test for assessment of sensory irritation
Jager, R., Peter, H., Sterzel, W., and Bolt, H.M.: J. Cancer|Res. Clin. Oncol. 114(1): 64-70 (1988).
Taylor P.A. (1993), Environ. Toxicol. and Chem., 12,|925-930.
The Salmonella typhimurium/mammalian microsomal assay, a|report of the U.S. EPA Gene-Tox Program, Kier, L.E., et al.|Mutation Research 168(2):69-240. 1986.
Method: other: Standard Salmonella plate incorporation test, with and without PCB-induced rat liver S9 metabolic activation.
Short-term toxicity to aquatic invertebrates, IUC4#51/Ch.4.2
Das, G. & Runeckles, V.C. (1974): Effects of bisulfite on|metabolic development in synchronous chlorella pyrenoidosa.|Environ. Res. 7, 353-362
Chinese hamster fibroblast cells and human lymphoblastoid cells.
Method: other: calculated based on experimentally derived data (measured: dynamic with argon)
Tanaka, Y. (1977) Hatano Institute. Test number|77-017-0107-3. Bacterial Mutagenicity Study with KBM-603.
Zirconia Aluminosilicate Refractory Ceramic Fibres
Fahrig R.: Environ. Mutagen 9, 84,(1987)
Chemicals Evaluation and Research Institute (2004). Vapour|Pressure of 4-ethylmorpholine. Report Number 805289.
TNO (1978). Determination of the acute oral toxicity of|potassium-gluconate in rats. Centraal Instituut voor|voedingsonderzoek.
National Institute of Environmental Research (NIER), 2001. Calcium sulfate dihydrate: Bacterial reverse mutation test (Test No. G01100), Tested by KRICT, Korea.
Solubility in organic solvents / fat solubility, IUC4#500/Ch.2.6.1
Merck (1991) Institut fuer Toxikologie, unveroeffentlichter|Bericht Nr. 40/16/91 (1991) zitiert in: BG-Chemie,|Toxikologische Bewert ungen Nr. 83,|Thioglycolsaeure-2-ethylhexylester (1993)
Dow Corning Corporation (1968) Dow Corning Corporation|Internal Report No. 1968-I0065-1129-03
Geiger DL, Brooke LT and Call DJ (1990). Acute Toxicities of|Organic Chemicals to Fathead Minnows (Pimephales promelas),|Vol. V. Center for Lake Superior Environmental Studies,|University of Wisconsin-Superior.
BASF AG, 1989, Analytical Laboratory, Dampfdruck|4-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-3-buten-2-on),|unpublished study, report No. BRU 89.178, 06 July 1989
Method: other (measured): dynamic in an argon atmosphere
Iyer, V.N. and Szybalski, W.: Appl. Microbiol. 6, 23-29|(1958);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Bayer AG, unpublished data, Report No. 19909, Jan. 1991,|cited in Bayer base data set, last update 18.08.1994
NTP (National Center for Toxicologial Research): 14 Day|Repeated Dose Report On Caffeine|(3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione) in Fischer|344 Rats, Final Report, NCTR Techn. Rep. for Expt. No. 377|(NTP Expt. No. 0501103) (1982)
CIT (1993) Reverse mutation assay on bacterial Salmonella|typhimurium with 2-ethylhexyl thioglycolate. CIT report no.|10277 MMO, 19th August 1993.
Elf Atochem (1993) Technical Data Sheet Elf Atochem January|1993
Koga, Y. (1962) The effect of calcium chloride on|vegetation. Unpublished Tokuyama Corporation report. (in|Japanese)
Watanabe, K. Sakamoto, K and Sasaki, T. (1996).|Comparisons on chemically-induced mutagenicity among four|bacterial strains, Salmonella typhimurium TA102 and TA2638, |and Escherichia coli WP2/pKM101 and WP2 uvrA/pKM101:|Collaborative study. Mutation Research 361, 143-155.
Method: other: Maron, D.M. and Ames, B.M. (1983)
Method: other: Inhibition of nitrification, comparable with ISO/DIS 9509
Wiebe and Barr. Life-Sci., vol. 34, p. 1747, 1984.
Huang JC, Gloyna EF (1967) Effects of Toxic Organics on Photosynthetic Reoxygenation. USDI, Federal Water Pollution Control Administration, Technical Report 163 p (US NTIS PB-216749) (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved www.nisc.com).
CERI (2004). Water solubility study of Tetrahydrofurfuryl|alcohol: CAS No. 97-99-4. Test Number 805285. Unpublished|data.
Hansch,C., Leo,A.J., Medchem. Project Issue No. 26|Claremont, CA: Pomona College, (1985)
Schmiedel U, Determination of the partition coefficient of linalylacetate in n octanol/water, RCC UmweltChemie AG
Chinese Hamster lung fibroblast cells (CHL/IU)
Method: other: According to 24-hour cuff method of Draize et al.
Method: T31-18:Ames et al., 1975, Mutation Research, 31, 347-364; Yahagi et al., 1975, Cancer Letters, 1, 91-96
Huntingdon Research Centre Ltd., Analysis of methaphase|chromosomes obtained from CHO cells cultured in vitro and|treated with o-chloronitrobenzene, HRC Report No. BGH|7/88867, 1988 (at the request of BG Chemie)
Method: other: OECD Guide-line 473, harvest time: 8, 12, 21 hours, cytotoxicity was tested prior to testing, positive controls: mitomycin C, cyclophosphamide
BASF AG, Laboratory of Ecology, unpublished data,|(20.09.89)
Method: other: Manometric Respirometry EEC Directive 79/831, Annex V, Part C, 5.2
Method: other: ECOSAR Computer Model (in: EPIWIN)
Acute toxicity: inhalation, IUC4#57/Ch.5.1.2
BASF AG (1998). Intermediates - Brochure on Biodegradability of N-Methylpyrrolidone. Available online at http://www.basf.com/diols/pdfs/nmp_brochure_biod.pdf (query 22 Jun 2007).
Method: other: German Industrial Standard DIN 38418 Part 8
Chemicals Evaluation and Research Institute (CERI). (2001).|Report of Partition Coefficient Measurement of MMB, Report|Number 81947. Unpublished Report.
Pelikan, Z. and E. Cerny. 1970. Toxic effects of some "mono-n-butyltin compounds" on white mice. Arch. Toxikol. 27:79-84.
Osterholtz, F. D. and E. R. Pohl (1992) J. Adhesion Sci.|Technol. Vol 6. No.1, pp 127-149.
Salmonella typhimurium TA98, TA100, TA1535, TA1536, TA1537, TA1538
Method: other: according to OECD Guide-line 476, see also freetext ME
Method: other: calculation according to Bcfwin v2.15
Hüls AG (1983a). Prüfung auf hautsensibilisierende Wirkung|am Meerschweinchen von Isophorondiamin (IPD). Report No.|0124 (unpublished).
Method: other: OECD Guideline 406 (1981)
Yaws CL (1994). Handbook of Vapor Pressure. Volume 1 - C1 to C4 Compounds. Gulf Publishing Company, Houston, Texas.
Burt R.A.; Chiang Y.; Kresge A.J.: Vinyl ether hydrolysis.|XIV. 2-Methoxy-2,3-dihydropyran: concurrent reaction of|vinyl ether and acetal functional groups. Can.J.Chem. 58,|2199-202 (1980)
Ind. Health Foundation, Inc.: "Report on Caprolactam",|25.07.1990
Holmstroem, M. et al.: Acta Otolaryngol. 108, 274-283 (1989), No information
Prehled Prumyslove Toxikol. Org Latky (1986) 234 cited in: RTECS (1990).
Toxicity to terrestrial plants, IUC4#60/Ch.4.6.2
BASF AG, Department of Toxicology, Study on acute dermal|toxicity of prenol in the rat, unpublished report (78/453),|23 April 1979
BASF AG (2007). Protectol FM 85 - Material Safety Data Sheet|according to Regulation (EC) No. 1907/2006. Revised 12 Jun|2007.
Appearance/physical state/colour, IUC4#9/Ch.1.1.1
Melting point/freezing point, IUC4#90/Ch.2.1
Method: other: Biodegradation test in an electrolytic respirometer
Sellakumar AR, Snyder CA, Solomon JJ, Albert RE (1988).|Carcinogenicity of formaldehyde and hydrogen chloride in|rats. Toxicol Appl Pharmacol 81, 401-406.
BASF AG (1988), Analytisches Labor; unveroeffentlichte Untersuchung (J.Nr.124835/01) vom 26.05.88
Method: other: Differential killing assay
Dent JG and Graichen ME (1982). Effect of hepatocarcinogens|on epoxide hydrolase and other xenobiotic metabolizing|enzymes. Carcinogenesis 3, 733-738.
Gerike, P. and Gode, P., Chemosphere 21(6), 799-812|(1990)
JETOC (Jap. Chem. Ind. Ecolog. Toxicol. Inform. Center)|(2000). Mutagenicity Test Data of Existing Chemical|Substances: Suppl. 2, 33-39, 71, 170-171.
Method: other: preincubation method according to Ames, Mutat. Res. 31,347(1975); Maron, Mutat. Res.113,173(1983); highest doses used: cytotoxic, positive controls, solvent control (see also freetext ME)
Clariant GmbH, (1983) Unpublished testing report titled "A|Mutagenicity Screening of Ortho-Chlorbenzylchlorid D, in|Bacteria (Ames Test)", Report No.: 83.0517, 23.09.1983,|conducted by HOECHST AG, Pharma Research, Exp. Pathology.
Bomhard E. et al. (1982), Toxicol. Lett. 14, 189-194
Method: T26-16:comparable to OECD guideline 408
Wells Laboratories, Inc. 1975. Report on Inhalation LC50 in Rats. Laboratory No. G-464. 3.10.1975.
Schering AG. 1989. Die Temperaturabhaengigkeit des Dampfdrucks von ZK 24 942 (Tetra-n-butylzinn). Study No. 89/118.
Kawai, A. et al.: Jpn. J. Ind. Health 29, 34-54 (1987)
Method: other: preincubation method (only engl. abstract available)
Method: other: Acute Dermal Toxicity; Semi-Occlusive test
Method: other: according to Draize et al., J. Pharm.(Lond.) 82, 377 (1944): induction exposure by skin painting with a 3 % solution in acetone, challenge exposure by dermal application of a 0.3 % solution in acetone
Method: other: acute toxicity test, "flow through bioassay"
Short-term toxicity to fish, IUC4#86/Ch.4.1
BASF AG (1982). Department of Ecology, unpublished data, report No. 1/0048/2/82-1/82/53/476/ A 1/15, 04 Jun 1982
Method: other: German Industrial Standard DIN 38 412 Part 11
Sabine & Hayes; Arch. Ind. Hyg. Occup. Med. 6, 174-177|(1952)
Skin irritation / corrosion, IUC4#110/Ch.5.2.1
Chapin R, Gulati D, Mounce R (1997) 4-Chloronitrobenzene.|Environm Health Persp 105 [Suppl.1]: 289-290
Method: other: according Clive et al., 1979, Mutation Res. 59, 61
Huntingdon Life Sciences Ltd. (2003d). Algal Growth|Inhibition Assay. Project ID CSS 029. Huntingdon Life|Sciences Ltd., Cambridgeshire, England.
Lipton and Rotariu (1941), cited in Withers R.M.J.and Shaw|J.P.H., Mod. Chlor-Alkali Technol., 4, 51-61 (1990)
Acute toxicity: inhalation, IUC4#56/Ch.5.1.2
Fassett, D.W. (S. 1968) in: Industrial Hygiene and|Toxicology, Ed. Patty, F.A. New York-London-Sidney (1962)
Reported in AIDA (13/11/92)-ALSTOFF INFORMATION Date Bank |from BASF AG (1980). Ecological Laboratory-Unpublished Data.
Bayer AG 1975-1980, Internal Study, Prüfung auf biologischen|Abbau - Document not available
Method: other: "geschlossener Flaschentest"
Günzel P and Richter KD (1968b). Isophorone: LD50 acute|dermal rat - single administration, Schering AG, Report No.|T 6.
Hüls AG (1995). Bestimmung der Auswirkungen von Vestanat IPDI auf das Schwimmverhalten von Daphnia magna. Report No. DK-654 (unpublished).
Schultheiss (1957) cited in: Etain Cronin, Contact |Dermatitis, Churchill Livingstone, Edinburgh, London, |New York, 1980, p. 807
Hulzebos EM, Adema DMM, Dirves-van Breemen EM, Henzen L, van|Dis WA, Herbold HA, Hoekstra JA, Baerselman R, van Gestel|CAM (1993) Phytotoxicity Studies with Lactuca sativa in Soil|and Nutrient Solution. Environ Toxicol Chem 12: 1079 - 1094
Elf Aquitaine Production Research Laboratory (1995) Internal|company data
Asplund D, Konberg L, Sjöholm R, Munter T (1995). Reaction|of mucochloric acid with adenosine: formation of|8-(N6-adenosinyl)ethenoadenosine derivatives. Chem Res|Toxicol 8: 841-846
Method: T14-06:DOT Skin Corrosivity, 49 CFR 173.240
Degussa: 94-0255-DGO, Determination of the biodegradability|of DYNASYLAN GLYMO, DOC-DIE AWAY TEST. 1994.
Nishino SF, Spain JC, Lenke H, Knackmuss H-J (1999).|Mineralization of 2,4- and 2,6-dinitrotoluene in soil|slurries. Environ. Sci. Technol. 33, 1060-1064.
Cesarone, C.F. et al.: Arch. Toxicol. Suppl. 5, 355-359|(1982);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Senczuk W, Rucinska H (1984). Bromat. Chem. Toksykol. 17,|51; zitiert in: Toxikolog.-arbeitsmed. Begruendung von|MAK-Werten. VCH, Weinheim (1986).
Method: other: according to Wuergler, F.E. et al. in: Kilbey, B.J. et al. (eds.): Handbook of mutagenicity test procedures, Elsevier, Amsterdam; pp. 335-373
Hauser, M. and Haselwandter, K. (1990). Soil Biol. Biochem.|22, 1, 113-114.
Ciba (1989g). Test for Acute Toxicity of Metilox (TK 10027)|on Daphnia magna. Unpublished report # 894081. June 5, 1989.
Ristau, C., Bolt, H.M. and Vangala, R.R.: Arch. Toxicol. |64(3): 254-256 (1990).
Genetic toxicity in vitro, IUC4#281/Ch.5.5
Levin, D.E. et al.: Proc. Natl. Acad. Sci. USA, 79,|7445-7449 (1982), No information
Motolese, A. & Seidenari S., Contact Dermatitis 30, 49-50|(1994)
Repeated dose toxicity: dermal, IUC4#39/Ch.5.4
Pellmont, unpublished data, cited in: US Department of|Commerce, National Technical Information Service PB-298 383,|Scientific literature review of aliphatic primary alcohols,|aldehydes, esters and acids in flavor usage, 5th supplement,|Flavor and Extract Manufacturer's Association of the United|States, Washington, DC, prepared for Food and Drug|Administration, Washington DC, Apr. 1979
BASF AG, (1985) Chronic Toxicity and Oncogenicity of Inhaled Methyl Acrylate and n-Butyl Acrylate in Sprague-Dawley Rats, Dept. of Toxicology, unpublished study, (77/1023), March 1, 1985
Salmonella typhimurium TA1535 TA1537 TA1538 TA98 TA100
Styles, V.A. et al., Prog. Mutat. Res. 5, 587-596 (1985)
Huntingdon Life Sciences Ltd. (2001). Tungsten carbide|powder DS 100. In vitro mammalian chromosome aberration test|in human lymphocytes. Unpublished Report No. SKC 033/012208,|April 12, 2001.
Method: other: Japanese standard JIS K 0102-1986-71
Bass, Powers, Dillingham (1976): J. Pharm. Sciences 65,|1525-1527
Method: other: single exposure for 0.5, 1.0, 3.0 and 7.0 h
Johnson,S.K., Texas Agricultural Extension Service , Fish|Disease Diagnosstic Lab. (report) FDDL-S3, Texas|Agricultural Extension Service, Department of Wildlife and|Fisheries Sciences, 12 p. 1974, No information
Method: other (measured): OECD TG 107 (Flask shake method)
Method: other: Amtsblatt der EG L133 Teil C
Boyd, E.M. et al.: Can. J. Physiol. Pharmacol. 43, 995-1007|(1967)
EPISUITE v. 3.10, U.S. Environmental Protection Agency,|April, 2001.
Method: other: Calculated using EPISUITE v. 3.10 and PCKOCWIN v. 1.66 using structural features of the molecule
Bayer AG (1984) Test on the acute toxicity to fish. Unpublished report no. 8103776-1871.
Method: other: Draft Guideline "Lethal Effects towards zebrafish - Brachydanio rerio" (LC0, LC50, LC100; 48-96 Stunden) of the Federal Environmental Agency (UBA) (June 1, 1982)
Scopas Technology Company (1984). Evaluation of chlorine|dioxide in the mouse dominant lethal assay. Litton Bionetics|Inc, report n°= 22203.
EPA OTS 798.5450 (Rodent Dominant Lethal Assay)
Allyl Alcohol Consortium (2005d). PCKOCWIN v1.66|Calculations, Unpublished Data
Fujikawa, K. et al., Prog. Mutat. Res. 5, 319-324 (1985)
Method: other: (Code of Federal Regulations, Title 16, Section 1500.42)
Acute toxicity: dermal, IUC4#25/Ch.5.1.3
Hazardous Substance Data Bank (HSDB) Accessible online at:|http://toxnet.nlm.nih.gov/cgi-bin/sis/search
Acute Oral toxicity in Rats: Test report number|76-003-0101-J, From the Tejin Institute.
Chemicals Evaluation and Research Institute (CERI). (2001).|Report of Melting Point Measurement of MMB, Report Number|81944. Unpublished Report.
BASF AG, Labor Oekologie; unveroeffentlichte Unter-suchung, (No. 9/1890497, Date: 30. 05. 1989)
Wilhelm, E., Battino, R., Wilcock, R.J., 1977. Low pressure|solubility of gases in liquid water. Chem. Rev.,|77:219-262.
BASF AG, Product Safety, Subchronic toxicity study in Wistar|rats, administration in drinking water for 3 months,|unpublished report (00/274), project no. 52C0274/00099, 11|April 2002
Covance Laboratories (1998). Formi LHS. Reverse mutation in|four histidine-requiring strains of Salmonella typhimurium|and on tryptophan-requiring strain of Escherichia coli.|Unpublished study report No. 1516/10-D5140 dated January|1998. Sponsored by Hydro Nutrition, Oslo.
Lockwood, D., Unpublished report of The Dow Chemical Company|(DOT skin test) (1991)
Meylan, W.; Howard, P.: Atmospheric Oxidation Programme|Version 1.5. Syracuse Research Corporation. New York (1993)
Biodegradation in water and sediment: simulation tests, IUC4#50/Ch.3.5
Hoechst AG (1978): Unveroeffentlichte Untersuchung (78.0497)
Sussmuth R & Lingens F (1976) Mutagenic actions of|chlorocholine chloride. Mutat Res 40: 229-236
Genetic toxicity in vivo, IUC4#68/Ch.5.6
McAuliffe C (1966). Solubility in water of Paraffin,|Cycloparaffin, Olefin, Acetylene, Cycloolefin, and Aromatic|Hydrocarbons. J. Physical Chem. 70, 1267-1275.
England, D.C. und Schrier, L., Acute Flow-Through Toxicity|of Tributyl Phosphate to the Gammarid Hyalella azteca.|June 18, 1990, ABC Laboratories No. 38555, Columbia,|Missouri, USA
Bayer AG (1973). Machemer L. Blankophor BBH (Natriumsalz).|Dominant-Letal-Test an der maennlichen Maus zur Pruefung auf|mutagene Wirkung. Study report No. 4167 dated 1973-07-31.
Inversk Resarch International(IRI).(1991d), Magnsson-Kligman|maximization test in Guinea pigs. Report No.6918,|Unpublished report
Method: T20-03:Magnusson-Kligman Maximization Test(Magnusson, B.,Kligman,A.M.,J.Invest.Dermat.,52,268-276,1969
Method: other: Evaluation of mutagenesis assay using two species of bacteria
BASF AG, Physikalisch-chemische Konstanten,|unveröffentlichte Untersuchung, Bericht BRU 73.82,|05.09.1973
Method: other: visual observation of cloud point and gas-chromatographic analysis of saturated phases
Nunoshiba, T. and Nishioka, H.: Mutat. Res. 202, 383|(1988);abstract no. 36, No information
Genetic toxicity in vitro, IUC4#139/Ch.5.5
Reynolds T (1977) Comparative Effects of Aliphatic Compounds|on Inhibition of Lettuce Fruit Germination, Annali di|Botanica 41, 637-648
MPI Research (1998) Acute Inhalation Toxicity Evaluation on|Trimethoxysilane in Rats. Laboratory Study Identification:|742-003
Wotzka J, Pfitzner S and Giest B (1994). Biochemical|degradability of selected organic compounds; Part 2.|Deutsche Gewaesserkundliche Mitteilungen 38, 10-17.
Biodegradation in water and sediment: simulation tests, IUC4#12/Ch.3.5
Paschin, Y.V. & Bahitova, L.M. (1984): Mutation Res. 137,|57-59
Genetic toxicity in vitro, IUC4#272/Ch.5.5
Van Aken B and Agathos SN (2002). Implication of manganese|(III), oxalate, and oxygen in the degradation of|nitroaromatic compounds by manganese peroxidase (MnP). Appl.|Microbiol. Biotechnol. 58, 345-351.
Biodegradation in water: screening tests, IUC4#120/Ch.3.5
Craft, T.R. et al.: Mutat. Res. 176, 147-155 (1987), No information
Genetic toxicity in vitro, IUC4#456/Ch.5.5
TSCATS: OTS 0510383, Doc. I.D.: 878216455, 11.23.1951, Union Carbide Corp. cited in IUCLID (2000).
Niimi, A.J. et al., Octanol/water partition coefficients and|bioconcentration factors of chloronitrobenzenes in rainbow|trout (salmo gairdneri). Environmental Toxicology and|Chemistry 8, 817-823 (1989)
Method: other: 30 fish exposed to 780+/-130 ng TS/l in a flow-through system; aceton used as solvent; samples of 6 fish each analysed at 5,12,20,28 and 36 days of exposure; duplicate water samples taken every 3 or 4 days; GC analysis
Ministry of International Trade and Industry (MITI) (1992):|Chemicals Inspection and Testing Institute (CITI) (ed.);|Japan Chemical Industry Ecology - Toxicology and Information|Center 1-27, 3-37
Biodegradation in water: screening tests, IUC4#58/Ch.3.5
Mackay, D., Shui, W.K., 1981. A critical review of Henry's|Law Constants for chemicals of environmental interest. J.|Phys. Chem. Ref. Data, 10: 1175-1199.
Gordon, V.C. (1992), Utilization of Biomacromolecular In|Vitro Assay Systems in the Prediction of In Vivo Toxic|Responses, Lens Eye Toxic. Res. 9(3+4), 211-227
Loprieno, N. et al., Prog. Mutat. Res. 5, 297-306 (1985)
Norris, J.C. and Kintigh, W.J. (1991), "Caprolactone:|Nine-Day Vapor Inhalation Study on Rats", Bushy Run Research|Center, Report No. 54-2
Gage JC (1970). The subacute inhalation toxicity of 109 industrial chemicals. Brit. J. Ind. Med. 27, 1-18.
Waggy FT, Conway RA, Hansen JL, Blessing RL. 1994.|Comparison of 20-d BOD and OECD Closed-Bottle Biodegradation|Tests. Environ Toxicol Chem, 13: 1277-1280.
Kaiser, K.L.E. et al., QSAR of acute toxicity of|mono-substituted benzene derivatives to photobacterium|phosphoreum. QSAR Environ. Toxicol., Proc. Int.|Workshop, 2nd Meeting Date 1986, Edited by Kaiser, K.L.E.,|Reidel: Dordrecht, Neth., 153-168 (1987)
US EPA (1994): Acute (96-hour) toxicity of sodium|metabisulfite to bluegill with cocer letter dated 04/13/94.|OTS0572412
LISEC (1999). Acute Toxicity of 5-Ethylidene-2-Norbornene|for Daphnia magna. Report No. WE-01-214. LISEC, Craenevenne,|Genk, Belgium.
Method: other: OECD (1984) Guideline 202; Annex to Dir. 92/69/EEC (1992): Part C.2: Acute Toxicity for Daphnia; USEPA (1996) 712-C-96-114: OPPTS 850.1010, ISO 6341 (1989(E))
E.I. du Pont de nemours and Company, Haskell Laboratory for|Toxicology and Industrial Medicine, unpublished data,|Haskell report No. 677-76, Sept. 10, 1976
National Institute of Environmental Research (NIER), Korea, The Acute Toxicity of Calcium sulfate dihydrate to Daphnia magna (Report No. EG02088, tested by KRICT), 2003
BASF AG, Laboratory of Ecology and Environmental Analytics,|unpublished data (1987)
ammonium mercaptoacetate (IUC4 DSN 2706)
IIT Research Institute. 1991. A Segment II Inhalation|Teratology Study of Isophthalic Acid (IPA) in Rats. Study|No. 1463.
Method: other: Segment II Inhalation Teratology Study
Dunn, B.J. (1978) Test For Eye Irritants, Toluene diamine, Allied|Chemical Corporation, Project No.MA-12-77-01, 8.9.1978.
Smyth jr. HF, Weil CS, West JS and Carpenter CP (1969). An|exploration of joint toxic action: twenty-seven industrial|chemicals intubated in rats in all possible pairs. Toxicol.|Appl. Pharmacol. 14, 340-347.
Method: other (calculated): SRC Logkow v1.54 Computer Program, Syracuse Research Corporation
ECETOC Anaerobic Biodegradation (Technical Report No. 28)
Schafer E.W., Bowles W.A., Hurlbut J. (1983), The acute oral|toxicity, repellency and hazard potential of 998 chemicals|to one or more species of wild and domestic birds: Arch.|Environm. Contam. Toxicol. 12, 355-382
Salmonella typhimurium TA97a, TA100, TA102 and TA104
BASF Corporation. (1996). Ames-Test, performed in 1996 by|BASF AG; Project No. 40M0344/964214; unpublished results.
Method: other: Test Guidelines OECD TG 471 and TG 472 and EEC Directives 96/69 B14 and B13
Huls (1993) Final Report Nr. HS-93/0103: Determination of|the skin sensitization potential of DYNASYLAN GLYMO in the|guinea pig (Buhler method). Degussa-Huls AG-Nr.:|93-0299-DGT.
Hoechst AG (1977) Gericke D Benzotrichloride Test for|Mutagenicity in Bacteria Strains in the absence and presence|of a Liver Preparation. Hoechst AG unpublished study No.|1020/77 A dated 1977-10-28
Chen LC, Lam HF, Ainsworth D, Guty J, Amdur MO (1987)|Functional changes in the lungs of guinea pigs exposed to|sodium sulfite aerosols. Toxicol Appl Pharmacol 89: 1-8
Method: other: specific investigation of respiratory function parameters
3-(methylthio)propionaldehyde (IUC4 DSN 69)
Seidell, A. (1941), Solubilities of Organic Compounds, 2nd|ed., Vol. II, D. van Nostrand Company, Inc. New York
Huels AG (1989). Unpublished study report 88/210. Cited in:|ECB IUCLID 2000.
Method: other: according to Ames, B.N. et al., Mutat. Res. 31, 347-364
Amoco Corporation (1973) Four Week Inhalation Toxicity|Assessment of Terephthalic Acid in Albino Rats. Conducted by|Food and Drug Research Laboratories, Inc. FDRL Study #1610
Weisburger E.K., 1977, Environ. Health Persp., V21, P.7-16.
Organic compound dictionary (KODANSHA) (1978). U.S. Coast|Guard, Department of Transportation. CHRIS-Hazardous|Chemical Data. Manual Two. Washington, DC.
BASF Aktiengesellschaft, Product Safety, unpublished data,|Report No.: 33M0278/994093 (2001)
All-Union Institute of Scientific and Technical Information|(Moscow, USSR)#4035-77
Method: other: Myhr et al., Prog. Mutat. Res., 5: 555-568 (1985).
Allyl Alcohol Consortium (2005f). KOWWIN v1.67 Calculations,|Unpublished Data
Acute toxicity: inhalation, IUC4#46/Ch.5.1.2
Kroeger C and Soerstroem L (1965). Dampfdruck von|Silicatglaesern und deren Bestandteilen. Glastechn. Ber.|38, 313-322
ABC Lab Inc. (1990). Acute toxicity of sodium formate to|Selenastrum capricornutum Printz. Analytical Biochemistry|Laboratories Inc., report No. 38315 for Hoechst Celanese|Corp., 16 March 1990, unpublished.
Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA1538
Kuehn, R., M. Pattard, K.D. Pernak, and A. Winter. (1989).|Results of the Harmful Effects of Water Pollutants to|Daphnia Magna in the 21 Day Reproduction Test. Water Res|23(4):495-499.
Degussa AG: Study on the toxicity towards algae of "SIPERNAT|820 A (sodiumaluminiumsilicate)". Institut Fresenius|IF-98/30557-00; unpublished report: DEGUSSA AG - US-IT-No.|98-0072-DGO, 1998
4,4'-methylenedicyclohexyl diisocyanate (IUC4 DSN 2900)
Salmonella typhimurium TA98, TA100, TA1538, Saccharomyces D4
Bringmann,G. et al., Zeitschrift fuer Wasser- und Abwasser-|Forschung 13(5), 170-173, (1980)
Urbanyi B. et al., Toxicity of methanol, DMSO and glycerol|on carp (Cyprinus carpio) embryos in different developmental|stages, Theriogenology 47(1): 408, 1997 (83)
Method: other: OECD Guideline 104 "Vapour pressure curve"
Schiffmann D. et al (1983), Cancer Letters, 20, 263-69.
Method: other (calculated): AOP Computer Program, Vers. 1.53, Syracuse Research Center (based on method of Atkinson, see below)
Vasilenko, N.M. et al. (1981) Gig. Tr. Prof. Zabol., 25(8),|50.
Method: other: Pezzuto et al., Proc. Natl. Acad. Sci. USA, 82, 2478, 1985
Thompson, J.A.J., et al. 1985. Organotin Compounds in the Aquatic Environment. National Research Council of Canada.
Microbiol Associates Inc., Valentine O (1996) Salmonella|plate incorporation mutagenicity assay (Ames Test) with a|confirmatory assay. Lab Study No TE344.501132, November 07,|1996 (at the request of Berufsgenossenschaft der Chemischen|Industrie, Heidelberg)
Method: other: Ames, Mutat. Res. 31, 347 (1975); Maron, Mutat. Res.113, 173 (1983) see also freetext ME
CRC Handbook of Chemistry and Physics (2000).
Chemical Inspection and Testing Institute, Japan (1999):|report on partition coefficient between 1-Octanol and water
Caujolle, F., M. Lesbre, and D. Meynier. 1956. The effect of aliphatic chains branching on the toxicity of tetra alkyl tin compounds. Annales Pharmaceutiques Francaises. 14:88-97. (in French)
ELF ATOCHEM S.A. (1999) THIOGLYCOLATE DE 2-ETHYLHEXYLE.|Inhibition de la croissance des algues. H. Thiébaud, CAL. |Etude n° 4864/97/A.
Haubenstricker ME, Meier PG, Mancy KH and Brabec MJ (1990).|Rapid toxicity testing based on yeast respiratory activity,|Bull. Environ. Contam. Toxicol. 44, 669-674.
Method: other: Oxygen Electrode Respiration Test
Lockwood, D.D. and Borrego, V. (1980) DOT (Department of|Transportation) test for corrosiveness to skin of|aminoethylpiperazine 98. Unpublished report of The Dow|Chemical Company.
BASF AG, Department of Toxicology, unpublished data,|(XXV/436), 16 Sept. 1976b
Martin CN, Campbell J (1985) Tests for the induction of|unsheduled DNA repair synthesis in HeLa cells. Prog Mut Res|5: 375-379
Method: other: scintillation counting of extracted DNA
Bayer AG, department of toxicology: unpublished results,|report no. 16998, 08-08-88, No information
Eyre, J.F. (1977) Unpublished data of Air Products, 15 September,1977. NTIS/OTS 206427, Doc I.D. 878213667 (1983)
S. typhimurium strains TA1535 and TA1538
Ministry of Health and Welfare: Japan, Toxicity Testing Reports of Environmental Chemicals 4, 557-560 (1996)
Bayer AG 2000, Internal Study, Toxicity of BHT to activated|sludge
Method: other: Directive 88/302/EEC, Part C (Test for respiratory rate) (1988)
Salmonella typhimurium, strains TA 98, TA 1538, TA 100, TA 1535 and TA 1537 and Escherichia coli, strain WP2 uvrA
DuPont (1985). Long-term inhalation study with 1,4-dichlorobutene-2 (DCB) in rats -final report-. Haskell Laboratory, Report No. 477-85 from September 24, 1985 (NTIS OTS 509754).
Mercier M, Gilbert P, Roberfroid M, Poncelet F (1978)|Mutagenic study of chlorinated derivates of azobenzene. Arch|Int Phys Biochem 86: 950-951
Method: other: according to Ames BN et al. (1975) Mutat Res 31, 347-364 and Green MHL et al. (1977) Mutat Res 48, 287-294
Baer RL et al. (1955): Studies on Allergic Sensitization to|Certain Topical Therapeutic Agents. Arch Derm 71, 19-23
Lund FA, Rodriguez DS. (1984) Acclimation of activated|sludge to mono-substituted derivations of phenol and benzoic|acids. J Gen Appl Microbiol 30, 53-61
Merrifield, J. (2003) Personal Communication.
Method: other: comparable to OECD 201 (Algae, Growth inhibition test, 1984)
MOE, Japan (1996) Ministry of Environment: unpublished report of acute immobilisation study of N-tert-butyl-2-benzothiazonylsulphenamide to Daphnia magna.
Tin Research Institute (1973) TRIPA7 -,1,73
Allied Corporation. Acute Oral Toxicity in Rats (Allied|Corporation Project|No. MA-31-78-1).
Hoechst AG (1995): EG-Sicherheitsdatenblatt beta-Naphthol|DS(19.12.1995)
Hüls AG, Verfahrenstechnik (1973). Vapour pressure curve|"Laurinlactam". VT-Kartei 17.01.73 (unpublished)
Method: other: Part of a vapour pressure curve. Knowledge of the equipment available by the time of testing indicates performance comparable to OECD TG 104.
Reyna MS. Two-year chronic oral toxicity study with FA-15 in|Albino rats. Report IBT No. B516-B, December 28, 1973.|Industrial Bio-Test Laboratories Inc., Northbrook, IL, USA.
Paulet G and Vidal Mme: De la toxicité de quelques esters|acryliques et méthacryliques de l`acrylamide et des|polyacrylamides. Arch. Malad. Profess. Med. Travail Sec.|Sociale 36, 58-60 (1975)
Golden Syrian hamster embryo cells (diploid)
Soni G, Bhatia I (1980) Toxicity of phenolics and related compounds to Fusarium oxasporium Schlecht and effect of pH on their toxicity. Indian Journal of Agricultural Science 50(10):772-777.
Kuehn, Birett: Merkblaetter für gefaehrliche Arbeitsstoffe,|10th Ed. 1992, Ecomed Verlag, Stand: 1. April 1994.
Kanto Denka Kogyo (2002). MSDS of dicyclohexylamine.|Reference number: S-007.
Green MHL (1984). Mutagen testing using trp+ reversion in|Escherichia coli. In: Handbook of Mutagenicity Test|Procedures. Kilbey BJ, Legator M, Nichols W and Ramel C|(Eds.). 2nd edition, pp.161-187. Elsevier Science Publishers|BV, Amsterdam.
Method: other: Similar to methods described in OECD 471, and by Green (1984)
Hoechst AG (1986) p-Nitrotoluol Prüfung auf Augenreizung|beim Kaninchen. Unveröffentlichter Bericht Nr. 86.0362,|26.03.1986
Huntingdon Life Sciences Ltd. (1999). Tungsten carbide|powder - Pure. Acute dermal toxicity to the rat. Unpublished|Report No. ITU 015/982706/AC, June 24, 1999.
BASF (DIN 52900) Safety Data Sheet-DIMETHYLACETAMIDE-June|1990. (Du Pont-Haskell Laboratory-Internal DMAC Review, Oct.|1988).
BASF AG (1987). Department of Ecology, unpublished data, journal No. 23.156/86, 27 Jan 1987
Koch HP, Hofeneder M, and Bohne B (1993). The Yeast Test: an|alternative method for the testing of acute toxicity of drug|substances and environmental chemicals. Meth Find Clin|Pharmacol 15(3), 141-152.
Method: other: cell growth inhibition assay
Toxicity to microorganisms, IUC4#25/Ch.4.4
Leo, A.J. (1978) Report on the Calculation of Octanol/Water |Log P Values for Structures in EPA Files (cited in |BiblioLine(c) 1997-2007, NISC International, Inc. All |Rights Reserved. www.nisc.com)
De Boeck M, Lombaert N, De Backer S, Finsy R, Lison D and|Kirsch-Volders M (2003). In vitro genotoxic effects of|different combinations of cobalt and metallic carbide|particles. Mutagenesis 18, 177-186.
IRDC (1976) Acute Inhalation Toxicity (LC50) Study in Rats.|International Research and Development Corporation (IRDC).|Study #: 378-004. Study Date: December 9, 1976.
Hoechst AG, Unpublished reports. Ber. 90, 1336, 1990
Skin irritation / corrosion, IUC4#80/Ch.5.2.1
Le Curieux F, Munter T, Kronberg L (1997) Identification of|adenine adducts formed in reaction of calf thymus DNA with|mutagenic chlorohydroxyfuranones found in drinking water.|Chem Res Toxicol 10: 1180-1185
Covance Laboratories (1997). Green viking. Eye irritation|study in the rabbit. Unpublished final study report No.|1516/17-1032 dated November 1997. Sponsored by Hydro|Nutrition, Oslo.
Bradford, J.C. et al.: Teratology 27, 32A (1983); abstract;|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Demnati, R., Fraser, R., Martin, J.G. Plaa, G. and Malo,|J.L. (1998): Effects of Dexamethasone on funcitonal and|pathological changes in rat bronchi caused by high acute|exposure to chlorine. Toxicol Sci, 45, 242-246.
Haut, K.T., Bell, T.J., (1998). Dowanol-PPh glycol ether:|Dermal sensitization potential in Hartley albino guinea|pigs. Dow Chemical Report No. HET K-005220-009, Laboratory|Study ID No. 971184, 7 January 1998. Unpublished.
Test on 1-octanol/water partition coefficient of Flon 124,|Krume Research Laboratories, Japan, Test No 80646, December|1991
Bridie A., Wolff C. & Winter M., BOD and COD of some|petrochemicals, Water Res 13: 627-630, 1979 (89)
BOD5 Method: other: standard dilution method (APHA No. 219)
Degussa-Huls AG (1994) Determination of the acute |effects of DYNASIL 40 On fish (in accordance with |EEC 92/69 C 1). Final Report FK 1275.|Degussa-Huls AG-US-IT-NR.94-0261-DGO 08/03/94.
strain 197/2d; strain rad3, rad18, rad52, trp2
Bayer AG (1979). Leuschner F. Schleimhautvertraeglichkeit am|Kaninchenauge von Blankophor BA 267 % bei einmaliger|Applikation. |Study reported from Laboratorium für Pharmakologie und|Toxikologie to Bayer AG dated 1979-06-15.
Schering AG. 1979. Mutagenicity Evaluation of Dibutyltin Dichloride in the Ames Salmonella/Microsome Plate Test. Litton Bionetics, Inc. Final Report. LBI Project No. 20988. December 1978 (Revised May 1979).
Method: other: Ames, et al., 1975; McCann, et al., 1975
Seiler J (1977) Inhibition of testicular DNA synthesis by chemical mutagens and carcinogens. Preliminary results in the validation of a novel short term test. Mutation Research 46:305-310.
Hjørnevik L (1997). Characterisation of handling and storage|properties of Formi LHS-S. Recommendations rearding type of|silicate and bagging quality to be used in production.|Project No. R74632.200, Research Centre Porsgrunn.
Method: other: subacute study by inhalation with the dynamic method in 800 l chambers
Method: other: specific investigation of particle deposition in airways
Goodyear (1973) Toxicity data of rubber chemicals. Letter|from Widmer H, August 8, 1973
Hoberg, J.R. (2002). Aminosilane - Toxicity to the|Freshwater Green Alga, Pseudokirchneriella subcapitata. |Springborn Smithers Laboratories, Wareham, MA. Report No.|12023.6132.
Chemicals Evaluation and Research Institute (CERI), Japan|(1998). Unpublished report
Culler, Bitman, Thompson (1979): J. Dairy Sci. 62, 584-595
Best EPH, Miller JL, and Larson SL (1999). Explosives|removal from groundwater at the Volunteer Army Ammunition|Plant, TN, in small-scale wetland modules. In: Means JL and|Hinchee RE (eds.). Wetlands and Remediation, an|International Conference, Salt Lake City, UT, Nov. 16-17,|1999, 365-373. Battelle Press, Columbus, Ohio.
Method: other: Incubation in wetland mesocosms under field conditions
Jacobson-Kram D and Sigler CI (1991). CHO/HGPRT Mutation Assay with Confirmation - 4,4'-dichlorodiphenyl sulphone. Microbiological Associates Inc., Laboratory Study No. T9359.332001.
Bushy Run Research Center (1986) Hexamethyldisilazane |(A-166) Acute Inhalation Toxicity Test. Project report |49-93, August 6, 1986.
Clemens, H.P. and Sneed, K.E. (1959) Lethal Doses of Several|Commercial Chemicals for Fingerling Channel Catfish. US Fish|Wildl Serv Sci Rep Fish No 316, USDI, Washington, DC:10;|Reference Number: 934
Chemical Industry Institute of Toxicology. Final report on|a chronic inhalation toxicology study in rats and mice|exposed to methyl chloride. Unpublished study prepared by|Battelle-Columbus Laboratories, Columbus, OH. OTS Submission|Document ID 40-8120717. Microfiche No. 511310. (1981).
Repeated dose toxicity: dermal, IUC4#180/Ch.5.4
Bayer AG (1996). IPDI (Isophorondiisocyanat), evaluation of respiratory sensitization in guinea-pigs following intradermal induction. Report No. 24967, 1458 pp., also on NTIS/OTS Microfiche 0558691, Doc 86-960000490 (1996).
Method: other: exposure criteria of OECD Guideline 403 (1981) and Directive 84/449/EEC, B.6 fulfilled
2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-octyl-7-oxo-8-oxa-3, 5-dithia-4-stannatetradecanoate (IUC4 DSN 33)
Genetic toxicity in vitro, IUC4#161/Ch.5.5
Method: other: Concept-standards NEN 6501, 6502, 6504 and 6506 (1 to 4) of Dutch Institute of Normalization
Ragot J, Voetz M , Product Stewardship Baytubes
Hofstetter TB, Heijman CG, Haderlein SB, Holliger C,|Schwarzenbach RP (1999) Complete reduction of TNT and other|(poly)nitroaromatic compounds under iron-reducing subsurface|conditions. Environ Sci Technol 33 (9): 1479 - 1487
Rothe A (1976). Zur Frage arbeitsbedingter Hautschädigungen durch Polyurethanchemikalien. Berufsderm. 24, 7-24.
Kramer CR, Truemper L (1986) Quantitative Struktur-Aktivitats-beziehungen fur die Hemmung des autotrphen Wachstums synchroner Chlorella vulgaris-suspensionen durch monosubstituierte Phenole. Biochemie und Physiologie der Pflanzen 181:81-89.
Palmatier RN et al. (1997): Induction and prevention of|squamous transformation of bronchial epithelial cells by|phenolic compounds. Xenobiotica 27(12), 1201-1214
BASF AG, Safety data sheet CAFFEINE ANHYDROUS FINE POWDER|1A001BG2, 25.10.2001
FMC corporation, Acute oral toxicity, Study no. I2001-2331|(unaudited report), 2001.
Bayer AG (2002). Performance Chemicals Business Group,|Technical Information Bull. Phosphorus Trichloride.|2002-08-05.
Velsicol Chem. Corp. (1981) Benzotrichloride - four-week|subacute inhalation toxicity study in rats with amendment.|26 May 1981. As submitted to U.S. EPA under TSCA on 25|August 1981, U.S. EPA TSCA FYI-OTS-0000122-0 IN.
Rakieten N. et al. (1971). Proc. Soc exp. Biol. Med. 137,280.
Amberger, V. and Vilsmeier, K. (1979). Z. Pflanzenernaehr.|Bodenkd. 142, 778-785.
Pettitt G, Bains G, Dutton T (2001). Modelling of indoor|releases of water reactive toxic materials. Symposium Ser.|148, 405-413.
Zahn R and Wellens H (1980). Prüfung der biologischen|Abbaubarkeit im Standversuch - weitere Erfahrungen und neue|Einsatzmöglichkeiten. Zeitschrift fuer Wasser- und Abwasser|Forsch. 13(1), 1-7.
Method: other: according to later OECD Guide-line 302 B
Safepharm Laboratories Ltd.(2002), N-tert-butylbenzothiazole-2-sulphenamide: Vapour pressure, Report No. 1723/001
IBR (International Bio-Research) (1983). 3-Isocyanatomethyl-3.5.5-trimethylcyclohexylisocyanat - Prüfung auf sensibilisierende Eigenschaften am Meerschweinchen nach B. Magnusson und A.M. Kligman (gemäß OECD Richtlinien). Report 2-5-120-83 (Hüls AG, unpublished).
As cited in IUCLID database, no primacy reference is|available
Method: other: incubation time: 4 hours; determination of ß-galactosidase activity
Sekihashi K, Yamamoto A, Matsumura Y, Ueno S,|Watanabe-Akanuma M, Kassie F, Knasmüller S, Tsuda S, Sasaki|YF (2002) Comparative investigation of multiple organs of|mice and rats in the comet assay. Mut Res 517: 53-75
Genetic toxicity in vivo, IUC4#31/Ch.5.6
Huntingdon Life Sciences Ltd. (1999). Tungsten carbide|powder - Pure. Skin sensitization to the Guinea-pig.|Unpublished Report No. ITU 018/983092/SS, April 1, 1999.
GESTIS - Substance Database (Information system on hazardous|substances of the Berufsgenossenschaften), 12.10.2005
Kemp, R. and Keegan, S.E. (1985) Calcium chloride. In|Ullmann's Encyclopedia of Industrial Chemistry, 5th|completely revised ed. (Gerhartz, W., exec. ed.), VCH|Publishers, Vol. A4, pp. 547-553.
Skin irritation / corrosion, IUC4#21/Ch.5.2.1
ABCR GmbH & Co. 2001. Data Sheet. SND3320. http://www.abcr.de/cgi-bin/db2www.exe/abcr_en.mac/datenblatt?TNR=SND3320 (accessed May 18, 2001).
Tremain, S.P. 2004. Tetrabutyltin (CAS No. 1461-25-2): Determination of Vapour Pressure. SafePharm Laboratories, Derbyshire, U.K. SPL Project Number: 445/449.
EPA OTS 797.1300 (Aquatic Invertebrate Acute Toxicity Test, Freshwater Daphnids)
NTP (1980) Annual Plan for Fiscal Year 1981, NTP-80-62: 37
Jacobs GA (1992). OECD Eye Irritation Tests on Allyl Alcohol|and Dimethylsuphoxide, Journal of the American College of|Toxicology 11, 729
Abbott Laboratories (1978). Medical Safety Data Sheet -|Dicyclohexylamine. Abbott Laboratories, Chemical and|Agricultural Products Division Chicago, Illinois.
Degussa AG, unpublished, Report: Degussa AG - US-IT-Nr.:|79-0016-DKT (1979)
Long-term toxicity to aquatic invertebrates, IUC4#100/Ch.4.5.2
Nishino SF, Spain JC (2001). Identification of bottlenecks|to the in situ bioremediation of dinitrotoluene. In: Magar|VS, von Fahnestock FM, Leeson A (eds.). 6th International In|Situ and On-Site Bioremediation Symposium, San Diego, CA,|United States, June 4-7, 2001, Volume 3, 59-66. Battelle|Press, Columbus, Ohio.
Salmonella typhimurium TA 98, TA100, TA 1535, TA 1538
Pamukcu, A.M., Yalciner, S. and Bryan, G.T. (1977)|Inhibition of carcinogenic effect of bracken fern (Pteridium|aquilinum) by various chemicals. Cancer, 40, 2450-2454.
Huls (1994) Determination of the effects of|Isobutyltriethoxysilane (Dynasylan IBTEO) on the swimming|behavior of Daphnia magna STRAUS (as specified by 84/449 EC,|Nov. 1989). Final Report DK 496. Degussa AG-US-IT-Nr.:|94-0269-DGO January 14, 1994
Fraunhofer Institute of Toxicology (1992) Dynasylan IBTEO:|Cytogenetic tests for the analysis of chromosomal|aberrations in cultured mammalian cells. Report 91/6 CM|Degussa-Huls AG-Nr.: 92-0269-DGM April 7, 1992
Frantz SW. 1987. Hexyl CARBITOL (R): Nine-day repeated dose|percutaneous toxicity study in albino rabbits. Bushy Run|Research Center, Union Carbide Corporation, Report Dated May|29, 1987.
Bayer AG (1976). Acute Fish Toxicity of Benzotrichloride.|Unpublished Report, written 2001-03-29.
CIT (2004) Prenatal Development study by oral route (gavage) in rats. Study number 26889 RSR, Evreux, France. Study sponsor: L'Oreal.
Method: other: Heddle, J.A.: in: Stich, H.F. and San, R.H.C. (eds): Short Term Tests for Chemical Carcinogens, Berlin, Springer, 250-254, (1981)
Dolgov, B., V. Davydova, and M. Voronkov. 1957. Zh.|Obshch. Khim. (Journal of General Chemistry) 27(6):1593.
Takahashi, M. et al. (1986): Cancer Lett. 30, 161 - 168
Method: other: Gastric Tumour Promotion Assay
Salmonella typhimurium TA98, TA100, TA 535, TA1537, TA1538
Communication between the ICCA Consortium members, 05/2004
JETOC (Japan Chemical Industry, Ecology-Toxicology and|Information Center) Newsletter, vol. 3, 11 - 13 (1984).
Kimmerle G (1976). Akute Inhalationstoxizität von Diisocyananaten, polymeren Isocyanaten und Lacksystemen an Ratten. Report No. 6200 (unpublished). Bayer AG (Wuppertal).
Brühl JW (1894). Studien über Tautomerie. Journal fuer|Praktische Chemie/Chemiker-Zeitung 2 (50) 119-221.
Method: other: according to Draize Pharmacol. Exper.Therap. 82, 377 (1944)
Elmore E and Fitzgerald MP (1990). Evaluation of the|bioluminescence assays as screens for genotoxic chemicals.|Mutat. Environ. D 1990, 379-387.
SafePharm Laboratories (2007)|Vinyltris(methylethylketoximino)silane (CAS No. 2224-33-1):|Determination of Vapour Pressure. SPL Project Number|2383/0010.
Bemis, A.G., Dindorf, J.A., Horwood, B., Samans, C. 1982. |Phthalic acids and other benzenpolycarboxylic acids. IN: |Kirk-Othmer encycl. Chem. Tech. 3rd Ed. 17: 732-77.
Amer SM and Ali EM (1969): Cytological effects of|pesticides. IV: Mitotic effects of some phenols. Cytologia|34, 533-540 as cited in: Dean BJ (1978): Genetic toxicology|of Benzene, Toluene, Xylene and Phenols. Mutation Research|47, 75-97
BASF AG (1989). Department of Toxicoloy, unpublished fish|acute toxicity study, unpublished report No. 88/218,|30 March 1989.
Method: other: closely following German Industrial Standard DIN 38 412, Part 15
Fiss J (1976). Diss. Akademie für ärztl. Fortbildung der DDR, Berlin. Cited in: Ziegler V and Süss E (1985): The TINA test. Curr. Probl. Derm. 14, 172-192.
Method: other: A modification of the method described by Polak & Turk, Clin. exp. Immunol. 7., 739 - 744 (1970), during the induction exposure the testsubstance is applied in 3 different ways (i.m.; i.d. and epicutaneously)
Oldersma, H., A.O. Hanstveit, and J.M. de Wolf. 2003. 1,3,2-Dioxastannepin-4,7-dione, 2,2-dibutyl- (DBTM) (CAS# 78-04-6): Determination of the effect on the growth of the fresh water green alga Scenedesmus subspicatus. TNO Report No. V4017/05. October 2003.
Keil W. et al.: Arzneimittelforschung 4, 477-479, (1954);|cited in: BG Chemie, Datenkatalog Nr. 205
BASF (1964) Skin sensitization in guinea pigs (XIV/97;|XIV/182-183). BASF AG, Department of Toxicology, 15.09.1964|(unpublished data)
CIT (1994) Skin sensitization test in guinea-pigs with|2-ethylhexyl thioglycolate, CIT study no. 10268 TSG, 14|February 1994.
CIT (1993) Acute eye irritation in rabbits with 2-ethylhexyl thioglycolate, CIT study no. 10267 TAL, 30 december 1993.
Method: other: comparable to OECD-Guideline 203 (Fish: Acute Toxicity Test, 1992)
Hawley GG (1977) The Condensed Chemical Dictionary (9th ed)|Van Nostrand Reinhold Company, New York, p 672
Degussa-Huls AG (1995) Determination of the acute toxicity|of DYNASYLAN ATAC In earthworms (Eisenia foetida foetida)|(In accordance with Toxicology test for earthworms 88/302|EWG). Final Report. RW 061. Degussa AG-US-IT-NR. 95 0223|DGO. 12/11/95.
EU Method C.8 (Toxicity for Earthworms: Artificial Soil Test)
Toxicity to microorganisms, IUC4#140/Ch.4.4
Kavlock, R.J., Short, R.D., Jr., and Chernoff, N. (1987)|Further evaluation of an in vivo teratology screen. Teratog.|Carcinog. Mutagen. 7:7-16. Cited in BIBRA (1993)
Nyholm, N. and Kristensen, P. Ecotox. Environ. Safety |23:161-172 (1992)
Malley LA, Kennedy GL, Elliott GS, Slone TW, Mellert W,|Deckardt K, Gembardt C, Hildebrand B, Parod RJ, McCarthy TJ, Griffiths JC (1999) 90-dag subchronic toxicity studies in rats and mice fed N-Methylpyrrolidone (NMP) including|neurotoxicity evaluation in rats. Drug Chem Toxicol, 22,|455-480
Method: other: Directive 87/302/EEC, part B, OECD guide-line 408, TSCA test guideline §40 CFR 798.2650
Martin H and Maris P (2005). An assessment of the|bactericidal and fungicidal efficacy of seventeen mineral|and organic acids on bacterial and fungal food industry|contaminants. Sciences des Aliments 25, 105-127.
Method: other: microdilution method of Martin & Maris (1993)
Elliott ML and Des Jardin EA: Effect of organic nitrogen|fertilizers on microbial populations associated with|bermudagrass putting greens. Biol Fertil Soils 28, 431-435|(1999)
Waggy, G.T. and Payne, J.R. (1974), "Environmental Impact|Product Analysis Acute Aquatic Toxicity Testing", Research|and Development Department, Chemicals and Plastics Union|Carbide Corporation, South Charleston, West Virginia, Report|No. 910F44
Verschueren, Karel, handbook of Environmental Data on|Organic Chemicals, Vol. 2, 4th ed. Van Nostrand Reinhold,|New York (1996).
Hüls AG (1989). Laurinlactam - determination of the|biodegradability in the BOD Test for insoluble substances|(BLOK-Test). Report No. 89/22 (unpublished)
Method: other: BODIS Test (ISO 10708, in preparation)
Chapman, A.H. 1981. Unpublished work. Int. Tin Res. Inst. Perivale, Middx. IN The Handbook of Environmental Chemistry. 1990. O. Hutzinger (ed.). Vol. 3, Part E. Anthropogenic Compounds. Springer-Verlag. Berlin, Germany.
Sasaki M., Yoshida, S. and Hiraga K. Additional effect of acetaminophen on the mutagenicity and clastogenicity of N-methyl-N' -nitro-N-nitrosoguanidine in cultured Chinese hamster CHO-Kl cells. Mutation Research. 122, 367-372, 1983
Battelle Europe. 1991. Study on the 'Ready|Biodegradability' (modified Sturm Test) of Isophthalic Acid.| Study-No: BE-EA-128-91-01-STT-02.
Method: other: OECD Guide-line 301 B and Directive 79/831/EEC Annex V
TNO (1982) Examination of Butanox M-50 for Mutagenic|Activity in the Ames Test. CIVO Institutes TNO. STUDY #: V|82.094/220064; Project No. B 82-0064/3. Study Date: March,|1982.
EA Japan (Environmental Agency, Japan) (1999c). Acute|aquatic toxicity of dicyclohexylamine on Selenastrum|capricornutum. MOE (Ministry of the Environment, Japan)|unpublished data.
Inge-Vechtomov, S.G. et al., Prog. Mutat. Res. 5, 243-255|(1985)
Portmann, J.E. and K.W. Wilson (1971) The Toxicity of 140|Substances to the Brown Shrimp and Other Marine Animals.|Shellfish Information Leaflet No 22 (2nd Ed), Ministry of|Agric Fish Food, Fish Lab Burnham-on-Crouch, Essex, and Fish|Exp Station Conway, North Wales: 12; Reference Number: 906.
Genetic toxicity in vivo, IUC4#158/Ch.5.6
Flavor and Extract Manufacturers Association (FEMA) (1979) Scientific Literature Review of Phenols in Flavor Usage. Volume 1 (as cited in Liebert (1986).
S. typhimurium TA100, TA1535, TA98, TA1537
Li, A.A., Kaempfe, T.A., O'Donnell, P.E., Smolboski, D. 1994. Acute Neurotoxicity Study of Isobutanol in Sprague-Dawley Rats. Monsanto Project No. EHL 94009 and Union Carbide Laboratory Project No. 37-AEG-131.
Monsanto Study SA-85, Dec 1954, Scientific Associates Lab. as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Bringmann G (1975). Bestimmung der biologischen Schadwirkung|wassergefaehrdender Stoffe aus der Hemmungder Zellvermehrung|der Blaualge Microcystis. Gesundheitsingenieur 96 (9),|238-241.
Anders, M.W. and Dekant, W.: In: Renal Disposition and|Nephrotoxicity of Xenobiotics, pp. 155-183 (1993), as cited|in Dekant 1995.
BASF AG, (1977) Report on the study of n-Butylacrylat in the Ames Test.Dept. of Toxicology, unpublished study, (77/240), 07-27-1977
Method: other: Ames, B.N. et al.: Mutation Research 31, 347-364, 1975
US Environmental Protection Agency AQUIRE database.
Industrial Biology Laboratories Inc, Shelanski MV (1964 d)|Schwartz patch test. Study report Project No. SH-64-6.|Unpublished study of Monsanto Chemical Co
BASF AG, Product Safety, beta-Ionon R - Subchronic toxicity|study in Wistar rats, administration in the diet for 3|months, unpublished report, project no. 50S0449/02057,|02/449-1, 04 June 2004
RCC. 2001. Acute Dermal Toxicity Study in Rats. Mark 17 M. RCC Study Number 785687. 21.06.2001.
Papa, C.M. and Shelley, W.B. (1964), Menthol|Hypersensitivity, J. Am. Med. Ass. 189, 546-548 (100-102)
Johnson W, Swanson K (1987). Final report on the safety|assessment of sodium sesquicarbonate, sodium bicarbonate and|sodium carbonate. J. Am. College Toxicol., 6, 121-138.
reduction of the maximum density (yield)
The Merck Index (1983) The Merck Index (10th Ed.), 1176.
Murray SA (1979) Periphyton responses to chlorination and|temperature. Environ Impact Health Eff., Vol 3, Ann Arbor|Sci. Publ., MI, 641-647
Furihata, C. et al.: Jpn. J. Cancer Res. 79, 917-920 (1988), No information
HCFC 124 in gaseous phase: assessment of mutagenic potential|in amino-acid auxotrophs of salmonella typhimurium and|Escherichia Coli (The Ames Test), Life Science Research Ltd,|Eye, Suffolk, England, LSR Report No. 91/PAR001/0842,|December 1991. Study performed for PAFT III Group.
Method: other: OECD Guide-line 471 and 472, and EPA OTS 798.5265.
Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, Escherichia coli WP2 uvrA
SafePharm Laboratories (2002) SPL Project number 1254/039.|IOTG: Determination of vapour pressure. 2002.
Method: P06-04:Method A4 specified in Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC).
Test secies/strain:Salmonella typhimurium TA100, TA1535, TA98, TA1537, Escherichia coli WP2 urvA
Bayer AG (1990). Information Card for Dicyclohexylamine.
Method: other: cell multiplication inhibition test acc. to Bringmann, G.; Kuehn, R.: WAF 10, 87-98 (1977)
Degussa AG (2004), unpublished report. Estimation of the|Partition coefficient (n-Octanol/Water) of Diethyl malonate|CAS-No.: 105-53-3 by Quantitative Structure Activity|Relationship (QSAR-Method = Calculation). |Degussa AG-Reg-Nr.: 2004-0180-DKB.
Method: other (calculated): KOWWIN (LOGKOW (c)) Program, Version 1.67, Syracuse Research Corporation, Merrill Lane, Syracuse, New York, 13210, U.S.A.
Paschoud, J.-M. (1963), Quelques cas d'eczéma de contact|avec sensibilisation de groupe, Dermatologica 127, 349-364
Oldersma, H., A.O. Hanstveit, and J.M. de Wolf. 2003. Dibutyldichlorostannane (CAS# 683-18-1): Determination of the effect on the growth of the fresh water green alga Scenedesmus subspicatus. TNO Report No. V2495/04. October 2003.
Atochem, 1987. Fumyl-o-gas. Fiche de données de sécurité.|Paris, Groupe Elf Aquitaine, 4 pp.
Huntingdon Research Centre (1978). IPDI and TMDI - acute inhalation toxicity, Report VBC 1/78994, Veba-Chemie AG (Gelsenkirchen, Germany, unpublished).
Method: other: according to Cole et al. 1979
CIBA-GEIGY Ltd. 1993. Report on the test for ready biodegradability in the Modified Sturm Test of Irgastab 17M. Test No.: 928310. Basel, Switzerland. 14/04/93.
Method: other: DNA Polymerase Deficient Assay, liquid suspension assay see freetext ME
Itami T, Ema M, Kawasaki H, Kanoh S (1989) Evaluation on|teratogenic potential of sodium sulfite in rats. Drug Chem|Toxicol 12: 123-135
Lomonova, G.V., Gig. Tr. Prof. Zabol. 10, 54-57 (1966),|zitiert nach: IARC Monographs on the Evaluation of the|Carcinogenic Risk of Chemicals to Humans, Vol. 39,|International Agency for Re- search on Cancer, Lyon, 247-275|(1986)
Furukawa A, Ohuchida A (1990) In vitro micronucleus tests of|polyploid inducers. EEMS Meeting 1990, Book of Abstracts:|P146
Anderson B.E. et al., Environm. Molec. Mutagen. 16 [Suppl|18] 55-137 (1990)
Method: other: similar to OECD 473; Galloway S.M. et al., Environ. Mutagen. 7, 1-52 (1985)
Hoechst AG (1989): Unpublished study: Subakute orale|Toxizität (28 Applikationen in 29 Tagen) an|SPF-Wistar-Ratten (Ber.-Nr. 89.1128), 3 Aug 1989
Method: other: OECD Guideline 407 (1981)
National Toxicology Program, 2-Chloronitrobenzene|Reproduction and Fertility Assessment in Swiss CD-1|mice when administered via gavage, Final Report,|April, 1992
Method: other: 8 mice/sex/dose, statistical analysis
Anonymous (2003): Final report on the safety assessment of|sodium sulfite, potassium sulfite, ammonium sulfite, sodium|bisulfite, ammonium bisulfite, sodium metabisulfite, and|potassium metabisulfite. Int. J. Toxicol. 22 Suppl 2, 63-88
Method: T09-02:occlusive 24 hour exposure to undiluted test substance
Jacóbczyk, J. et al., Untersuchung der biologischen|Zersetzung aromatischer Nitroverbindungen in Abwaessern,|Chem. Techn. 36, 112 - 116 (1984)
Method: other: degradation in activated sludge reactor or in semi-immersed rotating disc reactor
Moerman, D.G. and Baillie, D.L.: Mutat. Res. 80, 273-279|(1981), No information
CRC Handbook of Chemistry and Physics. 1991-1992. D.R. Lide |(ed.) 72nd ed. CRC Press, Inc. Boca Raton, FL. P.3-155.
INBIFO Report, No. Ao384/1623. Sponsored by Rohm GmbH|(micronucleus test) (1979)
David, R.M., Tyler, T.R., Ouellette, R.E., Faber, W.D.,|Banton, M.I., Garman, R.H., Gill, M.W., and O'Donoghue, J.L.|Evaluation Of Subchronic Neurotoxicity Of N-Butyl Acetate|Vapor. NeuroToxicology 19: 809-822, 1998.
TNO Central Institute for Nutrition and Food Research. 1978. Subchronic (90-day) Oral Toxicity Study with 1175-114 in Rats. Report No. R 5873. Study conducted for Cincinnati Milacron Chemicals, Inc.
USEPA (2000) SAR Model KOWWIN® (version 1.66).
Loprieno N, Boncristiani G, Forster R, Goldstein B (1985)|Assays for forward mutation in Schizosaccharomyces pombe|strain P1. Prog Mut Res 5: 297-306
Method: other: Loprieno, N. (1981): Prog. Mutt. Res. 1, 424,433
CIBA-GEIGY Ltd. 1982. GU2 Toxicology. Report TK 10422. Acute Oral LD50 in the Rat. GU Project No. 811808. Basle, Switzerland. 01.02.1982.
Gomólka B and Gomólka E (1981). The Effect of|N-Methylpyrrolidone (NMP) on the Action of Activated Sludge.|Acta hydrochim. hydrobiol. 9, 555-572.
Method: other: different methods according to Polish standard protocols
Deutsche Forschungsgemeinschaft (1985): Toxikologisch-|arbeitsmedizinische Begruendung von MAK-Werten - Butyl-|hydroxytoluol (BHT), VCH Weinheim
Genetic toxicity in vitro, IUC4#256/Ch.5.5
Daubert TE and Danner RP (1989). Physical and Thermodynamic|Properties of Pure Chemicals Data Compilation. Taylor and|Francis, Washington DC.
Method: other (calculated): with KOWWIN v. 1.67, 2000
BASF AG: Department of Toxicology, unpublished data, Report on the study of the primary irritation to the eye of rabbits, (XII/248), October 04, 1962
Schultz TW, Seward JR (2000). Dimyristoyl|phosphatidylcholine/water partitioning-dependent modeling of|narcotic toxicity to Tetrahymena pyriformis. Quantitative|Structure-Activity Relationships 19 (4), 339-344.
Bayer AG 1986b, Internal study: Test on water solubility|(1986.04.09)
Tracor-Jitco, Inc. (1974) Scientific Literature Reviews on|Generally Recognized as Safe (GRAS) Food Ingredients, Acetic|Acid and Acetates. Prepared for FDA. NTIS PB-234 898. Cited|in United States Environmental Protection Agency (1991)
Method: other: method of Ames, McCann, Yamasaki
Holwerda, D.A. and H.J. Herwig. 1986. Accumulation and Metabolic Effects of Di-n-Butyltin Dichloride in the Freshwater Clam, Anodonta anatina. Bull. Environ. Contam. Toxicol. 36:756-762.
Long-term toxicity to aquatic invertebrates, IUC4#9/Ch.4.5.2
Kennelly, JC (1988)Degussa-Huls AG (1988). #: 88-0299-FGM|Study to determine the ability of nineteen compounds to|induce mutation in three Histidine-requiring strains of|Salmonella typhimurium.
Frei, J.V. and Venitt, S.: Mutat. Res. 29, 89-96 (1975)
Yoshioka Y, Nagase H, Ose Y, Sato T (1986) Evaluation of the|Test Method "Activated Sludge, Respiration Inhibition Test"|Proposed by the OECD. Ecotoxicol Environ Safety 12: 206 -|212
Stom DI, Roth R (1981) Some effects of polyphenols on aquatic plants: 1. Toxicity of phenols in aquatic plants. Bulletin of Environmental Contamination and Toxicology 27:332-337.
Method: other: In-house method see remarks
Palm P.E. et al.: Toxicol. Appl. Pharmacol. 44, 1-16, (1978)
Developmental toxicity / teratogenicity, IUC4#32/Ch.5.8.2
Draft Workplace Environmental Exposure Level Guide, Glycidyl Methacrylate (1999)
SRC-PCKOCWIN v1.66, Calculation of KOC (2000)
Method: other (calculation): SCR-PCKOCWIN v1.66
Rinehart, WE, Acute Oral Toxicity Study in Rats,|Toxicological Resources Unit, Bio/dynamics Inc., May 15,|1978.
Phototransformation in air, IUC4#15/Ch.3.1.1
Hoechst AG (1993) Nitro-o-dichlor-benzol asymmetrisch,|Testing for subacute oral toxicity (28 applications within|29 days) in male and female Wistar rats (unpublished report|no. 93.0290). Hoechst AG, Frankfurt
Marhold JV (1972) Sbornik Vysledku Toxikologickeho Vysetreni|Latek A Pripravku. Inst. pro vychovu vedoucich pracovniku|chemickeho prumyslu, Praha: 94
Bewley, R.J.F. & Parkinson, D. (1984): Effects of sulfur|dioxide pollution on forest soil microorganisms. Can. J.|Microbiol. 30(2), 179-185
Hansch C, Leo A, Hoekman D (1995). Exploring QSAR|Hydrophobic, Electronic and Steric Constants 14, 201. In|Heller S ed. ACS Professional Reference Book, American|Chemical Society, Washington DC.
Daubert TE and Danner RP (1989): PHYSICAL AND THERMODYNAMIC|PROPERTIES OF PURE CHEMICALS: DATA COMPILATION.; DESIGN|INSTITUTE FOR PHYSICAL PROPERTY DATA, AMERICAN INSTITUTE OF|CHEMICAL ENGINEERS. HEMISPHERE PUB. CORP., NEW YORK, NY., 4|VOL.
Umweltbundesamt (1992): Unveroeffentlichte Untersuchung
Lubek BM et al. (1989): Cataractogenicity and bioactivation|of naphthalene derivatives in lens culture and in vivo. Lens|Eye Toxic Res 6, 203-209
Tyler, T.R., Ivett, J.L., and R.R. Young
EPA OPPTS 870.5395 (In Vivo Mammalian Cytogenics Tests: Erythrocyte Micronucleus Assay)
Ciba Speciality Chemicals Inc (1989). RCC Project 247825.|Contact hypersensitivity to FAT 65´019/H in albino guinea|pigs. Maximisation-test. Study reported from RCC to|Ciba-Geigy AG dated 1989-11-20.
Method: other: Calculated using EPISUITE v.3.10 and BCFWIN v.2.14 with a log Kow of 0.88.
Gardner,E.P. et al., J. Phys. Chem. 88, 5069-5076, 1984, No information
Yoshioka Y, Ose Y, and Sato T (1985). Testing for the|toxicity of chemicals with Tetrahymena pyriformis. Sci.|Total Environ. 43, 149-157.
Chemicals Evaluation and Research Institute (CERI), Japan.|Product data sheet. AOPWIN v1.90, 31.07.2003.
Liu J and Lang P (2000). Effect of monotoxicity and|mixtoxicity of nitroaromatics to the algae, Scenedesmus|obliquus. J. Environ. Sci. 12 (3), 367-368.
Curtis C, Lima A., Lozano S.J. and G.D. Veith, 1982,|Evaluation of a bacterial bioluminescence bioassay as a|method for predicting acute toxicity of organic chemicals to|fish, ASTM STP 766, American for Testing and Materials,|Philadelphia, pp 170-178
Monsanto study MO-77-615. Biodegradation of Phosphate Esters. (1977)
Method: other: Method similar to OECD 302-A
Lewis, R. and Tatken, R.C. in: "Registry of Toxic Effects of|Chemical Substances"; Cincinnati, Ohio, National Institute|for Occupational Safety and Health, Vol. 1, 695 (1980);|cited in: IPCS Environ. Health Crit. 89, (1989), No information
Kapias T, Griffiths RF (2001). Spill behaviour using|REACTPOOL part III. Results for accidental releases of|phosphorus trichloride and oxychloride and general|discussion. J. Hazardous Materials A81, 223-249.
LewisRJ(1996). Sax's Dangerous Properties of Industrial|Materials. 9th ed. Vol.3, Van Nostrand Reinhold, 3108-3109.
Method: other: according to a dutch national standard method: NEN 6502, 1980 (Wateronderzoek. Bepaling van de chronische toxiciteit met Daphnia magna)
Method: other: Internal Union Carbide method for dermal toxicity. Thompson's method of calculating the LD50 was used.
Galloway SM, Armstrong M, Reuben C, Colman S, Brown B (1983)|In vitro cytogenetic tests by a standard protocol: results|for aberrations and SCEe on 56 compounds, and comparison|with carcinogenicity data. Environ Mutagen 5: 403 [abstract]
Method: other: Galloway, Environ. Mutagen.7,1-51 (1985) see also freetext Method
Hoechst AG (1993): Interne Berechnung vom 07.05.1993
Melnikov J, Keeffe JR, Bernstein RL (1981) Carcinogens and|Mutagens in the Undergraduate Laboratry. J Chem Educ 58:|A11-A14
Method: other: according to Ames et al., Mutat. Res. 31,347 (1975)
Method: other: anaerobic degradation, static, analytical control of concentration
Ryter and Dodin (1988): Ultrastructural alternations caused|by antiseptics against various bacterial strains. Bull Soc.|Path. Ex., 81, 811-818.
TSCAT (1982) OTS84003A, New DOC I.D. 878212113, 10-01-1982,|SHELL Oil Co. Study report: Test standardisation: Inhalation|toxicity testing of 8 chemicals according to the OECD|Inhalation Hazard Test. Unpublished study report Nr.|SBGR.82.341 of the SHELL Toxicology Laboratory dated October|1982, with accompanying letter dated April 18, 1983.
Melhem GA, Reid D (1998). A detailed reaction study of|phosphorus trichloride and water. Process Safety Progress,|17 (1), 49-60.
Takahashi A, Ono H (1993). Mutagenicity assessment in 44|epoxy resin hardeners in Salmonella typhimurium tester|strains. Chemistry Express 8, 785-788.
Method: other: Method of Ames et al. (1975) as modified by Yahagi et al. (1977), Mutat Res. 48, 121
Epstein WL (1981): Report on human maximisation studies.|Report to RIFM, unpublished. RIFM-FEMA Database, location|1792.
Hemminki, K. et al.: Arch. Toxicol. 46, 277-285 (1980), No information
Genetic toxicity in vitro, IUC4#267/Ch.5.5
Ciba-Geigy Ltd., Report on acute oral LD50 in the rat of TK|10044, Project No. 811493, 2.12.1981.
Genetic toxicity in vitro, IUC4#284/Ch.5.5
Oishi et al.; Toxicology Lett. 13, 29-34 (1982)
Ritter A (1990) FAT 65'023/L: Acute Toxicity of FAT 65'023/L|to Scendesmus Subspicatus. RCC Umweltchemie Itingen|(Switzerland)
Shelby M (1990). Results of NTP-sponsored mouse cytogenetic|studies on 1,3-butadiene, isoprene and chloroprene, Environ.|Health Perspect., Vol. 86, pp. 71-73.
Budavari S., O’Neil M., Smith A., Heckelman P., Kinneary J.
BASF AG, Department of Ecology, unpublished calculation,|09.01.1989
Applegate VC, Howell JH, Hall AE, Smith MA (1957) Toxicity of 4,346 Chemicals to Larval Lampreys and Fishes. Spec Sci Rep Fish No 207, Fish Wildl Serv, USDI, Washington, DC: 157 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Calculation of the OH Rate Constant with SRC-AOP v1.90
Degussa-Huls AG (1994) Determination of the |biodegradability of DYNASYLAN HMDS in a closed |bottle test (in accordance with EEC 92/69 C4-E).|Final Report GF-223. Degussa-Huls AG-US-IT-NR. |93-0207-DGO 01/11/94.
Syracuse Research Corporation (SRC) (2000). Online database.
Method: other (calculated): according to Environmental Science, Syracuse Research Corporation (SRC) database, USA.
Method: other: comparable to OECD guideline 479
Syamsiah S, Krol A, Sly L, and Bell P (1993). Adsorption and microbial degradation of organic compounds in oil shale|retort water. Fuel 72(6), 855-861.
Method: other: GC-MS analysis of the RWTC influent and effluent
Goldman M (1981) Experentia 37, 1348. Cited in BIBRA (1993)
Allied Corporation (1979) Evaluation of|[3-Glycidoxypropyltrimethoxysilane] for|Mammalian Cell Mutagenicity in Chinese Hamster Ovary (CHO)|Cells (Allied Corporation, Project no. MA-52A).
Ministry of Environment (MOE), Korea(2001), The toxicity of Acetanilide to Aquatic plants; algae(tested by KRICT)
Environmental Agency, Japan(1998): unpublished report on|Alga, Growth Inhibition Test (No. 91906)
Schnuch, A. et al., British Journal of Dermatology 138,|467-476 (1998)
BASF AG (1988). Department of Ecology. Modified OECD|Screening Test, study No.52/4849/88, 28 Sep 1988,|unpublished.
Bringmann,G., Kuehn,R., Zeitschrift Wasser Abwasser|Forschung 10(5), 161-166, 1977, No information
Method: other: Mobilization Inhibition Test
BRRC, study report no. 92U1013, (sponsored by Union Carbide|Corporation)
Method: other: Younger Laboratory method
Adema DMM (1982). Tests and desk studies carried out by|MT-TNO during 1980-1981 for annex II of marpol 1973. TNO,|Delft (NL), Report No. CL82/14.
Long-term toxicity to fish, IUC4#4/Ch.4.5.1
Grothe R (1993). Soil adsorption of FAT 65'023/N on three|soils (screening version). RCC Umweltchemie GmbH Rossdorf;|Project ID RCC 288314 from 09.06.1993.
Gulati, D.K. et al.: NTP study (NTP-85-097), NIEHS, Research|Triangle Park, NC (1984);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
MITI, Biodegradation and Bioaccumulation Data of Existing|Chemicals Based on the CSCL Japan, edited by Chemicals|Inspection & Testing Institute Japan, published by Japan|Chemical Industry Ecology-Toxicology & Information Center,|October 1992
Method: other: OECD Guide-line 301 C, 1974
BASF AG, Department of Experimental Toxicology and Ecology,|Subchronic toxicity study in Wistar rats, administration in|drinking water for 3 months, unpublished report (00/274),|project no. 52C0274/00099, 11 April 2002
Howard P, Boethling R, Jarvis W, Meylan W, and Michalenko E|(1991). Handbook of Environmental Degradation Rates. Lewis|Publishers, Inc. Chelsea, MI, USA, pp. 176-177.
Bayer AG (1976). Internal Report no. 76 MB-CB 0032:|Biodegradability of o-toluidine (report written on March|2001).
Method: other: Closed Bottle Test, comparable to OECD TG 301 D
Method: T16-04:Federal Register, vol.50, No.188, part II of 27 September 1985 Section 798.4500 - Primary Eye Irritation
BASF AG, 1988, Analytical Laboratory, data on the partition|coefficient: choline chloride, unpublished data, report No.|124134/03, 29 July 1988
Schlede, E. et al.: Arch. Toxicol. 69 (10), 659-670 (1995);|cited in: RIFM database, location no. 26984
Morton International, Inc. 1996. Ames/Salmonella-E. coli Reverse Mutation Assay on Test Article 1706-151, Methyltin tris(2-ethylhexylthioglycolate). Study performed by Pharmakon USA. Study Number 0301EM01.002.
UNILEVER (1992); Ecotoxicology study report: the acute|toxicity of sodium hypochlorite solution to Daphnia magna
Method: other: calculated value (based on measured data with the dynamic method, similar to OECD TG 103)
Mobil International (1977). Brusick DS. Mutagenicity|evaluation of MCTR 190-77. Litton Bionetics Inc., Edison,|NJ, Report No. 2683, Mobil internal report (unpublished|report).
Hoechst AG (1975) Akute orale Toxizitaet von|Nitro-o-dichlorbenzol-4,1,2 an maennlichen SPF-Wistar-Ratten|(unpublished report no. 499/75). Hoechst AG, Frankfurt
Monsanto Study No. BO-78-222 as cited in European Chemicals Bureau (2000). IUCLID non-confidential dataset, Year 2000 CD-ROM
Genetic toxicity in vitro, IUC4#130/Ch.5.5
Salmonella typhimurium TA 98, TA 100; Escherichia coli WP2uvrA
Beilstein Database. Copyright 1988-2001 Beilstein Institut|zur Foerderung der Chemischen Wissenschaften. CrossFire|Beilstein, licensed by MDL Information Systems GmbH,|research update: 25 May 2004.
Inversk Resarch International(IRI).(1991g), Acute dermal|Toxicity (LD50) test in rats. Report No.8025, Unpublished|report
Method: T09-02:Testing Guideline for Toxicity Studies of Japanese MAFF(28 January 1985)
BASF AG (2006). Department of Product Safety. Recalculation|of the fish LCx values by probit analysis, 04 Oct 2006,|unpublished.
Method: other: undissolved test substance, dose: 50 mg/animal,observation period: 7 d
WHO (1995). Environmental Health Criteria 174: Isophorone.|World Health Organization, Geneva 1995.
Method: other (calculated): Graphical Exposure Modelling System (GEMS)
Aldrich; Handbook Catalog of Fine Chemicals 1966-1997.|Milwakee, WI: Aldrich Chem Co pg 290 (1996)
Steinhoff D and Dycka J. Chronische epikutane Applikation|von Weisstönern bei haarlosen Mäusen. Pharma Report No.|10325, March 9, 1981. Institute of Toxicology, Bayer AG,|Wuppertal, Germany. As cited in: AISE (2004). Human and|Environmental Risk Assessment (HERA) Report on FWA-1. Draft|of October 2004.
Malaney GW (1960). Oxidative abilities of aniline-acclimated|activated sludge. J. Water Pollut. Control Fed. 32 (12),|1300-1311.
Nozawa, Maruyama. (1988): J. Bacteriol. 170, 5778-5784
Method: other: 15 rats/sex and dose group, rat weight: 160-245 g, food and water ad libitum, 5 different dose levels (see remarks), application by gavage, dosing volume not reported, post dose observation period: 1-2 weeks
Meng Z-Q (2001) Micronuclei induced by derivatives of sulfur|dioxide in mouse bone marrow cells in vivo. Toxicology 164:|100
Schneider S, Buesen R; Fabian E, and van Ravenzwaay B (2008)|Natriumformiat (sodium formate) - Prenatal developmental|toxicity study in Himalayan rabbits. Oral administration|(Gavage). BASF SE, Department of Experimental Toxicology and|Ecology. Study No. 40R0123/03089(unpublished), dated|February 06, 2008
NIA, VNCI (1991), "Chemiekaarten", 7e ed. (Nederland).
NIPPON SHOKUBAI CO.,LTD.: unpublished report
Atkinson R (1989). Kinetics and mechanisms of the gas-phase|reactions of the hydroxyl radical with organic compounds. J.|Phys. Chem. Ref. Data, Monograph No. 1.
Hansch, C., Vinoria, A., Silipo, C. and Jow, P.Y.C.: J. Med.|Chem. 18:546-548 (1975).
Epstein, S.S. and Shafner, H.: Nature 219, 385-387 (1968), No information
Crompton GmbH. 2003. Determination of the vapour pressure of dioctyltin dichloride. Study conducted by RCC Ltd. RCC Study Number: 848723. September 19, 2003.
Method: other (measured): OECD Guide-line No. 104, "Vapour Pressure" (1995) and Directive 92/69/EEC, A.4 (1992)
Method: F21-01:calculated PCKOCWIN (v1.66)
Casanova, M. et al.: Fund. Appl. Toxicol. 12, 397-417 (1989), No information
Method: other: in vivo DNA damage - mammals (somatic cells/DNA-protein crosslinks)
Genetic toxicity in vivo, IUC4#170/Ch.5.6
Schultz T.W. and M.T.D. Cronin, Response-surface analyses|for toxicity to Tetrahymena pyriformis: Reactive|carbonyl-containing aliphatic chemicals, J. Chem. Inf.|Comput. Sci. 39, 304-309, 1999
Method: other: 40-h impairment growth assay (TETRATOX)
Lyman, W.J., Reehl, W.F., Rosenblatt, D.H, 1982. Handbook of|Chemical Property Estimation Methods, Environmental Behavior|of Organic Compounds, McGraw-Hill, New York.
Burris et al. (1990) Env toxicol Chem, 9, 69-76
Langauer M. Nucleus anomaly test on somatic interphase|nuclei FAT 65'023 (TINOPAL DMS) Chinese hamster (test for|mutagenic effects on bone marrow cells). Report, October 30,|1974. Toxicology/Pathology, Pharmaceuticals Division,|Ciba-Geigy Ltd., Basel, Switzerland.
Zeiger, E. B. Anderson, S. Haworth, T. Lawlor, K. Mortelmans. Salmonella mutagenicity tests:IV., Results form the testing of 300 chemicals. Env. Mol. Mutag. Vol. 11/12, 1-19, 1988
Harris JC (1990) Rate of hydrolysis. In: Lyman WJ, Reehl WF,|Rosenblatt DH. Handbook of Chemical Property Estimation|Methods. Americ. Chem. Soc., Washington, 7-4 - 7-5
BASF AG, Department of Ecology, unpublished study, Activated Sludge Respiration Inhibition Test, 01/88/0667. January 24, 1992
Method: other: in line with DIN 38412, part 27
CIBA-GEIGY Ltd. Chromosome Studies of Chinese Hamster Ovary Cell Line CCL 61 In Vitro. Test material: TK 11 338 (n-Butyltintrichloride). Test No.: 884025. Genetic Toxicology Department. Basle, Switzerland. September 14, 1988.
Method: other: Mutagenesis Assay by DNA-repair-Deficient E.coli Strains
BASF AG (1987). Department of Toxicology, project|No.10F0185/875070, 04 Nov 1987, unpublished.
Method: E03-05:German Industrial Standard DIN38412 Part 15
Wiebe J., The control of male fertility by|1,2,3-trihydroxypropane (THP;glycerol): rapid arrest of|spermatogenesis without altering libido, acessory organs,|gonadal steroidogenesis, and serum testerone, LH and FSH,|Contraception 29(3): 291-303, 1984 (15).
Toxicity to reproduction, IUC4#12/Ch.5.8.1
Bringmann G, Kühn R (1976) Vergleichende Befunde der|Schadwirkung wassergefährdender Stoffe gegen Bakterien|(Pseudomonas putida) und Blaualgen (Microcystis aeruginosa).|gwf(Gas- und Wasserfach)-wasser/abwasser 117 (9): 410 - 413
Renner, H. W.: Experientia 38, 600 (1982)
Huls (1992) Determination of mutations caused by|DYNASILAN IBTEO in Salmonella/microsome Ames test based on|Ames mutation test under Guideline 84/449/EEC B. 14. Final|Report AM-92/31. Degussa AG-US-IT-Nr.: 92-0231-DKM 11/03/92
Kenaga EE (1980) Predicted Bioconcentration Factors and Soil|Sorption Coefficients of Pesticides and other Chemicals,|Ecotoxicology and Environmental Safety 4, 26-38
CIBA-GEIGY, Ltd. 1988. Report on the Test for Acute Toxicity of TK 11339 to Daphnia magna. Project No. 884109. Basle, Switzerland. 14.03.1988.
RTECS (Registry of Toxic Effects of Chemical Substances - On|line) (1998).
Kuroki, T. & Munakata, K., Prog. Mutat. Res. 5, 543-545|(1985)
Carter, R.O. & Griffith, J.F. (1965): Toxicol. Appl.|Pharmacol. 7, 60-73.
BASF AG (1966) Study on teratogenic effects of choline|chloride in the mouse after oral application. Department of|Toxicology, Report No. XIV/156, 14.10.1966
Melting point/freezing point, IUC4#22/Ch.2.1
CIT (Centre International de Toxicologie) (2001). Lauryl|lactam: prenatal development toxicity study by oral route|(gavage) in rats. CIT (Centre International de Toxicologie),|Evreux (France), Report No. 20869 RSR
BASF AG, Verfahrenstechnik, unpublished results, report|172.524.1, 29.11.1972
Method: other (measured): dynamic (internal BASF standard)
ACD (= Advanced Chemistry Development) © 1994-2004, Software|Solaris v.4.67, as cited in
Test species/strain:Salmonella typhimurium TA100, TA1535, TA98, TA1537, Escherichia coli WP2 uvrA
Schmidt WM (1984). Isophorondiisocyanat (IPDI) - Untersuchungen zur sensibilisierenden Wirkung an der Meerschweinchenhaut (modif. "Maximierungstest" mit nur intrakutaner Induktion). Bayer AG (Wuppertal) Report No. 13041 (unpublished).
Method: other: Modified maximization test: - Second induction intracutaneous - Challenge treatment only 6 instead of 24 hours
SafePharm Laboratories Limited (1992) Dynasylan IBTEO: Oral|gavage one generation reproduction study in the rat. Project|number 395/4. Degussa-Huls AG-Nr.: 92-0267-DGR December 11,|1992
BASF AG, Technische Entwicklung Verfahrenstechnik,|Löslichkeitsmessung, unpublished study, J.No. 38-848, 18|Dec. 1979
Dow Corning Corporation (2006) Hydrolysis of|Hexamethyldisilazane (HMDZ). DCC HES Study Number 10119-102.
Infracor GmbH (2002b). Isophorone diamine, determination of|the immobilisation of Daphnia magna STRAUS (acute|immobilisation test). Report No. DK 781 (unpublished).
Method: other: Directive 92/69/EEC, C.2; OECD Test Guideline 202 (I) (1984)
Saccharomyces strain (no further information)
Shamberger R (1971). Inhibitory effect of vitamin A on|carcinogenesis, J. Natl. Cancer Inst., Vol. 47, pp. 667-673.
Method: other: initiation/promotion study
Short-term toxicity to fish, IUC4#34/Ch.4.1
Wang X, Yin C, Wang L-S (2002) Structure-Activity|Relationships and Response-Surface Analysis of|Nitroaromatics Toxicity to the yeast. Chemosphere 46: 1045 -|1051
Method: other (calculated): using SRC-WSKOW software
Bringmann G and Kuehn R (1982). Ergebnisse der Schadwirkung|wassergefaehrdender Stoffe gegen Daphnia magna in einem|weiterentwickelten standardisierten Testverfahren. Z. Wasser|Abwasser Forsch. 15 (1), 1-6.
Method: other: Bringmann and Kuehn (1982)
Bayer AG (1989) Unpublished Internal Test Results
Monsanto Chemical Co. (1986) unpublished study Project SRI|LSC-2112-3 9/86. Cited in letter from BGVV 06.05.1996
Barrow et al. (1977), Arch Environ Health, 32, 68-76.
Bayer AG (1978). Institute of Toxicology. Acute oral|toxicity. Unpublished short report dated April 21, 1978.
Khadzhieva, E.D., Gig. Trud. Prof. Zabol. 10, 22-24 (1969),|zitiert nach: Izmerov, N.F., (ed.), IRPTC, Vol. 35:|Caprolactam, Centre of International Projects, GKNT, Moscow|(1983)
Method: other: according to Williams, Cancer Res. 37,1845 (1977); Cancer Lett. 4, 69 (1978); see also freetext Method
Hill Top Research, Inc. 1971. Report: VA-73. Acute toxicity and irritation studies on sample TM-181. 16.3.1971.
2-ethylhexyl 4-butyl-10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-7-oxo-8-oxa-3, 5-dithia-4-stannatetradecanoate (IUC4 DSN 32)
BASF AG, Department of ecology; unpublished report|01/296/88, (17.08.1988)
BASF AG, Analytical Department; unpublished data (Fixapret|CPN 45%); (J.Nr. 12501; 22.07.74)
NTP (Department of Health and Human Services, National|Toxicology Program) (1984). NTP Studies on|N-Ethylmorpholine, Study ID. 432404.
Vogel E.W. and M.j.m. Nivard: Mutagenesisi 8, 57-81, (1993)
diisooctyl 2,2'-[(dibutylstannylene)bis(thio)]diacetate (IUC4 DSN 27)
Fujita, H. and Sasaki, M. (1987) Mutagenicity test of food|additives with Salmonella typhimurium TA97 and TA102 (II).|Ann. Rep. Tokyo Metr. Res. Lab. P.H., 38, 423-430. (in|Japanese)
DuPont Chem (1981) Inhalation Median Lethal Concentration.|December 22, 1981: NTIS/OTS 0570956
Jaekel K (1991) FAT 65'023/N: Report on dissociation|constant in water. CIBA-GEIGY Ltd., CH-4002 Basel|(Switzerland)
Method: other: Dissociation in water estimated
Ministry of Environment (MOE), Korea(2001), The Acute toxicity of Acetanilide to Aquatic Invertebrate; daphnia (tested by KRICT)
Method: other: : Acute toxicity test to Daphnia, Testing of industrial chemicals, Ministry of Environment, Korea
Tokiwa H, Nakagawa R, Ohnishi Y (1981) Mutagenic assay of|aromatic nitro compounds with Salmonella typhimurium. Mut|Res 91: 321-325
Method: other: according to Ames, Mutat. Res. 31, 347 (1975)
Parry EM (1985) Tests of effects on mitosis and mitotic|spindle in Chinese hamster primary liver cells in culture.|Prog Mut Res 5: 479-485
Method: other: differential staining technique described by Wissinger et al. (1981)
Microbiological Associates (1984c). Unscheduled DNA|synthesis in rat primary hepatocytes. Report T2408.380003.
Method: other: based on Williams, G.M. (1976), Cancer Lett. 1, 231-236
Salmonella typhimurium strains TA1535, TA1537, TA98, and TA100, and Escherichia coli strain WP2uvrA-
Ono Y, Somiya I and Kawamura M (1991). The Evaluation of|Genotoxicity using DNA repairing test for chemicals produced|in chlorination and ozonation processes. Wat. Sci. Tech. 23,|329-338
Method: other: method originally developed by Oda Y and Nakamura S et al. (1985). Mut. Res. 147, 219-229
ICI: (1949) Unpublished information (cited in PMA, 1971)
CIIT (1982) A Ninety-Day Study of Terephthalic Acid (CAS No.|100-21-0) Induced Urolithiasis and Reproduction Performance|in Wistar and CD Rats. CITI Docket 11622
Method: other (measured): spectrochemical detection
van der Walle H. et al.: Cont. Dermat. 8, 147-154, (1982)
human cell lines:TK6-cells ((thymine kinase locus) and AHH-1-cells (Hypoxanthine guanine phosphoribosyl transferase locus)
Adema DMM (1982). Tests and desk studies carried out by MT-TNO during 1980-1981 for annex II of marpol 1973. Rep.No. CL82/14, 52 pp. TNO, Delft (NL).
Method: other: see Reference / Test Conditions
Frei, E. et al: J. Cancer Res. Clin. Oncol. 111, 123-128|(1986), No information
Genetic toxicity in vitro, IUC4#202/Ch.5.5
Method: other (measurement): shake flask method
Mortelmans, K. et al.: Environ. Mutagen. 8, Suppl. 7, 1-119|(1986)
BIBRA Toxicity profile (1987). Glycerol. (Grant, 1974).
Ciba (1989h). Test for Inhibitory Concentration of TK 10027|on Aerobic Bacteria. Unpublished report # 894082. April 12,|1989.
Battelle Europe. 1993. A Study of the Toxicity to Algae|(Scenedesmus subspicatus) of Isophthalic Acid. Final|Report. Study Number: BE-EA-128-91-02-ALG-2.
Sanchez-Bayo, F. 2006. Comparative acute toxicity or organic pollutants and reference values for crustaceans. I. Branchiopoda, Copepoda and Ostracoda. Environmental Pollution. 139:385-420.
Batiste-Alenstorn M, Xamera N, Creus, Marcos R (1991)|Genotoxicity studies with the unstable Zeste-White (UZ)|system of drosophila melanogaster. Environ Mol Mutagenesis|18, 120-125
Method: other: Rasmuson et al. (1984): Eye pigmentation changes in Drosophila melanogaster in "Handbook of Mutagenicity" (Kilbey et al eds), 603-613
Bengtsson, B.E. (1978). Use of a harpacticoid copepod in|toxicity tests. Mar. Poll. Bull. 9:238-241.
Salmonella typhimrium TA98, TA100, TA1535 and TA1537
Thorgeirsson A (1978). Sensitization capacity of epoxy resin|hardeners in the guinea pig. Acta Dermatovener (Stockholm)|58, 332-336.
Method: other: Magnusson B, Kligman AM (1969). J. Invest. Dermatol. 52, 268.
BASF AG, Product Safety, 6-Methylhept-5-en-2-one|(Methylheptenon) Subchronic toxicity study in Wistar rats,|administration by gavage for 3 months, unpublished report,|project no. 51S0874/00114, 00/874, 05 Dec. 2002
Kier LE, Brusick DJ, Auletta AE, Von Halle ES, Brown MM,|Simmon VF, Dunkel V, McCann J, Mortelmans K, Prival M, Rao|TK, Ray V (1986) The Salmonella typhimurium/mammalian|microsomal assay. A report of the U.S. Environmental|Protection Agency Gene-Tox Program. Mutat Res 168: 69 - 240
Bayer Industry Services (2004e). Algae Toxicity, Growth Inhibition Test of 1,4-Dichloro-2-butene. Unpublished Report No. 1326 A/04 Al.
Method: other: Directive 92/69/EEC, C.3 in most parts equivalent to the OECD TG 201
Method: other: Japanese Guideline by MITI of 1974; corresp. OECD 305 C Bioaccumulation (1981)
Heidemann A. Chromosome aberration assay in Chinese hamster|V79 cells in-vitro with FAT 65'023/L. Report CCR Project No.|231322, January 21, 1991. CCR Cytotest Cell Research,|Rossdorf, Germany.
Method: other: Simulation of a laboratory sewage treatment plant with TOC
Jelinek, R. et al., Indian J. Exp. Biol. 23, 588-595 (1985)
Method: other: Chick Embryotoxicity Screening Test (CHEST)
de Roode, D.F. and H.P.M. de Haan. 2004. Tetraoctylstannane [Tetraoctyltin, CAS No. 3590-84-9]: Daphnia magna, reproduction test (semi-static). NOTOX Project 375108. December 15, 2004.
Dowden, B.F. (1961): Cumulative toxicities of some inorganic|salts to Daphnia magna as determined by median tolerance|limits. Proc. La. Acad. Sci. 23, 77-85
BASF (1982) Zahn-Wellens test (mucochloric acid). BASF AG,|Dpt. of Ecology, 03.02.1982 (unpublished data; Reprint|05.07.2002)
Schering AG, Experimentelle Toxikologie. 1998. Acute immobilization test of di-n-butyltin oxide (ZK 26385) with Daphnia magna. Research Report No. IC26. Berlin, Germany. 03 December 1998.
Method: other: OECD Guideline 202(1); Directive 92/69/EEC (2); OECD ENV/JM/MONO 2000(6) - Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures (26 June 2000)
Errécalde, O., M. Astruc, G. Maury, and R. Pinel. 1995. Biotransformation of butyltin compounds using pure strains of microorganisms. Applied Organometallic Chemistry. 9:23-28.
Meng Z, Sang N, Zhang B (2002) Effects of derivatives of|sulfure dioxide on micronuclei formation in mouse bone|marrow cells in vivo. Bull Environ Contam Toxicol 69:|257-264
Method: other: test procedure comparable to OECD guideline 474
Lyman W.J.; Reehl W.F.; Rosenblatt D.H.: Handbook of|Chemical Property Estimation Methods. American Chemical|Society, Washington, DC (1990).
American Public Health Association. 1971. Standard Methods for the Examination of Water and Wastewater. 1971. 13th Edi, New York, NY.
BASF AG, Laboratory of Ecology and Environmental Analytics,|unpublished data (1978)
Method: other: in vivo DNA damage - mammals (somatic cells/DNA-protein crosslinks, Alkaline filter elution assay)
Genetic toxicity in vivo, IUC4#85/Ch.5.6
BASF AG, 2004, Department of Product Safety, unpublished|calculation, SRC AOP v1.90, 29 June 2004
Method: other (calculated): via SRC AOP v1.90
Monsanto (1993) Degradation of|N-(1,3-Dimethylbutyl)-N´-phenyl-1,4-phenylenediamine.|Unpublished report MO-93-9110 (ES-93-SS-05)
Takemoto K, Yoshimura H, Matsushita S (1978) Experiment of|pulmonary tumorgenicity of benzotrichloride. Proc of 51st|Annual Meeting of Japan Assoc of Ind Health 514 - 515. TSCA|8e Submission 8EHQ-0980-0360 Document No. 86-8000116,|Washington, DC: Office of Toxic Substances, U.S.|Environmental Protection Agency
Saccharomyces cerevisiae D6, D61-M, D7, PV-2, PV-3
Toth et al. (1990). Effects of chlorine dioxide on the|developing rat brain. J.Toxicol.Environ.Health, 31 p29-44.
Torkelson TR, Wolf MA, Oyen R, Rowe VK (1959) Vapor Toxicity|of Allyl Alcohol as Determined on Laboratory Animals.|American Industrial Hygiene Association Journal|20, 224-229
Hüls AG (1991). In vitro mammalian cell gene mutation assay|with Laurolactam. Report No. HP-91/0016 (unpublished)
Clariant GmbH, (1985) Unpublished testing report titled|"o-Chlorbenzylchlorid D, Augenreizung am Kaninchen", Report|No.: 85.0678, 15.07.1985, conducted by HOECHST AG, Pharma|Forschung Toxikologie.
Institut Fresenius (1997) Determination of the Octanol-Water|Coefficient for IOTG. Project number IF 97/02344-00
Probst GS, Hill LE (1985) Tests for the induction of|DNA-repair synthesis in primary cultures of adult rat|hepatocytes. Prog Mut Res 5: 381-386
Method: other: autoradiographic assay for UDS
Genetic toxicity in vitro, IUC4#109/Ch.5.5
Mellerio, J. and Weale, R.A. (1966). Hazy vision in amine|plant operatives. Br. J. Ind. Med. 23(2), 153-154.
Method: other: in general conformance with OECD 471 (with modification)
Nishioka K, Murata M, Takehito I, Kaniwa M (1996) Contact|dermatitis due to rubber boots worn by Japanese farmers with|special attention to|6-ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline (DMTDQ)|sensitivity. Contact Dermatitis 35: 241-245
Heidelberger CH, Freeman AE, Pienta RJ, Sivak A, Bertram JS,|Casto BC, Dunkel VC, Francis MW, Kakunaga T, Little JB,|Schechtman LM (1983) Cell transformation by chemical agents.|Mutat Res 114: 283-385
Method: other: according Rhim et al., 1973
Tadokoro, H. et al. (1992) (CITI; Japan). Draft Report to III,|Project FE-E-66-1,2,3.
Abdel-Rahman MS, Couri D and Bull RJ (1984). Toxicity of Chlorine Dioxide in Drinking Water. Journal of the American College of Toxiclogy, 3(4), 277-284.
Schultz et al. (1978) Arch. Environ. Contam. Toxicol. 7,|457-463
Method: other: males(24 hrs old), mated with 3x with Basc virgin females brood1: 3d, brood2: 2d, brood3: 2d;
Genetic toxicity in vitro, IUC4#166/Ch.5.5
Battelle Europe. 1991. Study on the "Toxicity of|Isophthalic Acid towards Bacteria According to OECD-Test|Guideline 209 (Activated Sludge, Respiration Inhibition|Test. Study No: BE-EA-128-91-01-BHT-02.
Ross S.D.: The rate of oxidation of thiodiglycol and|triethylamine by hydrogen peroxide. J. Am. Chem. Soc. 68,|1484-1485 (1946)
Escherichia coli WP2uvrA, Salmonella typhimurium TA 98, TA 1535, TA 1538
Portmann JE and Wilson KW (1971). The toxicity of 140|substances to the brown shrimp and other marine animals.|Shellfish Information Bulletin 22, Ministry of Agriculture,|Fisheries & Food, Fisheries Experimental Station, Conway, N.|Wales, UK.
Cohen H J, Johnson JL, Rajagopalan KV (1974). Molecular|basis of the biological function of molybdenum.|Developmental patterns of sulfite oxidase and xanthine|oxidase in the rat. Arch. Biochem. Biophys. 164, 440-446.
Liu, J. and Lang, P., Toxicities of nitroaromatic compounds|to Scenedesmus obliquus and toxic symptoms, Huanjing Kexue|16, 7-10 (1995)
Method: other: OECD 201(Algae, Growth inhibition test, 1981)
Flick, E.W. 1991. Industrial Solvents Handbook. 4th ed. Noyes Data Corp. Park Ridge, NJ. P.815.
Method: P09-03:sated to be measured, details not given
Merkord, J. and G. Henninghausen. 1984. Beeinflussung akuter toxischer Wirkungen von Di-n-butylzinndichlorid durch meso-2,3-Dimercaptobernsteinsaure. Pharmazie. 39:572-573.
Streptomyces coelicolor A3, Aspergillus nidulans (Haploid strain 35)
BASF AG, department of ecology, unpublished data (0288/88),|30.03.1988 (9/0288/88)
The Merk Index. 10th ed. Rathway, New Jersey: Merck Co.,|Inc., 1983, p. 945
Dill DC and Milazzo DP (1988) "DOWANOL* PM glycol ether: Evaluation of the toxicity to the green alga, Selenestrum capricornutum printz", unpublished report of the Dow Chemical Company.
BASF AG, 2002, Product Safety, SRC AOP v1.90, data|assessment, 16 July 2002
Method: other (calculated): using AOP v1.90
Grbic-Galic, D. & Young, L.Y., Appl. Environ. Microbiol.|50, 292-297 (1985)
Method: other: anaerobic degradation, static
Gizhlaryan MS (1981). Toxicity of chlorine-substituted butenes in relation to the position of chlorine in a molecule. Gig. Sanit. 46 (1), 92-93.
Method: other: comparable to OECD guide-line 415
Clayton GD and Clayton FE (1994). Patty's Industrial Hygiene|and Toxicology. Toxicology 2A, 2B, 2C, 2D, 2E, 2F, 4th ed.|John Wiley & Sons Inc., New York, NY, 1055.
Salmonella typhimurium; TA98 TA100 TA1535 TA1537
Standard plate test and pre-incubation test
Bridie A., Wolff C. & Winter M., The acute toxicity of some|petrochemicals to goldfish, Water Res. 13: 623-626, 1979|(90)
Method: other: Standard Methods for Examination of Water and Wastewater. Am. Publ. Health Assoc. Inc., New York, Method No. 231
Weidenhamer J., Macias F., Fischer N., et al., 1993, Just how insoluble are monoterpenes?, J. Chem. Ecology 19 (8):1799-1807
Baer F and Griepentrog F (1967). Die Situation in der|gesundheitlichen Beurteilung der Aromatisierungsmittel fuer|Lebensmittel, Medizin und Ernaehrung 8, 244-251
BASF (1988): Natrium-disulfit, Wachstumshemmtest in|Anlehnung an Bringmann-Kühn. DUU/OO - A 520. File No.|9/0897/88, 29.07.1988
BUA (2005). Triphenylphosphine oxide. Calculation of bioconcentration factor with BCFWIN v2.15, 2000
Method: other: calculated SRC - BCFWIN v2.15
de Roode, D.F. 2004. Amendment I to NOTOX Project 375064/TNO Study V5310/01 (final). December 2004.
Method: other: OECD Guide-line 471, Guidelines for Screening Toxicity Testings of Chemicals (Japan)
Covance Laboratories (1998). Formi LHS. Mutation at the|thymidine kinase (tk) locus of mouse lymphoma L5178Y cells|(MLA) using the Microtitre Fluctuation technique.|Unpublished study report No. 1516/11-D5140 dated January|1998. Sponsored by Hydro Nutrition, Oslo.
Ullmann L. Acute dermal toxicity study with FAT 65'023/L in|rats. Report RCC Project 288483, December 21, 1990; RCC|Research & Consulting Company AG, Ittingen, Switzerland.
Acute toxicity: dermal, IUC4#11/Ch.5.1.3
Method: other: Activated sludge simulation test; fill-and-draw-type unit
MHW, Japan (1997) Ministry of Health and Welfare, Toxicity Testing Reports of Environmental Chemicals, Vol 5 (159-160)
BASF AG, Department of ecology and environmental analytics,|unpublished data on determination of the biodegradability of|Glyezin A in the DOC Die-Away Test, Project No.:|99/0200/21/1, Nov. 1999
Method: other: OECD Guide-line 301 A (new version); 1993
Shin, C.-G. et al.: Teratogen. Carcinogen. Mutagen. 10,|41-52 (1990);|cited in: RIFM database, location no. 11882
Hoechst AG (1996): Interne Berechnung, Abt. SU Umwelt/|Produktsicherheit (19.04.1996)
Amoco Corporation (1990) Abbreviated Acute Dermal Irritancy|/ Corrosivity Study of Terephthalic Acid in Rabbits.|Conducted by IIT Research Institute. IITRI Study #1556
Chou W.L., Speece R.E., Siddiqie R.H. and McKeon K. The|Effect of Petrochemical Structure on Methane Fermentation|Toxicity. Prog. Water Technol. 10(5/6):545-558. 1978.
APCI, 1,4-Diazabicyclo[2.2.2]Octane (Static): 96-Hour Acute|Toxicity Study in Carp (OECD 203), unpublished study, APCI|RRRS EXT-00/006, 28 Feb 2000
Sailstad, D.M. et al.: Toxicol. Methods 3, 169-182 (1993), No information
BASF AG, Department of Ecology, unpublished study,|9/0012/88, 18.02.1988
Method: other: German National Standard: DIN 38412, Part 8, Determination of the inhibitory effect on the cell multiplication
RÖMPP (2006). Online database, Georg Thieme Publishers,|Germany, request dated 05 Oct 2006.
Mori M, Totsuka Y, Fukutome K, Yoshida T, Sugimura T,|Wakabayashi K (1996) Formation of DNA adducts by the|co-mutagen norharman with aromatic amines. Carcinog 17:|1499-1503
Method: other: 32 P-post labelling method
Hazleton France (1988): Rapport No. 801300 to Rhone-Poulenc|S.A.
Method: other: guideline not specified, but protocol close to the current guidelines
Loden, M. et al.: National Environment Protection Board|170-488-85, FAO Report E40023 (1985)
Analytical Bio-Chemistry Laboratories, Inc. 1990. Chronic Toxicity of Dibutyltin Dichloride to Daphnia magna. ABC Final Report #38311. Sponsored by the Consortium of Dibutyltin Manufacturers [M&T Chemicals, Inc., Woodbridge, NJ - Administrator]. 11.10.1990.
Method: other: USEPA - Hazard Evaluation Division Standard Evaluation Procedure. Daphnia magna Life-Cycle (21-Day Renewal) Chronic Toxicity Test [EPA 540/9-86-141]
S. typhimurium strains TA98, TA100, TA1535 and TA1537
Stirling, D.I., and Dalton, H.: FEMS Microbiol. Letters|5:315-318 (1979).
Mercier, O. (1992a). Hazleton France. Test to evaluate the|acute primary cutaneous irritation and corrositivity in the|rabbit. Report number: 201350, Study conducted for Wacker|Chemie GmbH.
Jacobs GA and Martens MA (1989) An Objective Method for the|Evaluation of Eye Irritation In Vivo, Food and Chemical|Toxicology 27, 255-258
Acute toxicity: inhalation, IUC4#54/Ch.5.1.2
Petrosyan FR, et al (1982) ZH EKSP KLIN MED 22 (3), 225.
Repeated dose toxicity: oral, IUC4#46/Ch.5.4
Sangster J., Octanol-Water Partition Coefficients of Simple|Organic Compounds, J. Phys. Chem. Ref. Data, Vol. 18, No.|3, 1989, No information
Yefremova, G.I. and Filippova, L. M.: Mutat. Res. 23,|347-352 (1974);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Method: other: 5 rats/sex/dose group, observed for mortality,clinical signs of toxicity; weighed initially, after 1 week and at necropsy, feed consumption measured weekly
Bodes E, Nakamura J, Swenberg JA (2003) SOT Annual Meeting.|Abstract No. 994.
Mertens, J.J.W.M., 1997. A 24-month chronic dietary study of|methyl bromide in rats. Unpublished report from WIL Research|Laboratories, Project No. WIL-49014.
Method: other: 83-5 (FIFRA Guideline, Subdivision F: Protocol 83-5)
Kier, L.E., Brusick, D.J., Auletta, A.E., Von Halle, E.S.,|Brown, M.M., Simmon, V.F., Dunkel, V., McCann, J.,|Mortelmans, K., Prival, M., Rao, T.K. and Ray, V. (1986),|"The Salmonella typhimurium/mammalian microsomal assay: A|report of the U.S. EPA Gene-Tox Program", Mutation Research|168, pp. 69-240
van Ginkel, C.G. (1990) Biodegradability of|N-aminoethylpiperazine. Unpublished report CRL F90122 of|Akzo NV.
BASF AG, 1999, Substance data service, Dampfdruck von|2-Methyl-2-hepten-6-on, unpublished study, report No.|99.271, 06 April 1999
Hirose, M. et al. (1981) Food Cosmet. Toxicol. 19, 147-151
Dow Chemical Co. data, EPA OTS 86860000127 (1956) cited in|BIBRA Toxicity Profile (1991)
Little LW and Lamb JC (1972). Acute toxicity of 46 selected|dyes to the Fathead minnow (Pimephales promelas), UNC|Wastewater Research Center, Department of Environmental|Sciences and Engineering, University of North Carolina, USA,|prepared for Ecology Committee, American Dye Manufacturers|Institute, Inc., September 1972.
Method: other: APHA Standard Methods (1971)
Method: other: modified to Maron and Ames (1983)
Waggy GT and Payne JR. 1974. Environmental impact product|analysis. Acute aquatic toxicity testing. Union Carbide|Corporation, Research and Development Department. Project No|910F44, dated January 25, 1974.
Schering AG. Studies on the Mutagenic Potential of ZK 26.384 in the Mouse Micronucleus Test. Report No. IC17/89. 11.04.1989.
Escherichia coli B/Sd-4/1,3,4,5 and B/Sd-4/3,4
Method: other: cytogenetic assay with bone marrow cells after inhalation exposure of test animals
Bradford, J.C. et al.: Environ. Mutagen. 5, 402 (1983);|abstract;|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Unpublished Report (1980) Evaluation of six ethylene amines|in the Salmonella/microsome mutagenicity test, unpublished report number R 6510, June 1, 1980, as conducted by TNO Nutrition|and Food Research.
Kennedy GL (2008) Tumor Incidences from the 2 year inhalation carcinogenicity study of Lee et al. 1987, DuPont, personal communication, March 2008
Method: other: comparable to OECD Guide-line 453
Method: other: US EPA (1971) Algal Assay Procedure: Bottle Test EPA 1972-795-146/1
Wagner, H. and K. Neumann: Z. Physik. Chem. (Frankfrut), 28|51 (1961)
Juhnke I. und Luedemann D.: Z. Wasser Abwasserforsch. 11,|161, (1978)
Ames, B.N. et al., Proc. Nat. Acad. Sci. USA 70, 782-786, 1973
Gluconate Handbook. PMP-01 Fermentation Products, Inc.|Chicago, Illinois. Certificate: No. 30823.
Schmeidel KW, Decker D (2000) Resorcinol. In: Ullmanns' Encyclopedia of Industrial Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA. 1-14.
CIBA-GEIGY, Ltd. 1982. Report TK 11339. Acute Oral LD50 in the Rat. GU Project No. 820546. 21.06.1982.
Honeywell (2005) OS® 2000: Material Safety Data Sheet. Issue|date October, 2005.
Mitsubishi Gas Chemical Co., Unpublished Report, 2002, Micronucleus Test of 3-Methylbenzoic Acid
Bayer AG (1986). Chronic toxicity of 2,4-DNT to Daphnia|magna. Unpublished Report (no Reg-No).
Method: other: OECD Guideline 202 (adopted: 04.04.84) "Daphnia sp., Acute Immobilisation Test and Reproduction Test"
BASF AG, Product Details N-METHYLPYRROLIDONE DIST., 24.10.2005
CERI. (2004) Measurement of hydrolysis of p-toluic acid. Unpublished data.
Brambilla G, Martelli A, Robbiano L (1991) Use of Human and|Rat Hepatocyte Primary Cultures for Dection of Interspecies|Differences in Genotoxicity. Eurotox Congress 39
Method: other: alkaline-elution technique, exposure time: 20 hours
Genetic toxicity in vitro, IUC4#105/Ch.5.5
S. typhimurium TA100, TA1535, WP2uvrA, TA98, TA1537
Method: other: according to Green, M.H.L.: in: Kilbey, B.J. et al. (eds): Handbook of Mutagenicity Test Procedures, 2nd ed. Amsterdam, Elsevier, 161-187, (1984)
Encyclopedia Chimica, Kyoritu Shuppan, Japan (1963)
Kidney cells of the Syrian hamster (BHK 21/cl 13) Human fibroblasts (WI-38) Human liver cells (Chang)
Chinese hamster ovary cells (CHO-W-B1 cells)
Method: other: 10 rats/dose/sex, mating in the 13th. week of treatment, hematol.,biochem.,histol. examination; analysis of the function of reproduction
Working, P.K. and Bus, J.S.: CIIT Activities, 6(8): 1, 3-6|(1986).
Tomlinson, T.G., Boon, A.G., Trotmann, C.N.A. (1966) Inhibition of nitrification in the activated sludge process of sewage disposal. J. Appl. Bact. 29(2), 266-291
Salmonella typhimunium TA98, TA100, TA1535, TA1537, TA1538.
Leo, A.J. (1982) LogP Values Calculated Using the CLOGP Program for |Compounds in ISHOW Files. Pomona College Medicinal Chemistry Project, Seaver Chemistry Laboratory, Claremont, CA, 1982 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com)
Kornbrust, D.J., Bus, J.S., Doerier, G., and Swenberg, J.|A.: Toxicol. Appl. Pharmacol. 65(1): 122-134 (1982a).
Prehled Prumyslove Toxikol Org Latky 317 1986 Cited in RTECS
Degussa AG, Natriumpersulfat; Prüfung auf sensibilisierende|Eigenschaften an der Haut des Meerschweinchens|(Optimierungs-Test), Study no. 85-0048-DKT, 1985.
Gigiena Truda i Professional'nye Zabolevaniya, 18(7), 57, 1974
Hexabromocyclododecane (HBCDD)_25637-99-4
ATOFINA, Levallois Application Center, 2001.|UNDECANOIC ACID, 11-AMINO.Algal growth inhibition test.|Study number : 493/00/B.
Method: other: calculated with SRC-BCFWIN v2.15, 2000
Delaware State Medical J., 31, p. 276, 1959.
Furukawa, F. et al., (1980): Oral Acute and Subchronic|Toxicity Studies for Sodium hypochlorite in F-344 Rat, EISEI|KENKYUSHO HOUKOKU Japan, 98, 62-69
Juhnke I. and Lüedemann D. (1978) Results of the testing of|200 chemical compounds for acute toxicity in fish by the|orfe test. Z. Wasser- Abwasser-Forsch., 11(5):161-164.
CIT (1999) Skin Sensitization Test in Guinea Pigs|(Maximization method of Magnusson, B. and Kligman, A.M.).|Centre International de Toxicolgie. Study #: 16571 TSG. |Study Date: January 14, 1999.
ETAD (1998). Breslin WJ. A pilot prenatal developmental|toxicity study via oral gavage to New Zealand White rabbits.|MPI Research Laboratory Study Identification 795-002, August|18, 1998.
Tkalec, M., Vidakovic-Cifrek, V. and Regula, I. (1998) The|effect of oil industry high density brines on duckweed Lemna|minor L. Chemosphere, 37(13), 2703-2715.
Lonza AG, unpublished report, 1993, Metaphase chromosome analysis of human lymphocytes, Huntingdon Research, Lonza Report No. 2015
Method: other (measurement): Column capacity determination
Method: other: Salmonella/Mammalian-Microsome Plate Incorporation Mutagenicity Assay with a Confirmatory Assay
[2-(2-methoxymethylethoxy)methylethoxy]propanol (IUC4 DSN 55)
Gorecka-Turska, D. et al. (1983) Bromat. Chem. Toksykol.,|XVI 1, 37-42.
Salmonella typhimurium TA 100, TA 1535, TA 1537, TA 1538
Gopalan HNB, Njagi GDE (1978) Cytogenetic effects of food|preservatives sodium sulphite and sodium benzoate. Genetics|88: 32-33
Francalani, S. et al. (2000), Multicentre study of allergic|contact cheilitis from toothpastes, Contact Dermatitis 43,|216-222
Fibroblasts of the Chinese hamster (CHL)
Brooks, T.M. et al. (Sittingbourne Research Centre, Shell|Research Ltd.) (1976):|In: Shell Oil Co. (1992): NTIS/OTS 0539579
Bayer AG (1984). Pauluhn J, Machemer L. Phosphortrichlorid,|-oxichlorid/ Dekontamination nach Hautkontakt. Bayer AG|data, 1984-07-26. Study No: T 401 7808.
Marciniec, B. (1975) Oxidative Splitting of the Si-H Bond.|Part II. Manometric Study of the Reaction of|Trimethoxysilane with Copper (II) Salts in Methanol. Rocz.|Chem., 49, (1975) 1565.
Sax NI (1979). Dangerous Properties of Industrial Materials.|5th ed. VNR Company, 914.
Melting point/freezing point, IUC4#35/Ch.2.1
Schering AG. 1988. Determination of the Water Solubility of Tetra-n-Butyltin. Report No. VE 03/88. 24.10.1988.
Florin I, Rutberg L, Curvall M, Enzell CR (1980) Screening of tobacco smoke constituents for mutagenicity using the Ames' test. Toxicology 18:219-232.
Toxicity to microorganisms, IUC4#52/Ch.4.4
Waegemaekers T. und Bensink M.: Mutat. Res. 137, 95-102,|(1984)
Developmental toxicity / teratogenicity, IUC4#31/Ch.5.8.2
Dooley, C.A. and P. Kenis. 1987. Response of Bioluminescent Bacteria to Alkyltin Compounds. In: Proc. Intern. Organotin Symp. Oceans 87 Conf. Halifax, N.S., Canada. Sept. 28-Oct. 1. 4:1517-1524.
ABC Lab Inc. (1990). Acute flow-through toxicity of sodium|formate (C-1261) to Daphnia magna. Analytical Biochemistry|Laboratories Inc., report No. 38314 for Hoechst Celanese|Corp., 13 March 1990, unpublished.
Bioaccumulation: aquatic / sediment, IUC4#7/Ch.3.7
Hirose M, Inoeu T, Asamoto M, Tagawa Y (1986) Comparison of the effects of 13 phenolic compounds in induction of proliferative lesions of the forestomach and increase in the labelling indices of the glandular stomach and urinary bladder epithelium of Syrian golden hamsters. Carcinogenesis 7(8):1285-1289.
Dowden, B.F. & Bennett, H.J. (1965): Toxicity of selected|chemicals to certain animals. J. Water Pollut. Control Fed.|37(9), 1308-1316
Huls (1995) Determination of the acute toxicity of|Isobutyltriethoxysilan (DYNASYLAN IBTEO) to the earthworm|(Eisenia foetida) (Acute Toxicity to the Earthworm Test;|Guideline 88/302/EEC). Final Report RW 004. Degussa|AG-US-IT-Nr.: 92-0233-DGO April 9, 1992
Skackova, I.N. 1967. Hygienic substantiation of the maximum permissible concentration of tetraethyltin in water bodies. Gigiena i Sanitariya. 4:11-17. (in Russian)
Hermanutz, R.O. et al. (1990), Water Chlorination 6,|463-477.
DuPont (1986). Long term inhalation study with 1,4-dichlorobutene-2 (DCB) in rats. Haskell Laboratory, Report No. 43-86 from January 30, 1986 (NTIS OTS 509754).
RCC NOTOX, Acute eye irritation/corrosion study with|natrium benzoate in rabbits (study no. 014669). RCC NOTOX|B.V., 's-Hertogenbosch
Method: other (calculated): according Leo, Hansch et al.: Chem. Rev. 71, 525
Hardy CJ, Coombs DW, Lewis DJ, Klimisch HJ. 1997. Twenty-eight-day repeated-dose inhalation exposure of rats to diethylene glycol monoethyl ether. Fund Appl Toxicol 38:143-147.
Escherichia coli WP2 try hcr, WP2 B/r try; Salmonella thyphimurium TA98, TA 100, TA 1535
Daubert, T.E. and R.P. Danner. Data Compilation Tables of|Properties of Pure Compounds. 1985. Design Institute for|Physical Property Data, American Institute of Chemical|Engineers.
Repeated dose toxicity: oral, IUC4#160/Ch.5.4
Bringmann G (1978). Bestimmung der biologischen Schadwirkung|wassergefaehrdender Stoffe gegen Protozoen.I.|Bakterienfressende Flagellaten (Modellorganismus: Entosiphon|sulcatum Stein). Z. Wasser- Abwasser-Forsch. 11 (6),|210-215.
Brusick, D. (1988). Genotoxic effects in cultured mammalian|cells produced by low pH treatment conditions and increased|ion concentrations. Env. Mutagenesis 8:879-886.
Hüls AG (1988a). Isophorondiamin (IPD): Micronucleus-Test|(unpublished).
Method: other: Directive 79/831/EEC, B.12
KOWWIN Version 1.66.|(http://www.epa.gov/oppt/exposure/docs/episuitedl.htm
Method: other: Early life stage test according to Adema, report RIV 627905 001, National Institute of Public Health and Environmental Protection, Bilthoven, Netherlands
Kihlman, B.A. et al.: Herditas 69, 35-50 (1971)|cited in: Grant, W.F.: Mutation Res. 99, 273-291 (1982)
Yi J., Zhang J. and Gao Y., Experiment on the effect of|formaldehxde on the sperm toxicity of mice, Gongye Weisheng|Yu Zhiyebing (Ind. Health and Occup. Dis.) 26(5), 263 - 264,|(2000), No information
Method: other: glass-walled chamber of 160 l
Spanjers MTh and Til HP (1981). Determination of the acute|oral toxicity of Kali Waterglass 35.5/36.5 (2.25) in rats,|Instituten CIVO, Toxicology and Nutrition, TNO, Report|R0100873, Zeist, The Netherlands.
Method: other (calculated): SRC MPBPWIN v1.41
Gibson, J.E. 1982. A ninety day study of terephthalic|acid-induced urolithiasis and reproductive performance in|Wistar and CD rats. Research Triangle Institute|Experimental Pathology Laboratories, Inc. Chemical Industry|Institute of Toxicology.
Noack U (1995b). Laboratorium für angewandte Biologie. Acute|Immobilisation test (48) of tungsten carbide (WC) HCST|product designation WC DS 100 to Daphnia magna Strauss,|Study No. DAI42411.
Ullmann L (1980b). Report on eye irritation in the rabbit|after single application of FAT 65'023/K. Final report,|March 6, 1980. Exp. Toxicology, Ciba-Geigy Ltd., Sisseln,|Switzerland.
Method: other: calculation with BCFWIN v2.14
Hüls AG (1996b). Bestimmung der Bakterientoxizität von|Isphorondiamin nach Bringmann und Kühn. Report ABBK-IPDA|(unpublished).
Method: other: Bringmann and Kühn (1977), Z. Wasser Abwasser Forsch. 10, 87-98
Amoco Corporation (1993) A Study of the Acute Toxicity to|Fish (Leuciscus idus melanotus) of Terephthalic Acid.|Conducted by Battelle Europe; Study # BE-EA-128-91-01-F3A-3;|Reference no. 21
Toxicity to soil macroorganisms except arthropods, IUC4#13/Ch.4.6.3
Union Carbide Corporation. 1992a. Material Safety Data|Sheet. Dated March 20, 1992. C0269D. Solvents and Coatings|Materials Division, Union Carbide Corporation. As cited in|Chemical Manufacturers Association. Summary of Responses to|the OECD Request for Available Data on HVP Chemicals.|February 8, 1999.
Method: other: 2-Stage Transformation Test (Focus Assay)
Genetic toxicity in vitro, IUC4#279/Ch.5.5
Yamaguchi S, Hirose M, Fukushima S, Hasegawa R, Ito N (1989) Modification by Catechol and Resorcinol of Upper Digestive Tract Carcinogenesis in Rats Treated with Methyl-N-amylnitrosamine. |Cancer Research 49(21):6015-6018 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved. www.nisc.com).
Test on stability in fish OECD medium. This study was conducted according to the OECD TG 203.
Method: other: according Yoshikura et al., 1979
BASF AG, Laboratory of Ecology, unpublished data, 19.09.1979, No information
Mortelmans, K. et al.: Environ. Mutagen. 8 (Suppl. 7), 1-119|(1986)
HRC (Huntingdon Research Centre, Deutschland) (1979b).|Verträglichkeitsprüfung am Auge nach einmaliger Applikation|beim Kaninchen. Report No. 326b.
CIBA-GEIGY, Ltd. 1980. Report on Acute Aerosol Inhalation Toxicity in the Rat of TK 10777. Project No.: 801469. 24.10.1980.
Acute toxicity: inhalation, IUC4#101/Ch.5.1.2
BASF AG (1987b). Analytical Laboratory, Bestimmung der|Akuten Bakterientoxizität; unpublished study, (314022,|10/87) [in German].
McGregor DB, Brown A, Cattanach P, Edwards I et al. (1988)|Response of the L5178Y tk+/tk- mouse lymphoma cell foward|mutation assay: III 72 Coded chemicals. Environ Molec|Mutagen, 12, 85-154.
Method: other: equivalent to OECD Guide-line 476
Salmonella typhimurium TA 1535, TA1537, TA 1538, TA 98, TA 100 and E.coli WP uvrA
Method: other: method described by Canton et al. (1975)
Appearance/physical state/colour, IUC4#15/Ch.1.1.1
Environment Agency of Japan (1999a). Ecotoxicity Testing|Report. Test 92068.
BASF AG, Bestimmung des Verteilungskoeffizienten log Pow |von n-Butylacrylat in 1-Octanol/Wasser bei Raumtemperatur,|unveroeffentlichte Untersuchung, Analytisches Laboratorium
LISEC (1999). Acute Toxicity of 5-Ethylidene-2-Norbornene|for fish, Brachydanio rerio. Report No. WE-03-192. LISEC,|Craenevenne, Genk, Belgium.
Method: other: OECD (1992) Guideline 203; Annex to Dir. 92/69/EEC (1992): Part C.1: Acute Toxicity for Fish; USEPA (1996) 712-C-96-118: OPPTS 850.1075
type of cell used: Chinese hamster CHL/IU cells
BASF AG (1990). Department of Ecology, project No.|9/1890733, 21 May 1990, unpublish
Method: other: following German Industrial Standard DIN 38412, Part 8
Greene, E.J and Friedman, M.A. (1979) unpublished report of Allied Chemical, Report #MA-12-77-13, May 1979 NTIS/OTS 206445, Doc ID 878213706 (1983) and NTIS/OTS 206440, Doc I.D." 878213791 (1983)
Method: other: 5 mice/sex/group, whole body exposure, complete necropsy on all mice, histopathological evaluation on all mice
Carrara G, Zoppellari I (1896). Velocità di reazione in|sistemi non omogenei. II. Scomposizione coll'acqua di alcune|combinazioni dello solfo e del fosforo. Gazz. Chim. Ital. 26|(1), 483-498.
Uno, Y. et al., Mutation Research 320, 189-205 (1994)
Genetic toxicity in vivo, IUC4#159/Ch.5.6
Method: other: similar to OECD 473; according to Galloway S.M. et al. Environm. Mutagen.7, 1-52 (1985)
Kaplun Z S and Mezencewa N W (1960). Experimentalstudie|ueber die toxische Wirkung von Staub bei der Erzeugung von|Sintermetallen. J Hyg Epidemiol Microbiol Immunol 4,|390-399.
Hirose, M. et al. (1993): Carcinogenesis 14, 2359 - 2364
BASF AG, General Info BETA-IONONE R, status 18 March 2004
Method: other: screening test, no further information available
ALOGS Program, (http://www.lhn.unil.ch/Appl/cchem2.html)
Method: other: calculated: ALOGS Program (assumes no hydrolysis)
BASF AG, Safety data sheet SICOTAN GELB L 1910, 04.07.2002|(30047688)
Guzzie, P.J., Slesinski, R.S., and Frank, F.R. (1987) |N-aminoethylpiperazine (AEP) in vivo mouse micronucleus|study. Unpublished report of Union Carbide
Method: other: followed EPA report 560/6-83-001
BASF AG (1988c). Department of Ecology, Bestimmung der|akuten Wirkung von Isodur gegenüber dem Wasserfloh Daphnia|magna Straus; unpublished study (1108/87). 20 May 1988 [in|German].
BASF AG, 2003, Product Safety, SRC AOP v1.90, data|assessment, unpublished calculation, 9 Dec. 2003
Bridie A.L., Wolff C.J.M. and Winter M. The acute toxicity|of some petrochemicals to goldfish. Water Res.,|13:623-626,1979.
Schultz E. (1960) Arzneimittel-Forsch. 10. 1027. Cited in|BIBRA (1993)
Method: other: screening study with saturated atmosphere
BASF AG, Laboratory of Ecology, unpublished data,|( 98/0419/51/3) , 02.02.1999
Suzuki, J. et al.: Mut. Res. 182, 380 (1987) (abstr.)
Method: other: according to OECD Guide-line 471, preincubation method, addition of S9-mix and norharman
Stephen, H. and T. Stephen. 1963. Solubilities of Inorganic and Organic Compounds-Volume 1. Binary Systems. Part 1: 1-79, 1604-1-43. Pergamon. New York, NY
RBM study report no. 950142 (1996).|Istituto di Recerche Biomediche, Via Ribes 1, 10010|Colleretto Giacosa, Italy||Sponsor (and substance provided by) Industrie Chimche|Caffaro.
Bayer AG (1999). LPT, Hamburg: Acute skin irritation test|(patch test) of calciumformiat technisch in rabbits.|Unpublished study Report No. R 7506, dated August 30, 1999.|Bayer study No. T5067228.
Schering AG. 1988. Determination of the Water Solubility of Di-n-Butyltin Dichloride. Report No. VE 04/88. 02.11.1988.
Method: other (calculated): The vapour pressure was estimated with EPI Suite version 3.20. The modified Grain Method was used.
Sheridan, R.P. (1978): Toxicity of bisulfite to|photosynthesis and respiration. J. Phycol. 14(3), 279-281
BASF AG, Product Safety, Cytogenetic study in vivo with|6-methylhept-5-en-2-one (methylheptenon) in the mouse|micronucleus test after two intraperitoneal administrations,|unpublished report, project no. 26M0874/004151, 00/0874-1,|10 July 2001
European Commission. 2000. European Chemicals Bureau. IUCLID Data Set. 11.02.2000.
BASF AG, Product Safety, Cytogenetic study in vivo with|prenol in the mouse micronucleus test after two|intraperitoneal administrations, unpublished report|(00/274), project no. 26M0274/004055, 14 May 2001
EA Japan (Environmental Agency, Japan) (1999a). Acute|aquatic toxicity of dicyclohexylamine on Oryzias latipes.|MOE (Ministry of the Environment, Japan) unpublished data.
Anderson TA, Beauchamp JJ, Walton BT (1991). Organic chemicals in the environment. Fate of volatile and semivolatile organic chemicals in soils: Abiotic versus biotic losses. J. Environ. Qual. 20, 420-424.
Biodegradation in soil, IUC4#20/Ch.3.1.3
Klerks, P. L., Fraleigh, P. C., and Stevenson, R. C. (1993):|"Controlling zebra mussel (Dreissena polymorpha) veligers|with three oxidizing chemicals: Chlorine, permanganate, and|peroxide + iron." Zebra mussels: Biology, impacts, and|control. T. F. Nalepa and D. W. Schloesser, eds., Lewis|Publishers, Boca Raton, FL, 621-641.
Corazza, M. et al. (1996), Allergic contact dermatitis from|benzyl alcohol, Contact Dermatitis 34, 74-75
incorporation of radiolabelled acetate as a biosynthetic building block of carotenoids and chlorophylls
Yaws CL, Yang HC, Hopper JR and Hansen KC. 1990. Organic|chemicals : water solubility data. Chem Eng, Jul, 115-118
Reported in TOXALL Data Bank from Kamatura M. (1987). Keio|Igaku, 64(2):213-220.
Repeated dose toxicity: inhalation, IUC4#49/Ch.5.4
Cairns, J., Jr. and Scheier, A. (1959) The relationship of|bluegill sunfish body size to tolerance for some common|chemicals. Proc. 13th Ind. Waste Conf., Purdue Univ. Eng.|Bull., 96, 243-252.
Brune, H. et al.: J. Cancer Res. Clin. Oncol. 102, 153-157|(1981);|cited in: IARC Monographs on the Evaluation of Carcinogenic|Risk to Humans, Vol. 51, Lyon, France (1991); pp. 291-390
Hummel Jr NW and Waddington DV: Evaluation of Slow-Release|Nitrogen Sources on Baron Kentucky Bluegrass.Soil Sci. Am.|J. 45, 966-970, 1981
Maurousset, L. et al. (1992): Mechanism of the inhibition of|phloem loading by sodium sulfite: Effect on the pollutant on|respiration, photosynthesis and energy charge in the leaf|tissue. Physiol. Plant. 84(1), 101-105
Bringmann G., Kuehn R. (1982). Findings concerning the|harmful effect of water pollutants on Daphnia magna in an|advanced standardized test procedure. Z. Wasser Abwasser|Forsch.,15(1):1-6.
ELF ATOCHEM: ACIDE AMINO-11 UNDECANOIQUE.Toxicité vis-à-vis |des daphnies.Unpublished report.March 1995.
LaLonde RT, Xie S (1993). Glutathion and N-Acetylcysteine|inactivations of mutagenic 2(5H)-furanones from the|chlorination of humics in water
Gaberg, P. et al.: Mutat. Res. 203, 155-176 (1988), No information
Genetic toxicity in vitro, IUC4#181/Ch.5.5
Hann Jr. RH and Jensen MS (1977). Water quality|characteristics of hazardous materials. Environmental|Engineering Division, Civil Engineering Department, Texas|A&M University.
BASF AG (2006). Department of Product Safety,|SPARC-calculations, 12 Sep 2006, unpublished.
Method: other: calculated with SPARC program
Lewis RJ (1996). Sax's Dangerous Properties of Industrial|Materials. 9th ed., 1-3. New York, Van Nostrand Reinhold, 92
Honma, T., 1982. Significant changes in monoamines in rat|brain induced by exposure to methyl bromide,|Neurobehavioral. Toxicol. Teratol. 4:521-524.
BASF AG, Department of Ecology, unpublished study,|01/88/0667. April 19, 1990.
Chernoff, N. and Kavelock, R.J.: J. Toxicol. Environ. Health|10, 541-550 (1982);
Florin, I. et al.: Toxicology 15, 219-232 (1979)
Method: other: according to Ames, B.N. et al.: Mutation Research 31, 347-364 (1975)
Elf Aquitaine Production, unpublished results. THIODIGLYCOL.|Acute dermal irritation in rabbits. CIT Study No. 12825 TAL.|23 May 1995.
Method: other: OECD Guide-line 404, 1992
Bringmann,G., Kuehn,R., Winter,A., Zeitschrift Wasser|Abwasser Forschung 13(5), 170-173, 1980, No information
ATOFINA, Levallois Application Center, 2001.|UNDECANOIC ACID, 11-AMINO.Toxicité aigüe vis-à-vis des|poissons.Numéro d'étude : 493/00/A.
BASF AG, department of toxicology, Pruefung der akuten|dermalen Toxizitaet an der Ratte (englisch), unpublished|results (88/333), 7-18-88
Wolkowski-Tyl, R., Lawton, A.D., Phelps, M., and Hamm, T.E.:|Jr. Teratology, 27:197-206 (1983a).
BASF AG, (1958a) Report on the study of the sensitizing effect in guinea pigs, Dept. of Toxicology, unpublished study, (VII/310), July 21, 1958
Bringmann, G., Bestimmung der biologischen Schadwirkung|wassergefaehrdender Stoffe aus der Hemmung der|Zellvermehrung der Blaualge Microcystis, Gesund.-Ing. 96|(9): 238-241, 1975 (96)
Wellens (1990): Z. Wasser Abwasser Forsch. 23(3), 85-98
Biodegradation in water: screening tests, IUC4#56/Ch.3.5
TNO Division of Technology for Society (1988): The acute toxicity of Benzoguanamine to Leuciscus idus, Report No. R88/240, June 22, 1988
Method: T40-05:comparable to OECD guideline 408
Singer PC, Lamb JC III, Pfaender FK, Goodman R (1979) Treatability and assessment of coal conversion wastewaters: Phase I. EPA-600/7-79-248. Research Triangle Park, NC: U.S. EPA. PP.178 (cited in BiblioLine(c) 1997-2006, NISC International, Inc. All Rights Reserved.www.nisc.com).
Demnati, R., Fraser, R., Plaa, G. and Malo, J.L. (1995).|Histopathological effects of acute exposure to chlorine gas|on Sprague-Dawley rat lungs. J Env Pathology, Toxicology and|Oncology. 14:15-19.
Kim J., Marshall M.R. and Wei C., 1995, Antibacterial|activity of some essential oil components against five|foodborne pathogens, J. Agricult. Food Chem. 43, 2839-2845
Roederer, G., Testung wassergefaehrdender Stoffe als|Grundlage fuer Wasserqualitaetsstandards.|Fraunhofer-Institut fuer Umweltchemie und Oekotoxikologie,|5984 Schmallenberg, UFOPLAN-Nr. 116 08 071/01, 79 p. (1990)
NTP Annual Plan, Fiscal Year 1984, S. 58
Method: other: modification of the Salmonella/microsome assay
Chemicals Evaluation Research Institute (CERI) - Japan. 2000. CAS No. 1461-25-2 [Tetrabutyltin]. http://www.ceriji.or.jp/ceri_en/index_e.html (accessed June 24, 2000).
Method: other: similar to OECD guideline 305C
Voelkner W. Micronucleus assay in bone marrow cells of the|mouse with FAT 65'023/L. Report CCR Project No. 213333,|Januray 21, 1991. CCR Cytotest Cell Research, Rossdorf,|Germany.
FMC Corporation, unpublished, FMC study no.: ICG/T-78-089|(1987).
Du Pont Haskell Labs (1997) (HL-1997-00203). DMAC:|Developmental toxicity study in Sprague-Dawley rats.|Unpublished data.
Method: other: Tong et al., Mutat. Res. 130, 53-61 (1984)
Kaiser KLE (1983) A Non-linear Function for the|Approximation of Octanol/Water Partition Coefficients of|Aromatic Compounds with Multiple Chlorine Substitution.|Chemosphere 12: 1159 - 1167
E.I. du Pont de Nemours and Company, unpubl. results,|Medical Res. Proj. 9736-001/HLR 92-94, 13 May 1994|(sponsored by NMP Producers Group, USA)
Degussa AG, Sipernat 880 and Extrusil, Safety Data Sheets of|19 Dec. 2002
Standard eye irritation protocols using Draize test
Kuehn, R. and Pattard, M., Water Research 24 (1), 31-38|(1990)
Method: other: Scenedesmus-Zellvermehrungs-Hemmtest, DIN 38412 Teil 9, Bestimmung der Hemmwirkung von Wasserinhaltsstoffen auf Gruenalgen (1988)
BASF AG, Department of Toxicology, unpublished results,|Proj. No. 36I0544/90058, 21 Dec. 1993
Method: other: range-finding study based on OECD guide-line 412
Huels AG (1993). Unpublished report No. AM-93/19. Bestimmung|der Mutagenität von Malonsäurediethylester im|Salmonella/Säuger- Mikrosomen-Mutagenitätstest nach Ames|Mutagenitätstest nach der Richtlinie 84/449/EWG B.14.|Degussa AG-Reg-Nr.: 93-0238-DGM
Danford N (1985) Tests of chromosome aberrations and|aneuploidy in the Chinese hamster fibroblast cell line|CH1-L. Prog Mutat Res 5: 397-411
Method: other: chromosome aberrations and aneuploidy
Method: other: Kurzzeitatmungstest [Short time inhalation test]
BASF AG, Department of Ecology, unpublished study, Oct 10,|1989
BASF Aktiengesellschaft, Abteilung Toxikologie;|unveroeffentlichte Untersuchung (X/26)
Soivio, A., Nikunen, E., Tuurala, H. (1988); Acute response|to sodium hypochlorite in rainbow trout acclimatized to pulp|and paper mill effluents; Aqu. Toxic., 13, 77-88.
De Flora S., Zanacchi P., Camoirano A., Bennicelli C.,|Baldolati GS. (1984), Genotoxic activity and potency of 135|compounds in the Ames reversion test and in a bacterial|DNA-repair test: Mutat. Res. 133, 161-198
Huang Q, Kong LR, Liu YB, Wang LS (1996) Relationships|between molecular structure and chromosomal aberrations in|in vitro human lymphocytes induced by substituted|nitrobenzenes. Bull Environ Contam Toxicol 57: 349-353
Method: other: cultures of whole blood were incubated for 48 h, then add. of TS in 10 ul DMSO for 24 h; 2h before termination colchicine was added, staining with giemsa, 100 cells/culture were recorded, 5 duplicate cultures
Wells Laboratories, Inc. 1975. Report on Inhalation LC50 in Rats Using Dibutyltin Dichloride. Laboratory No. G-1226. 05.12.1975.
Method: other: Cell multiplication-inhibition test
Method: other: 15 rats/dose group, 8 doses dissolved in polyethylenglycol 400, given by gavage, observation time: 14 d
Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA102, TA104
Method: other: tested with standard EEC or OECD methods or comparable procedures
Fornace Jr. A.J. et al.: Carconogenesis 3, 1373-1377 (1982), No information
Genetic toxicity in vitro, IUC4#192/Ch.5.5
Yalkowsky, S.H. and R.M. Dannenfelser. 1992. AQUASOL Database of Aqueous Solubility. 5th ed. University of Arizona. College of Pharmacy. Tuscon, AZ
Method: Other (Calculated):structure estimation method
1-(2-butoxy-1-methylethoxy)propan-2-ol (IUC4 DSN 53)
Method: other: specific investigation of morphological and morphometric changes in the respiratory tract
Kuhlmann, A., Moeglichkeiten des mikrobiellen Abbaus von|Chlornitrobenzolen, Wasser, Abwasser 140, 470 - 471 (1999)
Anderson, B.G. (1948) The apparent thresholds of toxicity to|Daphnia magna for chlorides of various metals when added to|lake Erie water. Trans. Am. Fish. Soc., 78, 96-113.
BASF AG, Product Safety, data assessment, SRC KOWWIN v1.66,|25 Oct. 2002
BioReliance (2002) In Vitro Mammalian Chromosome Aberration|Test, Study No. AA49NY.331.BLT, Project No. 01-021, March 4,|2002.
KOWWIN v1.51, SRC-Log KOW for Microsoft Windows, Copyright|W. Melyan, 1993 - 1996, No information
Recio, L., et al.: Cancer Research, 52, 6113-6116, (1992), No information
Genetic toxicity in vivo, IUC4#89/Ch.5.6
Lide, D.R. Editor (2007-2008) CRC Handbook of Chemistry and|Physics, 88th Edition, CRC Press.
Burns LA, Bradley SG, White KL, McCay JA, Fuchs BA, Stern M,|Brown RD, Musgrove DL, Holsapple MP, Luster MI, Munson, AE|(1994) Immunotoxicity of mono-nitrotoluenes in female|B6C3F1-mice: I. para-nitrotoluene. Drug Chem Toxicol 17:|317-358
Matsui, S.; Y. Okawa & R. Ota, Experience of 16 yearsoperation and maintenance of the Fukashiba industrial|wastewater treatment plant of the Kashima petrochemical|complex - II. Biodegradability of 37 organic substances and|28 process wastewaters, Water Sci. Technol. 20,|201-210 (1988) (17)
BASF AG, Department of Experimental Toxicology and Ecology. Additional histopathological examination of pups from an OECD 421 screening study. Unpublished report to project No. 90R0019/01075 dated 11 August 2003.
Foureman P, Mason JM, Valencia R and Zimmering S (1994).|Chemical mutagenesis testing in Drosophila. X. results of 70|coded chemicals tested for the National Toxicology Program.|Environ. Molec. Mutagen.23, 208-227.
Dogimont C. (1988), "Etude cinetique des reactions du|chlorure d'allyle et des di-, tri- et tetra-chloromethanes|avec de l'eau en milieu neutre ou basique", Solvay Internal|report no. LC 88-2047.
Hecht SS, El-Bayoumy K, Tulley L, and LaVoie E (1979)|Structure-Mutagenicity Relationships of N-Oxidized Derivates|of aniline, o-Toluidine, 2'-Methyl-4-aminobiphenyl, and|3,2'-Dimethyl-4-aminobiphenyl. J Med Chem 22: 981-987
Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538, G 46, C 3076, D 3052; E coli WP2, WP2uvrA-
Liu, J.-l. and Lang, P.-z., Effect of monotoxicity and|mixtoxicity of nitroaromatics to the green algae,|Scenedesmus obliquus, Journal of Environmental Sciences 12|(3), 367-368 (2000)
Method: other: OECD 201 (Algae, Growth inhibition test, 1981)
Method: other: 5 rats/sex/group, whole body exposure, complete necropsies on all rats, histopatholologic evaluation of all rats in the controls and the highest exposure group
Method: other (calculated): Calculation by AOP Win v1.86 (Syracuse Research Corporation)
J.R. Geigy S.A. (1970) Documenta, Geigy, 7th ed. Basle; as|cited in FAO/WHO World Health Org. Techn. Rep. Ser. No. 539,|1974. Cited in United States Environmental Protection Agency|(1991)
Jarisch, R. and Sandor, I. (1978), Epicutanstandardtestung:|Ergebnisse aus fünf Jahren und ihre Auswirkungen auf|zukünftige Untersuchungen, Z. Hautkr. 53, 462-470
BASF AG (1970). Department of Toxicology. Ergebnis der|Gewerbetoxikologischen Vorprüfung (XX/174), unpublished|data, 16 Sep 1970.
Hayman and R. Derwent Environ. Sci. Technol. 1997, 31,|327-336.
Smyth HF and Carpenter CP, Weil CS (1951) Range-Finding|Toxicity Data: List IV, Archives of Industrial Hygiene and|Occupational Medicine 4, 119-122
Degussa AG, unpublished report, 1990, Acute toxicity in the guppy, Degussa Report No. 90-0043-DGO
Burek, J.D., Potts, W.J., Gushow, T.S., Keyes, D.G. and|McKenna, M.J.: Toxicology Research Laboratory, Health &|Environ. Sciences, The Dow Chemical Company, Midland,|Michigan. (Final Report February 1981).
Method: other: Draize Test, see freetext ME
BASF AG, Department of Toxicology, Study of|3-methylbuten-2-ol-1 in the Liquid Suspension Assay,|unpublished report (88/360), project no. 41M0360/884497, 19|Sept. 1991
Daubert, T.E. et al. (1987) AICHE Symp Ser 83: 128-56
Froning J.F., Hennion G.F.: Am Soc. 62, 654 (1940)
Senff, Von H. et al: Allergisches Kontaktekzem auf|Dicyandiamide, Dermatosen, 36 Heft 3(1988)
BASF AG (1988). Department of Ecology. Short-term|Respiration Inhibition Test, study No. 01.0048/88, 13 April|1988, unpublished.
Method: other: following OECD Guide-line 209
Lonza AG, unpublished report, 1990, Acute eye irritation in the rabbit, Lonza Report No. 1350
Murota, T. and Murakami, A.: Mutat. Res. 38, 343-344 (1976);|abstract no. 14
Van Leeuven C.J., Van der Zandt P.T.J., Aldenberg T.,|Verhaar H.J.M., and Hermens J.L.M., (1992). Application of|QSARs, extrpolation and equilibrium partitioning in aquatic|assessment: I. narcotic industrial pollutants. Environ.|Toxicol. Chem. 11,267-282.
Dorado G, Pueyo C (1988) L-Arabinose Resistance Test with|Salmonella typhimurium as a Primary Tool for Carcinogen|Screening. Cancer Res 48: 907-912
Method: other: L-arabinose-resistence test with S typhimurium
BASF AG, Safety data sheet 2-METHOXY-2.3-DIHYDRO-4H-PYRAN,|07.11.2001
BASF AG, Department of Toxicology, unpublished results,|Proj. No. 40I0544/90067, 26 Oct. 1993
FMC Corp. data cited in Chem. Reg. Reporter 11-13-87,|1244-1322 (1987)
Matthews, E.J. et al., Prog. Mutat. Res. 5, 639-650 (1985)
Yoon JS, Mason JM, Valencia R, Woodruff RC and Zimmering S|(1985) Chemical mutagenesis testing in Drosophila. IV. |Results of 45 coded compounds tested for the NTP. Environ |Mutagen, 7, 349-367.
Method: other: equivalent to OECD Guide-line 477
Werner, D.I. (2003), "Epsilon-Caprolactone - Determination|of the inhibitory effect on the cell multiplication of|unicellular green algae", BASF Experimental Toxicology and|Ecology Project No. 03/0034/60/1
Suzuki, J. et al.: Mutation Research 120, 105-110 (1983)
Method: other: according to OECD Guide-line 471, preincubation method, without S9-mix, and with S9-mix and 200 ug/plate Norharman
American Industrial Hygiene Association Journal (1969) (AIHAJ),|475 Wolf Ledges Pkwy., Akron, OH 44311. Vol. 30:470
BASF AG, 2003, Department of Product Safety, Labortaory of|Ecology, Growth inhibition test according to|Brinkmann-Kuehn: "78% choline chloride dissolved in water",|unpublished data, reprint of report No. 9/0111/88/w3 (18 May|1988), 16 Sept 2003
Method: other: DIN 38412 Teil 8, draft; inhibition of cell multiplication
Amacher DE, Turner GN (1985) Tests for gene mutational|activity in the L5178Y/TK assay system. Prog. Mut Res 5:|487-496
Method: other: according Clive et al., 1972, 16, 77-87 and Mutation Res. 31, 17-29 (1975)
Hughes JB, Wang CY, and Zhang C (1999). Anaerobic|biotransformation of 2,4-dinitrotoluene and|2,6-dinitritoluene by Clostridium acetobutylicum: A pathway|through dihydroxylamino intermediates. Environ. Sci.|Technol. 33, 1065-1070.
Method: other: 14C batch degradation experiments
Barden, A.E., Vandongen, R., Beilin, L.J., Margetts, B.,|Rogers, P. (1986). Potassium supplementation does not lower|blood pressure in normotensive women. Journ. Hypertension.|4:339-343.
Kirk-Othmer Encyclopedia of Chemical Technology, 3rd|edition, Vol. 2, p. 88, 1978.
Ministry of Health & Welfare, Japan (1996c): Toxicity|Testing Reports of Environmental Chemicals, vol.4 p111-114,|"In Vitro Chromosomal Aberration Test of|2-Amino-5-methylbenzenesulfonic acid on Cultured Chinese|Hamster Cells".
Lemke AE, Durhan E and Felhaber T / U.S. EPA Environ. Res.|Lab., Duluth, Mn (1983). Evaluation of a fathead minnow|Pimephales promelas embryo-larval test guideline using|acenaphthene and isophorone, U.S. EPA Report No.|600/3-83-062.
BASF AG, department of ecology, personal communication,|06.06.2000
Spanggord JR, Mabey RW, Mill T, Chou TW, Smith JH and Lee S|(1981). Environmental fate studies on certain munition|wastewater constituents. Phase III, Part II-Laboratory|studies. NTIS. US Army medical research and development|command. Contract no. DAMD 17-78-C-8081. AD A133987 pp.|4171.
Method: other: Degradation in shake flask
Industrial Bio-test Laboratories, Inc., Report to Ciba-Geigy|corporation: Human repeated patch test with Irganox 1076, |IBT No. 636-06407, 10.4.1975.
Method: other: acute oral by gavage, Internal Union Cabide method (gavage). Thompson's method of calculating median-effective dose.
Environmental Agency, Japan:(1998) unpublished report on|Daphnia magna Reproduction Test (No.91908)
Method: other (calculated): with SRC-AOPWIN v. 1.90 (2000)
Fukushima, S. et al. (1987): Cancer Res. 47, 2113 - 2116
Method: other: Esophagus and Forestomach Carcinogenesis Promotion Assay
MacPhee C and Ruelle R (1969). Lethal Effects of 1888|chemicals upon four species of fish from western North|America. University of Idaho Forest, Wildl. Range Exp.|Station Bull. No. 3, Moscow, ID; 112 p. (also cited in|Aquire)
Wellens H (1990) Zur biologischen Abbaubarkeit mono- und disubstituierter Benzolderivate. Zeitschrift fur Wasser und Abwasserforschung 23:85-98.
Waalkens-Berendsen, D.H. 2004. Tetrabutylstannane (CAS # 1461-25-2): Combined oral repeated dose toxicity study with the reproduction/developmental toxicity screening test in rats. TNO Report V4904. 29 January 2004.
Hooftman, R.N. and J.M. de Wolf. 2003. Dibutyldichlorostannane (CAS# 683-18-1): Static acute toxicity test with the crustacean species Daphnia magna. TNO Report No. V2495/02. August 2003.
Analytical Bio-Chemistry Laboratories. 1990. Acute Toxicity of Dibutyltin Dichloride to Daphnia magna. ABC Final Report #38309. Sponsored by the Consortium of Tributyltin Manufacturers [M&T Chemicals, Inc., Woodbridge, NJ and Sherex Chemicals Co., Inc., Dublin, OH]. June 6, 1990.
Method: other: USEPA Method for Acute Toxicity Tests with Fish, Macroinvertebrates, and Amphibians (EPA-660/3-75-009; 1975) and Standard Methods for the Examination of Water and Wastewater (APHA, 15th ed.)
Bringmann G and Kuehn R (1977). Befunde der Schadwirkung|wassergefaehrdender Stoffe gegen Daphnia magna. Z. Wasser-|Abwasser-Forsch. 10 (5), 161-166.
Method: other: Similar to OECD TG 403, Inhalation Hazard Test. According to Smyth et al. (1962) Am. Ind. Hyg. Ass. J. 23: 95-107
Ishidate, M., Sofuni, T., Yoshikawa, K. et al. (1984):|Primary mutagenicity screening of food additives currently|used in Japan. Fd. Chem. Toxic., 22(8), 623-636.
Standard eye irritation protocol using Draize test
Worden, A.N., J.S. Leahy, S.A.D. Mowatt, and A. Tame. 1957. Rept. Nutritional Res. Unit. Huntington Res. Centre. IN Toxicological Data on Organotin Compounds. Smith, P.J. International Tin Research Institute. Publication 538.
Kubo A. and I. Kubo, Antimicrobial agents from Tanacetum|balsamita, J. Natur. Prod. 58(10), 1565-1569, 1995
Method: other: antimicrobial activity testing
Monsanto Material Safety Data Sheet for ONCB and PNCB,|St. Louis, Mo., Monsanto Company (1985): cited in|Nair, R.S. et al.: Fundamental and Applied Toxicology|7, 609-614 (1986)
Method: other: 2 or 3 rats/dose, single oral dose as 10 % warm solution, observation time: 7 d
Applegate VC, Howell JH, Hall AE and Smith MA (1957). Toxicity of 4,346 Chemicals to Larval Lempreys and Fishes. Spec.Sci.Rep.Fish.No.207, Fish Wildl.Serv., U.S.D.I., Washington D.C.:157.
Degussa-Huls AG #: 76-0043-DKT|Six silane samples: Acute toxicity investigations.
Microbiological Associates (1984a). Activity of isophorone|in the micronucleus cytogenetic assay in mice, Report No.|T2408.121001.
Method: other: Micronucleus Cytogenetic Assay
OLIN CORPORATION Stamford|OLIN S.A. Roissy CDG
Ehhalt,D.H., Sci. Total Environment 143, 1-15, 1994, No information
Wangenheim, J. and Bolcsfoldi G.: Environ. Mutagen. 8, 90|(1986); abstract no. 240, No information
Method: other: Daphnien-Schwimmunfaehigkeits-Test, UBA-Verfahrensvorschlag Mai 1984, Bestimmung der Schwimmunfaehigkeit beim Wasserfloh Daphnia magna, EC0, EC50, EC100 24h, statisches System
Litton Bionetics Inc. Mutagenicity Evaluation of N-Octylzinntrichlorid in the Ames Salmonella/Microsome Plate Test. Final Report. 11.1978. (Revised 5.1979)
National Center for Biotechnology Information (2004) National Library of Medicine. National Institutes of Health. PubChem Comound Summary on Resorcinol (CID 5054).
Collins, T.F.X. et al.: Fd. Chem. Toxic. 25, 647-662 (1987)
Nishikawa Y, Okumura T (1995) Determination of nitrobenzenes|in river water, sediment and fish samples by gas|chromatography - mass spectrometry. Analytica Chimica Acta|312: 45 - 54
Philip H. Howard, William M. Meylan, Handbook of Physical|Properties of Organic Chemicals.
Baer, R.L. et al. (1955), STUDIES ON ALLERGIC SENSITIZATION|TO CERTAIN TOPICAL THERAPEUTIC AGENTS, Arch. Dermatol. 71,|19-23
Salmonella typhimurium TA98, TA100, TA1535, TA1537, Escherichia coli WP2, WP2uvrA
Dorange J-L, Dupuy P (1972) Mise en évidence d'une action|mutagène du sulfite de sodium sur la levure. CR Acad Sci|Paris, Série D, 274: 2798-2799 (In French)
Schuyten, H., J. Weaver, and J. Reid. (1947) J. Am. Chem.|Soc. 69:2110.
Nieminen, M. et al.: Comp. Biochem. Physiol. 75C, 265-269|(1983);|cited in: IPCS Environ. Health Crit. 89, (1989), No information
Short-term toxicity to fish, IUC4#74/Ch.4.1
Sarasin G (1982) FAT 65'023/L: Acute oral LD50 in the rat.|CIBA-GEIGY Ltd. CH-4002 Basel (Switzerland), Report No.|820600
Koopman, T.S.M. and Pot, T.E. (1986) Primary irritation|study of calcium chloride hexahydrate to the eye of the male|rabbit. Duphar Report No. 56645/44/86.
Method: other: U.S. EPA 40 CFR 797 Guideline 797.1300
Dow Corning Corporation (1983) Genetic Evaluation of Dow|Corning Z-6079 Silane in Bacterial Reverse Mutation Assays. |HES Study Number 1035-4. Report Number: 1983-I0005-1080.
Method: other: OECD Guidelines 419 and 420
Hansen JM, Contreras KM, and Harris C (2005). Methanol,|formaldehyde, and sodium formate exposure in rat and mouse|conceptuses: a potential role of the visceral yolk sac in|embryotoxicity. Birth Defects Research (Part A); Clinical|and Molecular Teratology 73, 72-82.
Bayer AG (1976). Internal Study: Toxicity of o-toluidine to|Leuciscus idus. (1976-06-03).
Method: other: Bestimmung der akuten Wirkung von Stoffen auf Fische. Arbeitskreis "Fischtest" im Hauptausschuss "Detergentien" (1973.10.15)
Acute toxicity: inhalation, IUC4#36/Ch.5.1.2
Dupont de Nemours (1982) Eye irritation test of|1-Chloro-4-nitrobenzene. Rep.-No. 57-82, 20. Jan. 1982:|EPA-OTS0557116
Method: other: 10 mg TS was placed into the right conjunctival sac of each of 2 rabbits: after 20 sec. the treated eye of 1/2 rabbits was washed with tap water for 1 min., the other was not washed; observation: at 1 and 4 hours, at 1, 2, 3 day
Method: other: UBA-Verfahrensvorschlag "Letale Wirkung beim Zebrabaerbling Brachydanio rerio" ( LC 0, LC 50, LC 100; 48-96 Stunden) (Mai 1984)
Kwok and Atkinson (1994) as reported in AOPWIN version 1.90.|Atmospheric Oxidation. EPIWIN (Estimation Program Interface|for Windows) version 3.10. U.S. Environmental Protection|Agency (2001).
Short-term toxicity to aquatic invertebrates.004
S. typhimurium TA98, TA100, TA1535, TA97
Marhold. (1972) Sbornik Vysledku Toxicologickeho Vysentreni|Latek a Pripavku 1971: 52
Zijlstra, J.A.: Mutat. Res. 210, 255-261 (1989), No information
Flaningam, O.L. and Smith, A.L. (1994). Dow Corning|Corporation, Report No. 1994-I0000-39053.
BUA-Report: 3-Methyl-2-butenal, N. 194 (Aug. 1996), S.|Hirzel, 1997
Hoberman A., 1989, Reproductive and developmental toxicity screening test of B10 administered orally via gavage to Crl:CD(SD)BR female rats, Lorillard Inc.
DuPont Chem (1972) Acute oral test of para-nitrotoluenen in|rats. February 16, 1972: NTIS/OTS 0572887
Dearden JC, Cronin MTD (1996) Quantitative|Structure-Biodegradability Studies: An Investigation of the|MITI Aromatic Compound Data-Base. NATO ASI Series Ser. 2.|Environment (23): 93 - 104
BASF AG (1987). Department of Ecology, study No. 01.456|(unpublished).
Verschuuren, H.G. (1994) Unpublished report of Dow Europe.
Besson MA (1897). Action de l'eau sur le trichlorure de|phosphore. Compt. Rend. 125, 771-772.
Kramer, Truemper, Berger (1986): Biochem. Physicol. Pflanzen||181, 411-420
Method: other: Standardised growth test. BOHM et al., (1972): Selection method of biochemical active substances. DD Nr 94234/C 12K 1/00
Bayer AG (1975). Internal report: Biodegradability of|N,N-Dicyclohexylamine. Report rewritten 2001-03-02.
Method: other: BBA Nr. VI, 1-1 (1990) "Dehydrogenase activity of soil microflora"
Toxicity to soil microorganisms, IUC4#12/Ch.4.4
BASF AG, 2004, Product Safety, SRC BCFWIN v2.14, data|assessment, 26 Jan 2004
Method: other: calculated with BCF v2.14 using measured logKow
De Meester C, Mercier M and Poncelet F (1981). Mutagenic|activity of butadiene, hexachlorobutadiene and isoprene. In:|Industrial and Environmental Xenobiotics. Edited by I Gut, M|Cirkt and GL Plaa. Springer Verlag, Berlin, pp. 195-203.
Terhaar CJ, Ewell WS, Dziuba SP, and Fassett DW (1972).|Toxicity of photographic processing chemicals to fish.|Photographic Science and Engineering 16(5), 370-377.
L5178Y TK+/- mouse lymphoma cells, in situ variant
Dahl, C. (2000): Schwefelverbindungen als|Elektronendonatoren für die Photosynthese anoxygener|phototropher Bakterien. Biospektrum 4, 263-266
Bayer AG, Safety data sheet, cited in BAYER base data set
BASF AG, 2003, Department of Product Safety, unpublished|calculation, SRC AOP v1.90, 25 June 2003
Hoechst AG (1983): Unpublished study: BONS TTR Prüfung der|akuten oralen Toxizität an der männlichen und weiblichen|Wistar-Ratte (in German) (Ber.-Nr. 83.0661), 2 Dec 1983
Van Duuren BL, Goldschmidt BM, Seidman I (1975). Carcinogenic activity of di- and trifunctional alpha-chloro ethers and of 1,4-dichlorobutene-2 in ICR/HA Swiss mice. Cancer Res. 35, 2553-2557.
Häner A (2002): Ultimate Biodegradability, evaluation of the|anaerobic biodegradability in an aqueous medium. BMG report|no. 342/b-02, August 21, 2002; on behalf of F. Hoffmann-La|Roche Ltd.
Reuzel, P.G.J., Dreef-Van der Meulen, H.C., Hollanders,|V.M.H., Kuper, C.F., Feron, V.J. Van der Heijden, C.A. 1991.|Chronic inhalation toxicity and carcinogenicity study of|methyl bromide in Wistar rats. Food Chem. Toxicol., 29:|31-39
Method: other: 10 rats/sex/group, reproductive system evaluation: vaginal cytology, sperm morphology, necropsy body and reproductive tissue weights, spermatozoal data, spermatogenesis, estrous cycle length, percent of cycle spent in various
Neeper-Bradley T and Ballantyne B (1996). Absence of|dominant lethal effects in male CD® rats exposed to|5-ethylidene-2-norbornene vapor. Toxic Substance Mechanisms|15, 389-404.
BASF Corp. Internal Report dated 9/19/91
Method: other: DIN Test Method 38412 Part 9
Huels AG (1997). Bestimmung der biologischen Abbaubarkeit|von Isophoron im Coupled Units-Test, Report No. CU-0433|(unpublished).
Biodegradation in water and sediment: simulation tests, IUC4#20/Ch.3.5
Method: other: acute toxicity of benzotrichloride after single oral treatment of male Wistar rats
Yamaguchi, T., Mutagenicity of trioses and methyl glyoxal on|Salmonella typhimurium, Agric. Biol. Chem., 46 (3), 849-851,|1982 (84).
Huntingdon Life Sciences Ltd. (2003a). Assessment of|Biodegradability Using the Closed Bottle Method. Project ID|CSS/036. Huntingdon Life Sciences Ltd., Cambridgeshire,|England.
BASF AG, Department of Ecology, Bestimmung der akuten|Wirkung von 3-Methyl-2-al-1 gegenüber dem Wasserfloh Daphnia|magna Straus, unpublished study, Rep.-No.|1/1059/2/87-1059/87, 21 Jan. 1988
Repeated dose toxicity: oral, IUC4#27/Ch.5.4
Hardin BD, Goad PT, Burg JR. 1984. Developmental toxicity of four glycol ethers applied cutaneously to rats. Environ Health Perspect 57:69-74.
BASF AG, TAIPV-VT II L 540, unveröffentlichte Untersuchung,|22.04.1965
Method: other: comparable to OECD 203 (Fish: Acute Toxicity Test, 1992)
Bayer AG (1973) Internal study: Test on Ready|Biodegradability According to Closed Bottle Test (Internal|report written 2000-07-04)
Method: other: Test corresponds to a Closed Bottle Test (OECD 301 D)
BASF AG, Department of Ecology, unpublished study, 905,|J.-No. 23566, 03.04.1985
Berufsgenossenschaft der chemischen Industrie,|Triethylenediamine: Micronucleus Test in Bone Marrow Cells|of the Mouse, APCI RRRS EXT-03/012, 25 Mar 1987
Method: other: Manometric determination, cf. Test conditions
Method: T09-02:1 rabbit/dose, 6 doses, single application of undiluted, warmed substance, exposure time. 24 hrs, postexposure observation time: 14 d ( no further information)
Bayer AG 2003, Calculation of |- Henry's Law Constant with SRC-HENRYWIN v. 3.10, 2000|- Indirect Photodegradation with SRC-AOPWIN v. 1.89, 2000|- Soil Adsorption Coefficient with SRC-PCKOCWIN v. 1.66,|2000|- Mackay-Distribution Level I according to Mackay, D., 1991
Method: other: (measured) see test conditions
Adsorption / desorption, IUC4#80/Ch.3.3.1
Prinsen, M.K. 2003. Tetraoctylstannane [CAS # 3590-84-9]: Acute oral toxicity study with rats. TNO report V4410/18. TNO Nutrition and Food Research. Study conducted for the Organotin Environmental Programme (ORTEP) Association Stabilizer Task Force. 9p.
Hoechst AG (1989): Unpublished study: chromosome aberrations|in vitro in V79 chinese Hamster cells. Report no. 89.0025,|18 Jan 1989
Allyl Alcohol Consortium (2005e). WSKOW v1.41 Calculations,|Unpublished Data
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DuPont (1980). Chinese hamster ovary cell assay for mutagenicity. Haskell Laboratory, Report No. 902-80 from September 24, 1980.
Zepp R and Cline D (1977). Rates of direct photolysis in the|aqueous environment, Environ. Sci. Technol., Vol. 11, pp.|359-366.
BASF AG, department of toxicology, Bericht ueber die|Pruefung der akuten Toxizitaet an der Goldorfe (Leuciscus|idus L., Goldvariante); englische Fassung, unpublished|results (88/208), 1-25-89
Method: other: according to DIN 38 412, Bestimmung der Wirkung von Wasserinhaltsstoffen auf Fische - Fischtest (L15)
Carreon RE and Wall JM (1984) "Propylene glycol monomethyl ether: skin sensitization potential in the guinea pig",|unpublished report of the Dow Chemical Company.
BioReliance (2008) In Vitro Mammalian Chromosome Aberration|Test. Study No. AC04RZ.331.BTL
BASF AG (1988). Department of Ecology. Modified OECD|Screening Test, study No. 52/048/88, 28 Sep 1988,|unpublished.
tetrahydromethylphthalic anhydride (IUC4 DSN 20)
Nishino SF, Paoli GC, Spain JC (2000). Aerobic degradation|of dinitrotoluenes and pathway for bacterial degradation of|2,6-dinitrotoluene. Appl. Environ. Microbiol. 66, 2139-2147.
Monsanto Chemical Co. (not dated, b) Dermatitic effects of|Santoflex IP and Santoflex 13. Draft, unpublished report
Pekkala CM and Koopman B (1987) Water Air Soil Pollut, 36,|155-162
Toxicity to aquatic algae and cyanobacteria, IUC4#12/Ch.4.3
BASF AG, 1972, Department of Technical Development and|Technology, Dampfdruckmessungen, unpublished study, report|No. 172.524.1, 29 Nov. 1972
Daston, G.P. et al.: Fund. Appl. Toxicol. 17 (4), 696-722|(1991);|cited in: RIFM database, location no. 15829
Njagi GDE, Gopalan HNB (1980) Mutagenicity testing of some|selected food preservatives, herbicides and insecticides: II|Ames test. Bangladesh J Bot 9: 141-146
Turck PA. Prenatal developmental toxicity study of C.I.|fluorescent brightener 220 administered via oral gavage to|New Zealand white rabbits. Report Laboratory Study No.|795-004, January 27, 2000. MPI Research, Mattawan, USA.
Weisfeld, L.B. 1975. Kunstoffe. 65:298.
Escherichia coli WP2 uvrA + WP2 uvrA /pKM101
Schering AG. 1969. Systemic Test of Rat Tolerance to a Single Oral Dose (LD50) - ZK No. 24911. Prot.-Nr. 1173. Bergkamen, Germany. 30.07.1969.